CN106620633A - Skin repairing cream for tumor patients and preparation method of skin repairing cream - Google Patents
Skin repairing cream for tumor patients and preparation method of skin repairing cream Download PDFInfo
- Publication number
- CN106620633A CN106620633A CN201710124237.4A CN201710124237A CN106620633A CN 106620633 A CN106620633 A CN 106620633A CN 201710124237 A CN201710124237 A CN 201710124237A CN 106620633 A CN106620633 A CN 106620633A
- Authority
- CN
- China
- Prior art keywords
- extract
- skin
- water
- tumor patients
- extractive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/09—Lichens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/33—Cactaceae (Cactus family), e.g. pricklypear or Cereus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the technical field of skin repairing, and in particular relates to skin repairing cream for tumor patients and a preparation method of the skin repairing cream. The skin repairing cream for tumor patients is prepared from the following raw materials: an alcohol humectant, cocoa seed fat, hydrogenated polydecene, hydrolyzed collagen, radix scutellariae extract, shaddock fruit extract, perillae extract, herba centellae extract, cactus extract, rhizoma smilacis glabrae extract, zanthoxylum piperitum fruit extract, radix pulsatillae cernuae extract, usnea barbata extract, ginger root extract, bisabolol, an emulsifying agent, panthenol, allantoin, hyaluronic acid and water. For the skin repairing cream, the essence ingredients extracted from natural plant are adopted, so that no irritation and side effects exist, various skin problems caused by treatment for tumor patients can be effectively alleviated, the deep moisturizing of skin is facilitated, and the repair of the injured skin is promoted.
Description
Technical field
The present invention relates to skin repair technical field, more particularly to a kind of used by tumor patients skin repair breast and its making side
Method.
Background technology
At present, as the entirety of medical technology is improved, the hope of rehabilitation is brought to increasing tumor patient, it hits
It is the Main Means for treating tumour at present to treatment, chemotherapy, radiotherapy, but, due to the opposing of tumor patient body during one's sickness
The side effect that power weakens and oncotherapy causes, causes tumor patient easily to occur various skin problems over the course for the treatment of,
For example, the scytitises such as dry skin, cracking, the furfur that dermatitis causes, itch, pain that fash causes, hand-foot syndrome.
By to fash reaction and the research of curative effect of medication, specifically studying parameter for ethnic group, fash classification, EGFR-TKls
Medicine (a class target therapeutic agent), patient populations, objective extenuate rate, disease control rate, progression free survival phase and total existence
Phase each parameter, research shows that the objective of fash occur extenuates rate and disease control rate raising, Progression free survival and Overall survival increasing
It is long.
By to clothes for patients grinding with the incidence of EGFR-TKIs skin adverse events in III phase of line randomized clinical trial
Study carefully, concrete research parameter is sending out for medicament categories, skin rash typus, the incidence of all fash classification, 1 grade of fash and 2 grades of fash
The incidence of raw rate, 3 grades of fash and 4 grades of fash, research show the fash incidence of the effective patients of EGFR-TKIs it is many 70% with
On.
By the research for causing the incidence of hand-foot syndrome to Treated with Chemotherapeutic Drugs thing, show brothers' synthesis that chemotherapy causes
Disease is more more than 50%.
Additionally, administering 2 grades or 2 grades of generation in two methods after relatively more preventative skin nursing and the generation of dermal toxicity symptom
Above Skin toxicity situation, research shows, preventative skin nursing patient occurs sending out for 2 grades or more than 2 grades dermal toxicities
Raw rate is 29%；Dermal toxicity symptom treats 2 grades of generation or the incidence of more than 2 grades of dermal toxicity after occurring be 62%.
Skin problem occurs over the course for the treatment of in tumor patient cannot be avoided, and skin uncomfortable patient is being nursed
When, it is impossible to it is enough using excitant perfumed soap, washing lotion containing spices, this is because spices sensitization risk is larger, it is impossible to enough use
Oiliness skin care item, or the skin care item without moisture-keeping functions, in order to avoid skin involvement.
Currently, it is clinically uneven for treating the method for the skin problem that oncotherapy causes, there is no a kind of universal
Applicable scheme.Clinical practice proves that chemical drug class is larger to skin irritatin, and hormone medicine clinical application is remained in dispute, and
There are the side effects such as delay wound healing.
Therefore, need it is a kind of it is nonirritant, have no side effect, effectively alleviate tumor patient due to treating the various skins for causing
Problem, is conducive to the deeply preserving moisture of skin, promotes used by tumor patients skin repair breast of damaged skin reparation and preparation method thereof.
The content of the invention
(1) technical problem to be solved
In order to solve the problems referred to above of prior art, the present invention provides a kind of nonirritant, has no side effect, effectively alleviates swollen
Knurl patient is conducive to the deeply preserving moisture of skin due to treating the various skin problems for causing, the tumour for promoting damaged skin to repair
Patient is with skin repair breast and preparation method thereof.
(2) technical scheme
In order to achieve the above object, the main technical schemes that the present invention is adopted include：
The present invention proposes a kind of used by tumor patients skin repair breast, is made up of the raw material of following mass percent：
Alcohols NMF 3%-10%, cocoa seed fat 5%-10%, the poly- certain herbaceous plants with big flowers alkene 3%-6% of hydrogenation, hydrolytic collagen 1%-
10%th, Baical Skullcap root P.E 0.2%-2%, Fructus Citri grandis extract 0.5%-3%, extractive of perilla 0.5%-5%, Gotu Kola P.E
0.5%-2.5%, Radix et Caulis Opuntiae Dillenii extract 0.5%-3.5%, Rhizoma Smilacis Glabrae extract 0.5%-2.5%, long and thin hot pepper berry extract
0.2%-2%, pasque flower extract 0.5%-2%, palpus extractive of usnea 0.5%-4%, ginger-root extract 0.01%-
1%th, bisabolol 0.1%-2%, emulsifying agent 3.6%-12%, panthenol 0.5%-5%, allantoin 0.1%-1%, hyaluronic acid
The water of 0.01%-1.5% and surplus.
Further, the alcohols NMF includes butanediol, glycerine and propane diols.
Further, the emulsifying agent includes cetearyl glucoside, cetanol, stearyl alcohol and cetostearyl alcohol.
Further, it is made up of the raw material of following mass percent：
Butanediol 2%-4.5%, glycerine 1%-2.5%, propane diols 1%-2.5%, cocoa seed fat 6%-8%, hydrogenation are poly-
Certain herbaceous plants with big flowers alkene 4%-5%, hydrolytic collagen 3%-7%, Baical Skullcap root P.E 0.3%-1%, Fructus Citri grandis extract 1%-2.5%, purple perilla are extracted
Thing 1%-2%, Gotu Kola P.E 1%-2%, Radix et Caulis Opuntiae Dillenii extract 1%-3%, Rhizoma Smilacis Glabrae extract 1%-2%, prickly ash berries
Extract 0.22%-0.5%, pasque flower extract 1%-1.8%, palpus extractive of usnea 1.5%-3.5%, race are extracted
Thing 0.03%-0.08%, bisabolol 0.12%-0.17%, cetearyl glucoside 0.2%-0.5%, cetanol 2%-
3%th, stearyl alcohol 1.5%-2.5%, cetostearyl alcohol 1.4%-2%, panthenol 2.5%-3.5%, allantoin 0.3%-0.8%,
The water of hyaluronic acid 0.05%-1% and surplus.
