CN102579514A - Method for processing alangium platanifolium - Google Patents
Method for processing alangium platanifolium Download PDFInfo
- Publication number
- CN102579514A CN102579514A CN2011100201647A CN201110020164A CN102579514A CN 102579514 A CN102579514 A CN 102579514A CN 2011100201647 A CN2011100201647 A CN 2011100201647A CN 201110020164 A CN201110020164 A CN 201110020164A CN 102579514 A CN102579514 A CN 102579514A
- Authority
- CN
- China
- Prior art keywords
- radix alangii
- radix
- sample
- alangii
- medical material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention provides a method which is applicable to process alangium platanifolium, as for the alangium platanifolium, alkaloid is not only the active ingredient but also the toxic ingredient of the alangium platanifolium. Consequently, the research on the method for safely and reasonably processing the drug is very important to improve the clinic medication safety of the drug. The method for processing the alangium platanifolium is scientific and reasonable, has stable technological parameters, can effectively improve the safety of the alangium platanifolium to realize the purposes of toxicity reduction and efficacy enhancement, and benefits industrial production.
Description
Technical field
The present invention relates to a kind of concocting method of Chinese medicine, particularly a kind of concocting method that is applicable to the Chinese medicine Radix Alangii.
Background technology
Radix Alangii is dry radicula and the fibrous root of Alangiaceae plant Radix Alangii Alangium chinense (Lour.) Harms.Be distributed in ground such as Yunnan, Guizhou, for ethnic groups makes medication.Have dispelling wind and removing obstruction in the collateral, the effects such as silt analgesia, anesthesia and relaxed muscle of loosing are used to treat rheumatalgia, paralysis and numbness, heart failure, strain lumbago, traumatic injury etc.Its fibrous root and supporting root contain alkaloid, acids, aminoacid, organic acid, resin etc.Radix Alangii has wide research and development prospect because of advantages such as its curative effect are reliable, the medicine source is extensive, economy is convenient.
The Radix Alangii alkaloid mainly exists in radicula, fibrous root and the root bark, and wherein fibrous root content is the highest, and toxicity is also maximum.Modern pharmacological research shows: the effective ingredient of its myorelaxant effects is mainly alkaloid, but the toxicity of Radix Alangii mainly also comes from its contained alkaloid.The alkaloids composition is that the effective ingredient of Radix Alangii also is its toxic component.
Chinese Pharmacopoeia first one of version in 1977 write down the processing procedure of Chinese medicine Radix Alangii, and be specific as follows: remove impurity, clean, and vexed slightly, cutting, drying.This method is the conventional concocting method of Chinese medicine, and is not obvious to the Attenuation of medical material after concocting, and can not improve the drug safety of Radix Alangii.
Up to now, do not have still that a kind of can to stablize effective reduction Radix Alangii toxic, be convenient to the processing procedure of industrial applications.
Therefore, provide a kind of and be applicable to that the processing procedure that improves its safety of Radix Alangii is very necessary.
Summary of the invention
As far as the Chinese medicine Radix Alangii, contained alkaloid (mainly being anabasine) be its effective ingredient be again toxic component, and still do not have a kind of effectively concocting method of attenuation now.
To this problem, the invention provides a kind of concocting method that is applicable to Radix Alangii, this method is with respect to frying, for the yellow wine parch, can reaching attenuation effectively and significantly do not reduce the effect of drug effect, and processing procedure is scientific and reasonable, is convenient to suitability for industrialized production.
The concocting method of Radix Alangii provided by the invention, specific as follows:
1) gets the Radix Alangii medical material, select, be cut into long section, the long 15cm that is no more than;
2) preparation Sucus Glycyrrhizae: according to 1000 parts of clean medical materials of Radix Alangii, the ratio of 200 portions of Radix Glycyrrhizaes takes by weighing Radix Glycyrrhizae.The Radix Glycyrrhizae that weighs up is decocted 2 times, add 10 times of water gagings at every turn, decoct 2h for the first time, decoct 1h for the second time, fry in shallow oil the back and filter filtrate for later use;
3) according to 1000 parts of clean medical materials of Radix Alangii, the ratio of 500 portions of milk adds milk in the above-mentioned Sucus Glycyrrhizae for preparing, and adds the Radix Alangii medical material after the above-mentioned cutting, adds the volume that water complements to 14 times of amounts of clean medical material, decocts 2h, filters.
