CN116570700B - Traditional Chinese medicine preparation with antibacterial, anti-inflammatory and acne removing effects and application thereof - Google Patents

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine preparation with antibacterial, anti-inflammatory and acne removing effects and application thereof. Specifically, the traditional Chinese medicine preparation with antibacterial, anti-inflammatory and acne removing effects comprises the following active pharmaceutical ingredients in parts by weight: 1-5 parts of fructus evodiae, 2-10 parts of Chinese angelica, 1-5 parts of ligusticum wallichii, 1-5 parts of poria cocos, 2-10 parts of cassia twig, 3-15 parts of radix paeoniae alba, 1-5 parts of rhizoma sparganii, 1-5 parts of rhizoma curcumae, 2-10 parts of safflower, 1-5 parts of peach kernel, 1-5 parts of pinellia ternate and 2-5 parts of radix ophiopogonis. Furthermore, the traditional Chinese medicine preparation can also be used for preparing external medicines. Experiments prove that the product has the advantages of high efficiency, rapid acne removal, tissue repair, skin immunity improvement and high safety, and therefore has good practical application value.

Description

Traditional Chinese medicine preparation with antibacterial, anti-inflammatory and acne removing effects and application thereof

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine preparation with antibacterial, anti-inflammatory and acne removing effects and application thereof.

Background

The disclosure of this background section is only intended to increase the understanding of the general background of the invention and is not necessarily to be construed as an admission or any form of suggestion that this information forms the prior art already known to those of ordinary skill in the art.

Acne is also known as "vaccinia," a chronic inflammatory skin disease that is well developed in the pilo-sebaceous unit of the human face, with prevalence at position 8 worldwide. Acne marks are manifested by damaged local skin barriers, inflammatory pigmentation, severe acne scars, etc. It was found that more than 95% of people had varying degrees of acne, and 3% -7% of acne patients had scars, affecting the appearance and physical and mental health of the patients. Its main etiology is as follows: (1) sebaceous gland hyperfunction caused by abnormal androgen secretion; (2) abnormal keratinization of hair follicles; (3) bacterial abnormal proliferation, commonly known as Propionibacterium acnesP. acnes) Staphylococcus aureus @ sS. aureus) Etc., most hazardous isP. acnesThe method comprises the steps of carrying out a first treatment on the surface of the (4) Inflammation. Acne may be inflammatory or non-inflammatory. Non-inflammatory lesions are also known as comedones, including blackheads (open comedones) and whiteheads (closed comedones). Most of inflammatory lesions develop from acne, propionibacterium acnes induce local inflammatory reaction of skin, so that acne wall is broken, discharged contents enter dermis to generate local inflammatory reaction again, and finally the structure of pilosebaceous glands is destroyed, and erythema is left, pigmentation or scar is often generated even after inflammation is eliminated.

The clinical treatment means for acne patients mainly comprise external medicines (such as tretinoin and benzoyl peroxide), oral medicines (such as antibiotics and hormone), physical treatments (such as red blue light, laser and radio frequency), chemical stripping (if acid and salicylic acid), traditional Chinese medicine treatments (including internal treatment and external treatment), and the like. Although the current medicine has obvious curative effect on acne, the toxic and side effects are not quite small, such as allergy, kidney function damage, even malformation and the like. Thus, searching for drugs or cosmetics that are safe and effective for treating acne is a research hotspot. The acne-removing external medicine is a common and effective tool for treating acne, and the existing acne-removing raw materials are various in variety and uneven in product quality, so that reasonable selection and compounding of raw materials have important effects when the acne-removing preparation is developed according to the pathogenesis of acne and characteristics of different raw materials.

Traditional Chinese medicine is a hot trend in the development of acne treatment all the time by virtue of the mild and safe characteristics. According to ancient Fang Duo recorded by classical medical books for treating acne, the traditional Chinese medicine mainly has the effects of clearing heat and detoxicating, resolving masses and detumescence, dispelling wind and removing dampness and removing blood stasis, and the modern clinical external medicine for treating acne mainly has the effects of clearing heat and detoxicating, activating blood and removing obstruction in collaterals, and reducing phlegm and removing dampness.

According to Huangdi's interior channel, lingqiu: the tenth stomach-foot-yangming pulse of the meridian starts from the point of the nose, the side of the pulse of the sun, the lower circulation is outside the nose, the upper circulation enters the teeth, the mouth pinching ring lip, the lower circulation is used for carrying pulp, the lower circulation is cheap, the upper circulation is welcome, the lower circulation is used for carrying the cheek, the upper ear is in front of the passenger, the host is used for carrying the hair to the forehead; the patient who receives the light from the front of the big head receives the light, the throat is in the absence of the basin, and the lower diaphragm pertains to the stomach, collaterals and spleen; the patient who is straight, who is low in milk from the lack of basin, is attached to the umbilicus and enters the qi street; the patient starts from the stomach opening, runs down the abdomen, runs down the qi street and merges with the stomach, runs down the thigh, runs against the rabbit, runs down the knee in the knee, runs down the outer part of the tibia, runs down the tarsal region, runs into the middle finger and the middle finger; for those with branch, three cun below, the lower one is placed in the middle-finger space; its branch is marked by the fact that it enters the middle of the big finger and exits its tip. The disease is caused by movement, the disease is caused by sprinkling and shaking cold, the disease is caused by groan and is caused by lack of vigor, the disease is caused by bad people and fire, the smell of wood is caused by vigilance, the heart is intended to move, the user is closed singly, the user is in the place of the user's head, the user is even required to get up and singe, the user is required to discard the clothing and walk, the heart sounds and the abdominal distention are syncope. Is a patient with primary blood disease, and has symptoms of warm malaria, hemorrhage due to sweats, gizzard with lip and mouth, neck swelling and sore throat, edema of the large abdomen, swelling and pain of the knee and the leg, pain of the foot and the tarsal bone due to the circulation of blood, milk, qi streets, thigh, lying rabbit, external cheat, and pain of the middle finger. Excessive qi is warm before it is, if it is left in the stomach, it will promote the digestion and hunger, and it will be yellow. Deficient qi may lead to cold chestnut before the body is full of stomach cold. For these reasons, excessive heat is used to purge, deficient heat is used to supplement, cold is used to leave, and excessive heat is used to treat the excessive heat. The patients with excessive people are three times larger than cun-kou and the patients with deficiency people are smaller than cun-kou.

The stomach meridian of foot yangming can be used for walking on the face of human body, for example, if stomach meridian is not descending, the face is acne, etc. the face is pimpled in front of human body. The disease is caused by main blood, is the main and the action as if two people fight, the strong fight the weak, the disease is the "action" when the strong fights the weak, the healthy qi attacks the external pathogenic qi, the disease is the "main" when the weak is injured and continuously groan, the disease is the "main", and the healthy qi can not resist the pathogenic qi, and the healthy qi can be used for the blood supply. The stomach of foot-yangming absorbs and eats food and turns into qi and blood, spleen moves and transforms qi and blood to nourish the whole body, yangming channels descend and discharge metabolism, and when normal metabolism can not discharge, qi diseases are in channels, and blood is accumulated into pimples. When qi and blood are not nourished, facial spots, acne marks and the like are caused. Through the analysis, the facial acnes, the color spots and the like are related to the stomach meridian of the foot yangming, and the facial acnes and the color spots can be broken through by regulating the stomach meridian of the foot yangming. The medicine is processed into paste capable of being absorbed by the face, stimulates the stomach meridian point of the foot yangming, improves the operation of qi and blood of channels and collaterals, ensures that the paste staying on the face is removed from the body, and achieves the aim of improving acnes, acne marks, acnes and spots on the face of a human body.

