CN106266557A - A kind of Chinese medicine preparation treating colpitis mycotica - Google Patents
A kind of Chinese medicine preparation treating colpitis mycotica Download PDFInfo
- Publication number
- CN106266557A CN106266557A CN201610646727.6A CN201610646727A CN106266557A CN 106266557 A CN106266557 A CN 106266557A CN 201610646727 A CN201610646727 A CN 201610646727A CN 106266557 A CN106266557 A CN 106266557A
- Authority
- CN
- China
- Prior art keywords
- parts
- herba
- radix
- chinese medicine
- medicine preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 title claims abstract description 79
- 238000002360 preparation method Methods 0.000 title claims abstract description 55
- 206010046914 Vaginal infection Diseases 0.000 title claims abstract description 20
- 210000000582 semen Anatomy 0.000 claims abstract description 24
- 241001252483 Kalimeris Species 0.000 claims abstract description 22
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 30
- 239000012567 medical material Substances 0.000 claims description 23
- 239000007788 liquid Substances 0.000 claims description 21
- 229940079593 drug Drugs 0.000 claims description 17
- 238000003756 stirring Methods 0.000 claims description 13
- 238000009835 boiling Methods 0.000 claims description 11
- 238000005119 centrifugation Methods 0.000 claims description 11
- -1 filters Substances 0.000 claims description 11
- 239000000706 filtrate Substances 0.000 claims description 11
- 230000001954 sterilising effect Effects 0.000 claims description 11
- 239000006228 supernatant Substances 0.000 claims description 11
- 239000012467 final product Substances 0.000 claims description 10
- 239000006210 lotion Substances 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 5
- 238000012545 processing Methods 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 4
- 244000130592 Hibiscus syriacus Species 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 2
- 239000000829 suppository Substances 0.000 claims description 2
- 244000025254 Cannabis sativa Species 0.000 claims 3
- 241000251468 Actinopterygii Species 0.000 claims 2
- 235000018081 Hibiscus syriacus Nutrition 0.000 claims 2
- 235000020995 raw meat Nutrition 0.000 claims 2
- 239000000084 colloidal system Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 38
- 231100000614 poison Toxicity 0.000 abstract description 21
- 239000003440 toxic substance Substances 0.000 abstract description 19
- 208000003251 Pruritus Diseases 0.000 abstract description 14
- 230000001737 promoting effect Effects 0.000 abstract description 14
- 210000003734 kidney Anatomy 0.000 abstract description 8
- 210000000952 spleen Anatomy 0.000 abstract description 8
- 230000007803 itching Effects 0.000 abstract description 7
- 230000008961 swelling Effects 0.000 abstract description 7
- 244000045947 parasite Species 0.000 abstract description 5
- 238000001035 drying Methods 0.000 abstract description 4
- 238000010792 warming Methods 0.000 abstract description 4
- 238000005728 strengthening Methods 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 description 21
- 235000019634 flavors Nutrition 0.000 description 21
- 239000008280 blood Substances 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 14
- 241000222122 Candida albicans Species 0.000 description 11
- 201000010099 disease Diseases 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 11
- 238000005406 washing Methods 0.000 description 10
- 238000012360 testing method Methods 0.000 description 9
- 210000001215 vagina Anatomy 0.000 description 9
- 230000017531 blood circulation Effects 0.000 description 8
- 235000009508 confectionery Nutrition 0.000 description 8
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 7
- 208000004880 Polyuria Diseases 0.000 description 7
- 229940095731 candida albicans Drugs 0.000 description 7
- 230000035619 diuresis Effects 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 206010067484 Adverse reaction Diseases 0.000 description 5
- 241000191967 Staphylococcus aureus Species 0.000 description 5
- 230000006838 adverse reaction Effects 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 206010007134 Candida infections Diseases 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 201000003984 candidiasis Diseases 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 206010007247 Carbuncle Diseases 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 241000607142 Salmonella Species 0.000 description 3
- 208000033809 Suppuration Diseases 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 210000005069 ears Anatomy 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 206010025482 malaise Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 208000037920 primary disease Diseases 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 240000006409 Acacia auriculiformis Species 0.000 description 2
- 241000345998 Calamus manan Species 0.000 description 2
- 206010012434 Dermatitis allergic Diseases 0.000 description 2
- 240000000691 Houttuynia cordata Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 2
- 241001071917 Lithospermum Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 201000008100 Vaginitis Diseases 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 201000008937 atopic dermatitis Diseases 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 230000009545 invasion Effects 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 230000003821 menstrual periods Effects 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 235000012950 rattan cane Nutrition 0.000 description 2
- 230000002787 reinforcement Effects 0.000 description 2
- 230000001568 sexual effect Effects 0.000 description 2
- 229940075582 sorbic acid Drugs 0.000 description 2
- 235000010199 sorbic acid Nutrition 0.000 description 2
- 239000004334 sorbic acid Substances 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 210000003905 vulva Anatomy 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 244000296912 Ageratum conyzoides Species 0.000 description 1
- 235000004405 Ageratum conyzoides Nutrition 0.000 description 1
- 244000066764 Ailanthus triphysa Species 0.000 description 1
- 241000219317 Amaranthaceae Species 0.000 description 1
- 241000093833 Aristolochia contorta Species 0.000 description 1
- 241000046617 Aristolochia debilis Species 0.000 description 1
- 241000758795 Aristolochiaceae Species 0.000 description 1
- 241000130784 Arnebia euchroma Species 0.000 description 1
- 241001050829 Arnebia guttata Species 0.000 description 1
- 241001008148 Aster indicus Species 0.000 description 1
- 241000994764 Brachystemma Species 0.000 description 1
- 235000016535 Capraria biflora Nutrition 0.000 description 1
- 208000001387 Causalgia Diseases 0.000 description 1
- 239000003390 Chinese drug Substances 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 244000241463 Cullen corylifolium Species 0.000 description 1
- 235000018274 Cunila origanoides Nutrition 0.000 description 1
- 244000182625 Dictamnus albus Species 0.000 description 1
- 235000014866 Dictamnus albus Nutrition 0.000 description 1
- 241000123855 Dictamnus dasycarpus Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 208000036649 Dysbacteriosis Diseases 0.000 description 1
- 208000027244 Dysbiosis Diseases 0.000 description 1
- 208000004483 Dyspareunia Diseases 0.000 description 1
- 206010014025 Ear swelling Diseases 0.000 description 1
- 235000015489 Emblica officinalis Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 241000221017 Euphorbiaceae Species 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 241000594394 Hedyotis Species 0.000 description 1
- 241000827798 Hemerocallis citrina Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 235000017309 Hypericum perforatum Nutrition 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 241000110847 Kochia Species 0.000 description 1
- 241001083838 Lardizabalaceae Species 0.000 description 1
- 241000830535 Ligustrum lucidum Species 0.000 description 1
- 241000729196 Lycopus lucidus Species 0.000 description 1
- 241000219071 Malvaceae Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 241001483116 Neopicrorhiza scrophulariiflora Species 0.000 description 1
- 240000001659 Oldenlandia diffusa Species 0.000 description 1
- 241000207834 Oleaceae Species 0.000 description 1
- 244000011358 Patrinia scabiosaefolia Species 0.000 description 1
- 235000009267 Patrinia scabiosaefolia Nutrition 0.000 description 1
- 240000009120 Phyllanthus emblica Species 0.000 description 1
- 244000038594 Phyllanthus urinaria Species 0.000 description 1
- 241001529246 Platymiscium Species 0.000 description 1
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 description 1
- 241001468611 Polygonatum cyrtonema Species 0.000 description 1
- 241000037826 Polygonatum kingianum Species 0.000 description 1
- 241000037831 Polygonatum sibiricum Species 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 241001107098 Rubiaceae Species 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 241000915604 Scutellaria barbata Species 0.000 description 1
