CN105708763B - A kind of floral water containing Folium Artemisiae Argyi extract and preparation method thereof - Google Patents
A kind of floral water containing Folium Artemisiae Argyi extract and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention belongs to household chemicals technical field, and in particular to a kind of floral water containing Folium Artemisiae Argyi extract and preparation method thereof, the floral water containing Folium Artemisiae Argyi extract includes the preparing raw material of following parts by weight：4 10 parts of Folium Artemisiae Argyi extract, 10 20 parts of Negundo Chastetree Leaf, 8 15 parts of basyleave, 12 25 parts of purslane, 8 16 parts of dandelion, 7 15 parts of Asiatic plantain, 5 12 parts of sealwort, 28 parts of isopropyl palmitate, 60 70 parts of ethanol.Floral water action temperature provided by the invention containing Folium Artemisiae Argyi extract and, skin irritation is small, is improved using comfort, and repelling effect is notable, mosquito repellent effectiveness time length, while also has the significant antibacterial and effect of repellent antipruritic.
Description
Technical field
The invention belongs to household chemicals technical field, and in particular to a kind of floral water and its system containing Folium Artemisiae Argyi extract
Preparation Method.
Background technology
Mosquito is in addition to people's blood is sucked, or one of important vector, it carries a variety of pathogenic microorganisms, is stung by mosquito in vivo
After stinging, red swelling of the skin, itch are not only caused, it is also possible to a variety of diseases are transmitted, such as dengue fever, malaria, Japanese Type-B encephalitis
Deng serious harm human health.Floral water has easy to use, special from the limiting of time and use condition, easy to carry etc.
Point, is a kind of mosquito repellent product of relative ideal, therefore is had deep love for extensively be subject to people.
The main active of floral water is mostly conventional synthesis culicifuge currently on the market, such as dimethyl phthalate (BAAPE), neighbour
Rutgers (DMP), Metadelphene (DEET) etc..But there are studies have shown that dimethyl phthalate and Metadelphene that there is toxic side effect,
During use, people absorb part dimethyl phthalate by alimentary canal, respiratory tract, can not only induce the diseases such as asthma, long-time service
Can also carcinogenic, teratogenesis；Metadelphene can cause children's encephalopathic, nettle rash syndrome, allergic reaction, blood pressure are low and heartbeat reduces etc..
Therefore, developing the culicifuge of natural source becomes the terminal studied at present.Now some researches show that various plants extract is good according to having
Repelling effect, such as citronella oil, nim oil, eucalyptus oil, basil, peppermint oil, caryophyllus oil, lemon oil.
Chinese patent CN103432051B discloses a kind of mosquito-expelling and antipruritic floral water, including in parts by weight as follows
Raw material：2-4 parts of Lavender, 6-10 parts of P-Cymene, 5-7 parts of eucalyptus leaf essential oil, 10-15 parts of peppermint, 12-18 parts of wild chrysanthemum,
5-8 parts of propolis, 80-100 parts of deionized water, 1-4 parts of emulsifying agent.The floral water has a good repelling effect, long action time,
But its antipruritic effect is not notable.
In order to reach refrigerant and repellent antipruritic effect, the floral water of existing market usually also adds menthol and salicylic acid,
There is irritation to skin, while also add the drying property of skin, therefore, the usage comfort of existing floral water needs to be carried
It is high.
The content of the invention
For overcome the deficiencies in the prior art, the present invention provides a kind of floral water containing Folium Artemisiae Argyi extract.The present invention
The floral water containing Folium Artemisiae Argyi extract provided is in addition to significant repelling effect, also with antibacterial and repellent antipruritic effect
Fruit.The floral water action temperature containing Folium Artemisiae Argyi extract of the invention and, skin irritation is small, feels after use without dry skin, uses
Comfort level improves, while its mosquito repellent effectiveness time is grown.
The technical solution that the present invention solves above-mentioned technical problem is as follows：
A kind of floral water containing Folium Artemisiae Argyi extract, includes the preparing raw material of following parts by weight：4-10 parts of Folium Artemisiae Argyi extract,
10-20 parts of Negundo Chastetree Leaf, 8-15 parts of basyleave, 12-25 parts of purslane, 8-16 parts of dandelion, 7-15 parts of Asiatic plantain, sealwort 5-12
Part, 2-8 parts of isopropyl palmitate, 60-70 parts of ethanol.