4) with Radix Alangii after the boiling in 45 ℃ ± 2 ℃ following forced air dryings, promptly get.
Processing procedure provided by the invention, its consumption proportion is following: the clean medical material of every 1000g, use Radix Glycyrrhizae 200g, milk 500g.
In the processing procedure step 1) provided by the invention, the Radix Alangii medical material is pressed the cutting of 5cm/ section more.
The related decoction process of processing procedure provided by the invention is specially: " intense fire " boils to boiling earlier, and " slow fire " decocts again.
As far as this concocting method, the Radix Glycyrrhizae sweet in the mouth, property is flat.Have invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain effect.Medicine can relax the property of medicine after Sucus Glycyrrhizae system, reduce toxicity.The record of Radix Glycyrrhizae " detoxifcation " is just arranged in Shennong's Herbal.The Radix Glycyrrhizae main component is glycyrrhizic acid and liquirtin, reducing sugar, starch and gelatin substance etc.The glucuronic acid that generates after the glycyrrhizic acid hydrolysis has Detoxication, and liquirtin is a surfactant simultaneously, can increase other water insoluble solubility of substances.Radix Glycyrrhizae commonly used is a guiding drug in the tcm prescription, and coordinating the actions of various ingredients in a prescription also plays solubilization in the process of preparing Chinese medicine and decoction process.
Milk: milk commonly used arrives the effect that relaxes the property of medicine, reduces toxicity, heightens the effect of a treatment as Auxiliary Liquid Material in the ethnic drug big gun.
The specific embodiment
Below in conjunction with the specific embodiment the present invention is further described in detail, the embodiment that provides has been merely and has illustrated the present invention, rather than in order to limit scope of the present invention.
Embodiment 1: the concocting method of Radix Alangii
This experiment provides the processing procedure under the various dose proportioning, and desire filters out the optimal processing parameter of Radix Alangii processing procedure from follow-up experiment.
Technology 1:
According to processing procedure step provided by the invention, according to per 1000 parts of Radix Alangii crude drugs, 100 portions of Radix Glycyrrhizaes, the proportioning of 250 portions of milk is concocted a collection of Radix Alangii, and concrete operations are following:
1) buys a collection of Radix Alangii medical material, select, be cut into long section, be about 5cm;
2) the Radix Alangii medical material after the above-mentioned cutting is weighed heavily about 2000g;
3) preparation Sucus Glycyrrhizae: take by weighing Radix Glycyrrhizae 200g, decoct 2 times, add water 2L at every turn, " intense fire " boils to boiling earlier, and " slow fire " decocts again.Decoct for the first time 2h, decoct 1h for the second time, fry in shallow oil the back and filter filtrate for later use;
4) the Radix Alangii medical material after above-mentioned the weighing is put into decoction pot, adds above-mentioned steps 3) in the Sucus Glycyrrhizae for preparing, add 500g milk again, adding water again, to complement to total decocting liquid volume be 28L, decocts 2h, filters;
5) with Radix Alangii after the boiling in 45 ℃ ± 2 ℃ following forced air dryings, promptly get.
Technology 2:
According to processing procedure step provided by the invention, according to per 1000 parts of Radix Alangii crude drugs, 200 portions of Radix Glycyrrhizaes, the proportioning of 500 portions of milk is concocted a collection of Radix Alangii, and concrete operations are following:
1) buys a collection of Radix Alangii medical material, select, be cut into long section, be about 5cm;
2) the Radix Alangii medical material after the above-mentioned cutting is weighed heavily about 2000g;
3) preparation Sucus Glycyrrhizae: take by weighing Radix Glycyrrhizae 400g, decoct 2 times, add water 4L at every turn, " intense fire " boils to boiling earlier, and " slow fire " decocts again.Decoct for the first time 2h, decoct 1h for the second time, fry in shallow oil the back and filter filtrate for later use;
4) the Radix Alangii medical material after above-mentioned the weighing is put into decoction pot, adds above-mentioned steps 3) in the Sucus Glycyrrhizae for preparing, add 1000g milk again, adding water again, to complement to total decocting liquid volume be 28L, decocts 2h, filters;
5) with Radix Alangii after the boiling in 45 ℃ ± 2 ℃ following forced air dryings, promptly get.
