CN106237203A - Treat psoriatic ointment - Google Patents

Treat psoriatic ointment Download PDF

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Publication number
CN106237203A
CN106237203A CN201610919959.4A CN201610919959A CN106237203A CN 106237203 A CN106237203 A CN 106237203A CN 201610919959 A CN201610919959 A CN 201610919959A CN 106237203 A CN106237203 A CN 106237203A
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ointment
parts
radix
folium artemisiae
artemisiae argyi
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CN201610919959.4A
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阎靖涛
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Jilin Sheng'ao Biological Technology Co Ltd
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Jilin Sheng'ao Biological Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234Cnidium (snowparsley)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/756Phellodendron, e.g. corktree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/904Stemonaceae (Stemona family), e.g. croomia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to one and treat psoriatic ointment, belong to technical field of Chinese medicines.This ointment is made up of the crude drug of following weight portion: Radix Sophorae Flavescentis 10 50 parts, Cortex Phellodendri 10 50 parts, the Radix Stemonae 10 50 parts, Fructus Cnidii 10 50 parts, favus skin 10 50 parts, Folium Artemisiae Argyi extract 1 part, Radix Astragali extractive solution 1 part, moisturizing substrate 100 300 parts;Described ointment is prepared by following method: by above-mentioned weight portion weighting raw materials, dry, pulverize after first Radix Sophorae Flavescentis, Cortex Phellodendri, the Radix Stemonae, Fructus Cnidii and favus skin being concocted, sieve to obtain crude drug powder, this crude drug powder and Folium Artemisiae Argyi extract, Radix Astragali extractive solution are extracted to obtain extracting solution again, then extracting solution and moisturizing substrate are blended makes described ointment.The psoriatic ointment for the treatment of that the present invention provides has heat-clearing and toxic substances removing, invigorate blood circulation and moisturize, dispelling wind for relieving itching effect, notable to the therapeutic effect of psoriatic, particularly pustule-type psoriatic effect highly significant, cure rate can reach 85%, and toxic and side effects is little, and short treating period, medical expense are low, control the features such as difficulty in relapse after healing.