In the range of above parts by weight, preferably 3 effects are than more prominent formula：
Formula 1：8 parts of Folium Artemisiae Argyi extract, 18 parts of Negundo Chastetree Leaf, 15 parts of basyleave, 20 parts of purslane, 10 parts of dandelion, Chinese herbaceous peony
12 parts of grass, 10 parts of sealwort, 4 parts of isopropyl palmitate, 65 parts of ethanol.
Formula 2：6 parts of Folium Artemisiae Argyi extract, 12 parts of Negundo Chastetree Leaf, 12 parts of basyleave, 25 parts of purslane, 12 parts of dandelion, Chinese herbaceous peony
15 parts of grass, 8 parts of sealwort, 7 parts of isopropyl palmitate, 70 parts of ethanol.
Formula 3：5 parts of Folium Artemisiae Argyi extract, 10 parts of Negundo Chastetree Leaf, 10 parts of basyleave, 15 parts of purslane, 16 parts of dandelion, Chinese herbaceous peony
10 parts of grass, 12 parts of sealwort, 5 parts of isopropyl palmitate, 60 parts of ethanol.
Preferably, the volume fraction of the ethanol is 45%-60%.
Preferably, the preparation method of the Folium Artemisiae Argyi extract comprises the following steps：
Dry folium artemisiae argyi is taken, the sodium chloride solution that 6-10 times of its weight is measured is added after crushing, 30-45min is soaked, in 400-
Microwave treatment 2-5min under the power of 450W, steam distillation 1-3h, collect distillate, up to Folium Artemisiae Argyi extract.
Preferably, in the preparation method of the Folium Artemisiae Argyi extract, the mass fraction of sodium chloride solution is 2-6%.
The floral water containing Folium Artemisiae Argyi extract of the invention using natural plant extracts as active ingredient, for mosquito repellent, it is antibacterial,
It is antipruritic safe and effective.Wherein, folium artemisiae argyi is the leaf of composite family herbaceos perennial Chinese mugwort, containing volatile aromatic oil, produced by it
Peculiar fragrance, can mosquito repellent fly, worm ant.Volatile argyi leaf oil be Folium Artemisiae Argyi extract in main component, its component include eucalyptol,
Terpinol, 1, 8-Cineole, α-thujene, borneol, eugenol, palmitic acid etc., in addition, also containing flavones in Folium Artemisiae Argyi extract
The compounds such as class, triterpenes, trace element and tannin, in addition to repelling effect, also with significant fungistatic effect, go back at the same time
Acted on anti-inflammatory, antiallergy etc..Negundo Chastetree Leaf is the leaf of Verbenaceae five-leaved chaste tree, is waved containing eucalyptol, 1- sabinenes, amphene etc.
