CN103055260B - Traditional Chinese medicine composition for treating ulcerative colitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating ulcerative colitis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating ulcerative colitis, and a preparation method thereof. The composition of the traditional Chinese medicine for treating ulcerative colitis is prepared by mixing the components in parts by weight as follows: 10-30 parts of chrysanthemum, 15-25 parts of pericarpium citri reticulatae, 10-30 parts of radix curcumae, 10-30 parts of hawthorn, 5-15 parts of liquorice, 15-25 parts of fructus amomi, 20-40 parts of endoconcha sepiae, 5-10 parts of coptis chinensis, 2-8 parts of gizzard pepsin, 15-25 parts of mangnolia officinalis, 30-50 parts of Chinese-date flesh, 10-20 parts of bletilla striata, 20-30 parts of rhizoma corydalis and 25-35 parts of propolis. The composition of the traditional Chinese medicine has the benefits that the composition is reasonable; a synergistic effect of every component is achieved; the composition of the traditional Chinese medicine has the functions of clearing away heat, drying dampness, tonifying spleen, nourishing stomach and the like, is good in curative effect, can take effect quickly and achieve the effect of treating both symptoms and root causes, and can be prepared easily; the components can be mixed more uniformly step by step; the composition of the pure traditional Chinese medicine is free from pollution, drug residues and drug resistance, low in cost, wide in material drawing range, high in availability and remarkable in curative effect; and superfine grinding is achieved.
Description
Technical field
The present invention relates to Chinese medicine composition, particularly a kind of Chinese medicine composition for the treatment of ulcerative colitis.
Background technology
The symptom of ulcerative colitis mainly contains: diarrhoea, hemafecia, stomachache and intestinal show outward.When the inflammatory reaction of intestinal wall internal layer is more and more serious, and when forming ulcer, it just loses the function absorbing moisture from food debris.Correspondingly, feces will be caused more and more looser---in other words, suffer from diarrhoea exactly.Impaired intestinal mucosa also can cause Mucous Stool.Meanwhile, the ulcer of mucous layer also can cause bleeding, and therefore produces hemafecia.In fact, what continue loses blood and can cause anemia.Most patients of ulcerative colitis may have fecal urgency and abdominal colic, and this pain may based on the left side, because colon hypomere is positioned at the left side.Diarrhoea and stomachache may cause the decline of poor appetite and body weight, and these symptoms also can cause tired, and this is equally also one of side effect of anemia.The child patient of ulcerative colitis may affect growth promoter.The patient of ulcerative colitis 8 ~ 10 years medical histories is had to obtain colon cancer risk higher.
At present, ulcerative colitis does not have effect method, and the most frequently used drug main will be divided into following a few class:
Salicylates: what this kind of medicine was the most cheap is sulfasalazine, oral rear need the help of human body intestinal bacterium just can be decomposed into 5-aminosalicylic acid play therapeutical effect, but the another kind of pharmaceutical compositions sulfapyridine decomposed then may have infringement to liver, therefore the patient taking such medicine does not finally take antibiotic simultaneously, and monthly makes regular check on liver function (transaminase).
Glucocorticoid: this kind of medicine mainly contains oral formulations prednisone, patient with severe symptoms also can short-period used intravenous formulations.Because its side effect is more, be not recommended for as long-term therapy treatment or maintaining treatment.
Immunomodulator: this kind of medicine comprises azathioprine, Ismipur (6-MP), ciclosporin.The continuation development that medicine controls inflammation by suppressing the immune system of body.Immunomodulator is applicable to those para-aminosalicylic acid class medicines and glucocorticoid and uses the invalid or effective patient of part, is also one of best medicine of current maintaining treatment.It also can be used for alleviating or eliminate the dependence of patient to glucocorticoid.When patient is reactionless to other drug, it may work to the alleviation maintaining disease.But such medicine starts onset about generally taking March, some patients easily occurs that leukocyte reduces.
If this disease is cured not in time, not only can affect the routine work study of patient, and great misery can be brought to sufferers themselves, cause white elephant to family, society.The medicine of some analgesic effect, can only take stopgap measures and can not effect a permanent cure, pain relief after medication, but can recur again after drug withdrawal, and medication repeatedly, easily forms Drug resistance, obstinate.
Summary of the invention
In order to make up the deficiencies in the prior art, the invention provides a kind of Chinese medicine composition of effective treatment ulcerative colitis.
