CN109589372A - A kind of compound book on Chinese herbal medicine antibacterial liquid and preparation method thereof - Google Patents

A kind of compound book on Chinese herbal medicine antibacterial liquid and preparation method thereof Download PDF

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Publication number
CN109589372A
CN109589372A CN201910002853.1A CN201910002853A CN109589372A CN 109589372 A CN109589372 A CN 109589372A CN 201910002853 A CN201910002853 A CN 201910002853A CN 109589372 A CN109589372 A CN 109589372A
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parts
herbal medicine
chinese herbal
radix angelicae
mass fraction
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张美福
张印良
朱斌
廖肇林
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Jiangxi Qiankuntang Health Technology Co Ltd
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Jiangxi Qiankuntang Health Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K9/00—Medicinal preparations characterised by special physical form
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Abstract

The invention discloses a kind of compound book on Chinese herbal medicine antibacterial liquids and preparation method thereof, the effective component and its mass fraction that compound book on Chinese herbal medicine liquid is made is, 10-20 parts of olibanum, 30-55 parts of blood scorpion, 5-30 parts of decumbent corydalis tuber, 30-50 parts of Radix Angelicae Pubescentis, 20-50 parts of kuh-seng, 30-60 parts of honeysuckle, 5-30 parts of Radix Angelicae Sinensis, 10-25 parts of root of kirilow rhodiola, 10-30 parts of lopseed, 15-30 parts of folium isatidis, 10-40 parts of Herba Andrographitis, 20-55 parts of cordate houttuynia, 3-10 parts of acetic acid chlorhexidine, 3-10 parts of azone, it is impregnated 12 hours with the ethyl alcohol that mass fraction is 95%, it is heated to 65 degree of refluxing extractions twice, 4-6 times that quality is all the components gross mass is added to measure, and the ethyl alcohol that mass fraction is 95% extracts 1-2 hours, filtering, filter residue, quality, which is added, is The mass fraction water that 2-4 times of all the components gross mass is measured extracts 1-2 hours, and ethyl alcohol is recovered under reduced pressure to no alcohol taste, filtrate density 1.2 in filtering, merging filtrate.The invention has the advantages that small to skin irritation, easy to carry without harmful components, curative effect affirmative, treating both manifestation and root cause of disease, without side-effects, drug availability is high.

Description

A kind of compound book on Chinese herbal medicine antibacterial liquid and preparation method thereof
Technical field
The present invention relates to the preparation method technical field of antibacterial liquid formulation, more particularly to a kind of compound book on Chinese herbal medicine antibacterial liquid and Preparation method.
Background technique
Some skin diseases or traumatic skin infection, the condition of environment complexity can be inevitably encountered in people's life Under there are various bacteriums perhaps some bacterium of virus be to human body or skin it is harmful, especially skin goes out It is easy to be infected when the existing surface of a wound, such as Escherichia coli, staphylococcus aureus, Candida albicans, herpesviral.If These harmful bacterias or virus are directly or indirectly touched, less serious case generates pruitus, erythema etc., and severe one may be directly entered body Inside endanger the health of people.Therefore antibacterial liquid of the invention is developed.
Antibacterial liquid of the invention is small to skin irritation, without harmful components, family or go out travel and can take with oneself With spare, affected part is cleaned when there is skin infection, bacterial disease can be effectively isolated by smearing or spray antibacterial liquid of the invention Poison.
The present invention is the book on Chinese herbal medicine antibacterial liquid of compound always being mixed to prepare using traditional Chinese medicine ingredients and western medicine composition, applicable object Be: preventing and treating skin because of the skin diseases such as itch and erythema caused by direct infection or indirect infection, at the same effectively every From bacterium and virus.Application method: patient affected part Irrigation is clean, compound book on Chinese herbal medicine antibacterial liquid Direct Uniform of the present invention is applied In affected part, or it is sprayed on affected part, smears or spray twice within one day, be used continuously 3 days.
