CN103751692B - Special invigorating capsule of a kind of Testis et penis callorhini and preparation method thereof - Google Patents
Special invigorating capsule of a kind of Testis et penis callorhini and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of capsule utilizing the Chinese crude drug such as Testis et penis callorhini and Herba Epimedii to make and preparation method thereof.The raw material of capsule consists of: Testis et penis callorhini 1-7 part, Herba Epimedii 50-120 part, Radix Ginseng 10-70 part, Fructus Amomi 15-60 part, Flos Carthami 10-110 part, Fructus Jujubae 10-110 part, Poria 50-120 part, Rhizoma Dioscoreae 50-120 part, Fructus Lycii 50-120 part, Cortex Cinnamomi 10-70 part, Cortex Eucommiae 20-70 part, Fructus Schisandrae Chinensis 10-60 part, Herba Cistanches 20-60 part.Preparation method of the present invention adopts different processing methods for crude drug different qualities, takes full advantage of active substance wherein, and method is practical.This product has warming and recuperating the kidney-YANG, enriching yin and nourishing kidney, effect of resisting fatigue, slow down aging, and for physical fatigue, the whole body is weak, and the head is dim-sighted, and sexual disorder etc. have good opsonic action.
Description
Technical field
The present invention relates to health product and manufacturing technology field thereof, be specifically related to special invigorating capsule of a kind of Testis et penis callorhini and preparation method thereof.
Background technology
The symptoms such as the increasing people of China occurs that kidney is short of power, overtired, senilism, body constitution declines, and as everyone knows, and kidney is our human body vitals, regulates water, electrolyte balance; Regulate environment acid-base balance; Discharge metabolic waste; Secretion feritin, promotes blood pressure; Secretion erythropoietin, prevents anemia etc.
Testis et penis callorhini, Chinese medicine name: Testis et penis callorhini (different name: the penis and tester of an ursine seal), all on the books in " Bencao Tujing ", " Haiyao Bencao, Oversea Materia Medica " and Compendium of Material Medica.Testis et penis callorhini is flat, gentleness is not dry, takes and does not get angry, be rich in kidney power active factors, 18 seed amino acids of multiple peptide matters, needed by human; Have multiple unsaturated fatty acid (EPA, DPA, DHA) and the effective ingredient such as nucleic acid, nucleotide.Testis et penis callorhini belongs to the in love product of flesh and blood, and effective ingredient contained by it is combination form, be easy to absorption of human body can tonifying YANG YIN nourishing, kidney tonifying nourishing the liver, bone and muscle strengthening, endocrine regulation blood yiqi, be applicable to the weak patient of blood deficiency gas.Skin care skin Caring.There is slow down aging, keep the effect of elasticity of skin and moisture.
Disclosed kidney-tonifying heath nutriment is a lot of at present, also has some to adopt Testis et penis callorhini to be raw material.Such as publication number is CN1378845A, and publication date is that the Chinese patent on November 13rd, 2002 discloses a kind of Ursine seal penis capsule, but its composition is only Testis et penis callorhini, and component is single, and effect is single; Notification number is CN101182449B, and the Chinese patent in May 25 2011 day for announcing discloses a kind of tortoise penis kidney-tonifying wine, and containing raw materials such as Testis et penis callorhinis, the program is just by simply alcohol-pickled, low to utilization rate of active components in medicine.Sum up existing the kidney invigorating product, there are the following problems: the effect of the kidney invigorating on the one hand haves much room for improvement; Can bring side effect to human body on the other hand while the kidney invigorating, threaten health, these are determined by its formula.In addition, in traditional health product production process, also also exist technological deficiency as: utilization rate of active components is low; Introduce harmful chemical agents; When taking, the efficacy of a drug easily loses; Easily damage etc. is caused to gastrointestinal tract.
Summary of the invention
The object of the invention is: provide a kind of and have good warming and recuperating the kidney-YANG, enriching yin and nourishing kidney, resisting fatigue, slow down aging effect, the capsule little to human body side effect, and a kind of utilization rate of active components is high, the preparation method of the health-caring capsule of green safety.
The special invigorating capsule of a kind of Testis et penis callorhini, the raw material of its effective ingredient consists of: Testis et penis callorhini 1-7 part, Herba Epimedii 50-120g, Radix Ginseng 10-70 part, Fructus Amomi 15-60 part, Flos Carthami 10-110 part, Fructus Jujubae 10-110 part, Poria 50-120 part, Rhizoma Dioscoreae 50-120 part, Fructus Lycii 50-120 part, Cortex Cinnamomi 10-70 part, Cortex Eucommiae 20-70 part, Fructus Schisandrae Chinensis 10-60 part, Herba Cistanches 20-60 part.