Description

Treat psoriatic ointment
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to one and treat psoriatic ointment.
Background technology
Psoriasis is commonly called as psoriasis, is that a kind of chronic inflammatory skin is sick, and the course of disease is longer, has easy tendency of recurrence, some diseases Example almost cannot be cured all one's life.This disease is fallen ill based on person between twenty and fifty, affects bigger on the healthy of patient and mental status.Clinical table Now based on erythema, squama, whole body all can be fallen ill, and stretches side with scalp, extremity relatively conventional, increases the weight of the most in the winter time.Primary disease is current There is no specific short, but not incurable disease.Suitable symptomatic treatment can control symptom.Owing to primary disease is a kind of chronic recurrence Property disease, many patients need long-term medical, and various therapy has certain untoward reaction.Though western medicine therapy has necessarily at present Short run effect, but exacerbation after drug withdrawal, it is impossible to thoroughly effect a radical cure.And Chinese traditional treatment psoriasis method is flexible and changeable, and Determined curative effect, has the prolongation catabasis, the advantage that toxic and side effects is little.Therefore can develop and a kind of new may be used for treatment silver The Chinese medicine of bits disease just seems most important.
Summary of the invention
It is an object of the invention to provide the psoriatic ointment for the treatment of that a kind of therapeutic effect is notable, toxic and side effects is little.
To achieve these goals, technical scheme is specific as follows:
The psoriatic ointment for the treatment of that the present invention provides, this ointment is made up of the crude drug of following weight portion:
Radix Sophorae Flavescentis 10-50 part, Cortex Phellodendri 10-50 part, Radix Stemonae 10-50 part, Fructus Cnidii 10-50 part, favus skin 10-50 part, Folium Artemisiae Argyi Extract 1 part, Radix Astragali extractive solution 1 part, moisturizing substrate 100-300 part;
Described ointment is prepared by following method: by above-mentioned weight portion weighting raw materials, first by Radix Sophorae Flavescentis, Cortex Phellodendri, the Radix Stemonae, Serpentis Machine tool and favus skin dry after concocting, pulverize, sieve to obtain crude drug powder, then by this crude drug powder and Folium Artemisiae Argyi extract, Radix Astragali extractive solution Extract to obtain extracting solution, then extracting solution and moisturizing substrate are blended make described ointment.
In technique scheme, described ointment is made up of the crude drug of following weight parts: Radix Sophorae Flavescentis 30 parts, Cortex Phellodendri 30 Part, the Radix Stemonae 30 parts, Fructus Cnidii 30 parts, favus skin 30 parts, Folium Artemisiae Argyi extract 1 part, Radix Astragali extractive solution 1 part, moisturizing substrate 200 parts.
In technique scheme, described moisturizing substrate is vaseline.
In technique scheme, described Folium Artemisiae Argyi extract is to use following method to prepare:
With dry Folium Artemisiae Argyi medical material as raw material, add deionized water, 96 DEG C of water-bath backflow 90min after alcohol degreasing, obtain Chinese mugwort Leaf infusion, is repeated 2 times, and is merged by the infusions of 3 times, filters, is concentrated to dryness with decompression Rotary Evaporators, obtains Folium Artemisiae Argyi and extracts Thing, the extraction ratio of Folium Artemisiae Argyi is 20%, i.e. the ratio of medical material and extract is 5:1.
In technique scheme, described Radix Astragali extractive solution is to use following method to prepare:
With 50g Radix Astragali powder as raw material, add water 500mL, and heated and boiled is also stirred continuously, and keeps 30min, adds anhydrous Ethanol 200mL, stirring and evenly mixing, room temperature stands 2h, and gauze and filter paper filtering, rotary evaporator are concentrated into 150mL, obtains 150mL yellow Stilbene extracting solution, the concentration of gained Radix Astragali extractive solution effective ingredient is 0.33g/mL.
The usage treating psoriatic ointment that the present invention provides: after being cleaned up in the affected part of psoriatic, passes through Medicine antiperspirant steams, and the ointment of the present invention is smeared affected part, then carries out package;Coordinate phototherapy 20 minutes twice daily;Wherein said Medicine antiperspirant steam in medicine be Folium Artemisiae Argyi and Cortex Pseudolaricis.
The invention has the beneficial effects as follows:
The psoriatic ointment for the treatment of that the present invention provides is to be produced acquirement by each taste drug matching, and raw materials used medicine is few, adopts Taking first process of preparing Chinese medicine part material medicine, then extract to obtain extracting solution with remaining crude drug, final and moisturizing substrate blends and makes described medicine The technique of cream is prepared from.Gained ointment has heat-clearing and toxic substances removing, invigorates blood circulation and moisturizes, dispelling wind for relieving itching effect, controls psoriatic Therapeutic effect is notable, particularly pustule-type psoriatic effect highly significant, and toxic and side effects is little.
