CN100512850C - Lung heat-cleaning throat-moistening cough-relieving syrup - Google Patents
Lung heat-cleaning throat-moistening cough-relieving syrup Download PDFInfo
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- CN100512850C CN100512850C CNB2006100471325A CN200610047132A CN100512850C CN 100512850 C CN100512850 C CN 100512850C CN B2006100471325 A CNB2006100471325 A CN B2006100471325A CN 200610047132 A CN200610047132 A CN 200610047132A CN 100512850 C CN100512850 C CN 100512850C
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- cough
- lung heat
- radix
- cleaning throat
- moistening
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Abstract
The invention is concerned with the cough syrup for treating Acute and chronic pharyngitis, respiratory tract infections, the materials is with weight sharing: radix rehmanniae is 6 to 12 shares, dwarf lilyturf root is 9 to 15 shares, fritillary bulb is 9 to 15 shares, mint is 7 to 13 shares, and honeysuckle is 5 to 11 shares. The invention is better curative effect, strong pertinency for the above illnesses.
Description
Technical field:
The present invention relates to treat the Chinese medicine of diseases such as cough that acute and chronic pharyngitis and respiratory tract infection cause, itching throat, pharyngalgia.
Background technology:
Nourishing YIN and clearing away lung-heat Tangyuan County is stated from " Chonglou Yuyao, Jade Key to the Secluded Chamber " (clear Zheng Meijian work) soon, is made up of eight flavor medicines such as the Radix Rehmanniae, Radix Ophiopogonis, Radix Glycyrrhizae, Radix Scrophulariae, Bulbus Fritillariae Cirrhosae, Cortex Moutan, Herba Menthae, Radix Paeoniae Alba (parched).Reuse in the side that the Radix Rehmanniae is sweet trembles with fear into kidney, replenishing YIN and removing heat is monarch drug; The Radix Scrophulariae YIN nourishing and the production of body fluid promoting, eliminating fire and detoxication, nourishing YIN and clearing away lung-heat Radix Ophiopogonis is ministerial drug altogether; Assistant is with the detumescence of Cortex Moutan clearing away heat and cooling blood, and Radix Paeoniae Alba tonifying YIN nourishes blood, Bulbus Fritillariae Cirrhosae moistening the lung and resolving phlegm, heat clearing away eliminating stagnation; A small amount of Herba Menthae is hot cool and loose the relieving the exterior syndrome sore-throat relieving; The Radix Glycyrrhizae eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Modern pharmacological research shows that the Radix Rehmanniae has functions such as antiinflammatory, antiallergic, enhance immunity; Radix Ophiopogonis, energy enhancing human body immunity power improved organism adaptation, and certain antibacterial action is also arranged; Radix Scrophulariae has good inhibition effect to various pathogens such as diphtheria corynebacterium, staphylococcus aureus, Bacillus typhi, also has effects such as antiinflammatory, calmness; Cortex Moutan antiinflammatory, sterilization; Bulbus Fritillariae Cirrhosae antitussive, eliminate the phlegm; The Radix Paeoniae Alba then can make the immunologic function that is in low state recover normal, and good antiinflammatory action is also arranged; Herba Menthae has inhibitory action to multiple virus, antibacterial; That Radix Glycyrrhizae has is antibiotic, antiviral, antiinflammatory, anti-allergic effects, can protect the throat and the tunica mucosa tracheae of inflammation, also have eliminate the phlegm, antitussive, antiasthmatic effect.The original idea of its prescription is in order to treat the extremely strong infectious disease-diphtheria of popular at that time infectiousness.Now because antibiotic application, diphtheria is rare, and the modern times are everlasting clinically and change sanction with treatment face and diseases in respiratory system on this side basis.He Shi treats hypopyretic laryngalgia with nourishing YIN and clearing away lung-heat Tonga flavor side, have certain effect to improving patient's Abwehrkraft des Koepers and the recurrence of minimizing sore throat (He Jianying. nourishing YIN and clearing away lung-heat Tonga