The special invigorating capsule of described Testis et penis callorhini, the raw material composition of its effective ingredient is preferably: Testis et penis callorhini 2-6 part, Herba Epimedii 55-110 part, Radix Ginseng 15-60 part, Fructus Amomi 20-55 part, Flos Carthami 15-100 part, Fructus Jujubae 15-100 part, Poria 55-120 part, Rhizoma Dioscoreae 55-120 part, Fructus Lycii 55-120 part, Cortex Cinnamomi 15-65 part, Cortex Eucommiae 25-65 part, Fructus Schisandrae Chinensis 15-57 part, Herba Cistanches 25-55 part.
In the special invigorating capsule formula of above-mentioned Testis et penis callorhini, the medical material adopted is all adopt first-class medical material, and the effective ingredient in medicine is more obvious than the effect of other medical materials, can produce adverse influence when active constituent content is not high to drug effect.
Testis et penis callorhini has another name called Testis et penis callorhini.Effect: tonifying YANG YIN nourishing, kidney-supplementing liver-boosting, blood yiqi, skin care skin Caring, bone and muscle strengthening.Cure mainly: impotence in male, woman's deficiency and coldness leucorrhea, fails to be impregnated for a long time.
Herba Epimedii has another name called Herba Epimedii.Effect: reinforcing the kidney and supporting YANG.Wind-damp dispelling.Cure mainly: impotence due to deficiency of the kidney, arthralgia due to cold-dampnes or numb limbs and tense tendons etc.
Cortex Cinnamomi effect: warming middle-JIAO YANG invigorating, dispersing cold for relieving pain.Cure mainly: deficiency of spleen-YANG and kidneyYANG, anosis weak, arthralgia due to cold lumbago etc.
Radix Ginseng effect: strongly invigorating primordial QI, tonifying the lung strengthening the spleen.Promote the production of body fluid, calm the nerves.Cure mainly: the deficiency of vital energy is for de-.The deficiency of the lung is panted, weakness of the spleen and stomach.Chronic diarrhea proctoptosis, quenches one's thirst, malaise etc.
Fructus Amomi effect: removing dampness is amusing, antiabortive.Cure mainly: stagnation of QI in spleen and stomach, stomachache is had loose bowels, frequent fetal movement etc.
Flos Carthami effect: activating blood circulation to dissipate blood stasis, improves body microcirculation.Cure mainly: the stasis of blood is only had a pain, joint aches, blood stops amenorrhea etc.
Fructus Jujubae effect: tonifying the spleen and stomach, nutrition is calmed the nerves, and relaxes the property of medicine.Cure mainly: weakness of the spleen and stomach, the deficiency of vital energy is not enough, lassitude etc.
Poria effect: diuretic dampness removing, spleen invigorating and in, mind tranquilizing and the heart calming.Cure mainly: dysuria, edema, lack of appetite gastral cavity is vexed, loose stool, palpitation and insomnia etc.
Rhizoma Dioscoreae effect: tonifying the spleen and stomach, lung benefiting kidney.Cure mainly: weakness of the spleen and stomach.Lack of appetite body is tired, chronic cough of deficiency lung, frequent micturition etc.
Fructus Lycii effect: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.Cure mainly: deficiency of the liver and kindey, seminal emission, has a dizzy spell.
Radix Astragali effect: the raw sun of QI invigorating, strengthening superficial resistance to stop perspiration, holder skin ulcer granulation promoting, diuresis detumescent.Cure mainly: the deficiency of vital energy is weak, lassitude, skin infection is burst for a long time and is not held back, edema etc.
Cortex Eucommiae effect: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Cure mainly: deficiency of the liver and kindey, sexual impotence, frequent micturition, anemia of pregnant woman's body is empty, liability to abortion etc.
Fructus Schisandrae Chinensis effect: nourishing kidney of astringing the lung, spermatogenesis arresting sweating.Cure mainly: chronic cough is panted, the empty hyperhidrosis of body, essence is sliding not solid, frequent micturition, incessant chronic diarrhea etc.
Herba Cistanches effect: nourishing kidney gas, replenishing vital essence and blood is not dry not warm for the agent temperature compensation of flat benefit.Cure mainly: some symptoms caused because suffering from a deficiency of the kidney.