The psoriatic ointment for the treatment of that the present invention provides, cure rate can reach 86%, and short treating period, medical expense are low, healing After be difficult to the features such as recurrence.
Detailed description of the invention
In following embodiment, Folium Artemisiae Argyi extract used, Radix Astragali extractive solution use preceding method to prepare, and moisturizing substrate is all Intellectual circle.
Embodiment 1
Weighting raw materials, Radix Sophorae Flavescentis 10g, Cortex Phellodendri 10g, Radix Stemonae 10g, Fructus Cnidii 10g, favus skin 10g, Folium Artemisiae Argyi extract 1g, Radix Astragali extractive solution 1g, vaseline 100g;Dry after Radix Sophorae Flavescentis, Cortex Phellodendri, the Radix Stemonae, Fructus Cnidii and favus skin are concocted, pulverize, sieve Crude drug powder, extracts to obtain extracting solution by this crude drug powder and Folium Artemisiae Argyi extract, Radix Astragali extractive solution, then is blended with vaseline by extracting solution Make described ointment.
Embodiment 2
Weighting raw materials, Radix Sophorae Flavescentis 50g, Cortex Phellodendri 50g, Radix Stemonae 50g, Fructus Cnidii 50g, favus skin 50g, Folium Artemisiae Argyi extract 1g, Radix Astragali extractive solution 1g, vaseline 300g;Dry after Radix Sophorae Flavescentis, Cortex Phellodendri, the Radix Stemonae, Fructus Cnidii and favus skin are concocted, pulverize, sieve Crude drug powder, extracts to obtain extracting solution by this crude drug powder and Folium Artemisiae Argyi extract, Radix Astragali extractive solution, then is blended with vaseline by extracting solution Make described ointment.
Embodiment 3
Weighting raw materials, Radix Sophorae Flavescentis 30g, Cortex Phellodendri 30g, Radix Stemonae 30g, Fructus Cnidii 30g, favus skin 30g, Folium Artemisiae Argyi extract 1g, Radix Astragali extractive solution 1g, vaseline 200g;Dry after Radix Sophorae Flavescentis, Cortex Phellodendri, the Radix Stemonae, Fructus Cnidii and favus skin are concocted, pulverize, sieve Crude drug powder, extracts to obtain extracting solution by this crude drug powder and Folium Artemisiae Argyi extract, Radix Astragali extractive solution, then is blended with vaseline by extracting solution Make described ointment.
The therapeutic effect of ointment that the present invention provide is expanded on further below by way of clinical observation on the therapeutic effect experiment.
1, physical data
Collect light moderate psoriatic 140 example, patient is assigned randomly to experimental group (composite treatment group) and matched group (placebo group), often group patient 70 example.
2, diagnostic criteria
Erythra development is relatively rapid, and skin rises red, and newborn erythra constantly occurs, squama is more, and epidermis is easily peeled, and has after stripping Sieve-like petechia, substrate infiltration is deep, and pruritis is more apparent, often accompanies dry mouth and tougue, constipation, susceptible to lose temper due to restlessness, oliguria with reddish urine Deng General Symptoms.
3, Therapeutic Method
Experimental group 70 example, after dipping every day, the external embodiment of the present invention 3 preparation ointment and carry out package, twice daily Coordinate phototherapy 20 minutes;Matched group 70 example, external vaseline carry out package after common water-bath, twice daily, coordinate phototherapy 20 Minute;8 weeks courses for the treatment of, further consultation is once every two weeks, observes and record index.
4, efficacy assessment standard
Cure: skin heals completely, and pruritus is wholly absent, and skin becomes smooth flexible, and other corresponding symptoms disappear the most Lose, recover normal person's life, the recurrence after healing can be avoided.
Effective: the erythema of skin, squama and infiltration degree are obviously improved, skin lesion area reduces, and other corresponding symptom starts Take a turn for the better.
Invalid: all symptoms are all without taking a turn for the better.
5, therapeutic effect:
After medication 8 weeks, in experimental group 70 example patient, curing 60 examples, effective 10 examples, invalid 0 example, cure rate reaches 86%, Total effective rate 100%.Matched group patients symptomatic be not improved.
The ointment that embodiment 1 and 2 prepares can obtain above-mentioned therapeutic effect too, states the most one by one.
Obviously, above-described embodiment is only for clearly demonstrating example, and not restriction to embodiment.Right For those of ordinary skill in the field, can also make on the basis of the above description other multi-form change or Variation.Here without also cannot all of embodiment be given exhaustive.And the obvious change thus extended out or Change among still in the protection domain of the invention.