Along with the continuous enhancement of the health concept of people, the demand for safe and effective acne-removing products is also increasing. At present, most acne-removing raw materials generally have the problems of low effective rate, poor skin tolerance, single action mechanism and the like, and based on the current research situation of acne pathology, the novel natural compound acne-removing raw materials are used for adjusting the stomach meridian and face acupoints so as to break up skin problems such as facial acne, acne marks, acnes, spots and the like.

Disclosure of Invention

Aiming at the defects of the prior art, the invention aims to provide a traditional Chinese medicine preparation with antibacterial, anti-inflammatory and acne removing effects and application thereof. Aiming at the treatment of acne, based on the traditional Chinese medicine theory and the clinical experience of the inventor for years, the traditional Chinese medicine preparation with the effects of bacteriostasis, anti-inflammation and acne removal is developed, and has good practical application value.

In order to achieve the above purpose, the present invention adopts the following technical scheme:

the invention provides a traditional Chinese medicine preparation with antibacterial, anti-inflammatory and acne removing effects, which comprises the following active pharmaceutical ingredients in parts by weight:

1-5 parts of fructus evodiae, 2-10 parts of Chinese angelica, 1-5 parts of ligusticum wallichii, 1-5 parts of poria cocos, 2-10 parts of cassia twig, 3-15 parts of radix paeoniae alba, 1-5 parts of rhizoma sparganii, 1-5 parts of rhizoma curcumae, 2-10 parts of safflower, 1-5 parts of peach kernel, 1-5 parts of pinellia ternate and 2-5 parts of radix ophiopogonis.

Specifically, the traditional Chinese medicine preparation can contain pharmaceutically acceptable auxiliary materials and/or carriers besides the active ingredients.

More specifically, the preparation method of the traditional Chinese medicine preparation comprises the following steps: weighing the corresponding raw materials according to the parts by weight, and crushing the raw materials into fine powder for later use.

In a second aspect of the invention, the application of the traditional Chinese medicine preparation in preparing a product with antibacterial, anti-inflammatory and acne removing effects is provided.

The product may be a pharmaceutical product.

Further, the medicine is an oral medicine or an external medicine, preferably an external medicine.

In a third aspect, the invention provides a product with antibacterial, anti-inflammatory and acne removing effects, which at least comprises the traditional Chinese medicine preparation in the first aspect.

The product is a medicine.

In one embodiment of the present invention, the pharmaceutical product is an oral or topical drug, preferably an external drug.

In particular, the dosage form of the external medicine can be solution (namely, aqueous solution of medicine), powder, emulsion, ointment, paste (mud) paste, film coating agent, aerosol or gel. For example, the Chinese medicinal preparation disclosed in the above first aspect of the present invention is mixed with pharmaceutical excipients and/or carriers, and the resulting mixture is formed into a desired shape or state. In addition to the present invention, the preparation of pharmaceutical formulations may also be carried out according to modern pharmaceutical formulation books of the university of Shenyang pharmacopoeia. And, in addition to the present invention, suitable pharmaceutical excipients and/or carriers are known in the art, for example, see the pharmaceutical excipients handbook of 2005 edition (original fourth edition), authors: R.C. Siro; p.j. seryl.

In one embodiment of the present invention, there is provided a method of using the above product, the method comprising: mixing above materials with ovum gallus Domesticus album, applying to affected part skin for a certain period (half an hour per day), and cleaning with warm water.

Compared with the prior art, the technical scheme of the invention has the following beneficial effects:

1. the traditional Chinese medicine preparation takes evodia rutaecarpa and pinellia ternate as monarch drugs, warms channels and dispels cold, eliminates dampness and eliminates stagnation, relieves the stagnation of yang, takes angelica sinensis, ligusticum chuanxiong, peach kernel, safflower, rhizoma sparganii and rhizoma curcumae as ministerial drugs, cooperates with monarch drugs to strengthen the effects of activating blood circulation and dissolving stasis, promoting qi circulation and removing obstruction in collaterals, takes poria cocos, cassia twig, radix paeoniae alba and radix ophiopogonis as adjuvant, obtains the property of nourishing yin and moistening of radix paeoniae alba and radix ophiopogonis while promoting perspiration and removing dampness, and takes radix ophiopogonis and pinellia ternate as guiding drugs to enter channels, can obviously inhibit the proliferation of staphylococcus aureus and propionibacterium acnes after being used for guiding the drugs to the stomach channels of foot yang, has good effects of improving skin inflammation and removing acnes of a plurality of testers, exerts the effects of bacteriostasis, diminishing inflammation and removing acnes, has good stability, can be stored for a long time, and has clinical application to prove the safety and effectiveness of the traditional Chinese medicine preparation.

2. High-efficient quick acne removal: the pure natural traditional Chinese medicine composition can improve slow metabolism of the face, enhance blood flow operation and enable acnes, acne marks, acnes, spots and the like to be metabolized rapidly.

3. Tissue repair and improve skin immunity: repairing damaged tissues of skin epithelial layers, removing acnes and leaving no scar; at the same time, the skin immunity is improved, and skin allergy and acne regeneration are reduced.

4. High security: the invention adopts natural components to the maximum extent, has no acne, no skin injury, no irritation, no allergy, no antibiotics and hormone, and can not generate drug resistance after long-term use. Aiming at the physiological and pathological characteristics of skin, the acne skin is comprehensively nursed in the whole process through sterilization, anti-inflammation, repair, regeneration, immunity improvement and the like.

Detailed Description

It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the present invention. As used herein, the singular forms also are intended to include the plural forms unless the context clearly indicates otherwise, and furthermore, it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, and/or combinations thereof.

As described in the background art, the medicine for treating acne in the prior art has a certain defect, and in order to solve the technical problems, the invention is based on the core formula with good curative effect, which is prepared by adjusting the acupoints on the stomach meridian and face of foot yangming by using novel natural compound acne-removing raw materials, is based on the traditional Chinese medicine theory of China and integrates the clinical experience of the inventor for many years aiming at the treatment of acne.

In view of the above, in an exemplary embodiment of the present invention, a Chinese medicinal preparation for inhibiting bacteria, diminishing inflammation and removing acne is provided, wherein the active pharmaceutical ingredients of the Chinese medicinal preparation comprise the following raw materials in parts by weight:

1-5 parts of fructus evodiae, 2-10 parts of Chinese angelica, 1-5 parts of ligusticum wallichii, 1-5 parts of poria cocos, 2-10 parts of cassia twig, 3-15 parts of radix paeoniae alba, 1-5 parts of rhizoma sparganii, 1-5 parts of rhizoma curcumae, 2-10 parts of safflower, 1-5 parts of peach kernel, 1-5 parts of pinellia ternate and 2-5 parts of radix ophiopogonis.