Concrete scheme is as follows: 1, a kind of Chinese medicine composition for the treatment of ulcerative colitis, by following component by weight mixed preparing form: Flos Chrysanthemi 10-30 part, Pericarpium Citri Reticulatae 15-25 part, Radix Curcumae 10-30 part, Fructus Crataegi 10-30 part, Radix Glycyrrhizae 5-15 part, Fructus Amomi 15-25 part, extra large Piao sheath 20-40 part, Rhizoma Coptidis 5-15 part, Endothelium Corneum Gigeriae Galli 2-8 part, Cortex Magnoliae Officinalis 15-25 part, Fructus Jujubae 30-50 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 part, Rhizoma Corydalis 20-30 part, propolis 25-35 part.
On the basis of such scheme, the present composition preferably by following component by weight mixed preparing form: Flos Chrysanthemi 20 parts, Pericarpium Citri Reticulatae 20 parts, Radix Curcumae 20 parts, Fructus Crataegi 20 parts, 10 parts, Radix Glycyrrhizae, Fructus Amomi 20 parts, 30 parts, extra large Piao sheath, Rhizoma Coptidis 10 parts, Endothelium Corneum Gigeriae Galli 5 parts, Cortex Magnoliae Officinalis 20 parts, Fructus Jujubae 40 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, Rhizoma Corydalis 25 parts, propolis 30 parts.
Raw material as follows with performance evaluation that the present invention adopts:
Flos Chrysanthemi: heat-clearing and toxic substances removing, dispelling wind and heat pathogens, summer-heat removing, pathogenic fire reducing sore-throat relieving, promoting the production of body fluid to quench thirst, removes anemopyretic cold, warm blood fulminant dysentery, the swollen furuncle of pain, the effects such as epidemic febrile disease heating;
Pericarpium Citri Reticulatae: bitter, pungent, warm, returns lung, spleen channel, has the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly poor appetite, stomachache, tripe be swollen, have loose bowels, productive cough due to phlegm-damp etc.
Radix Curcumae: bitter, acrid, cold, returns lung, liver, heart channel, has the function of promoting QI circulation for relieving depression, removing heat from blood and promoting blood circulation, promoting the function of the gallbladder to alleviate jaundice; Promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, pure and fresh removing heat from blood, function of gallbladder promoting, cures mainly distension and fullness of the chest and abdomen, intestinal Huang has loose bowels calentura coma, demented, spits blood, stranguria with blood, sand Stranguria, jaundice, calentura coma, jaundice due to damp-heat etc.
Fructus Crataegi: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.Address eating accumulation, abdominal distention, dysentery, dysmenorrhea due to blood stasis, amenorrhea, puerperal abdonimal pain, lochiorrhea, hernia or painful and swollen testis, hyperlipidemia;
Radix Glycyrrhizae: property is put down, sweet in the mouth.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, nourishing the lung to arrest cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen and extremity contraction, carbuncle sore tumefacting virus, can the toxicity of cushion, strong;
Fructus Amomi: nature and flavor function, Xin Wen, promoting the circulation of QI to alleviate the stagnation in middle-JIAO, preventing or arresting vomiting is antiabortive, cures mainly stomach abdominal distention and pain;
Sea Piao sheath: another name Os Sepiae, ink fountain fishbone, it has astringing to arrest bleeding, relieving leukorrhea by astringents, effect of antacid sore, has blood in stool for acid regurgitation of having a stomachache, haematemesis, metrorrhagia, seminal emission, spermatorrhea, red blood leukorrhagia;
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication, damp and hot for the intestines and stomach, sore and toxic, quench one's thirst, there is antimicrobial, anti-bacteria, virus, fungus and protozoacide, antidiarrheal, stomach invigorating, improve gastric juice, pancreatic juice, the secretion of bile, promote gastrointestinal motility, strengthen acetylcholine, make uterine contraction, spasmolytic, autonomic movement is reduced, lax gastrointestinal smooth muscle, suppress small intestinal spasmodic contraction, uterine smooth muscle is excited, immunomodulating, antiinflammatory, antiulcer, blood pressure lowering, intraocular pressure lowering, body-temp. reducing, prevention of arterial hardens, improve cerebral circulation, blood sugar lowering, blood fat reducing, anti peroxidation of lipid, free radical scavenging, function of gallbladder promoting, increase bile formed and promote the effects such as bilirubin discharge, clinically be used for the treatment of digestive system disease, as: esophagitis, gastroduodenal ulcer, atrophic gastritis, ileotyphus, ulcerative colitis, chronic cholecystitis etc.,
Endothelium Corneum Gigeriae Galli: removing food stagnancy is stagnant, strengthening the spleen and stomach, controls food stagnation distension, vomiting regurgitation, dysentery, and infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha, stopping leak essence, and hematuria, metrorrhagia, leukorrhagia, hemorrhoidal hamorrhage, dysentery.Control diseases due to endogenous heat of ZANG FU organs, reduce phlegm, regulate the flow of vital energy, dampness removing.