Hair oil component and casticin, cyanidenon -7- glycosides, P-hydroxybenzoic acid, 5- hydroxyls iso-phthalic acid and Chinese mugwort are yellow
The chemical compositions such as element, it is antipruritic and other effects with inducing diaphoresis heat dissipation, eliminating damp, detoxifying, desinsection.Basyleave is the leaf of canella bay, is contained
Aromatic oil, its main component include fragrant and mellow camphor tree, Eugenol, 1, 8-Cineole, terpinol and acetyleugenol etc., have and drive
Mosquito effect.Purslane herb contains a large amount of norepinephrines and volume sylvite, also containing dopamine, dihydroxyphenylalanine, apple
The component such as tartaric acid, citric acid, Glutamic Acid, aspartic acid, vitamin A, B, C, has removing toxic substances, inhibiting bacteria and diminishing inflammation, miliaria and other effects of dispelling；Grind
Study carefully and show, purslane ethanol extract has Escherichia coli, proteus, shigella dysenteriae, typhoid fever, paratyphosum Bacterium the suppression of height
Make and use, also there is different degrees of suppression to make to staphylococcus aureus, fungi such as microsporum audouini, tubercle bacillus
With.Dandelion is the drying herb of feverfew dandelion, containing taraxasterol, choline, synanthrin, taraxol, pectin and dimension
Raw element etc., has clearing heat and detoxicating, dispersing swelling and dissipating binds and other effects, significant curative effect is respectively provided with for a variety of skin diseases, can improve eczema,
Inflammation is soothed the skin, while can also be used to treat dry skin etc..Asiatic plantain is the drying herb of plantago plant Chinese herbaceous peony, containing black bearberry
Acid, cupreol, β-paddy alcohol palmitate, Syring vulgaris phenol glucoside, Chinese herbaceous peony glycosides displayed, moon stachyose, sucrose, gossypose etc., have
Resisting pathogenic microbes and anti-inflammatory and other effects.Sealwort is the dry rhizome of liliaceous plant P. kingianum, modern research shows that it has
Resisting pathogenic microbes, antifatigue, anti-oxidant and delaying senility function.The present invention using Folium Artemisiae Argyi extract, Negundo Chastetree Leaf and basyleave as
The component such as main anophelifuge activity component, compounding purslane, Asiatic plantain, dandelion, sealwort, isopropyl palmitate and ethanol, respectively into
Divide synergistic effect, in addition to significant repelling effect, also with antibacterial and repellent antipruritic effect, while can also improve liquid distilled from honeysuckle flowers or lotus leaves
The usage comfort of water.
Meanwhile the present invention also provides a kind of preparation method of the floral water of the present invention containing Folium Artemisiae Argyi extract, including
Following steps：
S1：Dry folium artemisiae argyi is taken, it is 2-6% sodium chloride solutions that the mass fraction that 6-10 times of its weight is measured is added after crushing,
Soak 30-45min, the microwave treatment 2-5min under the power of 400-450W, steam distillation 1-3h, collect distillate, to obtain the final product
Folium Artemisiae Argyi extract；
S2：Negundo Chastetree Leaf, basyleave, purslane, dandelion, Asiatic plantain and sealwort are taken, coarse powder gross weight 8- is added after crushing
The ethanol that 12 times of amount volume fractions are 70-85%, when immersion 3-6 is small, ultrasonic extraction 30-45 minutes at a temperature of 40-60 DEG C, surpasses
Acoustic frequency is 20-30kHz, filtering；Filter residue adds 6-10 times of coarse powder gross weight and measures the ethanol that volume fraction is 70-85%, in 40-
Ultrasonic extraction 30-45 minutes, supersonic frequency 20-30kHz at a temperature of 60 DEG C, filtering；Merging filtrate, filtrate decompression are distilled to recover
Ethanol, is concentrated into the concentrate that relative density at 60 DEG C is 1.02-1.06g/mL；
S3：Concentrate 1200-1500r/min is centrifuged into 8-15min, it with molecular cut off is 10000- to take supernatant
30000 PS membrane carries out ultrafiltration, and it is 1.20-1.30g/mL that ultrafiltrate, which is concentrated under reduced pressure into relative density at 60 DEG C, up to Chinese medicine
Extracting solution；
S4：Chinese medicine extract described in Folium Artemisiae Argyi extract, S3 and isopropyl palmitate are added in ethanol, are uniformly mixed, i.e.,
.
Preferably, in the step S3, ultra-filtration conditions are inlet pressure 0.30-0.40MPa, liquid outlet 0.25-
0.35MPa, 35-40 DEG C of feed temperature, feed velocity 2.0-3.0m/s.
Compared with prior art, the beneficial effects of the present invention are：
(1) for the floral water provided by the invention containing Folium Artemisiae Argyi extract using natural plant extracts as main component, poison is secondary
Act on low, each component synergistic effect, with significant mosquito repellent, antibacterial and repellent antipruritic and other effects；
(2) floral water provided by the invention containing Folium Artemisiae Argyi extract is free of the stimulating components such as menthol and salicylic acid,
Also reduce the concentration of ethanol at the same time, there is repellent antipruritic and do not stimulate the effect of skin, action temperature and, improve what is used
Comfort level, using rear skin without dry sensation；
(3) repelling effect test result is shown, the floral water provided by the invention containing Folium Artemisiae Argyi extract is to aedes albopictus
Effective protecting time reach more than 8h.
