CN102579514B - Method for processing alangium platanifolium - Google Patents
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Abstract
The invention provides a method which is applicable to process alangium platanifolium, as for the alangium platanifolium, alkaloid is not only the active ingredient but also the toxic ingredient of the alangium platanifolium. Consequently, the research on the method for safely and reasonably processing the drug is very important to improve the clinic medication safety of the drug. The method for processing the alangium platanifolium is scientific and reasonable, has stable technological parameters, can effectively improve the safety of the alangium platanifolium to realize the purposes of toxicity reduction and efficacy enhancement, and benefits industrial production.
Description
Technical field
The present invention relates to a kind of concocting method of Chinese medicine, particularly a kind of concocting method that is applicable to Chinese medicine Radix Alangii.
Background technology
Radix Alangii is dry radicula and the fibrous root of Alangiaceae plant Radix Alangii Alangium chinense (Lour.) Harms.Be distributed in the ground such as Yunnan, Guizhou, for ethnic groups makes medication.Have dispelling wind and removing obstruction in the collateral, the effects such as scattered silt analgesia, anesthesia and relaxed muscle, are used for the treatment of rheumatalgia, paralysis and numbness, heart failure, strain lumbago, traumatic injury etc.Its fibrous root and supporting root are containing alkaloid, acids, aminoacid, organic acid, resin etc.Radix Alangii, because of advantages such as its curative effect are reliable, medicine source is extensive, economy is convenient, has wide research and development prospect.
Radix Alangii alkaloid mainly exists in radicula, fibrous root and root bark, and wherein fibrous root content is the highest, and toxicity is also maximum.Modern pharmacological research shows: the effective ingredient of its myorelaxant effects is mainly alkaloid, but the toxicity of Radix Alangii mainly also comes from its contained alkaloid.Alkaloids composition is that the effective ingredient of Radix Alangii is also its toxic component.
Chinese Pharmacopoeia version First in 1977 has recorded the processing procedure of Chinese medicine Radix Alangii, specific as follows: remove impurity, clean, and slightly vexed, cutting, dry.The method is the conventional concocting method of Chinese medicine, and the Attenuation to medical material after the process of preparing Chinese medicine is not obvious, can not improve the drug safety of Radix Alangii.
Up to now, there is no a kind of effective reduction Radix Alangii toxicity can stablized, be convenient to the processing procedure of industrial applications.
Therefore, provide a kind of processing procedure that improves its safety that is applicable to Radix Alangii very necessary.
Summary of the invention
For Chinese medicine Radix Alangii, contained alkaloid (being mainly anabasine) is its effective ingredient and toxic component, and there is no now a kind of effectively concocting method of attenuation.
For this problem, the invention provides a kind of concocting method that is applicable to Radix Alangii, the method is with respect to frying, for yellow wine parch, can effectively reach attenuation and significantly not reduce the effect of drug effect, and processing procedure is scientific and reasonable, is convenient to suitability for industrialized production.
The concocting method of Radix Alangii provided by the invention, specific as follows:
1) get Radix Alangii medical material, select, be cut into long section, the long 15cm that is no more than;
2) prepare Sucus Glycyrrhizae: according to 1000 parts of clean medical materials of Radix Alangii, the ratio of 200 portions of Radix Glycyrrhizaes, takes Radix Glycyrrhizae.The Radix Glycyrrhizae weighing up is decocted 2 times, add 10 times of water gagings at every turn, decoct for the first time 2h, decoct for the second time 1h, decoct afterwards and filter, filtrate for later use;
3) according to 1000 parts of clean medical materials of Radix Alangii, the ratio of 500 portions of milk, adds milk in the above-mentioned Sucus Glycyrrhizae preparing, and adds the Radix Alangii medical material after above-mentioned cutting, adds water and complements to the volume of 14 times of amounts of clean medical material, decocts 2h, filters.
4) by the forced air drying at 45 ℃ ± 2 ℃ of Radix Alangii after boiling, to obtain final product.
Processing procedure provided by the invention, its consumption proportion is as follows: the clean medical material of every 1000g, use Radix Glycyrrhizae 200g, milk 500g.
Processing procedure step 1 provided by the invention) in, Radix Alangii medical material is pressed the cutting of 5cm/ section more.
The related decoction process of processing procedure provided by the invention is specially: first " intense fire " boils to boiling, then " slow fire " decocts.