Further, it is made up of the raw material of following mass percent：
Butanediol 4%, glycerine 2%, propane diols 2%, cocoa seed fat 7%, hydrogenate poly- certain herbaceous plants with big flowers alkene 4.5%, hydrolytic collagen 5%,
Baical Skullcap root P.E 0.5%, Fructus Citri grandis extract 2%, extractive of perilla 1.2%, Gotu Kola P.E 1.5%, Radix et Caulis Opuntiae Dillenii extract
2%th, Rhizoma Smilacis Glabrae extract 1.3%, long and thin hot pepper berry extract 0.3%, pasque flower extract 1.2%, palpus extractive of usnea
2.5%th, ginger-root extract 0.05%, bisabolol 0.15%, cetearyl glucoside 0.3%, cetanol 2.4%, tristearin
The water of alcohol 2%, cetostearyl alcohol 1.5%, panthenol 3%, allantoin 0.5%, hyaluronic acid 0.08% and surplus.
The present invention also proposes a kind of preparation method for preparing used by tumor patients skin repair breast as described above, bag
Include following steps：
S1, A phases raw material is added and stirred in emulsion tank, and heated；
S2, B phases raw material is added and stirred in oil phase tank, and heated；
S3, by B phases raw material add emulsion tank in, emulsifying；
C phase raw materials are added after S4, cooling, is stirred；
S5, cooling inspection, it is qualified after discharging, it is filling.
Wherein, the A phases raw material includes butanediol, glycerine, propane diols, allantoin and water；
The B phases raw material includes cocoa seed fat, hydrogenates poly- certain herbaceous plants with big flowers alkene and emulsifying agent；
The C phases raw material includes the mixed liquor of hydrolytic collagen, Baical Skullcap root P.E and water formation, and Fructus Citri grandis extract and water are formed
Mixed liquor, the mixed liquor that extractive of perilla and water are formed, the mixed liquor that Gotu Kola P.E and water are formed, Radix et Caulis Opuntiae Dillenii extract
The mixed liquor that the mixed liquor formed with water, Rhizoma Smilacis Glabrae extract and water are formed, butanediol, long and thin hot pepper berry extract, pasque flower
The mixture of the mixed liquor that extract, palpus extractive of usnea are mixed to form, ginger-root extract and bisabolol, panthenol, hyalomitome
Acid, Yi Jishui.
Further, in S1, it is heated in the range of 83 DEG C -87 DEG C；In S2, it is heated in the range of 83 DEG C -87 DEG C；
In S3, the temperature of emulsifying is 80 DEG C -85 DEG C；In S4, it is cooled in the range of 43 DEG C -47 DEG C；In S5, it is cooled to
In the range of 33 DEG C -37 DEG C；
Preferably, in S1,85 DEG C are heated to；In S2,85 DEG C are heated to；In S3, the temperature of emulsifying is 83
℃；In S4,45 DEG C are cooled to；In S5,35 DEG C are cooled to.
Further, it is further comprising the steps of before S1：
S0, C phase raw materials are stirred it is standby.
Further, in S5, the first parameter of inspection includes the hydrolytic collagen, Baical Skullcap root P.E, the shaddock that contain in maintenance breast
Berry extract, extractive of perilla, Gotu Kola P.E, Radix et Caulis Opuntiae Dillenii extract, Rhizoma Smilacis Glabrae extract, long and thin hot pepper berry extract, Korea
Radix Pulsatillae extract, palpus extractive of usnea, ginger-root extract, bisabolol, panthenol, allantoin, hyaluronic acid account for respectively total amount
Mass percent.
Further, in S5, the second parameter of inspection is the content of microorganism in maintenance breast.
(3) beneficial effect
The invention has the beneficial effects as follows：
In the used by tumor patients skin repair breast of the present invention, Baical Skullcap root P.E can effectively extenuate the town that scytitis causes
Bitterly, suppress the bioactivators such as histamine to generate, mitigate pain.Fructus Citri grandis extract has effect that is pure and fresh, calm and releiving, can
Promote local blood fortune, help skin reparation.Extractive of perilla can effectively reduce DNA oxidative damages, effectively remove free radical, from
And promote damaged skin reparation.Gotu Kola P.E can swelling and pain relieving, the coupling part of compact epidermal cell and dermal cell,
Increase the pliability of skin, Gotu Kola P.E has sterilized, antiinflammation, stimulates circulation, and effectively facilitates skin wound
Healing, effectively facilitates skin histology reparation.Baical Skullcap root P.E and Gotu Kola P.E compound use, reach the effect of mutual gain
Really, more preferable swelling and pain relieving, effectively alleviates the symptom of skin swelling and pain.Radix et Caulis Opuntiae Dillenii extract has the work to skin Yellow Gentian Extract
Property composition, and remove and suppress free radical vitamin C, play moisturizing, antiallergy and the effect for skin of releiving.Smilax is carried
Take thing has facilitation to the activity of cathepsin, can strengthen skin metabolism, strengthens skin resistance, there is anti-aging
Effect.Long and thin hot pepper berry extract is natural antiseptic agent and bacteriostatic agent, with antibacterial, antiallergy, calm skin, moisturizing effect.
Pasque flower extract plays the role of antimycotic, resisting pathogenic microbes.Must extractive of usnea as natural antiseptic agent, with light
Spectrum antibacterial, the effect for promoting wound healing.Ginger-root extract plays a part of antiallergic and repairs the skin for having inflammation damnification.It is red not have
Medicine alcohol has repair and reconstruction skin self-protection barrier function, it is possible to increase the immunity of skin.Bisabolol and race are carried
Both things synergy is taken, can simultaneously suppress inflammation medium such as TNF (TNF-α), interleukins (1L-
1 α) etc. release, prevention and delaying skin inflammation generation.Panthenol easily permeates cuticula, contributes to itch of releiving.Carry in shaddock fruit
Under taking the synergy of thing and panthenol, skin can be releived, and strengthen absorption of the skin to nutrition, so as to strengthen the immunity of skin
Level.Allantoin has lucifuge, sterilization and anticorrosion, pain relieving, antioxidation, and skin can be made to keep moisture content, moistens and soft, together
When, with protective tissue, hydrophilic and water suction, prevent moisture from distributing, promotion organization growth, cell metabolism, cutin-softening layer
The effect of albumen.
Additionally, alcohols NMF has moistening effect.Cocoa seed fat has moisturizing grease, the effect of water lock moisturizing.Hydrogenation
Poly- certain herbaceous plants with big flowers alkene has skin-moisturizing, skin grease, repairs the effect of skin barrier.Hydrolytic collagen has moisturizing, repairs the work of dry skin
With.Hyaluronic acid is able to maintain that the moisture in dermal connective tissue, makes connective tissue in rarefaction, prevent collagen by
Dissolved state is changed into insoluble state, and tissue water retention is primarily served in the dermis.
