CN103768429A - Traditional Chinese medicinal composition for treating acute and chronic pharyngitis and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for treating acute and chronic pharyngitis and preparation method thereof Download PDFInfo
- Publication number
- CN103768429A CN103768429A CN201310739329.5A CN201310739329A CN103768429A CN 103768429 A CN103768429 A CN 103768429A CN 201310739329 A CN201310739329 A CN 201310739329A CN 103768429 A CN103768429 A CN 103768429A
- Authority
- CN
- China
- Prior art keywords
- radix
- parts
- chinese medicine
- acute
- chronic pharyngitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicinal composition for treating acute and chronic pharyngitis and a preparation method thereof. The composition is prepared from the following raw materials: honeysuckle, isatis root, platycodon grandiflorum, radix scrophulariae, puffball, oroxylum indicum vent, rhizoma nelumbinis, radix ophiopogonis, chrysanthemum, mint, raw rehmannia, couch grass root and liquorice. The invention also provides the preparation method of the traditional Chinese medicinal composition for treating acute and chronic pharyngitis. The traditional Chinese medicinal composition for treating acute and chronic pharyngitis is exact in curative effect and good in safety, and does not have side effect.
Description
Technical field
The present invention relates to pharmaceutical sanitary field, be specifically related to a kind of Chinese medicine composition for the treatment of acute/chronic pharyngitis and preparation method thereof.Background technology
Acute/chronic pharyngitis mainly refers under pharyngeal mucosa, mucosa and adenoid diffuse inflammation, often with other upper respiratory disease, is a kind of disease of pharynx very common in crowd.Clinical symptoms is mainly take the congestion and swelling pain of bottleneck throat, do not feel like oneself as disease while swallowing, abundant expectoration is mucofilin not, speech fatiguability, or gargle in brushing teeth, the easy nausea and vomiting when many of talking, majority is also with General Symptomies such as upper respiratory tract infection symptoms and inappetence such as heating, coughs.Chronic pharyngitis is many because acute pharyngitis repeatedly shows effect or treat not thoroughly, and the stimulation of adjacent organs focus causes as sinusitis, tonsillitis, nasopharyngitis, tracheitis etc.Tobacco and wine excessively, dust and harmful gas stimulate for commonly encountered diseases because of.
Acute/chronic pharyngitis is commonly encountered diseases, frequently-occurring disease, particularly social worker clinically, and brain worker's accounting example is more, all can occur throughout the year, and it gives daily life and the healthy a lot of misery and inconvenient of having brought.
The method for the treatment of pharyngitis has at present: operative treatment, local injection treatment, the hormone therapy of Western medicine antibiotic, Chinese patent medicine buccal tablets etc.Operation and local injection treatment make that patient trauma is large, misery is many, and medical expense is high, and general patient is not able to beyond affordability less than ten thousand, and western medicine side effect is large, and cures the symptoms, not the disease and can not effect a radical cure.
The traditional Chinese medical science is generally divided following several to acute pharyngitis: 1, affection by exopathogenic cold-wind.Suitable expelling wind and cold, lung qi dispersing sore-throat relieving.Common medicine: Herba Schizonepetae, Radix Saposhnikoviae, Herba Menthae, Bombyx Batryticatus, Radix Platycodonis etc.2, wind heat is attacked outward.Suitable wind and heat dispersing, relieving sore throat and diminishing swelling.Common medicine: Flos Lonicerae, Fructus Forsythiae, Fructus Arctii, Herba Schizonepetae, Folium Bambusae etc.3, lung sthenia gastropyrexia.The removing toxic substances that should expel the heat-evil, detumescence sore-throat relieving.Common medicine: Radix Scutellariae, Rhizoma Coptidis, Radix Sophorae Tonkinensis, Lasiosphaera Seu Calvatia, Rhizoma Belamcandae, Radix Trichosanthis etc.In addition Chinese patent medicine Compound Sijiqing Tablets has the effect of heat-clearing and toxic substances removing, detumescence pharynx, and virus and antibacterial are had to coordinating effect.Other treatment also has Chinese medicine rinsing the mouth, buccal and the insufflation of powder drug.