In another specific embodiment of the invention, the pharmaceutical active ingredient comprises the following bulk drugs in parts by weight:

1 part of evodia rutaecarpa, 2 parts of angelica sinensis, 1 part of ligusticum wallichii, 1 part of poria cocos, 2 parts of cassia twig, 3 parts of white paeony root, 1 part of rhizoma sparganii, 1 part of rhizoma curcumae, 2 parts of safflower, 1 part of peach kernel, 1 part of pinellia ternate and 2 parts of radix ophiopogonis.

In practical application, the traditional Chinese medicine preparation can be modified in clinical practice, for example, if the skin is dry and yellow and dark, 1-2 parts of peach kernel, 1-2 parts of safflower and 2-5 parts of dwarf lilyturf tuber can be added for patients with obvious color spots.

If acne is red, the acne mark is obvious, 1-3 parts of rhizoma sparganii, 1-3 parts of rhizoma curcumae and 1-2 parts of pinellia ternate can be added.

If the acne is more, 1-3 parts of evodia rutaecarpa, 1-3 parts of angelica sinensis, 2-5 parts of poria cocos, 1-3 parts of cassia twig and 1-3 parts of white paeony root can be added for patients with red skin itching.

The above raw materials may be ground into fine powder for external use or decocted for oral administration, and are not particularly limited herein.

The specific effects of the active ingredients and the raw material medicines are as follows:

evodia rutaecarpa: shennong Ben Cao Jing (Shennong's herbal medicine book): mainly warming middle-jiao and descending qi, relieving pain, relieving cough, relieving cold and heat, removing dampness, relieving blood arthralgia, expelling pathogenic wind, and opening striae. "Evodiamine contained in it can inhibit skin oxidation induced by ultraviolet rays, and Matrix Metalloproteinases (MMPs) contained in it are the main enzymes for degrading collagen in skin. Skin is irradiated with ultraviolet light to induce oxygen radical generation, which activates MMPs (mainly MMP2 and MMP-9), resulting in collagen degradation, thereby generating wrinkles (photoaging). Evodiamine can inhibit the generation of oxygen white radical induced by ultraviolet irradiation, reduce MMP2 and MMP-9 levels, and protect photoaging.

Chinese angelica root: shennong Ben Cao Jing (Shennong's herbal medicine book): the cough with the adverse rise of qi, wen Nve, cold and heat, is washed in the skin. Women leak down the insulator, and the malignant ulcer is created. Boiled and drunk. One name is Ganmao. Raw Chuangu. Has effects of replenishing blood, nourishing blood, promoting blood circulation, removing blood stasis, regulating menstruation, relieving pain, and caring skin. The vitamin A, B, E and the beneficial trace elements contained in the food can be fully absorbed by human body, and the substances can improve the metabolism of the human body, help to timely discharge the waste such as redundant fat in the human body, and further make the skin glowing. The muscle atrophy is obviously delayed, the content of SOD in muscle tissues is increased, and the mechanism of the muscle atrophy is possibly related to the promotion of muscle blood circulation and the improvement of metabolism by Chinese angelica. The Angelica sinensis polysaccharide has good antiaging effect, and ASP can antagonize spleen atrophy, enhance SOD activity of serum and brain tissue, reduce MDA content, and improve CSH-PX activity.

Ligusticum wallichii: the "Rihua Zi Ben Cao" describes: treat all wind, all qi, all strain and all blood. Tonifying five strains, strengthening tendons and bones, regulating pulse, breaking and treating stagnation, nourishing blood, growing meat, nose Hong Tuxie and drowning blood, hemorrhoids and fistula, cerebral carbuncles, hair backs, scrofula, gall, scabies, pus discharge and blood stasis. Has the effects of promoting blood circulation, promoting qi circulation, dispelling pathogenic wind, retaining youthful looks, removing speckle, etc., and contains various alkaloids such as ligustrazine, phenols such as ferulic acid, volatile oil, vitamins, etc. Ligustrazine can dilate blood vessels, reduce vascular resistance and obviously increase blood flow of limbs; has inhibiting effect on various pathogenic bacteria and viruses; has vitamin E deficiency resisting effect. Ligustrazine has effects of inhibiting cell proliferation, melanin synthesis, and tyrosinase activity for melanocytes cultured in vitro. Has good regulation effect on microcirculation system, and the water extract has strong inhibition effect on some pathogenic dermatophytes. Can also inhibit tyrosinase activity, thereby having therapeutic effect on black spots, freckle and senile plaque. Can increase skin metabolism, skin elasticity, resist wrinkle and aging, and make skin soft and moist; can inhibit dermatitis and enhance skin resistance; can neutralize released histamine and has antiallergic effect.

Poria cocos: the Chinese medicinal composition is originally carried in Shennong Ben Cao Jing, has sweet taste and flat nature, returns to heart, spleen and lung meridians, and has the effects of excreting dampness, tonifying spleen and stomach, harmonizing middle energizer and relieving vomiting, calming heart and developing intelligence, reducing the adverse flow of qi, nourishing yin and promoting the production of body fluid, and the like. The triterpene compound is a main component with anti-inflammatory effect, achieves the anti-inflammatory effect by inhibiting phospholipase, effectively eliminates superoxide anion free radical, hydroxyl free radical and hydrogen peroxide, and has dose dependency between the clearance rate and the mass concentration; further in vitro antioxidation experiments show that the poria peel triterpene has the effects of inhibiting the hemolysis of chicken erythrocytes and has a good effect of removing MDA generated by the peroxidation of mouse liver lipid. Pachyman also has antioxidant effect. Can be used for preventing skin inflammation, resisting oxidation, and slowing down aging.

Ramulus Cinnamomi: shennong Ben Cao Jing (Shennong's herbal medicine book): pungent and warm in flavor. Cough with dyspnea, obstruction of qi in the throat, vomiting and suction, benefiting joints, strengthening middle-jiao and replenishing qi. The long-term taking of the medicine can activate the spirit and keep the weight small. The product has effects of relieving muscle and sweating, harmonizing nutrient and defensive qi, stimulating sweat gland secretion, enhancing blood circulation, promoting blood flow to body surface, dilating skin blood vessel, promoting sweating, and inhibiting various bacteria in vitro, with effective concentration of 25mg/mL. Such as Staphylococcus aureus, typhoid bacillus, escherichia coli, dysentery bacillus, cholera vibrio, bacillus subtilis, bacillus anthracis, dermatophyte, etc.

White peony root: shennong Ben Cao Jing (Shennong's herbal medicine book): bitter and flat taste. Abdominal pain due to pathogenic qi, removing blood obstruction, resolving hard mass, resolving cold and heat, treating hernia, relieving pain, promoting urination, and invigorating qi. Has the effects of nourishing blood, softening liver, relieving pain, astringing yin and sweat, and effectively improving the phenomena of rough skin, dark yellow, chloasma, pigmentation and the like caused by blood deficiency and cold; the radix Paeoniae alba extract TGP has antioxidant and cell membrane stabilizing effects, and has free radical scavenging effect. The alcohol extract can inhibit ADP, collagen and arachidonic acid induced rabbit platelet aggregation in vitro; meanwhile, the composition has extremely strong antibacterial effect.