distinguishes the flavor of and controls hypopyretic laryngalgia. Chinese patent medicine, 2000.22 (4): 314～315).Li Shi adopts new outer bottleneck throat and the oral nourishing YIN and clearing away lung-heat Tonga flavor treatment chronic pharyngitis of dripping of rehabilitation, curative effect is better, relief of symptoms and few recurrence fast (Li Yunwei. Yangyin Qingfei Tang treatment chronic pharyngolaryngitis clinical experience is newly closed in rehabilitation. Yunnan University of Traditional Chinese Medicine's journal, 2001.24 (2): 32).Liang Shi adds and subtracts with Yangyin Qingfei Tang, to chronic congestion, the swelling of vocal cords mucosa, thicken obtained curative effect (fine strain of millet cloud swallow. the observation of curative effect of Chinese medicine chronic simple laryngitis. Liaoning Journal of Traditional Chinese Medicine, 2003.30 (11): 909).Li Junru selects Yangyin Qingfei Tang to drink to add the product of clearing and dissipating phlegm-heat, make pulmonary infection be able to very fast control (Li Junru. nourishing YIN and clearing away lung-heat Tonga flavor control mechanical ventilation complication 12 examples. Zhejiang Journal of Traditional Chinese Medicine, 2000.35 (7): 284).
In a word, the Yangyin Qingfei Tang compatibility relationship is clear and definite, determined curative effect is remarkable, but the contained flavour of a drug quantity of former side is more, has brought many unfavorable factors such as active substance extraction, quality control, cost control for large-scale industrial production.And disease that former side cures mainly is rare, clinical can't directly the application.
Summary of the invention:
The present invention is exactly at the problems referred to above, provide a kind of curative effect better, the Chinese medicine of diseases such as the cough that causes of the acute and chronic pharyngitis of treatment actual with strong points and respiratory tract infection, itching throat, pharyngalgia.
The present invention adopts following technical scheme:
Crude drug of the present invention consists of: 6-12 parts in the Radix Rehmanniae, 9-15 parts of Radix Ophiopogonis, 9-15 parts of Bulbus Fritillariae Cirrhosaes, 7-13 parts of Herba Menthaes, 5-11 parts of Flos Loniceraes (Flos Lonicerae).
Radix Rehmanniae sweet in the mouth cool in nature, heat clearing away YIN nourishing, removing heat from blood promote the production of body fluid and are monarch drug among the present invention, and Radix Ophiopogonis, Bulbus Fritillariae Cirrhosae, Flos Lonicerae (Flos Lonicerae) are ministerial drug altogether.Support lung heat clearing away, nourishing the lung to arrest cough Radix Ophiopogonis, lung, mutual generation between metal and water are supported in the Radix Rehmanniae, nourishing kidney Radix Ophiopogonis.Bulbus Fritillariae Cirrhosae moistening the lung and resolving phlegm, heat clearing away eliminating stagnation, the sweet cold yin nourishing of Flos Lonicerae (Flos Lonicerae), heat-clearing and toxic substances removing, dispelling wind uncharm, and Herba Menthae suffering tremble with fear, the induce sweat wind heat of loosing is an adjuvant drug.
Beneficial effect of the present invention:
The active drug of diseases such as the cough that acute and chronic pharyngitis of treatment that the present invention system is made by pure Chinese medicine and respiratory tract infection cause, itching throat, pharyngalgia.From Chinese medicine tradition prescription " Yangyin Qingfei Tang " exploitation.Have significant antitussive, antiinflammatory action by the zoopery proof.Have and form simple, advantages such as compatibility is proper, consumption is less, determined curative effect.
Medicine of the present invention can by actual needs make pill, powder or oral liquid etc. traditional form, also can be made into new formulations such as disintegrating tablet, dispersible tablet.
The specific embodiment:
Embodiment 1:
Radix Rehmanniae 27g, Radix Ophiopogonis 36g, Bulbus Fritillariae Cirrhosae 36g, Herba Menthae 30g, Flos Lonicerae (Flos Lonicerae) 24g;
Method for making: conventional decocting boils.
