CN104840823A - Traditional Chinese medicine preparation for treating otitis media and preparation method - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating otitis media and a preparation method. The traditional Chinese medicine preparation is prepared from the following main raw materials in parts by weight: 12-16 parts of radix bupleuri, 10-15 parts of all-grass of broadleaf ainslaea, 11-16 parts of wild chrysanthemum flower, 9-13 parts of rhizoma acori graminei, 8-14 parts of seeds of Chinese waxgourd, 10-17 parts of trichosanthes kirilowii, 11-15 parts of selfheal, 9-17 parts of dandelion, 8-16 parts of saxifrage, 10-14 parts of common andrographis herb, 9-16 parts of coix seeds, 11-14 parts of perilla leaves, 8-13 parts of radix semiaquilegiae and 9-12 parts of radix angelicae. The traditional Chinese medicine preparation is remarkable in curative effect, safe, and free of side effect, cannot cause reliance, and treats both symptoms and root causes of otitis media; and by using the traditional Chinese medicine preparation, the otitis media is difficult to recur.

Description

A kind of Chinese medicine preparation and method for making for the treatment of otitis media

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine preparation and method for making for the treatment of otitis media.

Background technology

Otitis media is equivalent to the categories such as " bulge of the ear ", " deafness " of Chinese medicine.Be because affection due to external wind and heat or wind and cold and dampness-heat in the liver and gallbladder, cause ear key meridians and block, QI and blood is detained and falls ill; Or because suffering from a deficiency of the kidney, damp-phlegm resistance lung, stagnation of dampness due to deficiency of the spleen and stagnation of QI-blood caused by.Clinical common disease type has: qi-deficiency of spleen and stomach: bulge of the ear vexed as cotton stopper it, auditory dysesthesia increases the weight of gradually, and in ear, the cicada cried, overworks and can make it to increase the weight of, and otopiesis is obvious, and lose normal gloss, also show pale white complexion, tongue fur is light, and pulse condition is slow thin.Liver-kidney yin deficiency: in ear is vexed slightly swollen, auditory dysesthesia is obvious, and in ear, the cicada cried goinges on day and night without stopping, and night is more so, tympanic membrane shrinkage, poor, or sees canescence deposition speckle, can with soreness of waist and knee, and dizziness and blurred vision, red tongue tongue is few, thready and weak pulse.Kidney yang deficiency: auditory dysesthesia, tinnitus, with soreness of waist cold extremities, face whitens, and health is easily tired, frequent micturition, pale tongue with thin fur, thready and weak pulse.Lung meridian wind-heat type: in ear feeling of distension and oppression hypodynia, tinnitus is as hearsay sound, and auditory dysesthesia, listens oneself voice comparatively sound, but unintelligible, and normal happiness presses ear with hands, and tympanum is slightly congested, slightly caves in, with nasal obstruction, watery nasal discharge, the micro-Huang of tongue, thin lingual fur, floating and rapid pulse.Ascites of liver meridian damp-heat type: in ear closes vexed, auditory dysesthesia, tinnitus, tympanum is outer grand, heavy with head body, white and greasy fur, rolling pulse.

Treatment: 1. active treatment upper respiratory tract focus disease.As chronic sinusitis, chronic tonsillitis.2. Drug therapy: simple type based on local application, available aqueous topical antibiotics or antibiotic and steroid hormones mixed liquor, as 0.25% chloromycetin solution, chloromycetin cortisone liquid, ofloxacin ear drops etc., treatment otitis media and otitis externa etc.3. local application's points for attention: before (1) medication: pus in first washing external auditory meatus and tympanum, available 3% hydrogen peroxide or the cleaning of boric acid water, rear swab is wiped clean or is exhausted pus with suction pump and can drip medicine.(2), when pus amount is many: with water preparation, when amount is few, boric acid alcohol can be used.4. big perforation of tympanic membrane affects audition, feasible tympanic membrane repairing or tympanoplasty.

Application publication number CN 104257814 A(application number 201410470976.5) Chinese patent literature disclose a kind of medicine for the treatment of otitis media, bag Herba Hedyotidis Diffusae 2-6g, draw together Scolopendra one, Periostracum Serpentis 3-8g, Faeces Vespertilionis 2-6g, Fructus Psoraleae 10-20g, Thallus Laminariae (Thallus Eckloniae) 3-8g, cotton seed 5-10g, Herba Epimedii 4-8g, Flos Lonicerae 10-20g, Fructus Forsythiae 5-12g and glycerol 10-24g.Application publication number CN 103191213 A(application number 201310154572.0) Chinese patent literature disclose a kind of Chinese medicine for the treatment of otitis media.The Chinese medicine of this treatment otitis media for raw material, is mixed and made into powder according to certain weight proportion with wine Scorpio, stir-baked SQUAMA MANITIS, prepared PERIOSTRACUM SERPENIS with vino, dried Alumen, Bombyx bombycis, Endoconcha Sepiae, Borax, Rhizoma Coptidis, Indigo Naturalis, Os Draconis and MEIHUA BINGPIAN.Application publication number CN 103479823 A(application number 201310445950.0) Chinese patent literature disclose a kind of Chinese medicine preparation for the treatment of otitis media, the raw material of its effective ingredient consists of: Folium Malloti Apeltae, Radix Berberidis Amurensis, Calendula officinalis, Radix Seu Herba Physochlainae Physaloidis, Herba Pothi Chinensis, Herba Hydrocotyles, Folium Citri grandis, Radix abutili indici, Borax, Asteriscus Pseudosciaenae, Herba Andrographis, Flos Granati, Concha, Armillaria mella tabescens (Scop.ex Fr.) Sing., Radix Rubi sumatrani and Herba Agerati Conyzoidis.