Technology 3:
According to processing procedure step provided by the invention, per 1000 parts of Radix Alangii crude drugs, 400 portions of Radix Glycyrrhizaes, the proportioning of 1000 portions of milk is concocted a collection of Radix Alangii, and concrete operations are following:
1) buys a collection of Radix Alangii medical material, select, be cut into long section, be about 5cm;
2) the Radix Alangii medical material after the above-mentioned cutting is weighed heavily about 2000g;
3) preparation Sucus Glycyrrhizae: take by weighing Radix Glycyrrhizae 800g, decoct 2 times, add water 8L at every turn, " intense fire " boils to boiling earlier, and " slow fire " decocts again.Decoct for the first time 2h, decoct 1h for the second time, fry in shallow oil the back and filter filtrate for later use;
4) the Radix Alangii medical material after above-mentioned the weighing is put into decoction pot, adds above-mentioned steps 3) in the Sucus Glycyrrhizae for preparing, add 2000g milk again, adding water again, to complement to total decocting liquid volume be 28L, decocts 2h, filters;
5) with Radix Alangii after the boiling in 45 ℃ ± 2 ℃ following forced air dryings, promptly get.
Embodiment 2:
Different concocting methods are concocted the comparative study of back Radix Alangii acute toxicity and the effect of flesh pine
1 experiment material
1.1 experiment medicine
No. 1 sample: the Radix Alangii medical material is given birth to article (not concocting), and amounting to the crude drug amount is 1.08g/g, lot number: SP001.
No. 2 samples: medicine after the parch of Radix Alangii medical material yellow wine (it is clear-cut that every 1000g crude drug adding 100g yellow wine is fried to sample), amounting to the crude drug amount is 1.25g/g, lot number: PZP001.
No. 3 samples: the Radix Alangii medical material is fried back medicine (it is clear-cut to fry to sample), and amounting to the crude drug amount is 1.30g/g, lot number: PZP002.
No. 4 samples: medicine after the boiling of Radix Alangii medical material Radix Glycyrrhizae milk (concocting by the technology that provides among the embodiment 1 1), amounting to the crude drug amount is 1.14g/g, lot number: PZP003.
No. 5 samples: medicine after the boiling of Radix Alangii medical material Radix Glycyrrhizae milk (concocting by the technology that provides among the embodiment 1 2), amounting to the crude drug amount is 1.18g/g, lot number: PZP004.
No. 6 samples: medicine after the boiling of Radix Alangii medical material Radix Glycyrrhizae milk (concocting by the technology that provides among the embodiment 1 3), amounting to the crude drug amount is 1.26g/g, lot number: PZP005.
Above medicine provides by the Beijing ChuangLi KeChuang Medicine Technology Development Co., Ltd.It is subsequent use all to be made into the suspension of suitable concentration with 0.5%CMC-Na before the test.
1.2 laboratory animal
Kunming kind white mice, body weight 19-21g or 20-22g, male and female half and half, available from Changchun Biological Products Institute, the mice quality certification number: 2006-0001.
2 experimental techniques and result
2.1 different concocting methods are to the influence of Radix Alangii sample LD50
Get 420 of above-mentioned mices, be divided into 6 groups at random, 70 every group, fasting can't help water and is irritated the Radix Alangii sample suspension after stomach gives the distinct methods process of preparing Chinese medicine after 16 hours respectively, irritates stomach once, and volume is 40ml/kg.Diet, activity, feces, body weight, fur glossiness and the living or death situation of two all interior animals after the observation administration; Observe nose, eye, oral cavity simultaneously and have or not the abnormal secretion thing; And dead animal in time dissected the pathological change situation of main organs such as the perusal heart, liver, spleen, lung, kidney.Adopt " Bliss method " to calculate 6 sample LD50, the result sees table 1.