Triangular prism: first, the method is carried out in Ben Cao Shi Yi (materia Medica of Tang Dynasty Chen Cangqi). It is bitter in flavor and enters liver and spleen meridians. The traditional Chinese medicine is recorded in the past as having the effects of breaking blood and promoting qi circulation, removing food retention and relieving pain, and can be used for treating abdominal mass, qi and blood stagnation, heart and abdomen pain, hypochondrium distending pain, amenorrhea, postpartum abdominal pain due to blood stasis, traumatic injury, sore and swelling, and the like. The medicine can inhibit ADP-induced platelet aggregation by being matched with the curcuma zedoary, and reduce the viscosity of whole blood; the rhizoma sparganii total flavone has strong platelet aggregation resistance and thrombus resistance, and the rhizoma sparganii extract has a certain function of promoting fibrinolysis in vitro, can balance the grease secretion of skin, dredge pores and remove skin endotoxin impurities.

Zedoary turmeric: the "Rihua Zi Ben Cao" describes: treating all qi, stimulating appetite, promoting digestion, dredging menstruation, removing blood stasis, stopping pain due to disturbance, and removing internal injury and aversion to blood. "functional promoting qi circulation, removing blood stasis, and relieving pain. Has antibacterial and antiviral effects with rhizoma Sparganii; zedoary turmeric oil and curcumenol have anti-fibrous tissue proliferation effect; the zedoary turmeric oil cream has effects of inhibiting keratinocyte proliferation and promoting keratinocyte normal differentiation; zedoary turmeric oil has effects of inhibiting leukemia cell growth and protecting normal hematopoietic cells; the different extracts of Curcumae rhizoma have effects of resisting platelet aggregation, resisting blood coagulation, and regulating blood rheology.

Safflower: the "Bencaozheng" describes: the heat of the up acne is difficult to go out, and the macula and blood stagnation are not eliminated. "Ben Cao gang mu" records: "activating blood, moistening dryness, relieving pain, dispersing swelling and dredging channels". Has effects in promoting blood circulation, dredging channels, removing blood stasis, relieving pain, caring skin, softening skin horny layer, dilating peripheral blood vessel, inhibiting platelet aggregation, enhancing fibrinolysis, and reducing viscosity of whole blood. Has antiinflammatory and immunosuppression effects. Inhibiting dermatitis, enhancing skin resistance, and preventing allergy.

Peach kernel: the description of Ben Cao gang mu: "its work has four: treating heat entering the blood chamber, also; diarrhea, abdominal stagnation and blood stagnation; removing heat and itching of skin blood; blood that condenses on the skin is also collected. Has effects of promoting blood circulation for removing blood stasis, moistening dryness, and smoothing intestine, and can be used for treating dysmenorrhea, amenorrhea, abdominal mass, traumatic injury, skin blood heat dryness and itching, blood stagnation and wind arthralgia. Semen Persicae contains a large amount of fatty oil for promoting blood circulation, removing blood stasis, loosening bowel to relieve constipation, relieving cough and asthma. Has effects in relieving inflammation, dilating blood vessel, inhibiting blood coagulation, resisting blood platelet aggregation, and reducing blood viscosity, and can be used for eliminating blood flow block, improving blood circulation disorder, and restoring skin tissue function. The specific mechanism is that the medicine has direct expansion effect on the vessel wall, increases the blood flow, inhibits platelet aggregation, has certain hemolysis effect, and has good curative effect on skin ulcer suppuration due to the anti-inflammatory effect.

Pinellia ternate: drug Property theory describes: "eliminate phlegm and saliva, promote appetite and invigorate spleen, stop vomiting, remove phlegm and fullness in chest, lower lung qi, and promote cough. The neonate can remove tumor and gall after treating carbuncle and swelling. "functional dry dampness and resolve phlegm, adverse rise of qi and arrest vomiting, relieve distension and fullness and dissipate nodulation, and external carbuncle and swelling; has antibacterial, antiinflammatory, and antioxidant pharmacological activities. Contains volatile oil, organic acid, and other compounds. The unsaturated fatty acid contained in the medicine can play a good role in treating chloasma due to the antioxidation effect; the amino acid and the grease contained in the skin-care cream have nutrition effect on the skin, so that the skin-care cream can moisten and whiten the skin.

Radix Ophiopogonis: the "Bencao Xin Ji" records: "replenishing essence and strengthening yin, relieving restlessness and quenching thirst, beautifying the color, nourishing skin and removing deficiency heat". "has effects of nourishing yin, moistening lung, clearing heart fire, relieving restlessness, invigorating stomach, and promoting salivation. The flavonoid compound is an effective free radical scavenger, can reduce accumulation of lipofuscin in cells, eliminate pigmentation of face, improve skin elasticity, reduce or eliminate facial wrinkles, moisten and tender face, and reduce or blacken white hair. The sterol has good permeability to skin, can maintain moisture on skin surface, promote skin metabolism, inhibit skin inflammation, and prevent sunburn erythema and skin aging. The iron can enhance hematopoiesis; manganese contained can participate in hematopoiesis, and skin is nourished from sufficient blood to moisten hair, so that hair can grow normally. The zinc contained in the composition can promote tissue regeneration and protect skin health. And can be used for treating skin eczema and acne. The copper contained can maintain the normal color and structure of skin and hair. Has better elimination effect on superoxide radicals, and is a good radical capturing agent; meanwhile, the composition has extremely strong antibacterial effect.

The synergistic traditional Chinese medicine composition can enhance the functions of the traditional Chinese medicine composition, such as the evodia rutaecarpa for heat-relieving, cold-dispelling and pain-relieving, the pinellia tuber for warming, dampness-eliminating and phlegm-resolving, adverse-rising energy-relieving vomiting and masses-relieving, and the compatibility of the two medicines enhances the dredging of channels and collaterals obstruction caused by qi and blood retrograde of the stomach channel of foot yangming; angelica sinensis Wen Buxie has effects of promoting blood circulation, and rhizoma Ligustici Chuanxiong Wen Hang has effects of resolving stagnation, dispelling pathogenic wind, removing dampness, promoting blood circulation and relieving pain. The three-edged Chinese medicinal composition has the effects of calming blood, promoting qi circulation, removing food retention, relieving pain, warming and activating qi-flowing, removing food retention, relieving pain, warming and activating blood, and dredging channels, dispelling blood stasis, relieving pain, warming and activating blood, and dispelling blood stasis, and the compatibility of the six can strengthen the effects of promoting blood circulation, removing blood stasis, and can quickly metabolize skin wastes caused by acne, acne marks, acnes, color spots and the like; ramulus Cinnamomi has effects of warming sweat, relieving exterior syndrome, dispelling cold, relieving pain, activating yang, activating qi-flowing, promoting diuresis, and can promote metabolism of hair pores to promote sweat; white peony root Wen Yangxie can regulate menstruation, astringe yin and arrest sweating, dwarf lilyturf tuber can nourish yin and promote the production of body fluid, and compatibility of the two medicines can astringe yin and nourish yin and lock skin moisture from excessively losing; in addition, the compatibility of the white paeony root and the cassia twig can also play a role in harmonizing nutrient and defensive qi and nourishing skin, and the oily components of the angelica and the peach kernel can fully moisten skin under the synergistic effect of the angelica and the peach kernel, and the compatibility of the rhizoma ligustici wallichii, the rhizoma sparganii, the rhizoma curcumae, the safflower and the fructus evodiae can warm and dredge blood vessels, activate blood and relieve pain, so that discomfort such as skin pain caused by acne and the like can be effectively improved, and the compatibility of the medicines can effectively improve the qi and blood circulation of channels and collaterals, so that the stasis of a human body can be removed from the body.