The used by tumor patients skin repair breast of the present invention is the skin repair product for tumor patient skin design, is adopted
Natural plant extraction essential ingredient, it is non-stimulated, have no side effect, can effectively alleviate tumor patient due to treating the various skins for causing
Skin problem, is conducive to the deeply preserving moisture of skin, promotes damaged skin reparation.
It is respectively that A phase raw materials, the stirring of B phases raw material is equal in the preparation method of the used by tumor patients skin repair breast of the present invention
Even and heat, afterwards both mixing emulsifyings, are eventually adding C phases raw material and stir, cooling detection, it is qualified after discharging,
It is filling, so, it is ensured that above-mentioned each raw material mixed dissolution is more uniform abundant, and does not destroy active ingredient, so as to ensure each
Active ingredient can alleviate the various skin problems occurred in tumor patient therapeutic process.Using prepared by above-mentioned preparation method swelling
Knurl patient is non-stimulated with skin repair breast, has no side effect, and can effectively alleviate tumor patient due to treating the various skins for causing
Problem, is conducive to the deeply preserving moisture of skin, promotes damaged skin reparation.
Specific embodiment
In order to preferably explain the present invention, in order to understand, by specific embodiment, the present invention is described in detail.
Embodiment one
Take the raw material of below 100g quality altogether：Butanediol 4g, glycerine 2g, propane diols 2g, cocoa seed fat 7g, the poly- certain herbaceous plants with big flowers of hydrogenation
Alkene 4.5g, hydrolytic collagen 5g, Baical Skullcap root P.E 0.5g, Fructus Citri grandis extract 2g, extractive of perilla 1.2g, Gotu Kola P.E
1.5g, Radix et Caulis Opuntiae Dillenii extract 2g, Rhizoma Smilacis Glabrae extract 1.3g, long and thin hot pepper berry extract 0.3g, pasque flower extract 1.2g, palpus
Extractive of usnea 2.5g, ginger-root extract 0.05g, bisabolol 0.15g, cetearyl glucoside 0.3g, cetanol 2.4g,
The water of stearyl alcohol 2g, cetostearyl alcohol 1.5g, panthenol 3g, allantoin 0.5g, hyaluronic acid 0.08g and surplus.
Specifically, the preparation method of the used by tumor patients skin repair breast of the present embodiment, comprises the steps：
S0, C phase raw materials are stirred it is standby；
S1, A phases raw material is added and stirred in emulsion tank, and be heated to 85 DEG C；
S2, B phases raw material is added and stirred in oil phase tank, and be heated to 85 DEG C；
S3, by B phases raw material add emulsion tank in, emulsifying maintains the temperature at 83 DEG C；
S4, be cooled to 45 DEG C addition C phase raw materials, stir；
S5, be cooled to 35 DEG C of inspections, it is qualified after discharging, filling.
Wherein, the A phases raw material includes butanediol, glycerine, propane diols, allantoin and water.
The B phases raw material includes cocoa seed fat, hydrogenates poly- certain herbaceous plants with big flowers alkene, cetearyl glucoside, cetanol, stearyl alcohol and whale
Wax stearyl alcohol.
The C phases raw material includes the mixed liquor of hydrolytic collagen, Baical Skullcap root P.E and water formation, and Fructus Citri grandis extract and water are formed
Mixed liquor, the mixed liquor that extractive of perilla and water are formed, the mixed liquor that Gotu Kola P.E and water are formed, Radix et Caulis Opuntiae Dillenii extract
The mixed liquor that the mixed liquor formed with water, Rhizoma Smilacis Glabrae extract and water are formed, butanediol, long and thin hot pepper berry extract, pasque flower
The mixture of the mixed liquor that extract, palpus extractive of usnea are mixed to form, ginger-root extract and bisabolol, panthenol, hyalomitome
Acid, Yi Jishui.
In the present embodiment, the mixed solution that Baical Skullcap root P.E and water are formed, the mixed solution that Fructus Citri grandis extract and water are formed,
The mixed solution that the mixed solution that extractive of perilla and water are formed, Gotu Kola P.E and water are formed, Radix et Caulis Opuntiae Dillenii extract and water
The mixed solution that the mixed solution of formation, Rhizoma Smilacis Glabrae extract and water are formed, the content of water can be to appoint in each mixed solution
Meaning, but must assure that in ultimogenitary finished product, the mass percent of above-mentioned each raw material is respectively 0.5%, 2%,
1.2%th, 1.5%, 2%, 1.3%.
In the present embodiment, the content of the butanediol in butanediol and C phase raw materials in A phase raw materials can be any proportioning,
But must assure that in ultimogenitary finished product, the mass percent of butanediol is 4%.
In the present embodiment, the content of the water in A phase raw materials can be arbitrary, but must assure that in ultimogenitary finished product
In, butanediol, glycerine, propane diols, the mass percent of allantoin are respectively 4%, 2%, 2%, 0.5%.
In the present embodiment, the water of surplus refers to that 100g deducts remaining all water after the weight of other raw materials, this enforcement
Water in example is deionized water.
In S5, the first parameter of inspection includes that the hydrolytic collagen contained in maintenance breast, Baical Skullcap root P.E, shaddock fruit are extracted
Thing, extractive of perilla, Gotu Kola P.E, Radix et Caulis Opuntiae Dillenii extract, Rhizoma Smilacis Glabrae extract, long and thin hot pepper berry extract, pasque flower
Extract, palpus extractive of usnea, ginger-root extract, bisabolol, panthenol, allantoin, hyaluronic acid account for respectively the quality of total amount
Percentage.Second parameter of inspection is the content of microorganism (such as bacterium, mould, fungi, mould, mould) in maintenance breast.It is former
The qualified standard of material content and content of microorganisms is the material and microorganism detection standard for meeting country to skin care item safe handling.
Embodiment 2-9
With embodiment 1 preparation process be similar to, embodiment 2-9 be by adjust preparation process each raw material quality, S1
In heating-up temperature, the heating-up temperature in S2, the emulsifying temperature in S3, the cooling temperature in cooling temperature and S5 in S4
Degree is newborn to prepare used by tumor patients skin repair.Embodiment 2-9 is concrete such as to the preparation situation of used by tumor patients skin repair breast
Shown in table 1.
Table 1：Preparation situation of embodiment 2-9 to used by tumor patients skin repair breast
In the used by tumor patients skin repair breast of the present invention, various moisturizing ingredients are with the addition of, including common alcohols is protected
Humectant, cocoa seed fat and the poly- certain herbaceous plants with big flowers alkene of hydrogenation, its primary efficacy is moisturizing grease, water lock moisturizing, repairs skin barrier, is effectively prevented
Dry skin, the cracking caused due to anti-tumor medicine toxicity, and then the even more serious skin problem for causing.
Butanediol is water-phase material, is used as NMF and synergist, in terms of moisturizing, because butanediol is small molecule
Moisturizing composition, with moisture-keeping function, while also there is certain bacteriostasis.