Why the special invigorating capsule of Testis et penis callorhini of the present invention adopts above-mentioned formula, the medical material that main use is apt to the warming and recuperating the kidney-YANG such as superfine product Testis et penis callorhini, Herba Epimedii, Cortex Cinnamomi in the tonic of nourishing YIN the yang aspect of yang is principal agent, be aided with Radix Ginseng strongly invigorating primordial QI, invigorating the spleen to benefit the lung, Flos Carthami blood circulation promoting and blood stasis dispelling, Poria, Rhizoma Dioscoreae, Fructus Jujubae, Fructus Amomi invigorating the spleen and regulating the stomach, Fructus Lycii nourishing kidney yin.After composition of prescription, negative and positive can be made with mending, and Liver and kidney is complementary with benefit, QI and blood, reaches the effect of warming and recuperating the kidney-YANG, enriching yin and nourishing kidney, resisting fatigue, slow down aging.
The mechanism of effect:
(1) negative and positive are with mending: containing a large amount of property power active factors in Testis et penis callorhini, the energy of people, muscle power and mental can be improved, supplement the property power active factors lost in human body and carry out enhancing human body immunity power, reinforcing the kidney and supporting YANG, take into account nourishing kidney yin, across-the-board regulation human body yin-yang balancing, thus the object reaching diseases prevention health care.
(2) Liver and kidney is with mending: The liver and the kidney have a common source, blood stored in the liver, kidney storing essence, the raw gasification depending on essence in kidney of the change of blood, essence in kidney fill the nourishing that Sheng also depends on blood.Renal essence generating blood, blood generating essence, the effect that Liver and kidney plays with complementary energy.
(3) activating blood circulation to dissipate blood stasis: this product take Testis et penis callorhini as main material, is equipped with again the medical material of activating blood circulation to dissipate blood stasis in side, can kidney tonifying gas, warm waist knee joint, promoting blood circulation, promoting the circulation of QI to relieve pain.
The manufacture method of the special invigorating capsule of above-mentioned Testis et penis callorhini, comprises the steps:
(1) medical material is taken by weight, for subsequent use;
(2) Testis et penis callorhini is pulverized after vacuum drying at 30-60 DEG C, sieve, make fine powder for subsequent use;
(3) by after Radix Ginseng, Flos Carthami, Fructus Amomi mixing, pulverize, sieve, make fine powder for subsequent use;
(4) by after other residue medical material mixing such as Herba Epimedii, add water boil, after boiling, 2h filters, and obtains first time filtrate; Repeat to add water boil to above-mentioned medical material, after boiling, 2h filters, and obtains second time filtrate; Merge twice filtrate, by filtrate concentrating under reduced pressure, obtain concentrated solution I;
(5) in concentrated solution I, add 95% ethanol, limit edged stirs, and at 0 ~ 5 DEG C, cold preservation leaves standstill 24h, gets supernatant; The supernatant of taking-up is carried out second time concentrating under reduced pressure, and concentrate and become concentrated solution II, at 40-70 DEG C, vacuum drying is dry cream, pulverizes and sieves, and obtains fine powder for subsequent use;
(6) by filled capsules after the fine powder mix homogeneously that obtains in step (2), step (3) and step (5), the special invigorating capsule of Testis et penis callorhini is.
Use multiple medical material in the present invention, the characteristic according to different medical material processes, and ensures the maximum utilization of effective ingredient in each medical material.
Testis et penis callorhini has stronger toughness as animality medical material, need first to be dried process, and adopt 30-60 DEG C of vacuum drying to be because hot environment can destroy the nutritional labeling in Testis et penis callorhini, temperature is too low can extend the vacuum drying time again, dry standard is for controlling water content about 5%, sieve after drying and crushing, obtain fine powder.
In order to prevent the loss of effective ingredient, improving the utilization rate of effective ingredient in medicine, Radix Ginseng directly being pulverized and sieved powder process, and Flos Carthami, Fructus Amomi contain a large amount of volatile oil (effective ingredient) and lose for avoiding it, also take the mode of direct powder process.
Be water miscible medical material for main component, adopt decoction and alcohol sedimentation technique to extract effective ingredient wherein in step of the present invention (5), the suitable amount adding ethanol according to the different choice of medical material used, reaches best extraction effect.The mixed extract of the medical materials such as Herba Epimedii is obtained after water extract-alcohol precipitation extracts, dry, pulverize and sieve, obtain fine powder.
For keeping the even particle size be loaded in capsule, operation of sieving adopts 80-100 object sieve, and the powder particle after sieving is even, and good fluidity, is suitable for filled capsules, and loading amount is also stablized.For the ease of taking and having good therapeutic effect, capule size is 0.45 gram/.The present invention adopts conventional method to fill capsule.
In the water extract-alcohol precipitation operation of described step (5), the object adding alcohol to remove a part of impurity, in order to reach desirable impurity-eliminating effect, adds 1-4 times that alcohol quality is concentrated solution I quality.
