CN102429980A - Cold granules and preparation method thereof - Google Patents
Cold granules and preparation method thereof Download PDFInfo
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- CN102429980A CN102429980A CN2011104172287A CN201110417228A CN102429980A CN 102429980 A CN102429980 A CN 102429980A CN 2011104172287 A CN2011104172287 A CN 2011104172287A CN 201110417228 A CN201110417228 A CN 201110417228A CN 102429980 A CN102429980 A CN 102429980A
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Abstract
The invention relates to cold granules, and belongs to the technical field of Chinese medicines. The granules consist of the following raw materials by weight: 100 to 200g of ephedra herb, 50 to 100g of chrysanthemum, 100 to 200g of kudzuvine root, 100 to 200g of perilla leaf, 100 to 150g of cassia twig, 50 to 100g of weeping forsythia, 100 to 150g of liquoric root, 100 to 150g of tangerine peel, 100 to 200g of bitter apricot seed, 100 to 150g of platycodon root and 50 to 100g of indigowoad root. A preparation method comprises the following steps of: weighing the eleven raw materials, extracting volatile oil from the perilla leaf and the tangerine peel, decocting dregs, the ephedra herb, the chrysanthemum, the kudzuvine root, the cassia twig, the weeping forsythia, the liquoric root, the bitter apricot seed, the platycodon root and the indigowoad root in water for three times, mixing three-time decoction, filtering, concentrating filtrate to obtain clear paste with the relative density of 1.30 to 1.50, spray-drying, adding auxiliary materials for granules such as white sugar, dextrin and the like, uniformly mixing, pelletizing by using 75 percent ethanol, drying, spraying the extracted volatile oil, and uniformly mixing. The cold granules are convenient to take, act stably, have a definite curative effect, stable formulations and controllable quality, does not have any toxic or side effect, and can meet the requirement of patients.
Description
Technical field
The present invention relates to a kind of cold granules and preparation method thereof, be specifically related to a kind of compound recipe Common Cold granule and preparation method thereof, belong to the Chinese medicine production technical field.
Background technology
Flu is a kind of common respiratory system disease, and patient also is symptoms such as yellow, sore throat with heating, thick sputum except the general symptom that flu such as nasal obstruction, watery nasal discharge, cough, headache are arranged, usually in cold symptoms before just bitterly.The generation of flu is empty mainly due to body, and resistance against diseases weakens, and when weather drastic change, the inside and outside function of human body can not adapt to, and pathogen is taken advantage of a weak point in opponent's defence and gone into by fur, mouth and nose, causes that a series of lungs defend symptom.Cold partially person then causes pathogenic cold hampering the exterior, inhibited pulmonary QI, the strongly fragrant resistance of yang-energy, occlusion of the pores of skin; Partial heat person, the pathogenic heat lung that burns then, space between skin and muscles catharsis, impairment of purifying function of the lung.Though flu sees with ailment said due to cold or exposure more, different with season, press from both sides seasonal epidemic pathogens or the gas when non-more, as press from both sides wet, folder summer-heat etc.Anemofrigid cold: aversion to cold is heavy, and slight fever or do not generate heat is lossless, rhinocnesmus sneeze, and it is low voice speaking to have a stuffy nose, and coughs up clear and thin sputum, and limbs are miserable, white and thin fur, floating and tense pulse; Anemopyretic cold: micro evil wind is cold, and heating is heavy, and antiperspirant is arranged, the turbid tears of having a stuffy nose, and it is thick or yellow to cough up phlegm, and laryngopharynx swelling and pain is thirsty, yellow and thin fur, floating and rapid pulse; The wet then headache of folder is as wrapping up in, and is uncomfortable in chest indigestion and loss of appetite; Folder summer-heat is no relieving of symptom after perspiration then, restlessness and thirst.