Prophylaxis of acute pharyngitis should avoid surfeit pungent, scorch food, polyphagia vegetable and fruit, smoking cessation, drinks etc. less; Active treatment flu, control adjacent organs disease, as rhinitis, tonsillitis etc.; Improve environment, reduce air pollution, strengthen Personal hygiene protection.
Due to pharyngitis very easily repeatedly, treat at present Chinese patent medicine and the various decoction of pharyngitis, take effect slow or treatment is thorough not, need provide a kind of curative effect better medicine symptomatic treatment acute/chronic pharyngitis.
Just symptomatic treatment, administration time is long, and dose is large, also has certain curative effect although be free from side effects, and also just reaches alleviation disease, is difficult for radical cure.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of acute/chronic pharyngitis;
Another object of the present invention is to provide a kind of Chinese medicine composition preparation method for the treatment of acute/chronic pharyngitis.
The object of the invention is to realize by following technical scheme:
The Chinese medicine composition for the treatment of acute/chronic pharyngitis of the present invention is to be prepared from by the raw material containing following weight portion:
Flos Lonicerae 11-20 part, Radix Isatidis 11-20 part, Radix Platycodonis 5-14 part, Radix Scrophulariae 5-14 part, Lasiosphaera Seu Calvatia 3-8 part, Semen Oroxyli 3-8 part, Nodus Nelumbinis Rhizomatis 5-14 part, Radix Ophiopogonis 5-14 part, Flos Chrysanthemi 5-14 part, Herba Menthae 3-8 part, Radix Rehmanniae 5-14 part, Rhizoma Imperatae 5-14 part, Radix Glycyrrhizae 3-8 part.
Preferably, be to be prepared from by the raw material containing following weight portion:
Flos Lonicerae 13-17 part, Radix Isatidis 13-17 part, Radix Platycodonis 8-12 part, Radix Scrophulariae 8-12 part, Lasiosphaera Seu Calvatia 5-7 part, Semen Oroxyli 5-7 part, Nodus Nelumbinis Rhizomatis 8-12 part, Radix Ophiopogonis 8-12 part, Flos Chrysanthemi 8-12 part, Herba Menthae 5-7 part, Radix Rehmanniae 8-12 part, Rhizoma Imperatae 8-12 part, Radix Glycyrrhizae 5-7 part.
More preferably, be to be prepared from by the raw material containing following weight portion:
15 parts of Flos Loniceraes, 15 parts of Radix Isatidis, 10 parts of Radix Platycodoniss, 10 parts of Radix Scrophulariaes, 6 parts of Lasiosphaera Seu Calvatia, 6 parts of Semen Oroxylis, 10 parts of Nodus Nelumbinis Rhizomatis, 10 parts of Radix Ophiopogonis, 10 parts of Flos Chrysanthemis, 6 parts of Herba Menthaes, 10 parts, the Radix Rehmanniae, 10 parts of Rhizoma Imperataes, 6 parts, Radix Glycyrrhizae.
Below crude drug source of the present invention:
Flos Lonicerae: formal name used at school Radix Ophiopogonis (Lonicera japonica Thunb.) is the perennial half evergreen liana of Caprifoliaceae.Sweet in flavor and cold in property, return lung, the heart, stomach warp.Effect is heat-clearing and toxic substances removing, dispelling wind and heat pathogens.Compendium of Material Medica is recorded, and it can be used for " all rheumatism gas, and all toxic swellings, carbuncle Jie Xian, all malignant boil of Fructus Myricae rubrae.Heat radiation removing toxic substances ".Its modern pharmacology effect shows to have broad-spectrum antibacterial action, especially so that staphylococcus aureus, dysentery bacterium are had to stronger inhibitory action.In addition, promote in addition leukocytic phagocytosis, and obvious antiinflammatory and refrigeration function.