Summary of the invention
In order to solve the above-mentioned technical problems, the present invention provides a kind of compound book on Chinese herbal medicine antibacterial liquid and preparation method thereof the present invention Adopt the following technical scheme that a kind of compound book on Chinese herbal medicine antibacterial liquid, the effective component and its mass fraction that compound book on Chinese herbal medicine liquid is made are cream 10-20 parts fragrant, 30-55 parts of blood scorpion, 5-30 parts of decumbent corydalis tuber, 30-50 parts of Radix Angelicae Pubescentis, 20-50 parts of kuh-seng, 30-60 parts of honeysuckle, when Return 5-30 parts, 10-25 parts of root of kirilow rhodiola, 10-30 parts of lopseed, 15-30 parts of folium isatidis, 10-40 parts of Herba Andrographitis, cordate houttuynia 20-55 Part, 3-10 parts of acetic acid chlorhexidine, 3-10 parts of azone.
It is preferably made from the effective component and its mass fraction of compound book on Chinese herbal medicine liquid are as follows: 5-15 parts of olibanum, blood scorpion 40-55 Part, 15-30 parts of decumbent corydalis tuber, 35-40 parts of Radix Angelicae Pubescentis, 25-50 parts of kuh-seng, 35-50 parts of honeysuckle, 15-30 parts of Radix Angelicae Sinensis, root of kirilow rhodiola 15- 25 parts, 15-30 parts of lopseed, 20-30 parts of folium isatidis, 20-40 parts of Herba Andrographitis, 40-55 parts of cordate houttuynia, acetic acid chlorhexidine 3-5 Part, 5-10 parts of azone.
The effective component and its mass fraction for being preferably made from compound book on Chinese herbal medicine liquid are 20 parts of olibanum, 45 parts of blood scorpion, summer Without 20 parts, 30 parts of Radix Angelicae Pubescentis, 30 parts of kuh-seng, 40 parts of honeysuckle, 20 parts of Radix Angelicae Sinensis, 15 parts of root of kirilow rhodiola, 10 parts of lopseed, folium isatidis 25 Part, 30 parts of Herba Andrographitis, 45 parts of cordate houttuynia, 3 parts of acetic acid chlorhexidine, 3 parts of azone.
A kind of compound book on Chinese herbal medicine antibacterial liquid and preparation method thereof, preparation method includes the following steps；
(1) in power 1-3 ratio weigh olibanum, blood scorpion, decumbent corydalis tuber, Radix Angelicae Pubescentis, kuh-seng, honeysuckle, Radix Angelicae Sinensis, root of kirilow rhodiola, thoroughly Bone grass, folium isatidis, Herba Andrographitis, herba houttuyniae powder are broken to 80 mesh, are impregnated 12 hours with the ethyl alcohol that mass fraction is 95%, are heated to 65 It spends refluxing extraction twice, 4-6 times that quality is all the components gross mass is added for the first time and measures, and the ethyl alcohol that mass fraction is 95% It extracts 1-2 hours, filtering, filter residue, it is that the mass fraction water that 2-4 times of all the components gross mass is measured extracts 1- that second, which is added quality, 2 hours, ethyl alcohol was recovered under reduced pressure to no alcohol taste in filtering, merging filtrate, and concentrating the filtrate to density is 1.2；
(2) acetic acid chlorhexidine, azone are mixed in the Chinese medicine extract for being added and being concentrated, is stirred evenly；
(3) survey pH value 5.0~7.0, adjusted if high with 2mol/L hydrochloric acid solution, if it is low with 20% hydrogen-oxygen Change sodium solution adjustment；
(4) 120 DEG C, 30 minutes flowing steam sterilizations；
(5) filling under hundred-level laminar flow cover, both obtain the compound book on Chinese herbal medicine antibacterial liquid.