Embodiment
The present invention is further described below by way of embodiment, but the present invention is not limited only to following embodiments.
In the scope of the present invention or do not departing from present disclosure, in spirit and scope, the present invention is suitably modified, is replaced
The identical component of effect, it will become apparent to those skilled in the art that they are considered as being included in the present invention's
Within the scope of.
The floral water of the invention containing Folium Artemisiae Argyi extract of embodiment 1
Floral water of the embodiment of the present invention 1 containing Folium Artemisiae Argyi extract, includes the preparing raw material of following parts by weight：Folium artemisiae argyi is extracted
8 parts of thing, 18 parts of Negundo Chastetree Leaf, 15 parts of basyleave, 20 parts of purslane, 10 parts of dandelion, 12 parts of Asiatic plantain, 10 parts of sealwort, palmitic acid
4 parts of isopropyl ester, 65 parts of ethanol.
Preparation method：
S1：Dry folium artemisiae argyi is taken, the mass fraction that 8 times of amounts of its weight are added after crushing is 4% sodium chloride solution, immersion
30min, the microwave treatment 3min under the power of 420W, steam distillation 2h, collect distillate, up to Folium Artemisiae Argyi extract；
S2：Negundo Chastetree Leaf, basyleave, purslane, dandelion, Asiatic plantain and sealwort are taken, coarse powder gross weight 10 is added after crushing
The ethanol that amount volume fraction is 75% again, when immersion 4 is small, ultrasonic extraction 40 minutes, supersonic frequency are at a temperature of 45 DEG C
27kHz, filtering；Filter residue adds the ethanol that 8 times of amount volume fractions of coarse powder gross weight are 75%, the ultrasonic extraction 30 at a temperature of 45 DEG C
Minute, supersonic frequency 27kHz, filtering；Merging filtrate, filtrate decompression are distilled to recover ethanol, are concentrated into relative density at 60 DEG C
For the concentrate of 1.02g/mL；
S3：Concentrate 1500r/min is centrifuged into 10min, takes supernatant to be carried out with the PS membrane that molecular cut off is 20000
Ultrafiltration, ultra-filtration conditions are inlet pressure 0.35MPa, and liquid outlet 0.30MPa, 40 DEG C, feed velocity 2.0m/s of feed temperature, surpasses
It is 1.25g/mL that filtrate decompression, which is concentrated into relative density at 60 DEG C, up to Chinese medicine extract；
S4：Chinese medicine extract described in Folium Artemisiae Argyi extract, S3 and isopropyl palmitate are added in ethanol, are uniformly mixed, i.e.,
.
The floral water of the invention containing Folium Artemisiae Argyi extract of embodiment 2
Floral water of the embodiment of the present invention 2 containing Folium Artemisiae Argyi extract, includes the preparing raw material of following parts by weight：Folium artemisiae argyi is extracted
6 parts of thing, 12 parts of Negundo Chastetree Leaf, 12 parts of basyleave, 25 parts of purslane, 12 parts of dandelion, 15 parts of Asiatic plantain, 8 parts of sealwort, palmitic acid is different
7 parts of propyl ester, 70 parts of ethanol.
Preparation method is the same as embodiment 1.
The floral water of the invention containing Folium Artemisiae Argyi extract of embodiment 3
Floral water of the embodiment of the present invention 3 containing Folium Artemisiae Argyi extract, includes the preparing raw material of following parts by weight：Folium artemisiae argyi is extracted
5 parts of thing, 10 parts of Negundo Chastetree Leaf, 10 parts of basyleave, 15 parts of purslane, 16 parts of dandelion, 10 parts of Asiatic plantain, 12 parts of sealwort, palmitic acid
5 parts of isopropyl ester, 60 parts of ethanol.
Preparation method is the same as embodiment 1.
Comparative example 1
Floral water of the comparative example 1 containing Folium Artemisiae Argyi extract, includes the preparing raw material of following parts by weight：8 parts of Folium Artemisiae Argyi extract,
18 parts of Negundo Chastetree Leaf, 15 parts of basyleave, 20 parts of purslane, 15 parts of dandelion, 12 parts of Asiatic plantain, 4 parts of isopropyl palmitate, ethanol 65
Part.
