CN108066518A - A kind of dog Chinese medicine bath lotion composition and preparation method thereof - Google Patents

A kind of dog Chinese medicine bath lotion composition and preparation method thereof Download PDF

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Publication number
CN108066518A
CN108066518A CN201810108576.8A CN201810108576A CN108066518A CN 108066518 A CN108066518 A CN 108066518A CN 201810108576 A CN201810108576 A CN 201810108576A CN 108066518 A CN108066518 A CN 108066518A
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parts
chinese medicine
dog
water
lotion composition
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单虎
秦志华
郭沛
张艳萍
张晓莉
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Qingdao Agricultural University
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Qingdao Agricultural University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
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    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234Cnidium (snowparsley)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634Forsythia
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/748Oldenlandia or Hedyotis
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/886Aloeaceae (Aloe family), e.g. aloe vera
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
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    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses a kind of dog Chinese medicine bath lotion composition and preparation method thereof, each component in the herbal raw material including following parts by weight:10 15 parts of kuh-seng, 35 parts of cicada slough, 6 10 parts of almond, 20 30 parts of wormwood, 10 15 parts of frutus cnidii, 58 parts of oldenlandia diffusa, 56 parts of Fructus Forsythiae, 10 15 parts of peppermint, 10 15 parts of aloe, 35 parts of propolis.The present invention selects various traditional Chinese medicinal components, it is small compared to some Western medicine or hormone medicine toxic side effect, desinsection, bactericidal range are wide, and do not easily lead to pathogen, parasite generation drug resistance, and the present invention is treated by way of dipping, it is destroyed without stomach and intestine, but skin is directly acted on, it is fast compared with medicine for oral administration curative effect by drug action in whole body fleshy exterior and affected part, it is without any side effects, burden of liver will not be increased.

Description

A kind of dog Chinese medicine bath lotion composition and preparation method thereof
Technical field
The invention belongs to animal diseases control technical fields, and in particular to a kind of dog Chinese medicine bath lotion composition and its preparation Method.
Background technology
Canine surface hair is longer, often rolls about in the more place of the germs such as ground, thick grass, parasite, hair cleaning It is not diligent etc., easily infect the skin diseases such as dog pyoderma, dermatophytid infection and ectoparasite infestation.
Dog pyoderma is a kind of when with bacterium infection, the skin of skin corium and subcutaneous tissue necrosis formation purulence branch juice Inflammation, and be different from exudative or suppurative surface dermatitis, be divided into impetigo, furuncle and lick preferendum granuloma etc. and is several.Warts Sore is to form the pathological changes such as warts, phlysis in epidermis caused by staphylococcus, streptococcal infection, is more common in the abdomen of dog Portion, it is tiny and white, there is pus to ooze out sometimes and dry formation incrustation, some dogs can be seen around mouth and foot, weak small Dog more susceptible disease, treatment can embrocate the tincture of iodine or the preferable antibacterials of permeability after debridement, and the inflammation of larger area needs complete Body uses antibiotic.Furuncle is a kind of deep hair follicle abscess, generally entails corium or subcutaneous abscess, and then ulceration flows out purulence blood to some, Furuncle is relatively common in the dog for having thick and stiff hair, such as Du Baiwen and Great Dane, in the region that dog body is often pressurized and rubs, such as chest Side, four limbs, the multiple furuncle in position of especially bone protrusion, later stage can form callosity purulence disease because of all Youth League organization's hyperkeratinizations, and Damaged hair follicle then becomes purulence stubble.It is constantly to lick the chronic ulcer of skin stung and caused due to dog to lick preferendum granuloma, how secondary In previous inflammation or itch, Major Clinical variation is:Wound portion is red and swollen, depilation, tissue exudation and inertia epithelial edge, early stage Smaller ulcer surface can locally use corticoid drug.Wearing masks to dog, it is thermophilic constantly to be licked to avoid dog, uses freezing Therapy destroys the granulation tissue of sensitive nerve endings and hyperplasia, with wound healing, increases the activity of dog, can subtract Licking for few dog is thermophilic.
Tinea disease is a kind of common fungal infection skin disease, is mainly in face, trunk, four limbs and afterbody of dog etc., goes out Existing circular or ellipse tinea spot is covered with the scales of skin that peel off of grey above, and the phosphor dot of visible purple is irradiated with ultraviolet radiator.Suffer from The hair color of sick dog can become coarse, and the fur pugil pugil of tinea spot part, which comes off, to fracture or come off, and infected dog can feel It is strange to itch incomparable and go to scratch repeatedly, so disease sites can form alopecia areata.Tinea disease can also be transmitted to the mankind, cause application on human skin scabies Itch, peel.Tinea disease is more common in malnutritive and weak and sickly canine, and the intake for the particularly B family vitamin of having additional nutrients has Beneficial to the recovery for preventing the disease and the animal that caught an illness.The fungi of infection dog has 2 kinds, i.e. microsporum canis and Trichophyton mentagrophytes, and 98% It is microsporum canis, with the differentiation of disease, becomes dry circular macula (coinform tinea) excitatory.At this stage for dog tinea The treatment of disease is mainly the antifungal drugs such as griseofulvin, clotrimazole, still, due to resistance of the spore to heat and disinfection liquid Power is strong, is not easy to be killed, therefore this disease once occurs, and is not easy thoroughly to treat.
Dog acarid is called dog mange, is common canine ectoparasite infestation disease, is commonly called as " mangy dog disease ", be by itch mite or Caused by dog ear itching mite parasitism, 8, September and winter are mainly in, be common in sanitary condition and raises the very poor dog of ventilation condition, mirror Examine the polypide of visible work.Dog acariasis mostly occurs in head, neck, afterbody, and puppy serious symptom first betides the bridge of the nose, cheek, the basal part of the ear And between armpit etc., whole body is then diffused to, originally rubefaction, red lesser tubercle occur, become bubble, bubble ulceration later Afterwards, thick yellow oil exudate is flowed out, fish scale-shaped crust, affected part itching are formed after exudate drying, sick dog is often scratched with pawl It rubs on affected part or other objects, thus serious depilation occurs.If may occur in which pimple after scabies secondary infection, with the state of an illness after Supervention exhibition, diseased region constantly expand, and may spread to whole body.Due to the stimulation that mite excretes poison, characteristics of lesion is to suffer from dog Violent feel of itching occurs, diseased region tubercle, scab are fast, hair loss, and dog is caused only to become thin, is handicapped, is even dead.The disease by More special in the parasitic site of polypide, spread speed is fast, and prevention and treatment just seem more difficult, seriously affect pet Growth, development, production etc., huge harm is caused to pet dog, the aquaculture of cat, simultaneously as itch mite can infect The mankind, pet dog, cat acariasis can bring potentially hazardous and infection to culturist, influence human health.At present, medicine treatment makes With 1% concentration of ivermectin (Ivomec), 0.5-1 mg/kg weight, dorsal sc injection, every the 6-7 months once, 2-3 times It is as a treatment course.Western medicine is used alone at present, effect is simultaneously imprecise, also, sick dog likes skin of dawdling, and skin is caused to damage Wound, secondary bacterial infection, and disease recurrent exerbation, and gargalesthesia can not eliminate.
