CN101612343B - Lotion for treating female vagina inflammation - Google Patents
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Abstract
The invention relates to lotion for treating female vagina inflammation, aiming at providing lotion which has obvious clinical curative effect for treating gynecologic inflammation, has small side effect to the body and does not destroy the self defense function of the human body. The invention has the technical scheme that the lotion is external-application lotion prepared from the following raw materials according to parts by weight: 10 to 20 parts of coptis root, 10 to 20 parts of yellow-corktree bark, 10 to 20 parts of baikal skullcap root, 20 to 40 parts of cnidium fruit, 20 to 40 parts of broom cypress fruit, 5 to 15 parts of dried alum, 20 to 40 parts of cordate houttuynia, 20 to 40 parts of kuhseng, 20 to 40 parts of wild chrysanthemum flower, 20 to 40 parts of radix gentianae, 20 to 40 parts of smilax glabra rhizoma, 10 to 20 parts of stemona root, 20 to 40 parts of zanthoxylum, 20 to 40 parts of dandelion, 15 to 25 parts of radix sileris, 20 to 40 parts of borax, 10 to 20 parts of peppermint, 20 to 40 parts of angelica, 20 to 40 parts of radix arnebiae seu lithospermi and 10 to 20 parts of licorice. The invention is suitable for clinically common gynecologic inflammation.
Description
Technical field
The present invention relates to a kind of washing liquid for the treatment of female vagina inflammation.Be applicable to clinical common gynecologic inflammation, as vaginitis, cervicitis, pelvic inflammatory disease and endometritis etc.
Background technology
Gynecological inflammation is the commonly encountered diseases and the frequently-occurring disease of between twenty and fifty and old women, and clinical common gynecologic inflammation has vaginitis, cervicitis, pelvic inflammatory disease and endometritis etc.Gynecological inflammation pathogenic factor complexity is various, and is closely related with physical weakness or unclean life style etc.According to World Health Organization's statistics, about 87% adult female in the whole world suffers from gynecological inflammation in various degree, and China women at 41% reproduction age suffers from gynecological inflammation in various degree, and the married woman is more up to 70%.In recent years along with the sexuality factor of dying increases, the gynecological inflammation sickness rate is obvious ascendant trend.Because the structural cause specific of female pathology, female sex organ very easily infects pathogen such as staphylococcus aureus, Candida albicans, novel candidiasis, Pseudomonas aeruginosa, group B streptococcus, bacillus pyocyaneus, escherichia coli, yeast and infusorian.Therefore, gynecological inflammation particularly chronic cervicitis, chronic pelvic inflammatory disease has long, the easy characteristics such as recurrence of the course of disease, not only brings great health to endanger to the women, but also usually causes infertile, ectopic pregnancy and pelvic pain etc., have a strong impact on WomanHealth, increase family and social economy's burden.
Gynecological inflammation treatment at present is mainly based on medicine for external use, as lotion, suppository, effervescent, foam, gel etc., most drug contains metronidazole, clotrimazole class antibiotic or sanitizer chemical, long-term this class medicine that too much uses not only causes damage to organs such as liver, kidneys, and make pathogenic bacteria produce drug resistance easily, destroy the mutual restriction relation between the vagina normal flora and cause dysbacteriosis, thereby cause the destruction of the self-cleaning and defence capability of vagina, cause the growth of pathogen such as fungus vigorous, treat not thoroughly, the state of an illness has repeatedly.Along with clinical disease course and treatment cycle constantly prolong, drug dose constantly increases, and disease also can not get effectively treatment and control.
Summary of the invention
The technical problem to be solved in the present invention is: providing a kind of has remarkable clinical efficacy to the treatment gynecological inflammation, yet little to the side effect of health, is difficult for producing drug resistance, can not destroy the washing liquid of the treatment female vagina inflammation of human body self defense function.
The technical solution adopted in the present invention is: the washing liquid of treatment female vagina inflammation is the external wash liquid that is become by following weight portion feedstock production: Rhizoma Coptidis 10-20 part, Cortex Phellodendri 10-20 part, Radix Scutellariae 10-20 part, Fructus Cnidii 20-40 part, Fructus Kochiae 20-40 part, dried Alumen 5-15 part, Herba Houttuyniae 20-40 part, Radix Sophorae Flavescentis 20-40 part, Flos Chrysanthemi Indici 20-40 part, Radix Gentianae 20-40 part, Rhizoma Smilacis Glabrae 20-40 part, Radix Stemonae 10-20 part, Fructus Zanthoxyli 20-40 part, Herba Taraxaci 20-40 part, Radix Saposhnikoviae 15-25 part, Borax 20-40 part, Herba Menthae 10-20 part, Radix Angelicae Sinensis 20-40 part, Radix Arnebiae (Radix Lithospermi) 20-40 part, Radix Glycyrrhizae 10-20 part.