Compared with prior art, the present invention has the advantage that: antibacterial liquid of the present invention is directly used in Lesional Skin surface, neither The eupnea of skin can be interfered to be metabolized, and liquid contained drug can be made to be conveyed to rapidly and subcutaneously enter lesions position, to skin Irritation is small, easy to carry without harmful components, and curative effect affirmative, treating both manifestation and root cause of disease, without side-effects, drug availability is high, can prevent Cause the skin diseases such as itch and erythema because of direct infection or indirect infection with treatment skin, at the same can effectively be isolated bacterium and Virus.
Specific embodiment
The preferred embodiment of the present invention is described in detail below so that advantages and features of the invention can be easier to by It will be appreciated by those skilled in the art that so as to make a clearer definition of the protection scope of the present invention.
Embodiment 1
The compound book on Chinese herbal medicine antibacterial liquid of present embodiment be by olibanum, blood scorpion, decumbent corydalis tuber, Radix Angelicae Pubescentis, kuh-seng, honeysuckle, Radix Angelicae Sinensis, Root of kirilow rhodiola, lopseed, folium isatidis, Herba Andrographitis, cordate houttuynia, acetic acid chlorhexidine, azone are the suppression of compound book on Chinese herbal medicine made from primary raw material Bacterium solution.Effective component and its mass fraction are as follows: 10 parts of olibanum, 30 parts of blood scorpion, 5 parts of decumbent corydalis tuber, 35 parts of Radix Angelicae Pubescentis, 20 parts of kuh-seng, gold 35 parts of honeysuckle flower, 5 parts of Radix Angelicae Sinensis, 10 parts of root of kirilow rhodiola, 10 parts of lopseed, 15 parts of folium isatidis, 10 parts of Herba Andrographitis, 20 parts of cordate houttuynia, acetic acid 5 parts of chlorhexidine, 3 parts of azone.
The preparation method of the compound book on Chinese herbal medicine antibacterial liquid the following steps are included:
(1) in power 1-3 ratio weigh olibanum, blood scorpion, decumbent corydalis tuber, Radix Angelicae Pubescentis, kuh-seng, honeysuckle, Radix Angelicae Sinensis, root of kirilow rhodiola, thoroughly Bone grass, folium isatidis, Herba Andrographitis, herba houttuyniae powder are broken to 80 mesh, are impregnated 12 hours with the ethyl alcohol that mass fraction is 95%, are heated to 65 It spends refluxing extraction twice, 4-6 times that quality is all the components gross mass is added for the first time and measures, and the ethyl alcohol that mass fraction is 95% It extracts 1-2 hours, filtering, filter residue, it is that the mass fraction water that 2-4 times of all the components gross mass is measured extracts 1- that second, which is added quality, 2 hours, ethyl alcohol was recovered under reduced pressure to no alcohol taste in filtering, merging filtrate, and concentrating the filtrate to density is 1.2；
(2) acetic acid chlorhexidine, azone are mixed in the Chinese medicine extract for being added and being concentrated, is stirred evenly；
(3) survey pH value 5.0~7.0, adjusted if high with 2mol/L hydrochloric acid solution, if it is low with 20% hydroxide Sodium solution adjustment；
(4) 120 DEG C, 30 minutes flowing steam sterilizations；
(5) filling under hundred-level laminar flow cover, both obtain the compound book on Chinese herbal medicine antibacterial liquid.
Embodiment 2
The compound book on Chinese herbal medicine antibacterial liquid of present embodiment be by olibanum, blood scorpion, decumbent corydalis tuber, Radix Angelicae Pubescentis, kuh-seng, honeysuckle, Radix Angelicae Sinensis, Root of kirilow rhodiola, lopseed, folium isatidis, Herba Andrographitis, cordate houttuynia, acetic acid chlorhexidine, azone are the suppression of compound book on Chinese herbal medicine made from primary raw material Bacterium solution.Effective component and its mass fraction are as follows: 15 parts of olibanum, 55 parts of blood scorpion, 30 parts of decumbent corydalis tuber, 40 parts of Radix Angelicae Pubescentis, 50 parts of kuh-seng, gold 50 parts of honeysuckle flower, 30 parts of Radix Angelicae Sinensis, 25 parts of root of kirilow rhodiola, 30 parts of lopseed, 30 parts of folium isatidis, 40 parts of Herba Andrographitis, 55 parts of cordate houttuynia, acetic acid 3 parts of chlorhexidine, 3 parts of azone.