In water extract-alcohol precipitation operation, concentration operation is the addition in order to reduce alcohol, if but medicinal liquid overrich, effective ingredient is easily wrapped in precipitation, so concentrate for twice in step (4) and (5), the density of concentrated solution controls respectively: concentrated solution I:1.12 ~ 1.14g/cm
3; Concentrated solution II:1.36 ~ 1.40g/cm
3.
The form why special invigorating capsule of this Testis et penis callorhini adopts medicated powder encapsulated, instead of adopting other dosage forms as forms such as tablet, powder, pills, its final purpose is exactly to ensure giving full play to of pharmaceutical efficacy, uses other dosage forms, the efficacy of a drug is is easily scattered and disappeared, and is just difficult to the effect playing expection.And this dosage form of the present invention, both enable medicine fully act on human body, the protection again owing to there being capsule, and be unlikely to cause damage to the intestines and stomach of human body, thus reach the optimum efficiency of formula.Utilize formula of the present invention take other dosage forms be not cannot, but the medicament of every other form is all remarkably productive not as capsule of the present invention.
The present invention has the effect strengthening kidney power, resisting fatigue, slow down aging, has to mend and not dry simultaneously, negative and positive with mending, Liver and kidney with mending, QI and blood is complementary, reaches warming and recuperating the kidney-YANG, enriching yin and nourishing kidney, the feature of blood circulation promoting and blood stasis dispelling.In practice to physical fatigue, energy is weak, the whole body is weak, the head is dim-sighted, sexual disorder etc. has good effect, and this formula for a product adopts natural Chinese medicines formula, containing chemical reagent, can not bring side effect, be easy to absorption of human body.Preparation method of the present invention is practical, can utilize the effective ingredient in medicine fully, reduces dose; adopt the form preparation of capsule; its drug effect can be kept for a long time when drug administration, due to the protection of capsule, human body the intestines and stomach can also be protected injury-free.
Detailed description of the invention
Embodiment 1
The medical material used in the present embodiment all adopts first-class medical material, and wherein Testis et penis callorhini is Canadian import Testis et penis callorhini.
The special invigorating capsule of a kind of Testis et penis callorhini, the raw material of its effective ingredient consists of: Testis et penis callorhini 1g, Herba Epimedii 50g, Radix Ginseng 10g, Fructus Amomi 15g, Flos Carthami 10g, Fructus Jujubae 10g, Poria 50g, Rhizoma Dioscoreae 50g, Fructus Lycii 50g, Cortex Cinnamomi 10g, Cortex Eucommiae 20g, Fructus Schisandrae Chinensis 10g, Herba Cistanches 20g.
Its preparation process is:
(1) take medical material by above-mentioned quality, get the raw materials ready;
(2) Testis et penis callorhini is pulverized after vacuum drying at 30 DEG C, cross 80 mesh sieves, make fine powder for subsequent use;
(3) Radix Ginseng, Flos Carthami, Fructus Amomi three taste medicine are pulverized, cross 80 mesh sieves, make fine powder for subsequent use;
(4) other medical materials of residue such as Herba Epimedii are added 2.2L water boil, 2h after boiling, filters, and obtains first time filtrate, again medical material is added 1.6L water to repeat to boil, 2h after boiling, filters, and obtains second time filtrate, merge twice filtrate, carry out conventional concentrating under reduced pressure operation to filtrate, obtain concentrated solution I, density is 1.14g/cm
3.
(5) concentrated solution I is placed in Alcohol-settling tank, add 95% ethanol inside, addition is 1 times amount of concentrated solution I quality, limit edged stirs, then cold preservation leaves standstill 24h at 0 ~ 5 DEG C, after precipitation is complete, open the supernatant outlet valve of Alcohol-settling tank, with self priming pump, supernatant is extracted out, because of the in-built float-ball type drain apparatus of tank, decline gradually with supernatant liquid level, ball float also declines with liquid level, treats that supernatant exhausts, because turbid liquid-tight degree is much larger than supernatant, ball float floats over precipitate surface and no longer declines, and drain apparatus stops fluid automatically.The supernatant of taking-up is carried out second time concentrating under reduced pressure, and concentrate and become concentrated solution II, density is 1.36g/cm
3, at 40 DEG C, vacuum drying is dry cream (water content is less than 5%), pulverizes and sieves, obtains fine powder for subsequent use;
(6) by filled capsules after the fine powder mix homogeneously that obtains in step (2), step (3) and step (5), the special invigorating capsule of Testis et penis callorhini is.
All the other operating procedures all adopt prior art, repeat no more.
Embodiment 2
The medical material used in the present embodiment all adopts first-class medical material, and wherein Testis et penis callorhini is Canadian import Testis et penis callorhini.