Radix Isatidis: Radix Isatidis is divided into northern Radix Isatidis and Rhizoma Et Radix Baphicacanthis Cusiae, the root that northern Radix Isatidis source is cruciferae isatis (Isatis tinctoria L.) and careless Folium Isatidis (I.indigotica Fort.); Rhizoma Et Radix Baphicacanthis Cusiae is rhizome and the root of acanthaceous vegetable acanthaceous indigo (Baphicacanthus cusia (Nees) Brem.).In we, be all monarch with Flos Lonicerae and want, its property of medicine bitter cold, GUIXIN, stomach warp.Have heat-clearing and toxic substances removing, the function of removing heat from blood sore-throat relieving, is used for fever caused by exogenous pathogens, and epidemic febrile disease is from the beginning of, laryngopharynx swelling and pain.Modern pharmacological research shows, it has inhibitory action, improving immunocompetence to multiple Glan positive bacteria and negative bacterium and influenza virus etc.
Radix Platycodonis: bellwort Platycodon grandiflouorum Platycodon grandiflorus.Nature and flavor toil is flat, returns lung meridian.Effect lung qi dispersing eliminates the phlegm, sore-throat relieving evacuation of pus." it is with having four, and only pharyngalgia, holds concurrently except nasal obstruction for nature of the Drugs of the Peal Bag in Songs cloud; Profit trapping, can control lung abscess; One is the ships of all medicines, the tying-in that is pulmonary ".Modern pharmacology effect shows that Radix Platycodonis glycosides energy reflexive ground causes bronchial mucosa hypersecretion, thereby makes sputum dilution, the depressed eliminating; Radix Platycodonis also has antitussive, strengthens antiinflammatory and immunization.
Radix Scrophulariae: Scrophulariaceae Scrophularia Scrophularia ningpoensis.Nature and flavor sweetness and bitterness is salty, returns lung, stomach, kidney channel.Can clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing eliminating stagnation.When treatment pharyngalgia, diphtheria, many and Radix Isatidis compatibility, while treating carbuncle sore tumefacting virus can with Flos Lonicerae compatibility, its eliminating fire and detoxication power is strong, therefore laryngopharynx swelling and pain, phlegm-fire scrofula is multiplex.This product pharmacological research all has inhibitory action to staphylococcus aureus, diphtheria corynebacterium, Bacillus typhi, bacillus pyocyaneus etc., goes back Anhydroalkannin simultaneously, antipyretic, convulsion.
Lasiosphaera Seu Calvatia: belong to basidiomycetes Lycoperdaceae LASIOSPHAERA SEU CALVATIA.Nature and flavor are pungent flat, return lung meridian.Can heat-clearing and toxic substances removing, sore-throat relieving hemostasis.Lasiosphaera Seu Calvatia light weight, belongs to part of the body cavity above the diaphragm housing the heart and lungs lung meridian medicine also, therefore for clearing away lung-heat cough, sore throat, aphonia.It all has machining function to staphylococcus aureus, bacillus pyocyaneus, Bacillus proteus and Diplococcus pneumoniae.
Semen Oroxyli: belong to Bignoniaceae Semen Oroxyli (Oroxylum indicum), have another name called Oroxylum indicum.Property bitter but sweet flavor is cool, returns lung, liver, stomach warp.Effect removing heat from the lung and relieving sorethroat, dispersing the stagnated liver-QI for regulating the stomach.Treatment laryngopharynx swelling and pain common medicine, removing heat from the lung and dissipating phlegm and Radix Platycodonis compatibility, treatment pathogenic heat damaging YIN, laryngopharynx swelling and pain, hoarseness often and Radix Scrophulariae, Radix Ophiopogonis compatibility.
Nodus Nelumbinis Rhizomatis: be the loose rhizome of nymphaeaceae plant lotus Nelumbo nucifera G..Property sweet-puckery flavor flat, return liver, lung, stomach warp, function astringing to arrest bleeding.
Radix Ophiopogonis: be Liliaceae Ophiopogon plant Radix Ophiopogonis (Ophitopogin japonicus(L.f) Ker.-Gawl.) be used as medicine with tuber.Sweet, the micro-hardship of nature and flavor, be slightly cold, return stomach, lung, heart channel.There is nourishing YIN and moistening the lung, reinforcing stomach reg fluid, relieving restlessness function clears away heart-fire.The kind lung yin of supporting of this product, clearing away lung-heat, being applicable to lung-dryness syndrome due to deficiency of YIN has hot dryness in the nasal cavity dry pharynx, the few expectorant of dry cough, hemoptysis, the diseases such as pharyngalgia hoarseness.It has rising peripheral leukocytes, improves immunologic function, also has certain calmness and antibacterial action.
