CN106924443A - It is a kind of to treat external application oil of senile skin pruritus and preparation method thereof - Google Patents
It is a kind of to treat external application oil of senile skin pruritus and preparation method thereof Download PDFInfo
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- CN106924443A CN106924443A CN201710219873.5A CN201710219873A CN106924443A CN 106924443 A CN106924443 A CN 106924443A CN 201710219873 A CN201710219873 A CN 201710219873A CN 106924443 A CN106924443 A CN 106924443A
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- 208000003251 Pruritus Diseases 0.000 title claims abstract description 67
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 239000003921 oil Substances 0.000 claims abstract description 59
- 235000019198 oils Nutrition 0.000 claims abstract description 59
- 239000000341 volatile oil Substances 0.000 claims abstract description 56
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- 239000008170 walnut oil Substances 0.000 claims abstract description 13
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Abstract
External application fluid composition of senile skin pruritus and preparation method thereof is treated the present invention relates to a kind of.External application oil is mainly made up of 0.5~10 part of 1~35 part of agilawood essential oil, 1~25 part of osmanthus leaf essential oil, 1~20 part of peony seed oil, 1~20 part of walnut oil, 1~20 part of coriander seed oil, 1~15 part of fructus cannabis oil, 1~15 part of white sesameseed oil, 1~10 part of Essential Oil From Pine Needles, 1~10 part of cactus seed oil, 1~10 part of egg flower essential oil, 1~10 part of citron oil and peppermint oil by weight.Through clinical trial certificate, this product total effective rate is 97%, and cure rate is 74.7%, recurrence rate is 2.8%, have no side effect, treatment senile skin pruritus are evident in efficacy, side reaction is few, recurrence rate is low, and have the advantages that short treating period, medication be convenient, low-cost, preparation method is simple.
Description
Technical field
External application fluid composition of senile skin pruritus and preparation method thereof is treated the present invention relates to a kind of.
Background technology
Senile skin pruritus are a kind of common skin diseases of the elderly, are mainly in more than 60 years old, and male is more than women,
Clinical manifestation often only has pruritis and is damaged without primary cutaneous.The course of disease of senile skin pruritus is touching refractory, Chang Qi
Itch unbearably and lack effective treatment means, have a strong impact on the physical and mental health of gerontal patient, reduce the quality of life of the elderly,
Most of patients is with depression and anxiety, irritated or emotional instability, and unhealthy emotion can aggravate gargalesthesia.Drink, emotional change,
Caloric stimulation, even some hints can induce itch or aggravate itch.According to statistics, senile skin pruritus are the elderlys
Most common pruritic disease, the incidence of disease is up to about 40.7%.With the trend of China human mortality aging, geroderma itch
Disease increasingly causes the attention of people, the treatment of pruritus senilis by be China clinician particularly dermatologist face it is tight
High challenge.
Senile skin pruritus pathogenesis is complicated, is not yet fully apparent from present.Its cause of disease has Physiological factors and disease
Rational factors, Physiological factors are mainly the degenerative change of the elderly's skin texture and function, skin immune function controlling change and
Endocrine Levels change；Pathology sexual factor is then abnormal and refreshing with some systemic diseases such as diabetes, habitual constipation, thyroid gland
It is relevant through weak grade.Belong to categories such as " pruritus ", " pruritus due to wind pathogen " of the traditional Chinese medical science.The traditional Chinese medical science thinks, this cause of disease can be divided into internal cause and outer
Cause, internal cause is how relevant with internal organs qi and blood, and external cause Chang Yufeng, wet, hot, worm are relevant.For the treatment of senile skin pruritus, mesh
It is preceding still to lack effective treatment method.To most of senile skin pruritus patients frequently with antihistamine, sugared skin in clinic
Local treatment based on matter hormone, endogenous hemp etc., for bigot, often needs to give antihistamine, immunodepressant, resists
Depressant drug etc. carries out systematic treating.Although western modern medicine is responded well to treatment comparatively fast, be easy to recurrence, if long-term use also easily produce it is resistance to
Receive, and side effect easily occur, therefore, limit its clinical practice.