[experimental technique]
1. adopt Mus ear swelling method, 20 male mices are divided into administration group and matched group at random, and gastric infusion is irritated the long-pending 20ml/kg of being of body of stomach respectively, once a day, and continuous 6 days.Behind last filling stomach 1 hour, respectively be coated with dimethylbenzene 20 μ l in each group mouse right ear front-back same area with micropipettor respectively.Put to death animal after 4 hours, cut ears, lay round auricle at same position respectively with card punch.Scales/electronic balance weighing, the difference of auris dextra sheet and left auricle weight is the swelling degree, experimental result adopts SPSS 13.0 for windows One-Way ANOVA to carry out statistical disposition.Result such as following table:
Lung heat-cleaning throat-moistening cough-relieving syrup is to the antiinflammatory action of mice
Annotate: compare with matched group:
*P＜0.01
As seen compare with matched group, the administration group can significantly reduce the mice auricle swelling degree (P＜0.01) that dimethylbenzene causes, illustrates that this prescription has better antiinflammatory action.
2. adopt mice ammonia to draw the method for coughing.20 male and female mices half and half are divided into administration group and matched group at random, and gastric infusion is irritated the long-pending 20ml/kg of being of body of stomach respectively, once a day, and continuous 6 days.Behind last filling stomach 1 hour, mice is placed in the 1500ml glass bell jar, spray in the bell jar by soniclizer that (nebulizer atomization quantity and exhaust air rate all are made as 50%, and the spraying bore is 1cm * 1cm), continue spraying 5 seconds after with ammonia atomization equably by the bottom.Observe cough latent period (the spraying beginning is to the required time of cough takes place) and the cough number of times in 2 minutes of mice.The cough performance is shunk (breast contracts) with abdominal muscle, magnifies mouth simultaneously and is as the criterion.Experimental result adopts SPSS 13.0 for windows One-WayANOVA to carry out statistical disposition.Result such as following table:
Lung heat-cleaning throat-moistening cough-relieving syrup is to the antitussive effect of mice
Annotate: compare with matched group:
*P＜0.01
Compare with matched group as seen from the table, the administration group can significantly reduce the cough number of times (P＜0.01) that ammonia brings out mice, illustrates that this prescription has better antitussive effect.
Embodiment 2:
Radix Rehmanniae 18g, Radix Ophiopogonis 24g, Bulbus Fritillariae Cirrhosae 24g, Herba Menthae 20g, Flos Lonicerae (Flos Lonicerae) 16g;
Method for making: Herba Menthae is pulverized, and adds 4 times of volume water distillations and collects volatile oil in 4 hours, and volatile oil is preserved in 4 ℃ of refrigerators.Medicinal residues and the Radix Rehmanniae, Radix Ophiopogonis, Flos Lonicerae are merged conventional the decoction.Bulbus Fritillariae Cirrhosae 70% alcohol reflux 4 hours reclaims behind the ethanol to mix with aforementioned decocting liquid and concentrates the back and add ethanol to 60% and leave standstill after 24 hours and concentrate, and sneaks into the volatile oil conduct next day and is subjected to test solution.
[experimental technique]
1. adopt Mus ear swelling method, 20 male mices are divided into administration group and matched group at random, and gastric infusion is irritated the long-pending 20ml/kg of being of body of stomach respectively, once a day, and continuous 6 days.Behind last filling stomach 1 hour, respectively be coated with dimethylbenzene 20 μ l in each group mouse right ear front-back same area with micropipettor respectively.Put to death animal after 4 hours, cut ears, lay round auricle at same position respectively with card punch.Scales/electronic balance weighing, the difference of auris dextra sheet and left auricle weight is the swelling degree, experimental result adopts SPSS 13.0 for windows One-WayANOVA to carry out statistical disposition.Result such as following table:
Lung heat-cleaning throat-moistening cough-relieving syrup is to the antiinflammatory action of mice
Annotate: compare with matched group:
*P＜0.01
As seen compare with matched group, lung heat-cleaning throat-moistening cough-relieving syrup can significantly reduce the mice auricle swelling degree (P＜0.01) that dimethylbenzene causes, illustrates that this prescription has better antiinflammatory action.