At present, for the treatment of otitis media, based on local application: available aqueous topical antibiotics or antibiotic and steroid hormones mixed liquor, though the Drug therapy energy respite state of an illness, owing to there is obvious untoward reaction, the treatment curative effect of doctor trained in Western medicine is low, side effect is large, dependency is strong, once drug withdrawal, easily recurs, and is not the way of radical cure.Tympanic membrane repairing is a kind of traditional therapy being applicable to caries type otitis media, Cholesteatomatous Tympanitis, generally that pathological changes three in mastoid process, tympanic antrum and tympanum is communicated with external auditory meatus, form the cavity of a protective epithelium, remove mastoid process, tympanic antrum, tympanum and ostium tympanicum tubae auditivae pathological tissues to reach, stop suppurating, obtaining the object of dry ear.The method cannot reach the object removing focus, easily recurs.

Summary of the invention

For the deficiencies in the prior art, the object of this invention is to provide a kind of Chinese medicine preparation and method for making for the treatment of otitis media.The present invention is evident in efficacy, safely, has no side effect, and can not produce dependency, treating both the principal and secondary aspects of a disease, not easily recur.

Technical scheme of the present invention is:

Treat a Chinese medicine preparation for otitis media, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Bupleuri 12-16, Herba Ainsliaeae Latifoliae 10-15, Flos Chrysanthemi Indici 11-16, Rhizoma Acori Graminei 9-13, Semen Benincasae 8-14, Fructus Trichosanthis 10-17, Spica Prunellae 11-15, Herba Taraxaci 9-17, Chrysosplenium Hydrocotylifolium Levl. Et Van. 8-16, Herba Andrographis 10-14, Semen Coicis 9-16, Folium Perillae 11-14, Radix Semiaquilegiae 8-13, Radix Angelicae Dahuricae 9-12.

Treat a Chinese medicine preparation for otitis media, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Bupleuri 13-15, Herba Ainsliaeae Latifoliae 11-14, Flos Chrysanthemi Indici 12-15, Rhizoma Acori Graminei 10-12, Semen Benincasae 10-13, Fructus Trichosanthis 12-15, Spica Prunellae 12-14, Herba Taraxaci 11-14, Chrysosplenium Hydrocotylifolium Levl. Et Van. 10-13, Herba Andrographis 11-13, Semen Coicis 11-14, Folium Perillae 12-13, Radix Semiaquilegiae 9-12, Radix Angelicae Dahuricae 10-11.

Treat a Chinese medicine preparation for otitis media, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Bupleuri 14, Herba Ainsliaeae Latifoliae 13, Flos Chrysanthemi Indici 14, Rhizoma Acori Graminei 11, Semen Benincasae 12, Fructus Trichosanthis 14, Spica Prunellae 13, Herba Taraxaci 12, Chrysosplenium Hydrocotylifolium Levl. Et Van. 12, Herba Andrographis 12, Semen Coicis 13, Folium Perillae 12.5, Radix Semiaquilegiae 11, the Radix Angelicae Dahuricae 10.5.

Present invention also offers the preparation method Chinese medicine preparation of aforementioned therapies otitis media being made pharmaceutically acceptable powder, pill, granule and tablet.

The preparation method of described powder is:

(1) Flos Chrysanthemi Indici being put into temperature is in the baking oven of 50 DEG C, and dry 5-7 hour (preferably dry 6 hours), take out, cool, be ground into fine powder, cross No. seven sieves;

(2) get Semen Coicis, put in pot, at the temperature of 115-125 DEG C, fry (preferably frying at the temperature of 120 DEG C), fry 16-28 minute (preferably frying 22 minutes), take out, cool, be ground into fine powder, cross No. seven sieves;

(3) all the other the 12 taste crude drug except Flos Chrysanthemi Indici and Semen Coicis are ground to the powder altogether, cross No. seven sieves;

(4) step (1), step (2) and step (3) gained are mixed, in the baking oven of 55 DEG C, dry 4-8 hour (preferably in the baking oven of 55 DEG C dry 5 hours), often to wrap 4g subpackage, encapsulates and get final product.

The preparation method of described pill is:

(1) Flos Chrysanthemi Indici being put into temperature is in the baking oven of 50 DEG C, and dry 5-7 hour (preferably dry 6 hours), take out, cool, be ground into fine powder, cross No. five sieves;

(2) get Semen Coicis, put in pot, at the temperature of 115-125 DEG C (preferably at the temperature of 120 DEG C), fry 16-28 minute (preferably frying 22 minutes), take out, cool, be ground into fine powder, cross No. five sieves;

(3) all the other the 12 taste crude drug except Flos Chrysanthemi Indici and Semen Coicis are ground to the powder altogether, cross No. five sieves;

(4) step (1), step (2) and step (3) gained are mixed, with the general ball of vinegar, make the pill of the heavy 0.05g of every ball, dry, to obtain final product.