The preparation method of the compound book on Chinese herbal medicine antibacterial liquid the following steps are included:
(1) in power 1-3 ratio weigh olibanum, blood scorpion, decumbent corydalis tuber, Radix Angelicae Pubescentis, kuh-seng, honeysuckle, Radix Angelicae Sinensis, root of kirilow rhodiola, thoroughly Bone grass, folium isatidis, Herba Andrographitis, herba houttuyniae powder are broken to 80 mesh, are impregnated 12 hours with the ethyl alcohol that mass fraction is 95%, are heated to 65 It spends refluxing extraction twice, 4-6 times that quality is all the components gross mass is added for the first time and measures, and the ethyl alcohol that mass fraction is 95% It extracts 1-2 hours, filtering, filter residue, it is that the mass fraction water that 2-4 times of all the components gross mass is measured extracts 1- that second, which is added quality, 2 hours, ethyl alcohol was recovered under reduced pressure to no alcohol taste in filtering, merging filtrate, and concentrating the filtrate to density is 1.2；
(2) acetic acid chlorhexidine, azone are mixed in the Chinese medicine extract for being added and being concentrated, is stirred evenly；
(3) survey pH value 5.0~7.0, adjusted if high with 2mol/L hydrochloric acid solution, if it is low with 20% hydrogen-oxygen Change sodium solution adjustment；
(4) 120 DEG C, 30 minutes flowing steam sterilizations；
(5) filling under hundred-level laminar flow cover, both obtain the compound book on Chinese herbal medicine antibacterial liquid.
Embodiment 3
The compound book on Chinese herbal medicine antibacterial liquid of present embodiment be by olibanum, blood scorpion, decumbent corydalis tuber, Radix Angelicae Pubescentis, kuh-seng, honeysuckle, Radix Angelicae Sinensis, Root of kirilow rhodiola, lopseed, folium isatidis, Herba Andrographitis, cordate houttuynia, acetic acid chlorhexidine, azone are the suppression of compound book on Chinese herbal medicine made from primary raw material Bacterium solution.Effective component and its mass fraction are as follows: 15 parts of olibanum, 45 parts of blood scorpion, 20 parts of decumbent corydalis tuber, 30 parts of Radix Angelicae Pubescentis, 30 parts of kuh-seng, gold 40 parts of honeysuckle flower, 20 parts of Radix Angelicae Sinensis, 15 parts of root of kirilow rhodiola, 10 parts of lopseed, 25 parts of folium isatidis, 30 parts of Herba Andrographitis, 45 parts of cordate houttuynia, acetic acid 3 parts of chlorhexidine, 3 parts of azone.
The preparation method of the compound book on Chinese herbal medicine antibacterial liquid the following steps are included:
(1) in power 1-3 ratio weigh olibanum, blood scorpion, decumbent corydalis tuber, Radix Angelicae Pubescentis, kuh-seng, honeysuckle, Radix Angelicae Sinensis, root of kirilow rhodiola, thoroughly Bone grass, folium isatidis, Herba Andrographitis, herba houttuyniae powder are broken to 80 mesh, are impregnated 12 hours with the ethyl alcohol that mass fraction is 95%, are heated to 65 It spends refluxing extraction twice, 4-6 times that quality is all the components gross mass is added for the first time and measures, and the ethyl alcohol that mass fraction is 95% It extracts 1-2 hours, filtering, filter residue, it is that the mass fraction water that 2-4 times of all the components gross mass is measured extracts 1- that second, which is added quality, 2 hours, ethyl alcohol was recovered under reduced pressure to no alcohol taste in filtering, merging filtrate, and concentrating the filtrate to density is 1.2；
(2) acetic acid chlorhexidine, azone are mixed in the Chinese medicine extract for being added and being concentrated, is stirred evenly；
(3) survey pH value 5.0~7.0, adjusted if high with 2mol/L hydrochloric acid solution, if it is low with 20% hydrogen-oxygen Change sodium solution adjustment；
(4) 120 DEG C, 30 minutes flowing steam sterilizations；
(5) filling under hundred-level laminar flow cover, both obtain the compound book on Chinese herbal medicine antibacterial liquid.
