CN108245602A - It is a kind of to treat dermopathic external medicine composition - Google Patents
It is a kind of to treat dermopathic external medicine composition Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
Dermopathic external medicine composition is treated the invention discloses a kind of, is prepared by the raw material of following parts by weight through percolation or infusion method：50 200 parts of dragon's blood, 30 80 parts of Asian puccoon, 12 30 parts of kuh-seng, 12 30 parts of honeysuckle, 10 30 parts of Radix Glycyrrhizae；External medicine composition is condensed into liquid extract or is dried to powder, is uniformly mixed after then adding matrix, auxiliary material, traditional Chinese medicine for outer use can be made according to this field conventional method.The Chinese medicine composition and preparation of the present invention, with anti-inflammatory, sterilization, it is antipruritic, more wound, myogenic the effect of, can rapid recovery scytitis reaction, it is notable to curative effect of disease such as acne, furuncles, meanwhile skin lesion healing, recovery have very good effect caused by corresponding illness.
Description
Technical field
The present invention relates to a kind of treat dermopathic external medicine composition, and in particular to a kind of to treat furuncle, acne
External medicine composition belongs to traditional Chinese medicine for outer use technical field.
Background technology
When treating acne, furuncle when inflammation, infection, in western medicine field, it is mostly used antibiotics, steroids and resists true
Mushroom drug, side effect is larger, easy recurrence, and can form scar after curing.
And the traditional Chinese medical science is attributed to " inside accumulateing damp and hot, diseases caused by external factors ailment said due to cold or exposure heat evil " more to the generation of acne, furuncle, use is clearing heat and detoxicating, thin
The wet medicine treatment of wind-dryness can be described as suiting the remedy to the case, and be found in clinical practice for many years, although simple eliminating evil therapy can rise
To certain curative effect, but there is also three big shortcomings：
(1) though working soon, effect decreased significantly after a few days for treatment, and healing generally requires for a long time；
(2) person is not cured for intractable sufferer, especially prolonged illness, it is ineffective；
(3) patient's skin often has clear scar after curing, and disease hair is especially difficult to receive for the patient of face.
Applicant of the present invention attempt with based on righting, the therapeutic thoughts supplemented by eliminating evil develop the present invention, clinical practice
Show that the present invention is significant in efficacy to acne, furuncle, and have special effect to skin lesion, the scar recovery after sick disappear, the overwhelming majority suffers from
After person's (not being cured person including older before treatment) is treated with this side, acne, furuncle can cure rapidly, and skin returns to normal
State, most of patient more after without scar, this point is particularly important in the patient of face to disease hair.
Invention content
The technical problems to be solved by the invention are for the deficiencies in the prior art, and provide and a kind of treat skin
Disease external medicine composition, the Chinese medicine composition have anti-inflammatory, sterilization, it is antipruritic, more wound, myogenic the effect of, can be quick
Alleviate scytitis reaction, it is notable to curative effect of disease such as acne, furuncles, meanwhile, skin lesion healing, recovery caused by corresponding illness
There is very good effect.
To achieve these goals, the present invention adopts the following technical scheme that：
It is a kind of to treat dermopathic external medicine composition, it is prepared by the raw material of following mass parts through percolation or infusion method
It forms：50-200 parts of dragon's blood, 30-80 parts of Asian puccoon, 12-30 parts of kuh-seng, 12-30 parts of honeysuckle, 10-30 parts of Radix Glycyrrhizae.
In above-mentioned technical proposal, the raw material of following mass parts is preferably included：100 parts of dragon's blood, 40 parts of Asian puccoon, 20 parts of kuh-seng,
20 parts of honeysuckle, 12 parts of Radix Glycyrrhizae.