The different concocting methods of table 1 are to the influence of Radix Alangii sample LD50
(annotate: ▲ representative is compared P＜0.05 with No. 1 sample)
Can know that by table 1 most animals begins to occur poisoning symptom and dead successively after administration in 3-20 minute: at first animal show as quiet few moving, rapid breathing then, on one's deathbed before general tremor, struggling holds down, the individual animal hind leg is stiff.Surviving animals is basic after about 40 minutes recovers normal.Dead animal is in time dissected, and the perusal heart, liver, spleen, lung, kidney are not all seen obvious abnormal change.
No. 1 sample animal dead percentage rate is respectively 100%, 70%, 70%, 50%, 40%, 20%, 10%, and LD50 is 3.0433g/kg (amounting to the crude drug amount is 3.2868g/kg).
No. 2 sample animal dead percentage rate is respectively 90%, 80%, 70%, 50%, 10%, 10%, and LD50 is 3.1026g/kg (amounting to the crude drug amount is 3.8782g/kg).
No. 3 sample animal dead percentage rate is respectively 100%, 100%, 60%, 50%, 40%, 30%, 0%, and LD50 is 2.8481g/kg (amounting to the crude drug amount is 3.7025g/kg).
No. 4 sample animal dead percentage rate is respectively 90%, 80%, 70%, 60%, 40%, 20%, 0%, and LD50 is 4.2631g/kg (amounting to the crude drug amount is 5.0412g/kg).
No. 5 sample animal dead percentage rate is respectively 90%, 80%, 60%, 50%, 40%, 20%, 10%, 0%, and LD50 is 4.4102g/kg (amounting to the crude drug amount is 5.2040g/kg).
No. 6 sample animal dead percentage rate is respectively 90%, 80%, 70%, 50%, 30%, 20%, 20%, 0%, and LD50 is 4.1728g/kg (amounting to the crude drug amount is 4.9762g/kg).
6 sample toxicity size orders are followed successively by: No. 1 sample＞No. 3 sample＞No. 2 sample＞No. 6 sample＞No. 4 sample＞No. 5 samples.It is thus clear that; Above-mentioned concocting method all has certain Attenuation to the Radix Alangii medical material, and with 4,5, No. 6 sample Attenuations the most obviously (P＜0.05), No. 5 samples relative No. 4 with No. 6 samples; Attenuation is better; But difference is not remarkable, explains that concocting method provided by the invention is the strongest to the Attenuation of Radix Alangii, and the Radix Alangii Attenuation of wherein concocting with the processing procedure parameter of No. 5 samples is best.
2.2 different concocting methods are to the influence of Radix Alangii sample ED50
The influence of the different concocting methods of " climbing the net method " test to the flesh pine effect of Radix Alangii adopted in this experiment, and specific as follows: wire gauze and desktop are 60 ° of angles, and mice is put on the net, let alone to seek connections with and creep, and observe 60 minutes, and it is qualified not falling the person.
Qualified mice (240 are divided into 6 groups, 40 the every group at random) fasting of screening can't help water 16 hours, irritate stomach respectively and give the Radix Alangii sample suspension after distinct methods is concocted, irritate stomach once, volume is 40ml/kg.After the administration mice is put on the wire gauze, lets alone to seek connections with and creep, observe in 60 minutes and fall situation voluntarily.Voluntarily do not fall the person, it is put back on the net, continuous 3 persons of falling are positive, represent that it is the effect of flesh pine that this medicine has the extremity myoparalysis.Adopt " Bliss method " to calculate 6 sample ED50.The result is as shown in table 2.
The different concocting methods of table 2 are to the influence of Radix Alangii sample ED50
(annotate: ▲ representative is compared P＜0.05 with No. 1 sample)
Can be known that by table 2 No. 1 sample animal falls percentage rate and is respectively 90%, 90%, 70%, 60%, 60%, 20%, 10%, 0%, ED50 is 1.2892g/kg (amounting to the crude drug amount is 1.3957g/kg).
No. 2 sample animals fall percentage rate and are respectively 100%, 80%, 50%, 40%, 20%, 0%, and ED50 is 1.3241g/kg (amounting to the crude drug amount is 1.7211g/kg).
No. 3 sample animals fall percentage rate and are respectively 90%, 70%, 60%, 50%, 20%, 10%, 0%, and ED50 is 2.0321g/kg (amounting to the crude drug amount is 2.4009g/kg).