Therefore, the traditional Chinese medicine composition can effectively relieve acne, acne marks, acnes, spots and the like, and has safety and effectiveness.

In order to enable those skilled in the art to more clearly understand the technical scheme of the present invention, the technical scheme of the present invention will be described in detail with reference to specific embodiments.

Example 1

A Chinese medicinal composition for treating acne comprises the following medicinal active ingredients: 1 part of evodia rutaecarpa, 2 parts of angelica sinensis, 1 part of ligusticum wallichii, 1 part of poria cocos, 2 parts of cassia twig, 3 parts of white paeony root, 1 part of rhizoma sparganii, 1 part of rhizoma curcumae, 2 parts of safflower, 1 part of peach kernel, 1 part of pinellia ternate and 2 parts of radix ophiopogonis; mixing the above materials, and grinding into powder to obtain the final product.

Example 2

A Chinese medicinal composition for treating acne comprises the following medicinal active ingredients: 2 parts of evodia rutaecarpa, 3 parts of angelica sinensis, 1 part of ligusticum wallichii, 1 part of poria cocos, 2 parts of cassia twig, 3 parts of white paeony root, 1 part of rhizoma sparganii, 1 part of rhizoma curcumae, 1 part of safflower, 2 parts of peach kernel, 1 part of pinellia ternate and 2 parts of radix ophiopogonis; mixing the above materials, and grinding into powder to obtain the final product.

Example 3

A Chinese medicinal composition for treating acne comprises the following medicinal active ingredients: 1 part of evodia rutaecarpa, 3 parts of angelica sinensis, 1 part of ligusticum wallichii, 2 parts of poria cocos, 2 parts of cassia twig, 2 parts of radix paeoniae alba, 3 parts of rhizoma sparganii, 3 parts of rhizoma curcumae, 3 parts of safflower, 1 part of peach kernel, 2 parts of pinellia ternate and 2 parts of radix ophiopogonis; mixing the above materials, and grinding into powder to obtain the final product.

Example 4

A Chinese medicinal composition for treating acne comprises the following medicinal active ingredients: 1 part of evodia rutaecarpa, 1 part of angelica sinensis, 2 parts of ligusticum wallichii, 2 parts of poria cocos, 2 parts of cassia twig, 5 parts of white paeony root, 1 part of rhizoma sparganii, 1 part of rhizoma curcumae, 4 parts of safflower, 1 part of peach kernel, 1 part of pinellia ternate and 3 parts of radix ophiopogonis; mixing the above materials, and grinding into powder to obtain the final product.

Comparative example 1

Weighing 2 parts of angelica sinensis, 1 part of ligusticum wallichii, 1 part of poria cocos, 2 parts of cassia twig, 3 parts of white paeony root, 1 part of rhizoma sparganii, 1 part of rhizoma curcumae, 2 parts of safflower, 1 part of peach seed, 1 part of pinellia ternate and 2 parts of radix ophiopogonis; mixing the above materials, and grinding into powder to obtain the final product.

Comparative example 2

Grinding the raw materials into powder to form the acne-removing traditional Chinese medicine composition.

Example 5

A Chinese medicinal gel for treating acne is prepared by extracting effective components of Chinese medicinal materials by the following method, and preparing the preparation according to the following steps:

(1) Weighing 250g of the acne-removing traditional Chinese medicine composition in example 1 by using an electronic scale, crushing into coarse powder by using a crusher, sieving with a No. 1 screen, uniformly mixing, adding 15 times of distilled water, soaking for 30min, carrying out reflux extraction at a reduced pressure and low temperature for 3 times, wherein the extraction temperature is 70 ℃ each time, combining 3 times of extracting solutions, concentrating, placing in a stirrer, controlling the rotating speed to 40r/min, adding 95% ethanol according to the volume ratio of 5:1, and standing for 12h at a low temperature (-4 ℃), thus obtaining the acne-removing traditional Chinese medicine composition for standby.

(2) Centrifuging the system obtained in the step (1) for 8min at 4000r/min, collecting supernatant and precipitate respectively, adding purified water into the precipitate to reach crude drug content of 0.3g/ml, spray drying to obtain polysaccharide powder, and recording as material I. Concentrating the supernatant under reduced pressure to obtain extract with water content of 16%, and recording as material II.

(3) Respectively weighing 5% of humectant, 0.095% of preservative, 1% of antioxidant, 20% of material II medicinal extract, 1.5% of material I polysaccharide powder, 0.2% of carbomer-941 and the balance of purified water according to mass percentage. Wherein the humectant is a mixture of 1, 2-propylene glycol and polyethylene glycol-400 in a mass ratio of 5:1; the antioxidant is a mixture of vitamin C and anhydrous sodium sulfite in a mass ratio of 3:1, and the preservative is a mixture of ethyl hydroxybenzoate and propyl hydroxybenzoate in a mass ratio of 1:1.

(4) Placing the polysaccharide powder of the material I into a stirrer, and adding purified water to prepare a polysaccharide water solution with the concentration of 2%; adding carbomer-941 in the step (3) into the polysaccharide water solution, heating to 70 ℃ and continuously standing for 3 hours, adding the humectant, the preservative and the antioxidant weighed in the step (3), keeping the stirring speed at 40r/min, stirring for 10min, adjusting the pH value to 8.5, and marking as a material III for standby.

(5) And (3) adding the material II medicinal material extract obtained in the step (2) into 95% ethanol according to the volume ratio of 4:1, ultrasonically dissolving, and recording as material IV for later use.

(6) Adding the material IV into the material III, stirring at 30r/min for 30min and 40 ℃ to obtain the gel of the traditional Chinese medicine composition for treating acne, and storing in shade.

Example 6

A Chinese medicinal composition film coating agent for treating acne comprises the following effective components extracted by the following method, wherein the preparation is prepared according to the following steps:

weighing 250g of the acne-removing traditional Chinese medicine composition in example 1, crushing into coarse powder by using a crusher, sieving with a No. 1 screen, uniformly mixing, and reflux-extracting with 8 times of 45% ethanol for 3 times, each time for 1h; mixing the ethanol extractive solutions, filtering, recovering ethanol under reduced pressure until no ethanol smell is present, and concentrating into soft extract; weighing 30g of polyvinyl alcohol-124, adding purified water with volume of 10 times, soaking for expansion, heating in water bath to dissolve completely, and stirring; dissolving the soft extract with 500ml water, slowly adding into polyvinyl alcohol solution, and stirring; adding 15ml of glycerol and azone respectively, adding 70% ethanol to 1000ml, stirring thoroughly to make it be in viscose state, packaging, and storing in shade.

Example 7

Weighing 250g of the acne-removing traditional Chinese medicine composition of the example 1, grinding and crushing the acne-removing traditional Chinese medicine composition into superfine powder, uniformly mixing, adding egg white liquid before use, fully stirring the egg white liquid into paste, and externally applying the paste to the face for later use.

Test one: evaluation of bacteriostatic action

Test strain: staphylococcus aureus and propionibacterium acnes

Culture medium and culture conditions: culturing nutrient agar culture medium (36+ -1deg.C) in incubator for 48+ -2 hr for culturing Staphylococcus aureus; the bleb meat culture medium is cultured for 24-72h (36+ -1 ℃) and is used for culturing propionibacterium acnes.