The content of the invention
To overcome disadvantages described above, the present invention to supply a kind of for treating senile skin pruritus external application oil.
External application oil is mainly made up of following raw materials according by weight：1~35 part of agilawood essential oil, 1~25 part of osmanthus leaf essential oil,
1~20 part of peony seed oil, 1~20 part of walnut oil, 1~20 part of coriander seed oil, 1~15 part of fructus cannabis oil, white sesameseed oil 1~15
Part, 1~10 part of Essential Oil From Pine Needles, 1~10 part of cactus seed oil, 1~10 part of egg flower essential oil, 1~10 part of citron oil, peppermint oil
0.5~10 part.
Optimization formula is：Agilawood essential oil 5-20 parts, 5-15 parts of osmanthus leaf essential oil, peony seed oil 10-20 parts, walnut oil 10-15
Part, coriander seed oil 10-20 parts, fructus cannabis oil 5-10 parts, 7.5-10 parts of white sesameseed oil, Essential Oil From Pine Needles 5-8 parts, cactus seed oil
5-8 parts, 2.5-4 parts, citron oil 2-4 parts, peppermint oil 0.5-2.5 parts of egg flower essential oil.
Optimization formula is：20 parts of agilawood essential oil, 15 parts of osmanthus leaf essential oil, 10 parts of peony seed oil, 10 parts of walnut oil, coriander seed oil
10 parts, 10 parts of fructus cannabis oil, white sesameseed oil 7.5 parts, 5 parts of Essential Oil From Pine Needles, 5 parts of cactus seed oil, 5 parts of egg flower essential oil, Chinese holly
Rafter oil 2 parts, 0.5 part of peppermint oil.
The external application oil can also include appropriate amount of auxiliary materials base oil.The preferred camellia seed oil of auxiliary material base oil.
The preparation method of external application oil of the present invention, comprises the following steps：
(1) raw material is mixed by proportioning, is stirred, obtain mixture oil；
(2) 10~60 parts of appropriate amount of auxiliary materials base oil is added in the mixture oil obtained by step (1), at 35~42 DEG C,
Homogeneous 30~60 minutes, packing.
The present invention is based on the understanding and the rules for the treatment of of the traditional Chinese medical science and modern medicine to senile skin pruritus, using Chinese medicine or natural
The characteristics of vegetable oil is rapid-action, penetration is strong, using 12 kinds of Chinese medicines or the essential oil of natural plants, according to theory of traditional Chinese medical science and modern times
Theory of medicine prescription, is prepared from according to a certain ratio.Through clinical trial certificate：Total effective rate is 97%, and cure rate is
74.7%, recurrence rate is 2.8%, is had no side effect.External application oil treatment senile skin pruritus of the present invention are evident in efficacy, side reaction
Less, recurrence rate is low, and has the advantages that short treating period, medication be convenient, low-cost, preparation method is simple.
Specific embodiment
With reference to specific embodiment, the present invention is described further.
First, the preparation of laboratory sample
(1) sample one is formulated：20 parts of agilawood essential oil, 15 parts of osmanthus leaf essential oil, 10 parts of peony seed oil, 10 parts of walnut oil, coriander
10 parts of seed oil, 10 parts of fructus cannabis oil, 7.5 parts of white sesameseed oil, 5 parts of Essential Oil From Pine Needles, 5 parts of cactus seed oil, egg flower essential oil 5
Part, 2 parts of citron oil, 0.5 part of peppermint oil.
(2) sample two is formulated：15 parts of agilawood essential oil, 10 parts of osmanthus leaf essential oil, 15 parts of peony seed oil, 15 parts of walnut oil, coriander
Seed oil 12 parts, 8 parts of fructus cannabis oil, white sesameseed oil 8 parts, 5 parts of Essential Oil From Pine Needles, 5 parts of cactus seed oil, 2.5 parts of egg flower essential oil,
2 parts of citron oil, 2.5 parts of peppermint oil.