Summary for the canine skin disease as caused by the reasons such as bacterium, fungi, parasite, uses one more at present A little Western medicine even hormone medicine, effect is imprecise and tends not to effect a radical cure, and be easy to cause canine skin disease and sends out repeatedly Make.Also, a degree of infection is often had resulted in when these skin diseases disease is sent out, has formd larger harm.Mesh Before, canine disease prevention and treatment in it is less for the utilization of Chinese medicine, and the Chinese herbal medicine resource enriched using China develop it is suitable The Chinese medicine preparation of prevention and treatment canine skin disease is closed, the incidence probability of canine skin disease is always controlled, will be canine skin The clinical treatment of skin disease provides new thinking, while also has boundless market prospects.
The content of the invention
It is in view of the deficiencies of the prior art, of the invention by providing a kind of dog Chinese medicine bath lotion composition and preparation method thereof, It can prevent and treat a variety of canine skin diseases, reduce the incidence probability of canine skin disease, and after preventing disease cured Recurrent exerbation.
To achieve the above object, the technical scheme is that a kind of dog Chinese medicine bath lotion composition and preparation method thereof, Each component in herbal raw material including following parts by weight:10-15 parts of kuh-seng, 3-5 parts of cicada slough, 6-10 parts of almond, wormwood 20-30 parts, 10-15 parts of frutus cnidii, 5-8 parts of oldenlandia diffusa, 5-6 parts of Fructus Forsythiae, 10-15 parts of peppermint, 10-15 parts of aloe, bee 3-5 parts of glue.
Preferably, 6-8 parts of artemisia annua is further included.
Preferably, 10-13 parts of garlic garlic clove is further included.
Preferably, 2-3 parts of green salt is further included.
Preferably, 0.5-2 parts of essential oil is further included;The essential oil is lemon grass (Cymbopogon citratus) essential oil, Chinese torreya essential oil, one kind of tea tree ethereal oil It is or a variety of.
The essential oil is lemon grass (Cymbopogon citratus) essential oil, Chinese torreya essential oil, tea tree ethereal oil are according to weight ratio 1:2:1.5 it mixes.
The present invention also provides the dog preparation methods of Chinese medicine bath lotion composition, comprise the following steps:
(1) feedstock processing:By kuh-seng, almond, peppermint, aloe, propolis, artemisia annua, garlic garlic clove and wormwood respectively into Then row drying, grinding and sieving add in abundant mixing after green salt, obtain mixture;
(2) flooding:It heats after mixture obtained by step (1) is added water, is extracted under ultrasonic wave booster action, After extraction, filter to get filtrate I;Filter residue adds water to carry out Ultrasonic Wave-Assisted Extraction, filtering after the same method, repeats 2-3 It is secondary, obtain filtrate II;Merging filtrate I, filtrate II are up to water extract;
(3) ultrasound adverse current is extracted:55-60% ethyl alcohol, ultrasonic wave auxiliary are added in into the extraction filter residue obtained by step (2) The lower adverse current of effect is extracted, and filters to obtain extracting solution I;Filter residue such as adds to carry out ultrasound after the same method at the 55-60% ethyl alcohol of weight The extraction of ripple auxiliary adverse current, filtering, repeat 1-2 times, obtain extracting solution II;Merge extracting solution I, extracting solution II up to adverse current extracting solution;
(4) water boiling and extraction:Cicada slough, frutus cnidii, oldenlandia diffusa and Fructus Forsythiae are taken, the water of 5-8 times of weight is added to impregnate 1- 2h, then intense fire boil, turn after being cooked by slow fire 1.5-2h, decoction liquor I is collected in filtering;The dregs of a decoction add the water intense fire of 2-4 times of weight to boil It opens, turns after being cooked by slow fire 0.5-1h, decoction liquor II is collected in filtering;Merge decoction liquor I, decoction liquor II up to water decoction;
(5) mix, concentrate:It treats that water decoction prepared by step (4) is cooled to less than 50 DEG C, adds in prepared by step (2) Adverse current extracting solution prepared by water extract and step (3) is uniformly mixed, and then low-temperature evaporation is concentrated to give Chinese medicine magma;
(6) sterilization:Chinese medicine magma sterilization prepared by step (5), after adding in essential oil mixing, through sterile dress Bag or it is canned after get product.
Preferably, in step (1), drying temperature is 35-50 DEG C, drying time 12-24h;Smash it through 60 mesh sieves; In step (2), the mixture is 1 according to mass volume ratio with water:The solid-to-liquid ratio mixing of 3-5, is then heated to 40-50 DEG C, Under 700-900W ultrasonic wave booster actions, 20-30min is extracted, after extraction, 1-3 layers of 80-100 mesh filtered through gauze obtains Filtrate I;The filter residue is 1 according to mass volume ratio with water:The solid-to-liquid ratio mixing of 2-3.
Preferably, in step (3), the extraction filter residue is 1 according to mass volume ratio with 55-60% ethyl alcohol:The solid-liquid of 2-3 Than mixing, after countercurrently extracting 50-80min under 1000-1200W ultrasonic wave booster actions, 1-3 layers of 80-100 mesh gauze mistakes Filter to obtain extracting solution I.
Preferably, in step (5), the temperature of low-temperature evaporation is 40-45 DEG C;In step (6), the sterilization mode For one kind in ultraviolet-ray sterilizing or 20KGy60Co sterilizations.
In the present invention, the effect of each raw material, is as follows:
Kuh-seng bitter, it is cold in nature.The thoughts of returning home, liver, stomach, large intestine, bladder warp.For the dry root of legume kuh-seng.With heat-clearing Eliminating dampness, desinsection is antipruritic, local antibacterial antiinflammation, for hot dysentery, has blood in stool.Jaundice renal shutdown, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae are wet Rash, wet sore, pruitus, mange leprosy;Control trichomonas vaginitis outside.
Cicada slough is sweet in flavor, cold in nature.Return lung, Liver Channel.Exuviae shell when sprouting wings for the nymph of the black grasshopper of cicada.With relieve heat Except heat, the effect of relieving sore-throat, promoting eruption moves back screen, spasmolysis.For anemopyretic cold, pharyngalgia, hoarse voice, measles without adequate eruption, rubella itch, hot eyes Buckwheat hinders, convulsion, lockjaw.
