CN103211997A - Antibacterial and antiviral traditional Chinese medicine composition and preparation method thereof - Google Patents
Antibacterial and antiviral traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicines, in particular to an antibacterial and antiviral traditional Chinese medicine composition and a preparation method thereof. The antibacterial and antiviral traditional Chinese medicine composition comprises perilla leaf, angelica dahurica, chastetree fruit, kudzu root, fructus forsythiae, south isatis root, dandelion, houttuynia cordata, verbena, blackberry lily, reed rhizome, rhizoma anemarrhenae, evodia lepta, gypsum, rehmanniae root, sweet wormwood, coix seeds, wax gourd seeds, dark plum, liquorice and platycodon grandiflorum. The preparation method of the antibacterial and antiviral traditional Chinese medicine composition comprises the following steps of: mixing medicinal materials perilla leaf, angelica dahurica and chastetree fruit to obtain a medicinal material mixture; grinding the medicinal material mixture into powder; and preparing the medicinal material mixture into a Chinese materia medica preparation. The antibacterial and antiviral traditional Chinese composition is formed by combining Chinese herbal medicinal ingredients, avoids a side effect produced by taking western medicine, also can realize the aim that multiple diseases are treated by one formula and is applicable to various diseases.
Description
Technical field
The present invention relates to the field of Chinese medicines, in particular to Chinese medicine composition method of a kind of anti-bacteria and anti-virus and preparation method thereof.
Background technology
People's bacterial infection or virus can cause various diseases, comprise all kinds of flu, and the syndrome of WEI system in the calentura, syndrome in QI system, syndrome of disease involving weifen and qifen are got angry or the like, perhaps the complication of above disease.
But in the correlation technique, if the drug main Western medicine of treatment antibacterial or disease of viral infection, comprise Western medicine such as antihistaminic class medicine, antibiotic or antibiotics, but take these medicines for a long time and can produce toxic and side effects human body, for example antihistaminic class medicine has system that inhibitory action is arranged to nervus centralis, and period in a medicine influences work; Antibiotic or antibiotic medicine can cause hemopoietic system hepatorenal damage etc.
Summary of the invention
The object of the present invention is to provide Chinese medicine composition method of a kind of anti-bacteria and anti-virus and preparation method thereof, to solve the above problems.
A kind of Chinese medicine composition of anti-bacteria and anti-virus is provided in an embodiment of the present invention, has comprised:
By weight, Folium Perillae 1-5 part, Radix Angelicae Dahuricae 1-5 part, Fructus Viticis 1-5 part, Radix Puerariae 1-5 part, Fructus Forsythiae 2-10 part, Rhizoma Et Radix Baphicacanthis Cusiae 2-10 part, Herba Taraxaci 2-14 part, Herba Houttuyniae 2-14 part, Herba Verbenae 2-10 part, Rhizoma Belamcandae 2-14 part, Rhizoma Phragmitis 1-7 part, Rhizoma Anemarrhenae 1-7 part, the bitter 1-13 part of three forks, Gypsum Fibrosum 2-14 part, Radix Rehmanniae 1-7 part, Herba Artemisiae Annuae 1-4 part, Semen Coicis 1-7 part, Semen Benincasae 1-5 part, Fructus Mume 1-9 part, Radix Glycyrrhizae 1-5 part, Radix Platycodonis 1-4 part.
A kind of preparation method of Chinese medicine composition of anti-bacteria and anti-virus also is provided in an embodiment of the present invention, has comprised the following steps:
Steps A: with Folium Perillae, the Radix Angelicae Dahuricae, Fructus Viticis, Radix Puerariae, Fructus Forsythiae, Rhizoma Et Radix Baphicacanthis Cusiae, Herba Taraxaci, Herba Houttuyniae, Herba Verbenae, Rhizoma Belamcandae, Rhizoma Phragmitis, the Rhizoma Anemarrhenae, three fork hardships, Gypsum Fibrosum, the Radix Rehmanniae, Herba Artemisiae Annuae, Semen Coicis, Semen Benincasae, Fructus Mume, Radix Glycyrrhizae, Radix Platycodonis mixes, and obtains the medical material mixture;
Step B: with described medical material mixture grind into powder;
Step C: the powder of described medical material mixture is made Chinese medicine preparation.