The preparation method of described granule is:

(1) Flos Chrysanthemi Indici being put into temperature is in the baking oven of 50 DEG C, and dry 5-7 hour (preferably dry 6 hours), take out, cool, be ground into fine powder, cross No. five sieves;

(2) get Semen Coicis, put in pot, at the temperature of 115-125 DEG C (preferably at the temperature of 120 DEG C), fry 16-28 minute (preferably frying 22 minutes), take out, cool, be ground into fine powder, cross No. five sieves;

(3) all the other the 12 taste crude drug except Flos Chrysanthemi Indici and Semen Coicis are ground to the powder altogether, cross No. five sieves;

(4) step (1), step (2) and step (3) gained are mixed, add dextrin, the weight of dextrin is step (1), the weight of the preferred dextrin of 1/10-1/5(of step (2) and step (3) gained gross weight is 1/8 of step (1), step (2) and step (3) gained gross weight), mixing, add 95% ethanol and regulate viscosity, agglomerating to hold, namely faling apart of pine, hold imperceptible viscosity for degree, mixing, crosses 20 mesh sieves and granulates, 50 DEG C of dryings 12 hours, with 10 mesh sieve granulate, to obtain final product.

The preparation method of described tablet is:

(1) Flos Chrysanthemi Indici being put into temperature is in the baking oven of 50 DEG C, and dry 5-7 hour (preferably dry 6 hours), take out, cool, be ground into fine powder, cross No. five sieves;

(2) get Semen Coicis, put in pot, at the temperature of 115-125 DEG C (preferably at the temperature of 120 DEG C), fry 16-28 minute (preferably frying 22 minutes), take out, cool, be ground into fine powder, cross No. five sieves;

(3) all the other the 12 taste crude drug except Flos Chrysanthemi Indici and Semen Coicis are ground to the powder altogether, cross No. five sieves;

(4) step (1), step (2) and step (3) gained are mixed, add dextrin, the weight of dextrin is step (1), the weight of the preferred dextrin of 1/10-1/5(of step (2) and step (3) gained gross weight is 1/8 of step (1), step (2) and step (3) gained gross weight), mixing, add 95% ethanol and regulate viscosity, agglomerating to hold, namely faling apart of pine, hold imperceptible viscosity for degree, mixing, cross 20 mesh sieves and granulate, 50 DEG C of dryings 12 hours, tabletting, the heavy 0.4g of every sheet, to obtain final product.

Chinese medicine preparation scientific formula provided by the invention, the preparation method of various dosage form is simple.In addition, excellent results of the present invention also shows:

1, evident in efficacy, can not dependency be produced;

, have no side effect 2, safely;

3, treating both the principal and secondary aspects of a disease, not easily recurs;

4, without rare valuable drug, medicine source is easy to get, and cheap.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.

embodiment 1treat a Chinese medicine preparation for otitis media, the primary raw material medicine getting following weight parts is prepared from (every part is 400g): Radix Bupleuri 12 parts, Herba Ainsliaeae Latifoliae 10 parts, Flos Chrysanthemi Indici 11 parts, Rhizoma Acori Graminei 9 parts, Semen Benincasae 8 parts, Fructus Trichosanthis 10 parts, Spica Prunellae 11 parts, Herba Taraxaci 9 parts, Chrysosplenium Hydrocotylifolium Levl. Et Van. 8 parts, Herba Andrographis 10 parts, Semen Coicis 9 parts, Folium Perillae 11 parts, Radix Semiaquilegiae 8 parts, the Radix Angelicae Dahuricae 9 parts.

The preparation method of the Chinese medicine preparation powder of above-mentioned treatment otitis media is:

(1) Flos Chrysanthemi Indici being put into temperature is in the baking oven of 50 DEG C, dry 5 hours, takes out, cools, be ground into fine powder, crosses No. seven sieves;

(2) get Semen Coicis, put in pot, fry at the temperature of 115 DEG C, fry 16 minutes, take out, cool, be ground into fine powder, cross No. seven sieves;

(3) all the other the 12 taste crude drug except Flos Chrysanthemi Indici and Semen Coicis are ground to the powder altogether, cross No. seven sieves;

(4) step (1), step (2) and step (3) gained are mixed, in the baking oven of 55 DEG C, drying 4 hours, often to wrap 4g subpackage, encapsulates and get final product.

The using method of the Chinese medicine preparation of gained treatment otitis media of the present invention is: oral, one day twice, and each bag, boiled water is taken after mixing it with water.

embodiment 2treat a Chinese medicine preparation for otitis media, the primary raw material medicine getting following weight parts is prepared from (every part is 400g): Radix Bupleuri 16 parts, Herba Ainsliaeae Latifoliae 15 parts, Flos Chrysanthemi Indici 16 parts, Rhizoma Acori Graminei 13 parts, Semen Benincasae 14 parts, Fructus Trichosanthis 17 parts, Spica Prunellae 15 parts, Herba Taraxaci 17 parts, Chrysosplenium Hydrocotylifolium Levl. Et Van. 16 parts, Herba Andrographis 14 parts, Semen Coicis 16 parts, Folium Perillae 14 parts, Radix Semiaquilegiae 13 parts, the Radix Angelicae Dahuricae 12 parts.