In above-mentioned technical proposal, the dermopathic external medicine composition of the treatment is prepared by percolation
, method includes the following steps：30-80 portions of Asian puccoons, 12-30 parts of kuh-sengs, 12-30 portions of honeysuckles, 10-30 portions of Radix Glycyrrhizaes are ground into altogether
Coarse powder is placed in percolator by coarse powder, by 12 times of amount (volumes of coarse powder：Quality) 95% (volume fraction) ethyl alcohol by percolator
Top is constantly added to the enterprising Mobile state of coarse powder and leaches extraction, and obtained leachate is liquid A；50-200 parts of dragon's blood are dissolved in
4 times of amount (volumes：Quality) 95% ethyl alcohol in, obtain liquid B；It stands after liquid A and liquid B are mixed and filters afterwards for 24 hours, will filter
5-10 times of liquid capacity-fixed to raw material gross mass after liquid evaporation measures (volume：Quality) to get the dermopathic external application Chinese medicine for the treatment of
Composition；
Preferably, described 12 times amounts refer to the volume of 95% ethyl alcohol：Quality=12 of coarse powder：1；Described 4 times
Amount refers to the volume of 95% ethyl alcohol：Quality=4 of dragon's blood：1；Described 5-10 times refers to the volume after constant volume：Raw material
Gross mass=5-10：1；
Preferably, the coarse powder, grain size 0.1-0.8cm；
Preferably, 95% ethyl alcohol of 12 times of amounts of coarse powder is constantly added to the enterprising Mobile state of coarse powder by the top of percolator
When leaching extraction, the addition of 95% ethyl alcohol is finished in 20-30h；
Preferably, the evaporation, temperature are no more than 65 DEG C.
In above-mentioned technical proposal, the dermopathic external medicine composition of the treatment is prepared by infusion method
, method includes the following steps：By 50-200 parts of dragon's blood, 30-80 portions of Asian puccoons, 12-30 parts of kuh-sengs, 12-30 parts of honeysuckles, 10-
30 portions of Radix Glycyrrhizaes are ground into coarse powder altogether, with 10 times of amount (volumes of coarse powder：Quality) 95% ethyl alcohol impregnate 4-5 days, daily stir for several times, mistake
Filter, (volume is measured by 5-10 times of filtrate constant volume to raw material gross mass：Quality) to get the dermopathic external application Chinese medicine for the treatment of
Composition；
Preferably, described 10 times amounts refer to the volume of 95% ethyl alcohol：Quality=10 of coarse powder：1；The 5-10
Times, refer to the volume after constant volume：Raw material gross mass=5-10：1；
Preferably, the coarse powder, grain size 0.1-0.8cm.
Dermopathic traditional Chinese medicine for outer use is treated the present invention also provides a kind of, is that above-mentioned is passed through into percolation or infusion method
Obtained external medicine composition is condensed into liquid extract or is dried to powder, is mixed after then adding matrix commonly used in the art
It is even, it is prepared into acceptable dosage form according to this field conventional method；
Preferably, the dosage form is any one in ointment, suppository, film, lotion or emulsion；
Preferably, the mass ratio of the matrix and external medicine composition is 1-20：1-10, preferably 5-10：1-6；
Preferably, the matrix is matrix commonly used in the art, such as albolene, lanolin etc..
In the present invention, dermopathic external medicine composition, the dermopathic traditional Chinese medicine for outer use for the treatment of are treated, can be used
It treats skin disease, particularly treats furuncle and acne.When treating furuncle, external medicine composition or external application are dipped with absorbent cotton
Chinese medicine preparation embrocates affected part, 2-3 times daily, and dosage is subject to being capable of uniform fold affected part；When treating acne, dipped with absorbent cotton
External medicine composition or traditional Chinese medicine for outer use embrocate affected part, 1-2 times daily, and dosage is subject to being capable of uniform fold affected part.
Using dragon's blood as monarch drug in a prescription in the present invention：Dragon's blood can promoting blood circulation to remove blood stasis, analgesic therapy hemostasis, expelling pus and promoting granulation.We mainly apply it
Righting effect of expelling pus and promoting granulation excites self-regeneration and the healing ability of skin, then passes through human autoimmune's function and life
Hair function resists disease, and help the self-regeneration of skin injury.