2. adopt mice ammonia to draw the method for coughing.20 male and female mices half and half are divided into administration group and matched group at random, and gastric infusion is irritated the long-pending 20ml/kg of being of body of stomach respectively, once a day, and continuous 6 days.Behind last filling stomach 1 hour, mice is placed in the 1500ml glass bell jar, spray in the bell jar by soniclizer that (nebulizer atomization quantity and exhaust air rate all are made as 50%, and the spraying bore is 1cm * 1cm), continue spraying 5 seconds after with ammonia atomization equably by the bottom.Observe cough latent period (the spraying beginning is to the required time of cough takes place) and the cough number of times in 2 minutes of mice.The cough performance is shunk (breast contracts) with abdominal muscle, magnifies mouth simultaneously and is as the criterion.Experimental result adopts SPSS 13.0 for windows One-WayANOVA to carry out statistical disposition.Result such as following table:
Lung heat-cleaning throat-moistening cough-relieving syrup is to the antitussive effect of mice
Annotate: compare with matched group:
*P＜0.01
Compare with matched group as seen from the table, the administration group can significantly reduce the cough number of times (P＜0.01) that ammonia brings out mice, illustrates that this prescription has better antitussive effect.
Embodiment 3:
Radix Rehmanniae 9g, Radix Ophiopogonis 12g, Bulbus Fritillariae Cirrhosae 12g, Herba Menthae 10g, Flos Lonicerae (Flos Lonicerae) 8g;
Method for making: Herba Menthae is pulverized, and adds 4 times of volume water distillations and collects volatile oil in 4 hours, and volatile oil is preserved in 4 ℃ of refrigerators.Medicinal residues and the Radix Rehmanniae, Radix Ophiopogonis, Flos Lonicerae are merged conventional the decoction.Bulbus Fritillariae Cirrhosae 70% alcohol reflux 4 hours reclaims behind the ethanol to mix with aforementioned decocting liquid and concentrates the back and add ethanol to 60% and leave standstill after 24 hours and concentrate, and sneaks into the volatile oil conduct next day and is subjected to test solution.
[experimental technique]
1. adopt Mus ear swelling method, 20 male mices are divided into administration group and matched group at random, and gastric infusion is irritated the long-pending 20ml/kg of being of body of stomach respectively, once a day, and continuous 6 days.Behind last filling stomach 1 hour, respectively be coated with dimethylbenzene 20 μ l in each group mouse right ear front-back same area with micropipettor respectively.Put to death animal after 4 hours, cut ears, lay round auricle at same position respectively with card punch.Scales/electronic balance weighing, the difference of auris dextra sheet and left auricle weight is the swelling degree, experimental result adopts SPSS 13.0 for windows One-Way ANOVA to carry out statistical disposition.Result such as following table:
Lung heat-cleaning throat-moistening cough-relieving syrup is to the antiinflammatory action of mice
Annotate: compare with matched group:
*P＜0.01
As seen compare with matched group, lung heat-cleaning throat-moistening cough-relieving syrup can significantly reduce the mice auricle swelling degree (P＜0.01) that dimethylbenzene causes, illustrates that this prescription has better antiinflammatory action.