The special invigorating capsule of a kind of Testis et penis callorhini, the raw material of its effective ingredient consists of: Testis et penis callorhini 2g, Herba Epimedii 55g, Radix Ginseng 15g, Fructus Amomi 20g, Flos Carthami 15g, Fructus Jujubae 15g, Poria 55g, Rhizoma Dioscoreae 55g, Fructus Lycii 55g, Cortex Cinnamomi 15g, Cortex Eucommiae 25g, Fructus Schisandrae Chinensis 15g, Herba Cistanches 25g.
Its preparation process is:
(1) take medical material by above-mentioned quality, get the raw materials ready;
(2) Testis et penis callorhini is pulverized after vacuum drying at 40 DEG C, cross 80 mesh sieves, make fine powder for subsequent use;
(3) Radix Ginseng, Flos Carthami, Fructus Amomi three taste medicine are pulverized, cross 80 mesh sieves, make fine powder for subsequent use;
(4) other medical materials of residue such as Herba Epimedii are added 2.5L water boil, 2h after boiling, filters, and obtains first time filtrate, again medical material is added 1.9L water to repeat to boil, 2h after boiling, filters, and obtains second time filtrate, merge twice filtrate, carry out conventional concentrating under reduced pressure operation to filtrate, obtain concentrated solution I, density is 1.13g/cm
3;
(5) concentrated solution I is placed in Alcohol-settling tank, add 95% ethanol inside, addition is 2 times amount of concentrated solution I quality, limit edged stirs, then cold preservation leaves standstill 24h at 5 DEG C, after precipitation is complete, open the supernatant outlet valve of Alcohol-settling tank, with self priming pump, supernatant is extracted out, because of the in-built float-ball type drain apparatus of tank, decline gradually with supernatant liquid level, ball float also declines with liquid level, treats that supernatant exhausts, because turbid liquid-tight degree is much larger than supernatant, ball float floats over precipitate surface and no longer declines, and drain apparatus stops fluid automatically.The supernatant of taking-up is carried out second time concentrating under reduced pressure, and concentrate and become concentrated solution II, density is 1.37g/cm
3, at 50 DEG C, vacuum drying is dry cream (water content is less than 5%), pulverizes and sieves, obtains fine powder for subsequent use;
(6) by filled capsules after the fine powder mix homogeneously that obtains in step 2, step 3 and step 5, the special invigorating capsule of Testis et penis callorhini is.
All the other operating procedures all adopt prior art, repeat no more.
Embodiment 3
The medical material used in the present embodiment all adopts first-class medical material, and wherein Testis et penis callorhini is Canadian import Testis et penis callorhini.
The special invigorating capsule of a kind of Testis et penis callorhini, the raw material of its effective ingredient consists of: Testis et penis callorhini 4g, Herba Epimedii 85g, Radix Ginseng 40g, Fructus Amomi 40g, Flos Carthami 60g, Fructus Jujubae 60g, Poria 80g, Rhizoma Dioscoreae 80g, Fructus Lycii 80g, Cortex Cinnamomi 40g, Cortex Eucommiae 50g, Fructus Schisandrae Chinensis 40g, Herba Cistanches 40g.
Its preparation process is:
(1) take medical material by above-mentioned quality, get the raw materials ready;
(2) Testis et penis callorhini is pulverized after vacuum drying at 50 DEG C, cross 100 mesh sieves, make fine powder for subsequent use;
(3) Radix Ginseng, Flos Carthami, Fructus Amomi three taste medicine are pulverized, cross 100 mesh sieves, make fine powder for subsequent use;
(4) other medical materials of residue such as Herba Epimedii are added 4.4L water boil, 2h after boiling, filters, and obtains first time filtrate, again medical material is added 3.3L water to repeat to boil, 2h after boiling, filters, and obtains second time filtrate, merge twice filtrate, carry out conventional concentrating under reduced pressure operation to filtrate, obtain concentrated solution I, density is 1.13g/cm
3;
(5) concentrated solution I is placed in Alcohol-settling tank, add 95% ethanol inside, addition is 3 times amount of concentrated solution I quality, limit edged stirs, then cold preservation leaves standstill 24h at 0 ~ 5 DEG C, after precipitation is complete, open the supernatant outlet valve of Alcohol-settling tank, with self priming pump, supernatant is extracted out, because of the in-built float-ball type drain apparatus of tank, decline gradually with supernatant liquid level, ball float also declines with liquid level, treats that supernatant exhausts, because turbid liquid-tight degree is much larger than supernatant, ball float floats over precipitate surface and no longer declines, and drain apparatus stops fluid automatically.The supernatant of taking-up is carried out second time concentrating under reduced pressure, and concentrate and become concentrated solution II, density is 1.36g/cm
3, at 60 DEG C, vacuum drying is dry cream (water content is less than 5%), pulverizes and sieves, obtains fine powder for subsequent use;
(6) by filled capsules after the fine powder mix homogeneously that obtains in step 2, step 3 and step 5, the special invigorating capsule of Testis et penis callorhini is.