Preparation method is the same as embodiment 1.
Comparative example 2
Floral water of the comparative example 1 containing Folium Artemisiae Argyi extract, includes the preparing raw material of following parts by weight：8 parts of Folium Artemisiae Argyi extract,
18 parts of Negundo Chastetree Leaf, 15 parts of basyleave, 20 parts of honeysuckle, 10 parts of dandelion, 12 parts of Asiatic plantain, 10 parts of sealwort, isopropyl palmitate 4
Part, 65 parts of ethanol.
Preparation method is the same as embodiment 1.
Test example one, repelling effect test
1st, test specimen：Floral water prepared by 1-3 of the embodiment of the present invention, comparative example 1-2, six refreshing mosquito-repellent perfume (Shanghai
Jia Hua Allied Corp. (US) Law Department 401 N. Bendix Drive, P.O. Box 4001 South Bend, 195mL/ bottles).
2nd, for test worm kind and strain：Aedes albopictus (Aedes albopictus), the sensitive strain standard of laboratory rearing
Test worm, -5 days 3 days female insects do not sucked blood after emergence.
3rd, test method：According to GB/T 13917.9-2009 (《Agriculture chemical registration with hygienic insecticide indoor pharmacodynamic test and
Evaluate the 9th part：Repellant》) test method tested, wherein, every group of repellency test selection 20 attack is qualified
Volunteer is tested, and men and women is fifty-fifty.
4th, result of the test, is shown in Table 1.
Effective protecting time of 1 floral water of table to volunteer
| Sample | Effective protecting time (h) |
| Embodiment 1 | 10.2 |
| Embodiment 2 | 9.4 |
| Embodiment 3 | 8.8 |
| Comparative example 1 | 4.6 |
| Comparative example 2 | 5.5 |
| Six refreshing mosquito-repellent perfumes | 6.2 |
It is notable by floral water repelling effect of the above-mentioned results showed that present invention containing Folium Artemisiae Argyi extract, to volunteer
Effective protecting time be up to more than 8h, repelling effect is better than positive controls.Compared with 1 group of the embodiment of the present invention, comparative example 1
Group of formula improves the dosage of dandelion but does not add sealwort, and 2 group of formula of comparative example honeysuckle similar in effect replaces this hair
Purslane in the bright formula of embodiment 1,2 groups of effective protecting times to volunteer of 1 group of comparative example and comparative example are substantially reduced, driven
Mosquito effect is not so good as 1 group of the embodiment of the present invention, illustrates each component synergistic effect of the floral water of the invention containing Folium Artemisiae Argyi extract, has
Significant repelling effect, wherein, the floral water repelling effect that the embodiment of the present invention 1 is prepared is the most notable.
Test example two, repellent antipruritic experiment
1st, test method：Select by the volunteer 240 of bite by mosquitos, wherein man 132, female 108, the age is in 12-
56 years old, 6 groups are randomly divided into by the principle of parallel control, every group of 40 people, are respectively embodiment 1-3 groups, comparative example 1-2 groups and the positive
Control group (compound menthol Ointment, Chinese medicines quasi-word H20013294a, The Mentholatum Company).Bite by mosquitos
After skin, take floral water or ointment to be uniformly applied at red swelling of the skin, smear dosage and adjusted according to Tumor size, and record liquid distilled from honeysuckle flowers or lotus leaves
Volunteer's number of cases that antipruritic effect works in the effect of water or ointment repellent antipruritic and 3min.
2nd, therapeutic evaluation：
It is effective：Red swelling of the skin, heat, pain, symptom of itching rapid regression；
Generally：Red swelling of the skin, heat, pain, symptom of itching mitigate；
It is invalid：Repellent antipruritic effect unobvious or exacerbation.
3rd, result of the test：It is shown in Table 2 and table 3.