(life) almond is bitter, tepor.Amarogentin has antimutagenic effect, can reduce mould by analgin, metronidazole, mitogen The quantity of micronucleus polychromatic erythrocyte caused by plain C etc..Apricot kernel oil also has expelling parasite, bactericidal effect, in vitro test to Ascaris lumbricoides, Earthworm has killing effect, and has antibacterial action to typhoid fever, paratyphosum Bacterium.Almond also has anti-pinworm and trichomonas infection, treatment Alpastic anemia acts on.
Wormwood is bitter in taste, pungent, warm, enters spleen, liver, kidney, there is the benefits of menstruation regulating Zhi Xue ﹑ tocolysis Zhi Beng ﹑ dispelling cold and removing dampnesses.It is modern real Testing research has shown that, folium artemisiae argyi has antibacterial and antivirus action;Hemostasis and blood coagulation resisting function;Calm and anti-allergic effects;Protect liver profit Courage effect etc..Wormwood has a kind of special fragrance, this special fragrance has effects that mosquito dispersing, so, ancients Chang Men Front hanging wormwood, one is used to avoid evil spirits, and two are used to driving mosquito away.Modern pharmacology finds that volatile argyi leaf oil content is more, 1.8- eucalyptus Foline (accounts for more than 50%), other to have α-absinthol, sesquiterpene alcohols and its ester.Air dried leaves contain minerals 10.13%, fat 2.59%, protein 25.85% and vitamin A, B1, B2, C etc..
Frutus cnidii be samphire cnidium monnieri dry mature fruit, it is pungent, bitter, temperature, it is slightly poisonous, have eliminating dampness, wind-dispelling, Desinsection, it is antipruritic, the effect of warming kidney and enhancing body.
Oldenlandia diffusa, it is patent medicine bitter, light, it is cold in nature.Primary efficacy is clearing heat and detoxicating, medicinal powder for relieving pain knot, promoting urination and removing dampness. Outstanding kind treatment various types inflammation, has good therapeutic effect to furuncle sore.In clinical practice, oldenlandia is found If careless compatibility is proper, a variety of diseases can be treated.
Fructus Forsythiae is cool in nature, bitter, nontoxic.Primary efficacy is heat-clearing, removing toxic substances, dissipating bind, detumescence.Control warm, erysipelas, macula, carbuncle Ulcer pyogenic infections, scrofula, urine leaching closes.
Peppermint is pungent cool property sweating antipyretic medicine, controls the diseases such as influenza, headache, hot eyes, body heat, throat, gum swelling and pain. External application can control neuralgia, pruitus, fash and eczema etc..
Aloe is bitter in taste, cold.Primary efficacy is purging intense heat, removing toxic substances, stagnation resolvation, desinsection.Argument is red, constipation, gonorrhoea, hematuria, small Youngster's frightened epilepsy, infantile malnutrition due to digestive disturbances or intestinalparasites, burn and scald, women's amenorrhoea, hemorrhoid, scabies, carbuncle furuncle poison, traumatic injury.Modern pharmacology is found, is had Good bactericidal effect, anti-inflammatory effect moisten beautification function, and the effect of letting out under stomach invigorating, cardiac stimulant promoting blood circulation effect, is immunized and regeneration is made With, immune and antitumor action, detoxication, anti-aging effects, analgesia, sedation, anti-sunlight function.
Its is mild-natured for propolis, and bitter, pungent, micro-sweet have the effect of moisturizing myogenic, anti-inflammatory analgetic, can treat gastric ulcer, oral cavity Ulcer, burn and scald, the symptoms such as skin Tearing Pain, radiation protection.Qi-restoratives for oral administration is weak for it, changes turbid fat, only quenches one's thirst;External application removing toxicity for detumescence.It is interior It takes in physically weak early ageing, hyperlipidemia, quench one's thirst;It controls outside for chapped skin, burn and scald.Propolis includes 20 major classes and more than totally 300 plants Nutritional ingredient.In the ingredient of propolis, most representative active material is Quercetin in flavone compound, terpene and has Phenethyl caffeate in machine acid, except flavonoid beyond the region of objective existence, the also abundant amino acid of propolis, microorganism, fragrant volatile oil, Alkene terpenoid, organic acid, flavanol compound, alcohol, phenol, aldehyde, ketone, ester, ether compound, enzyme and inorganic salts etc., just as One natural " Drug Storage ".
Artemisia annua nature and flavor are worked hard, cool, nontoxic, are trembled with fear.Primary efficacy is heat-clearing solution malaria, and wind dispelling is antipruritic, and leaf juice can apply evil Sore scabies tinea and insect-bite.Artemisia annua is used as medicine, and is used as heat-clearing, relieving summer-heat, preventing malaria, cool blood, also makees externally applied drug, also can be used as fragrance, Animal feeding-stuff.Artemisia annua contains volatile oil, and containing qinghaosu, flavone compound etc..Qinghaosu in artemisia annua is antimalarial Principle active component.
Garlic nature and flavor temperature, it is pungent, sweet.Carbuncle swells black mole sore, exorcising, gas of killing virus can be dissipated.Its primary efficacy is removing toxic substances desinsection, Swelling and pain relieving, antidiarrheal stop dysentery control lung, expelling parasite, in addition, there is warm spleen warm stomach, garlic can control swollen ulcer drug, white bald tinea sore, dysentery Disease diarrhea, tuberculosis pertussis, roundworm pinworm, eating accumulation, coldness and pain in the epigastrium, oedema turgor, gas consumption product, desinsection removing toxic substances.In garlic Sulfur-containing compound (Ailitridin also known as allicin, garlic oil) has strong antibacterial and anti-inflammation functions, to a variety of coccuses, bar Bacterium, fungi and virus etc. have inhibition and killing effect, are one kind that antibacterial action is most strong in the natural plants currently found.
Green salt, nature and flavor:It is salty, cold, there is the effect of cool blood, improving eyesight, for treating haematemesis, bleeding from five sense organs or subcutaneous tissue, hematuria, control hot eyes outside The symptoms such as swelling and pain, toothache.Green salt be also known as " lake salt ", " rock salt ", taste is salty, and chemical composition is sodium chloride, be often mixed with clay and Calcium, magnesium chloride etc. have good bactericidal effect.