Cortex Magnoliae Officinalis: retention of dampness in middle-JIAO, distension and fullness in the abdomen, stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough, seven emotions pent-up, mental disorder mutual resistance, in pharynx if any thing resistance, pharynx not under, the globus hystericus disease do not gone out of telling.
Fructus Jujubae: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.Main trusted subordinate's pathogen, regulating the spleen and stomach supports spleen, helps 12 warps.Flat gastric qi, logical nine orifices, mends weak breath, few body fluid, not enough, frightened in body, heaviness of limbs, and hundred medicines;
The Pseudobulbus Bletillae (Rhizoma Bletillae): tonifying the lung, hemostasis, detumescence, granulation promoting, sore.Control lung and hinder hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, canker sores, and soup fire is burnt, rhagadia manus et pedis.Astringing to arrest bleeding, detumescence and promoting granulation.
Rhizoma Corydalis: blood-activating and qi-promoting, menstruction regulating and pain relieving, except wind, controls gas, warm waist knee joint, broken disease addiction, and flutter damage blood stasis, fall tire, and sudden and violent lumbago, promoting the circulation of QI, pain relieving, diuresis.
Propolis: propolis: bitter, acrid, cold, returns spleen, stomach warp, has anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, improves immunity, antiallergic is oxidized, the function of the gastrointestinal mucosa that stops blooding, protects.
All taste Chinese medicine is according to Chinese medical theory compatible combination above, for ulcerative colitis and clinical symptoms, plays the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, every drug synergism, has heat clearing and damp drying, eliminating fire and detoxication, dispersing cold for relieving pain, depressed liver-energy dispersing and QI regulating, removing stasis to stop bleeding, tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, promoting pus discharge and tissue regeneration strengthening, inducing diuresis to remove edema, the functions such as strengthening the spleen and nourishing the stomach, to treatment ulcerative colitis, good effect, instant effect, can reach the effect for the treatment of both the principal and secondary aspects of a disease, preparation is simple, and substep mixing is more even; Pure Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and draw materials wide, micronizing, bioavailability are high, curative effect highly significant.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting scope of the present invention.
Embodiment one
Treat a preparation method for the Chinese medicine composition of ulcerative colitis, concrete steps are as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Flos Chrysanthemi 10 parts, Pericarpium Citri Reticulatae 15 parts, Radix Curcumae 10 parts, Fructus Crataegi 10 parts, 5 parts, Radix Glycyrrhizae, Fructus Amomi 15 parts by weight, mix 5 minutes to even;
(3) take 20 parts, extra large Piao sheath, Rhizoma Coptidis 5 parts, Endothelium Corneum Gigeriae Galli 2 parts, Cortex Magnoliae Officinalis 15 parts, Fructus Jujubae 30 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Rhizoma Corydalis 20 parts, propolis 25 parts by weight, mix 5 minutes to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even, powder, tablet or pill can be made as required.
Embodiment two
Treat a preparation method for the Chinese medicine composition of ulcerative colitis, concrete steps are as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Flos Chrysanthemi 30 parts, Pericarpium Citri Reticulatae 25 parts, Radix Curcumae 30 parts, Fructus Crataegi 30 parts, 15 parts, Radix Glycyrrhizae, Fructus Amomi 25 parts by weight, mix 10 minutes to even;
(3) take 40 parts, extra large Piao sheath, Rhizoma Coptidis 15 parts, Endothelium Corneum Gigeriae Galli 8 parts, Cortex Magnoliae Officinalis 25 parts, Fructus Jujubae 50 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20 parts, Rhizoma Corydalis 30 parts, propolis 35 parts by weight, mix 10 minutes to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even, powder, tablet or pill can be made as required.