Claims (5)

1. treat psoriatic ointment for one kind, it is characterised in that this ointment is made up of the crude drug of following weight portion:
Radix Sophorae Flavescentis 10-50 part, Cortex Phellodendri 10-50 part, Radix Stemonae 10-50 part, Fructus Cnidii 10-50 part, favus skin 10-50 part, Folium Artemisiae Argyi is extracted Thing 1 part, Radix Astragali extractive solution 1 part, moisturizing substrate 100-300 part;
Described ointment is prepared by following method: by above-mentioned weight portion weighting raw materials, first by Radix Sophorae Flavescentis, Cortex Phellodendri, the Radix Stemonae, Fructus Cnidii Dry, pulverize after concocting with favus skin, sieve to obtain crude drug powder, then by this crude drug powder and Folium Artemisiae Argyi extract, Radix Astragali extractive solution extraction Extracting solution, then extracting solution and moisturizing substrate blended make described ointment.
The psoriatic ointment for the treatment of the most according to claim 1, it is characterised in that described ointment is by following weight parts Crude drug forms: Radix Sophorae Flavescentis 30 parts, Cortex Phellodendri 30 parts, the Radix Stemonae 30 parts, Fructus Cnidii 30 parts, favus skin 30 parts, Folium Artemisiae Argyi extract 1 part, yellow Stilbene extracting solution 1 part, moisturizing substrate 200 parts.
The psoriatic ointment for the treatment of the most according to claim 1 and 2, it is characterised in that described moisturizing substrate is vaseline.
The psoriatic ointment for the treatment of the most according to claim 1 and 2, it is characterised in that described Folium Artemisiae Argyi extract is to use Following method prepares:
With dry Folium Artemisiae Argyi medical material as raw material, add deionized water, 96 DEG C of water-bath backflow 90min after alcohol degreasing, obtain Folium Artemisiae Argyi water Immersion, is repeated 2 times, and is merged by the infusions of 3 times, filters, is concentrated to dryness with decompression Rotary Evaporators, obtains Folium Artemisiae Argyi extract.
The psoriatic ointment for the treatment of the most according to claim 1 and 2, it is characterised in that described Radix Astragali extractive solution is to use Following method prepares:
With 50g Radix Astragali powder as raw material, add water 500mL, and heated and boiled is also stirred continuously, and keeps 30min, adds dehydrated alcohol 200mL, stirring and evenly mixing, room temperature stands 2h, and gauze and filter paper filtering, rotary evaporator are concentrated into 150mL, obtain the 150mL Radix Astragali and carry Taking liquid, the concentration of gained Radix Astragali extractive solution effective ingredient is 0.33g/mL.
CN201610919959.4A 2016-10-21 2016-10-21 Treat psoriatic ointment Pending CN106237203A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107456510A (en) * 2017-07-11 2017-12-12 于均峰 A kind of ointment of the treatment psoriasis based on asafoetide root extract composition
CN111514240A (en) * 2020-04-22 2020-08-11 王亚军 Method for treating psoriasis
CN111973712A (en) * 2020-09-16 2020-11-24 北京同春堂中医医院(普通合伙) Traditional Chinese medicine bath composition for treating psoriasis, preparation method and application thereof
CN114272310A (en) * 2022-01-04 2022-04-05 淄博市妇幼保健院 Preparation method and device of medicine for treating psoriasis and external ointment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1413627A (en) * 2002-05-04 2003-04-30 付研彪 Medicine for treating dematosis
CN101229266A (en) * 2008-01-25 2008-07-30 贾进善 Medicine for curing psoriasis
CN102614440A (en) * 2012-04-27 2012-08-01 伊彩虹 Multi-herb antibacterial liquid

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1413627A (en) * 2002-05-04 2003-04-30 付研彪 Medicine for treating dematosis
CN101229266A (en) * 2008-01-25 2008-07-30 贾进善 Medicine for curing psoriasis
CN102614440A (en) * 2012-04-27 2012-08-01 伊彩虹 Multi-herb antibacterial liquid

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107456510A (en) * 2017-07-11 2017-12-12 于均峰 A kind of ointment of the treatment psoriasis based on asafoetide root extract composition
CN111514240A (en) * 2020-04-22 2020-08-11 王亚军 Method for treating psoriasis
CN111973712A (en) * 2020-09-16 2020-11-24 北京同春堂中医医院(普通合伙) Traditional Chinese medicine bath composition for treating psoriasis, preparation method and application thereof
CN114272310A (en) * 2022-01-04 2022-04-05 淄博市妇幼保健院 Preparation method and device of medicine for treating psoriasis and external ointment

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Application publication date: 20161221