- 241000767839 Semiaquilegia adoxoides Species 0.000 description 1
- 208000032023 Signs and Symptoms Diseases 0.000 description 1
- 241000533985 Silene baccifera Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 240000002299 Symphytum officinale Species 0.000 description 1
- 235000005865 Symphytum officinale Nutrition 0.000 description 1
- 240000004460 Tanacetum coccineum Species 0.000 description 1
- 240000000147 Torreya grandis Species 0.000 description 1
- 241000282459 Ursus thibetanus Species 0.000 description 1
- 201000007096 Vulvovaginal Candidiasis Diseases 0.000 description 1
- 206010047799 Vulvovaginitis trichomonal Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 208000014439 complex regional pain syndrome type 2 Diseases 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000007140 dysbiosis Effects 0.000 description 1
- 241001233957 eudicotyledons Species 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000008738 huangbai Substances 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 208000010553 multiple abscesses Diseases 0.000 description 1
- SRQKTCXJCCHINN-NYYWCZLTSA-N nifuratel Chemical compound O=C1OC(CSC)CN1\N=C\C1=CC=C([N+]([O-])=O)O1 SRQKTCXJCCHINN-NYYWCZLTSA-N 0.000 description 1
- 229960002136 nifuratel Drugs 0.000 description 1
- 238000009400 out breeding Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000008354 sodium chloride injection Substances 0.000 description 1
- GOLXNESZZPUPJE-UHFFFAOYSA-N spiromesifen Chemical compound CC1=CC(C)=CC(C)=C1C(C(O1)=O)=C(OC(=O)CC(C)(C)C)C11CCCC1 GOLXNESZZPUPJE-UHFFFAOYSA-N 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 208000002003 vulvitis Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/264—Aristolochia (Dutchman's pipe)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
nullThe present invention relates to a kind of Chinese medicine preparation treating colpitis mycotica，This Chinese medicine preparation is made up of the raw material of following weight proportion: Cortex Dictamni 140～160 parts、Radix Cucubali 140～160 parts、Herba Scutellariae Barbatae 90～110 parts、The Fructus Kochiae 90～110 parts、Herba Patriniae 90～110 parts、Cortex Hibisci 110～130 parts、Rhizoma Picrorhizae 140～160 parts、Radix Semiaquilegiae 90～110 parts、Herba Hedyotidis Diffusae 90～110 parts、Root of Indian kalimeris herb 80～100 parts、Caulis Sargentodoxae 80～100 parts、Herba Lycopi 70～90 parts、Folium Hibisci Mutabilis 70～90 parts、Cacumen Securinegae Suffruticosae 50～70 parts、Herba Aristolochiae 50～70 parts、Radix Arnebiae (Radix Lithospermi) 50～70 parts、Fructus Psoraleae 50～70 parts、Rhizoma Polygonati 80～100 parts、The Folium Ligustri Lucidi 70～90 parts、Herba Houttuyniae 50～70 parts、Fructus Aurantii 40～60 parts、Semen Torreyae 40～60 parts；Chinese medicine preparation of the present invention has effect of heat clearing and damp drying, removing toxic substances and promoting subsidence of swelling, warming the kidney and strengthening the spleen, killing parasites for relieving itching.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation treating colpitis mycotica, belong to the field of Chinese medicines.
Background technology
Colpitis mycotica is by the microbial Vulva vagina infection of Candida albicans, environment disruption unclean with pudendum, interior, anti-
The abuse of raw element has certain contact in rising trend, and sickness rate is higher than trichomonal vaginitis.Because of health weakness or
Intravaginal dysbacteriosis (as used broad ectrum antibiotic in a large number, vaginadouche overfrequency, the double infection of induction), menstrual phase use not
Vaginal candida amount reproduction that clean sanitary towel causes and fall ill.Clinical cardinal symptom: leucorrhoea grow in quantity, pudendum, pruritus of vagina,
Intravaginal secretions is sticky, white bean dregs shape or curdy, can see bud with pudendum, vagina causalgia, secretions plate coating checking
Born of the same parents and pseudohypha, primary disease sickness rate is high, has a strong impact on orthobiosis and the work of patient.
Treatment to this type of disease clinically, the general Western medicine (such as nifuratel capsule) using oral antiinflammatory and cooperation are killed
The carrying out of bacterium washing liquid is treated, but some patients life-time service antibiotic etc, easily produce drug resistance, particularly female reproduction
The special anatomical features in road, is easily caused recurrent exerbation, is difficult to cure.But at present active drug the most not yet occurs, traditional
Chinese medicine has the advantage of uniqueness in terms for the treatment of this type of disease, relative to Western medicine, has determined curative effect, and relapse rate is low, and poison is secondary
The advantage of little effect, the traditional Chinese medical science uses determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs to treat, can reach the purpose for the treatment of both the principal and secondary aspects of a disease.
Colpitis mycotica belongs to the categories such as Chinese medicine " pudendal pruritus ", " leukorrhagia ", the most caused by function of liver and spleen imbalance.Because of Liver Channel
Hot and suffocating, insufficiency of the spleen resulting in production of dampness, damp invasion of lower energizer, tying in external genitals, increasing for leukorrhagia so sending out, HUANGBAI(sic) is held concurrently mutually, makees, difficulty of the most very itching in the moon
Bear.Separately because pudendum is unclean, worm-eaten infects or damp-heat accumulation, caused by multiple abscess.Also have the cause person because deficiency of YIN blood is dry, disease regard sb. as an outsider pudendum or
Intravaginal pruritus, the most very itches unbearably, is on tenterhooks；Damp and hot person many with leucorrhea with yellow discharge, amount many.Damp and hot it mostly is mycotic vagina
Scorching endogenous cause of ill, poison heresy is its exopathogenic factor, jointly interacts and make conditions of patients touching both it, controls difficulty for a long time more.The wettest
The evil inevitable impairment of YIN of heat, thus cloudy wound occurs.Deficiency of the liver and kindey, essence and blood void is this pathogenetic endogenous cause of ill blood-deficiency and wind-dry less, the venation stasis of blood
Resistance, be primary disease pathology favourable turn, mend let out double executing, inside and outside rule together as Therapeutic Principle.Clearing heat and expelling damp, sterilizing and itch-relieving, nourishing the liver and kidney, support
Blood is invigorated blood circulation, for the Therapeutic Method of primary disease.Based on external treatment.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine preparation treating colpitis mycotica, this Chinese medicine preparation has curative effect
Significantly, the advantage that toxic and side effects is less, relapse rate is low.
Colpitic pathogenesis is the most damp and the hottest, and spleen, kidney two are empty caused, selects Cortex Dictamni heat clearing and damp drying in side；Radix Cucubali energy
Removing toxic substances and promoting subsidence of swelling；Be equipped with again Herba Scutellariae Barbatae, the Fructus Kochiae, Herba Patriniae, Cortex Hibisci four medicine share that heat-clearing and toxic substances removing holds concurrently can dampness removing；Rhizoma Picrorhizae can be clear
Damp and hot, Radix Semiaquilegiae, Herba Hedyotidis Diffusae, root of Indian kalimeris herb three medicine mutual reinforcement between are use, play the effect of heat-clearing and toxic substances removing, then select Caulis Sargentodoxae, Herba Lycopi,
The merit that reinforcement side's medicine is invigorated blood circulation, is aided with Folium Hibisci Mutabilis, Cacumen Securinegae Suffruticosae, Herba Aristolochiae, Radix Arnebiae (Radix Lithospermi) can blood-activating and qi-promoting, removing toxic substances and promoting subsidence of swelling；Side's medicine is equipped with
Fructus Psoraleae, Rhizoma Polygonati energy kidney and spleen invigorating, the equilibrium between yin and yang to regulate body of holding concurrently.Folium Ligustri Lucidi removing toxic substances dissipating blood stasis；Join Herba Houttuyniae again, Fructus Aurantii adds
Strong side medicine heat-clearing and toxic substances removing, be eventually adding Semen Torreyae and play the merit of killing parasites for relieving itching.All medicines share, and make full side play heat clearing and damp drying, removing toxic substances disappears
Swollen, the effect of warming the kidney and strengthening the spleen, killing parasites for relieving itching.For damp invasion of lower energizer, dai channel is failed to keep an appointment, leucorrhea with red and white discharge, and pudendal pruritus swelling of the vulva is mould microbial
Vaginitis, vulvitis etc..