Can also add Borneolum Syntheticum 3-7 part or Cortex Dictamni 20-40 part or Fructus Forsythiae 10-20 part and Herba Patriniae 20-40 part with disease in the component of described weight portion raw material.
The preparation method of treatment female vagina inflammation washing liquid may further comprise the steps:
1) in the raw material of described component: behind the ratio prescription of 5% glacial acetic acid solution=1: 8, decocted 1 hour, the filter liquor body portion is stand-by;
2) Sheng Xia filtering residue adds 5% glacial acetic acid solution of 8 times of amounts again, decocts 1 hour, and the filter liquor body portion is stand-by;
3) Sheng Xia filtering residue adds 5% glacial acetic acid solution of 4 times of amounts again, decocts 1 hour, and it is stand-by to leach liquid; 4) merge the filtrate of above-mentioned steps gained, be concentrated into the raw medicinal herbs of 200mg/ml, add the sodium hydroxide solution adjust pH about 4.5 of 1mol/L again, cold preservation is filtered, the sterilization packing.
The compatibility of above-mentioned raw materials is owing to be main component with the berberine in Rhizoma Coptidis, the Cortex Phellodendri in the component, therefore extract higher by 25.2% with acid solution than putting forward the berberine yield with traditional water, higher by 14.7% than content of berberine with ethanol extraction, belong to preferred process, and suitable suitability for industrialized production.
The Fang Xieyu pharmacology analysis: traditional Chinese medicine theory thinks that gynecological inflammation mostly is hollow or have a delicate constitution usually through row, puerperal, vessels of the uterus, and evil poison is invaded in taking advantage of a weak point in opponent's defence, and turbid damp, pyretic toxicity pent up in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, and QI and blood is fought mutually, and good and evil intersect, disharmony of nutrient QI with defensive QI, hyperactivity of toxic heat.As " element is asked the regulating menstruation opinion ": " among the cold-damp people also, skin is not received, tightened muscle, flourish blood tears (puckery)." " element asks YIN YANG classification of natural phenomena big opinion ": " intenseness of heat is then swollen." as malpractice, with the passing of time the course of disease will delay.With the passing of time QI and blood is fought into the stasis of blood mutually, and weight in wet base is in heat, and it is long-pending to belong to the damp and hot stasis of blood, thereby causes through capable uncomfortable, profuse leukorrhea, and yellow skin is smelly, or lower abdominal pain.So heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, damp eliminating leukorrhagia stopping are principle of treatment.The present invention is according to the pathogen and pathology of tcm prescription, and Radix Sophorae Flavescentis comes from " Medical Treasures of the Golden Chamber Bulbus Lilii oral-anal-genital ulcer syndrome YIN YANG toxin syndrome abnormal pulse card is controlled " in the side, has the effect of heat clearing away, dampness, parasite killing; The sedimentation of Cortex Phellodendri bitter cold is longer than and is rushed down damp-heat in lower-JIAO clearly, and the effect of heat clearing and damp drying, eliminating fire and detoxication is arranged; The hot hardship of loosing of the Fructus Kochiae is fallen, and heat clearing away cold in nature has clearing away heat-damp and promoting diuresis, wind dispelling insecticide, antipruritic effect, and " not record " meaning Fructus Kochiae can " be removed the peel steam in the skin, diffusing malignant boil, hernia abdominal mass, reinforcing YIN-essence "; Dried Alumen has the effect of heat clearing and damp drying.Other each medicine reasonable compatibilities in the side reach inhibiting bacteria and diminishing inflammation, heat-clearing and toxic substances removing, dispeiling pathogenic wind and removing dampness, analgesia and end overworked whole excellent results.
The invention has the beneficial effects as follows: this washing liquid is obvious through the clinical verification therapeutic effect, can not cause damage to other organ of health, also is difficult for making pathogenic bacteria generation drug resistance and destroys the self-cleaning and defence capability of vagina; The thorough treatment of this washing liquid, administration time is short, and the state of an illness is difficult for repeatedly.By 300 routine clinical treatments, 127 examples of fully recovering, produce effects 114 examples, effective 45 examples, invalid 14 examples.Total effective rate is 95.3% to be higher than certain market gynecological lotion (total effective rate is 73.63%) in contrast.From relatively, both total effective rates have significant difference.Effect of the present invention is obviously better.