For this concocting method, Radix Glycyrrhizae sweet in the mouth, property is flat.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain effect.Medicine can relax the property of medicine after Sucus Glycyrrhizae system, reduces toxicity.In Shennong's Herbal, just there is the record of Radix Glycyrrhizae " removing toxic substances ".Radix Glycyrrhizae main component is glycyrrhizic acid and liquirtin, reducing sugar, starch and gelatin substance etc.The glucuronic acid generating after glycyrrhizic acid hydrolysis has Detoxication, and liquirtin is surfactant simultaneously, can increase the dissolubility of other water insoluble materials.In tcm prescription, conventional Radix Glycyrrhizae is guiding drug, and coordinating the actions of various ingredients in a prescription also plays solubilization in the process of preparing Chinese medicine and decoction process.
Milk: conventional milk, as Auxiliary Liquid Material, arrives the effect that relaxes the property of medicine, reduces toxicity, heightens the effect of a treatment in ethnic drug big gun.
The specific embodiment
Below in conjunction with the specific embodiment, the present invention is further described in detail, the embodiment providing is only in order to illustrate the present invention, rather than in order to limit the scope of the invention.
embodiment 1: the concocting method of Radix Alangii
This experiment provides the processing procedure under various dose proportioning, wants to filter out the optimal processing parameter of Radix Alangii processing procedure from follow-up experiment.
Technique 1:
According to processing procedure step provided by the invention, according to every 1000 parts of Radix Alangii crude drugs, 100 portions of Radix Glycyrrhizaes, the proportioning of 250 portions of milk, concocts a collection of Radix Alangii, and concrete operations are as follows:
1) buy a collection of Radix Alangii medical material, select, be cut into long section, be about 5cm;
2) the Radix Alangii medical material after above-mentioned cutting is weighed, heavily about 2000g;
3) prepare Sucus Glycyrrhizae: take Radix Glycyrrhizae 200g, decoct 2 times, the 2L that at every turn adds water, first " intense fire " boils to boiling, then " slow fire " decocts.Decoct for the first time 2h, decoct for the second time 1h, decoct afterwards and filter, filtrate for later use;
4) the Radix Alangii medical material after above-mentioned weighing is put into decoction pot, adds above-mentioned steps 3) in the Sucus Glycyrrhizae for preparing, then add 500g milk, then add water that to complement to total decocting liquid volume be 28L, decoct 2h, filter;
5) by the forced air drying at 45 ℃ ± 2 ℃ of Radix Alangii after boiling, to obtain final product.
Technique 2:
According to processing procedure step provided by the invention, according to every 1000 parts of Radix Alangii crude drugs, 200 portions of Radix Glycyrrhizaes, the proportioning of 500 portions of milk, concocts a collection of Radix Alangii, and concrete operations are as follows:
1) buy a collection of Radix Alangii medical material, select, be cut into long section, be about 5cm;
2) the Radix Alangii medical material after above-mentioned cutting is weighed, heavily about 2000g;
3) prepare Sucus Glycyrrhizae: take Radix Glycyrrhizae 400g, decoct 2 times, the 4L that at every turn adds water, first " intense fire " boils to boiling, then " slow fire " decocts.Decoct for the first time 2h, decoct for the second time 1h, decoct afterwards and filter, filtrate for later use;
4) the Radix Alangii medical material after above-mentioned weighing is put into decoction pot, adds above-mentioned steps 3) in the Sucus Glycyrrhizae for preparing, then add 1000g milk, then add water that to complement to total decocting liquid volume be 28L, decoct 2h, filter;
5) by the forced air drying at 45 ℃ ± 2 ℃ of Radix Alangii after boiling, to obtain final product.
Technique 3:
According to processing procedure step provided by the invention, every 1000 parts of Radix Alangii crude drugs, 400 portions of Radix Glycyrrhizaes, the proportioning of 1000 portions of milk, concocts a collection of Radix Alangii, and concrete operations are as follows:
1) buy a collection of Radix Alangii medical material, select, be cut into long section, be about 5cm;
2) the Radix Alangii medical material after above-mentioned cutting is weighed, heavily about 2000g;
3) prepare Sucus Glycyrrhizae: take Radix Glycyrrhizae 800g, decoct 2 times, the 8L that at every turn adds water, first " intense fire " boils to boiling, then " slow fire " decocts.Decoct for the first time 2h, decoct for the second time 1h, decoct afterwards and filter, filtrate for later use;
4) the Radix Alangii medical material after above-mentioned weighing is put into decoction pot, adds above-mentioned steps 3) in the Sucus Glycyrrhizae for preparing, then add 2000g milk, then add water that to complement to total decocting liquid volume be 28L, decoct 2h, filter;
5) by the forced air drying at 45 ℃ ± 2 ℃ of Radix Alangii after boiling, to obtain final product.
embodiment 2:
different concocting methods are concocted the comparative study of rear Radix Alangii acute toxicity and the effect of flesh pine
1 experiment material
1.1 Experimental agents
No. 1 sample: the raw product of Radix Alangii medical material (not concocting), amounting to crude drug amount is 1.08g/g, lot number: SP001.