Compound book on Chinese herbal medicine antibacterial liquid prepared by this specific embodiment 1 to 3 is used for In Vitro Bacteriostasis below and stability test, Its result is as follows:
1, In Vitro Bacteriostasis comparative test: commercially available Traditional Chinese medicine bacteriostatic liquid and compound Chinese and Western medicine antibacterial liquid are taken, with golden yellow grape Three kinds of drugs are diluted as test organisms with doubling dilution by coccus, and as a result the minimal inhibitory concentration of this product is commercially available The 1/4 of herbal mixture antibacterial liquid is the 3/1 of compound Chinese and Western medicine antibacterial liquid.This result shows that, show this product from laboratory test Curative effect be better than commercially available herbal mixture antibacterial liquid and compound Chinese and Western medicine antibacterial liquid.
2, the stability test of product: compound draft antibacterial liquid of the invention is stored under 40 DEG C of environment temperature, is led to Observation and detection in 6 months are crossed, as a result, it has been found that the compound draft antibacterial liquid of embodiment 1 is unchanged through six months storage colors, Wherein active constituent content decline is only 1.2%, and the compound draft antibacterial liquid of embodiment 3 is through six months storage colors also without change Change, wherein active constituent content decline be only 1.5%, comparison it is found that the compound draft antibacterial liquid shelf-life of embodiment 1 and 3 not Lower than regulation validity period 2 years.
Not limited to this, any change or replacement expected without creative work should all be covered in guarantor of the invention Within the scope of shield.Therefore, protection scope of the present invention should be determined by the scope of protection defined in the claims.

Claims (4)

1. a kind of compound book on Chinese herbal medicine antibacterial liquid, which is characterized in that the effective component and its mass fraction that compound book on Chinese herbal medicine liquid is made are cream 10-20 parts fragrant, 30-55 parts of blood scorpion, 5-30 parts of decumbent corydalis tuber, 30-50 parts of Radix Angelicae Pubescentis, 20-50 parts of kuh-seng, 30-60 parts of honeysuckle, Radix Angelicae Sinensis 5-30 parts, 10-25 parts of root of kirilow rhodiola, 10-30 parts of lopseed, 15-30 parts of folium isatidis, 10-40 parts of Herba Andrographitis, 20-55 parts of cordate houttuynia, 3-10 parts of acetic acid chlorhexidine, 3-10 parts of azone.
2. compound book on Chinese herbal medicine antibacterial liquid according to claim 1, which is characterized in that be made compound book on Chinese herbal medicine liquid effective component and Its mass fraction are as follows: 5-15 parts of olibanum, 40-55 parts of blood scorpion, 15-30 parts of decumbent corydalis tuber, 35-40 parts of Radix Angelicae Pubescentis, 25-50 parts of kuh-seng, gold 35-50 parts of honeysuckle flower, 15-30 parts of Radix Angelicae Sinensis, 15-25 parts of root of kirilow rhodiola, 15-30 parts of lopseed, 20-30 parts of folium isatidis, Herba Andrographitis 20-40 Part, 40-55 parts of cordate houttuynia, 3-5 parts of acetic acid chlorhexidine, 5-10 parts of azone.