(3) sample three is formulated：5 parts of agilawood essential oil, 5 parts of osmanthus leaf essential oil, 20 parts of peony seed oil, 10 parts of walnut oil, coriander seed
20 parts of oil, 5 parts of fructus cannabis oil, 10 parts of white sesameseed oil, 8 parts of Essential Oil From Pine Needles, 8 parts of cactus seed oil, 4 parts of egg flower essential oil, Chinese holly
Rafter oil 4 parts, 1 part of peppermint oil.
(4) sample four is formulated：35 parts of agilawood essential oil, 25 parts of osmanthus leaf essential oil, 1 part of peony seed oil, 1 part of walnut oil, coriander seed
1 part of oil, 15 parts of fructus cannabis oil, 15 parts of white sesameseed oil, 1 part of Essential Oil From Pine Needles, 1 part of cactus seed oil, 10 parts of egg flower essential oil, Chinese holly
Rafter oil 10 parts, 10 parts of peppermint oil.
(5) preparation method：Raw material is mixed by formula, is stirred, obtain vegetable oil mixt, add 10~60
The medicinal camellia seed oil of part, at 35~42 DEG C, homogeneous 30~60 minutes, packing is for external application.
(6) it is formulated the source of each component：
Agilawood essential oil：It is to contain tree from Isolated From Thymelaeaceae Species plant suspension culture of Aquilaria sinensis Aquilaria sinensis (Lour.) Gilg
The essential oil extracted in the timber of fat.Its preparation method：Agalloch eaglewood medicinal material is chosen, cleaned, dry, crushed, use supercritical carbon dioxide
Extraction complexes are obtained by extraction agilawood essential oil.
Osmanthus leaf essential oil：It is to be extracted from the leaf of Oleaceae plants sweet-scented osmanthus Osmanthus fragrans (Thunb.) Lour.
Essential oil.Its preparation method：Osmanthus leaf is chosen, cleaned, dried, Gui Ye is obtained by extraction with supercritical carbon dioxide extracting complexes
Essential oil.
Peony seed oil：It is to be extracted from the seed of ranunculaceae peony (Paeonia suffruticosa Andr.)
Oil.Its preparation method：Peony seeds are chosen, is dried, peony seed oil is obtained by extraction with supercritical carbon dioxide extracting complexes.
Walnut oil：It is the oil extracted from the dry mature kernal of juglandaceae plant English walnut Juglans regia L..Its
Preparation method：Walnut kernel is chosen, is dried, walnut oil is obtained by extraction with supercritical carbon dioxide extracting complexes.
Coriander seed oil：It is to bring up in the ripe seeds of Sui Coriandrum sativum L. to carry from Umbelliferae coriander platymiscium
The oil for taking.Its preparation method：Coriander seed is chosen, is dried, coriander seed is obtained by extraction with supercritical carbon dioxide extracting complexes
Oil.
Fructus cannabis oil:It is the oil extracted from the dry mature fruit of moraceae plants hemp Cannabis sativa L..
Its preparation method：Fructus cannabis is chosen, is dried, fructus cannabis oil is obtained by extraction with supercritical carbon dioxide extracting complexes.
White sesameseed oil:It is the oil extracted from the seed of Pedaliaceae flax platymiscium sesame Sesamum indicum L..
Its preparation method：White sesameseed is chosen, is dried, white sesameseed oil is obtained by extraction with supercritical carbon dioxide extracting complexes.