Embodiment three
Treat a preparation method for the Chinese medicine composition of ulcerative colitis, concrete steps are as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Flos Chrysanthemi 20 parts, Pericarpium Citri Reticulatae 20 parts, Radix Curcumae 20 parts, Fructus Crataegi 20 parts, 10 parts, Radix Glycyrrhizae, Fructus Amomi 20 parts by weight, mix 5-10 minute to even;
(3) take 30 parts, extra large Piao sheath, Rhizoma Coptidis 10 parts, Endothelium Corneum Gigeriae Galli 5 parts, Cortex Magnoliae Officinalis 20 parts, Fructus Jujubae 40 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, Rhizoma Corydalis 25 parts, propolis 30 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even, powder, tablet or pill can be made as required.
Embodiment four
Clinical observation:
Clinical observation treatment is carried out to 100 routine patients, wherein man 47, female 53, the age 21-40 year between, 35 years old mean age, course of disease 2-5, average 3.5 years.
The Chinese medicine composition consumption for the treatment of ulcerative colitis of the present invention is every day twice, each 5g, warm water delivery service, and period in a medicine prohibits raw food and irritable food, period in a medicine wine for giving off smoking, and pungent, stiff stodgy food.According to conditions of patients, patients with mild takes about 25 days, and severe patient serve on about 90 days.
Therapeutic effect:
| Therapeutic effect | Cure | Effective | Effectively | Invalid |
| Number of cases | 76 | 17 | 4 | 3 |
| Percentage ratio | 76％ | 17％ | 4％ | 3％ |
The present invention prepares simply, and good absorbing effect is evident in efficacy, and have no side effect, safety is high, is conducive to patient and alleviates condition of illness in time.
Above-mentioned detailed description of Chinese medicine composition for the treatment of ulcerative colitis and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (3)
1. treat a Chinese medicine composition for ulcerative colitis, it is characterized in that by following component mixed preparing by weight
2. the Chinese medicine composition for the treatment of ulcerative colitis according to claim 1, it is characterized in that by following component by weight mixed preparing form:
3. a preparation method for the Chinese medicine composition for the treatment of ulcerative colitis according to claim 1, is characterized in that concrete steps are as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Flos Chrysanthemi 10-30 part, Pericarpium Citri Reticulatae 15-25 part, Radix Curcumae 10-30 part, Fructus Crataegi 10-30 part, Radix Glycyrrhizae 5-15 part, Fructus Amomi 15-25 part by weight, mix 5-10 minute to even;
(3) take extra large Piao sheath 20-40 part, Rhizoma Coptidis 5-15 part, Endothelium Corneum Gigeriae Galli 2-8 part, Cortex Magnoliae Officinalis 15-25 part, Fructus Jujubae 30-50 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 part, Rhizoma Corydalis 20-30 part, propolis 25-35 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
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| CN105566029B (en) * | 2014-10-14 | 2017-09-29 | 中国石油化工股份有限公司 | A kind of method for reducing ethylene unit energy consumption |
| CN104436031A (en) * | 2014-11-17 | 2015-03-25 | 李先佳 | Medicine for treating ulcerative colitis |
| CN104740120A (en) * | 2015-02-12 | 2015-07-01 | 青岛静康医院 | Traditional Chinese medicine composition for dispelling wind and removing obstruction in the meridians as well as preparation method of traditional Chinese medicine composition and therapeutic equipment using traditional Chinese medicine combination |
| CN105012827A (en) * | 2015-07-25 | 2015-11-04 | 王璐 | Traditional Chinese drug treating colitis |
| CN105031501A (en) * | 2015-09-06 | 2015-11-11 | 张梅娟 | Composition for treating ulcerative colitis and preparing method thereof |
| CN105412609A (en) * | 2015-12-30 | 2016-03-23 | 张晓莉 | Traditional Chinese medicine for treating hepatic stagnation and spleen deficiency type ulcerative colitis and preparation method |
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| CN102631617A (en) * | 2012-04-02 | 2012-08-15 | 宋立 | Method for preparing traditional Chinese medicine (TCM) for treating greasy food overeating type colitis |
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| CN102631617A (en) * | 2012-04-02 | 2012-08-15 | 宋立 | Method for preparing traditional Chinese medicine (TCM) for treating greasy food overeating type colitis |
Non-Patent Citations (1)
| Title |
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| 南京中医药大学.白芨等.《中药大辞典》.上海科学技术出版社,2006,第940页. * |
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