CN107456510A - A kind of ointment of the treatment psoriasis based on asafoetide root extract composition - Google Patents
A kind of ointment of the treatment psoriasis based on asafoetide root extract composition Download PDFInfo
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- CN107456510A CN107456510A CN201710559782.6A CN201710559782A CN107456510A CN 107456510 A CN107456510 A CN 107456510A CN 201710559782 A CN201710559782 A CN 201710559782A CN 107456510 A CN107456510 A CN 107456510A
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- asafoetide
- root extract
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- ointment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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Abstract
The present invention provides a kind of ointment of the treatment psoriasis based on asafoetide root extract composition and is widely used in curing psoriasis technical field.The ointment is made up of the bulk drug of following parts by weight：50 150 parts of asafoetide root extract solution, 10 20 parts of golden cypress, 10 20 parts of safflower, 20 30 parts of frankincense, 50 100 parts of moisturizing substrate, the acquisition of wherein asafoetide root extract solution comprises the following steps：Choose high-quality asafoetide rhizome；Asafoetide rhizome is shredded and squeezes juice；Evaporation purification obtains asafoetide root extract solution.The asafoetide root extract solution of the present invention has good result, while asafoetide root extract solution acquisition methods are simple, low manufacture cost, are easy to promote the use of rich in sesquiterpenoids Coumarins, sesquiterpenoids and sulfur-containing compound etc. to treatment psoriasis.
Description
Technical field
The invention belongs to curing psoriasis technical field, more particularly to a kind for the treatment of silver based on asafoetide root extract composition
Consider the ointment of disease to be worth doing.
Background technology
Asafoetide is a kind of unique medicinal material in Xinjiang.Perennial once result draft, asafoetide are divided to two kinds of Xinjiang and circle stem asafoetide,
Belong to Umbelliferae, herbaceos perennial.Ferula sinkiangensis is high 50-100 centimetres, and complete stool drapes over one's shoulders white fluff, and root fertilizer is big, cylinder or
Spindle, branch sometimes, epidermis atropurpureus, there is foul smell, open yellow little Hua.Circle stem asafoetide is compared with it, and plant will double, stem
Uprightly.There was only Xinjiang growth in China.Asafoetide acrid flavour, temperature, there are qi-regulating detumescence, the effect of disappearing tired, eliminating the phlegm and excitor nerve of invigorating blood circulation.Dimension
I your its also useful expelling parasite of doctor, treat leucoderma and conventional method.It is distributed in Central Asia and Iran and Afghanistan.It is but existing
Utilization in technology to asafoetide concentrates on the extraction of asafoetide juice, the often abandoned of asafoetide root.
Psoriasis is commonly called as psoriasis, is a kind of chronic inflammatory skin, and the course of disease is longer, there is easy tendency of recurrence, some diseases
Example almost cannot be cured all one's life.The disease is fallen ill based on person between twenty and fifty, and the health and mental status of patient are had a great influence.Clinical table
Now based on erythema, the scales of skin that peel off, whole body can fall ill, and it is relatively conventional to stretch side with scalp, four limbs, aggravates in the winter time more.This disease is current
It there is no specific short, but not incurable disease.Appropriate symptomatic treatment can control symptom.Because this disease is a kind of chronic recurrence
Property disease, many patients need long-term medical, and various therapies have certain adverse reaction.Though western medicine therapy has necessarily at present
Short run effect, but exacerbation after drug withdrawal, it is impossible to thoroughly radical cure.And Chinese traditional treatment psoriasis method is flexible and changeable, and
It is curative for effect, have and extend the paracmasis, the small advantage of toxic side effect.The sesquiterpenoids Coumarins that is rich in asafoetide root, sesquialter
Terpene and sulfur-containing compound etc. have good result to treatment psoriasis.But it is existing treatment psoriasis ointment also there is
Therapeutic effect is poor, and manufacturing cost is high, the problem of complex manufacturing technology.
Therefore, invent a kind of ointment of the treatment psoriasis based on asafoetide root extract composition and seem very necessary.
The content of the invention
In order to solve the above-mentioned technical problem, the present invention provides a kind for the treatment of psoriasis based on asafoetide root extract composition
Ointment, poor to solve the medicinal ointment therapy effect of existing treatment psoriasis, manufacturing cost is high, the problem of complex manufacturing technology.One
The ointment for the treatment of psoriasis of the kind based on asafoetide root extract composition, the ointment are made up of the bulk drug of following parts by weight：
Asafoetide root extract solution 50-150 parts, golden cypress 10-20 parts, safflower 10-20 parts, frankincense 20-30 parts, moisturizing substrate
50-100 parts；
The ointment is made by following methods：Bulk drug is weighed by above-mentioned parts by weight, first by golden cypress, safflower and frankincense
Crude drug powder is dried, crushed, sieving and to obtain after processing, then extract solution is obtained by extraction in the crude drug powder and asafoetide root extract solution, then will be carried
Take liquid to be blended with moisturizing substrate and the ointment is made.