Glycerine can be in absorption air moisture, prevent vapor from evaporating, so as to reach moistening effect, make as NMF
With.
Propane diols is water-phase material, is used as NMF.
Cocoa seed fat is efficient antioxidant, with lubricity, non-greasy, it is possible to decrease oily substance it is greasy, also
With significant water lock moistening effect, Glycerin effect is obvious.
Hydrogenate poly- certain herbaceous plants with big flowers alkene and there is skin-moisturizing, skin grease, repair the effect of skin barrier.
Because the skin of tumor patient is due to the stimulation of medicine or ray in treatment, skin sensitivity is caused to increase, therefore
In the skin repair breast of the present invention, add various natural antiallergic plant components, functionally anti-inflammatory, antibacterial, antiallergy, from should
Use and be more suitable for tumor patient, including Baical Skullcap root P.E, Gotu Kola P.E, extractive of perilla, Radix et Caulis Opuntiae Dillenii extract, soil Fu
Siberian cocklebur extract and Fructus Citri grandis extract etc..
The preparation method of Baical Skullcap root P.E is：The scutellariae,radix powder that comminution pretreatment is crossed pours extraction kettle into, by extraction kettle
Sealing, opens gas cylinder, hot water circuit, drives compressor, makes the temperature of extraction kettle in 45 DEG C, pressure in 8MPa, circulates system stability
1h, turns off compressor power, and decompression operation opens carbon dioxide gas bottle valve, and gas recovery opens atmospheric valve, emptying system
Interior residual gas, is after zero, to open separating still valve after system pressure, collects extracted products, puts drying in oven.
The preparation method of Gotu Kola P.E is：Centella is immersed in 80% ethanol solution, per the addition of 1g centellas
15mL ethanol solutions, with ultrasonic extraction 5 times, 0.5 hour every time, merge extract, are evaporated to without alcohol taste, and it is heavy that centrifugation is discarded
Form sediment, prepare loading, weigh the AB-8 resins with the weight such as centella raw material, wash through alcohol and post is filled after washing process, add water flushing
Pillar until no longer contain bubble, loading in post, standing adsorption press after 2 hours water, 25% ethanol, 55% ethanol, 75% ethanol,
The order of 95% ethanol is eluted, and with the flow of 5 minutes 100ml extract is accepted, respectively using 3 posts, 5 posts, 3 posts, 3 posts, 2
Column volume solution is eluted, and gained eluent is separately evaporated to without alcohol taste per post.
The preparation method of Fructus Citri grandis extract is：S1, take fresh shaddock pericarp shredded, 45 DEG C of -70 DEG C of oven for drying and
Pulverization process, obtains powder；S2, take the powder that step 1 obtains and be heated to reflux extracting at twice with 90% ethanol solution, for the first time
2 hours, second 1.5 hours, obtain oil-like extracts；S3, oil-like extracts and petroleum ether that step 2 obtains are taken by by volume
Than 1:1.5 mixing are extracted, and are repeated 3 times, and a layer extract volatilization petroleum ether is removed after extraction, obtain extract after degreasing；S4、
Extract carries out column chromatography using macroreticular resin after extracting degreasing, with the ethanol elution of concentration 45%-70%, collects eluent, washes
De- liquid rotates to obtain Fructus Citri grandis extract.
The preparation method of extractive of perilla is：The perilla leaf of 100g is added into the water of 4L, is extracted in 85 DEG C of water-bath
60min, uses gauze coarse filtration, adjusts pH value to 2.5-3 with hydrochloric acid, carries out suction filtration, and about clear liquid is pressed into volume 2 with ethyl acetate:1 extraction
3 times, combining extraction liquid, rotary evaporation removes ethyl acetate, the vacuum dried prepared extractive of perilla of concentrate.
The preparation method of Radix et Caulis Opuntiae Dillenii extract is：Fresh cactus is taken, after deburring peeling, is cleaned, chopping, homogenate is used
90% ethanol soaking at room temperature 48 hours, removes liposoluble substance, dries, crushes, crosses 200 mesh sieves, afterwards residue in 85 DEG C
The cactus powder for taking portion is added in 30 parts of distilled water, and homogenate adds 1% pectase, in temperature 45 C, the ring of pH3.4
In border, it is centrifuged after extraction 1.3h, merges supernatant, reduced pressure concentration adds afterwards 85% ethanol of 4 times of volumes, stands 12 hours, treats
After producing a large amount of white precipitates, precipitation is collected by centrifugation, then with distillation water dissolves, is concentrated to the 1/2 of about stoste volume, 5 times repeatedly
Dissolving, centrifugation, removing protein, while distilled water is dialysed 12h, collects solution in bag filter, and precipitation is abandoned in centrifugation, and supernatant Jing is cold
Jelly is drying to obtain Radix et Caulis Opuntiae Dillenii extract.
The preparation method of Rhizoma Smilacis Glabrae extract is：By 1:25 ratio adds the smilax powder dried in ethanol, profit
Extracted with ultrasonic assistant, Extracting temperature is 43 DEG C -47 DEG C, and extraction time is 1.5 hours, and supersonic frequency is 25KHz, filters it
Afterwards hydraulic pressure reclaims ethanol, obtains Rhizoma Smilacis Glabrae extract standby.
The preparation method of long and thin hot pepper berry extract is：The 1g prickly ash berries after drying will be cleaned and add the 27mL second that concentration is 78%
In alcohol extracting solvent, at a temperature of 83 DEG C -87 DEG C, refluxing extraction 1.5h, cooling, centrifugation, filtration, the extraction after filtration are incubated
Liquid reduced pressure concentration, freeze-drying is saved backup.
The preparation method of pasque flower extract is：The root for taking pasque flower that is clean, drying, chop up is some, leaching
Bubble 36h in 45 DEG C of water, after being diluted with water, decocts 3h and extracts, and period can add water, and filtration afterwards, reduced pressure concentration, vacuum are done
It is dry standby.
Must the preparation method of extractive of usnea be：The 27mL that concentration is 78% must be added the 1g after drying is cleaned in sunglo
Ethanol Extraction solvent, at a temperature of 83 DEG C -87 DEG C, is incubated refluxing extraction 1.5h, cooling, centrifugation, filtration, the extraction after filtration
Liquid reduced pressure concentration, freeze-drying is saved backup.
Hyaluronic acid is the one of the chief elements of corium, the moisture being able to maintain that in dermal connective tissue, makes connective tissue
In rarefaction, prevent collagen to be changed into insoluble state from dissolved state, special water conservation is primarily served in the dermis
Effect, while water conservation or good skin penetration enhancer, can help active ingredient preferably to absorb.
In accordance with cosmetic product formula constitution principle, the main several bases including described below of skin repair breast of the present invention
This module.
1st, emulsification system
In the skin repair breast of the present invention, using cetearyl glucoside, cetanol, stearyl alcohol and cetostearyl alcohol
Used as emulsifying agent, they possess natural gentle property, the security with height and mildness, the skin tolerance of high level
Property, it is suitable for the tumor patient of skin sensitivity.