The present invention treats the Chinese medicine preparation of colpitis mycotica and is made up of following crude drug: Cortex Dictamni, Radix Cucubali, half
Lotus, the Fructus Kochiae, Herba Patriniae, Cortex Hibisci, Rhizoma Picrorhizae, Radix Semiaquilegiae, Herba Hedyotidis Diffusae, root of Indian kalimeris herb, Caulis Sargentodoxae, Herba Lycopi, Folium Hibisci Mutabilis, leaf
Lower pearl, Herba Aristolochiae, Radix Arnebiae (Radix Lithospermi), Fructus Psoraleae, Rhizoma Polygonati, the Folium Ligustri Lucidi, Herba Houttuyniae, Fructus Aurantii, Semen Torreyae.
The present invention treats the Chinese medicine preparation of colpitis mycotica and is made up of the crude drug of following weight proportion: Cortex Dictamni
140～160 parts, Radix Cucubali 140～160 parts, Herba Scutellariae Barbatae 90～110 parts, the Fructus Kochiae 90～110 parts, Herba Patriniae 90～110 parts,
Cortex Hibisci 110～130 parts, Rhizoma Picrorhizae 140～160 parts, Radix Semiaquilegiae 90～110 parts, Herba Hedyotidis Diffusae 90～110 parts, root of Indian kalimeris herb
80～100 parts, Caulis Sargentodoxae 80～100 parts, Herba Lycopi 70～90 parts, Folium Hibisci Mutabilis 70～90 parts, Cacumen Securinegae Suffruticosae 50～70 parts, Herba Aristolochiae 50
～70 parts, Radix Arnebiae (Radix Lithospermi) 50～70 parts, Fructus Psoraleae 50～70 parts, Rhizoma Polygonati 80～100 parts, the Folium Ligustri Lucidi 70～90 parts, Herba Houttuyniae 50～70
Part, Fructus Aurantii 40～60 parts, Semen Torreyae 40～60 parts.
Preferably, Chinese medicine preparation of the present invention is made up of the crude drug of following weight proportion: Cortex Dictamni 150 parts, Radix Cucubali
150 parts, Herba Scutellariae Barbatae 100 parts, the Fructus Kochiae 100 parts, Herba Patriniae 100 parts, Cortex Hibisci 120 parts, Rhizoma Picrorhizae 150 parts, Radix Semiaquilegiae 100
Part, Herba Hedyotidis Diffusae 100 parts, root of Indian kalimeris herb 90 parts, Caulis Sargentodoxae 90 parts, Herba Lycopi 80 parts, Folium Hibisci Mutabilis 80 parts, Cacumen Securinegae Suffruticosae 60 parts, beauty
60 parts of rattan, Radix Arnebiae (Radix Lithospermi) 60 parts, Fructus Psoraleae 60 parts, Rhizoma Polygonati 90 parts, the Folium Ligustri Lucidi 80 parts, Herba Houttuyniae 60 parts, Fructus Aurantii 50 parts, Semen Torreyae 50 parts.
Preferably, Chinese medicine preparation of the present invention is made up of the crude drug of weight proportion: Cortex Dictamni 140 parts, Radix Cucubali 160
Part, Herba Scutellariae Barbatae 110 parts, the Fructus Kochiae 90 parts, Herba Patriniae 90 parts, Cortex Hibisci 130 parts, Rhizoma Picrorhizae 160 parts, Radix Semiaquilegiae 110 parts, spend in vain
Herba Hedyotidis Diffusae 110 parts, root of Indian kalimeris herb 100 parts, Caulis Sargentodoxae 80 parts, Herba Lycopi 90 parts, Folium Hibisci Mutabilis 90 parts, Cacumen Securinegae Suffruticosae 50 parts, Herba Aristolochiae 70 parts,
Radix Arnebiae (Radix Lithospermi) 50 parts, Fructus Psoraleae 70 parts, Rhizoma Polygonati 100 parts, the Folium Ligustri Lucidi 70 parts, Herba Houttuyniae 70 parts, Fructus Aurantii 60 parts, Semen Torreyae 60 parts.
Preferably, Chinese medicine preparation of the present invention is made up of the crude drug of weight proportion: Cortex Dictamni 160 parts, Radix Cucubali 140
Part, Herba Scutellariae Barbatae 90 parts, the Fructus Kochiae 110 parts, Herba Patriniae 110 parts, Cortex Hibisci 110 parts, Rhizoma Picrorhizae 140 parts, Radix Semiaquilegiae 90 parts, spend in vain
Herba Hedyotidis Diffusae 90 parts, root of Indian kalimeris herb 80 parts, Caulis Sargentodoxae 100 parts, Herba Lycopi 70 parts, Folium Hibisci Mutabilis 70 parts, Cacumen Securinegae Suffruticosae 70 parts, Herba Aristolochiae 50 parts,
Radix Arnebiae (Radix Lithospermi) 70 parts, Fructus Psoraleae 50 parts, Rhizoma Polygonati 80 parts, the Folium Ligustri Lucidi 90 parts, Herba Houttuyniae 50 parts, Fructus Aurantii 40 parts, Semen Torreyae 40 parts.
The active Chinese drug component component of the present invention can add various adjuvants conventional on pharmaceutics, with conventional Chinese medicine preparation side
Method is prepared as external preparation, such as dosage forms such as lotion, gel, suppositorys.
Described Chinese medicine preparation dosage form is preferably lotion.
The present invention states the preparation method of Chinese medicine preparation, is made up of following processing step:
Take Cortex Dictamni, Radix Cucubali, Herba Scutellariae Barbatae, the Fructus Kochiae, Herba Patriniae, Cortex Hibisci, Rhizoma Picrorhizae, Radix Semiaquilegiae, Herba Hedyotidis Diffusae,
Root of Indian kalimeris herb, Caulis Sargentodoxae, Herba Lycopi, Folium Hibisci Mutabilis, Cacumen Securinegae Suffruticosae, Herba Aristolochiae, Radix Arnebiae (Radix Lithospermi), Fructus Psoraleae, Rhizoma Polygonati, the Folium Ligustri Lucidi, Herba Houttuyniae, Fructus Aurantii,
Semen Torreyae, boiling secondary, add the water of medical material weight 8～12 times amount for the first time, decocting time is 0.5～2 hour, for the second time
Adding the water of medical material weight 7～9 times amount, decocting time is 0.5～2 hour, merges twice decocting liquid, filters, and filtrate is condensed into phase
To the clear paste that density is 1.05～1.10, stir, stand 8～16 hours, filter, centrifugal treating, centrifugal speed 2000
～4000rpm, centrifugation time 10～20min, take supernatant, subpackage, sterilizing, to obtain final product.
Preferably, the present invention states the preparation method of Chinese medicine preparation, is made up of following processing step:
Take Cortex Dictamni, Radix Cucubali, Herba Scutellariae Barbatae, the Fructus Kochiae, Herba Patriniae, Cortex Hibisci, Rhizoma Picrorhizae, Radix Semiaquilegiae, Herba Hedyotidis Diffusae,
Root of Indian kalimeris herb, Caulis Sargentodoxae, Herba Lycopi, Folium Hibisci Mutabilis, Cacumen Securinegae Suffruticosae, Herba Aristolochiae, Radix Arnebiae (Radix Lithospermi), Fructus Psoraleae, Rhizoma Polygonati, the Folium Ligustri Lucidi, Herba Houttuyniae, Fructus Aurantii,
Semen Torreyae, boiling secondary, add the water of medical material weight 10 times amount for the first time, decocting time is 1 hour, and second time adds medical material
The water of weight 8 times amount, decocting time is 1 hour, merges twice decocting liquid, filter, filtrate be condensed into relative density be 1.05～
The clear paste of 1.10, stirs, and stands 12 hours, filters, centrifugal treating, centrifugal speed 3000rpm, centrifugation time 15min,
Take supernatant, subpackage, sterilizing, to obtain final product.