Flos Chrysanthemi: formal name used at school Dendranthema morifolium, conventional chrysanthemum, Compositae, Chrysanthemum.The pungent sweetness and bitterness of nature and flavor, is slightly cold, and returns lung, Liver Channel.There is dispelling wind and heat pathogens, suppressing liver-YANG, liver heat removing and eyesight improving, antipyretic and antidote functions.Its water logging agent or decoct, have certain antibacterial action to staphylococcus aureus, multiple Xenorhabdus, and its preparation has coronary artery dilator, increases coronary flow, improves the effect of myocardial oxygen consumption, and have antipyretic, antiinflammatory, sedation.
Herba Menthae: the mint Herba Menthae Mentha haplocalyx Briq. of Herba lamii barbati subfamily Ta Hua family.Pungent in flavor and cool in property, return lung, Liver Channel.Effect dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, soothing the liver circulation of qi promoting.This product lightly floats to rise and floats, awakening consciousness, kind part of the body cavity above the diaphragm housing the heart and lungs wind heat, refresh oneself, the throat evacuated of merit.Its Oleum menthae composition can make trachea produce new secretions, makes the mucus of stiff be easy to discharge, thus can eliminate the phlegm, and have good antitussive action.Experiment in vitro shows that it all has inhibitory action to staphylococcus aureus, alpha streptococcus, group B streptococcus, diphtheria corynebacterium, bacillus pyocyaneus etc.
The Radix Rehmanniae: the fresh or dry tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch..Nature and flavor sweetness and bitterness is cold, GUIXIN, liver, kidney channel.Effect clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.Its water extraction liquid has blood pressure lowering, calmness, antiinflammatory, anti-allergic effects.
Rhizoma Imperatae: have another name called Rhizoma Imperatae, Rhizoma Imperatae, Rhizoma Imperatae, for grass family Rhizoma Imperatae belongs to herbaceos perennial.Sweet in flavor and cold in property, return lung, stomach, urinary bladder channel.There is cooling blood for hemostasis, clearing away heat and promoting diuresis, the function of lung heat clearing gastric heat.Its water decoction has inhibitory action to streptococcus pneumoniae, micrococcus catarrhalis, hemophilus influenza, staphylococcus aureus etc.
Radix Glycyrrhizae: be dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensisFisch., Glycyrrhiza inflata Bat. G.inflataBat., or the root and rhizome of Glycyrrhiza glabra L. G.glabraL..Nature and flavor are sweet flat, GUIXIN, lung, spleen, stomach warp.Effect invigorating the spleen and replenishing QI, expelling phlegm for arresting cough, relieving spasm to stop pain, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.
Another aspect of the present invention has been to provide the preparation method of the active component of Chinese medicine composition of the present invention, and the method is the ethanol extraction that adopts water extraction or 40-80% concentration expressed in percentage by volume.Concrete preparation method is as follows:
Scheme one: whole 12 taste medical materials except Herba Menthae, extracting in water 2-3 time, each amount of water is equivalent to 8-10 times of medical material gross weight, and each extraction time is 1-3 hour, and merge extractive liquid, filters, and filtrate is condensed into 3-4 times of medical material gross weight; Get Herba Menthae, add 6-8 times of water extraction 0.3-1 hour of medical material weight, filter, filtrate and above-mentioned concentrated solution merge, and obtain active component.
Scheme one is preferably: whole 12 taste medical materials except Herba Menthae, and extracting in water 3 times, each amount of water is equivalent to 8-10 times of medical material gross weight, and each extraction time is 1-2 hour, and merge extractive liquid, filters, and filtrate is condensed into 3 times of medical material gross weight; Get Herba Menthae, add 6-8 times of water extraction 0.3-0.5 hour of medical material weight, filter, filtrate and above-mentioned concentrated solution merge, and obtain active component.
Scheme two: get whole 13 taste medical materials, use 40-80% alcohol reflux 2-3 time, doubly, extraction time is 1-3 hour to the 4-10 that each ethanol consumption is medical material total amount, and merge extractive liquid,, filters, and filtrate is condensed into fluid extract, obtains active component.