All the other operating procedures all adopt prior art, repeat no more.
Embodiment 4
The medical material used in the present embodiment all adopts first-class medical material, and wherein Testis et penis callorhini is Canadian import Testis et penis callorhini.
The special invigorating capsule of a kind of Testis et penis callorhini, the raw material of its effective ingredient consists of: Testis et penis callorhini 6g, Herba Epimedii 110g, Radix Ginseng 60g, Fructus Amomi 55g, Flos Carthami 100g, Fructus Jujubae 100g, Poria 100g, Rhizoma Dioscoreae 100g, Fructus Lycii 100g, Cortex Cinnamomi 65g, Cortex Eucommiae 65g, Fructus Schisandrae Chinensis 57g, Herba Cistanches 55g.
Its preparation process is:
(1) take medical material by above-mentioned quality, get the raw materials ready;
(2) Testis et penis callorhini is pulverized after vacuum drying at 60 DEG C, cross 100 mesh sieves, make fine powder for subsequent use;
(3) Radix Ginseng, Flos Carthami, Fructus Amomi three taste medicine are pulverized, cross 100 mesh sieves, make fine powder for subsequent use;
(4) other medical materials of residue such as Herba Epimedii are added 6.0L water boil, 2h after boiling, filters, and obtains first time filtrate, again medical material is added 4.5L water to repeat to boil, 2h after boiling, filters, and obtains second time filtrate, merge twice filtrate, carry out conventional concentrating under reduced pressure operation to filtrate, obtain concentrated solution I, density is 1.12g/cm
3;
(5) concentrated solution I is placed in Alcohol-settling tank, add 95% ethanol inside, addition is 3 times amount of concentrated solution I quality, limit edged stirs, then cold preservation leaves standstill 24h at 0 DEG C, after precipitation is complete, open the supernatant outlet valve of Alcohol-settling tank, with self priming pump, supernatant is extracted out, because of the in-built float-ball type drain apparatus of tank, decline gradually with supernatant liquid level, ball float also declines with liquid level, treats that supernatant exhausts, because turbid liquid-tight degree is much larger than supernatant, ball float floats over precipitate surface and no longer declines, and drain apparatus stops fluid automatically.The supernatant of taking-up is carried out second time concentrating under reduced pressure, is condensed into concentrated solution II, density is 1.40g/cm
3, at 70 DEG C, vacuum drying is dry cream (water content is less than 5%), pulverizes and sieves, obtains fine powder for subsequent use;
(6) by filled capsules after the fine powder mix homogeneously that obtains in step 2, step 3 and step 5.
All the other operating procedures all adopt prior art, repeat no more.
Embodiment 5
The medical material used in the present embodiment all adopts first-class medical material, and wherein Testis et penis callorhini is Canadian import Testis et penis callorhini.
The special invigorating capsule of a kind of Testis et penis callorhini, the raw material of its effective ingredient consists of: Testis et penis callorhini 7g, Herba Epimedii 120g, Radix Ginseng 70g, Fructus Amomi 60g, Flos Carthami 110g, Fructus Jujubae 110g, Poria 120g, Rhizoma Dioscoreae 120g, Fructus Lycii 120g, Cortex Cinnamomi 70g, Cortex Eucommiae 70g, Fructus Schisandrae Chinensis 60g, Herba Cistanches 60g.
Its preparation process is:
(1) take medical material by above-mentioned quality, get the raw materials ready;
(2) Testis et penis callorhini is pulverized after vacuum drying at 60 DEG C, cross 100 mesh sieves, make fine powder for subsequent use;
(3) Radix Ginseng, Flos Carthami, Fructus Amomi three taste medicine are pulverized, cross 100 mesh sieves, make fine powder for subsequent use;
(4) other medical materials of residue such as Herba Epimedii are added 6.8L water boil, 2h after boiling, filters, and obtains first time filtrate, again medical material is added 5.1L water to repeat to boil, 2h after boiling, filters, and obtains second time filtrate, merge twice filtrate, carry out general concentrating under reduced pressure operation to filtrate, obtain concentrated solution I, density is 1.13g/cm3.