No. 2 samples: medicine after the parch of Radix Alangii medical material yellow wine (it is clear-cut that every 1000g crude drug adds 100g yellow wine to fry to sample), amounting to crude drug amount is 1.25g/g, lot number: PZP001.
No. 3 samples: Radix Alangii medical material is fried rear medicine (it is clear-cut to fry to sample), amounting to crude drug amount is 1.30g/g, lot number: PZP002.
No. 4 samples: medicine (concocting by the technique 1 providing in embodiment 1) after the boiling of Radix Alangii medical material Radix Glycyrrhizae milk, amounting to crude drug amount is 1.14g/g, lot number: PZP003.
No. 5 samples: medicine (concocting by the technique 2 providing in embodiment 1) after the boiling of Radix Alangii medical material Radix Glycyrrhizae milk, amounting to crude drug amount is 1.18g/g, lot number: PZP004.
No. 6 samples: medicine (concocting by the technique 3 providing in embodiment 1) after the boiling of Radix Alangii medical material Radix Glycyrrhizae milk, amounting to crude drug amount is 1.26g/g, lot number: PZP005.
Above medicine provides by Beijing ChuangLi KeChuang Medicine Technology Development Co., Ltd.Before test, be all made into the suspension of suitable concentration with 0.5%CMC-Na for subsequent use.
1.2 laboratory animal
Kunming kind white mice, body weight 19-21g or 20-22g, male and female half and half, purchased from Changchun Biological Products Institute, the mice quality certification number: 2006-0001.
2 experimental techniques and result
2.1 impacts of different concocting methods on Radix Alangii sample LD50
Get 420 of above-mentioned mices, be divided at random 6 groups, 70 every group, fasting can't help water after 16 hours respectively gavage give distinct methods concoct after Radix Alangii sample suspension, once, volume is 40ml/kg to gavage.Diet, activity, feces, body weight, fur glossiness and the living or death situation of two weeks interior animals after observation administration, observe nose, eye, oral cavity simultaneously and have or not abnormal secretion thing, and dead animal is dissected in time to the pathological change situation of the main organs such as the perusal heart, liver, spleen, lung, kidney.Adopt " Bliss method " to calculate 6 sample LD50, the results are shown in Table 1.
The impact of the different concocting methods of table 1 on Radix Alangii sample LD50
(note: ▲ representative is compared with No. 1 sample, P < 0.05)
As shown in Table 1, most animals in 3-20 minute, starts to occur also death successively of poisoning symptom: first animal shows as quiet few moving after administration, rapid breathing then, and front general tremor, struggle on one's deathbed holds down, and indivedual animal hind legs are stiff.Surviving animals is basic after approximately 40 minutes recovers normal.Dead animal is dissected in time, and the perusal heart, liver, spleen, lung, kidney are showed no obvious abnormalities change.
No. 1 sample animal dead percentage rate is respectively 100%, 70%, 70%, 50%, 40%, 20%, 10%, and LD50 is 3.0433g/kg (amounting to crude drug amount is 3.2868g/kg).
No. 2 sample animal dead percentage rate is respectively 90%, 80%, 70%, 50%, 10%, 10%, and LD50 is 3.1026g/kg (amounting to crude drug amount is 3.8782g/kg).
No. 3 sample animal dead percentage rate is respectively 100%, 100%, 60%, 50%, 40%, 30%, 0%, and LD50 is 2.8481g/kg (amounting to crude drug amount is 3.7025g/kg).
No. 4 sample animal dead percentage rate is respectively 90%, 80%, 70%, 60%, 40%, 20%, 0%, and LD50 is 4.2631g/kg (amounting to crude drug amount is 5.0412g/kg).
No. 5 sample animal dead percentage rate is respectively 90%, 80%, 60%, 50%, 40%, 20%, 10%, 0%, and LD50 is 4.4102g/kg (amounting to crude drug amount is 5.2040g/kg).
No. 6 sample animal dead percentage rate is respectively 90%, 80%, 70%, 50%, 30%, 20%, 20%, 0%, and LD50 is 4.1728g/kg (amounting to crude drug amount is 4.9762g/kg).