The Chinese medicine composition for the treatment of acute/chronic pharyngitis of the present invention, can coordinate with pharmaceutically acceptable carrier, makes various common dosage forms, as tablet, granule, capsule, syrup etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.
Correctives: sucrose, monosaccharide, aromatic etc.
Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.
Method 1: tablet
Get scheme one to one of scheme three gained active component, add tablet to commonly use adjuvant, production method is prepared into tablet of the present invention routinely.
The conventional adjuvant of above-mentioned tablet comprises one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 2: granule
Get scheme one to one of scheme three gained active component, add granule to commonly use adjuvant, production method is prepared into granule of the present invention routinely.
The conventional adjuvant of above-mentioned granule comprises one of diluent, wetting agent, binding agent, disintegrating agent or whole.
Method 3: capsule
Get scheme one to one of scheme three gained active component, add capsule to commonly use adjuvant, production method is prepared into capsule of the present invention routinely.
The conventional adjuvant of above-mentioned capsule comprises one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 4: syrup
Get scheme one to one of scheme three gained active component, add syrup to commonly use adjuvant, production method is prepared into syrup of the present invention routinely.
The conventional adjuvant of above-mentioned syrup comprises one of correctives, antiseptic, cosolvent or whole.
Method 5: mixture
Get scheme one to one of scheme three gained active component, add mixture to commonly use adjuvant, production method is prepared into mixture of the present invention routinely.
The conventional adjuvant of above-mentioned mixture comprises one of correctives, antiseptic or whole.
According to theory of Chinese medical science, pharyngitis is generally divided into three kinds: affection by exopathogenic cold-wind, wind heat are attacked outward, lung sthenia gastropyrexia.The acute/chronic pharyngitis that wind heat is attacked outward, needs clearing away heat and expelling pathogen in the exterior, evacuates heat-phlegm.The applicant on the basis of research tradition tcm syndrome differentiation and treatment with reference to modern pharmacological research achievement, and in conjunction with the test through for many years, multiple formulations is screened, and having found cooperatively interacts attacks type acute/chronic pharyngitis outward to wind heat and has the Chinese medicine composition of better therapeutic effect down.
In we, take Flos Lonicerae and Radix Isatidis as monarch drug, get its heat-clearing and toxic substances removing; Minister is with Radix Platycodonis, Radix Scrophulariae, Lasiosphaera Seu Calvatia, Semen Oroxyli, Nodus Nelumbinis Rhizomatis, Radix Ophiopogonis, with lung qi dispersing, YIN nourishing, sore-throat relieving, cooling blood for hemostasis again; Assistant is with Flos Chrysanthemi, Herba Menthae, the Radix Rehmanniae, Rhizoma Imperatae, and principal drug assistance is evacuated wind heat, the removing pathogenic heat from blood and toxic substance from the body of the part of the body cavity above the diaphragm housing the heart and lungs; Finally with Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.All medicines share by opening lung qi dispersing gas, the fur of removing heat by catharsis, and relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, reach the merit of heat-clearing and toxic substances removing, removing heat from blood YIN nourishing, sore-throat relieving antiinflammatory.
Technical solution of the present invention meets the mechanism of tcm treatment according to syndrome differentiation, bases oneself upon the origin of disease, reasonable recipe science.
A kind of Chinese medicine composition for the treatment of acute/chronic pharyngitis provided by the invention has the following advantages
1, compositions provided by the invention and safe and effective, has effect of heat-clearing and toxic substances removing, lung qi dispersing YIN nourishing, sore-throat relieving antiinflammatory, and wind heat is attacked to type acute/chronic pharyngitis outward better therapeutic effect.
2, the present invention is through clinical verification, and acute pharyngitis cure-remarkable-effectiveness rate is 50.8%, and total effective rate is 93.2%; Chronic pharyngitis cure-remarkable-effectiveness rate is 63.6%, and total effective rate is 88.6%.Drug therapy wind heat of the present invention is attacked inside and outside double controlling of type acute/chronic pharyngitis outward, and recovery from illness thoroughly.