The specific embodiment
Embodiment 1, this routine washing liquid are particularly useful for treating trichomonal vaginitis except clinical common gynecologic inflammation is had the curative effect.Proportioning raw materials and preparation method are as follows:
Get 10 kilograms in 10 kilograms of Rhizoma Coptidis, 10 kilograms of Cortex Phellodendris, 10 kilograms of Radix Scutellariaes, 20 kilograms of Fructus Cnidiis, 20 kilograms of the Fructus Kochiae, 5 kilograms of dried Alumens, 20 kilograms of Herba Houttuyniae, 20 kilograms of Radix Sophorae Flavescentiss, 20 kilograms of Flos Chrysanthemi Indicis, 20 kilograms of Radix Gentianaes, 20 kilograms of Rhizoma Smilacis Glabraes, 10 kilograms of the Radixs Stemonae, 20 kilograms of Fructus Zanthoxylis, 20 kilograms of Herba Taraxacis, 15 kilograms of Radix Saposhnikoviaes, 20 kilograms of Boraxs, 10 kilograms of Herba Menthaes, 20 kilograms of Radix Angelicae Sinensis, 20 kilograms of Radix Arnebiae (Radix Lithospermi)s and Radix Glycyrrhizae, other adds 5 kilograms of Borneolum Syntheticums.
1) in the raw material of above-mentioned component: behind the ratio prescription of 5% glacial acetic acid solution=1: 8, decocted 1 hour, the filter liquor body portion is stand-by;
2) Sheng Xia filtering residue adds 5% glacial acetic acid solution of 8 times of amounts again, decocts 1 hour, and the filter liquor body portion is stand-by;
3) Sheng Xia filtering residue adds 5% glacial acetic acid solution of 4 times of amounts again, decocts 1 hour, and it is stand-by to leach liquid; 4) merge the filtrate of above-mentioned steps gained, be concentrated into the raw medicinal herbs of 200mg/ml, add the sodium hydroxide solution adjust pH about 4.5 of 1mol/L again, cold preservation is filtered, the sterilization packing.
Embodiment 2, this routine washing liquid are particularly useful for treating colpitis mycotica except clinical common gynecologic inflammation is had the curative effect.Proportioning raw materials is as follows:
Get 20 kilograms in 20 kilograms of Rhizoma Coptidis, 20 kilograms of Cortex Phellodendris, 20 kilograms of Radix Scutellariaes, 40 kilograms of Fructus Cnidiis, 40 kilograms of the Fructus Kochiae, 15 kilograms of dried Alumens, 40 kilograms of Herba Houttuyniae, 40 kilograms of Radix Sophorae Flavescentiss, 40 kilograms of Flos Chrysanthemi Indicis, 40 kilograms of Radix Gentianaes, 40 kilograms of Rhizoma Smilacis Glabraes, 20 kilograms of the Radixs Stemonae, 40 kilograms of Fructus Zanthoxylis, 40 kilograms of Herba Taraxacis, 25 kilograms of Radix Saposhnikoviaes, 40 kilograms of Boraxs, 20 kilograms of Herba Menthaes, 40 kilograms of Radix Angelicae Sinensis, 40 kilograms of Radix Arnebiae (Radix Lithospermi)s and Radix Glycyrrhizae, other adds 40 kilograms of Cortex Dictamni.
Preparation method is identical with embodiment 1.
Embodiment 3, this routine washing liquid are particularly useful for treating bacterial vaginitis except clinical common gynecologic inflammation is had the curative effect.Proportioning raw materials is as follows:
Get 15 kilograms in 15 kilograms of Rhizoma Coptidis, 15 kilograms of Cortex Phellodendris, 15 kilograms of Radix Scutellariaes, 30 kilograms of Fructus Cnidiis, 30 kilograms of the Fructus Kochiae, 10 kilograms of dried Alumens, 30 kilograms of Herba Houttuyniae, 30 kilograms of Radix Sophorae Flavescentiss, 30 kilograms of Flos Chrysanthemi Indicis, 30 kilograms of Radix Gentianaes, 30 kilograms of Rhizoma Smilacis Glabraes, 15 kilograms of the Radixs Stemonae, 30 kilograms of Fructus Zanthoxylis, 30 kilograms of Herba Taraxacis, 20 kilograms of Radix Saposhnikoviaes, 30 kilograms of Boraxs, 15 kilograms of Herba Menthaes, 30 kilograms of Radix Angelicae Sinensis, 30 kilograms of Radix Arnebiae (Radix Lithospermi)s and Radix Glycyrrhizae, other adds 30 kilograms of 15 kilograms of Fructus Forsythiaes and Herba Patriniae.
Preparation method is identical with embodiment 1.