No. 4 sample animals fall percentage rate and are respectively 100%, 80%, 60%, 40%, 20%, 10%, 0%, and ED50 is 1.3074g/kg (amounting to the crude drug amount is 1.5427g/kg).
No. 5 sample animals fall percentage rate and are respectively 90%, 80%, 60%, 40%, 20%, 10%, 0%, and ED50 is 1.2791g/kg (amounting to the crude drug amount is 1.4862g/kg).
No. 6 sample animals fall percentage rate and are respectively 100%, 90%, 60%, 40%, 20%, 20%, 0%, and ED50 is 1.3237g/kg (amounting to the crude drug amount is 1.6209g/kg).
ED50 by big extremely little order is: No. 3 sample＞No. 2 sample＞No. 6 sample＞No. 4 sample＞No. 5 sample＞No. 1 samples.It is thus clear that the flesh pine effect of 4,5, No. 6 samples is not compared with No. 1 sample and significantly reduced, this result shows the Radix Alangii that utilizes after concocting method provided by the invention is concocted under the significantly reduced situation of toxicity, and drug effect does not significantly reduce.
2.3 different concocting methods are to the Radix Alangii Influence on security
According to formula: therapeutic index (TI)=LD50/ED50, calculate TI, relatively size is estimated different concocting method Herba Astragali Bhotanensis maple Influence on security with this, and the result is as shown in table 3.
The different concocting methods of table 3 are to the Radix Alangii Influence on security
Can know that by table 3 therapeutic index TI is followed successively by by big extremely little order: No. 5 sample＞No. 4 samples＞No. 1 sample＞No. 3 sample of No. 6 sample＞No. 2 sample ≌.Because therapeutic index is big more, its safety is high more, otherwise then low more.Therefore, No. 3 minimums of 6 secure sample property of Radix Alangii, 1, No. 2 sample takes second place, and 4,5, No. 6 sample is better, and wherein No. 5 secure sample property are the highest.This result shows the concocting method of utilizing Radix Alangii provided by the invention than other method, and the safety of concocting the back Radix Alangii is best.
3 experiment conclusion
Radix Alangii supporting root and root bark contain alkaloid, acids, aminoacid, organic acid, resin; Fibrous root mainly contains alkaloid and glucosides and cardiac glycoside.The Radix Alangii alkaloid mainly exists in radicula, fibrous root and the root bark, and wherein fibrous root content is the highest, and toxicity is also maximum.Modern pharmacological research shows: the effective ingredient of its myorelaxant effects is mainly alkaloid, but the toxicity of Radix Alangii mainly also comes from its contained alkaloid.The alkaloids composition is that the effective ingredient of Radix Alangii also is its toxic component.
For reaching the purpose of clinical practice attenuation synergistic, the present invention adopts 3 kinds of distinct methods to crude drug, and wherein three of a kind of method different technical parameters are concocted.And, carried out comparative study to its LD50 and ED50 that concocts 6 samples in front and back, calculate TI simultaneously.Experimental result shows that 6 sample LD50 of Radix Alangii size order is followed successively by sample＞No. 3 sample＞No. 2 sample＞No. 6 sample＞No. 4 sample＞No. 5 samples No. 1.It is thus clear that the Radix Alangii medical material has all reached certain Attenuation after concocting, and the most obvious with No. 5 sample Attenuations especially; 6 sample ED50 by big extremely little order are: No. 3 sample＞No. 2 sample＞No. 6 sample＞No. 4 sample＞No. 5 sample＞No. 1 samples.It is thus clear that 4,5, No. 6 samples are under the situation of attenuation, its flesh pine effect does not significantly reduce; The TI value of 6 samples, No. 3 sample minimums, 1, No. 2 sample takes second place, and 4,5, No. 6 sample is better.Because therapeutic index is big more, its safety is high more, otherwise then low more.Therefore, No. 5 secure sample property are best.
To sum up visible, in 6 samples of Radix Alangii, No. 5 sample Attenuations after utilizing method provided by the invention to concoct are best, comprehensive safety property is best, the purpose of attenuation behind the medicinal material processing that has reached basically, and it is concocted back drug effect and significantly reduces.