The preparation method of the Chinese medicine preparation pill of above-mentioned treatment otitis media is:

(1) Flos Chrysanthemi Indici being put into temperature is in the baking oven of 50 DEG C, dry 6 hours, takes out, cools, be ground into fine powder, crosses No. five sieves;

(2) get Semen Coicis, put in pot, fry at the temperature of 120 DEG C, fry 22 minutes, take out, cool, be ground into fine powder, cross No. five sieves;

(3) all the other the 12 taste crude drug except Flos Chrysanthemi Indici and Semen Coicis are ground to the powder altogether, cross No. five sieves;

(4) step (1), step (2) and step (3) gained are mixed, with the general ball of vinegar, make the pill of the heavy 0.05g of every ball, dry, to obtain final product.

model case one:king XX, man, 44 years old.Main suit: otalgia, more than the liquid March of suppurating.Patient is before three months, and the serious otalgia of persistence, flows out the pus of Lycoperdon polymorphum Vitt or yellow frequently, companion's cephalagia, and gradually occur revolving dizzy, tinnitus, inappetence, without nausea and vomiting.Once by Drug therapys such as ofloxacin ear drops, without being clearly better.On July 13rd, 2010 examines.Examine and see that patient's ears are wide without deformity, visible pus in right ear canal, yellow-white, visible bean dregs block sample thing, without the blood streak, frowziness, after cleaning, the swelling of a visible external auditory meatus ancient piece of jade, round, flat and with a hole in its centre, tympanum is invisible, left external auditory canal is dry, clean, and tympanum is without congested and perforation, and ears mastoid process is without tenderness.Other positions are without special discovery.Temporal bone CT shows right side sclerotic mastoid, interior visible soft tissue shadow, bone destruction around, and auditory ossicles is not obvious, and right tympanic antrum expands, left side middle ear and mastoid process no abnormality seen.Bilateral internal ear and lnner stripe no abnormality seen.Have a medical check-up: T:37.1 DEG C, P:74 beat/min, R:20 beat/min, Bp:125/77mmHg.Be diagnosed as otitis media.Take the Chinese medicine preparation pill of the present embodiment gained treatment otitis media, three times on the one, each 10 balls, warm water takes.Take 5 days, only suppurate, otalgia obviously alleviates.Continue to take 5 days, all diseases disappear, and cure.Follow up a case by regular visits to without recurrence.

embodiment 3treat a Chinese medicine preparation for otitis media, the primary raw material medicine getting following weight parts is prepared from (every part is 400g): Radix Bupleuri 13 parts, Herba Ainsliaeae Latifoliae 11 parts, Flos Chrysanthemi Indici 12 parts, Rhizoma Acori Graminei 10 parts, Semen Benincasae 10 parts, Fructus Trichosanthis 12 parts, Spica Prunellae 12 parts, Herba Taraxaci 11 parts, Chrysosplenium Hydrocotylifolium Levl. Et Van. 10 parts, Herba Andrographis 11 parts, Semen Coicis 11 parts, Folium Perillae 12 parts, Radix Semiaquilegiae 9 parts, the Radix Angelicae Dahuricae 10 parts.

The preparation method of the Chinese medicine preparation granule of above-mentioned treatment otitis media is:

(1) Flos Chrysanthemi Indici being put into temperature is in the baking oven of 50 DEG C, dry 6 hours, takes out, cools, be ground into fine powder, crosses No. five sieves;

(2) get Semen Coicis, put in pot, fry at the temperature of 120 DEG C, fry 22 minutes, take out, cool, be ground into fine powder, cross No. five sieves;

(3) all the other the 12 taste crude drug except Flos Chrysanthemi Indici and Semen Coicis are ground to the powder altogether, cross No. five sieves;

(4) step (1), step (2) and step (3) gained are mixed, add dextrin, the weight of dextrin is 1/8 of step (1), step (2) and step (3) gained gross weight, mixing, add 95% ethanol and regulate viscosity, agglomerating to hold, namely faling apart of pine, hold imperceptible viscosity for degree, mixing, crosses 20 mesh sieves and granulates, 50 DEG C of dryings 12 hours, with 10 mesh sieve granulate, to obtain final product.

model case two:yuan XX, female, 52 years old.Main suit: otitis media more than 6 years.Before 6 years, there is left ear otalgia in patient, suppurates, and pus is yellow liquid.Inspection is diagnosed as otitis media, many hospitalize poor effect in locality.On August 22nd, 2011 examines.Look into T:36.9 DEG C, R:28 beat/min, P:82 beat/min, BP:115/73mmHg.Left side external auditory meatus has yellow purulent secretion, auricle tractive pain.More than show no obvious abnormalities.Be diagnosed as otitis media.Take the Chinese medicine preparation granule of the present embodiment gained treatment otitis media, one day twice, each 12g, warm water took.Take one week, otalgia obviously alleviates, and only suppurates.Continue to take one week, all disease knowing disappear, recovery from illness.Follow up a case by regular visits to without recurrence.

embodiment 4treat a Chinese medicine preparation for otitis media, the primary raw material medicine getting following weight parts is prepared from (every part is 400g): Radix Bupleuri 15 parts, Herba Ainsliaeae Latifoliae 14 parts, Flos Chrysanthemi Indici 15 parts, Rhizoma Acori Graminei 12 parts, Semen Benincasae 13 parts, Fructus Trichosanthis 15 parts, Spica Prunellae 14 parts, Herba Taraxaci 14 parts, Chrysosplenium Hydrocotylifolium Levl. Et Van. 13 parts, Herba Andrographis 13 parts, Semen Coicis 14 parts, Folium Perillae 13 parts, Radix Semiaquilegiae 12 parts, the Radix Angelicae Dahuricae 11 parts.