3. compound book on Chinese herbal medicine antibacterial liquid according to claim 1, which is characterized in that be made compound book on Chinese herbal medicine liquid effective component and Its mass fraction is 20 parts of olibanum, 45 parts of blood scorpion, 20 parts of decumbent corydalis tuber, 30 parts of Radix Angelicae Pubescentis, 30 parts of kuh-seng, 40 parts of honeysuckle, Radix Angelicae Sinensis 20 Part, 15 parts of root of kirilow rhodiola, 10 parts of lopseed, 25 parts of folium isatidis, 30 parts of Herba Andrographitis, 45 parts of cordate houttuynia, 3 parts of acetic acid chlorhexidine, azone 3 Part.
4. compound book on Chinese herbal medicine antibacterial liquid according to claim 1 to 3 and preparation method thereof, which is characterized in that it is made Preparation Method includes the following steps；
(1) in power 1-3 ratio weigh olibanum, blood scorpion, decumbent corydalis tuber, Radix Angelicae Pubescentis, kuh-seng, honeysuckle, Radix Angelicae Sinensis, root of kirilow rhodiola, lopseed, Folium isatidis, Herba Andrographitis, herba houttuyniae powder are broken to 80 mesh, are impregnated 12 hours with the ethyl alcohol that mass fraction is 95%, are heated to 65 degree and return Stream extracts twice, and 4-6 times that quality is all the components gross mass is added for the first time and measures, and the ethyl alcohol that mass fraction is 95% extracts 1-2 hours, filtering, filter residue, it was that the mass fraction water extraction 1-2 that 2-4 times of all the components gross mass is measured is small that second, which is added quality, When, ethyl alcohol is recovered under reduced pressure to no alcohol taste in filtering, merging filtrate, and concentrating the filtrate to density is 1.2；
(2) acetic acid chlorhexidine, azone are mixed in the Chinese medicine extract for being added and being concentrated, is stirred evenly；
(3) pH value 5.0~7.0 is surveyed, is adjusted if high with 2mol/L hydrochloric acid solution, if low molten with 20% sodium hydroxide Liquid adjustment；
(4) 120 DEG C, 30 minutes flowing steam sterilizations；
(5) filling under hundred-level laminar flow cover, both obtain the compound book on Chinese herbal medicine antibacterial liquid.
CN201910002853.1A 2019-01-02 2019-01-02 A kind of compound book on Chinese herbal medicine antibacterial liquid and preparation method thereof Pending CN109589372A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1302638A (en) * 2000-01-01 2001-07-11 同济医科大学附属同济医院 Anti-infection Chinese medicine for clearing heat and detoxicating and its preparing process
CN102048927A (en) * 2011-01-13 2011-05-11 中国人民解放军第四军医大学 Chinese medical compound preparation for treating skin injury and the preparation method and application thereof
CN106728264A (en) * 2015-11-20 2017-05-31 杨福臣 A kind of removing miliaria and relieving itching powder
CN108245602A (en) * 2018-04-18 2018-07-06 张国壮 It is a kind of to treat dermopathic external medicine composition
CN108553608A (en) * 2018-05-30 2018-09-21 武汉润禾生物医药有限公司 A kind of bacteriostatic gel and preparation method thereof for treating vulval dermatitis itch

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1302638A (en) * 2000-01-01 2001-07-11 同济医科大学附属同济医院 Anti-infection Chinese medicine for clearing heat and detoxicating and its preparing process
CN102048927A (en) * 2011-01-13 2011-05-11 中国人民解放军第四军医大学 Chinese medical compound preparation for treating skin injury and the preparation method and application thereof
CN106728264A (en) * 2015-11-20 2017-05-31 杨福臣 A kind of removing miliaria and relieving itching powder
CN108245602A (en) * 2018-04-18 2018-07-06 张国壮 It is a kind of to treat dermopathic external medicine composition
CN108553608A (en) * 2018-05-30 2018-09-21 武汉润禾生物医药有限公司 A kind of bacteriostatic gel and preparation method thereof for treating vulval dermatitis itch

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