Cetearyl glucoside is used as a kind of solubilizer, and it is splendid with the compatibility of skin.
Cetanol, with non-greasy, Glycerin, strengthens the effect of skin water suction, while being also thickening as emulsifying agent
Agent, plays stable, thickening power.
Stearyl alcohol can increase the moisture holding capacity of skin repair breast as a kind of emulsifying agent.
Used as a kind of emulsifying agent, it can form one layer of oil film to cetostearyl alcohol in skin surface, prevent moisture of skin from scattering and disappearing,
With greasy feeling is suppressed, wax class raw material stickiness, the effect of true emulsion are reduced.
2nd, efficient public security system
Ginger-root extract is natural antiallergic composition, as a kind of anti-sensitizer, has good effect to preventing and treating allergic reaction,
Medicine antiallergic is compared, is had no side effect, reduce the application risk of skin user.
3rd, effect system
(1) bisabolol and ginger-root extract
Bisabolol is taken from one kind of chamomile and is releived element, is natural anti-inflammatory component, with repair and reconstruction skin from
My protective barrier function, it is possible to increase the immunity of skin.
Ginger-root extract has very strong oxidation resistance, plays a part of antiallergic and repairs the skin for having inflammation damnification.
Both bisabolol and ginger-root extract act synergistically, and can simultaneously suppress inflammation medium such as tumor necrosis factor
The release of sub (TNF-α), interleukins (1L-1 α) etc., prevention and the generation of delaying skin inflammation.
(2) Baical Skullcap root P.E and Gotu Kola P.E
Active component is scutelloside, flavonoids in Baical Skullcap root P.E, and its primary efficacy is anti-inflammatory, suppresses histamine release, from
And the analgesia that scytitis causes effectively is extenuated, and suppress the bioactivators such as histamine to generate, mitigate pain.
Active component is asiatic centella total saponins in Gotu Kola P.E, and its Main Function is to repair skin, strengthens skin screen
Barrier, reaches antiallergic effect.Gotu Kola P.E can swelling and pain relieving, the coupling part of compact epidermal cell and dermal cell,
Increase the pliability of skin, Gotu Kola P.E has sterilized, antiinflammation, stimulates circulation, and effectively facilitates skin wound
Healing, effectively facilitates skin histology reparation.Once it has been reported that, the creams agent of the alcohol extracting thing containing centella 0.25%-2% can be solved
Certainly skin problem, obtains good effect.
(3) extractive of perilla and Radix et Caulis Opuntiae Dillenii extract
Extractive of perilla, with antioxidation activity, can be removed containing various flavone compounds and plant polyphenol
Oxygen radical, reduces DNA oxidative damages, so as to promote damaged skin reparation.
Radix et Caulis Opuntiae Dillenii extract is the root of Cactaeous plants cactus and the extract of stem, the amino acid being rich in, sterol, super
The chemical composition such as superoxide dismutase (SOD) and polysaccharide is all the active component to skin Yellow Gentian Extract, and it contain it is rich
Rich vitamin C has the ability removed and suppress free radical, with antiallergy, moisturizing, anti-oxidant, skin of releiving effect,
Use as antiallergic antipruritic in the present embodiment.
The collaboration of both extractive of perilla and Radix et Caulis Opuntiae Dillenii extract has gain effect, does not suppress mutually, so as to difference
Angle preferably promote skin histology reparation.And the antioxidation of two kinds of compositions, can effectively prevent other plants in raw material
The oxidation deterioration of thing composition, extends the effective time that product is used.
(4) Fructus Citri grandis extract and panthenol
Active component is aurantiin and flavonoid glycoside in Fructus Citri grandis extract, with promoting local blood fortune, help skin reparation, clear
Newly, effect that is calm, releiving.
Panthenol is the precursor of vitamin B5, and vitamin B5 is nutrient content necessary to skin.Panthenol more holds than vitamin B5
Easily it is absorbed by organisms, and is quickly converted to vitamin B5 in vivo, participates in the physiological action of tissue.Due to receiving targeted therapy
In patient, majority can be because drug toxicity causes fash itch, panthenol easily to permeate cuticula, contribute to itch of releiving.
Under the synergy of Fructus Citri grandis extract and panthenol, skin can be releived, and strengthen absorption of the skin to nutrition, from
And strengthen the immune level of skin.
(5) Rhizoma Smilacis Glabrae extract and allantoin
Active component is flavones in Rhizoma Smilacis Glabrae extract, is the extract of the dry rhizome of liliaceous plant smilacis glabra,
Can promotion organization growth, cell metabolism, cutin-softening layer albumen.When being applied to ulcer and the skin for suppurating, these property
Can be particularly evident, so having functions that to accelerate speed of wound healing, it is mainly incorporated as immunodepressant, strengthens skin opposing
Power.
Allantoin is a kind of amphoteric compound, can form double salt with reference to many kinds of substance, is good NMF and anti-sensitizer,
With lucifuge, sterilization and anticorrosion, pain relieving, antioxidation, skin can be made to keep moisture content, be moistened and soft, maintain skin moisture
Physiological equilibrium, with protective tissue, it is hydrophilic, absorb water and prevent moisture from distributing, promotion organization growth, cell metabolism softens
Effect of cuticula albumen.
Allantoin can directly act on keratin, increase and promote cuticula hydratability, reduce moisture loss.Due to swollen
In knurl treatment, serious skin injury can accelerate the secondary infection of skin, and to patient's treatment extreme influence is caused.Allantoin
Good humidity is provided for cytothesis, Skin Cell can be promoted to regenerate, accelerate wound healing, be that the good of skin injury is healed
Mixture.
Both Rhizoma Smilacis Glabrae extract and allantoin are used cooperatively, and can alleviate stimulation of the active matter to skin, tie up skin
Health status is held, the stimulation of favourable opposing antineoplastic.
(6) hydrolytic collagen
Hydrolytic collagen is the micromolecular collagen for being hydrolyzed by macromolecular collagen protein and being come, and is easily absorbed by the skin, with angle
Matter albumen has similar amino acid structure, and skin-friendly is good, and used as NMF, moistening effect is general, but, hydrolytic collagen can be with skin
The protein on skin surface is combined, and supplements the collagen being lost in, and for skin histology reparation quality raw materials are provided, and having improves skin quality
Effect, this is that many NMFs do not possess, therefore, hydrolytic collagen and moisturizing ingredient such as Radix et Caulis Opuntiae Dillenii extract, allantoin one
Rising can play preferably reparation dry skin function.
4th, protective system
In the skin repair breast of the present invention, synthetic preservative is replaced using natural antiseptic agent, it is to avoid synthetic preservative pair
Patient skin increases to stimulate.Three kinds of natural antiseptic agents include：Long and thin hot pepper berry extract, pasque flower extract and palpus sunglo are extracted
Thing.
Long and thin hot pepper berry extract has antibacterial, antiallergy, calm skin, the effect of moisturizing, is natural antiseptic agent and bacteriostatic agent.