The foregoing description microbiology test result:
| Strain name | Complete Mlc (mg/ml) | Part Mlc (mg/ml) |
| Pseudomonas aeruginosa | 12.5 | (6.25 by force) |
| Staphylococcus aureus | 50 | 25 (parts) |
| Escherichia coli | 25 | (12.5 part) |
| Bacillus pyogenes | 25 | (6.25 nothing) |
| Group B streptococcus | 25 | (12.5 nothing) |
Claims (2)
1. washing liquid for the treatment of female vagina inflammation, it is characterized in that it is the external wash liquid that is prepared into by following bulk drugs: Rhizoma Coptidis 10-20 part, Cortex Phellodendri 10-20 part, Radix Scutellariae 10-20 part, Fructus Cnidii 20-40 part, Fructus Kochiae 20-40 part, dried Alumen 5-15 part, Herba Houttuyniae 20-40 part, Radix Sophorae Flavescentis 20-40 part, Flos Chrysanthemi Indici 20-40 part, Radix Gentianae 20-40 part, Rhizoma Smilacis Glabrae 20-40 part, Radix Stemonae 10-20 part, Fructus Zanthoxyli 20-40 part, Herba Taraxaci 20-40 part, Radix Saposhnikoviae 15-25 part, Borax 20-40 part, Herba Menthae 10-20 part, Radix Angelicae Sinensis 20-40 part, Radix Arnebiae (Radix Lithospermi) 20-40 part, Radix Glycyrrhizae 10-20 part; The preparation method of this washing liquid is as follows
1) in the crude drug of described component: behind the ratio prescription of 5% glacial acetic acid solution=1: 8, decocted 1 hour, the filter liquor body portion is stand-by;
2) Sheng Xia filtering residue adds 5% glacial acetic acid solution of 8 times of amounts again, decocts 1 hour, and the filter liquor body portion is stand-by;
3) Sheng Xia filtering residue adds 5% glacial acetic acid solution of 4 times of amounts again, decocts 1 hour, and it is stand-by to leach liquid;
4) merge the filtrate of above-mentioned steps gained, be concentrated into the raw medicinal herbs of 200mg/ml, add the sodium hydroxide solution adjust pH 4.5 of 1mol/L again, cold preservation is filtered, the sterilization packing.
2. washing liquid for the treatment of female vagina inflammation, it is characterized in that, it is the external wash liquid that is prepared into by following bulk drugs: Rhizoma Coptidis 10-20 part, Cortex Phellodendri 10-20 part, Radix Scutellariae 10-20 part, Fructus Cnidii 20-40 part, Fructus Kochiae 20-40 part, dried Alumen 5-15 part, Herba Houttuyniae 20-40 part, Radix Sophorae Flavescentis 20-40 part, Flos Chrysanthemi Indici 20-40 part, Radix Gentianae 20-40 part, Rhizoma Smilacis Glabrae 20-40 part, Radix Stemonae 10-20 part, Fructus Zanthoxyli 20-40 part, Herba Taraxaci 20-40 part, Radix Saposhnikoviae 15-25 part, Borax 20-40 part, Herba Menthae 10-20 part, Radix Angelicae Sinensis 20-40 part, Radix Arnebiae (Radix Lithospermi) 20-40 part, Radix Glycyrrhizae 10-20 part, other adds Borneolum Syntheticum 3-7 part, or add Cortex Dictamni 20-40 part in addition, or add Fructus Forsythiae 10-20 part and Herba Patriniae 20-40 part jointly; The preparation method of this washing liquid is as follows
1) in the crude drug of described component: behind the ratio prescription of 5% glacial acetic acid solution=1: 8, decocted 1 hour, the filter liquor body portion is stand-by;
2) Sheng Xia filtering residue adds 5% glacial acetic acid solution of 8 times of amounts again, decocts 1 hour, and the filter liquor body portion is stand-by;
3) Sheng Xia filtering residue adds 5% glacial acetic acid solution of 4 times of amounts again, decocts 1 hour, and it is stand-by to leach liquid;
4) merge the filtrate of above-mentioned steps gained, be concentrated into the raw medicinal herbs of 200mg/ml, add the sodium hydroxide solution adjust pH 4.5 of 1mol/L again, cold preservation is filtered, the sterilization packing.
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| CN2009101011924A CN101612343B (en) | 2009-07-28 | 2009-07-28 | Lotion for treating female vagina inflammation |
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| CN2009101011924A CN101612343B (en) | 2009-07-28 | 2009-07-28 | Lotion for treating female vagina inflammation |
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| CN101612343B true CN101612343B (en) | 2011-09-14 |
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