6 sample toxicity size orders are followed successively by: No. 5 samples of No. 4 sample > of No. 6 sample > of No. 2 sample > of No. 3 sample > of No. 1 sample >.Visible, above-mentioned concocting method all has certain Attenuation to Radix Alangii medical material, and with 4,5, No. 6 the most obviously (P < 0.05) of sample Attenuation, No. 5 samples relative No. 4 and No. 6 samples, Attenuation is better, but difference is not remarkable, illustrate that concocting method provided by the invention is the strongest to the Attenuation of Radix Alangii, the Radix Alangii Attenuation of wherein concocting with the processing procedure parameter of No. 5 samples is best.
2.2 impacts of different concocting methods on Radix Alangii sample ED50
This experiment adopts " climbing net method " to test the impact of the flesh pine effect of different concocting methods on Radix Alangii, specific as follows: wire gauze and desktop are 60 ° of angles, and mice is put on the net, lets alone to seek connections with and creeps, and observes 60 minutes, and it is qualified not falling person.
Mice qualified screening (240, be divided into 6 groups, 40 every group at random) fasting be can't help to water 16 hours, and gavage gives the Radix Alangii sample suspension after distinct methods is concocted respectively, and once, volume is 40ml/kg to gavage.After administration, mice is put on wire gauze, lets alone to seek connections with and creep, observe in 60 minutes and fall voluntarily situation.Voluntarily do not fall person, put back on the net, continuous 3 persons of falling are positive, represent that it is the effect of flesh pine that this medicine has extremity myoparalysis.Adopt " Bliss method " to calculate 6 sample ED50.Result is as shown in table 2.
The impact of the different concocting methods of table 2 on Radix Alangii sample ED50
(note: ▲ representative is compared with No. 1 sample, P < 0.05)
As shown in Table 2, No. 1 sample animal falls percentage rate and is respectively 90%, 90%, 70%, 60%, 60%, 20%, 10%, 0%, and ED50 is 1.2892g/kg (amounting to crude drug amount is 1.3957g/kg).
No. 2 sample animals fall percentage rate and are respectively 100%, 80%, 50%, 40%, 20%, 0%, and ED50 is 1.3241g/kg (amounting to crude drug amount is 1.7211g/kg).
No. 3 sample animals fall percentage rate and are respectively 90%, 70%, 60%, 50%, 20%, 10%, 0%, and ED50 is 2.0321g/kg (amounting to crude drug amount is 2.4009g/kg).
No. 4 sample animals fall percentage rate and are respectively 100%, 80%, 60%, 40%, 20%, 10%, 0%, and ED50 is 1.3074g/kg (amounting to crude drug amount is 1.5427g/kg).
No. 5 sample animals fall percentage rate and are respectively 90%, 80%, 60%, 40%, 20%, 10%, 0%, and ED50 is 1.2791g/kg (amounting to crude drug amount is 1.4862g/kg).
No. 6 sample animals fall percentage rate and are respectively 100%, 90%, 60%, 40%, 20%, 20%, 0%, and ED50 is 1.3237g/kg (amounting to crude drug amount is 1.6209g/kg).
ED50 from large to small order is: No. 1 sample of No. 5 sample > of No. 4 sample > of No. 6 sample > of No. 2 sample > of No. 3 sample >.Visible, the effect of the flesh of 4,5, No. 6 samples pine does not significantly reduce compared with No. 1 sample, and this result shows to utilize Radix Alangii after concocting method provided by the invention is concocted in the significantly reduced situation of toxicity, and drug effect does not significantly reduce.
2.3 impacts of different concocting methods on Radix Alangii safety
According to formula: therapeutic index (TI)=LD50/ED50, calculate TI, big or small, the impact of evaluating the safety of different concocting method Herba Astragali Bhotanensis maple with this, result is as shown in table 3.
The impact of the different concocting methods of table 3 on Radix Alangii safety
As shown in Table 3, therapeutic index TI is sequentially followed successively by from large to small: No. 3 samples of No. 1 sample > of No. 2 sample ≌ of No. 6 sample > of No. 4 sample > of No. 5 sample >.Because therapeutic index is larger, its safety is higher, otherwise lower.Therefore, No. 3 minimums of 6 secure samples of Radix Alangii, 1, No. 2 sample takes second place, and 4,5, No. 6 sample is better, and wherein No. 5 secure samples are the highest.This result shows to utilize the concocting method of Radix Alangii provided by the invention compared with other method, and after concocting, the safety of Radix Alangii is best.