Pasque flower extract for ranunculaceae plant Chinese bulbul root extract, be natural antiseptic agent, with it is antimycotic,
The effect of resisting pathogenic microbes, and calm, analgesia and anti-spasm effect.
Palpus sunglo belongs to lichens in palpus extractive of usnea, the effect with spectrum antibacterial, promotion wound healing, in this reality
Apply in example and used as natural antiseptic agent.
Above-mentioned three kinds of natural antiseptic agents are respectively provided with good anti-various bacteria, fungi, effect of pathogenic microorganism.Three kinds into
Divide and extract and obtain from plant, can reach superior antiseptic effect, extend the shelf-life of product, and have no side effect, it is more applicable
In the tumor patient of skin sensitivity.
5th, sense organ modification system
In the product design of the used by tumor patients skin repair breast of the present invention, any spices and pigment is not added with, by
In most spices and pigment be sensitive-skinned anaphylactogen.Therefore it is former without any chemical synthesis in product formula design
Material, pure to ensure the better tasting soft of product, the special population as tumor patient easily receives.
In sum, used by tumor patients skin repair breast of the invention is the skin repair for tumor patient skin design
Product, it is non-stimulated using natural plant extraction essential ingredient (such as any of the above natural plant extracts), have no side effect, can
Effectively alleviate tumor patient due to treating the various skin problems for causing, be conducive to the deeply preserving moisture of skin, promote damaged skin
Repair.
It is respectively that A phase raw materials, the stirring of B phases raw material is equal in the preparation method of the used by tumor patients skin repair breast of the present invention
Even and be heated to 83 DEG C -87 DEG C, both mixing emulsifyings afterwards, 80 DEG C -85 DEG C of keeping temperature is finally cooled to 43 DEG C -47
DEG C add and C phases raw material and to stir, be cooled to 33 DEG C of -37 DEG C of detections, it is qualified after discharging, filling, so, it is ensured that above-mentioned each
Raw material mixed dissolution is more uniform abundant, and does not destroy active ingredient, suffers from so as to ensure that each active ingredient can alleviate tumour
The various skin problems occurred in person's therapeutic process.The used by tumor patients skin repair breast prepared using above-mentioned preparation method is stingless
Swash, have no side effect, can effectively alleviate tumor patient and protect due to treating the various skin problems for causing, the depth for being conducive to skin
It is wet, promote damaged skin reparation.
For tumor patient treat during occur skin problem, Consensus of experts nursing suggestion be, preventive use skin
Skin nursing product, strengthens skin barrier function, when there are 3 grades of dermoreactions, needs to be discontinued or reduces dosage, until dermoreaction
Can recover medication after less than 2 grades.
Specifically, (NCI-CTCAEVer.4.03) standard is classified according to National Cancer Institute adverse drug reaction,
EGFR-TKIs dermoreactions classification is divided into 5 grades：There is fash and warts in 1 grade of skin surface referred to less than 10%, and skin is done
Dry, rubescent, once in a while papilla, does not affect daily routines；2 grades refer to more than or equal to 10% and the skin surface less than 50% is occurred in that
And fash and warts, papilla, light-moderate symptoms (itch, pain), the daily activity of slight effect；3 grades refer to more than or equal to 50%
Skin surface covers fash and warts, and area skin of extending and open hardening, thinning of skin is serious to touch a tender spot, and affects quality of life,
Excite infection；4 grades refer to that fash and warts occurs in sudden and violent leakage skin, and area skin of extending and open hardening, thinning of skin is serious to touch
Bitterly, quality of life is affected, excites infection；5 grades refer to death.
The specific using method of used by tumor patients skin repair of the present invention breast is：The skin lighter for symptom, can be
Body delicate skin position (such as face, shirtfront, oxter) uses 2-3 time daily.During for 1 grade, 2 grades of fash occur, can apply
The place that goes wrong is put on, at least 3 times daily, is continuously used, or, while maintenance breast skin care is used for multiple times daily, coordinate anti-
Give birth to taking for plain or steroid drugs (following the doctor's advice).
The use range of the used by tumor patients skin repair breast of the present invention：Can be used for the lighter skin of asymptomatic or symptom,
As Preventive Nursing, strengthen skin-tolerant；When there is 1 grade, 2 grades of fash, skin repair and remission are carried out, coordinated
The use of antibiotic, steroid drugs (following the doctor's advice), strengthens skin adaptability.
Furfur, tortoise that the skin problem that the used by tumor patients skin repair breast of the present invention is suitable for causes including dry skin
Split, the itch that dermatitis causes, and the pain that skin turgor causes.
The used by tumor patients skin repair breast of the present invention is natural plant extraction elite, it is adaptable to whole body skin everywhere,
And product is verified by dermal sensitivity test, it is adaptable to sensitive skin.
The used by tumor patients skin repair breast of the present invention can strengthen skin Preventive Nursing, delaying skin malaise symptoms,
Strengthen skin nursing, reduce the risk that 3 grades of dermoreactions occur.
Additionally, for the skin treating problem design clinical testing in current cancer therapies, being made from vitamin E milky lotion
For control, reference substance is without hormone, antibiotic etc composition.By clinical testing it is more of the invention skin repair spraying with
The mitigation of skin problem of the vitamin E milky lotion to being caused due to medicine irritation in tumor therapeutic procedure, and to skin
The retarding action of deterioration progress, to seek more safely and effectively method, strengthens the compliance of patient's treatment, while strengthen suffering from
Person treats the confidence of disease.
Clinical testing：
1st, subjects
This test enters altogether group 40 and is diagnosed as Patients with Non-small-cell Lung, and patient's pathology is gland cancer.KPS scores 70
More than point, wherein treatment group 20, age 26-70 year, average age 51 years old, the male sex 8, women 12；Control group 20, year
Age 30-78 year, average age 62 years old, the male sex 11, women 9.
Treatment group and control group age statistics P=0.162>0.05, sex statistics X2=1.68, P=0.1945>0.05,
Clinical symptoms count Z=-0.473, P=0.636>0.05, enter fash classification before group patient's treatment and be shown in Table 3, Z=-0.819, P=
0.413>0.05, enter group patient oral epidermal growth factor recipient tyrosine kinase inhibitor (epidermal growth
Factor receptor tyrosine kinase inhibitors, EGFR-TKIs) medicament categories distribution be shown in Table 4, with oral
At most, medication situation is contrasted the patient of Gefitinib between two groups, P>0.05, and count disease KPS by stages and patient body situation
Scoring, P values are all higher than 0.05, and result above is represented without obvious significant difference between treatment group and control group, and baseline is steady, tool
There is comparativity.
Wherein, the skin repair breast described in treatment group's external application embodiment one carries out skin nursing, control group external application vitamin E
Milky lotion carries out skin nursing.