Fang Zhong each side medicine source, nature and flavor and efficacy effect are as follows:
Cortex Dictamni, for the dry root bark of rutaceae shaggy-fruited dittany Dictamnus dasycarpus Turcz..Nature and flavor, bitter,
Cold.Effect, heat clearing and damp drying, removing toxic substances of dispeling the wind.
Radix Cucubali, for the root of pinkwort Cucubalus baccifer Brachystemma calycinu D.Don.Nature and flavor, sweet, bitter,
Property flat.Effect, blood circulation promoting and blood stasis dispelling, treating stranguria let out turbid, removing toxic substances and promoting subsidence of swelling.
Herba Scutellariae Barbatae, for the dry herb of labiate Herba Scutellariae Barbatae Scutellaria barbata Don.Nature and flavor, pungent,
Hardship, cold.Effect, heat-clearing and toxic substances removing, blood stasis dispelling diuresis.
The Fructus Kochiae, for the dry mature fruit of chenopod Fructus Kochiae Kochia scoparia (L) Schrad..Nature and flavor, pungent,
Hardship, cold.Effect, clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.
Herba Patriniae, for Herba Patriniae section plant Hemerocallis citrina Baroni dragon bud Patrinia scabiosaefolia Fisch.ex Link. with
Root stock and root, all herbal medicine.Nature and flavor, pungent, bitter, cool.Effect, heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.
Cortex Hibisci, for peel of stem or the root bark of Malvaceae Hibiscus plant Hibiscus syriacus L. Hibiscus syriacus L..Nature and flavor,
Sweet, tepor.Effect, clearing away heat-damp and promoting diuresis, killing parasites for relieving itching.
Rhizoma Picrorhizae, for the dry root of goatweed Rhizoma Picrorhizae Picrorhiza scrophulariiflora Pennell
Stem.Nature and flavor, bitter, cold.Effect, clearing away damp-heat, except hectic fever due to YIN-deficiency, disappear infantile malnutrition with fever.
Radix Semiaquilegiae, for the dried root of ranunculaceae plant Radix Semiaquilegiae Semiaquilegia adoxoides (DC.) Makino.
Nature and flavor, sweet, bitter, cold.Effect, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.
Herba Hedyotidis Diffusae, for the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae Hedyotis diffusa Willd..
Nature and flavor, sweet, light, cool.Effect, heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.
Root of Indian kalimeris herb, for herb and the root of feverfew Herba Kalimeridis Kalimeris indica (L.) Sch.-Bip.Nature and flavor, pungent,
Hardship, cold.Effect, heat-clearing and toxic substances removing, dissipating blood stasis stops blooding, removing food stagnancy.
Caulis Sargentodoxae, for the rattan of dicotyledon medicine plants of Lardizabalaceae Caulis Sargentodoxae Caulis Sargentodoxae.Nature and flavor: taste
Hardship, flat.Function: promoting blood circulation to remove obstruction in the collateral, relieve internal heat dissipating blood stasis, wind dispelling insecticide.
Herba Lycopi, for labiate hair leaf lycopus lucidus Lycopus lucidus Turcz.var.hirtus Regel's
Dry aerial parts.Nature and flavor, bitter, pungent, tepor.Effect, blood circulation promoting and blood stasis dispelling, line water detumescence.
Folium Hibisci Mutabilis, for the blade of Malvaceae plant Hibisci Mutabilis.Nature and flavor, pungent, flat.Function cures mainly, removing heat from blood, removing toxic substances, detumescence,
Pain relieving.
Cacumen Securinegae Suffruticosae, for Euphorbiaceae phyllanthus emblica platymiscium Cacumen Securinegae Suffruticosae Phyllanthus urinaria L., with all herbal medicine.Property
Taste, micro-hardship, sweet, cool.Effect, clearing away heat and promoting diuresis, improving eyesight, removing food stagnancy.
Herba Aristolochiae, for aristolochiaceae plant Fructus Aristolochiae Aristolochia debilis Sieb.et Zucc. or north horse pocket
The dry aerial parts of bell Aristolochia contorta Bunge..Nature and flavor, bitter, temperature.Effect, promoting flow of QI and blood, diuretic disappears
Swollen.
Radix Arnebiae (Radix Lithospermi), for comfrey lithospermum euchromum Royle Radix Arnebiae (Radix Lithospermi) Lithospermum erythrorhizon Sieb.et
Zucc.Arnebia euchroma (Royle) Johnst. or the dry root of arnebia guttata Bunge Arnebia guttata Bunge.
Nature and flavor, sweet, salty, cold.Effect, removing heat from blood, invigorate blood circulation, rash of detoxifying.
Fructus Psoraleae, the dry mature fruit of legumes psoraleae Psoralea corylifolia L..Nature and flavor, pungent,
Hardship, temperature.Effect, warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.
Rhizoma Polygonati, for liliaceous plant P. kingianum Polygonatum kingianum Coll.et Hemsl., Rhizoma Polygonati
Polygonatum sibiricum Red. or the dry rhizome of Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua.Nature and flavor,
Sweet, flat.Effect, boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.
The Folium Ligustri Lucidi, the blade of Oleaceae plants Fructus Ligustri Lucidi Ligustrum lucidum Ait., can adopt the whole year.Nature and flavor, bitter, property
Cool.Effect, clearing away heat to improve acuity of vision, detoxify dissipating blood stasis；Detumescence cough-relieving.
Herba Houttuyniae, for the dry aerial parts of saururaceae plant houttuynia cordata Houttuynia cordata Thunb..Property
Taste, pungent, it is slightly cold.Effect, heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.
Fructus Aurantii, for the dry aerial parts of saururaceae plant houttuynia cordata Houttuynia cordata Thunb..Nature and flavor,
Pungent, it is slightly cold.Effect, heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.
Semen Torreyae, for the dry mature seed of taxaceae plant Chinese torreya Torreya grandis Fort..Nature and flavor, sweet, flat.
Effect, killing insect and eliminating accumulation, moistening dryness for relaxing bowels.
The beneficial effect of Chinese medicine preparation of the present invention:
Each crude drug component in Chinese medicine preparation of the present invention and proportioning thereof, be through facing for many years through present inventor
Bed summary of experience gropes out.Its each medical material compatibility so that full side has the effect of Synergistic.All medicines share plays heat clearing away altogether
Dampness, removing toxic substances and promoting subsidence of swelling, warming the kidney and strengthening the spleen, effect of killing parasites for relieving itching.Pharmacodynamic experiment result shows, having of Chinese medicine preparation of the present invention
Broad-spectrum antibacterial action, but to Candida albicans and staphylococcus aureus best results, the most obvious antiinflammatory action.Warp
Clinical trial is verified, the middle preparation of the present invention can improve the clinical symptoms of colpitis mycotica patient, and its total effective rate is
91.4%, and clinical effective rate is better than matched group (woman's inflammation is clean).The adverse reaction rate of Chinese medicine preparation of the present invention and relapse rate
It is respectively 1.1% and 1.2%.In sum, Chinese medicine preparation of the present invention has evident in efficacy, and side effect is little, low excellent of relapse rate
Point.Chinese medicine preparation of the present invention treatment colpitis mycotica, it is possible to the clinical symptoms of reduction of patient, has huge application prospect.