The Chinese medicine composition of the anti-bacteria and anti-virus of the above embodiment of the present invention has comprised 21 kinds of Chinese crude drugs, can be used for treating the disease that antibacterial and viral infection cause, and the complication of these diseases, be mainly used in treatment wind and cold, anemopyretic cold, syndrome of WEI system in the heat syndrome, syndrome in QI system, the syndrome of disease involving weifen and qifen and the three class diseases of getting angry, and in the Chinese medicine books and periodicals, all can find and not contain the toxic and side effects composition in this Chinese medicine composition, avoided taking the toxic and side effects that Western medicine produces, the composition principle of this Chinese medicine composition monarch is:
Folium Perillae, the Radix Angelicae Dahuricae, Fructus Viticis, Radix Puerariae, Fructus Forsythiae, Rhizoma Et Radix Baphicacanthis Cusiae, Herba Taraxaci, Herba Houttuyniae, Herba Verbenae, the Rhizoma Belamcandae heat-clearing and toxic substances removing that can induce sweat, ten is monarch drug altogether; Rhizoma Phragmitis, the Rhizoma Anemarrhenae, three fork hardships, Gypsum Fibrosum clearing away heat-fire, the Radix Rehmanniae, Herba Artemisiae Annuae clearing away heat and cooling blood, Semen Coicis, the Semen Benincasae clearing away heat and discharging pus, eight is ministerial drug altogether; Fructus Mume and Radix Glycyrrhizae treatment are held concurrently and are pressed from both sides disease, and coordinating the actions of various ingredients in a prescription is combined into adjuvant drug, and Radix Platycodonis is priming, as messenger drug;
In the preparation method of above-mentioned Chinese medicine composition provided by the invention, by described steps A to C totally three steps make Chinese medicine composition, can be used for treating the disease that antibacterial and viral infection cause, its clinical using method is:
Be used for the treatment of and have some inkling of a cold and light disease each 2g, one day three times; Be used for the treatment of flu mid-term and serious symptom, each 3-4g, one day three times; Be used for the treatment of syndrome of WEI system, syndrome in QI system, syndrome of disease involving weifen and qifen or hyperpyrexia, each 4g, one day three times; Be used for the treatment of and get angry, each 2g, one day three times; Be used for the treatment of other infectious disease, look the each 2-4g of state of an illness weight, one day three times; And the mode of taking of this Chinese medicine composition is based on oral.
In addition, through evidence, medicine of the present invention is 93.8% to fever patient's effective percentage, is 95.6% to acute tonsillitis patient's effective percentage, is 100% to flu patient's effective percentage.In a word, medicine of the present invention is combined by Chinese medicine ingredients, has avoided taking the side effect that Western medicine produces, and can realize a kind of purpose of the treatment various disease conditions of filling a prescription simultaneously, and indication is wide.
The specific embodiment
Below by specific embodiment the present invention is described in further detail.
Embodiment one
Embodiments of the invention one provide a kind of Chinese medicine composition of anti-bacteria and anti-virus, comprising:
By weight, Folium Perillae 1-5 part, Radix Angelicae Dahuricae 1-5 part, Fructus Viticis 1-5 part, Radix Puerariae 1-5 part, Fructus Forsythiae 2-10 part, Rhizoma Et Radix Baphicacanthis Cusiae 2-10 part, Herba Taraxaci 2-14 part, Herba Houttuyniae 2-14 part, Herba Verbenae 2-10 part, Rhizoma Belamcandae 2-14 part, Rhizoma Phragmitis 1-7 part, Rhizoma Anemarrhenae 1-7 part, the bitter 1-13 part of three forks, Gypsum Fibrosum 2-14 part, Radix Rehmanniae 1-7 part, Herba Artemisiae Annuae 1-4 part, Semen Coicis 1-7 part, Semen Benincasae 1-5 part, Fructus Mume 1-9 part, Radix Glycyrrhizae 1-5 part, Radix Platycodonis 1-4 part.
21 kinds of Chinese medicinal components in the above-mentioned Chinese medicine composition can be selected any umber in its parts by weight scope for use.
Embodiment two
Embodiments of the invention two provide the Chinese medicine composition of another kind of preferred anti-bacteria and anti-virus, comprising:
By weight, Folium Perillae 3-4 part, Radix Angelicae Dahuricae 3-4 part, Fructus Viticis 3-4 part, Radix Puerariae 3-4 part, Fructus Forsythiae 5-7 part, Rhizoma Et Radix Baphicacanthis Cusiae 5-7 part, Herba Taraxaci 6-10 part, Herba Houttuyniae 6-10 part, Herba Verbenae 5-7 part, Rhizoma Belamcandae 6-10 part, Rhizoma Phragmitis 2-6 part, Rhizoma Anemarrhenae 2-6 part, the bitter 4-9 part of three forks, Gypsum Fibrosum 6-10 part, Radix Rehmanniae 3-5 part, Herba Artemisiae Annuae 1-4 part, Semen Coicis 3-5 part, Semen Benincasae 3-4 part, Fructus Mume 1-9 part, Radix Glycyrrhizae 3-4 part, Radix Platycodonis 1-4 part.