2. adopt mice ammonia to draw the method for coughing.20 male and female mices half and half are divided into administration group and matched group at random, and gastric infusion is irritated the long-pending 20ml/kg of being of body of stomach respectively, once a day, and continuous 6 days.Behind last filling stomach 1 hour, mice is placed in the 1500ml glass bell jar, spray in the bell jar by soniclizer that (nebulizer atomization quantity and exhaust air rate all are made as 50%, and the spraying bore is 1cm * 1cm), continue spraying 5 seconds after with ammonia atomization equably by the bottom.Observe cough latent period (the spraying beginning is to the required time of cough takes place) and the cough number of times in 2 minutes of mice.The cough performance is shunk (breast contracts) with abdominal muscle, magnifies mouth simultaneously and is as the criterion.Experimental result adopts SPSS 13.0 for windows One-WayANOVA to carry out statistical disposition.Result such as following table:
Lung heat-cleaning throat-moistening cough-relieving syrup is to the antitussive effect of mice
Annotate: compare with matched group:
*P＜0.01
Compare with matched group as seen from the table, the administration group can significantly reduce the cough number of times (P＜0.01) that ammonia brings out mice, illustrates that this prescription has better antitussive effect.
Claims (4)
1, lung heat-cleaning throat-moistening cough-relieving syrup is characterized in that crude drug consists of: 6-12 parts in the Radix Rehmanniae, 9-15 parts of Radix Ophiopogonis, 9-15 parts of Bulbus Fritillariae Cirrhosaes, 7-13 parts of Herba Menthaes, 5-11 parts of Flos Loniceraes.
2, lung heat-cleaning throat-moistening cough-relieving syrup according to claim 1 is characterized in that crude drug consists of: Radix Rehmanniae 27g, Radix Ophiopogonis 36g, Bulbus Fritillariae Cirrhosae 36g, Herba Menthae 30g, Flos Lonicerae 24g.
3, lung heat-cleaning throat-moistening cough-relieving syrup according to claim 1 is characterized in that crude drug consists of: Radix Rehmanniae 18g, Radix Ophiopogonis 24g, Bulbus Fritillariae Cirrhosae 24g, Herba Menthae 20g, Flos Lonicerae 16g.
4, lung heat-cleaning throat-moistening cough-relieving syrup according to claim 1 is characterized in that crude drug consists of: Radix Rehmanniae 9g, Radix Ophiopogonis 12g, Bulbus Fritillariae Cirrhosae 12g, Herba Menthae 10g, Flos Lonicerae 8g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100471325A CN100512850C (en) | 2006-07-06 | 2006-07-06 | Lung heat-cleaning throat-moistening cough-relieving syrup |
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| CNB2006100471325A CN100512850C (en) | 2006-07-06 | 2006-07-06 | Lung heat-cleaning throat-moistening cough-relieving syrup |
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| CN100512850C true CN100512850C (en) | 2009-07-15 |
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| CNB2006100471325A Expired - Fee Related CN100512850C (en) | 2006-07-06 | 2006-07-06 | Lung heat-cleaning throat-moistening cough-relieving syrup |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104784569A (en) * | 2015-05-20 | 2015-07-22 | 庞兴伟 | Medicine for preventing and treating respiratory diseases of feline animals |
| CN105053776A (en) * | 2015-07-29 | 2015-11-18 | 李艳青 | Food therapy formula capable of stopping coughing and resolving phlegm and preparation method thereof |
| CN105079255A (en) * | 2015-09-17 | 2015-11-25 | 戚佳奉 | Mist spray for treating chronic bronchitis and preparation method thereof |
| CN105169079A (en) * | 2015-10-22 | 2015-12-23 | 丘勇番 | Sphagitis lozenge |
| CN106819736A (en) * | 2016-12-28 | 2017-06-13 | 黄晶晶 | A kind of removing heat from the lung and relieving sorethroat cough-relieving health drink |
| CN108653564A (en) * | 2018-07-30 | 2018-10-16 | 佛山科学技术学院 | A kind of Chinese medicine moistening lung and nourishing throat lozenge and preparation method thereof |
| CN113350465A (en) * | 2021-07-17 | 2021-09-07 | 韩山师范学院 | Sugar-free compound loquat leaf extract |
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2006
- 2006-07-06 CN CNB2006100471325A patent/CN100512850C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 中华人民共和国药典2000版一部. 国家药典委员会，537，化学工业出版社. 2000 |
| 中华人民共和国药典2000版一部. 国家药典委员会，537，化学工业出版社. 2000 * |
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