Essential Oil From Pine Needles:It is from pinaceae plant Huashan pine (Pinus armandii Franch.), Pinus taiwanesis (Pinus
Taiwanensis Hayata), masson pine (Pinus massoniana Lamb.), black pine (Pinus thunbergii
Parl.), Chinese pine (Pinus tabuliformis Carriere), pinus yunnanensis (Pinus yunnanensis), Korean pine (Pinus
Koraiensis Sieb.et Zucc.) etc. needle in extract essential oil.Its preparation method：Pine needle is chosen, with overcritical two
Carbonoxide extraction complexes are obtained by extraction pinke needle oil.
Cactus seed oil:It is from Cactaceae opuntia cactus Opuntia stricta (Haw.)
The oil extracted in the seed of Haw.var.dillenii (Ker-Gawl.) Benso.Its preparation method：Cactus seed is chosen, is shone
It is dry, cactus seed oil is obtained by extraction with supercritical carbon dioxide extracting complexes.
Egg flower essential oil:It is the essential oil for spending middle extraction from apocynaceae plant frangipanis Plumeria rubra L..Its
Preparation method：Frangipanis is chosen, cleaned, dried, egg flower essential oil is obtained by extraction with supercritical carbon dioxide extracting complexes.
Citron oil:It is to be extracted from the fresh full fruit of rutaceae lemon Citrus limon (L.) Burm. or pericarp
Oil.Its preparation method：Fresh full fruit or the pericarp of lemon are chosen, is obtained by extraction with supercritical carbon dioxide extracting complexes
Citron oil.
Peppermint oil:It is the fresh stem and Ye Jing vapor from labiate peppermint Mentha haplocalyx Briq.
The volatile oil that distillation, freezing, the de- brain processing in part are extracted.
2nd, clinical effect trial
(1) physical data
Present invention treatment senile skin pruritus patient 75.Age reckling is 60 years old, and the maximum is 85 years old, averagely
71.5 years old age；It is the course of disease most short half a year, most long 24 years.Wherein, course of disease person 5,1~5 year person 25, more than 5 years persons within 1 year
45.
(2) case selection
1. diagnostic criteria：Western medicine diagnostic criteria reference《Clinical dermatology》In relevant standard draft, whole skin scabies
Itch acutely, in the absence of primary skin damaged, skin can produce the Secondary cases such as scratch, scab and pigmentation after being scratched repeatedly because of itch
Infringement；Autumn and winter is mainly in, and is more common in gerontal patient.Tcm diagnosis standard reference《Newly organized Dermatology of Traditional Chinese Medicine》In it is relevant
The diagnostic criteria of " pruritus due to wind pathogen " is drafted, and onset only has itch and without primary fash；Acute pruritus, are often paroxysmal, especially with night
Between for very；Repeatedly, frequently scratching can secondary scratch, scab, the fash such as pigmentation and the coarse, lichenification of pachyderma.
2. inclusion criteria：Meet above-mentioned doctor trained in Western medicine and tcm diagnosis standard person, the age is between 60~85 years old.
3. exclusion standard：Senile skin pruritus doctor trained in Western medicine and tcm diagnosis standard person are not met；Because of severe cardiac, kidney, liver
The cutaneous pruritus patient that the internal disease such as disease and diabetes, autoimmune disease causes；Other skin diseases such as neurodermatitis, wet
The patients such as rash；Taken in treatment is first 1 month in corticosteroid hormone, 1 week and take any antihistamine drug person；During treatment
Arbitrarily stop or change treatment method and medicine person.
(3) treatment method
External application oil of the present invention is applied directly to pruitus position, by massaging way allow oil infiltrate into epiderm skin and
Hypodermis, it is sooner or later each 1 time daily, it is within 4 weeks to be rested 1 day between 1 course for the treatment of, the course for the treatment of, continuously carrying out curative effect after 2 courses for the treatment of of treatment comments
Valency.