Equally, 21 kinds of Chinese medicinal components in the Chinese medicine composition of embodiment two can be selected any umber in its parts by weight scope for use.
Embodiment three
Embodiments of the invention three provide the Chinese medicine composition of another kind of preferred anti-bacteria and anti-virus, comprising:
By weight, 3 parts of Folium Perillae, 3 parts of the Radixs Angelicae Dahuricae, 3 parts of Fructus Viticises, 3 parts of Radix Puerariaes, 6 parts of Fructus Forsythiaes, 5.8 parts of Rhizoma Et Radix Baphicacanthis Cusiaes, 8 parts of Herba Taraxacis, 8 parts of Herba Houttuyniae, 6 parts of Herba Verbenae, 8 parts of Rhizoma Belamcandae, 4 parts of Rhizoma Phragmitiss, 4 parts of the Rhizoma Anemarrhenaes, bitter 7 parts of three forks, 8 parts in Gypsum Fibrosum, 4 parts in the Radix Rehmanniae, 2.2 parts of Herba Artemisiae Annuaes, 4 parts of Semen Coiciss, 3 parts of Semen Benincasaes, 5 parts of Fructus Mumes, 3 parts in Radix Glycyrrhizae, 2 parts of Radix Platycodoniss.
The Chinese medicine composition of above-mentioned three embodiment has all comprised 21 kinds of Chinese crude drugs, can reach following effect:
Can be used for treating antibacterial and viral infection causes disease, and the complication of these diseases, be mainly used in treatment wind and cold, anemopyretic cold, syndrome of WEI system in the heat syndrome, syndrome in QI system, the syndrome of disease involving weifen and qifen and the three class diseases of getting angry, and in the Chinese medicine books and periodicals, all can find and do not contain the toxic and side effects composition in this Chinese medicine composition, avoided taking the toxic and side effects that Western medicine produces, the composition principle of this Chinese medicine composition monarch is:
Folium Perillae, the Radix Angelicae Dahuricae, Fructus Viticis, Radix Puerariae, Fructus Forsythiae, Rhizoma Et Radix Baphicacanthis Cusiae, Herba Taraxaci, Herba Houttuyniae, Herba Verbenae, the Rhizoma Belamcandae heat-clearing and toxic substances removing that can induce sweat, ten is monarch drug altogether; Rhizoma Phragmitis, the Rhizoma Anemarrhenae, three fork hardships, Gypsum Fibrosum clearing away heat-fire, the Radix Rehmanniae, Herba Artemisiae Annuae clearing away heat and cooling blood, Semen Coicis, the Semen Benincasae clearing away heat and discharging pus, eight is ministerial drug altogether; Fructus Mume and Radix Glycyrrhizae treatment are held concurrently and are pressed from both sides disease, and coordinating the actions of various ingredients in a prescription is combined into adjuvant drug, and Radix Platycodonis is priming, as messenger drug.
The clinical using method of above-mentioned Chinese medicine composition is:
Be used for the treatment of and have some inkling of a cold and mild case each 2g, one day three times; Be used for the treatment of flu mid-term and serious symptom, each 3-4g, one day three times; Be used for the treatment of syndrome of WEI system, syndrome in QI system, syndrome of disease involving weifen and qifen or hyperpyrexia, each 4g, one day three times; Be used for the treatment of and get angry, each 2g, one day three times; Be used for the treatment of other infectious disease, look the each 2-4g of state of an illness weight, one day three times.
In addition, through evidence, Chinese medicine composition of the present invention is 93.8% to fever patient's effective percentage, effective percentage to the acute tonsillitis patient is 95.6%, effective percentage to the flu patient is 100%, and acute pharyngitis, bronchitis, aphtha, eye hordeolum, herpes simplex, urinary system infection, otitis media, gingivitis, furuncle enteritis, sinusitis, acute conjunctivitis etc. are all had therapeutic effect.
In a word, Chinese medicine composition of the present invention is combined by Chinese medicine ingredients, has not only avoided taking the side effect that Western medicine produces, and can realize a kind of purpose of the treatment various disease conditions of filling a prescription simultaneously, and indication is wide.Simultaneously the drug component mentioned of above-mentioned three embodiment can adopt any umber in its corresponding umber scope, all can reach above-mentioned effect.