Pharmacological experiment
1. test material
1.1 medicines and reagent
The preparation of Chinese medicine preparation of the present invention 1 group
Take Cortex Dictamni 150g, Radix Cucubali 150g, Herba Scutellariae Barbatae 100g, Fructus Kochiae 100g, Herba Patriniae 100g, Cortex Hibisci 120g,
Rhizoma Picrorhizae 150g, Radix Semiaquilegiae 100g, Herba Hedyotidis Diffusae 100g, root of Indian kalimeris herb 90g, Caulis Sargentodoxae 90g, Herba Lycopi 80g, Folium Hibisci Mutabilis 80g, leaf
Lower pearl 60g, Herba Aristolochiae 60g, Radix Arnebiae (Radix Lithospermi) 60g, Fructus Psoraleae 60g, Rhizoma Polygonati 90g, Folium Ligustri Lucidi 80g, Herba Houttuyniae 60g, Fructus Aurantii 50g, Semen Torreyae
50g, boiling secondary, add the water of medical material weight 10 times amount for the first time, decocting time is 1 hour, and second time adds medical material
The water of weight 8 times amount, decocting time is 1 hour, merges twice decocting liquid, filter, filtrate be condensed into relative density be 1.05～
The clear paste of 1.10, stirs, and stands 12 hours, filters, centrifugal treating, centrifugal speed 3000rpm, centrifugation time 15min,
Take supernatant, to obtain final product.
The preparation of Chinese medicine preparation of the present invention 2 groups
Take Cortex Dictamni 140g, Radix Cucubali 160g, Herba Scutellariae Barbatae 110g, Fructus Kochiae 90g, Herba Patriniae 90g, Cortex Hibisci 130g, recklessly
Rhizoma Coptidis 160g, Radix Semiaquilegiae 110g, Herba Hedyotidis Diffusae 110g, root of Indian kalimeris herb 100g, Caulis Sargentodoxae 80g, Herba Lycopi 90g, Folium Hibisci Mutabilis 90g, leaf
Lower pearl 50g, Herba Aristolochiae 70g, Radix Arnebiae (Radix Lithospermi) 50g, Fructus Psoraleae 70g, Rhizoma Polygonati 100g, Folium Ligustri Lucidi 70g, Herba Houttuyniae 70g, Fructus Aurantii 60g, Semen Torreyae
60g；Boiling secondary, adds the water of medical material weight 8 times amount for the first time, and decocting time is 0.5 hour, and second time adds medical material
The water of weight 9 times amount, decocting time is 2 hours, merges twice decocting liquid, filter, filtrate be condensed into relative density be 1.05～
The clear paste of 1.10, stirs, and stands 16 hours, filters, centrifugal treating, centrifugal fast 4000rpm, centrifugation time 10min, takes
Supernatant, to obtain final product.
The preparation of Chinese medicine preparation of the present invention 3 groups
Take Cortex Dictamni 160g, Radix Cucubali 140g, Herba Scutellariae Barbatae 90g, Fructus Kochiae 110g, Herba Patriniae 110g, Cortex Hibisci 110g, recklessly
Under Rhizoma Coptidis 140g, Radix Semiaquilegiae 90g, Herba Hedyotidis Diffusae 90g, root of Indian kalimeris herb 80g, Caulis Sargentodoxae 100g, Herba Lycopi 70g, Folium Hibisci Mutabilis 70g, leaf
Pearl 70g, Herba Aristolochiae 50g, Radix Arnebiae (Radix Lithospermi) 70g, Fructus Psoraleae 50g, Rhizoma Polygonati 80g, Folium Ligustri Lucidi 90g, Herba Houttuyniae 50g, Fructus Aurantii 40g, Semen Torreyae
40g, boiling secondary, add the water of medical material weight 12 times amount for the first time, decocting time is 2 hours, and second time adds medical material
The water of weight 7 times amount, decocting time is 0.5 hour, merges twice decocting liquid, filter, filtrate be condensed into relative density be 1.05～
The clear paste of 1.10, stirs, and stands 8 hours, filters, centrifugal treating, centrifugal speed 2000rpm, centrifugation time 20min,
Take supernatant, to obtain final product.
1.2 animals and bacterial strain
Closed colony, outbreeding system Kunming mouse, cleaning grade, male and female dual-purpose, body weight 20～25g；For Shaanxi university of TCM
Experimental Animal Center provides.Reference culture: staphylococcus aureus, Candida albicans, escherichia coli, salmonella, Aerugo vacation list
Born of the same parents bacterium (Nat'l Pharmaceutical & Biological Products Control Institute's offer).
1.3 medicines and reagent
The scorching clean washing liquid (Renhe, Jiangxi pharmaceutcal corporation, Ltd) of woman, dimethylbenzene, (Chengdu Ke Long chemical reagent factory), injection
Water, sodium chloride injection, (Hangzhou Minsheng Medcine Co., Ltd).
2. test method
2.1 antibacterial experiment in vitro:
Taking 11 sterilizing test tubes, often pipe adds people's culture medium 4.0ml, adds medicinal liquid 4.0ml, draw after mixing in l pipe
4.0ml, adds in the 2nd pipe, is diluted to the 10th pipe with method.Blank from the 10th pipe sucking-off 4.0mL conduct in a sterilizing sky test tube
Comparison (being not added with bacterium solution), the 11st pipe is Growth positive control tube.The liquor strength of 1～10 pipes is 50,25,12.5,6.25,
3.12,1.56,0.78,0.39,0.19,0.10% (mL/mL).Add people's bacterium solution: take the bacterium solution position 0.2mL of 10-5 dilution level in respectively
In antibacterial test tube and positive test tube.Cultivating: take above-mentioned each test tube, Candida albicans cultivates 24h, Staphylococcus aureus in 26 DEG C
Bacterium, Candida albicans, pseudomonas aeruginosa, salmonella and escherichia coli cultivate 24h in 36 DEG C.
Table 1 minimum antibacterial (MIC) measurement result
As seen from the results in Table 1, Chinese medicine preparation of the present invention 1 group, 2 groups, 3 groups, to staphylococcus aureus, Candida albicans,
Pseudomonas aeruginosa, salmonella, escherichia coli all have inhibitory action in various degree, especially to staphylococcus aureus and white
The inhibitory action of candidiasis is the strongest.This also indicates that, invention formulation has good controlling to infectious disease caused by Candida albicans
Treatment effect.
2.2 xylol cause the effect of mice ear
Taking Kun Ming mice 50, male and female half and half, weight is (20 ± 2) g, is randomly divided into 5 groups, and often group 10 is moved
Thing, group be respectively as follows: 1 group be normal saline blank group, matched group (woman scorching clean washing liquid), Chinese medicinal lotion of the present invention 1 group, 2 groups, 3
Group, each group all use smears administration, medicaments uniformity is applied in left ear tow sides, within one day, is administered 3 times, every minor tick 30min,
Successive administration 7d.30min after last administration, after removing medicine with warm water wiping, smears 100% cause scorching on animal subject left ear two sides
Agent dimethylbenzene, only, auris dextra is left intact 0.1ml/, is coated with said medicine immediately, repeats coating one after 30min after injection
Secondary.The neck that broken by mice after lh is put to death, and cuts two ears along auricle baseline, takes left and right ear same area respectively with diameter 6mm card punch
Auricle, weighs weight in the balance.Using the left auricle of every Mus and the difference of auris dextra sheet weight as swollen degree.
The impact of the mice ear that table 2 xylol causes
Note: compare with blank group, * P < 0.05, compare with matched group,△P<0.05。
As seen from the results in Table 2, comparing with blank group, (woman is scorching for Chinese medicine Chinese medicine preparation of the present invention 1 group, 2 groups, 3 groups and matched group
Clean washing liquid), xylol induced mice ear swelling has inhibitory action (P < 0.05 or P ＞ 0.05) in various degree.This explanation, this
Invention Chinese medicine preparation has the most antibacterial and antiinflammatory action.This experimental result, the clinical practice for Chinese medicine preparation of the present invention carries
Supply further theoretical foundation.