The preparation method of the Chinese medicine preparation tablet of above-mentioned treatment otitis media is:

(1) Flos Chrysanthemi Indici being put into temperature is in the baking oven of 50 DEG C, dry 6 hours, takes out, cools, be ground into fine powder, crosses No. five sieves;

(2) get Semen Coicis, put in pot, fry at the temperature of 120 DEG C, fry 22 minutes, take out, cool, be ground into fine powder, cross No. five sieves;

(3) all the other the 12 taste crude drug except Flos Chrysanthemi Indici and Semen Coicis are ground to the powder altogether, cross No. five sieves;

(4) step (1), step (2) and step (3) gained are mixed, add dextrin, the weight of dextrin is 1/8 of step (1), step (2) and step (3) gained gross weight, mixing, adds 95% ethanol and regulates viscosity, agglomerating to hold, namely faling apart of pine, hold imperceptible viscosity for degree, mixing, cross 20 mesh sieves and granulate, 50 DEG C of dryings 12 hours, tabletting, the heavy 0.4g of every sheet, to obtain final product.

model case three:open XX, female, 25 years old.Main suit: tinnitus, auditory dysesthesia, bulge of the ear be vexed, block sense more than 2 years.Before 2 years, patient occurs that in ear, the cicada cried, bulge of the ear vexed as cotton stopper it, auditory dysesthesia symptom, once arrived various big hospital treatment, be not improved.Introduce through friend, patient examined on July 11st, 2010.Patient tinnitus, auditory dysesthesia, bulge of the ear be vexed, block sense, and otopiesis is obvious, and lose normal gloss, tongue fur is light, and pulse condition is slow thin.Be diagnosed as otitis media.Take the Chinese medicine preparation tablet of the present embodiment gained treatment otitis media, one day twice, each 2, warm water took.Take 5 days, above-mentioned symptom alleviates.Continue to take 1 week, all diseases disappear, and cure.Follow up a case by regular visits to and have no recurrence.

embodiment 5treat a Chinese medicine preparation for otitis media, the primary raw material medicine getting following weight parts is prepared from (every part is 400g): Radix Bupleuri 14 parts, Herba Ainsliaeae Latifoliae 13 parts, Flos Chrysanthemi Indici 14 parts, Rhizoma Acori Graminei 11 parts, Semen Benincasae 12 parts, Fructus Trichosanthis 14 parts, Spica Prunellae 13 parts, Herba Taraxaci 12 parts, Chrysosplenium Hydrocotylifolium Levl. Et Van. 12 parts, Herba Andrographis 12 parts, Semen Coicis 13 parts, Folium Perillae 12.5 parts, Radix Semiaquilegiae 11 parts, the Radix Angelicae Dahuricae 10.5 parts.

The preparation method of the Chinese medicine preparation powder of above-mentioned treatment otitis media is:

(1) Flos Chrysanthemi Indici being put into temperature is in the baking oven of 50 DEG C, dry 6 hours, takes out, cools, be ground into fine powder, crosses No. seven sieves;

(2) get Semen Coicis, put in pot, fry at the temperature of 120 DEG C, fry 22 minutes, take out, cool, be ground into fine powder, cross No. seven sieves;

(3) all the other the 12 taste crude drug except Flos Chrysanthemi Indici and Semen Coicis are ground to the powder altogether, cross No. seven sieves;

(4) step (1), step (2) and step (3) gained are mixed, in the baking oven of 55 DEG C, drying 5 hours, often to wrap 4g subpackage, encapsulates and get final product.

The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:

Radix Bupleuri: base is former: be the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..The property of medicine: bitter, is slightly cold.Return liver, gallbladder meridian.Function cures mainly: reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.

Herba Ainsliaeae Latifoliae: base is former: be the herb of the wide fringe Ainsliaea fragrans Champ. of feverfew.The property of medicine: acrid in the mouth; Micro-hardship; Warm in nature.Function cures mainly: expelling wind and cold, promoting blood circulation and detumescence.Main anemofrigid cold, headache, lumbago, intestinal fire, dysentery, traumatic injury congestive edema, traumatic hemorrhage, otitis media, mastitis.

Flos Chrysanthemi Indici: base is former: be the flower of feverfew Herba Dendranthematis indici and lavandulaleaf dendranthema herb.The property of medicine: bitter in the mouth; Pungent; Property is put down.Return lung, Liver Channel.Function cures mainly: heat-clearing and toxic substances removing, dispelling wind suppressing the hyperactive liver.Main furuncle, carbuncle, erysipelas, eczema, dermatitis, anemopyretic cold, laryngopharynx swelling and pain, hypertension.

Rhizoma Acori Graminei: base is former: be the rhizome of South, sky section phytobezoar Rhizoma Acori Graminei.The property of medicine: pungent, tepor, GUIXIN, liver, spleen channel.Function cures mainly: have one's ideas straightened out, and eliminating phlegm is regulated the flow of vital energy, and invigorates blood circulation, and loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.