(5) concentrated solution I is placed in Alcohol-settling tank, add ethanol inside, addition is 4 times amount of concentrated solution I quality, limit edged stirs, then cold preservation leaves standstill 24h at 2 DEG C, after precipitation is complete, open the supernatant outlet valve of Alcohol-settling tank, with self priming pump, supernatant is extracted out, because of the in-built float-ball type drain apparatus of tank, decline gradually with supernatant liquid level, ball float also declines with liquid level, treats that supernatant exhausts, because turbid liquid-tight degree is much larger than supernatant, ball float floats over precipitate surface and no longer declines, and drain apparatus stops fluid automatically.Now can open slag notch, precipitate is discharged.Different according to the different deposit of material, first can open bottom butterfly valve and solvent or diluent is released.Get supernatant, the supernatant of taking-up is carried out second time concentrating under reduced pressure, concentrate and become concentrated solution II, density is 1.39g/cm3, and at 70 DEG C, vacuum drying is dry cream (water content is less than 5%), pulverizes and sieves, obtains fine powder for subsequent use;
(6) by filled capsules after the fine powder mix homogeneously that obtains in step 2, step 3 and step 5.
All the other operating procedures all adopt prior art, repeat no more.
Experimental example 1
Zoopery, tests the slow down aging effect of this product.
1. experiment material: Drosophila melanogaster: draw from environmental mutagenesis research department of Shanghai The 2nd Army Medical College; The special invigorating capsule of the Testis et penis callorhini using embodiment 3 to prepare.
2. experimental technique: by fly blow at 25 DEG C, 65% regulation of relative humidity incubator is hatched, the adult sprouted wings in 10 hours is anaesthetized with ether steam, male and female are distinguished under anatomical lens, 1600 are selected to be in charge of cultivation, then 4 groups are divided at random, often organize 400, male and female half and half, wherein blank group is cultivated with basis and is fed, other three groups is experimental group, 0.2wt% is added respectively in basal medium, 1wt%, the special invigorating capsule powder of 5wt% Testis et penis callorhini, every day more renews culture medium, observe fruit bat, male 52 days, female 60 days survival rates, and calculate average life and maximum life span.Result: refer to table 2.
Table 2 drosophila survival experiment
*p<0.05 is compared with matched group
*p<0.01 is compared with matched group
Through statistical analysis, 0.2% experimental group compares with matched group, and P<0.05 has notable difference, and 1% has significant differences with 5% experimental group P<0.01 compared with matched group.Show that the special invigorating capsule of Testis et penis callorhini has the effect of obvious slow down aging.
Experimental example 2
Zoopery: use the special invigorating capsule of the Testis et penis callorhini of preparation in embodiment 1, the resisting fatigue effect of this product is tested.
Mice Grasping clubglass test:
1. laboratory animal: Kun Ming mice, draws from Shandong Province's animal center.
2. experimental technique:
(1) acute anti-fatigue test: Kunming mouse (22-25g) 50, male and female half and half, be divided into 5 groups at random, wherein blank group gavage every day normal saline 1.0ml/ only, positive controls only gives Radix Ginseng aqueous solution 1.0ml/, mice is not suspended from 150cm by only climbing with large, medium and small three dose sample (0.5g/kg, 0.1g/kg, 0.01g/kg) gavages after 2 hours by another three components, on diameter 0.75cm glass rod, the time that record mice drops down from glass rod, after mice falls, get eye socket blood immediately and survey urea nitrogen content.
(2) subacute anti-fatigue test: mice group method is the same, the continuous gavage of mice 15 days, in last gavage after 2 hours, by only carrying out Grasping clubglass test (bar is same as above), the time that record mice falls from glass rod, after mice falls, get eye socket blood immediately, adopt conventional diacetyl monoxime method to survey urea nitrogen content.Experimental result: refer to table 3, table 4.
Table 3 chmice acute resisting fatigue (pole-climbing) is tested
| Group | Number of animals | Climb the outstanding time | Urea nitrogen content (mg/L) |
| Blank | 10 | 362±16 | 17.75±0.41 |
| Radix Ginseng group | 10 | 371±24 | 16.76±0.42 |
| Heavy dose of group | 10 | 382±26 * | 16.97±0.39 * |
| Middle dosage group | 10 | 371±28 | 17.25±0.39 |
| Small dose group | 10 | 359±25 | 17.47±0.41 |
*compare P<0.05 with blank group and compare P>0.05 with Radix Ginseng group
The subacute resisting fatigue of table 4 mice (pole-climbing) is tested
| Group | Number of animals | Swimming time | Urea nitrogen content (mg/L) |
| Blank | 10 | 371±21 | 17.81±0.41 |
| Radix Ginseng group | 10 | 425±26 | 15.33±0.41 |
| Heavy dose of group | 10 | 497±28 | 15.16±0.38 * |
| Middle dosage group | 10 | 411±26 | 15.41±0.40 * |
| Small dose group | 10 | 383±27 | 16.61±0.39 |
*compare P<0.01 with blank group and compare P>0.01 with Radix Ginseng group
As can be seen from Table 3, namely take the special invigorating capsule powder of Testis et penis callorhini has antifatigue effect to a certain degree at short notice, and in body, blood urea nitrogen accumulation has minimizing trend.As can be seen from Table 4, after taking Testis et penis callorhini special invigorating capsule a period of time, mice pole-climbing is climbed the outstanding time and is obviously extended, and in body, blood urea nitrogen accumulation obviously reduces, and shows that the special tonic wine of Testis et penis callorhini has obvious antifatigue effect.