Preferably, the ointment of the treatment psoriasis based on asafoetide root extract composition is specifically extracted using asafoetide root
100 parts of liquid, 15 parts of golden cypress, 15 parts of safflower, 25 parts of frankincense, 80 parts of moisturizing substrate.
Preferably, the acquisition of described asafoetide root extract solution uses following steps：
Step 1：Choose high-quality asafoetide rhizome；
Step 2：Asafoetide rhizome is shredded and squeezes juice；
Step 3：Evaporation purification obtains asafoetide root extract solution.
Further, in step 1, described high-quality asafoetide rhizome refers to that the rhizome of Ferula sinkiangensis or Ferula fukanensis K.M.Shen is mitogenetic
Area or elongation zone.
Further, in step 2, asafoetide rhizome is cut into 2mm to 5mm segment and utilizes Chinese medicine slag squeezer pressure
Squeeze 20 to 30 minutes and obtain asafoetide root extract solution first product.
Further, in step 3, asafoetide root extract solution first product is inserted into decompression Rotary Evaporators and evaporated 30 to 50 minutes
Obtain asafoetide root extract solution.
Preferably, described moisturizing substrate is vaseline.
Compared with prior art, the present invention has the advantages that：Due to the present invention based on asafoetide root extract into
The ointment for the treatment psoriasis divided is widely used in curing psoriasis technical field.Meanwhile beneficial effects of the present invention are：This hair
Bright asafoetide root extract solution has rich in sesquiterpenoids Coumarins, sesquiterpenoids and sulfur-containing compound etc. to treatment psoriasis
Good result, while asafoetide root extract solution acquisition methods are simple, low manufacture cost, are easy to promote the use of.
Brief description of the drawings
Fig. 1 is the acquisition flow chart of the asafoetide root extract solution of the present invention.
Embodiment
Embodiment 1：
The animal model of psoriasiform dermatitis is prepared using imiquimod cream, experimental animal selection female BAl BIc/c is small
Mouse, 18-20g, purchased from Xinjiang Medicine University's animal experimental center, SPF ranks, (the bright glad medicine company in Sichuan is limited for imiquimod cream
Responsible company, 5%), desonide cream (Sichuan Hua Bang pharmaceutical Co. Ltds), asafoetide root extract external preparation (Xinjiang medical courses in general
The external preparation of various concentrations is made in the affiliated hospital Drug Manufacturing Room of university the 5th).
In experimentation according to according to PASI standards of grading carry out evaluate each group experimental animal back skin lesion appraisal results be shown in Table
Shown in 1, experimental group smearing gives imiquimod cream 2-3d back part skins and starts Mild edema, pachyderma occur；3-4 days
There is slight incrustation and the scales of skin that peel off in tested skin afterwards, and it is slower that thickening phenomenon occurs, over time, experimental mice skin damage
Hinder getting worse, pachyderma is obvious, and hair is irregular, or even a small number of patch shape scales of skin that peel offs occurs, at the 7th day, with normal control
Group mouse is compared, and model group mice skin erythema phenomenon is obvious, and skin substantially thickens, rough surface, and hair is disheveled.Treatment
Asafoetide root group mouse skin lesion erythema color compared with same period model group of group and various concentrations is shallow, and the scales of skin that peel off is rare, and skin is more smooth, increases
Thick phenomenon is lighter, and skin lesion symptom improves significantly (Fig. 1), and indices PASI scorings are below same period model group mouse (table
1).Each group skin lesion PASI scoring comparing differences are statistically significant, P<0.05.
Each experimental group PASI scorings of table 1BALB/c mouse psoriasis models
Note：★Compared with Normal group, P<0.05
Embodiment 2：
The patients with psoriasis vulgaris 16 that selection meets the Dermatology Outpatient Department of psoriasis diagnostic criteria and ward is in hospital, warp
Cross Ethics Committee of the court approval and patient sign informed consent form collection Case treatment before and treatment after affected part skin lesion shadow
As learning data.Therapeutic scheme：Psoriatic is randomly divided into desonide cream treatment group and asafoetide root cream for treating group (by new
Asafoetide root medicinal external emulsifiable paste is made in the affiliated hospital Drug Manufacturing Room of boundary medical university the 5th), basic medication each group is given drip-feed and answered
Square glycyrrhizin injection liquid 60ml, once a day, treat 10 days, (desonide cream is weak to desonide treatment group desonide cream
Imitate hormone medicine), twice a day, asafoetide root cream for treating group external application asafoetide root emulsifiable paste, twice a day, two groups are treated 10, and two
Group crowd is after different therapeutic schemes are treated 10, and typical skin lesion is relieved, and the scales of skin that peel off significantly reduces, and therapeutic effect is without bright
Significant difference is different.