Detailed description of the invention
The following is the specific embodiment of present invention, for illustrating the skill of technical problem to be solved in present specification
Art scheme, contributes to skilled artisan understands that present invention, but the realization of technical solution of the present invention is not limited to these
Embodiment.
Embodiment 1
Take Cortex Dictamni 150g, Radix Cucubali 150g, Herba Scutellariae Barbatae 100g, Fructus Kochiae 100g, Herba Patriniae 100g, Cortex Hibisci 120g,
Rhizoma Picrorhizae 150g, Radix Semiaquilegiae 100g, Herba Hedyotidis Diffusae 100g, root of Indian kalimeris herb 90g, Caulis Sargentodoxae 90g, Herba Lycopi 80g, Folium Hibisci Mutabilis 80g, leaf
Lower pearl 60g, Herba Aristolochiae 60g, Radix Arnebiae (Radix Lithospermi) 60g, Fructus Psoraleae 60g, Rhizoma Polygonati 90g, Folium Ligustri Lucidi 80g, Herba Houttuyniae 60g, Fructus Aurantii 50g, Semen Torreyae
50g, boiling secondary, add the water of medical material weight 10 times amount for the first time, decocting time is 1 hour, and second time adds medical material
The water of weight 8 times amount, decocting time is 1 hour, merges twice decocting liquid, filter, filtrate be condensed into relative density be 1.05～
The clear paste of 1.10, stirs, and stands 12 hours, filters, centrifugal treating, centrifugal speed 3000rpm, centrifugation time 15min,
Taking supernatant, add sorbic acid, regulation pH value, to 4.0～5.5, adds water and makes Chinese medicinal lotion, stir evenly, subpackage, sterilizing, i.e.
?.
Embodiment 2
Take Cortex Dictamni 140g, Radix Cucubali 160g, Herba Scutellariae Barbatae 110g, Fructus Kochiae 90g, Herba Patriniae 90g, Cortex Hibisci 130g, recklessly
Rhizoma Coptidis 160g, Radix Semiaquilegiae 110g, Herba Hedyotidis Diffusae 110g, root of Indian kalimeris herb 100g, Caulis Sargentodoxae 80g, Herba Lycopi 90g, Folium Hibisci Mutabilis 90g, leaf
Lower pearl 50g, Herba Aristolochiae 70g, Radix Arnebiae (Radix Lithospermi) 50g, Fructus Psoraleae 70g, Rhizoma Polygonati 100g, Folium Ligustri Lucidi 70g, Herba Houttuyniae 70g, Fructus Aurantii 60g, Semen Torreyae
60g；Boiling secondary, adds the water of medical material weight 8 times amount for the first time, and decocting time is 0.5 hour, and second time adds medical material
The water of weight 9 times amount, decocting time is 2 hours, merges twice decocting liquid, filter, filtrate be condensed into relative density be 1.05～
The clear paste of 1.10, stirs, and stands 16 hours, filters, centrifugal treating, centrifugal fast 4000rpm, centrifugation time 10min, takes
Supernatant, adds glycerol, PEG-4000, makes gel, subpackage, sterilizing, to obtain final product.
Embodiment 3
Take Cortex Dictamni 160g, Radix Cucubali 140g, Herba Scutellariae Barbatae 90g, Fructus Kochiae 110g, Herba Patriniae 110g, Cortex Hibisci 110g, recklessly
Under Rhizoma Coptidis 140g, Radix Semiaquilegiae 90g, Herba Hedyotidis Diffusae 90g, root of Indian kalimeris herb 80g, Caulis Sargentodoxae 100g, Herba Lycopi 70g, Folium Hibisci Mutabilis 70g, leaf
Pearl 70g, Herba Aristolochiae 50g, Radix Arnebiae (Radix Lithospermi) 70g, Fructus Psoraleae 50g, Rhizoma Polygonati 80g, Folium Ligustri Lucidi 90g, Herba Houttuyniae 50g, Fructus Aurantii 40g, Semen Torreyae
40g, boiling secondary, add the water of medical material weight 12 times amount for the first time, decocting time is 2 hours, and second time adds medical material
The water of weight 7 times amount, decocting time is 0.5 hour, merges twice decocting liquid, filter, filtrate be condensed into relative density be 1.05～
The clear paste of 1.10, stirs, and stands 8 hours, filters, centrifugal treating, centrifugal speed 2000rpm, centrifugation time 20min,
Take supernatant, magnesium stearate, carbomer, make Chinese medicine suppository, subpackage, sterilizing, to obtain final product.
Embodiment 4
Take Cortex Dictamni 155g, Radix Cucubali 145g, Herba Scutellariae Barbatae 95g, Fructus Kochiae 105g, Herba Patriniae 105g, Cortex Hibisci 115g, recklessly
Rhizoma Coptidis 135g, Radix Semiaquilegiae 95g, Herba Hedyotidis Diffusae 95g, root of Indian kalimeris herb 85g, Caulis Sargentodoxae 95g, Herba Lycopi 75g, Folium Hibisci Mutabilis 75g, Cacumen Securinegae Suffruticosae
65g, Herba Aristolochiae 55g, Radix Arnebiae (Radix Lithospermi) 65g, Fructus Psoraleae 55g, Rhizoma Polygonati 85g, Folium Ligustri Lucidi 85g, Herba Houttuyniae 55g, Fructus Aurantii 45g, Semen Torreyae 45g,
Boiling secondary, adds the water of medical material weight 10 times amount for the first time, and decocting time is 1 hour, and second time adds medical material weight 8
The water of times amount, decocting time is 1 hour, merges twice decocting liquid, filter, filtrate be condensed into relative density be 1.05～1.10 clear
Cream, stirs, and stands 12 hours, filters, subpackage, centrifugal treating, centrifugal speed 2500rpm, centrifugation time 10min, takes
Supernatant, adds sorbic acid, and regulation pH value, to 4.0～5.5, adds water and makes Chinese medicinal lotion, stir evenly, subpackage, sterilizing, to obtain final product.
In order to verify the curative effect of finished product preparation of the present invention further, we are by the Chinese medicine of preparation in above-mentioned specific embodiment 1
Washing liquid, has carried out corresponding clinical trial, now result is reported as follows.
2 clinical observations and curative effect
2.1 physical data
Choose the patient accepted for medical treatment in March ,-2016 in January, 2015, be married woman, according to clinical symptoms, sign and thin
Mycology inspection is diagnosed as vaginitis patient 181 example.Being classified as treatment group and matched group, wherein treatment group 93 example, age are 24
～56 years old, year mean age (38.2 ± 1.8)；Course of disease 5d～5 years, average course of disease 2.1 ± 0.5) year, matched group 88 example, the age
25～58 years old, year mean age (39.1 ± 2.1)；Course of disease 3d～5 years, average course of disease (2.4 ± 0.3) year；Two groups of patients exist
The aspect comparing difference not statistically significant such as age, the course of disease (P ＞ 0.05), have comparability.
2.2 diagnostic criteria
Patient mainly shows as pudendum burn feeling companion's pruritus of vagina, leucorrhoea grow in quantity, frequent micturition, urgent micturition, dyspareunia, and gynecological examines
Looking into, it is seen that vulvovaginal mucosa edema, flushing, secretions is typical Glycine max (L.) Merr. or curdy.Lab testing: take vagina
Secretions is placed on the microscope slide of 0.9% normal saline, and microscopy sees that spore or mycelia person are diagnosed as colpitis mycotica.
Exclusion standard: with diabetic history, accepts antibiotic therapy, pregnancy period and age of sucking for a long time, with the organic disease such as liver, kidney
Disease, the patient of severe mental disturbances disease.
2.3 Therapeutic Method
2.3.1 matched group
The patient of matched group uses vagina after woman's scorching clean washing liquid (Renhe, Jiangxi pharmaceutcal corporation, Ltd) flushing, avoids menstrual period, and 2
Week is 1 course for the treatment of, continuously 3 courses for the treatment of of treatment.