60g of the traditional Chinese medicine compositions of examples 1-4 and comparative examples 1-2 are respectively taken, and dissolved to 1000ml by using propylene glycol with the mass fraction of 20% for detection, and a blank sample is propylene glycol with the mass fraction of 20%.

Table 1. Each of examples, comparative examples, and blank sample paper sheet diffusion method (K-B method) inhibited the diameter of the zone of inhibition of bacteria (n=3, ^* p<0.05 , ^** p<0.01, ^# p<0.05 , ^## p<0.01 vs.blank sample

From the test results, the examples 1-4 and the comparative examples 1-2 can show the effect of inhibiting staphylococcus aureus and propionibacterium acnes, and the antibacterial effect of the formula medicament is better than that of the single medicament of evodia rutaecarpa.

And (2) testing II: irritation test

The acne-removing external preparation prepared in the embodiments 5-7 is sent to a third party detection mechanism to detect skin irritation, and for each preparation, chick embryo continuous skin irritation experiments are used, and the bleeding, coagulation and vascular thawing time of the chick embryo of the test group is higher than 5 hours.

And (3) test III: the human body evaluation of the acne-removing external preparation is carried out according to the 'dermatological medicine clinical research guidelines' to carry out grading judgment:

And (3) healing: skin lesions subside; the effect is shown: the skin damage subsides by more than 60 percent, the swelling and pain of the erythema disappears, and the acne subsides; the method is effective: the skin loss subsides by more than 20-60%, the pain of erythema is relieved, and the acne is partially resolved or disappeared; invalidation: skin lesions regress <20% or aggravate, and swelling and pain of erythema remain, and acne is not improved. Table 2. The results of the self-evaluation by the testers before and after the application of the external preparation for acne treatment of the present invention (n=75)

From the self-evaluation results of the testers, as shown in table 2, the acne-removing external preparation provided by the embodiments 5-7 has good effects of improving skin inflammation and removing acnes on the skin of most testers, and plays roles of inhibiting bacteria, diminishing inflammation and removing acnes.

And (3) testing four: stability test

Test sample: the experimental group is the acne-removing external preparation prepared in examples 5-6 and the powder in example 7; the control group is the acne-removing external preparation prepared in examples 5-6 and the powder in example 7 which are not subjected to temperature test, and the acne-removing external preparation is stored at normal temperature.

1. Heat resistance test

The heat resistance test is to directly put the test samples at room temperature into an oven at 40+/-1 ℃ for 24 hours, and after the test samples are restored to the room temperature, whether the test samples have obvious differences from a control group or not is observed, and the results are shown in Table 3.

2. Cold resistance test

The cold resistance test is to directly put each test sample at room temperature into a low-temperature box at-10 ℃ for 24 hours, and after the test sample is restored to the room temperature, whether the test sample has obvious difference from a control group or not is observed. The results are shown in Table 3.

TABLE 3 stability test results of the external preparation for acne removal of the present invention

The results show that the acne-removing external preparation prepared in the examples 5-6 and the powder prepared in the example 7 have no abnormal condition compared with the corresponding control group after the heat resistance test and the cold resistance test are restored to room temperature, and the traditional Chinese medicine preparation provided by the invention has good stability and can be stored for a long time.

Test five: the safety evaluation of the traditional Chinese medicine preparation

The traditional Chinese medicine preparation has stable vital signs before and after treatment of all subjects, has no obvious abnormal change in liver function, blood convention and blood coagulation function safety index evaluation, has no allergy and serious adverse reaction in patients during the administration period, and is safe and reliable in clinical administration.

Typical cases

Case 1

Aged somewhere, women, 35 years, 8 months 13 days in 2020 with the symptoms: acne on the two cheeks, dark red color, local acne red, dry skin, dry stool and thick tongue fur, and the traditional Chinese medicine composition with the following formula is used for external treatment, and the treatment method comprises the following steps: the gel is applied to the affected part for half an hour every day, the face is cleaned by warm water after application, the affected part is obviously narrowed after 10 days, the skin is moist, and the face is healed after 20 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 10g of ligusticum wallichii, 10g of poria cocos, 20g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of safflower, 10g of peach kernel, 10g of pinellia ternate and 20g of radix ophiopogonis.

Case 2

Yu Mou women, 16 years old, visit in year 6, month 11, 2020, symptoms: acne at forehead, cheek and chin, dark red with facial itching, 3 days of stool, and thick and greasy tongue coating, and adopts the topical treatment of the traditional Chinese medicine composition with the following formula: the gel is applied to the affected part for half an hour every day, and the face is cleaned with warm water after application, and healed after 20 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 10g of ligusticum wallichii, 20g of poria cocos, 20g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of safflower, 10g of peach kernel, 10g of pinellia ternate, 20g of radix ophiopogonis and 10g of cicada slough.

Case 3

Chen Mou women, 50 years old, visit 3 months 20 days 2020, symptoms: the facial speckle is scattered on the color spots, dark brown spots, dark complexion, dry skin, thirst, dry stool and red tongue fur, and the traditional Chinese medicine composition with the following formula is used for external treatment, and the treatment method comprises the following steps of: the gel is applied to the affected part for half an hour every day, the face is cleaned with warm water after application, the color spots are gradually lightened after 6 days, the skin is moist, and the face is healed after 30 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 10g of ligusticum wallichii, 10g of poria cocos, 30g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of safflower, 10g of peach kernel, 10g of pinellia ternate and 30g of radix ophiopogonis.

Case 4

Li Mou men, 20 years, 2021, 7 months 16 visits, symptoms: pustular acne on two sides of cheek and neck, dark red color, bright red local color, dry and hard skin, pain, sticky and greasy stool for 1-2 days, red tongue with yellow and thick coating, and topical treatment with the traditional Chinese medicine composition with the following formula: the external coating agent is applied to the affected part for half an hour every day, the face is cleaned with warm water after application, pain disappears after 3 days, the skin becomes soft, the pustule is reduced, and the face is healed after 20 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 10g of ligusticum wallichii, 10g of poria cocos, 20g of cassia twig, 30g of white paeony root, 20g of rhizoma sparganii, 20g of rhizoma curcumae, 20g of safflower, 10g of peach kernel, 10g of pinellia ternate, 20g of radix ophiopogonis and 20g of dried ginger.

Case 5

Some men, 16 years old, visit in 13 months 4 in 2020, symptoms: the Chinese medicinal composition adopts the following formula for external treatment, and the treatment method comprises the following steps of: the gel is applied to the affected part for half an hour every day, and the face is cleaned with warm water after application, and healed after 18 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 10g of ligusticum wallichii, 10g of poria cocos, 20g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of safflower, 10g of peach kernel, 10g of pinellia ternate and 20g of radix ophiopogonis.

Case 6

Zhao, a woman, 33 years old, 2021, 9 months 1 visit, symptoms: cheek color spots with a small amount of acne marks, dark color, shit and red tongue with thick coating are treated by external application of a traditional Chinese medicine composition with the following formula: egg white is evenly mixed and applied on the face for half an hour every day, warm water is used for cleaning the face after the face is applied, and the face is healed after 15 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 10g of ligusticum wallichii, 10g of poria cocos, 20g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of safflower, 10g of peach kernel, 10g of pinellia ternate and 20g of radix ophiopogonis.