Antipruritic effect action volunteer's number of cases in 2 3min of table
| Group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Positive controls |
| Number of cases | 37 | 40 | 35 | 25 | 18 | 32 |
3 therapeutic evaluation of table
| Group | Effective (rate) | Effectively | It is invalid | Total effective rate |
| Embodiment 1 | 31 (77.5%) | 8 | 1 | 97.5% |
| Embodiment 2 | 34 (85%) | 6 | 0 | 100% |
| Embodiment 3 | 29 (72.5%) | 10 | 1 | 97.5% |
| Comparative example 1 | 21 (52.5%) | 12 | 7 | 82.5% |
| Comparative example 2 | 16 (40%) | 11 | 13 | 67.5% |
| Positive controls | 25 (62.5%) | 12 | 3 | 92.5% |
The skin as caused by above-mentioned floral water of the results showed that present invention containing Folium Artemisiae Argyi extract for bite by mosquitos
Red and swollen, heat, pain, symptom of itching have significant repellent antipruritic effect, and effect is suitable with positive controls.1-3 of the embodiment of the present invention
Group floral water antipruritic effect is rapid-action, and repellent antipruritic curative effect total effective rate is high, and significant effect is better than 1 group of comparative example and comparative example 2
Group, illustrates each component synergistic effect of the floral water of the invention containing Folium Artemisiae Argyi extract, has significant repellent antipruritic effect, its
In, the floral water repellent antipruritic effect that the embodiment of the present invention 2 is prepared is the most notable.
Test example three, resultant effect are investigated
Test period is in June, 2015-September, using opinion poll method, chooses 250 volunteers as object on probation, man
Female is fifty-fifty, age 18-45 Sui, is randomly divided into 5 groups by the principle of parallel control, every group of 50 people, respectively using the embodiment of the present invention
Floral water prepared by 1-3, comparative example 1-2.Respectively use 1 time sooner or later daily, smear the exposed skin such as leg and hand, even
It is continuous to use 2 weeks.Every using effect total score is 5 points.Result of the test is shown in Table 4.
4 resultant effect of table is investigated
| Group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 |
| Repelling effect | 4.8 | 4.3 | 4.5 | 3.1 | 3.8 |
| Repellent antipruritic effect | 4.6 | 4.8 | 4.4 | 3.7 | 3.2 |
| It is nonirritant | 4.8 | 4.3 | 4.6 | 3.5 | 3.8 |
| Smell | 4.3 | 4.4 | 4.5 | 3.8 | 4.0 |
Shown by floral water mosquito repellent of the above-mentioned results showed that present invention containing Folium Artemisiae Argyi extract and repellent antipruritic effect
Write, and floral water action temperature of the present invention with, skin irritation is small, using rear skin without dry sensation, is substantially better than using comfort
2 groups of 1 group of comparative example and comparative example, illustrate each component synergistic effect of the floral water of the invention containing Folium Artemisiae Argyi extract, good according to having
Mosquito repellent and repellent antipruritic effect, usage comfort improve.Comprehensive items using effect, the embodiment of the present invention 1 for the present invention most
Good embodiment.
The above-described embodiments merely illustrate the principles and effects of the present invention, not for the limitation present invention.It is any ripe
Know the personage of this technology all can carry out modifications and changes under the spirit and scope without prejudice to the present invention to above-described embodiment.Cause
This, those of ordinary skill in the art is complete without departing from disclosed spirit and institute under technological thought such as
Into all equivalent modifications or change, should by the present invention claim be covered.