Lemon grass (Cymbopogon citratus) essential oil is a kind of essential oil for extracting from lemon grass (Cymbopogon citratus), has extraordinary anti-depression, antibacterial, sterilizes, stomach of dispelling Flatulence, deodorization help digest, diuresis, killing fungus, lactagogue, insecticidal, prevention disease, excitation, mend body and other effects.It can Effective expelling parasite makes flea, pest with animal separate, and deodorization functions can allow animal to keep good odour.
Chinese torreya essential oil will compare the inhibition of fungi that bacterium is good, and research finds the inhibitory action of its bacterium, and there are timeliness Property, 48h or so is present with maximum suppression effect.Also, it is good that zoopery shows that Chinese torreya essential oil has aedes albopictus Repellent effect can be used as culicifuge;And the ethanol extract of Chinese torreya has antiinflammation as rose root extract, card The real saying of the medicinal Chinese torreya anti-inflammatory analgesic of folks of china.
Tea tree ethereal oil is effective against various bacteria, and some researches show that the tea tree ethereal oil of 0.25% concentration can inhibit 90% Escherichia coli, the tea tree ethereal oil of 0.5% concentration are that can inhibit the breeding of staphylococcus aureus or even connect to various The superbacteria that antibiotic has developed immunity to drugs:Anti- methicillinum golden yellow grape wine can be killed.
With prior art ratio, advantageous effects of the invention:
(1) dog Chinese medicine bath lotion composition of the invention, not only simply mixes the Chinese medicine material for having related efficacy, But its medical mechanism is combined, carry out Chinese medicine each component synergistic, so as to play maximum drug effect.The present invention has suppression The effect of bacterium is anti-inflammatory, heat-clearing dissipates poison, it is special compared to the special medicine of Western medicine, it is only capable for the treatment of skin disease in a certain respect, and it is easily multiple Hair, Chinese medicine bath lotion composition prepared by the present invention is medicinal extensively, can effectively treat and be caused by bacterium, fungi and parasite Canine infectious skin disease, therapeutic effect are notable and uneasy to recur.
(2) for the canine of health, by the concentration (increasing extension rate) for reducing Chinese medicine bath lotion composition of the present invention Also good preventive effect can be played.
(3) drug selected by the present invention, there is the effect of moisturizing, clearing heat and detoxicating, dispelling wind and arresting itching, during dipping, water temperature It can open mao key, so as to be applied to epidermis even subepidermal lesions position, open pore can make the effective of drug in addition Ingredient is easier into vivo, and therefore, medicinal effects are more apparent, rapid, can effect a radical cure the various skin infection diseases of canine Disease.Moreover, after canine dipping or shower, position of disease will not feel itch, therefore canine will not be because of excessively itch or pain Pain frequently scratches lesions position, more serious so as to avoid lesions position, alleviates the pain of canine, accelerates and treated Journey.
(4) essential oil in the present invention can not only cover the smell of drug, provide pure and fresh fragrance;And by lemon grass (Cymbopogon citratus) essence Oil, Chinese torreya essential oil, tea tree ethereal oil form composite essential oil according to a certain percentage, and three has synergistic effect, makes the drug of the present invention It is more preferable to prevent and treat effect.
(5) present invention is in preparation process, by, using different processing and extracting mode, making each to different Chinese medicine materials Purpose ingredient in Chinese medicine material sufficiently extracts, and during some dryings, extraction, concentration and disinfection etc., Temperature is controlled, some medicinal ingredients is made to keep the state of active ingredient, so as to ensure that therapeutic effect is notable.
(6) present invention is quick compared to medicine for oral administration, is not easy to apply whole lesions positions with emulsifiable paste compared to dermal application (some site of pathological change naked eyes are invisible) is smeared, can act on all skin focus positions.
Summary, the present invention selects various traditional Chinese medicinal components, small compared to some Western medicine or hormone medicine toxic side effect, Desinsection, bactericidal range are wide, and do not easily lead to pathogen, parasite generation drug resistance, and the present invention is controlled by way of dipping It treats, is destroyed without stomach and intestine, but directly act on skin, by drug action in whole body fleshy exterior and affected part, compared with medicine for oral administration curative effect Soon, it is without any side effects, burden of liver will not be increased.And skin metabolism can also be improved, promoted blood circulation, Virus is killed, eliminates bacterium, enhances disease resistance, makes skin emolliency gloss, high resilience is uneasy to recur after treatment, for strong The canine of health has good preventive effect.
Specific embodiment
Below according to specific embodiment, the present invention is described in further detail.
Embodiment 1
A kind of dog Chinese medicine bath lotion composition and preparation method thereof, including each component in following herbal raw material:Kuh-seng, Cicada slough, almond, wormwood, frutus cnidii, oldenlandia diffusa, Fructus Forsythiae, peppermint, aloe, propolis, artemisia annua further include garlic garlic clove, Green salt, lemon grass (Cymbopogon citratus) essential oil.The specific proportioning of each component is as shown in table 1 in herbal raw material.
A kind of dog preparation method of Chinese medicine bath lotion composition, comprises the following steps:
(1) feedstock processing:By kuh-seng, almond, peppermint, aloe, propolis, artemisia annua, garlic garlic clove and wormwood respectively into Then 35 DEG C of drying 12h of row, grinding and sieving add in abundant mixing after green salt, obtain mixture.
(2) flooding:According to mass volume ratio it is 1 by the mixture obtained by step (1) and water:3 solid-to-liquid ratio mixing, 40 DEG C are then heated to, under 700W ultrasonic wave booster actions, extracts 20min, after extraction, the 80-100 mesh yarns of individual layer Cloth filters to get filtrate I;The filter residue is 1 according to mass volume ratio with water:2 solid-to-liquid ratio mixing, carries out after the same method Ultrasonic Wave-Assisted Extraction, filtering, are repeated 2 times, and obtain filtrate II;Merging filtrate I, filtrate II are up to water extract.
(3) ultrasound adverse current is extracted:According to mass volume ratio it is 1 to the extraction filter residue obtained by step (2) and 55% ethyl alcohol:2 Solid-to-liquid ratio mixing, after countercurrently extracting 50min under 1000W ultrasonic wave booster actions, 80 mesh filtered through gauze of individual layer must be extracted Liquid I;Filter residue such as adds to carry out the extraction of ultrasonic wave auxiliary adverse current, filtering after the same method at 55% ethyl alcohol of weight, is repeated 1 times, Obtain extracting solution II;Merge extracting solution I, extracting solution II up to adverse current extracting solution.
(4) water boiling and extraction:The water that cicada slough, frutus cnidii, oldenlandia diffusa and Fructus Forsythiae add 5 times of weight is taken to impregnate 1h, so Intense fire is boiled afterwards, is turned after being cooked by slow fire 1.5h, and decoction liquor I is collected in filtering;The dregs of a decoction add the water intense fire of 2 times of weight to boil, and turn slow boiling After decocting 0.5h, decoction liquor II is collected in filtering;Merge decoction liquor I, decoction liquor II up to water decoction.
(5) mix, concentrate:It treats that water decoction prepared by step (4) is cooled to less than 50 DEG C, adds in prepared by step (2) Adverse current extracting solution prepared by water extract and step (3) is uniformly mixed, during then low-temperature evaporation is concentrated to give under the conditions of 40 DEG C Medicine magma.
(6) sterilization:By Chinese medicine magma prepared by step (5) using ultraviolet-ray sterilizing, lemon grass (Cymbopogon citratus) essential oil is added in After mixing, through sterile pack or it is canned after up to 300g finished products.
By this method prepare dog with Chinese medicine bath lotion composition when in use, according to liquid:(water temperature is not easy more than 60 water DEG C, inactivated to prevent active ingredient in drug, reduce drug effect) it is 1:(prevention concentration is relatively low i.e. for the volume ratio mixing of 100-3000 Can, treatment concentration is bigger than normal) after, it either takes a shower for pet dog spray-dip after all can impregnating or take a shower, if cleaned with clear water Can, because there is the covering of essential oil smell, flavour of a drug also unobvious, and prevent and treat effect more are cleaned even without clear water Persistently.
Embodiment 2
A kind of dog Chinese medicine bath lotion composition and preparation method thereof, including each component in following herbal raw material:Kuh-seng, Cicada slough, almond, wormwood, frutus cnidii, oldenlandia diffusa, Fructus Forsythiae, peppermint, aloe, propolis, artemisia annua further include garlic garlic clove, Green salt, Chinese torreya essential oil.The specific proportioning of each component is as shown in table 1 in herbal raw material.
A kind of dog preparation method of Chinese medicine bath lotion composition, comprises the following steps:
(1) feedstock processing:By kuh-seng, almond, peppermint, aloe, propolis, artemisia annua, garlic garlic clove and wormwood respectively into For 24 hours, then grinding and sieving adds in abundant mixing after green salt, obtains mixture 50 DEG C of drying of row.
(2) flooding:According to mass volume ratio it is 1 by the mixture obtained by step (1) and water:5 solid-to-liquid ratio mixing, 50 DEG C are then heated to, under 900W ultrasonic wave booster actions, extracts 30min, after extraction, 3 layers of 100 mesh gauze mistakes Filter to obtain filtrate I;The filter residue is 1 according to mass volume ratio with water:3 solid-to-liquid ratio mixing, carries out ultrasound after the same method Ripple Assisted Extraction, filtering, are repeated 3 times, obtain filtrate II;Merging filtrate I, filtrate II are up to water extract.
(3) ultrasound adverse current is extracted:It is according to mass volume ratio with 55-60% ethyl alcohol to the extraction filter residue obtained by step (2) 1:3 solid-to-liquid ratio mixing, after countercurrently extracting 80min under 1200W ultrasonic wave booster actions, 3 layers of 100 mesh filtered through gauze obtain Extracting solution I;Filter residue such as adds to carry out the extraction of ultrasonic wave auxiliary adverse current, filtering after the same method at 60% ethyl alcohol of weight, repeats 2 times, obtain extracting solution II;Merge extracting solution I, extracting solution II up to adverse current extracting solution.
(4) water boiling and extraction:The water that cicada slough, frutus cnidii, oldenlandia diffusa and Fructus Forsythiae add 8 times of weight is taken to impregnate 2h, so Intense fire is boiled afterwards, is turned after being cooked by slow fire 2h, and decoction liquor I is collected in filtering;The dregs of a decoction add the water intense fire of 4 times of weight to boil, and turn to be cooked by slow fire After 1h, decoction liquor II is collected in filtering;Merge decoction liquor I, decoction liquor II up to water decoction.
(5) mix, concentrate:It treats that water decoction prepared by step (4) is cooled to less than 50 DEG C, adds in prepared by step (2) Adverse current extracting solution prepared by water extract and step (3) is uniformly mixed, during then low-temperature evaporation is concentrated to give under the conditions of 45 DEG C Medicine magma.
(6) sterilization:By Chinese medicine magma prepared by step (5) using 20KGy60Co sterilizations, Chinese torreya essence is added in After oil mixing, through sterile pack or it is canned after up to 300g finished products.
By this method prepare dog with Chinese medicine bath lotion composition when in use, according to liquid:(water temperature is not easy more than 60 water DEG C, inactivated to prevent active ingredient in drug, reduce drug effect) it is 1:(prevention concentration is relatively low, controls for the volume ratio of 300-2000 It is bigger than normal to treat concentration) after mixing, after either taking a shower for pet dog spray-dip and all can impregnate or take a shower, if cleaned with clear water Can, because there is the covering of essential oil smell, flavour of a drug also unobvious, and prevent and treat effect more are cleaned even without clear water Persistently.
Embodiment 3
A kind of dog Chinese medicine bath lotion composition and preparation method thereof, including each component in following herbal raw material:Kuh-seng, Cicada slough, almond, wormwood, frutus cnidii, oldenlandia diffusa, Fructus Forsythiae, peppermint, aloe, propolis, artemisia annua further include garlic garlic clove, Green salt, tea tree ethereal oil.The specific proportioning of each component is as shown in table 1 in herbal raw material.
A kind of dog preparation method of Chinese medicine bath lotion composition, comprises the following steps:
(1) feedstock processing:By kuh-seng, almond, peppermint, aloe, propolis, artemisia annua, garlic garlic clove and wormwood respectively into Then 40 DEG C of drying 16h of row, grinding and sieving add in abundant mixing after green salt, obtain mixture.
(2) flooding:According to mass volume ratio it is 1 by the mixture obtained by step (1) and water:4 solid-to-liquid ratio mixing, 45 DEG C are then heated to, under 800W ultrasonic wave booster actions, extracts 25min, after extraction, 2 layers of 80-100 mesh gauzes Filter to get filtrate I;The filter residue is 1 according to mass volume ratio with water:2.5 solid-to-liquid ratio mixing, carries out after the same method Ultrasonic Wave-Assisted Extraction, filtering, are repeated 2 times, and obtain filtrate II;Merging filtrate I, filtrate II are up to water extract.
(3) ultrasound adverse current is extracted:According to mass volume ratio it is 1 to the extraction filter residue obtained by step (2) and 58% ethyl alcohol: 2.5 solid-to-liquid ratio mixing, after countercurrently extracting 60min under 1100W ultrasonic wave booster actions, 2 layers of 90 mesh filtered through gauze obtain Extracting solution I;Filter residue such as adds to carry out the extraction of ultrasonic wave auxiliary adverse current, filtering after the same method at 58% ethyl alcohol of weight, repeats 1 time, obtain extracting solution II;Merge extracting solution I, extracting solution II up to adverse current extracting solution.
(4) water boiling and extraction:The water that cicada slough, frutus cnidii, oldenlandia diffusa and Fructus Forsythiae add 6 times of weight is taken to impregnate 1.5h, Then intense fire is boiled, and is turned after being cooked by slow fire 1.8h, and decoction liquor I is collected in filtering;The dregs of a decoction add the water intense fire of 3 times of weight to boil, and turn text After the pan-fried 0.5h of fire, decoction liquor II is collected in filtering;Merge decoction liquor I, decoction liquor II up to water decoction.
(5) mix, concentrate:It treats that water decoction prepared by step (4) is cooled to less than 50 DEG C, adds in prepared by step (2) Adverse current extracting solution prepared by water extract and step (3) is uniformly mixed, during then low-temperature evaporation is concentrated to give under the conditions of 40 DEG C Medicine magma.
(6) sterilization:By Chinese medicine magma prepared by step (5) using ultraviolet-ray sterilizing, add in tea tree ethereal oil and mix After conjunction, through sterile pack or it is canned after up to 300g finished products.
By this method prepare dog with Chinese medicine bath lotion composition when in use, according to liquid:(water temperature is not easy more than 60 water DEG C, inactivated to prevent active ingredient in drug, reduce drug effect) it is 1:(prevention concentration is relatively low, controls for the volume ratio of 500-1000 It is bigger than normal to treat concentration) after mixing, after either taking a shower for pet dog spray-dip and all can impregnate or take a shower, if cleaned with clear water Can, because there is the covering of essential oil smell, flavour of a drug also unobvious, and prevent and treat effect more are cleaned even without clear water Persistently.
Embodiment 4
A kind of dog Chinese medicine bath lotion composition and preparation method thereof, including each component in following herbal raw material:Kuh-seng, Cicada slough, almond, wormwood, frutus cnidii, oldenlandia diffusa, Fructus Forsythiae, peppermint, aloe, propolis, artemisia annua further include garlic garlic clove, Green salt, lemon grass (Cymbopogon citratus) essential oil, Chinese torreya essential oil, tea tree ethereal oil.The specific of each component is matched somebody with somebody such as shown in table 1 in herbal raw material.
A kind of dog preparation method of Chinese medicine bath lotion composition, comprises the following steps:
(1) feedstock processing:By kuh-seng, almond, peppermint, aloe, propolis, artemisia annua, garlic garlic clove and wormwood respectively into Then 45 DEG C of drying 18h of row, grinding and sieving add in abundant mixing after green salt, obtain mixture.
(2) flooding:According to mass volume ratio it is 1 by the mixture obtained by step (1) and water:4.5 solid-to-liquid ratio mixing, 45 DEG C are then heated to, under 850W ultrasonic wave booster actions, extracts 28min, after extraction, 2 layers of 90 mesh filtered through gauze Obtain filtrate I;The filter residue is 1 according to mass volume ratio with water:3 solid-to-liquid ratio mixing, carries out ultrasonic wave after the same method Assisted Extraction, filtering, are repeated 3 times, and obtain filtrate II;Merging filtrate I, filtrate II are up to water extract.
(3) ultrasound adverse current is extracted:According to mass volume ratio it is 1 to the extraction filter residue obtained by step (2) and 55% ethyl alcohol:2 Solid-to-liquid ratio mixing, after countercurrently extracting 70min under 1000W ultrasonic wave booster actions, 2 layers of 80 mesh filtered through gauze must be extracted Liquid I;Filter residue such as adds to carry out the extraction of ultrasonic wave auxiliary adverse current, filtering after the same method at 60% ethyl alcohol of weight, is repeated 2 times, Obtain extracting solution II;Merge extracting solution I, extracting solution II up to adverse current extracting solution.
(4) water boiling and extraction:Cicada slough, frutus cnidii, oldenlandia diffusa and Fructus Forsythiae are taken, the water of 7 times of weight is added to impregnate 2h, Then intense fire is boiled, and after turning slow boiling 5-2h, decoction liquor I is collected in filtering;The dregs of a decoction add the water intense fire of 4 times of weight to boil, and turn slow boiling After decocting 1h, decoction liquor II is collected in filtering;Merge decoction liquor I, decoction liquor II up to water decoction.
(5) mix, concentrate:It treats that water decoction prepared by step (4) is cooled to less than 50 DEG C, adds in prepared by step (2) Adverse current extracting solution prepared by water extract and step (3) is uniformly mixed, during then low-temperature evaporation is concentrated to give under the conditions of 45 DEG C Medicine magma.
(6) sterilization:Chinese medicine magma prepared by step (5) using ultraviolet-ray sterilizing, add in lemon grass (Cymbopogon citratus) essential oil, After Chinese torreya essential oil, tea tree ethereal oil mixing, through sterile pack or it is canned after up to 300g finished products.
By this method prepare dog with Chinese medicine bath lotion composition when in use, according to liquid:(water temperature is not easy more than 60 water DEG C, inactivated to prevent active ingredient in drug, reduce drug effect) it is 1:(prevention concentration is relatively low, treatment for the volume ratio of 100-500 Concentration is bigger than normal) after mixing, after either taking a shower for pet dog spray-dip and all can impregnate or take a shower, if it is cleaned with clear water, Because there is the covering of essential oil smell, flavour of a drug also unobvious, and it is more lasting to prevent and treat effect are cleaned even without clear water.
The composition and ratio of 1. each embodiment herbal raw material of table
Embodiment 5
1. dog inhibits experiment with the external fungi of Chinese medicine bath lotion composition
It (is diluted to respectively with distilled water different dense with Chinese medicine bath lotion composition with dog prepared by the embodiment of the present invention 1-4 Spend gradient) it is experimental group;Using distilled water as blank control group, (have with commercially available clotrimazole purchased from Shanghai guest's intelligence biotechnology Limit company is diluted to various concentration gradient by the use of distilled water) as positive controls.Carry out external fungi Inhibition test:By Sharpe Culture medium high pressure sterilization under the conditions of 121 DEG C, 20min, after cooling, take each control groups of 1ml, experimental group dilution after drug into Row coating, is inoculated with and is cultivated 3 days after 28-30 DEG C, observed, the results are shown in Table 2.As shown in Table 2, the antimycotic effect of embodiment 4 Fruit is best, it can be seen that, after the mixed essential oil centainly matched adds in, it can not only cover the smell in former Chinese medicine, additionally it is possible to rise Certain bactericidal effect.
The antifungal activity of 2. each embodiment dog Chinese medicine bath lotion composition of table
In table 2, MIC represents minimal inhibitory concentration, and MSC represents minimum bactericidal concentration (original content is 1 before dilution).
2. dog is tested with the external Bacteria suppression of Chinese medicine bath lotion composition
It (is diluted to respectively with distilled water different dense with Chinese medicine bath lotion composition with dog prepared by the embodiment of the present invention 1-4 Spend gradient) it is experimental group;Using distilled water as blank control group, with commercially available penicillin (purchased from raw work bioengineering (Shanghai) Limited company is diluted to various concentration gradient by the use of distilled water) as positive controls.Carry out external Bacteria suppression experiment: By LB culture mediums under the conditions of 121 DEG C, 20min high pressure sterilization, after cooling, take each control groups of 1ml, experimental group dilution after medicine Object is coated, and is inoculated with and is cultivated 24 days after 37 DEG C, is observed, the results are shown in Table 3.As shown in Table 3, the fungi suppression of embodiment 4 Effect processed is best, it can be seen that, after the mixed essential oil centainly matched adds in, it can not only cover the smell in former Chinese medicine, moreover it is possible to Enough play certain bactericidal effect.
The antibacterial activity of 3. each embodiment dog Chinese medicine bath lotion composition of table
In table 3, MIC represents minimal inhibitory concentration, and MSC represents minimum bactericidal concentration (original content is 1 before dilution).
3. dog tests the inhibition of acarid with Chinese medicine bath lotion composition
3.1 experiment packet:It is (dilute with distilled water respectively with Chinese medicine bath lotion composition with dog prepared by the embodiment of the present invention 4 It is interpreted into 100%, 50%, 25%, 10%, 1%, 0.1%, 0.01% concentration) it is experimental group;Using distilled water as blank control Group is positive controls as positive controls to set 2% metronidazole solution.Every group is 10 for examination vermiform mite, each liquid Concentration 3 repeated experiments, results are averaged.
3.2 observation method:500 μ L liquids are drawn with micropipettor to be added dropwise on wave carrier piece, it is with push jack that liquid is uniform It spreads out, the adhesive tape for detecting vermiform mite is affixed on glass slide, ensure that liquid comes into full contact with polypide.Then glass slide is placed in Growth cabinet (30 DEG C of temperature, humidity 75%), micro- Microscopic observation vermiform mite death condition after 12h.
3.3 dead criterions:1min is observed continuously under 400 power microscopes, mite body chelicera or the motionless person of sufficient pawl are preliminary It is judged as death, continues the still motionless person of observation after 30min and be diagnosed as death.
Corrected mortality/%=(blank control group survival borer population-processing group survival mite number)/blank control group survival mite Number × 100
3.4 result
The dog of the embodiment 4 of 4. various concentration of table corrects the death rate with Chinese medicine bath lotion composition
Group Corrected mortality (%) ± SE
100% concentration 100
50% concentration 100
25% concentration 96±6.3
10% concentration 80±9.1
1% concentration 57±5.7
0.1% concentration 39±2.3
0.01% concentration 11±1.8
Blank control group (distilled water) 0
Positive controls (2% metronidazole solution) 62.7±2.5
As shown in Table 4, which has significant killing effect with Chinese medicine bath lotion composition to acarid;Its miticidal effect is with dense Degree increases and increases, and when its concentration reaches 50%, acarid lethality has been 100%;When solution concentration is 25%, mite Worm lethality is 96% or so;When solution concentration is 10%, acarid lethality is 80% or so;When solution concentration is 1% When, acarid lethality is 57% or so;When solution concentration is 0.1%, acarid lethality is 39% or so.Experiment proves:It should Dog has vermiform mite with Chinese medicine bath lotion composition killing effect and effect is extremely notable.
4. mouse skin stimulation test
Animal packet and experiment pre-treatment:Healthy white rabbit 20 is taken, weight 25-30g, male and female is fifty-fifty, is raised before testing It supports 1 week, and observes diet and behavior, if being normally randomly divided into 5 groups, every group 4 according to star note, weight.It for 24 hours will be every before administration Group mouse back backbone both sides hair subtracts, and is 1cm per side hair removal section area2.Medication:During the dog of embodiment 4 is used Dip composition respectively with clear water dilution 0 times (stoste), 10 times, 100 times, 1000 times, 10000 times, be applied to respectively every group small The left side hair removal section of mouse is smeared 5 times, each dosage 1ml;The right side hair removal section of mouse is coated with the clear water of equivalent;It, will after administration Both sides hair removal section cover gauze (under) and preservative film (on), blend compounds cloth is fixed, keep drug with being removed after skin contact 6h Then gauze and preservative film wash away left drug with warm water (right side hair removal section is equally cleaned with warm water);It is administered once daily, even Continuous 7d.Removal drug 2h and again observation skin condition before administration every time.1,12,24,48 again after last dose and removal drug Secondary observe and record smears position whether there is erythema and oedema and recovery situation, and evaluation criterion is shown in Table 5, table 6.
5. skin wound repair symptom standard of table
6. skin irritatin intensity evaluation of table
Score value Evaluation
0-0.5 It is nonirritant
0.5-2 Slight stimulation
2-6 Poisoning irritation
6-8 Intensity stimulates
It by experimental administration and visually observes, the Skin-test whole process of right side hair removal section is without apparent erythema, oedema Wait skin wound repairs symptom;In the hair removal section of left side, the dog of embodiment 4 is with Chinese medicine bath lotion composition stoste and dilutes 10 The dilution of (i.e. 10% concentration) 1h after drug 1h and after the last administration last dose and removal drug is removed has slightly again Erythema and oedema, reluctantly as it can be seen that after still removing drug 6h and after the last administration after last dose and removal drug after 12h Erythema and oedema are vanished from sight;Dilute the dilution of 100 times (i.e. 1% concentration) and Yi Shang multiple in the hair removal section of left side into Row smear, daily remove drug after 1h, again administration before and after the last administration last dose and removal drug after 1,12,24, For 48h without the skin wound repairs symptom such as apparent erythema, oedema, every score value is zero.It can be seen that the dog of the present invention is used Chinese medicine bath lotion composition stoste dilutes 100 times and above multiple (i.e. concentration is less than 1%), is taken a shower to pet dog or spray-dip It is safe.
5. canine therapeutic effect
Canine infectious skin disease, diseased dog face, neck are caused by bacterium, fungi and parasite in the treatment of certain pet clinic Different degrees of depilation occurs at infection for portion, back, skin of abdomen flush, itching.There is warts in affected part, and pachyderma is removed Skin wet and in cerise after crust.Sick dog have sharp ears and root of the tail etc. are coated a large amount of crusts and the scales of skin that peel off, Head And Face and body surface its Break hair at its position, and circular hair removal section scurf is more.
100 times of the drug dilution (i.e. 1% concentration of stoste) provided using 1-4 of the embodiment of the present invention sick dog as experiment Group;Blank control group is uncomfortable to be cured with medicine, is only impregnated with clear water.Concrete operations are:Impregnating 30min to canine, (water temperature controls 35-40 DEG C), it impregnated once, is used in conjunction 10 days, significant effect, criterion is shown in Table 7, and concrete condition is shown in Table 8 every 2 days.
7. canine skin disease of table cures criterion
8. different pharmaceutical of table is to different canine treating for skin disease effects
From table 7 and table 8, using the dog Chinese medicine bath lotion composition of 1% concentration of the embodiment of the present invention 1-4, control More rate more than 80%, total effective rate more than 90%, it is therefore seen that, dog of the invention is with Chinese medicine bath lotion composition for controlling It treats and causes canine infectious skin disease that there is good effect by bacterium, fungi and parasite.
Although above having used general explanation and specific embodiment, the present invention is described in detail, at this On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore, These modifications or improvements without departing from theon the basis of the spirit of the present invention belong to the scope of protection of present invention.

Claims (10)

1. a kind of dog Chinese medicine bath lotion composition and preparation method thereof, it is characterised in that:Chinese herbal medicine including following parts by weight is former Each component in material:10-15 parts of kuh-seng, 3-5 parts of cicada slough, 6-10 parts of almond, 20-30 parts of wormwood, 10-15 parts of frutus cnidii, white flower 5-8 parts of HERBA HEDYOTIS DIFFUSAE, 5-6 parts of Fructus Forsythiae, 10-15 parts of peppermint, 10-15 parts of aloe, 3-5 parts of propolis.
2. dog according to claim 1 Chinese medicine bath lotion composition, it is characterised in that:Further include 6-8 parts of artemisia annua.
3. dog according to claim 2 Chinese medicine bath lotion composition, it is characterised in that:Further include 10-13 parts of garlic garlic clove.
4. dog according to claim 3 Chinese medicine bath lotion composition, it is characterised in that:Further include 2-3 parts of green salt.
5. dog according to claim 4 Chinese medicine bath lotion composition, it is characterised in that:Further include 0.5-2 parts of essential oil;It is described Essential oil is lemon grass (Cymbopogon citratus) essential oil, Chinese torreya essential oil, the one or more of tea tree ethereal oil.
6. dog according to claim 5 Chinese medicine bath lotion composition, it is characterised in that:The essential oil for lemon grass (Cymbopogon citratus) essential oil, Chinese torreya essential oil, tea tree ethereal oil are according to weight ratio 1:2:1.5 it mixes.
7. according to the preparation method of claim 4-6 any one of them dog Chinese medicine bath lotion composition, which is characterized in that including Following steps:
(1) feedstock processing:Kuh-seng, almond, peppermint, aloe, propolis, artemisia annua, garlic garlic clove and wormwood are dried respectively Dry, then grinding and sieving adds in abundant mixing after green salt, obtains mixture;
(2) flooding:It heats after mixture obtained by step (1) is added water, is extracted under ultrasonic wave booster action, extraction knot Shu Hou, filter to get filtrate I;Filter residue adds water to carry out Ultrasonic Wave-Assisted Extraction, filtering after the same method, repeats 2-3 times, must filter Liquid II;Merging filtrate I, filtrate II are up to water extract;
(3) ultrasound adverse current is extracted:55-60% ethyl alcohol is added in into the extraction filter residue obtained by step (2), under ultrasonic wave booster action Adverse current is extracted, and filters to obtain extracting solution I;Filter residue such as adds to carry out ultrasonic wave auxiliary after the same method at the 55-60% ethyl alcohol of weight Adverse current extraction, filtering, repeat 1-2 times, obtain extracting solution II;Merge extracting solution I, extracting solution II up to adverse current extracting solution;
(4) water boiling and extraction:Cicada slough, frutus cnidii, oldenlandia diffusa and Fructus Forsythiae are taken, the water of 5-8 times of weight is added to impregnate 1-2h, so Intense fire is boiled afterwards, is turned after being cooked by slow fire 1.5-2h, and decoction liquor I is collected in filtering;The dregs of a decoction add the water intense fire of 2-4 times of weight to boil, and turn text After the pan-fried 0.5-1h of fire, decoction liquor II is collected in filtering;Merge decoction liquor I, decoction liquor II up to water decoction;
(5) mix, concentrate:It treats that water decoction prepared by step (4) is cooled to less than 50 DEG C, adds in water logging prepared by step (2) Adverse current extracting solution prepared by extract and step (3) is uniformly mixed, and then low-temperature evaporation is concentrated to give Chinese medicine magma;
(6) sterilization:Chinese medicine magma sterilization prepared by step (5), after adding in essential oil mixing, through sterile pack or tank It is got product after dress.
8. the dog according to claim 7 preparation method of Chinese medicine bath lotion composition, it is characterised in that:In step (1), dry Dry temperature is 35-50 DEG C, drying time 12-24h;Smash it through 60 mesh sieves;In step (2), the mixture and water according to Mass volume ratio is 1:The solid-to-liquid ratio mixing of 3-5, is then heated to 40-50 DEG C, under 700-900W ultrasonic wave booster actions, leaching 20-30min is carried, after extraction, 1-3 layers of 80-100 mesh filtered through gauze obtains filtrate I;The filter residue is with water according to quality volume Than for 1:The solid-to-liquid ratio mixing of 2-3.
9. the dog according to claim 7 preparation method of Chinese medicine bath lotion composition, it is characterised in that:In step (3), institute It is 1 according to mass volume ratio that extraction filter residue, which is stated, with 55-60% ethyl alcohol:The solid-to-liquid ratio mixing of 2-3, it is auxiliary in 1000-1200W ultrasonic waves After helping the lower adverse current extraction 50-80min of effect, 1-3 layers of 80-100 mesh filtered through gauze obtains extracting solution I.
10. the dog according to claim 7 preparation method of Chinese medicine bath lotion composition, it is characterised in that:In step (5), The temperature of low-temperature evaporation is 40-45 DEG C;In step (6), the sterilization mode is ultraviolet-ray sterilizing or 20KGy60Co One kind in sterilization.
CN201810108576.8A 2018-02-02 2018-02-02 A kind of dog Chinese medicine bath lotion composition and preparation method thereof Pending CN108066518A (en)

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