In addition, with respect to the existing antibiotics and the antibiotic that can reach the identical treatment effect, because compositions of the present invention has comprised multiple ingredient, the composition variation, thereby antibacterial and viral being difficult for to its generation drug resistance, thereby with respect to existing antibiotics and antibiotic, this compositions range of application is wider.The characteristics of the medicine of simultaneously existing treatment antibacterial or disease of viral infection are: a kind of medicine can only be treated a kind of disease, when patient suffers from multiple disease simultaneously (for example complication), need take multiple medicine usually, has increased patient's burden; Pharmaceutical composition of the present invention has then been avoided this puzzlement, and it has comprised the plurality of Chinese component, can treat the multiple disease that antibacterial or viral infection cause, the pharmacology of said composition and the provable this point of clinical practice situation.
The pharmacology of Chinese medicine composition of the present invention is as follows in detail:
Folium Perillae, Fructus Forsythiae, Rhizoma Et Radix Baphicacanthis Cusiae, Herba Taraxaci, Herba Houttuyniae, Herba Verbenae, the Rhizoma Anemarrhenae, three fork hardships have broad-spectrum antibacterial action, and staphylococcus, escherichia coli, dysentery bacterium, Hemolytic streptococcus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera, bordetella pertussis, tubercule bacillus, Diplococcus pneumoniae, bacillus subtilis, bacillus enteritidis, micrococcus catarrhalis, diphtheria corynebacterium are killed or inhibitory action.
Fructus Forsythiae, Rhizoma Et Radix Baphicacanthis Cusiae, Herba Houttuyniae, Rhizoma Belamcandae, three fork hardships have the broad-spectrum disease resistance toxic action, and common cold virus, influenza virus are had inhibitory action.
The Herba Houttuyniae clearing the nasal passage is controlled rhinitis, the sinusitis of polytype, eliminates nasal obstruction.
Herba Verbenae, Rhizoma Belamcandae, Gypsum Fibrosum reduce the blood vessel wall permeability, reduce inflammatory exudation, eliminate rhinorrhea.
The Radix Rehmanniae, Radix Glycyrrhizae, Semen Benincasae have antiinflammatory, antiallergic, the effect of glucocorticoid sample.
Herba Houttuyniae, Rhizoma Belamcandae, the Rhizoma Anemarrhenae, Radix Puerariae can be expanded cerebral arteries and crown tremulous pulse, improve myocardial ischemia and cerebral blood circulation.
The Radix Rehmanniae has cardiotonic
Fructus Viticis, the Radix Angelicae Dahuricae, Herba Houttuyniae, Herba Verbenae, Gypsum Fibrosum have analgesic activity.
Folium Perillae, Radix Puerariae, Fructus Forsythiae, Rhizoma Et Radix Baphicacanthis Cusiae, Herba Verbenae, the Rhizoma Anemarrhenae, three fork hardships, Gypsum Fibrosum have refrigeration function.
The effect of bringing high blood pressure down of Radix Puerariae, Rhizoma Belamcandae.
Fructus Forsythiae, Herba Houttuyniae, the Rhizoma Anemarrhenae have diuresis.
Rhizoma Et Radix Baphicacanthis Cusiae, Herba Houttuyniae, Gypsum Fibrosum strengthen phagocytic activity of leukocytes, enhancing body resistance.
Rhizoma Et Radix Baphicacanthis Cusiae is controlled aphtha.
Herba Taraxaci, Herba Houttuyniae, three fork hardships can treat that furuncle swells and ache, the furunculosis breast ulcer.
Herba Taraxaci is controlled conjunctivitis, blepharitis, hordeolum.
Folium Perillae, Herba Taraxaci are controlled upper respiratory tract infection, reduce bronchial secretion, alleviate bronchospasm, relieving cough and asthma.
Rhizoma Belamcandae, three fork hardships, Gypsum Fibrosum treatment tonsillitis, pharyngolaryngitis.
Herba Houttuyniae has antibacterial action to the drug-fast antibacterial of antibiotics, can treat enteritis, dysentery.
Herba Taraxaci can be treated pelvic inflammatory disease, acute appendicitis, cholecystitis, urinary system infection.
The present invention also provides the preparation method of the Chinese medicine composition of above-mentioned anti-bacteria and anti-virus.