Using Asian puccoon, honeysuckle, kuh-seng as ministerial drug in the present invention：Asian puccoon can clearing heat and cooling blood, promoting blood circulation and detoxication, promoting eruption ecchymose removing, gold
Honeysuckle flower can clearing heat and detoxicating, wind-dispelling heat-dissipating, kuh-seng can heat-clearing and damp-drying drug, diuresis it is antipruritic, the benefits of eliminating evil is antipruritic, Neng Goutong are played in we
It crosses and removes the performance that patient's heat evil, damp evil, ailment said due to cold or exposure help dragon's blood effect, while play reduction patient sufferings jointly with dragon's blood and feel
Effect.
Using Radix Glycyrrhizae to make medicine in the present invention.Radix Glycyrrhizae can relieving spasm to stop pain, coordinating the drug actions of a prescription, played in we priming enter in, adjust
And the effect of pharmacological property, above-mentioned monarch drug in a prescription, ministerial drug can be helped to play drug effect, and reduce medicine irritation.
From the point of view of current clinical medicine and pharmacological point, dragon's blood on the one hand being capable of antagonism inflammation, detumescence, reduction purulence point
Secretion accelerates Wound healing, on the other hand also has different degrees of inhibiting effect to epidermis pathomycete, bacterium；Asian puccoon has
Anti-inflammatory, antimycotic, Scavenger of ROS function；Honeysuckle has broad-spectrum antiseptic, antiviral, antipyretic, anti-inflammatory effect；Kuh-seng has
Antiviral, antiallergic action and anti-inflammatory efficacy；Radix Glycyrrhizae also has anti-oxidant, antibacterial and anti-inflammatory activity.Show that we study the science from pharmacology
By and practice in also obtained fabulous support.
The Chinese medicine composition and Chinese medicine preparation of the present invention, all medicine cooperations can effectively inhibit inflammatory reaction, sterilize, is antipruritic, soon
Speed is cured outside disease, and skin lesion healing can more be promoted to restore, make lesions of patients position as excellent as before, and have no toxic side effect.
Specific embodiment
The specific embodiment of technical solution of the present invention is described in detail below, but the present invention is not limited in being described below
Hold：
Embodiment 1：
It is a kind of to treat dermopathic external medicine composition, it is prepared by following methods：
Dragon's blood 100g, Asian puccoon 40g, kuh-seng 20g, honeysuckle 20g, Radix Glycyrrhizae 12g are taken, being ground into coarse powder altogether, (coarse powder grain size is
0.1-0.8cm crosses No. two sieves, No. two mesh size 0.85cm), it is impregnated 5 days with 95% ethyl alcohol of 2000ml after mixing, stirs 3 daily
It is secondary, it filters, is filtered after dregs pressing, merging filtrate, filtrate is settled to 2000ml to get dermopathic external application Chinese medicine group is treated
Close object.
Embodiment 2：
It is a kind of to treat dermopathic external medicine composition, it is prepared by following methods：
Take 60g Asian puccoons, 28g kuh-sengs, 28g honeysuckles, 20g Radix Glycyrrhizaes, be ground into altogether coarse powder (coarse powder grain size be 0.1-0.8cm, mistake
No. two sieves, No. two mesh size 0.85cm), coarse powder is placed in percolator, by 95% ethyl alcohol of 1600ml by the top of percolator
The continuous enterprising Mobile state of coarse powder that is added to leaches extraction, and the percolate rate of outflow is 1-3ml/min, and obtained leachate is liquid
Body A；200g dragon's blood is dissolved in 95% ethyl alcohol of 800ml, obtains liquid B；Mistake afterwards is stood for 24 hours after liquid A and liquid B are mixed
Filter, the liquid obtained after filtrate is concentrated under reduced pressure at 50 DEG C are dermopathic to get treating with 95% ethyl alcohol constant volume to 1800ml
External medicine composition.