The treatment flu should be principle with relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, but the medicine of treatment flu at present has many kinds, because Chinese patent medicine has little, the eutherapeutic characteristics of side effect; So receive people's favor; Clinical practice proves, and is improper if Chinese patent medicine is selected for use, but also delay treatment; The traditional Chinese medical science thinks that flu should be according to the principle of determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, and dissimilar flu should be selected the different drug treatment for use.Mostly the medicine of treatment flu at present is Western medicine and antibiotics, and side effect is more common, and the serious adverse effects in addition that has is though have better antipyretic, analgesic activity; But usually can cause untoward reaction, like gastrointestinal upset, allergic dermatitis, the medicine that has also can cause drowsiness; And the uncertain therapeutic efficacy of antibiotics treatment flu is fixed, and is prone to cause Resistant strain generation and dysbacteriosis, anaphylaxis etc.; Chinese patent drugs for treatment flu determined curative effect is generally acknowledged that in recent years, the Chinese medicine of treatment flu occurs in a large number on the market; Some belongs to cures the symptoms, not the disease, and some uses price comparison expensive, and some interrupts use because uncertain therapeutic efficacy is cut in application process; The sugar content of some Chinese patent medicines is big, and each taking dose is big, and dissolubility is relatively poor.So study a kind of taking convenience, effect steadily, determined curative effect, dosage form is stable, the pure Chinese medicinal preparation of the quality controllable and treatment flu that has no side effect has great significance with the demand that satisfies extensive patients.
Summary of the invention
The purpose of this invention is to provide a kind of cold granules, this granule effect is steady, determined curative effect, and dosage form is stable, can satisfy patient's demand.
In order to address the above problem, the technical scheme that the present invention adopted is:
A kind of cold granules, form by the component of following weight:
Herba Ephedrae 100 ~ 200g, Flos Chrysanthemi 50 ~ 100g, Radix Puerariae 100 ~ 200g, Folium Perillae 100 ~ 200g, Ramulus Cinnamomi 100 ~ 150g, Fructus Forsythiae 50 ~ 100g, Radix Glycyrrhizae 100 ~ 150g, Pericarpium Citri Reticulatae 100 ~ 150g, Semen Armeniacae Amarum 100 ~ 200g, Radix Platycodonis 100 ~ 150g, Radix Isatidis 50 ~ 100g;
Its optimization formula is:
Herba Ephedrae 100g, Flos Chrysanthemi 75g, Radix Puerariae 100g, Folium Perillae 150g, Ramulus Cinnamomi 100g, Fructus Forsythiae 100g, Radix Glycyrrhizae 100g, Pericarpium Citri Reticulatae 100g, Semen Armeniacae Amarum 100g, Radix Platycodonis 100g, Radix Isatidis 100g.
More than ten simply, Folium Perillae and Pericarpium Citri Reticulatae extract volatile oil, volatile oil is subsequent use, medicinal residues after the extraction and Herba Ephedrae, Flos Chrysanthemi, Radix Puerariae, Ramulus Cinnamomi, Fructus Forsythiae, Radix Glycyrrhizae, Semen Armeniacae Amarum, Radix Platycodonis, Radix Isatidis decocte with water three times; 2 ~ 3 hours for the first time, 1 ~ 2 hour for the second time, 0.5 ~ 1 hour for the third time, merges the decocting liquid of three decoctions; Filter, it is 1.30 ~ 1.50 clear paste that filtrating is concentrated into relative density, spray drying; Press granules such as convention amount adding white sugar and dextrin and use adjuvant, mixing is with 75% alcohol granulation; Spray into after the drying extract volatile oil, mixing promptly gets.
The present invention with respect to the beneficial effect of prior art is:
Cold granules agent taking convenience of the present invention, effect steadily, determined curative effect, dosage form is stable, and is quality controllable and have no side effect, and can satisfy patient's demand.
The usage and dosage of this Chinese medicine is oral, one time 1 bag, 3 times on the one.
The specific embodiment
Through embodiment the present invention is explained further details below, these embodiment only are used for explaining the present invention, do not limit the scope of the invention.
Embodiment 1
Herba Ephedrae 100g, Flos Chrysanthemi 50g, Radix Puerariae 100g, Folium Perillae 100g, Ramulus Cinnamomi 100g, Fructus Forsythiae 50g, Radix Glycyrrhizae 100g, Pericarpium Citri Reticulatae 100g, Semen Armeniacae Amarum 100g, Radix Platycodonis 100g, Radix Isatidis 50g;
More than ten simply, Folium Perillae and Pericarpium Citri Reticulatae extract volatile oil, volatile oil is subsequent use, medicinal residues after the extraction and Herba Ephedrae, Flos Chrysanthemi, Radix Puerariae, Ramulus Cinnamomi, Fructus Forsythiae, Radix Glycyrrhizae, Semen Armeniacae Amarum, Radix Platycodonis, Radix Isatidis decocte with water three times; 2 hours for the first time, 1 hour for the second time, 0.5 hour for the third time, merges the decocting liquid of three decoctions; Filter, it is 1.30 clear paste that filtrating is concentrated into relative density, spray drying; Press granules such as convention amount adding white sugar and dextrin and use adjuvant, mixing is with 75% alcohol granulation; Spray into after the drying extract volatile oil, mixing promptly gets.