Embodiment four:
The preparation method of the Chinese medicine composition of the anti-bacteria and anti-virus of above mentioning comprises the following steps:
Step 101: with Folium Perillae, the Radix Angelicae Dahuricae, Fructus Viticis, Radix Puerariae, Fructus Forsythiae, Rhizoma Et Radix Baphicacanthis Cusiae, Herba Taraxaci, Herba Houttuyniae, Herba Verbenae, Rhizoma Belamcandae, Rhizoma Phragmitis, the Rhizoma Anemarrhenae, three fork hardships, Gypsum Fibrosum, the Radix Rehmanniae, Herba Artemisiae Annuae, Semen Coicis, Semen Benincasae, Fructus Mume, Radix Glycyrrhizae, Radix Platycodonis mixes, and obtains the medical material mixture;
Step 102: with described medical material mixture grind into powder;
Step 103: the powder of described medical material mixture is made Chinese medicine preparation.
In the above-mentioned preparation method, by described step 101 to 103 totally three steps make Chinese medicine composition, can be used for treating the disease that antibacterial and viral infection cause.
What wherein, described Chinese medicine preparation can be in following is a kind of: capsule, pill, tablet, powder.These preparations all are suitable for directly oral, and more convenient patient takes.
Preferably, when being prepared as capsule preparations, the described Chinese medicine preparation of making comprises: the powder of described medical material mixture is incapsulated.Wherein preferably, described capsule is No. 0 gastric-dissolved capsule.
In addition, the granularity of powder described in the described step 102 is the 100-300 order, and more preferably, the granularity of described powder is the 150-300 order.
Embodiment five
Present embodiment provides Chinese medicine composition of a kind of preferred anti-bacteria and anti-virus and preparation method thereof, and wherein Chinese medicine composition adopts the proportioning of the foregoing description three, and preparation method is:
Step 201: with Folium Perillae, the Radix Angelicae Dahuricae, Fructus Viticis, Radix Puerariae, Fructus Forsythiae, Rhizoma Et Radix Baphicacanthis Cusiae, Herba Taraxaci, Herba Houttuyniae, Herba Verbenae, Rhizoma Belamcandae, Rhizoma Phragmitis, the Rhizoma Anemarrhenae, three fork hardships, Gypsum Fibrosum, the Radix Rehmanniae, Herba Artemisiae Annuae, Semen Coicis, Semen Benincasae, Fructus Mume, Radix Glycyrrhizae, Radix Platycodonis mixes, and obtains the medical material mixture;
Step 202: with described medical material mixture grind into powder;
Step 203:, make capsule preparations with the powder of the described medical material mixture gastric solubility capsule of packing into No. 0.
Every content of dispersion of the capsule that the foregoing description five finally makes is 0.5 ± 0.02g.
The clinical practice situation
The product that used Chinese medicine composition of the present invention all provides for embodiment five in all following clinical practices.
In order further to describe performance of the present invention in detail, below provide three routine patients to cure situation at three kinds of various disease.
Flu clinical practice example
Zhang, the woman, 48 years old, symptom was: nasal obstruction rhinorrhea one day, because of the onset of suffering from cold,, be with more clear rare nasal mucus then, with nasal obstruction from the beginning of aversion to wind, itching of the throat, sneeze, take WEI C YINQIAO PIAN and do not take a turn for the better in 1 day, the tongue fur floating pulse that whitens; Be diagnosed as anemofrigid cold.Take medicine of the present invention, each 5, one day three times, above-mentioned symptom alleviates after taking medicine one day, continues to take medicine two days, and the symptom complete obiteration is cured.
Heating clinical practice example
Go into business certain, the man, 30 years old, symptom was: mouth and nose are warmed, fear of cold, headache, systemic pain half a day, flushing, yellow fur, rapid pulse, 39.2 ℃ of body temperature are diagnosed as calentura from the beginning of syndrome of WEI system.Take medicine of the present invention, each 8, one day three times, after taking medicine one day, above-mentioned symptom disappears, and 37 ℃ of body temperature are cured.
Acute tonsillitis clinical practice example
Zhang, the man, 27 years old, symptom was: had sore throat one day, from the beginning of conscious fear of cold, heating, headache, systemic pain, thirsty, irritated, pharyngalgia is obvious, thick, the full and large pulse of red tongue with yellow fur, there are several yellow-white pus points, 39.8 ℃ of body temperature in antiadoncus, hyperemia, surface.Be diagnosed as acute tonsillitis.Take medicine of the present invention, one time 8, one day three times, took medicine one day, above-mentioned symptom alleviates, body temperature is reduced to 37.8 ℃, take again this medicine two days later symptom eliminate fully, the congested enlargement of tonsil is disappeared, 37 ℃ of body temperature are cured.