Claims (5)
1. a kind of floral water containing Folium Artemisiae Argyi extract, it is characterised in that include the preparing raw material of following parts by weight：Folium artemisiae argyi is extracted
4-10 parts of thing, 10-20 parts of Negundo Chastetree Leaf, 8-15 parts of basyleave, 12-25 parts of purslane, 8-16 parts of dandelion, 7-15 parts of Asiatic plantain,
5-12 parts of sealwort, 2-8 parts of isopropyl palmitate, 60-70 parts of ethanol；The preparation of the floral water includes the following steps：
S1：Dry folium artemisiae argyi is taken, it is 2-6% sodium chloride solutions that the mass fraction that 6-10 times of its weight is measured is added after crushing, immersion
30-45min, the microwave treatment 2-5min under the power of 400-450W, steam distillation 1-3h, collect distillate, up to folium artemisiae argyi
Extract；
S2：Negundo Chastetree Leaf, basyleave, purslane, dandelion, Asiatic plantain and sealwort are taken, 8-12 times of coarse powder gross weight is added after crushing
The ethanol that volume fraction is 70-85% is measured, when immersion 3-6 is small, ultrasonic extraction 30-45 minutes at a temperature of 40-60 DEG C, supersonic frequency
Rate is 20-30 kHz, filtering；Filter residue adds 6-10 times of coarse powder gross weight and measures the ethanol that volume fraction is 70-85%, at 40-60 DEG C
At a temperature of ultrasonic extraction 30-45 minutes, supersonic frequency 20-30kHz, filtering；Merging filtrate, filtrate decompression are distilled to recover second
Alcohol, is concentrated into the concentrate that relative density at 60 DEG C is 1.02-1.06 g/mL；
S3：Concentrate 1200-1500 r/min are centrifuged into 8-15 min, it with molecular cut off is 10000-30000 to take supernatant
PS membrane carry out ultrafiltration, it is 1.20-1.30 g/mL that ultrafiltrate, which is concentrated under reduced pressure into relative density at 60 DEG C, up to traditional Chinese medicine extraction
Liquid；
S4：Chinese medicine extract described in Folium Artemisiae Argyi extract, S3 and isopropyl palmitate are added in ethanol, are uniformly mixed, to obtain the final product；
In the step S3, ultra-filtration conditions are inlet pressure 0.30-0.40MPa, liquid outlet 0.25-0.35MPa, feed temperature
35-40 DEG C, feed velocity 2.0-3.0 m/s.
2. the floral water containing Folium Artemisiae Argyi extract as claimed in claim 1, it is characterised in that include the preparation of following parts by weight
Raw material：8 parts of Folium Artemisiae Argyi extract, 18 parts of Negundo Chastetree Leaf, 15 parts of basyleave, 20 parts of purslane, 10 parts of dandelion, 12 parts of Asiatic plantain are yellow
10 parts of essence, 4 parts of isopropyl palmitate, 65 parts of ethanol.
3. the floral water containing Folium Artemisiae Argyi extract as claimed in claim 1, it is characterised in that include the preparation of following parts by weight
Raw material：6 parts of Folium Artemisiae Argyi extract, 12 parts of Negundo Chastetree Leaf, 12 parts of basyleave, 25 parts of purslane, 12 parts of dandelion, 15 parts of Asiatic plantain are yellow
8 parts of essence, 7 parts of isopropyl palmitate, 70 parts of ethanol.
4. the floral water containing Folium Artemisiae Argyi extract as claimed in claim 1, it is characterised in that include the preparation of following parts by weight
Raw material：5 parts of Folium Artemisiae Argyi extract, 10 parts of Negundo Chastetree Leaf, 10 parts of basyleave, 15 parts of purslane, 16 parts of dandelion, 10 parts of Asiatic plantain are yellow
12 parts of essence, 5 parts of isopropyl palmitate, 60 parts of ethanol.
5. the floral water containing Folium Artemisiae Argyi extract as described in claim 1-4 is any, it is characterised in that the volume of the ethanol
Fraction is 45%-60%.
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| CN201610162604.5A CN105708763B (en) | 2016-03-21 | 2016-03-21 | A kind of floral water containing Folium Artemisiae Argyi extract and preparation method thereof |
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| CN111643419B (en) * | 2020-07-14 | 2023-03-24 | 山东广玉源环保科技有限公司 | Mosquito-repelling and itching-relieving floral water and preparation method thereof |
| CN112451440A (en) * | 2020-12-08 | 2021-03-09 | 黄精钢 | Natural plant extracted perfume and its production process |
| CN115089646A (en) * | 2022-03-25 | 2022-09-23 | 翁源县生命好生物科技有限公司 | Externally-applied combined traditional Chinese medicine as well as preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1085784A (en) * | 1993-05-03 | 1994-04-27 | 张维文 | A kind of compound method of external Chinese patent medicine |
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| KR20110045440A (en) * | 2009-10-27 | 2011-05-04 | 박병채 | Mosquito repellent compositions |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1085784A (en) * | 1993-05-03 | 1994-04-27 | 张维文 | A kind of compound method of external Chinese patent medicine |
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