The stability test of embodiment 3 processing procedures of the present invention
3.1 for stability and the feasibility of verifying processing procedure provided by the invention, the present invention has accomplished the pilot scale Research of amplified of the Radix Alangii in 10 batches in 3 places of production, and each lot sample article is detected, the result is as shown in table 4.
10 batches of pilot scale amplification datas of table 4
3.2
The different places of production of table 5 Radix Alangii gives birth to article and processed product anabasine assay result
3.3 study on the stability research
The present invention has carried out stability study at ambient temperature to 3 batches of pilot products of quantity-produced, has accomplished 12 months stability study work at present, and the result sees table 6-8.The result shows that these article quality under this packing and condition of storage is basicly stable.
Table 6 system Radix Alangii long-term stable experiment is table as a result
The name of an article: system Radix Alangii lot number: 20090601 dates of manufacture: in June, 2009
Table 7 system Radix Alangii long-term stable experiment is table as a result
The name of an article: system Radix Alangii lot number: 20090602 dates of manufacture: 2009
June in year
Table 8 system Radix Alangii long-term stable experiment is table as a result
The name of an article: system Radix Alangii lot number: 20090603 dates of manufacture: 2009
June in year
Claims (3)
1. the concocting method of a Chinese medicine Radix Alangii is characterized in that may further comprise the steps:
1) gets the Radix Alangii medical material, select, be cut into long section, the long 15cm that is no more than;
2) preparation Sucus Glycyrrhizae: according to 1000 parts of clean medical materials of Radix Alangii, the ratio of 200 portions of Radix Glycyrrhizaes takes by weighing Radix Glycyrrhizae.The Radix Glycyrrhizae that weighs up is decocted 2 times, add 10 times of water gagings at every turn, decoct 2h for the first time, decoct 1h for the second time, fry in shallow oil the back and filter filtrate for later use;
3) according to 1000 parts of clean medical materials of Radix Alangii, the ratio of 500 portions of milk adds milk in the above-mentioned Sucus Glycyrrhizae for preparing, and adds the Radix Alangii medical material after the above-mentioned cutting, adds the volume that water is supplied 14 times of amounts of clean medical material, decocts 2h, filters.
4) with Radix Alangii after the boiling in 45 ℃ ± 2 ℃ following forced air dryings, promptly get.
2. the processing procedure of a Chinese medicine Radix Alangii, it is characterized in that: in the step 1), the Radix Alangii medical material is pressed the cutting of 5cm/ section.
3. the processing procedure of a Chinese medicine Radix Alangii, it is characterized in that: the decoction process that relates to is specially: " intense fire " boils to boiling earlier, and " slow fire " decocts again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110020164.7A CN102579514B (en) | 2011-01-18 | 2011-01-18 | Method for processing alangium platanifolium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110020164.7A CN102579514B (en) | 2011-01-18 | 2011-01-18 | Method for processing alangium platanifolium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102579514A true CN102579514A (en) | 2012-07-18 |
| CN102579514B CN102579514B (en) | 2014-05-28 |
Family
ID=46469119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110020164.7A Active CN102579514B (en) | 2011-01-18 | 2011-01-18 | Method for processing alangium platanifolium |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102579514B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104997822A (en) * | 2015-07-29 | 2015-10-28 | 安徽国顺中药发展有限公司 | Processing method of radix glehniae |
| CN105012802A (en) * | 2015-07-29 | 2015-11-04 | 安徽国顺中药发展有限公司 | Processing method of rhizoma smilacis glabrae |
| CN105012694A (en) * | 2015-07-29 | 2015-11-04 | 安徽国顺中药发展有限公司 | Method for preparing edible tulip |
| CN105125602A (en) * | 2015-07-29 | 2015-12-09 | 安徽国顺中药发展有限公司 | Radix cyathulae preparation method |