1.1 fash grade scales
The dermoreaction of table 2 is classified
1.2 are classified situation using front fash
Table 3 uses front patient's fash difference classification number
| 0 grade | 1 grade | 2 grades | 3 grades | 4 grades | 5 grades | It is total | |
| Treatment group | 13 | 6 | 1 | 0 | 0 | 0 | 20 |
| Control group | 15 | 3 | 2 | 0 | 0 | 0 | 20 |
Note：Jing statistical analysis, Z=-0.819, P=0.413>0.05, illustrate that two groups of patients use front in fash number of cases
No difference of science of statistics in distribution.
1.3 experimenter's medicines are counted using species
The patient of table 4 is distributed using EGFR-TKIs medicament categories
| Gefitinib | Tarceva | Conmana | It is total | |
| Treatment group | 14 | 4 | 2 | 20 |
| Control group | 15 | 3 | 2 | 20 |
Note：Two groups of medication statistical distributions P>0.05, statistics no significant difference.
2nd, using effect statistics
2.1 using fash clinical symptoms statistics after 15 days
Table 5 uses patient's fash difference classification number after 15 days
| 0 grade | 1 grade | 2 grades | 3 grades | 4 grades | 5 grades | It is total | |
| Treatment group | 8 | 10 | 2 | 0 | 0 | 0 | 20 |
| Control group | 5 | 15 | 2 | 0 | 0 | 0 | 20 |
2.2 using fash clinical symptoms statistics after 30 days
Table 6 uses the different classification numbers of fash clinical symptoms statistics after 30 days
| 0 grade | 1 grade | 2 grades | 3 grades | 4 grades | 5 grades | It is total | |
| Treatment group | 9 | 8 | 3 | 0 | 0 | 0 | 20 |
| Control group | 0 | 7 | 10 | 3 | 0 | 0 | 20 |
2.3 using fash clinical symptoms statistics after 60 days
Table 7 uses the different classification numbers of fash clinical symptoms statistics after 60 days
| 0 grade | 1 grade | 2 grades | 3 grades | 4 grades | 5 grades | It is total | |
| Treatment group | 2 | 5 | 8 | 5 | 0 | 0 | 20 |
| Control group | 0 | 0 | 8 | 12 | 0 | 0 | 20 |
3rd, conclusion
In to EGFR-TKIs drug treatments, there are fash feelings using the patient of the skin repair breast of the present invention
The statistics of condition, showing the skin repair breast of the preventive use present invention can effectively delay the time of fash generation, effectively suppress
The menace level that fash occurs, effectively improves the tolerance degree of patient skin.
Above content is only presently preferred embodiments of the present invention, for one of ordinary skill in the art, according to the present invention's
Thought, will change in specific embodiments and applications, and this specification content should not be construed as to the present invention
Restriction.
Claims (10)
1. a kind of used by tumor patients skin repair is newborn, it is characterised in that be made up of the raw material of following mass percent：
Alcohols NMF 3%-10%, cocoa seed fat 5%-10%, the poly- certain herbaceous plants with big flowers alkene 3%-6% of hydrogenation, hydrolytic collagen 1%-10%, Huang
A kind of reed mentioned in ancient books extract 0.2%-2%, Fructus Citri grandis extract 0.5%-3%, extractive of perilla 0.5%-5%, Gotu Kola P.E 0.5%-
2.5%th, Radix et Caulis Opuntiae Dillenii extract 0.5%-3.5%, Rhizoma Smilacis Glabrae extract 0.5%-2.5%, long and thin hot pepper berry extract 0.2%-2%,
Pasque flower extract 0.5%-2%, palpus extractive of usnea 0.5%-4%, ginger-root extract 0.01%-1%, bisabolol
0.1%-2%, emulsifying agent 3.6%-12%, panthenol 0.5%-5%, allantoin 0.1%-1%, hyaluronic acid 0.01%-1.5%
And the water of surplus.
2. used by tumor patients skin repair as claimed in claim 1 is newborn, it is characterised in that the alcohols NMF includes fourth two
Alcohol, glycerine and propane diols.
3. used by tumor patients skin repair as claimed in claim 2 is newborn, it is characterised in that the emulsifying agent includes cetearyl alcohol
Base glucoside, cetanol, stearyl alcohol and cetostearyl alcohol.
4. used by tumor patients skin repair as claimed in claim 3 is newborn, it is characterised in that by the raw material of following mass percent
Composition：
Butanediol 2%-4.5%, glycerine 1%-2.5%, propane diols 1%-2.5%, cocoa seed fat 6%-8%, the poly- certain herbaceous plants with big flowers alkene of hydrogenation
4%-5%, hydrolytic collagen 3%-7%, Baical Skullcap root P.E 0.3%-1%, Fructus Citri grandis extract 1%-2.5%, extractive of perilla
1%-2%, Gotu Kola P.E 1%-2%, Radix et Caulis Opuntiae Dillenii extract 1%-3%, Rhizoma Smilacis Glabrae extract 1%-2%, prickly ash berries are carried
Take thing 0.22%-0.5%, pasque flower extract 1%-1.8%, palpus extractive of usnea 1.5%-3.5%, ginger-root extract
0.03%-0.08%, bisabolol 0.12%-0.17%, cetearyl glucoside 0.2%-0.5%, cetanol 2%-
3%th, stearyl alcohol 1.5%-2.5%, cetostearyl alcohol 1.4%-2%, panthenol 2.5%-3.5%, allantoin 0.3%-0.8%,
The water of hyaluronic acid 0.05%-1% and surplus.
5. used by tumor patients skin repair as claimed in claim 4 is newborn, it is characterised in that by the raw material of following mass percent
Composition：
Butanediol 4%, glycerine 2%, propane diols 2%, cocoa seed fat 7%, the poly- certain herbaceous plants with big flowers alkene 4.5% of hydrogenation, the hydrolytic collagen 5%, root of large-flowered skullcap
Extract 0.5%, Fructus Citri grandis extract 2%, extractive of perilla 1.2%, Gotu Kola P.E 1.5%, Radix et Caulis Opuntiae Dillenii extract 2%,
Rhizoma Smilacis Glabrae extract 1.3%, long and thin hot pepper berry extract 0.3%, pasque flower extract 1.2%, must extractive of usnea 2.5%,
Ginger-root extract 0.05%, bisabolol 0.15%, cetearyl glucoside 0.3%, cetanol 2.4%, stearyl alcohol 2%,
The water of cetostearyl alcohol 1.5%, panthenol 3%, allantoin 0.5%, hyaluronic acid 0.08% and surplus.
6. a kind of preparation method newborn for preparing used by tumor patients skin repair as described in any one of claim 1-5, its
It is characterised by, comprises the steps：
S1, A phases raw material is added and stirred in emulsion tank, and heated；
S2, B phases raw material is added and stirred in oil phase tank, and heated；
S3, by B phases raw material add emulsion tank in, emulsifying；
C phase raw materials are added after S4, cooling, is stirred；
S5, cooling inspection, it is qualified after discharging, it is filling.