The studies above result shows Xinjiang dimension medicine asafoetide root extract in Integral animal experiment and small sample crowd experiment
Can make psoriatic lesion be improved significantly, illustrate that asafoetide root extract has significant protective effect to Pigs with Psoriasis.
Using technical solutions according to the invention, or those skilled in the art is under the inspiration of technical solution of the present invention,
Similar technical scheme is designed, and reaches above-mentioned technique effect, is to fall into protection scope of the present invention.
Claims (7)
1. a kind of ointment of the treatment psoriasis based on asafoetide root extract composition, it is characterised in that the ointment is by following heavy
Measure the bulk drug composition of part：
Asafoetide root extract solution 50-150 parts, golden cypress 10-20 parts, safflower 10-20 parts, frankincense 20-30 parts, moisturizing substrate 50-100
Part；
The ointment is made by following methods：Bulk drug is weighed by above-mentioned parts by weight, first processes golden cypress, safflower and frankincense
After dry, crush, crude drug powder of sieving to obtain, then the crude drug powder and asafoetide root extract solution are obtained by extraction extract solution, then by extract solution
Blended with moisturizing substrate and the ointment is made.
2. the ointment of the treatment psoriasis as claimed in claim 1 based on asafoetide root extract composition, it is characterised in that described
The ointment of the treatment psoriasis based on asafoetide root extract composition specifically use 100 parts of asafoetide root extract solution, 15 parts of golden cypress, hide
15 parts of safflower, 25 parts of frankincense, 80 parts of moisturizing substrate.
3. the ointment of the treatment psoriasis as claimed in claim 1 based on asafoetide root extract composition, it is characterised in that described
The acquisition of asafoetide root extract solution use following steps：
Step 1：Choose high-quality asafoetide rhizome；
Step 2：Asafoetide rhizome is shredded and squeezes juice；
Step 3：Evaporation purification obtains asafoetide root extract solution.
4. the acquisition of asafoetide root extract solution as claimed in claim 3, it is characterised in that in step 1, described high-quality Ah
Wei's rhizome refers to Ferula sinkiangensis or the rhizome meristematic zone of Ferula fukanensis K.M.Shen or elongation zone.
5. the acquisition of asafoetide root extract solution as claimed in claim 3, it is characterised in that in step 2, asafoetide rhizome is cut
It is cut into 2mm to 5mm segment and is squeezed 20 to 30 minutes using Chinese medicine slag squeezer and obtains asafoetide root extract solution first product.
6. the acquisition of asafoetide root extract solution as claimed in claim 3, it is characterised in that in step 3, asafoetide root is extracted
Liquid first product inserts decompression Rotary Evaporators evaporation and obtains asafoetide root extract solution in 30 to 50 minutes.
7. the ointment of the treatment psoriasis as claimed in claim 1 based on asafoetide root extract composition, it is characterised in that described
Moisturizing substrate be vaseline.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710559782.6A CN107456510A (en) | 2017-07-11 | 2017-07-11 | A kind of ointment of the treatment psoriasis based on asafoetide root extract composition |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710559782.6A CN107456510A (en) | 2017-07-11 | 2017-07-11 | A kind of ointment of the treatment psoriasis based on asafoetide root extract composition |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1166339A (en) * | 1996-05-24 | 1997-12-03 | 王同振 | Heat-clearing plaque-eliminating bolus for curing psoriasis |
| CN104721279A (en) * | 2015-03-04 | 2015-06-24 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine ointment for treating psoriasis and preparation method thereof |
| CN106138733A (en) * | 2016-07-30 | 2016-11-23 | 韩梅 | One treats dermopathic Chinese medicinal ointment preparation and preparation method thereof |
| CN106237203A (en) * | 2016-10-21 | 2016-12-21 | 吉林省圣奥生物科技有限公司 | Treat psoriatic ointment |
-
2017
- 2017-07-11 CN CN201710559782.6A patent/CN107456510A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1166339A (en) * | 1996-05-24 | 1997-12-03 | 王同振 | Heat-clearing plaque-eliminating bolus for curing psoriasis |
| CN104721279A (en) * | 2015-03-04 | 2015-06-24 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine ointment for treating psoriasis and preparation method thereof |
| CN106138733A (en) * | 2016-07-30 | 2016-11-23 | 韩梅 | One treats dermopathic Chinese medicinal ointment preparation and preparation method thereof |
| CN106237203A (en) * | 2016-10-21 | 2016-12-21 | 吉林省圣奥生物科技有限公司 | Treat psoriatic ointment |
Non-Patent Citations (2)
| Title |
|---|
| 于均峰，等: "维药阿魏提取物阿魏酸在小鼠银屑病样皮肤损害中保护作用的研究", 《中国中西医结合皮肤性病学杂志》 * |
| 张文义: "《内病外治临床指南》", 31 July 2016, 北京：中医古籍出版社 * |
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Application publication date: 20171212 |