Semen Benincasae: base is former: be the seed of cucurbitaceous plant Fructus Benincasae.The property of medicine: sweet in the mouth, cold nature.Return lung, large intestine channel.Function cures mainly: removing heat from the lung and dissipating phlegm, eliminating carbuncle evacuation of pus, dampness removing.Main phlegm-heat cough, lung abscess, acute appendicitis, nebulousurine, leukorrhagia, beriberi, edema, stranguria.

Fructus Trichosanthis: another name Fructus Trichosanthis, Gua Lou, medicine melon is the fruit of Cucurbitaceae Trichosanthes Fructus Trichosanthis and trichosanthes rosthornii Harms.The property of medicine: sweet, micro-hardship, cold.Return lung, stomach, large intestine channel.Function cures mainly: removing heat-phlegm, and relieving stuffiness of the chest by dispersing aggregation of pathogens moisturizes laxation.Cure mainly cough due to lung-heat, the thoracic obstruction, blocked-up chest, quench one's thirst, constipation, carbuncle sore tumefacting virus.

Spica Prunellae: base is former: be the dry fruit ear of labiate Spica Prunellae.The property of medicine: pungent, bitter, cold.Return liver, gallbladder meridian.Function cures mainly: relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache, thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.

Herba Taraxaci: base is former: for feverfew Herba Taraxaci, alkali ground Herba Taraxaci, Herba Taraxaci ohwiani, different luxuriant Herba Taraxaci, Taraxacum asiatica Dahlst, Taraxacum erythropodium Kifag etc. belong to the herb of various plants together.The property of medicine: bitter in the mouth, sweet, cold in nature.Return liver, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.Main acute mastitis, lung abscess, acute appendicitis, mumps, furuncle carbuncle toxin, conjunctival congestion and swelling pain, cold, fever, cough, laryngopharynx swelling and pain, stomach-fire, enteritis, dysentery, hepatitis, gallbladder frightens inflammation, urinary tract infection, snake bite and insect sting.

Chrysosplenium Hydrocotylifolium Levl. Et Van.: base is former: be the herb of saxifragaceae plant ovum lobus cardiacus Herba Saxifragae.The property of medicine: micro-hardship, pungent; Cold; Mild toxicity.GUIXIN, lung meridian.Function cures mainly: heat-clearing and toxic substances removing, promoting blood circulation and hemostasis.Djumah rash, high heat, cough, otitis media, bronchitis, spitting of blood, spits blood, skin allergy, menoxenia, parotitis, mastitis, innominate toxic swelling, venom, skin ulcer, eczema, burn and scald.

Herba Andrographis: base is former: be herb or the leaf of acanthaceous plant Herba Andrographis.The property of medicine: " Quanzhou book on Chinese herbal medicine ": " bitter in the mouth, cold in nature, nontoxic." " Quanzhou book on Chinese herbal medicine ": " enter the heart, lung two warp." function cures mainly: heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.Control acute bacillary dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, oropharynx swells and ache, furuncle carbuncle, burn due to hot liquid or fire, venom.

Semen Coicis: base is former: be the kernel of grass Semen Coicis.The property of medicine: sweet; Light; Be slightly cold.Return spleen, lung, kidney channel.Function cures mainly: dampness removing spleen invigorating, arthralgia relieving by relaxing muscles and tendons, clearing away heat and discharging pus.Main edema, beriberi, dribbling urination, damp-warm diseases, leukorrhagia of having loose bowels, rheumatic arthralgia, the contracture of muscle arteries and veins, lung abscess, acute appendicitis, verruca plana.

Folium Perillae: base is former: be the band branch tender leaf of Labiatae Perilla plant Folium Perillae.The property of medicine: pungent, temperature.Return lung meridian, spleen channel.Function cures mainly: expelling cold and relieving exterior syndrome, regulating the flow of QI to ease the stomach.For anemofrigid cold, headache, cough, distension and fullness of the chest and abdomen.

Radix Semiaquilegiae: base is former: be the tuber of ranunculaceae plant Radix Semiaquilegiae.The property of medicine: bitter in the mouth; Micro-hardship; Micro-pungent; Cold in nature; Mild toxicity.Return liver, spleen, urinary bladder channel.Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, relieving stranguria by diuresis.Main children's's heat is frightened, epilepsy, carbuncle, furuncle, acute mastitis, scrofula, skin itching sore, conjunctival congestion and swelling pain, pharyngalgia, snake bite and insect sting, pyretic stranguria, sand Stranguria.

The Radix Angelicae Dahuricae: base is former: be the dry root of the samphire Radix Angelicae Dahuricae or Radix angelicae dahuricae.The property of medicine: pungent, temperature.Return stomach, large intestine, lung meridian.Function cures mainly: loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.For headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.

test example 1the clinical practice of the Chinese medicine preparation (embodiment 5) of gained of the present invention treatment otitis media: in October, 2009 in December ,-2011, screen 280 routine otitis media patients in 4 hospitals, wherein male 145 example, women 135 example, age 20-65 year, 40.5 years old mean age, the course of disease 1 month-12 years.Be divided into two groups at random, experimental group and matched group (often organizing 140 examples).Between two groups of patients, the aspect such as sex, age, the state of an illness and course of disease compares, and no significant difference (P > 0.05), has comparability.