Except that above-mentioned three routine clinical practices, also be useful on the clinical example of other disease, but differ at this and one to enumerate, simultaneously in order more to prove absolutely the performance of this compositions, the present invention has also made statistics to Chinese medicine composition applicable cases clinically: clinical total treatment example is 1739 examples, total effective rate is up to 91.3%, and each treatment of diseases situation is shown in table 1, table 2, table 3.
Table 1 the present invention is to the treatment situation of various disease
Table 2 the present invention is to the treatment situation of various disease
Table 3 the present invention is to the treatment situation of various disease
By data in above-mentioned three tables as can be known, multiple diseases such as medicine of the present invention can be used for the treatment of heating, acute pharyngitis, acute tonsillitis, flu, bronchitis, aphtha, eye hordeolum, herpes simplex, urinary system infection, gets angry, otitis media, gingivitis, furuncle, enteritis, sinusitis, acute conjunctivitis, and higher effective rate (being meant effectively and taking in the medicine of the present invention seven days that the symptom of each disease is all eliminated) is arranged all.Wherein, the treatment flu is totally 696 examples, and effective percentage is 100%.Treatment acute tonsillitis (and gas is with sick) is totally 110 examples, and effective percentage is 96.4%.
In addition, the present invention has also made contrast test respectively with the curative effect of Chinese medicine composition of the present invention and compound recipe cold drug, amoxicillin.
The curative effect of the present invention and compound recipe cold drug treatment flu relatively
The diagnostic criteria of flu: sneeze, rhinorrhea, nasal obstruction.
Curative effect is divided into healing, produce effects, effective three ranks, and " effective percentage " is meant three ratios that rank is total, three other evaluation criterions of level are:
Cure: took medicine three to four days, all transference cures, drug withdrawal does not have recurrence.
Produce effects: took medicine three to four days, all transference cures, end-of-dose failure need be kept medication to the seven days.
Effectively: took medicine three to four days, sx, not complete obiteration need be kept medication to the seven days.
Case is selected:
52 example flu patients are divided into test group and matched group at random, and test group is taken medicine of the present invention, and matched group is taken the compound recipe cold drug.Each 26 example of test group and matched group are of the similar age for two groups, are 18 to 58 years old, and the mean age was respectively 36.5 years old and 36.6 years old, each 18 example of male, each 8 example of women, clinical manifestation is similar, through t check, two groups are not had significant difference p〉0.05, thereby two groups have comparability.
Therapeutic Method:
Administration is each four during the test group first visit, and three times on the one, oral medication three days.
Administration is each 4 during the matched group first visit, and three times on the one, oral medication three days.
The result:
Disappearance person in the sneeze, rhinorrhea 2 hours: test group is 25 examples, accounts for 96%, average regression time 1.5 hours; And matched group accounts for 77%, average regression time 2.1 hours.
Disappearance person in 4 hours has a stuffy nose: test group is 21 examples, accounts for 80.7%, and average regression time is 3.3 hours; Matched group accounts for 61%, and average regression time is 4 hours.
Through the t check, aspect elimination sneeze, rhinorrhea, nasal obstruction, test group all is better than matched group, two groups of curative effect significant differences.
In addition, also compared two groups of back inhibition situations of taking medicine, estimated symptom and comprise: lassitude, tired, drowsiness, dizzy nervus centralis.
Table 4 the present invention and compound recipe cold drug are to the inhibition situation of nervus centralis
| Symptom | Lassitude | Tired | Drowsiness | Dizzy |
| Test group percentage ratio | 0 | 0 | 0 | 0 |
| Matched group percentage ratio | 34.6% | 26.9% | 23.1% | 15.4% |
Comparative result by above-mentioned curative effect and side effect can find out that with respect to the compound recipe cold drug, the present invention is not only more effective to flu, and human body is had no side effect, and period in a medicine does not influence patient's operate as normal.
The curative effect of the present invention and amoxicillin treatment acute tonsillitis relatively
The diagnostic criteria of acute tonsillitis:
Tcm diagnosis: simultaneous occurrence of syndromes of both QI and WEI systems, aversion to cold, hyperpyrexia, headache, systemic pain, thirsty, red tongue with yellow fur, floating and rapid pulse or loud sliding number.
Western medicine diagnose: onset is anxious, and the headache of fear of cold hyperpyrexia is arranged, systemic pain, and pharyngalgia is obvious, and check and see the pharyngeal recess acute congestion, antiadoncus, there is the yellow-white pustule on the surface, and crypts has yellow-white point-like exudate, and the hemogram leukocyte is more, body temperature 38.3-39.5 ℃.