Embodiment 2
Herba Ephedrae 200g, Flos Chrysanthemi 100g, Radix Puerariae 200g, Folium Perillae 200g, Ramulus Cinnamomi 150g, Fructus Forsythiae 100g, Radix Glycyrrhizae 150g, Pericarpium Citri Reticulatae 150g, Semen Armeniacae Amarum 200g, Radix Platycodonis 150g, Radix Isatidis 100g;
More than ten simply, Folium Perillae and Pericarpium Citri Reticulatae extract volatile oil, volatile oil is subsequent use, medicinal residues after the extraction and Herba Ephedrae, Flos Chrysanthemi, Radix Puerariae, Ramulus Cinnamomi, Fructus Forsythiae, Radix Glycyrrhizae, Semen Armeniacae Amarum, Radix Platycodonis, Radix Isatidis decocte with water three times; 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, merges the decocting liquid of three decoctions; Filter, it is 1.50 clear paste that filtrating is concentrated into relative density, spray drying; Press granules such as convention amount adding white sugar and dextrin and use adjuvant, mixing is with 75% alcohol granulation; Spray into after the drying extract volatile oil, mixing promptly gets.
Embodiment 3
Herba Ephedrae 150g, Flos Chrysanthemi 75g, Radix Puerariae 150g, Folium Perillae 150g, Ramulus Cinnamomi 125g, Fructus Forsythiae 75g, Radix Glycyrrhizae 125g, Pericarpium Citri Reticulatae 125g, Semen Armeniacae Amarum 150g, Radix Platycodonis 125g, Radix Isatidis 75g;
More than ten simply, Folium Perillae and Pericarpium Citri Reticulatae extract volatile oil, volatile oil is subsequent use, medicinal residues after the extraction and Herba Ephedrae, Flos Chrysanthemi, Radix Puerariae, Ramulus Cinnamomi, Fructus Forsythiae, Radix Glycyrrhizae, Semen Armeniacae Amarum, Radix Platycodonis, Radix Isatidis decocte with water three times; 2.5 hours for the first time, 1.5 hours for the second time, 0.5 hour for the third time, merges the decocting liquid of three decoctions; Filter, it is 1.40 clear paste that filtrating is concentrated into relative density, spray drying; Press granules such as convention amount adding white sugar and dextrin and use adjuvant, mixing is with 75% alcohol granulation; Spray into after the drying extract volatile oil, mixing promptly gets.
Embodiment 4
Herba Ephedrae 100g, Flos Chrysanthemi 50g, Radix Puerariae 100g, Folium Perillae 100g, Ramulus Cinnamomi 150g, Fructus Forsythiae 100g, Radix Glycyrrhizae 150g, Pericarpium Citri Reticulatae 150g, Semen Armeniacae Amarum 200g, Radix Platycodonis 150g, Radix Isatidis 100g;
More than ten simply, Folium Perillae and Pericarpium Citri Reticulatae extract volatile oil, volatile oil is subsequent use, medicinal residues after the extraction and Herba Ephedrae, Flos Chrysanthemi, Radix Puerariae, Ramulus Cinnamomi, Fructus Forsythiae, Radix Glycyrrhizae, Semen Armeniacae Amarum, Radix Platycodonis, Radix Isatidis decocte with water three times; 2 hours for the first time, 1 hour for the second time, 0.5 hour for the third time, merges the decocting liquid of three decoctions; Filter, it is 1.35 clear paste that filtrating is concentrated into relative density, spray drying; Press granules such as convention amount adding white sugar and dextrin and use adjuvant, mixing is with 75% alcohol granulation; Spray into after the drying extract volatile oil, mixing promptly gets.
Embodiment 5
Herba Ephedrae 100g, Flos Chrysanthemi 75g, Radix Puerariae 100g, Folium Perillae 150g, Ramulus Cinnamomi 100g, Fructus Forsythiae 100g, Radix Glycyrrhizae 100g, Pericarpium Citri Reticulatae 100g, Semen Armeniacae Amarum 100g, Radix Platycodonis 100g, Radix Isatidis 100g.