Embodiment 3：
It is a kind of to treat dermopathic external medicine composition, it is prepared by following methods：
Dragon's blood 80g, Asian puccoon 50g, kuh-seng 20g, honeysuckle 20g, Radix Glycyrrhizae 15g are taken, being ground into coarse powder altogether, (coarse powder grain size is 0.1-
0.8cm crosses No. two sieves, No. two mesh size 0.85cm), it is impregnated 5 days with 95% ethyl alcohol of 2000ml after mixing, daily stirring 3 times,
Filtrate is settled to 2000ml to get dermopathic external medicine composition is treated by filtering.
Embodiment 4：
It is a kind of to treat dermopathic traditional Chinese medicine for outer use, it is by the external medicine composition in embodiment 2, is concentrated under reduced pressure into
Density is the liquid extract of 1.10-1.30, and per 100g liquid extracts addition 800g albolene, 100g lanolin, heating mixing is made
Ointment.
Clinical efficacy one：The dermopathic clinical sight of external medicine composition treatment furuncle 198 for the treatment of that embodiment 1 obtains
It examines：
1st, patient is grouped
All patients are diagnosed as suffering from furuncle according to Chinese medical discrimination method, altogether both from hospital outpatient or inpatient
198, wherein male patient 133, age are 16-49 Sui, female patient 65, age 17-42 Sui.
2nd, therapy
The external medicine composition dipped in embodiment 1 with absorbent cotton embrocates affected part, 2-3 times daily, each 0.5-3ml,
Dosage be subject to can uniform fold affected part, 5-15 days altogether.
3rd, curative effect determinate standard
It cures：Disease obtains effective, thorough treatment, and corresponding symptom completely disappears；
It is effective：Disease is effectively treated, and symptom is substantially reduced, but is not completely disappeared；
In vain：The drug is to disease almost without therapeutic effect, and disease symptoms are without alleviation；
Recurrence：Refer to illness has rebound phenomenon after healing in 6-12 months.
4th, result
As shown in table 1：
Table 1：The external medicine composition that embodiment 1 obtains treats the effect of furuncle observation table
As shown in Table 1, during the external medicine composition treatment furuncle that the embodiment of the present invention 1 obtains, high efficiency reaches
98.46%, and without recurrence；Patient after healing, cutaneous lesion is as excellent as before, no scar.
Clinical efficacy two：The dermopathic clinical sight of external medicine composition treatment acne 131 for the treatment of that embodiment 1 obtains
It examines：
1st, patient is grouped
All patients are diagnosed as suffering from acne according to Chinese medical discrimination method, altogether both from hospital outpatient or inpatient
131, wherein male patient 59, age are 15-28 Sui, female patient 72, age 14-23 Sui.
2nd, therapy
The external medicine composition dipped in embodiment 1 with absorbent cotton embrocates affected part, 1-2 times daily, each 0.5-3ml,
Dosage be subject to can uniform fold affected part, 5-40 days altogether.
3rd, curative effect determinate standard
It cures：Disease obtains effective, thorough treatment, and corresponding symptom completely disappears；
It is effective：Disease is effectively treated, and symptom is substantially reduced, but is not completely disappeared；
In vain：The drug is to disease almost without therapeutic effect, and disease symptoms are without alleviation；
Recurrence：Refer to illness has rebound phenomenon after healing in 6-12 months.
4th, result
As shown in table 2：
Table 2：The external medicine composition that embodiment 1 obtains treats the effect of acne observation table
As shown in Table 2, during the external medicine composition treatment acne that the embodiment of the present invention 1 obtains, high efficiency reaches
100%；Patient after healing, cutaneous lesion is as excellent as before, no scar.
Examples detailed above is technical concept and technical characterstic to illustrate the invention, can not limit the present invention's with this
Protection domain.The equivalent transformation or modification that all essence according to the present invention is done, should all cover in protection scope of the present invention
Within.
Claims (10)
1. a kind of treat dermopathic external medicine composition, which is characterized in that by the raw material of following mass parts through percolation or
What infusion method was prepared：50-200 parts of dragon's blood, 30-80 parts of Asian puccoon, 12-30 parts of kuh-seng, 12-30 parts of honeysuckle, Radix Glycyrrhizae 10-30
Part.