| CN110521905A (en) * | 2019-08-21 | 2019-12-03 | 贵州仙草生物科技有限公司 | Golden hairpin dendrobium extract and preparation method thereof and HERBA DENDROBII solid beverage |
-
2011
- 2011-01-18 CN CN201110020164.7A patent/CN102579514B/en active Active
Non-Patent Citations (6)
| Title |
|---|
| 《安徽省中药饮片炮制规范》 20060131 安徽省食品药品监督管理局 八角枫根 102-103 2 , * |
| 吴一飞等: "八角枫药学研究概况", 《安徽农业科学》 * |
| 安徽省食品药品监督管理局: "《安徽省中药饮片炮制规范》", 31 January 2006 * |
| 宋宏春等: "不同炮制方法对蒙药泡囊草中托烷类生物碱含量的影响", 《中国民族医药杂志》 * |
| 蒋媛媛等: "中药八角枫生药学的初步研究", 《广东药学》 * |
| 钮正睿等: "炮制辅料甘草汁的制备工艺研究", 《中国中药杂志》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104997822A (en) * | 2015-07-29 | 2015-10-28 | 安徽国顺中药发展有限公司 | Processing method of radix glehniae |
| CN105012802A (en) * | 2015-07-29 | 2015-11-04 | 安徽国顺中药发展有限公司 | Processing method of rhizoma smilacis glabrae |
| CN105012694A (en) * | 2015-07-29 | 2015-11-04 | 安徽国顺中药发展有限公司 | Method for preparing edible tulip |
| CN105125602A (en) * | 2015-07-29 | 2015-12-09 | 安徽国顺中药发展有限公司 | Radix cyathulae preparation method |
| CN110521905A (en) * | 2019-08-21 | 2019-12-03 | 贵州仙草生物科技有限公司 | Golden hairpin dendrobium extract and preparation method thereof and HERBA DENDROBII solid beverage |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102579514B (en) | 2014-05-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103355555A (en) | Feed for laying hen in egg-laying peak stage and preparation method thereof | |
| CN104398986A (en) | Tranquilization and brain tonifying epimedium herb oral liquid and preparation method thereof | |
| CN103859375A (en) | Formula and preparation method of life cultivation and health preservation food helpful for enhancing immunity | |
| CN102579514B (en) | Method for processing alangium platanifolium | |
| CN106038670A (en) | Preparation method of Vaccinium dunalianum Wight extract | |
| CN101234164A (en) | Pharmaceutical combination for improving skin oil-water balance and acne symptom and preparation thereof | |
| CN103637179B (en) | Food composition with functions of lowering blood sugar and blood fat and improving fatty liver | |
| CN106177053A (en) | A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja and Pericarpium Citri Reticulatae | |
| CN105497261A (en) | Matrix of patch for external use and patch and sleeping-aid patch made from matrix | |
| CN105664140A (en) | Glycopeptide composition as well as preparation method and application thereof | |
| CN101972334B (en) | Traditional Chinese medicine preparation for preventing and treating infantile eczema and preparation method thereof | |
| CN104489172A (en) | Acanthopanax health tea for improving immunity and preparation method thereof | |
| CN104206595A (en) | Blood lipid and blood glucose reducing Chinese wolfberry root-bark health care tea and preparation method thereof | |
| CN102302114A (en) | Pollen-containing health-care food and preparation method thereof | |
| CN104397282A (en) | Tranquilization and brain tonifying eleutherococcus senticosus healthare tea and preparation method thereof | |
| CN101485716B (en) | Medicament for treating radiation injury and preparation method thereof | |
| CN104940516B (en) | A kind of Chinese medicine composition for treating chronic aplastic anemia and preparation method and application | |
| CN106942659B (en) | Preparation method of health-care momordica charantia buccal tablets | |
| CN105194352B (en) | A kind of Chinese medicine composition and preparation method thereof improving learning and memory | |
| CN103520684A (en) | Traditional Chinese medicine compound for reducing blood sugar | |
| CN103239673B (en) | Traditional Chinese medicine composition for preventing and curing sudden death syndrome of cow | |
| CN108721607A (en) | A kind of collagen-rich anti-senility oral liquid and preparation method thereof | |
| CN106728392B (en) | Traditional Chinese medicine for treating liver-stagnation and spleen-deficiency type impotence and preparation method thereof | |
| CN106728828A (en) | A kind of Chinese medicine preparation and its preparation technology for treating coronary heart disease | |
| Kim et al. | Study of efficacy and safety of ginseng seed oil in heathy subjects who have mild liver dysfunction: a randomized, double blinded, placebo-controlled study |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |