CN102100864A - Chinese medicinal spray for preventing canine skin diseases caused by inflection of pathogenic microorganisms and preparation method thereof - Google Patents

Abstract

The invention relates to a Chinese medicinal spray for preventing canine skin diseases caused by the inflection of pathogenic microorganisms and a preparation method thereof. The Chinese medicinal spray is prepared from the following raw materials in part by weight: 17 to 23 parts of sessile stemona root, 17 to 23 parts of lightyellow sophora root, 37 to 43 parts of densefruit pittany root-bark, 12 to 18 parts of common cnidium fruit, 12 to 18 parts of belvedere fruit and 7 to 13 parts of hibiscus syriacus bark. The preparation method comprises the following steps of: extracting the sessile stemona root, the lightyellow sophora root and the hibiscus syriacus bark by using ethanol twice, recovering the ethanol until the mixture does not have ethanol taste, mixing dregs and the densefruit pittany root-bark, the common cnidium fruit and the belvedere fruit, extracting the mixture in water twice, filtering, mixing two kinds of extract, and concentrating to form the spray. The Chinese medicinal spray can fulfill the aims of preventing the canine skin diseases by clearing heat and detoxicating, eliminating dampness and killing insects and dispelling wind and arresting itching. The Chinese medicinal spray is formed by extracting and refining traditional Chinese medicines, does not have any toxic or side effect on dogs, is convenient to use and easy to operate, is prepared by a stable and feasible process, is suitable for industrial production, can prevent the canine skin diseases caused by the inflection of the pathogenic microorganisms effectively and has excellent developing significance and market prospects.

Description

A kind of prevention dog is because the pathogenic infection microorganism causes dermopathic Chinese medicine spray and preparation method thereof

Technical field

The present invention relates to a kind of prevention dog because the pathogenic infection microorganism causes dermopathic Chinese medicine spray and preparation method thereof, is the injection of feedstock production with the Chinese herbal medicine particularly, belongs to technical field of Chinese medicines.

Background technology

The dog dermatosis is the disease general designation that can cause that dog skin pruritus, depilation, incrustation and skin abnormality change.Be that the clinical onset rate is higher, pathological process is long, type and symptom are differentiated the big disease of difficulty, its paathogenic factor is comparatively complicated, and of a great variety, the dermatosis type according to the clear and definite dog of practical situation is the basis of diagnosis and treatment clinically.Dermopathic classification has several diverse ways, be broadly divided into 16 classes by its pathogenic factor, it comprises: malis, bacterial dermatosis, dermatomycosis, allergic skin disease, hormonal dermatosis, metabolic dermatosis, viral dermatosis, autoimmune dermatosis, seborrheic dermatitis, the dermatosis relevant with physical factor, the dermatosis relevant with chemical factor, toxicodermatitis, dermatosis, cutaneous tumor, eosinophilic granuloma and other dermatosis etc. relevant with inherited genetic factors.Wherein because cause pathogeny imcrobe infection causes dermatosis quite serious to the harm of dog.Developed successively both at home and abroad at present and much be used to prevent the dermopathic medicine of dog, but existed the resisting pathogenic microbes spectrum narrow, many shortcomings such as the not good and toxic and side effects of preventive effect is bigger can not satisfy actual demand.

Summary of the invention

The object of the present invention is to provide and a kind ofly prevent dog because dermopathic Chinese medicine spray of causing of pathogenic infection microorganism and preparation method thereof, but this medicine heat-clearing and toxic substances removing, removing dampness and killing parasites, dispelling wind for relieving itching reach the prevention dog because the dermopathic purpose that the pathogenic infection microorganism causes.

The present invention prevents dog because the dermopathic Chinese medicine spray that the pathogenic infection microorganism causes is made by following parts of medicines by weight:

Radix Stemonae 17-23 part, Radix Sophorae Flavescentis 17-23 part, Cortex Dictamni 37-43 part, Fructus Cnidii 12-18 part, Fructus Kochiae 12-18 part, Cortex Hibisci 7-13 part.

The dermopathic medicine that above-mentioned prevention dog causes owing to the pathogenic infection microorganism, preferred proportion is as follows:

20 parts of the Radixs Stemonae, 20 parts of Radix Sophorae Flavescentiss, 40 parts of Cortex Dictamnis, 15 parts of Fructus Cnidiis, 15 parts of the Fructus Kochiae, 10 parts of Cortex Hibiscis.

The preparation method of medicine of the present invention may further comprise the steps:

With the Radix Stemonae, Radix Sophorae Flavescentis, Cortex Hibisci adds 6-10 alcohol reflux doubly 1-3 time, each 1-3h, merge extractive liquid,, recovery ethanol gets Radix Sophorae Flavescentis to there not being the alcohol flavor, the Radix Stemonae, the Cortex Hibisci extracting solution is with the Radix Stemonae behind the ethanol extraction, Radix Sophorae Flavescentis, Cortex Hibisci medicinal residues and Cortex Dictamni, Fructus Cnidii, the Fructus Kochiae mixes, adding 6-10 times of decocting boils 2-3 time, each 0.5-1h is concentrated into the medicinal liquid that relative density is 1.02-1.1, with the Radix Stemonae, Radix Sophorae Flavescentis, the Cortex Hibisci extracting solution mixes, filter, concentrate, adding distil water is an amount of, makes the medicinal liquid that every 1ml contains crude drug in whole 1g, filter, fill, sterilization is the prevention dog because the dermopathic Chinese medicine spray that the pathogenic infection microorganism causes.

Each medicinal property is as follows:

The Radix Stemonae: the dried root of Stemonaceae plant Radix Stemonae Stemona sessilifolia (Miq.) Miq., Radix stemonae japonicae Stemona japonica (Bl.) Miq. or radix stemonae tuberosae Stemona tuberosa Lour..Sweet, bitter, tepor.Return lung meridian.Slightly poisonous.Nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Be used for new chronic cough and cough, pulmonary tuberculosis cough, pertussis; Be used for head louse outward, body louse, enterobiasis, pudendal pruritus.Honey Radix Stemonae nourishing the lung to arrest cough.Be used for deficiency of YIN chronic cough.Studies show that, (kind is not identified) decoct of Radix Stemonae during in vitro tests and the immersion of radix stemonae tuberosae ethanol are to various pathogens such as streptococcus pneumoniae, beta hemolysis type streptococcus, meningococcus, staphylococcus aureus, Staphylococcus albus and dysentery bacterium, Bacillus typhi, Salmonella paratyphi, escherichia coli, Bacillus proteus, diphtheria corynebacterium, pneumobacillus, bacillus pestis, anthrax bacillus, bacillus subtilis, and vibrio cholera, Bacillus tuberculosis etc. all have bacteriostasis in various degree.The Radix stemonae japonicae infusion has certain inhibitory action external to some pathomycete; But also there is report that fungus be there is no antibacterial action.The Radix Stemonae (kind not clear) can prolong life-span to 36 hour of the Embryo Gallus domesticus of cultivation Newcastle virus.The infusion of Radix stemonae japonicae and other kinds Radix Stemonae (kind is not identified) and ethanol immersion all have killing action to mosquitos and flies larva, head louse, clothing louse and Cimex bedbug etc.The high concentration Radix Stemonae (kind not clear) is external and can kill the Mus pinworm.

Radix Sophorae Flavescentis: the dry root of leguminous plant Radix Sophorae Flavescentis Sophora flavescens Ait..Hardship, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel.Heat clearing and damp drying, parasite killing, diuresis.Be used for hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.

Cortex Dictamni: the root bark of the dittany Dictammnus dasycar pusTurcz that the Rutaceae perennial herb is planted.Bitter cold is gone into spleen, the stomach warp.Heat-clearing and toxic substances removing, expelling wind and removing dampness.Be used for diseases such as damp and hot sore, rubella, scabies, skin scratch, arthralgia chiefly caused by damp pathogen, jaundice.

Fructus Cnidii: the dry mature fruit of samphire cnidium monnieri Cnidium monnieri (L.) Cuss..Hot, bitter, temperature; Slightly poisonous.Return kidney channel.Warming the kidney to invigorate YANG, dampness is dispeled the wind, parasite killing.Be used for sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; The external treatment vulval eczema, married woman's pudendal pruritus; Trichomonal vaginitis." the SHENGCAO property of medicine is wanted fully ": " it is antipruritic to apply skin ulcer, washes the Ci leprosy." studies show that osthole, bergapton and isopimpinellin in vitro tests have strong activity to the Trichophyton mentagrophytes of Trichophyton; Xanthotoxol has apparent antifungal effect.

The Fructus Kochiae: the dry mature fruit of chenopod Fructus Kochiae Kochia scoparia (L.) Schrad..Hot, bitter, cold.Return kidney, urinary bladder channel.Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.Be used for difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus." not Lu ": " steam in the peeling skin, the malignant boil that looses, the hernia abdominal mass, reinforcing YIN-essence makes the people moist.Long-pending heat in " " book on Chinese herbal medicine is original ": " peeling skin is removed the skin exogenous damp and is itched." result of study shows that Fructus Kochiae water logging agent (1: 3) is in vitro to oidium schoenleinii, and dermatophytess such as the Ang Shi microspore of society tinea bacterium difficult to understand have inhibitory action.The infusion tube dilution method, being permitted blue achorion, microsporon audouini and star-shaped nocardia etc. for 1: 3 pair all has inhibitory action.Bacteriostasis water logging agent (1: 3) in test tube to oidium schoenleinii, Du Ang Shi budlet spore tinea bacterium difficult to understand, rust budlet spore tinea bacterium, dermatophytess such as Pilus Caprae seu Ovis sample budlet spore tinea bacterium all have the different bacteriostasis of degree.50% decoct dry plate trench method has more weak inhibitory action to Bacillus typhi.In addition, Fructus Kochiae water extract has inhibitory action to mouse monokaryon macrophage system and delayed hypersensitivity.

Cortex Hibisci: peel of stem or the root bark of Malvaceae Hibiscus plant Hibiscus syriacus L. Hibiscus syriacus L..Sweet, tepor.Clearing away heat-damp and promoting diuresis, killing parasites for relieving itching.Be used for dysentery, leucorrhea; Eczema scrotum tinea corporis, tinea pedis are controlled in external." detailed outline ": " control leucorrhea with red and white discharge, the scabies that swells and ache is washed order and is made brightly, moisturizes and invigorates blood circulation." tube dilution method is used in the ethanol immersion of stem and root after boiling off ethanol, 1: the 100 pair of staphylococcus aureus, bacillus subtilis, and 1: 20 pair of dysentery bacterium, Bacillus proteus all have inhibitory action.

The specific embodiment:

With the Radix Stemonae, Radix Sophorae Flavescentis adds 8 times 75% alcohol reflux 2 times, each 1h, merge extracted twice liquid, recovery ethanol gets Radix Sophorae Flavescentis to there not being the alcohol flavor, the Radix Stemonae, the Cortex Hibisci extracting solution is with the Radix Stemonae behind the ethanol extraction, Radix Sophorae Flavescentis, Cortex Hibisci medicinal residues and Cortex Dictamni, Fructus Cnidii, the Fructus Kochiae mixes, adding 8 times of decoctings boils 2 times, each 1h is concentrated into relative density and is 1.025 medicinal liquid, with the Radix Stemonae, Radix Sophorae Flavescentis, the Cortex Hibisci extracting solution mixes, filter, concentrate, adding distil water is an amount of, to 120ml, filter, fill, sterilization is the prevention dog because the pathogenic infection microorganism causes dermopathic Chinese medicine spray.

Usage and dosage: the dog whole body is rinsed well, dried, press the warm water mixing of the using dosage of 3-6ml/kg body weight with medicine of the present invention and twice dose, the whole body spraying is not sprayed onto ophthalmic, 1 time weekly.

Claims (4)

1. a prevention dog is made by following parts of medicines by weight because the pathogenic infection microorganism causes dermopathic medicine:

Radix Stemonae 17-23 part, Radix Sophorae Flavescentis 17-23 part, Cortex Dictamni 37-43 part, Fructus Cnidii 12-18 part, Fructus Kochiae 12-18 part and Cortex Hibisci 7-13 part.

2. require described prevention dog because the dermopathic medicine that the pathogenic infection microorganism causes is made by following parts of medicines by weight: 20 parts of the Radixs Stemonae, 20 parts of Radix Sophorae Flavescentiss, 40 parts of Cortex Dictamnis, 15 parts of Fructus Cnidiis, 15 parts of the Fructus Kochiae, 10 parts of Cortex Hibiscis according to right 1.

3. the preparation method of right 1 or 2 described medicines, it is characterized in that: with the Radix Stemonae, Radix Sophorae Flavescentis, Cortex Hibisci adds 6-10 alcohol reflux doubly 1-3 time, each 1-3h, merge extractive liquid,, reclaim ethanol to there not being the alcohol flavor, get Radix Sophorae Flavescentis, the Radix Stemonae, the Cortex Hibisci extracting solution, with the Radix Stemonae behind the ethanol extraction, Radix Sophorae Flavescentis, Cortex Hibisci medicinal residues and Cortex Dictamni, Fructus Cnidii, the Fructus Kochiae mixes, and adds 6-10 times of decocting and boils 2-3 time, each 0.5-1h, be concentrated into the medicinal liquid that relative density is 1.02-1.1, with the Radix Stemonae, Radix Sophorae Flavescentis, the Cortex Hibisci extracting solution mixes, and filters, and concentrates, adding distil water is an amount of, make the medicinal liquid that every 1ml contains crude drug in whole 1g, filter fill, sterilization is the prevention dog because the dermopathic Chinese medicine spray that the pathogenic infection microorganism causes.

4. the preparation method of right 1 or 2 described medicines, it is characterized in that: with the Radix Stemonae, Radix Sophorae Flavescentis, Cortex Hibisci adds 8 times 75% alcohol reflux 2 times, each 1h merges extracted twice liquid, reclaims ethanol to there not being the alcohol flavor, get Radix Sophorae Flavescentis, the Radix Stemonae, the Cortex Hibisci extracting solution, with the Radix Stemonae behind the ethanol extraction, Radix Sophorae Flavescentis, Cortex Hibisci medicinal residues and Cortex Dictamni, Fructus Cnidii, the Fructus Kochiae mixes, and adds 8 times of decoctings and boils 2 times, each 1h, be concentrated into relative density and be 1.025 medicinal liquid, with the Radix Stemonae, Radix Sophorae Flavescentis, the Cortex Hibisci extracting solution mixes, and filters, and concentrates, adding distil water is an amount of, to 120ml, filter fill, sterilization is the prevention dog because the dermopathic Chinese medicine spray that the pathogenic infection microorganism causes.