2.3.2 treatment group
The patient for the treatment of group, before medication, dries after cleaning pudendum with water, takes Chinese medicine prepared by the embodiment of the present invention 1 method
Washing liquid 10ml washing vagina is in dilution bottle, and warm water, to 100ml, shakes up, with dilution after medicine liquid washing V&V,
2 times on the one.During treatment, forbid sexual life.During treatment, change underwear every day, and used underwear, towel carried out disinfection,
Fasting pungent stimulation food.Forbidden sexual life, forbids bath in a tub, swimming.Such as menstrual period only with warm water drip washing pudendum, forbidden vagina rushes
Wash, can continual cure after clean period 2d.It within 2 weeks, it is 1 course for the treatment of, after treating 3 courses for the treatment of continuously, it is judged that curative effect.
2.4 curative effect determinate standard
Effective: the sings and symptoms of patient is wholly absent, vaginal secretions candidiasis, negative fungal examination, pudendum
Cleannes I degree；Effective: the sings and symptoms of patient is obviously improved, candidiasis, negative fungal examination, pudendum cleaning degree II
Degree；Invalid: clinical symptoms and the sign of patient even increase the weight of without improving, and candidiasis, fungus microscope examination are positive.
2.5 statistical procedures
Using statistic software SPSS A13.0 software data processing, use X 2 test, P < 0.05 is statistically significant.
3 results
3.1 result of the tests are shown in Table 3.
The Clinical efficacy comparison of 3 liang of table group patient
Note: compare with matched group,△P<0.05。
As shown in Table 3, after the treatment of 3 courses for the treatment of, the total effective rate for the treatment of group patient is 91.4%, and right
Being only 70.5% according to group, the clinical efficacy for the treatment of group patient is better than matched group.
Adverse reaction rate and the relapse rate of 3.2 liang of group patients compare
In two groups of drug therapy clinical are observed, there is pudendum allergic dermatitis in treatment group 1 example patient, and untoward reaction occurs
Feeling sick, occur in rate 1.1%, and the patient of matched group (woman's inflammation is clean), and inappetence has 2 examples, and stomachache occurs in 1 example, and pudendum occur in 3 examples
Allergic dermatitis, altogether 6 example, incidence rate 6.8%, after drug withdrawal, two groups of adverse reactions of patients are all died away, the most now irreversibility
Serious adverse reaction, two groups of adverse reactions of patients incidence rates compare, and difference has statistical significance (P < 0.05).
Treating the therapeutic effect to two groups of patients after terminating, the tracking carried out 3 months is followed up a case by regular visits to, and matched group recurs 9 examples, recurrence
Rate 14.5%, treatment group Patients on Recurrence 1 example, relapse rate 1.2%, two groups of patient clinical therapeutic effect compare, and difference has statistics
Learn meaning (P < 0.05).
In sum, the Chinese medicine preparation of the present invention, to colpitis mycotica patient, has significant curative effect, its preparation technology
Simply, stable, feasible.This Chinese medicine preparation also further illustrating the present invention has good market application foreground.
Claims (9)
1. the Chinese medicine preparation treating colpitis mycotica, it is characterised in that it is made up of following crude drug: Cortex Dictamni,
Radix Cucubali, Herba Scutellariae Barbatae, the Fructus Kochiae, Herba Patriniae, Cortex Hibisci, Rhizoma Picrorhizae, Radix Semiaquilegiae, Herba Hedyotidis Diffusae, root of Indian kalimeris herb, Caulis Sargentodoxae, Herba Lycopi,
Folium Hibisci Mutabilis, Cacumen Securinegae Suffruticosae, Herba Aristolochiae, Radix Arnebiae (Radix Lithospermi), Fructus Psoraleae, Rhizoma Polygonati, the Folium Ligustri Lucidi, Herba Houttuyniae, Fructus Aurantii, Semen Torreyae.
2. treat the Chinese medicine preparation of colpitis mycotica as claimed in claim 1, it is characterised in that it is by following weight proportion
Crude drug composition: Cortex Dictamni 140～160 parts, Radix Cucubali 140～160 parts, Herba Scutellariae Barbatae 90～110 parts, the Fructus Kochiae 90～110
Part, Herba Patriniae 90～110 parts, Cortex Hibisci 110～130 parts, Rhizoma Picrorhizae 140～160 parts, Radix Semiaquilegiae 90～110 parts, Herba Hedyotidis Diffusae
Under grass 90～110 parts, root of Indian kalimeris herb 80～100 parts, Caulis Sargentodoxae 80～100 parts, Herba Lycopi 70～90 parts, Folium Hibisci Mutabilis 70～90 parts, leaf
Pearl 50～70 parts, Herba Aristolochiae 50～70 parts, Radix Arnebiae (Radix Lithospermi) 50～70 parts, Fructus Psoraleae 50～70 parts, Rhizoma Polygonati 80～100 parts, the Folium Ligustri Lucidi 70
～90 parts, Herba Houttuyniae 50～70 parts, Fructus Aurantii 40～60 parts, Semen Torreyae 40～60 parts.
3. treat the Chinese medicine preparation of colpitis mycotica as claimed in claim 2, it is characterised in that it is by following weight proportion
Crude drug composition: Cortex Dictamni 150 parts, Radix Cucubali 150 parts, Herba Scutellariae Barbatae 100 parts, the Fructus Kochiae 100 parts, Herba Patriniae 100 parts, Hibiscus syriacus L.
Skin 120 parts, Rhizoma Picrorhizae 150 parts, Radix Semiaquilegiae 100 parts, Herba Hedyotidis Diffusae 100 parts, root of Indian kalimeris herb 90 parts, Caulis Sargentodoxae 90 parts, Herba Lycopi 80 parts,
Folium Hibisci Mutabilis 80 parts, Cacumen Securinegae Suffruticosae 60 parts, Herba Aristolochiae 60 parts, Radix Arnebiae (Radix Lithospermi) 60 parts, Fructus Psoraleae 60 parts, Rhizoma Polygonati 90 parts, the Folium Ligustri Lucidi 80 parts, fish
Raw meat grass 60 parts, Fructus Aurantii 50 parts, Semen Torreyae 50 parts.
4. treat the Chinese medicine preparation of colpitis mycotica as claimed in claim 2, it is characterised in that it is by following weight proportion
Crude drug composition: Cortex Dictamni 140 parts, Radix Cucubali 160 parts, Herba Scutellariae Barbatae 110 parts, the Fructus Kochiae 90 parts, Herba Patriniae 90 parts, Cortex Hibisci
130 parts, Rhizoma Picrorhizae 160 parts, Radix Semiaquilegiae 110 parts, Herba Hedyotidis Diffusae 110 parts, root of Indian kalimeris herb 100 parts, Caulis Sargentodoxae 80 parts, Herba Lycopi 90 parts,
Folium Hibisci Mutabilis 90 parts, Cacumen Securinegae Suffruticosae 50 parts, Herba Aristolochiae 70 parts, Radix Arnebiae (Radix Lithospermi) 50 parts, Fructus Psoraleae 70 parts, Rhizoma Polygonati 100 parts, the Folium Ligustri Lucidi 70 parts,
Herba Houttuyniae 70 parts, Fructus Aurantii 60 parts, Semen Torreyae 60 parts.
5. treat the Chinese medicine preparation of colpitis mycotica as claimed in claim 2, it is characterised in that it is by following weight proportion
Crude drug composition: Cortex Dictamni 160 parts, Radix Cucubali 140 parts, Herba Scutellariae Barbatae 90 parts, the Fructus Kochiae 110 parts, Herba Patriniae 110 parts, Hibiscus syriacus L.