Therapeutic Method: experimental group uses gained of the present invention to treat the Chinese medicine preparation of otitis media, and using method is: oral, one day twice, each bag, boiled water is taken after mixing it with water, and within 7 days, is a course for the treatment of.Matched group uses the medicine (as Cefixime tablets, clindamycin phosphate injection, roxithromycin dispersing tablet etc.) of conventional therapy otitis media, within 7 days, is a course for the treatment of.Comparitive study is carried out after two groups of patients all treat two courses for the treatment of.

Curative effect situation criterion: cure: clinical symptom disappearance, tympanum recovery situation is good, auditory rehabilitation normal level; Effective: clinical symptom disappearance, tympanum reverts to normal condition, the pharyngotympanic tube person of keeping clear; Take a turn for the better: clinical symptoms makes moderate progress, eustachian tube function is improved obviously, and tympanum recovery extent is close with normal condition; Invalid: clinical symptoms without improvement, even aggravation.Total effectively comprising cures and effective, and result is as shown in table 1.

Table 1: the Chinese medicine preparation compliance test result of gained treatment otitis media of the present invention

Efficacy analysis: after two groups of cases treat two courses for the treatment of, experimental group cures 82 examples, effective 55 examples, and take a turn for the better 2 examples, invalid 1 example, total effective rate 97.86%; Matched group cures 35 examples, effective 67 examples, and take a turn for the better 22 examples, invalid 16 examples, total effective rate 72.86%.The cure rate of experimental group and total effective rate are apparently higher than matched group.Test shows, the clinical efficacy of experimental group is obviously better than matched group, and significant difference (P < 0.05), has statistical significance.

The present invention, through scientific compatibility, is primary raw material medicine with Radix Bupleuri, Herba Ainsliaeae Latifoliae, Flos Chrysanthemi Indici and Rhizoma Acori Graminei etc., makes the Chinese medicine preparation for the treatment of otitis media.In side, Radix Bupleuri reconciling superficies and interior, soothing the liver, yang invigorating.Herba Ainsliaeae Latifoliae expelling wind and cold, promoting blood circulation and detumescence.Flos Chrysanthemi Indici heat-clearing and toxic substances removing, dispelling wind suppressing the hyperactive liver.Rhizoma Acori Graminei is had one's ideas straightened out, eliminating phlegm, regulates the flow of vital energy, and invigorates blood circulation, and loose wind, dries.Semen Benincasae removing heat from the lung and dissipating phlegm, eliminating carbuncle evacuation of pus, dampness removing.Fructus Trichosanthis removing heat-phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturizes laxation.Spica Prunellae relieves inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.Herba Taraxaci heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.Chrysosplenium Hydrocotylifolium Levl. Et Van. heat-clearing and toxic substances removing, promoting blood circulation and hemostasis.Herba Andrographis heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.The spleen invigorating of Semen Coicis dampness removing, arthralgia relieving by relaxing muscles and tendons, clearing away heat and discharging pus.Folium Perillae expelling cold and relieving exterior syndrome, regulating the flow of QI to ease the stomach.Radix Semiaquilegiae heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, relieving stranguria by diuresis.Angelica dahurica powder wind dehumidifies, understand things pain-stopping, detumescence and apocenosis.Many medicines share, and mutually coordinate, have effect of dampness removing spleen invigorating, expelling wind and cold, understand things pain-stopping, vital energy regualting and blood circulation-promoting, eliminating carbuncle evacuation of pus, thoroughly can cure otitis media, evident in efficacy.

Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. treat a Chinese medicine preparation for otitis media, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Bupleuri 12-16, Herba Ainsliaeae Latifoliae 10-15, Flos Chrysanthemi Indici 11-16, Rhizoma Acori Graminei 9-13, Semen Benincasae 8-14, Fructus Trichosanthis 10-17, Spica Prunellae 11-15, Herba Taraxaci 9-17, Chrysosplenium Hydrocotylifolium Levl. Et Van. 8-16, Herba Andrographis 10-14, Semen Coicis 9-16, Folium Perillae 11-14, Radix Semiaquilegiae 8-13, Radix Angelicae Dahuricae 9-12.

2. the Chinese medicine preparation for the treatment of otitis media as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Bupleuri 13-15, Herba Ainsliaeae Latifoliae 11-14, Flos Chrysanthemi Indici 12-15, Rhizoma Acori Graminei 10-12, Semen Benincasae 10-13, Fructus Trichosanthis 12-15, Spica Prunellae 12-14, Herba Taraxaci 11-14, Chrysosplenium Hydrocotylifolium Levl. Et Van. 10-13, Herba Andrographis 11-13, Semen Coicis 11-14, Folium Perillae 12-13, Radix Semiaquilegiae 9-12, Radix Angelicae Dahuricae 10-11.

3. the Chinese medicine preparation for the treatment of otitis media as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Bupleuri 14, Herba Ainsliaeae Latifoliae 13, Flos Chrysanthemi Indici 14, Rhizoma Acori Graminei 11, Semen Benincasae 12, Fructus Trichosanthis 14, Spica Prunellae 13, Herba Taraxaci 12, Chrysosplenium Hydrocotylifolium Levl. Et Van. 12, Herba Andrographis 12, Semen Coicis 13, Folium Perillae 12.5, Radix Semiaquilegiae 11, the Radix Angelicae Dahuricae 10.5.