(4) curative effect determinate standard
1. curative effect observation index：
Using 4 grades of scoring system in post-therapeutic evaluation symptoms and sign：1. itch：Without itch situation, 0 point is remembered；Slight itch patient can be with
Stand, do not influence daily life, remember 3 points；Moderate itch patient can be stood, and daily life is influenceed sometimes, remember 6 points；Severe scabies
The patient that itches feels and cannot stand, hence it is evident that influence daily life, remembers 9 points.2. scratch and scab：Remember 0 point without scratch and scab；It is local
A small amount of scratch, scab remember 1 point；Scratch, scab distribution many places remember 2 points；Scratch, scab spread all over whole body and remember 3 points.3. dry skin journey
Degree：Without 0 point of the scales of skin that peel off, moist note；Slight to dry, skin has carefully 1 point of scales of skin that peel off person's note less after scratching；Dry skin is heavier and has
Tight feeling, the scales of skin that peel off remembers 2 points in the form of sheets；Dry skin is very serious, is even chapped with mild pain, hence it is evident that furfur remembers 3 points.4. skin
Lichenification：Skin lichenification does not remember 0 point；Lichenification relatively limit to and also substantially remember 1 point；Lichenification moderate note 2
Point；Lichenification is more, plump 3 points of the note of skin damaged.Each item rating sum is Clinical points, and highest scoring is 18 points.Symptom integral
Decline integration × 100% before index=(being integrated after the treatment of integration one before treatment)/treatment.
2. the standard of curative effect evaluation
With reference to " new Chinese medicine treats the guideline of clinical investigations curative effect determinate standard of pruritus due to wind pathogen " and relevant document system
It is fixed.Recovery from illness：Whole body pruritis feel and are wholly absent that the skin damaged such as secondary drying, furfur, lichenification, scab disappears, symptom
Integration declines index >=90%；It is effective：Feel that whole body itch substantially mitigates, secondary drying, furfur, lichenification, scab etc.
Skin damaged is most of substantially to disappear, and symptom integral declines index >=70%, but ＜ 90；Effectively：Feel that pruritis mitigate, it is local after
Hair skin damaged has been taken on a new look, and symptom integral declines index >=30%, but ＜ 70%；It is invalid：Conscious itch is not improved, it is local after
Hair skin damaged is unchanged, and symptom integral declines index ＜ 30%.
(5) adverse reaction and prognosis
The clinical adverse that patient occurs in record therapeutic process.And after the treatment further consultation in 1 year and Effect of follow-up visit by telephone seeing
Examine patient's prognosis.
(6) treatment results
1st, the treatment results of sample one
75 senile skin pruritus patients are controlled by above-mentioned treatment method application external application fluid composition sample one of the present invention
After treating 2 courses for the treatment of, the skin damaged symptom such as pruritis and secondary drying, furfur, lichenification, scratch, scab of 72 patients
Substantially disappear.Wherein, recovery from illness case 56 (cure rate is 74.7%), effective case 10 (obvious effective rate is 13.3%) has
Effect case 6 (effective percentage is 8%), Ineffective Cases 3 (inefficiency is 4%), total effective rate is 97%.Treatment before and after itch and
Before symptom skin damaged is integrated by treating 15.83 ± 1.01 drop to 0.91 ± 0.22 (through statistics, P<0.01, it is poor with conspicuousness
It is different).1 year after 2 course of therapy, there are 2 recovery from illness cases to recur, 1 effective case pruritis and secondary drying occurs, takes off
The skin damaged exacerbation of symptoms such as bits, lichenification, scratch, scab, recurrence rate is 2.8%, but the pruritis and secondary after recurrence
The skin damaged symptom such as drying, furfur, lichenification, scratch, scab degree substantially mitigates before relatively treating, and continuing medication symptom can be quickly
Alleviate or disappear.Additionally, patient does not occur the clinical adverse relevant with the present invention in whole therapeutic process.
It is attached：Model case
Lee, man, 77 years old.The application of on December 15,15 days to 2015 October in 2015 is the present invention treat.