2. external medicine composition according to claim 1, which is characterized in that include the raw material of following mass parts：Dragon's blood
100 parts, 40 parts of Asian puccoon, 20 parts of kuh-seng, 20 parts of honeysuckle, 12 parts of Radix Glycyrrhizae.
3. external medicine composition according to claim 1, which is characterized in that the external medicine composition is to pass through
What percolation was prepared, include the following steps：By 30-80 portions of Asian puccoons, 12-30 parts of kuh-sengs, 12-30 portions of honeysuckles, 10-30 parts
Radix Glycyrrhizae is ground into coarse powder altogether, and coarse powder is placed in percolator, and 95% ethyl alcohol of 12 times of amounts of coarse powder is continuous by the top of percolator
It is added to the enterprising Mobile state of coarse powder and leaches extraction, obtained leachate is liquid A；By 50-200 parts of dragon's blood be dissolved in 4 times amount
In 95% ethyl alcohol, liquid B is obtained；It stands after liquid A and liquid B are mixed and filters afterwards for 24 hours, the liquid capacity-fixed after filtrate is evaporated
To 5-10 times of raw material gross mass to get treating dermopathic external medicine composition.
4. external medicine composition according to claim 3, which is characterized in that 12 times of amounts refer to 95% second
The volume of alcohol：Quality=12 of coarse powder：1；4 times of amounts refer to the volume of 95% ethyl alcohol：Quality=4 of dragon's blood：1；Institute
5-10 times stated refers to the volume after constant volume：Raw material gross mass=5-10：1.
5. external medicine composition according to claim 3, which is characterized in that the coarse powder, grain size 0.1-
0.8cm；The evaporation, temperature are no more than 65 DEG C；95% ethyl alcohol of 12 times of amounts of coarse powder is constantly added by the top of percolator
When being added to the enterprising Mobile state of coarse powder and leaching extraction, the addition of 95% ethyl alcohol is finished in 20-30h.
6. external medicine composition according to claim 1, which is characterized in that the external medicine composition is to pass through
What infusion method was prepared, include the following steps：By 50-200 parts of dragon's blood, 30-80 portions of Asian puccoons, 12-30 parts of kuh-sengs, 12-30 parts
Honeysuckle, 10-30 portions of Radix Glycyrrhizaes are ground into coarse powder altogether, are impregnated 4-5 days with 95% ethyl alcohol of 10 times of amounts of coarse powder, stir daily for several times, mistake
Filter, by 5-10 times of filtrate constant volume to raw material gross mass to get the dermopathic external medicine composition for the treatment of.
7. external medicine composition according to claim 6, which is characterized in that the coarse powder, grain size 0.1-
0.8cm；10 times of amounts refer to the volume of 95% ethyl alcohol：Quality=10 of coarse powder：1；Described 5-10 times, refers to
Volume after constant volume：Raw material gross mass=5-10：1.
8. a kind of treat dermopathic traditional Chinese medicine for outer use, it is characterised in that：It is by the external application Chinese medicine group in claim 3 or 5
It closes object to be condensed into liquid extract or be dried to powder, be uniformly mixed after then adding matrix commonly used in the art, according to this field routine
The acceptable dosage form that method is prepared into.
9. traditional Chinese medicine for outer use according to claim 8, it is characterised in that：The dosage form is ointment, suppository, film
Any one in agent, lotion or emulsion.
10. traditional Chinese medicine for outer use according to claim 8, it is characterised in that：The matrix and external medicine composition
Mass ratio be 1-20：1-10.
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| CN109589372A (en) * | 2019-01-02 | 2019-04-09 | 江西乾坤堂健康科技有限公司 | A kind of compound book on Chinese herbal medicine antibacterial liquid and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109589372A (en) * | 2019-01-02 | 2019-04-09 | 江西乾坤堂健康科技有限公司 | A kind of compound book on Chinese herbal medicine antibacterial liquid and preparation method thereof |
| CN112316012A (en) * | 2020-11-19 | 2021-02-05 | 陕西康乐实业有限公司 | Moisturizing antibacterial gel and preparation method thereof |
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