4. the Chinese medicine preparation of the treatment otitis media as described in as arbitrary in claims 1 to 3, it is characterized in that, the Chinese medicine preparation of this treatment otitis media is made pharmaceutically acceptable powder, and the preparation method of described powder is:

(1) Flos Chrysanthemi Indici being put into temperature is in the baking oven of 50 DEG C, dry 5-7 hour, takes out, cools, be ground into fine powder, crosses No. seven sieves;

(2) get Semen Coicis, put in pot, fry at the temperature of 115-125 DEG C, fry 16-28 minute, take out, cool, be ground into fine powder, cross No. seven sieves;

(3) all the other the 12 taste crude drug except Flos Chrysanthemi Indici and Semen Coicis are ground to the powder altogether, cross No. seven sieves;

(4) step (1), step (2) and step (3) gained are mixed, in the baking oven of 55 DEG C, dry 4-8 hour (preferably in the baking oven of 55 DEG C dry 5 hours), often to wrap 4g subpackage, encapsulates and get final product.

5. the preparation method of the Chinese medicine preparation for the treatment of otitis media as claimed in claim 4, is characterized in that, drying 6 hours in step (1).

6. the preparation method of the Chinese medicine preparation for the treatment of otitis media as claimed in claim 4, is characterized in that, fry in step (2) at the temperature of 120 DEG C.

7. the preparation method of the Chinese medicine preparation for the treatment of otitis media as claimed in claim 4, is characterized in that, fry 22 minutes in step (2).

8. the Chinese medicine preparation of the treatment otitis media as described in as arbitrary in claims 1 to 3, it is characterized in that, the Chinese medicine preparation of this treatment otitis media is made pharmaceutically acceptable pill, and the preparation method of described pill is:

(1) Flos Chrysanthemi Indici being put into temperature is in the baking oven of 50 DEG C, and dry 5-7 hour (preferably dry 6 hours), take out, cool, be ground into fine powder, cross No. five sieves;

(2) get Semen Coicis, put in pot, at the temperature of 115-125 DEG C (preferably at the temperature of 120 DEG C), fry 16-28 minute (preferably frying 22 minutes), take out, cool, be ground into fine powder, cross No. five sieves;

(3) all the other the 12 taste crude drug except Flos Chrysanthemi Indici and Semen Coicis are ground to the powder altogether, cross No. five sieves;

(4) step (1), step (2) and step (3) gained are mixed, with the general ball of vinegar, make the pill of the heavy 0.05g of every ball, dry, to obtain final product.

9. the Chinese medicine preparation of the treatment otitis media as described in as arbitrary in claims 1 to 3, it is characterized in that, the Chinese medicine preparation of this treatment otitis media is made pharmaceutically acceptable granule, and the preparation method of described granule is:

(1) Flos Chrysanthemi Indici being put into temperature is in the baking oven of 50 DEG C, and dry 5-7 hour (preferably dry 6 hours), take out, cool, be ground into fine powder, cross No. five sieves;

(2) get Semen Coicis, put in pot, at the temperature of 115-125 DEG C (preferably at the temperature of 120 DEG C), fry 16-28 minute (preferably frying 22 minutes), take out, cool, be ground into fine powder, cross No. five sieves;

(3) all the other the 12 taste crude drug except Flos Chrysanthemi Indici and Semen Coicis are ground to the powder altogether, cross No. five sieves;

(4) step (1), step (2) and step (3) gained are mixed, add dextrin, the weight of dextrin is step (1), the weight of the preferred dextrin of 1/10-1/5(of step (2) and step (3) gained gross weight is 1/8 of step (1), step (2) and step (3) gained gross weight), mixing, add 95% ethanol and regulate viscosity, agglomerating to hold, namely faling apart of pine, hold imperceptible viscosity for degree, mixing, crosses 20 mesh sieves and granulates, 50 DEG C of dryings 12 hours, with 10 mesh sieve granulate, to obtain final product.

10. the Chinese medicine preparation of the treatment otitis media as described in as arbitrary in claims 1 to 3, it is characterized in that, the Chinese medicine preparation of this treatment otitis media is made pharmaceutically acceptable tablet, and the preparation method of described tablet is:

(1) Flos Chrysanthemi Indici being put into temperature is in the baking oven of 50 DEG C, and dry 5-7 hour (preferably dry 6 hours), take out, cool, be ground into fine powder, cross No. five sieves;

(2) get Semen Coicis, put in pot, at the temperature of 115-125 DEG C (preferably at the temperature of 120 DEG C), fry 16-28 minute (preferably frying 22 minutes), take out, cool, be ground into fine powder, cross No. five sieves;

(3) all the other the 12 taste crude drug except Flos Chrysanthemi Indici and Semen Coicis are ground to the powder altogether, cross No. five sieves;

(4) step (1), step (2) and step (3) gained are mixed, add dextrin, the weight of dextrin is step (1), the weight of the preferred dextrin of 1/10-1/5(of step (2) and step (3) gained gross weight is 1/8 of step (1), step (2) and step (3) gained gross weight), mixing, add 95% ethanol and regulate viscosity, agglomerating to hold, namely faling apart of pine, hold imperceptible viscosity for degree, mixing, cross 20 mesh sieves and granulate, 50 DEG C of dryings 12 hours, tabletting, the heavy 0.4g of every sheet, to obtain final product.