Main suit：Trunk and limbs skin itch more than 5 years repeatedly.Itch adds after being had a bath with winter and night heat or hot water
Weight, has a strong impact on sleep and mental status.It is " senile skin pruritus " repeatedly to be examined in hospital from 2010, once took and dispels
The antipruritic class Chinese medicine of wind and levo-cetirizine hydrochloride tablets etc., itch slightly mitigates after medication, but after one week or so and repeatedly.Patient also makes
, originally effectively, but after one or two week, there is reduction evident in efficacy in the external preparations such as used calamine lotion, corticosteroid ointment
Even invalid phenomenon.
Have a medical check-up：Patient's trunk, limbs skin have no primary skin damaged, but see that obvious scratch, scab and local skin are coarse
Thicken.Systems inspection and auxiliary examination Non Apparent Abnormality.
Diagnosis：Doctor trained in Western medicine is diagnosed as senile skin pruritus；Tcm diagnosis are pruritus due to wind pathogen.
Treatment：External application oil of the present invention is applied directly to pruitus position, allows oil to infiltrate into skin by massaging way
Epidermis and hypodermis, it is sooner or later each 1 time daily, it is within 4 weeks to be rested 1 day between 1 course for the treatment of, the course for the treatment of, continuously carried out after 2 courses for the treatment of of treatment
Therapeutic evaluation.
As a result：After treatment 3 days, itch substantially mitigates；After treating 2 weeks, scratch and scab partial remission；1 course for the treatment of of treatment
Afterwards, the Secondary cases such as drying, furfur, lichenification, scratch, scab skin damaged symptom disappears substantially, and whole body itch disappears substantially, sleep
And mental status are obviously improved；After 2 courses for the treatment of of treatment, the Secondary cases skin damaged symptom such as drying, furfur, lichenification, scratch, scab
All disappear, whole body itch is wholly absent, sleep and mental status recover to normal.No recurrence was observed during the follow-up period of 6 months；Follow-up 1 year,
When heat is dried, there is slight itch 1 time in local skin, and symptom is wholly absent after continuing medication 2 days.
2nd, the treatment results of sample two
65 senile skin pruritus patients are controlled by above-mentioned treatment method application external application fluid composition sample two of the present invention
After treating 2 courses for the treatment of, the skin damaged symptom such as pruritis and secondary drying, furfur, lichenification, scratch, scab of 60 patients
Substantially disappear.Wherein, recovery from illness case 47 (cure rate is 72.31%), effective case 8 (obvious effective rate is 12.31%) has
Effect case 5 (effective percentage is 7.69%), Ineffective Cases 5 (inefficiency is 7.69%), total effective rate is 92.31%.Treatment
Before front and rear itch and symptom skin damaged are integrated by treating 16.34 ± 2.32 drop to 1.52 ± 0.35 (through statistics, P<0.01, tool
There is significant difference).1 year after 2 course of therapy, there is 3 recurrences, recurrence rate is 4.2%, but recurrence after pruritis and after
The skin damaged symptom such as drying, furfur, lichenification, scratch, scab of hair degree substantially mitigates before relatively treating, and continuing medication symptom can
Alleviate quickly or disappear.Additionally, patient does not occur the clinical adverse relevant with the present invention in whole therapeutic process.
3rd, the treatment results of sample three
82 senile skin pruritus patients are controlled by above-mentioned treatment method application external application fluid composition sample three of the present invention
After treating 2 courses for the treatment of, the skin damaged symptom such as pruritis and secondary drying, furfur, lichenification, scratch, scab of 72 patients
Substantially disappear.Wherein, recovery from illness case 55 (cure rate is 67.07%), effective case 12 (obvious effective rate is 14.63%),
Effective case 5 (effective percentage is 4.87%), Ineffective Cases 5 (inefficiency is 7.69%), total effective rate is 87.80%.Control
Before itch and symptom skin damaged integration are by treating before and after treating 14.98 ± 1.52 drop to 2.91 ± 0.32 (through statistics, P<0.01,
With significant difference).1 year after 2 course of therapy, there are 6 recurrences, recurrence rate is 8.33%, but the pruritis after recurrence
And the skin damaged symptom degree such as secondary drying, furfur, lichenification, scratch, scab relatively treat before substantially mitigate, continue medication disease
Shape can quickly be alleviated or disappear.Additionally, in whole therapeutic process patient do not occur it is relevant with the present invention clinical bad anti-
Should.