Wherein, the A phases raw material includes butanediol, glycerine, propane diols, allantoin and water；
The B phases raw material includes cocoa seed fat, hydrogenates poly- certain herbaceous plants with big flowers alkene and emulsifying agent；
The C phases raw material includes the mixed of hydrolytic collagen, the mixed liquor that Baical Skullcap root P.E and water are formed, Fructus Citri grandis extract and water formation
Close liquid, the mixed liquor that extractive of perilla and water are formed, the mixed liquor that Gotu Kola P.E and water are formed, Radix et Caulis Opuntiae Dillenii extract and water
The mixed liquor that the mixed liquor of formation, Rhizoma Smilacis Glabrae extract and water are formed, butanediol, long and thin hot pepper berry extract, pasque flower are extracted
The mixture of the mixed liquor that thing, palpus extractive of usnea are mixed to form, ginger-root extract and bisabolol, panthenol, hyaluronic acid, with
And water.
7. the preparation method of used by tumor patients skin repair as claimed in claim 6 breast, it is characterised in that in S1, heating
To in the range of 83 DEG C -87 DEG C；In S2, it is heated in the range of 83 DEG C -87 DEG C；In S3, the temperature of emulsifying is 80
℃-85℃；In S4, it is cooled in the range of 43 DEG C -47 DEG C；In S5, it is cooled in the range of 33 DEG C -37 DEG C；
Preferably, in S1,85 DEG C are heated to；In S2,85 DEG C are heated to；In S3, the temperature of emulsifying is 83 DEG C；
In S4,45 DEG C are cooled to；In S5,35 DEG C are cooled to.
8. the preparation method of used by tumor patients skin repair as claimed in claim 6 breast, it is characterised in that also wrapped before S1
Include following steps：
S0, C phase raw materials are stirred it is standby.
9. the preparation method of used by tumor patients skin repair as claimed in claim 6 breast, it is characterised in that in S5, inspection
The first parameter include the hydrolytic collagen, Baical Skullcap root P.E, Fructus Citri grandis extract, extractive of perilla, the centella that contain in maintenance breast
Extract, Radix et Caulis Opuntiae Dillenii extract, Rhizoma Smilacis Glabrae extract, long and thin hot pepper berry extract, pasque flower extract, must extractive of usnea,
Ginger-root extract, bisabolol, panthenol, allantoin, hyaluronic acid account for respectively the mass percent of total amount.
10. the preparation method of used by tumor patients skin repair as claimed in claim 6 breast, it is characterised in that in S5, inspection
The second parameter be maintenance breast in microorganism content.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710124237.4A CN106620633A (en) | 2017-03-03 | 2017-03-03 | Skin repairing cream for tumor patients and preparation method of skin repairing cream |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710124237.4A CN106620633A (en) | 2017-03-03 | 2017-03-03 | Skin repairing cream for tumor patients and preparation method of skin repairing cream |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106620633A true CN106620633A (en) | 2017-05-10 |
Family
ID=58846878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710124237.4A Pending CN106620633A (en) | 2017-03-03 | 2017-03-03 | Skin repairing cream for tumor patients and preparation method of skin repairing cream |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106620633A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213095A (en) * | 2017-06-29 | 2017-09-29 | 芜湖凌梦电子商务有限公司 | A kind of net acne maintenance breast of oil-control |
| CN109077973A (en) * | 2018-08-25 | 2018-12-25 | 广东芭薇生物科技股份有限公司 | Two doses of carbonic acid foam masks of one kind and preparation method thereof and application method |
| CN113876645A (en) * | 2020-07-01 | 2022-01-04 | 伽蓝（集团）股份有限公司 | Usnea barbata extract, application thereof and skin external preparation containing Usnea barbata extract |
-
2017
- 2017-03-03 CN CN201710124237.4A patent/CN106620633A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 华生基因的博客: "《新浪博客》", 17 November 2016 * |
| 吉贝生活: "《吉贝生活》", 27 January 2016 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213095A (en) * | 2017-06-29 | 2017-09-29 | 芜湖凌梦电子商务有限公司 | A kind of net acne maintenance breast of oil-control |
| CN109077973A (en) * | 2018-08-25 | 2018-12-25 | 广东芭薇生物科技股份有限公司 | Two doses of carbonic acid foam masks of one kind and preparation method thereof and application method |
| CN113876645A (en) * | 2020-07-01 | 2022-01-04 | 伽蓝（集团）股份有限公司 | Usnea barbata extract, application thereof and skin external preparation containing Usnea barbata extract |
| CN113876645B (en) * | 2020-07-01 | 2024-01-05 | 伽蓝（集团）股份有限公司 | Usnea barbata extract, application thereof and skin external preparation containing same |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6027728A (en) | Herbal skin regeneration composition and method | |
| CN107737041A (en) | A kind of novel skin antiallergic maintenance composition, skin repair frost and preparation method thereof | |
| CN102091203A (en) | External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof | |
| KR101412500B1 (en) | Cosmetic composition for improving atopic skin comprising herb extract fermented in bamboo cylinder and manufacturing method thereof | |
| CN104013878B (en) | A kind of lavipeditum medicine vinegar and preparation method thereof for treating tinea pedis | |
| CN106620633A (en) | Skin repairing cream for tumor patients and preparation method of skin repairing cream | |
| KR20220168132A (en) | Composition for skin containing pine bark extract having edema relief, cellulite reduction and whitening effects, and skin cream using the same | |
| CN109939193A (en) | A kind of composition for treating skin eczema, preparation and preparation method and application | |
| CN109303724A (en) | A kind of novel maintenance stoste composition of releiving containing folium artemisiae argyi | |
| CN108379350A (en) | A kind of eczema ointment and preparation method thereof | |
| CN115518127B (en) | Antibacterial, anti-inflammatory, detumescence and antipruritic cream and preparation method thereof | |
| CN106853204A (en) | Used by tumor patients skin repair spraying and preparation method thereof | |
| CN106344460A (en) | Special moisturizing and acne-removing face cream for acne-prone skin and preparation method thereof | |
| KR20210075420A (en) | Composition for attenuating pain containing complex natural hub extracts | |
| CN105213584A (en) | A kind of Chinese medicine composition for the treatment of eczema and preparation method thereof | |
| CN102626471B (en) | Traditional Chinese medicine composition with effects of anti-anaphylaxis, desensitization, repair and regeneration | |
| CN111450165A (en) | Traditional Chinese medicine composition for treating beriberi and preparation method thereof | |
| CN101953951B (en) | Hand and feed health-care and beautifying liquid and preparation method thereof | |
| CN106466261A (en) | Health preserving skin care compositionss | |
| CN109924553A (en) | A kind of Chinese herbal medicine socks for preventing and treating tinea pedis | |
| CN109157426A (en) | A kind of skin-care agent and preparation method thereof containing 4- terpinol | |
| CN116570700B (en) | Traditional Chinese medicine preparation with antibacterial, anti-inflammatory and acne removing effects and application thereof | |
| CN114259517B (en) | Traditional Chinese medicine aromatherapy gel for treating allergic rhinitis | |
| CN111700989B (en) | Traditional Chinese medicine composition for dispelling wind, eliminating dampness and treating tinea pedis and preparation method thereof | |
| CN109568182B (en) | Tea oil soothing cream for children |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170510 |
|
| RJ01 | Rejection of invention patent application after publication |