Skin 110 parts, Rhizoma Picrorhizae 140 parts, Radix Semiaquilegiae 90 parts, Herba Hedyotidis Diffusae 90 parts, root of Indian kalimeris herb 80 parts, Caulis Sargentodoxae 100 parts, Herba Lycopi 70 parts,
Folium Hibisci Mutabilis 70 parts, Cacumen Securinegae Suffruticosae 70 parts, Herba Aristolochiae 50 parts, Radix Arnebiae (Radix Lithospermi) 70 parts, Fructus Psoraleae 50 parts, Rhizoma Polygonati 80 parts, the Folium Ligustri Lucidi 90 parts, fish
Raw meat grass 50 parts, Fructus Aurantii 40 parts, Semen Torreyae 40 parts.
6. the Chinese medicine preparation as described in arbitrary in Claims 1 to 5, it is characterised in that described Chinese medicine preparation dosage form is lotion, solidifying
Colloid, suppository etc..
7. Chinese medicine preparation as claimed in claim 6, it is characterised in that described Chinese medicine preparation dosage form is preferably lotion.
8. the preparation method of Chinese medicine preparation as described in Claims 1 to 5 is arbitrary, it is characterised in that it is by following processing step
Make:
Take Cortex Dictamni, Radix Cucubali, Herba Scutellariae Barbatae, the Fructus Kochiae, Herba Patriniae, Cortex Hibisci, Rhizoma Picrorhizae, Radix Semiaquilegiae, Herba Hedyotidis Diffusae, Herba Kalimeridis
Root, Caulis Sargentodoxae, Herba Lycopi, Folium Hibisci Mutabilis, Cacumen Securinegae Suffruticosae, Herba Aristolochiae, Radix Arnebiae (Radix Lithospermi), Fructus Psoraleae, Rhizoma Polygonati, the Folium Ligustri Lucidi, Herba Houttuyniae, Fructus Aurantii, Semen Torreyae,
Boiling secondary, adds the water of medical material weight 8～12 times amount for the first time, and decocting time is 0.5～2 hour, and second time adds
The water of medical material weight 7～9 times amount, decocting time is 0.5～2 hour, merges twice decocting liquid, filters, and filtrate is condensed into the closeest
Degree is the clear paste of 1.05～1.10, stirs, and stands 8～16 hours, filter, centrifugal treating, centrifugal speed 2000～
4000rpm, centrifugation time 10～20min, take supernatant, subpackage, sterilizing, to obtain final product.
9. the preparation method of Chinese medicine preparation as claimed in claim 8, it is characterised in that it is made up of following processing step:
Take Cortex Dictamni, Radix Cucubali, Herba Scutellariae Barbatae, the Fructus Kochiae, Herba Patriniae, Cortex Hibisci, Rhizoma Picrorhizae, Radix Semiaquilegiae, Herba Hedyotidis Diffusae, Herba Kalimeridis
Root, Caulis Sargentodoxae, Herba Lycopi, Folium Hibisci Mutabilis, Cacumen Securinegae Suffruticosae, Herba Aristolochiae, Radix Arnebiae (Radix Lithospermi), Fructus Psoraleae, Rhizoma Polygonati, the Folium Ligustri Lucidi, Herba Houttuyniae, Fructus Aurantii, Semen Torreyae,
Boiling secondary, adds the water of medical material weight 10 times amount for the first time, and decocting time is 1 hour, and second time adds medical material weight 8
The water of times amount, decocting time is 1 hour, merges twice decocting liquid, filter, filtrate be condensed into relative density be 1.05～1.10 clear
Cream, stirs, and stands 12 hours, filters, centrifugal treating, centrifugal speed 3000rpm, centrifugation time 15min, takes supernatant
Liquid, subpackage, sterilizing, to obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610646727.6A CN106266557A (en) | 2016-08-09 | 2016-08-09 | A kind of Chinese medicine preparation treating colpitis mycotica |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610646727.6A CN106266557A (en) | 2016-08-09 | 2016-08-09 | A kind of Chinese medicine preparation treating colpitis mycotica |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106266557A true CN106266557A (en) | 2017-01-04 |
Family
ID=57666831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610646727.6A Withdrawn CN106266557A (en) | 2016-08-09 | 2016-08-09 | A kind of Chinese medicine preparation treating colpitis mycotica |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106266557A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107929490A (en) * | 2017-12-15 | 2018-04-20 | 唐东 | A kind of Chinese medicinal lotion its preparation method for treating gynecology colpitis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1473606A (en) * | 2003-08-08 | 2004-02-11 | 贵州浩诚药业有限公司 | Baizhi dehumidizer made from gloden cyllress and cape jasmine etc. Chinese herbal medicines |
| CN101612343A (en) * | 2009-07-28 | 2009-12-30 | 杭州普瑞美克生物科技有限公司 | A kind of washing liquid for the treatment of female vagina inflammation |
-
2016
- 2016-08-09 CN CN201610646727.6A patent/CN106266557A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1473606A (en) * | 2003-08-08 | 2004-02-11 | 贵州浩诚药业有限公司 | Baizhi dehumidizer made from gloden cyllress and cape jasmine etc. Chinese herbal medicines |
| CN101612343A (en) * | 2009-07-28 | 2009-12-30 | 杭州普瑞美克生物科技有限公司 | A kind of washing liquid for the treatment of female vagina inflammation |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107929490A (en) * | 2017-12-15 | 2018-04-20 | 唐东 | A kind of Chinese medicinal lotion its preparation method for treating gynecology colpitis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101804166B (en) | Traditional Chinese medicine composition for treating dermatitis and eczema of infants | |
| CN101612343A (en) | A kind of washing liquid for the treatment of female vagina inflammation | |
| CN100434107C (en) | Acne clearing decoction | |
| CN101361937A (en) | Medicinal pad with antibiosis, itching-relieving, wind-dispelling and dampness-eliminating function | |
| CN101869626A (en) | Chinese medicinal compound preparation private care liquid, and preparation and application thereof | |
| CN103800772A (en) | Gynecological external lotion for preventing and treating vagina inflammatory diseases and preparation method thereof | |
| CN103494958B (en) | Traditional Chinese medicine lotion for treating gynecological inflammations as well as preparation method thereof | |
| CN102000194B (en) | Traditional Chinese medicine composition for treating tympanitis and preparation method thereof | |
| CN104436131A (en) | Pharmaceutical composition used for treating swine dysentery and preparation method of pharamceutical composition | |
| CN100369618C (en) | Application of Chinese medicinal composition in preparation of medicine for treating gynecological inflammation | |
| CN101732614B (en) | Chinese medicament for treating urinary tract infection | |
| CN101391065B (en) | Compound momordica seed pepper soup for treating urgent chronic pelvic inflammatory disease | |
| CN105816594A (en) | Medicinal composition for treating acne as well as preparation method and application of medicinal composition | |
| CN102526639B (en) | Chinese medicinal composition for treating hyperlipidemia and preparation method thereof | |
| CN106266557A (en) | A kind of Chinese medicine preparation treating colpitis mycotica | |
| CN105012818A (en) | Composition for treating gynecological inflammation and preparation and preparation method thereof | |
| CN106109908A (en) | A kind of mongolian medicine compositions treating sheep babesiasis | |
| CN105709101A (en) | Traditional Chinese medicine preparation for treating blepharitis ciliaris and preparation method thereof | |
| CN1970020B (en) | A pharmaceutical composition, preparation process and application thereof | |
| CN105641265A (en) | Aloe combination drug used for treating acne, preparation thereof and application thereof | |
| CN107951972A (en) | Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing and preparation method thereof | |
| CN102198191B (en) | Quick acting medicine for treating prostate and urinary system infections, and production process thereof | |
| CN105381177A (en) | External use traditional Chinese medicine for treating sweet stains | |
| CN105395633A (en) | Liniment for external application for suppurative otitis media and preparing method thereof | |
| CN104840823A (en) | Traditional Chinese medicine preparation for treating otitis media and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170104 |