4th, the treatment results of sample four
34 senile skin pruritus patients are controlled by above-mentioned treatment method application external application fluid composition sample four of the present invention
After treating 2 courses for the treatment of, the skin damaged symptom such as pruritis and secondary drying, furfur, lichenification, scratch, scab of 28 patients
Substantially disappear.Wherein, recovery from illness case 20 (cure rate is 58.82%), effective case 2 (obvious effective rate is 5.9%), effectively
Case 6 (effective percentage is 17.64%), Ineffective Cases 6 (inefficiency is 17.64%), total effective rate is 82.36%.Treatment
Before front and rear itch and symptom skin damaged are integrated by treating 14.33 ± 1.52 drop to 3.51 ± 0.86 (through statistics, P<0.01, tool
There is significant difference).1 year after 2 course of therapy, there is 4 recurrences, recurrence rate is 14.28%, but recurrence after pruritis and
The skin damaged symptom such as secondary drying, furfur, lichenification, scratch, scab degree substantially mitigates before relatively treating, and continues medication symptom
Can quickly alleviate or disappear.Additionally, patient does not occur the clinical adverse relevant with the present invention in whole therapeutic process.
Claims (6)
1. a kind of external application for treating senile skin pruritus is oily, it is characterised in that the external application oil is by weight mainly under
Row raw material is made：1~35 part of agilawood essential oil, 1~25 part of osmanthus leaf essential oil, 1~20 part of peony seed oil, 1~20 part of walnut oil, coriander
1~20 part of seed oil, 1~15 part of fructus cannabis oil, 1~15 part of white sesameseed oil, 1~10 part of Essential Oil From Pine Needles, cactus seed oil 1~10
Part, 1~10 part of egg flower essential oil, 1~10 part of citron oil, 0.5~10 part of peppermint oil.
2. external application according to claim 1 is oily, it is characterised in that the external application oil is by weight mainly by following raw materials according
It is made：Agilawood essential oil 5-20 parts, 5-15 parts of osmanthus leaf essential oil, peony seed oil 10-20 parts, walnut oil 10-15 parts, coriander seed oil 10-
20 parts, fructus cannabis oil 5-10 parts, 7.5-10 parts of white sesameseed oil, Essential Oil From Pine Needles 5-8 parts, 5-8 parts of cactus seed oil, egg anthosin
It is oily 2.5-4 parts, citron oil 2-4 parts, peppermint oil 0.5-2.5 parts.
3. external application according to claim 1 is oily, it is characterised in that the external application oil is by weight mainly by following raw materials according
It is made：20 parts of agilawood essential oil, 15 parts of osmanthus leaf essential oil, 10 parts of peony seed oil, 10 parts of walnut oil, 10 parts of coriander seed oil, fructus cannabis oil
10 parts, white sesameseed oil 7.5 parts, 5 parts of Essential Oil From Pine Needles, 5 parts of cactus seed oil, 5 parts of egg flower essential oil, 2 parts of citron oil, peppermint oil
0.5 part.
4. external application according to Claim 1-3 is oily, it is characterised in that：The external application oil also includes appropriate amount of auxiliary materials base oil.
5. external application according to claim 4 is oily, it is characterised in that：The auxiliary material base oil is camellia seed oil.
6. the oily preparation method of external application described in claim 1, it is characterised in that comprise the following steps：
(1) raw material is mixed by proportioning, is stirred, obtain mixture oil；
(2) 10~60 parts of medicinal camellia seed oils, at 35~42 DEG C, homogeneous 30 are added in the mixture oil obtained by step (1)
~60 minutes, packing.
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