Case 7

Sun Mou women, 60 years, 28 days of diagnosis at 2021, 4 months, symptoms: the senile plaques at the cheek and the temple are obvious, the complexion is dark, the constipation and the pale tongue with cracked coating are caused, and the traditional Chinese medicine composition with the following formula is used for external treatment, and the treatment method comprises the following steps: the external coating agent is applied to the affected part for half an hour every day, the face is cleaned by warm water after application, the color of senile plaque gradually fades after 15 days, the skin color is changed to be moist, and the face is healed after 50 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 20g of ligusticum wallichii, 30g of poria cocos, 20g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of safflower, 10g of peach kernel, 15g of pinellia ternate and 30g of radix ophiopogonis.

Case 8

Some of the plums, women, 35 years old, 8 months of 2021, 2 days of diagnosis, symptoms: white and red comedo at forehead and chin, itching easily after heat and sweating, and thick tongue coating, and the method for treating the acne comprises the following steps: the gel is applied to the affected part for half an hour every day, and the face is cleaned with warm water after application, and healed after 23 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 10g of ligusticum wallichii, 30g of poria cocos, 30g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of safflower, 10g of peach kernel, 10g of pinellia ternate and 20g of radix ophiopogonis.

Case 9

Wang Mou women, 30 years old, 10 days 1 month 2022 visit, symptoms: acne at cheek, red, hard and painful feeling in local contact, hypertrophic scar, dry stool and red tongue with thick coating, and the external treatment method of the traditional Chinese medicine composition adopting the following formula comprises the following steps: the external coating agent is applied to the affected part for half an hour every day, the face is cleaned with warm water after application, pain is relieved after 5 days, the hard spots are softened, and the face is healed after 30 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 20g of ligusticum wallichii, 30g of poria cocos, 30g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of safflower, 10g of peach kernel, 10g of pinellia ternate and 20g of radix ophiopogonis.

Case 10

Zhang Mou women, 19 years old, 3 months of 2022, 2 visits, symptoms: the acne on the face and the chest and back is red, the facial seborrhea is accompanied with thick greasy tongue fur, the traditional Chinese medicine composition with the following formula is adopted for external treatment, and the treatment method comprises the following steps: the gel is applied to the affected part for half an hour every day, and is cleaned with warm water after application, and healed after 25 days.

The formula of the traditional Chinese medicine comprises the following steps:

15g of evodia rutaecarpa, 20g of angelica sinensis, 10g of ligusticum wallichii, 30g of poria cocos, 30g of cassia twig, 30g of white paeony root, 60g of radix puerariae, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 10g of safflower, 10g of peach kernel, 10g of pinellia ternate and 20g of radix ophiopogonis.

Case 11

Some of the holes were treated by men, 23 years old, 4 months of 2022, 13 days, symptoms: the blackhead acne at the forehead is accompanied by a small amount of pimples, red acne rash, itching feeling, sticky and greasy stool and red tongue with yellow coating, and the traditional Chinese medicine composition with the following formula is used for external treatment, and the treatment method comprises the following steps of: the gel is applied to the affected part for half an hour every day, and is cleaned with warm water after application, and healed after 13 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 10g of ligusticum wallichii, 20g of poria cocos, 15g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of safflower, 10g of peach kernel, 10g of pinellia ternate and 20g of radix ophiopogonis.

Case 12

Song Mou men, 28 years old, 2021, visit on 12 months 3 days, symptoms: the acne on the cheek is serious, often has seborrhea, the affected part skin is hard and is accompanied with pain, the stool is in line for 2 to 3 days, the stool is loose, the tongue is red and greasy, and the traditional Chinese medicine composition with the following formula is used for external treatment, and the treatment method comprises the following steps: the external coating agent is applied to the affected part for half an hour every day, the face is cleaned by warm water after application, and the hard junction is softened without pain after 3 days, and the face is healed after 20 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 15g of ligusticum wallichii, 15g of poria cocos, 30g of cassia twig, 30g of white paeony root, 15g of rhizoma sparganii, 15g of rhizoma curcumae, 20g of safflower, 10g of peach kernel, 15g of pinellia ternate and 20g of radix ophiopogonis.

Case 13

Guo Mou men, 24 years, 20 days of 20 years 6, 2021, symptoms: the facial acne, the papule at the mandible is obvious, a small amount of pustules are formed locally, the stool is dry for 2 days, and the tongue is red, the tongue coating is yellow and thick, and the traditional Chinese medicine composition with the following formula is used for external treatment, and the treatment method comprises the following steps of: the gel is applied to the affected part for half an hour a day, the face is washed with warm water after application, the pustule is resolved after 4 days, and the face is healed after 28 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 30g of angelica sinensis, 10g of ligusticum wallichii, 30g of poria cocos, 30g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of safflower, 20g of peach kernel, 10g of pinellia ternate and 20g of radix ophiopogonis.

Case 14

Li Mou women, 16 years old, 8 months 2020, 2 days visit, symptoms: acne on the left side, acne red itching, pale complexion, pale and swollen tongue with tooth marks and thick greasy coating, and adopts the traditional Chinese medicine composition with the following formula for external treatment, and the treatment method comprises the following steps of: the gel is applied to the affected part for half an hour every day, the face is cleaned by warm water after application, the affected part is obviously narrowed after 10 days, and the face is healed after 20 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 20g of ligusticum wallichii, 10g of poria cocos, 20g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of safflower, 10g of peach kernel, 10g of pinellia ternate, 20g of radix ophiopogonis and 20g of dried ginger.

Case 15

Zhao, a woman, 36 years old, 3 months of 2022, 3 days of diagnosis, symptoms: the forehead acne red rash is accompanied with itching feeling, obvious mandibular acne marks, thirst, bitter taste, dry stool and red tongue with yellow fur, and the traditional Chinese medicine composition with the following formula is used for external treatment, and the treatment method comprises the following steps of: the gel is applied to the affected part for half an hour every day, the face is cleaned with warm water after application, the forehead acne eruption is cured after 9 days, and the acne marks are cured after 22 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 10g of ligusticum wallichii, 30g of poria cocos, 20g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 15g of safflower, 10g of peach kernel, 10g of pinellia ternate and 20g of radix ophiopogonis.

Case 16

Wang Mou women, 22 years old, 2021, 12 months 13 days visit, symptoms: the cheek and neck are scattered on the dark red acne, the skin is dry, desquamation, stool, urine yellow, pale tongue and thick coating, the traditional Chinese medicine composition with the following formula is adopted for external treatment, and the treatment method comprises the following steps of: the gel is applied to the affected part for half an hour every day, the face is cleaned by warm water after application, the affected part is obviously narrowed after 10 days, the skin is moist, and the face is healed after 30 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 10g of ligusticum wallichii, 10g of poria cocos, 15g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of safflower, 20g of peach kernel, 10g of pinellia ternate and 30g of radix ophiopogonis.

Case 17

Aged somewhere, women, 56 years, 4 months, 15 days 2021 to visit the doctor, symptoms: the facial dark brown color spots, the dark and matt skin and the red tongue with dry coating are treated by external application of a traditional Chinese medicine composition with the following formula, and the treatment method comprises the following steps of: the egg white is evenly mixed and externally applied to the face for half an hour every day, the face is cleaned by warm water after being applied, the color spots turn light after 20 days, the skin is moist, and the face is healed after 45 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 20g of ligusticum wallichii, 30g of poria cocos, 20g of cassia twig, 50g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of safflower, 20g of peach kernel, 10g of pinellia ternate and 20g of radix ophiopogonis.