Curative effect is divided into healing, produce effects, effective, invalid four ranks, and " effective percentage " is meant the ratio that first three rank is total, four other evaluation criterions of level are:
Recovery from illness: took medicine four days, the symptom complete obiteration, hyperpyrexia moves back to the greatest extent, the congested swelling of tonsil is disappeared, crypts does not have purulent secretion, it is normal that hemogram recovers, Be is white for the light red tongue tongue, arteries and veins one expiration and inspiration five to.
Produce effects: took medicine 4 days, the state of an illness is clearly better, but above-mentioned symptom has one to two not recover normal.
Effectively: body temperature disappears, and symptom partly disappears, the congested swelling of tonsil.
Invalid: symptom and sign does not have improvement.
Case is selected:
Patient's 205 examples being diagnosed as acute tonsillitis in the outpatient service are divided into test group and matched group at random, and test group is taken Chinese medicine composition of the present invention, and matched group is taken the amoxicillin.
Test group 110 examples, male's 64 examples, women's 46 examples.
Matched group 95 examples, male's 51 examples, women's 44 examples.
Be of the similar age for two groups, be 20 to 58 years old.Mean age was respectively 38.5 years old and 38.7 years old, and clinical manifestation is similar, and through the t check, two groups are not had significant difference p〉0.05, have comparability.
Therapeutic Method:
Test group is taken Chinese medicine composition of the present invention, each 8, one day three times, orally serve on 4 days.
Matched group is taken the amoxicillin, and each 0.5g one day four times, serve on four days.
Curative effect:
It is as shown in the table, and the effective percentage of test group is 96.4%, and the effective percentage of matched group is 97.9%.
The curative effect comparative result of table 5 the present invention and amoxicillin treatment acute tonsillitis
| Medicine | Cure | Significantly | Effectively | Invalid |
| Test group | 77.3% | 11.8% | 7.3% | 3.6% |
| Matched group | 75.8% | 13.6% | 5.3% | 5.3% |
Conclusion:
Through t check, P〉0.05, two group compare no significant difference, visible Chinese medicine composition of the present invention is similar with the amoxicillin effect, treats the acute tonsillitis therapeutic equivalence.But compare the amoxicillin, Chinese medicine composition of the present invention can not cause allergic reaction, and range of application is wider.
The above is the preferred embodiments of the present invention only, is not limited to the present invention, and for a person skilled in the art, the present invention can have various changes and variation.Within the spirit and principles in the present invention all, any modification of being done, be equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. the Chinese medicine composition of an anti-bacteria and anti-virus is characterized in that, comprising:
By weight, Folium Perillae 1-5 part, Radix Angelicae Dahuricae 1-5 part, Fructus Viticis 1-5 part, Radix Puerariae 1-5 part, Fructus Forsythiae 2-10 part, Rhizoma Et Radix Baphicacanthis Cusiae 2-10 part, Herba Taraxaci 2-14 part, Herba Houttuyniae 2-14 part, Herba Verbenae 2-10 part, Rhizoma Belamcandae 2-14 part, Rhizoma Phragmitis 1-7 part, Rhizoma Anemarrhenae 1-7 part, the bitter 1-13 part of three forks, Gypsum Fibrosum 2-14 part, Radix Rehmanniae 1-7 part, Herba Artemisiae Annuae 1-4 part, Semen Coicis 1-7 part, Semen Benincasae 1-5 part, Fructus Mume 1-9 part, Radix Glycyrrhizae 1-5 part, Radix Platycodonis 1-4 part.
2. the Chinese medicine composition of a kind of anti-bacteria and anti-virus according to claim 1 is characterized in that, comprising:
By weight, Folium Perillae 3-4 part, Radix Angelicae Dahuricae 3-4 part, Fructus Viticis 3-4 part, Radix Puerariae 3-4 part, Fructus Forsythiae 5-7 part, Rhizoma Et Radix Baphicacanthis Cusiae 5-7 part, Herba Taraxaci 6-10 part, Herba Houttuyniae 6-10 part, Herba Verbenae 5-7 part, Rhizoma Belamcandae 6-10 part, Rhizoma Phragmitis 2-6 part, Rhizoma Anemarrhenae 2-6 part, the bitter 4-9 part of three forks, Gypsum Fibrosum 6-10 part, Radix Rehmanniae 3-5 part, Herba Artemisiae Annuae 1-4 part, Semen Coicis 3-5 part, Semen Benincasae 3-4 part, Fructus Mume 1-9 part, Radix Glycyrrhizae 3-4 part, Radix Platycodonis 1-4 part.