Experimental example 3
The special invigorating capsule usage and dosage of Testis et penis callorhini of the present invention: oral, is grown up every day 2.
The symptoms such as insomnia and dreamful sleep, physical fatigue and lassitude of spirit, neurasthenia, physical weakness, alopecia senilism are suffered from for subjects with 100, adopt and take 2 for each person every day, take 30 days, after the oral health-caring capsule of the present invention of experimenter, 15% takes effect obviously or cures, 75% patients takes a turn for the better, and 10% patient outcome is not obvious.
Above disclosedly be only preferred embodiment of the present invention, certainly can not limit the interest field of the present invention with this, therefore with any amendment, equivalent variations, improvement etc. that the claims in the present invention are done, the scope that the present invention is contained all should be included in.
Claims (3)
1. the special invigorating capsule of Testis et penis callorhini, is characterized in that: the raw material of its effective ingredient consists of: Testis et penis callorhini 1-7 part, Herba Epimedii 50-120 part, Radix Ginseng 10-70 part, Fructus Amomi 15-60 part, Flos Carthami 10-110 part, Fructus Jujubae 10-110 part, Poria 50-120 part, Rhizoma Dioscoreae 50-120 part, Fructus Lycii 50-120 part, Cortex Cinnamomi 10-70 part, Cortex Eucommiae 20-70 part, Fructus Schisandrae Chinensis 10-60 part, Herba Cistanches 20-60 part;
Its preparation method comprises the steps:
(1) medical material is taken by weight, for subsequent use;
(2) Testis et penis callorhini is pulverized after vacuum drying at 30-60 DEG C, sieve, make fine powder for subsequent use;
(3) by after Radix Ginseng, Flos Carthami, Fructus Amomi mixing, pulverize, sieve, make fine powder for subsequent use;
(4) by after other residue medical material mixing such as Herba Epimedii, add water boil, after boiling, 2h filters, and obtains first time filtrate; Repeat to add water boil to above-mentioned medical material, after boiling, 2h filters, and obtains second time filtrate; Merge twice filtrate, by filtrate concentrating under reduced pressure, obtain concentrated solution I;
(5) in concentrated solution I, add 95% ethanol, limit edged stirs, and at 0 ~ 5 DEG C, cold preservation leaves standstill 24h, gets supernatant; The supernatant of taking-up is carried out second time concentrating under reduced pressure, and concentrate and become concentrated solution II, at 40-70 DEG C, vacuum drying is dry cream, pulverizes and sieves, and obtains fine powder for subsequent use;
(6) by filled capsules after the fine powder mix homogeneously that obtains in step (2), step (3) and step (5), the special invigorating capsule of Testis et penis callorhini is;
In described step (5), 95% ethanol adds 1-4 times that quality is concentrated solution I quality;
The density of described concentrated solution I is 1.12-1.14g/cm
3; The density of concentrated solution II is 1.36-1.40g/cm
3.
2. the special invigorating capsule of Testis et penis callorhini according to claim 1, is characterized in that: the raw material of its effective ingredient consists of: Testis et penis callorhini 2-6 part, Herba Epimedii 55-110 part, Radix Ginseng 15-60 part, Fructus Amomi 20-55 part, Flos Carthami 15-100 part, Fructus Jujubae 15-100 part, Poria 55-120 part, Rhizoma Dioscoreae 55-120 part, Fructus Lycii 55-120 part, Cortex Cinnamomi 15-65 part, Cortex Eucommiae 25-65 part, Fructus Schisandrae Chinensis 15-57 part, Herba Cistanches 25-55 part.
3. the special invigorating capsule of Testis et penis callorhini according to claim 1, is characterized in that: described in sieve the order number of sieve used in operation between 80-100 order.
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| CN101381668A (en) * | 2008-09-18 | 2009-03-11 | 何官平 | Method for preparing health-care medicinal liquor |
| CN102212446A (en) * | 2011-05-09 | 2011-10-12 | 成中方 | Physical strength strengthening health-care medicinal liquor capable of tonifying kidney, strengthening yang and enhancing immunity and preparation method thereof |
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