Case 18

Sun Mou women, 16 years old, 8 months 2020, 22 days visit, symptoms: the acne on the right face is obvious, the left side is less, the color is dark red, the skin is dry, the stool is dry, the tongue is red and the coating is thick, and the traditional Chinese medicine composition with the following formula is used for external treatment, and the treatment method comprises the following steps: the gel is applied to the affected part for half an hour every day, the face is cleaned by warm water after application, the affected part is obviously narrowed after 12 days, the skin is moist, and the face is healed after 30 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 10g of angelica sinensis, 10g of ligusticum wallichii, 30g of poria cocos, 20g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of safflower, 10g of peach kernel, 10g of pinellia ternate and 20g of radix ophiopogonis.

Case 19

Certain Korean, 40 years old, 8 months 13 days in 2020, with symptoms: the traditional Chinese medicine composition is used for external treatment of facial acne with reddish color, itching feeling, easy oil appearance of skin, red tongue and greasy coating, and the treatment method comprises the following steps: the egg white is evenly mixed and externally applied to the face for half an hour every day, the face is cleaned by warm water after being applied, the affected area is obviously reduced after 6 days, the oil is reduced, and the face is healed after 20 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 10g of ligusticum wallichii, 30g of poria cocos, 20g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of safflower, 10g of peach kernel, 20g of pinellia ternate and 20g of radix ophiopogonis.

Case 20

Liu somebody, woman, 22 years old, 2022, 1 month 6 days visit, symptoms: a small amount of acne with white head on the face, red itching on the face, loose stool, white greasy tongue fur and tooth marks after eating raw and cold food are stimulated, and the traditional Chinese medicine composition with the following formula is used for external treatment, and the treatment method comprises the following steps: the gel is applied to the affected part for half an hour every day, the face is cleaned by warm water after application, the acne subsides after 10 days, the acne does not exist after 23 days, and no itching reaction occurs.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 20g of ligusticum wallichii, 20g of poria cocos, 15g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 10g of safflower, 10g of peach kernel, 10g of pinellia ternate and 20g of radix ophiopogonis.

Case 21

Liu Mou women, 35 years old, 2021, 2 months 16 days visit, symptoms: facial acne is accompanied with red itching, especially on cheekbones, sticky and greasy stool and thick and greasy tongue coating, and is treated by external application of a traditional Chinese medicine composition with the following formula, and the treatment method comprises the following steps of: the gel is applied to the affected part for half an hour every day, and the face is cleaned with warm water after application, so that acne and itching are relieved after 7 days, and the face is healed after 25 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 20g of ligusticum wallichii, 30g of poria cocos, 30g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 10g of safflower, 10g of peach kernel, 10g of pinellia ternate and 20g of radix ophiopogonis.

Case 22

Zhou Mou women, 35 years old, 11 days 1 month 2020, for diagnosis, symptoms: acne and dark spots on forehead and right cheek, dry skin, thirst, clear and long urine, pale tongue and white coating, and the external treatment method of the traditional Chinese medicine composition adopting the following formula: the gel is applied to the affected part for half an hour every day, the face is cleaned by warm water after application, the affected part is obviously narrowed after 10 days, the skin is moist, and the face is healed after 20 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 10g of ligusticum wallichii, 30g of poria cocos, 30g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of safflower, 10g of peach kernel, 10g of pinellia ternate and 10g of radix ophiopogonis.

Case 23

Certain European, female, 15 years, 7 months, 15 days of 2021, with symptoms: the acne around the lips and chin is repeated, the pain is caused when the acne is serious, the skin is easy to get oil, the limbs are cold and loose, and the tongue coating is thin and white, and the traditional Chinese medicine composition with the following formula is used for external treatment, and the treatment method comprises the following steps: the egg white is evenly mixed and externally applied to the face for half an hour every day, the face is cleaned by warm water after being applied, the acne is reduced after 4 days, and the face is healed after 20 days.

The formula of the traditional Chinese medicine comprises the following steps:

15g of evodia rutaecarpa, 20g of angelica sinensis, 30g of ligusticum wallichii, 30g of poria cocos, 30g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of safflower, 10g of peach kernel, 30g of pinellia ternate and 20g of radix ophiopogonis.

Case 24

Publics and women, 60 years old, 22 days of diagnosis at 2021, 3 months, symptoms: the traditional Chinese medicine composition has dark facial spots, dark skin color, dry skin, thirst, pale mouth, less stool for 2-3 days, pale tongue with white coating and cracks, adopts the following formula for external treatment, and adopts the treatment method: the egg white is evenly mixed and externally applied to the face for half an hour every day, the face is cleaned by warm water after being applied, the skin is moist after 15 days, the color spots become shallow, and the face is healed after 50 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 20g of ligusticum wallichii, 10g of poria cocos, 10g of cassia twig, 30g of white paeony root, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of safflower, 20g of peach kernel, 10g of pinellia ternate and 20g of radix ophiopogonis.

Case 25

Meng Mou women, 38 years old, 1 month and 6 days 2022 visit, symptoms: the Chinese medicinal composition for external treatment adopts the following formula: the external gel is applied to the affected parts of the face and back for half an hour every day, and is cleaned with warm water after application, so that acne and comedo are reduced after 5 days, pruritus is eliminated, and the skin is healed after 20 days.

The formula of the traditional Chinese medicine comprises the following steps:

10g of evodia rutaecarpa, 20g of angelica sinensis, 10g of ligusticum wallichii, 10g of poria cocos, 10g of cassia twig, 30g of white paeony root, 15g of rhizoma sparganii, 15g of rhizoma curcumae, 20g of safflower, 10g of peach kernel, 10g of pinellia ternate and 20g of radix ophiopogonis.

The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, but various modifications and variations can be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (3)

1. The application of a traditional Chinese medicine preparation with antibacterial, anti-inflammatory and acne-removing effects in preparing medicines with antibacterial, anti-inflammatory and acne-removing effects is characterized in that the traditional Chinese medicine preparation comprises the following active pharmaceutical ingredients in parts by weight:

1-5 parts of fructus evodiae, 2-10 parts of angelica sinensis, 1-5 parts of ligusticum wallichii, 1-5 parts of poria cocos, 2-10 parts of cassia twig, 3-15 parts of radix paeoniae alba, 1-5 parts of rhizoma sparganii, 1-5 parts of rhizoma curcumae, 2-10 parts of safflower, 1-5 parts of peach kernel, 1-5 parts of pinellia ternate and 2-5 parts of radix ophiopogonis;

the medicine is an external medicine.

2. The use according to claim 1, wherein the pharmaceutically active ingredients comprise the following raw materials in parts by weight:

1 part of evodia rutaecarpa, 2 parts of angelica sinensis, 1 part of ligusticum wallichii, 1 part of poria cocos, 2 parts of cassia twig, 3 parts of white paeony root, 1 part of rhizoma sparganii, 1 part of rhizoma curcumae, 2 parts of safflower, 1 part of peach kernel, 1 part of pinellia ternate and 2 parts of radix ophiopogonis.

3. The use according to claim 1, wherein the Chinese medicinal preparation further comprises pharmaceutically acceptable excipients and/or carriers.