3. the Chinese medicine composition of a kind of anti-bacteria and anti-virus according to claim 2 is characterized in that, comprising:
By weight, 3 parts of Folium Perillae, 3 parts of the Radixs Angelicae Dahuricae, 3 parts of Fructus Viticises, 3 parts of Radix Puerariaes, 6 parts of Fructus Forsythiaes, 5.8 parts of Rhizoma Et Radix Baphicacanthis Cusiaes, 8 parts of Herba Taraxacis, 8 parts of Herba Houttuyniae, 6 parts of Herba Verbenae, 8 parts of Rhizoma Belamcandae, 4 parts of Rhizoma Phragmitiss, 4 parts of the Rhizoma Anemarrhenaes, bitter 7 parts of three forks, 8 parts in Gypsum Fibrosum, 4 parts in the Radix Rehmanniae, 2.2 parts of Herba Artemisiae Annuaes, 4 parts of Semen Coiciss, 3 parts of Semen Benincasaes, 5 parts of Fructus Mumes, 3 parts in Radix Glycyrrhizae, 2 parts of Radix Platycodoniss.
4. according to the preparation method of the Chinese medicine composition of each described a kind of anti-bacteria and anti-virus of claim 1-3, it is characterized in that, comprise the following steps:
Steps A: with Folium Perillae, the Radix Angelicae Dahuricae, Fructus Viticis, Radix Puerariae, Fructus Forsythiae, Rhizoma Et Radix Baphicacanthis Cusiae, Herba Taraxaci, Herba Houttuyniae, Herba Verbenae, Rhizoma Belamcandae, Rhizoma Phragmitis, the Rhizoma Anemarrhenae, three fork hardships, Gypsum Fibrosum, the Radix Rehmanniae, Herba Artemisiae Annuae, Semen Coicis, Semen Benincasae, Fructus Mume, Radix Glycyrrhizae, Radix Platycodonis mixes, and obtains the medical material mixture;
Step B: with described medical material mixture grind into powder;
Step C: the powder of described medical material mixture is made Chinese medicine preparation.
5. the preparation method of the Chinese medicine composition of a kind of anti-bacteria and anti-virus according to claim 4 is characterized in that, described Chinese medicine preparation is a capsule.
6. the preparation method of the Chinese medicine composition of a kind of anti-bacteria and anti-virus according to claim 5 is characterized in that, the described Chinese medicine preparation of making comprises:
The powder of described medical material mixture is incapsulated.
7. the preparation method of the Chinese medicine composition of a kind of anti-bacteria and anti-virus according to claim 6 is characterized in that, described capsule is No. 0 gastric solubility capsule.
8. the preparation method of the Chinese medicine composition of a kind of anti-bacteria and anti-virus according to claim 4 is characterized in that, the granularity of described powder is the 100-300 order.
9. the preparation method of the Chinese medicine composition of a kind of anti-bacteria and anti-virus according to claim 4 is characterized in that, described Chinese medicine preparation is a kind of in following:
Pill, tablet, powder.
10. the preparation method of the Chinese medicine composition of a kind of anti-bacteria and anti-virus according to claim 8 is characterized in that, the granularity of described powder is the 150-300 order.
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| CN103961575A (en) * | 2014-05-08 | 2014-08-06 | 肖勇 | Chinese patent medicine for treating cold and preparation method thereof |
| CN104840822A (en) * | 2015-06-02 | 2015-08-19 | 岳兵兵 | Traditional Chinese medicine composition for treating otitis media |
| CN104840823A (en) * | 2015-06-02 | 2015-08-19 | 岳兵兵 | Traditional Chinese medicine preparation for treating otitis media and preparation method |
| CN104983944A (en) * | 2015-06-15 | 2015-10-21 | 山东大学 | Compound Chinese herbal medicine anti-microbial anti-viral agent and preparing method and application thereof |
| CN105125741A (en) * | 2015-07-27 | 2015-12-09 | 袁忠祥 | Traditional Chinese medicine having functions of immunity enhancement and longevity improvement and preparation method and application of traditional Chinese medicine |
| CN105748989A (en) * | 2016-03-14 | 2016-07-13 | 赵剑锋 | Anti-bacterial and anti-virus composition and preparation method thereof |
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| CN107854670A (en) * | 2017-11-01 | 2018-03-30 | 罗建平 | Prevent and treat Chinese herbal feed additive of pig anemofrigid cold and preparation method thereof |
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| CN103211997B (en) | 2015-03-25 |
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