3 experiment conclusion
Radix Alangii supporting root and root bark are containing alkaloid, acids, aminoacid, organic acid, resin; Fibrous root is mainly containing alkaloid and glucosides and cardiac glycoside.Radix Alangii alkaloid mainly exists in radicula, fibrous root and root bark, and wherein fibrous root content is the highest, and toxicity is also maximum.Modern pharmacological research shows: the effective ingredient of its myorelaxant effects is mainly alkaloid, but the toxicity of Radix Alangii mainly also comes from its contained alkaloid.Alkaloids composition is that the effective ingredient of Radix Alangii is also its toxic component.
For reaching the object of clinical practice attenuation synergistic, the present invention adopts 3 kinds of distinct methods to crude drug, and wherein three of a kind of method different technical parameters are concocted.And LD50 and ED50 that it is concocted to 6 samples in front and back, compare research, calculate TI simultaneously.Experimental result shows, 6 sample LD50 size orders of Radix Alangii are followed successively by No. 5 samples of No. 4 sample > of No. 6 sample > of No. 2 sample > of No. 3 sample > of No. 1 sample >.Visible, Radix Alangii medical material has all reached certain Attenuation after concocting, and especially obvious with No. 5 sample Attenuations; 6 sample ED50 are sequentially from large to small: No. 1 sample of No. 5 sample > of No. 4 sample > of No. 6 sample > of No. 2 sample > of No. 3 sample >.Visible, 4,5, No. 6 samples are the in the situation that of attenuation, and its flesh pine effect does not significantly reduce; The TI value of 6 samples, No. 3 sample minimums, 1, No. 2 sample takes second place, and 4,5, No. 6 sample is better.Because therapeutic index is larger, its safety is higher, otherwise lower.Therefore, No. 5 secure samples are best.
As fully visible, in 6 samples of Radix Alangii, utilize No. 5 sample Attenuation the bests, comprehensive safety after method provided by the invention is concocted best, the object of attenuation after the medicinal material processing substantially having reached, and its concoct after drug effect significantly do not reduce.
The stability test of embodiment 3 processing procedures of the present invention
3.1 in order to verify stability and the feasibility of processing procedure provided by the invention, and the present invention has completed the pilot scale of the Radix Alangii in 10 batches, 3 places of production and amplified research, and each batch sample is detected, and result is as shown in table 4.
10 batches of pilot scale amplification datas of table 4
3.2
The raw product of the different places of production of table 5 Radix Alangii and processed product anabasine assay result
3.3 study on the stability researchs
The present invention has carried out stability study at ambient temperature to 3 batches of pilot products of quantity-produced, has now completed the stability study work of 12 months, the results are shown in Table 6-8.Result shows that this product quality under this packing and condition of storage is basicly stable.
Table 6 Radix Alangii long-term stable experiment processed result table
The name of an article: Radix Alangii lot number processed: 20090601 dates of manufacture: in June, 2009
Table 7 Radix Alangii long-term stable experiment processed result table
The name of an article: Radix Alangii lot number processed: 20090602 dates of manufacture: 2009
June in year
Table 8 Radix Alangii long-term stable experiment processed result table
The name of an article: Radix Alangii lot number processed: 20090603 dates of manufacture: 2009
June in year
Claims (3)
1. a concocting method for Chinese medicine Radix Alangii, is characterized in that comprising the following steps:
1) get Radix Alangii medical material, select, be cut into long section, the long 15cm that is no more than;
2) prepare Sucus Glycyrrhizae: according to 1000 parts of clean medical materials of Radix Alangii, the ratio of 200 portions of Radix Glycyrrhizaes, takes Radix Glycyrrhizae, the Radix Glycyrrhizae weighing up is decocted 2 times, add 10 times of water gagings at every turn, decoct for the first time 2h, decoct for the second time 1h, decoct afterwards and filter, filtrate for later use;
3) according to 1000 parts of clean medical materials of Radix Alangii, the ratio of 500 portions of milk, adds step 2 by milk) in the Sucus Glycyrrhizae for preparing, add the Radix Alangii medical material after the cutting that step 1) obtains, add water and supply the volume of 14 times of amounts of clean medical material, decoct 2h, filter;
4) by the forced air drying at 45 ℃ ± 2 ℃ of Radix Alangii after boiling, to obtain final product.
2. the concocting method of Chinese medicine Radix Alangii as claimed in claim 1, is characterized in that: in step 1), Radix Alangii medical material is pressed the cutting of 5cm/ section.
3. the concocting method of Chinese medicine Radix Alangii as claimed in claim 1, is characterized in that: step 2), 3) in decoction process be specially: first " intense fire " boils to boiling, then " slow fire " decocts.
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