More than ten simply, Folium Perillae and Pericarpium Citri Reticulatae extract volatile oil, volatile oil is subsequent use, medicinal residues after the extraction and Herba Ephedrae, Flos Chrysanthemi, Radix Puerariae, Ramulus Cinnamomi, Fructus Forsythiae, Radix Glycyrrhizae, Semen Armeniacae Amarum, Radix Platycodonis, Radix Isatidis decocte with water three times; 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, merges the decocting liquid of three decoctions; Filter, it is 1.50 clear paste that filtrating is concentrated into relative density, spray drying; Press granules such as convention amount adding white sugar and dextrin and use adjuvant, mixing is with 75% alcohol granulation; Spray into after the drying extract volatile oil, mixing promptly gets.
Claims (3)
1. cold granules, it is characterized in that: the component by following weight is formed:
Herba Ephedrae 100 ~ 200g, Flos Chrysanthemi 50 ~ 100g, Radix Puerariae 100 ~ 200g, Folium Perillae 100 ~ 200g, Ramulus Cinnamomi 100 ~ 150g, Fructus Forsythiae 50 ~ 100g, Radix Glycyrrhizae 100 ~ 150g, Pericarpium Citri Reticulatae 100 ~ 150g, Semen Armeniacae Amarum 100 ~ 200g, Radix Platycodonis 100 ~ 150g, Radix Isatidis 50 ~ 100g.
2. a kind of cold granules according to claim 1 is characterized in that: the component by following weight is formed:
Herba Ephedrae 100g, Flos Chrysanthemi 75g, Radix Puerariae 100g, Folium Perillae 150g, Ramulus Cinnamomi 100g, Fructus Forsythiae 100g, Radix Glycyrrhizae 100g, Pericarpium Citri Reticulatae 100g, Semen Armeniacae Amarum 100g, Radix Platycodonis 100g, Radix Isatidis 100g.
3. a method that is used to prepare claim 1 or 2 described cold granules is characterized in that: comprise the steps:
More than ten simply, Folium Perillae and Pericarpium Citri Reticulatae extract volatile oil, volatile oil is subsequent use, medicinal residues after the extraction and Herba Ephedrae, Flos Chrysanthemi, Radix Puerariae, Ramulus Cinnamomi, Fructus Forsythiae, Radix Glycyrrhizae, Semen Armeniacae Amarum, Radix Platycodonis, Radix Isatidis decocte with water three times; 2 ~ 3 hours for the first time, 1 ~ 2 hour for the second time, 0.5 ~ 1 hour for the third time, merges the decocting liquid of three decoctions; Filter, it is 1.30 ~ 1.50 clear paste that filtrating is concentrated into relative density, spray drying; Press convention amount and add white sugar and dextrin adjuvant, mixing is with 75% alcohol granulation; Spray into after the drying extract volatile oil, mixing promptly gets.
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| CN2011104172287A CN102429980A (en) | 2011-12-14 | 2011-12-14 | Cold granules and preparation method thereof |
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| CN2011104172287A CN102429980A (en) | 2011-12-14 | 2011-12-14 | Cold granules and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106334040A (en) * | 2016-08-31 | 2017-01-18 | 安徽省润生医药股份有限公司 | Medicinal composition for treating wind-heat type common cold, preparation method thereof and preparation |
| CN107441177A (en) * | 2017-08-17 | 2017-12-08 | 佛山推启农业研究院（普通合伙） | A kind of tea for common cold and preparation method thereof |
| CN109289032A (en) * | 2018-12-12 | 2019-02-01 | 怀化正好制药有限公司 | Wind-solar resources and its preparation process |
-
2011
- 2011-12-14 CN CN2011104172287A patent/CN102429980A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106334040A (en) * | 2016-08-31 | 2017-01-18 | 安徽省润生医药股份有限公司 | Medicinal composition for treating wind-heat type common cold, preparation method thereof and preparation |
| CN107441177A (en) * | 2017-08-17 | 2017-12-08 | 佛山推启农业研究院（普通合伙） | A kind of tea for common cold and preparation method thereof |
| CN109289032A (en) * | 2018-12-12 | 2019-02-01 | 怀化正好制药有限公司 | Wind-solar resources and its preparation process |
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Application publication date: 20120502 |