3, each ingredients distinct characteristics in the present invention has synergism simultaneously, can fundamentally cure acute/chronic pharyngitis.
The specific embodiment
Further illustrate the present invention below by embodiment.It should be understood that embodiments of the invention are for the present invention rather than limitation of the present invention are described.The simple modifications that essence according to the present invention is carried out the present invention all belongs to the scope of protection of present invention.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.
Embodiment 1 decoction
Extracting honeysuckle 15g, Radix Isatidis 15g, Radix Platycodonis 10g, Radix Scrophulariae 10g, Lasiosphaera Seu Calvatia 6g, Semen Oroxyli 6g, Nodus Nelumbinis Rhizomatis 10g, Radix Ophiopogonis 10g, Flos Chrysanthemi 10g, Herba Menthae 6g, Radix Rehmanniae 10g, Rhizoma Imperatae 10g, Radix Glycyrrhizae 6g.Whole 12 taste medical materials except Herba Menthae, extracting in water 3 times, each amount of water is equivalent to respectively 10 times, 8 times, 8 times of medical material gross weight, each extraction time is respectively 3 hours, 2 hours, 1 hour, merge extractive liquid,, filters, and filtrate is condensed into 3 times of medical material gross weight; Get Herba Menthae, add 8 times of water extraction 0.5 hour of medical material weight, filter, filtrate and the merging of above-mentioned concentrated solution, mix, and obtains decoction of the present invention.
Embodiment 2 syrups
Extracting honeysuckle 13g, Radix Isatidis 20g, Radix Platycodonis 8g, Radix Scrophulariae 5g, Lasiosphaera Seu Calvatia 12g, Semen Oroxyli 7g, Nodus Nelumbinis Rhizomatis 14g, Radix Ophiopogonis 12g, Flos Chrysanthemi 5g, Herba Menthae 6g, Radix Rehmanniae 5g, Rhizoma Imperatae 10g, Radix Glycyrrhizae 7g.Whole 12 taste medical materials except Herba Menthae, extracting in water 2 times, each amount of water is equivalent to respectively 10 times, 8 times of medical material gross weight, and each extraction time is respectively 3 hours, 2 hours, and merge extractive liquid, filters, and filtrate is condensed into 4 times of medical material gross weight; Get Herba Menthae, add 6 times of water extraction 0.3 hour of medical material weight, filter, filtrate and the merging of above-mentioned concentrated solution, add sucrose, sorbic acid, water to stir, and makes syrup.
Embodiment 3 tablets
Extracting honeysuckle 13g, Radix Isatidis 13g, Radix Platycodonis 8g, Radix Scrophulariae 8g, Lasiosphaera Seu Calvatia 5g, Semen Oroxyli 5g, Nodus Nelumbinis Rhizomatis 8g, Radix Ophiopogonis 8g, Flos Chrysanthemi 8g, Herba Menthae 5g, Radix Rehmanniae 8g, Rhizoma Imperatae 8g, Radix Glycyrrhizae 5g.Whole 12 taste medical materials except Herba Menthae, extracting in water 3 times, each amount of water is equivalent to respectively 10 times, 10 times, 8 times of medical material gross weight, each extraction time is respectively 2 hours, 1 hour, 1 hour, merge extractive liquid,, filters, and filtrate is condensed into 3.5 times of medical material gross weight; Get Herba Menthae, add 7 times of water extraction 1 hour of medical material weight, filter, filtrate and the merging of above-mentioned concentrated solution, mix, and adds supplementary product starch, ethanol, Pulvis Talci, makes tablet.
Embodiment 4 mixture
Extracting honeysuckle 17g, Radix Isatidis 17g, Radix Platycodonis 12g, Radix Scrophulariae 12g, Lasiosphaera Seu Calvatia 7g, Semen Oroxyli 7g, Nodus Nelumbinis Rhizomatis 12g, Radix Ophiopogonis 12g, Flos Chrysanthemi 12g, Herba Menthae 7g, Radix Rehmanniae 12g, Rhizoma Imperatae 12g, Radix Glycyrrhizae 7g.By above-mentioned whole medical materials alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, and each extraction time is respectively 3 hours, 2 hours, merge extractive liquid,, filter, filtrate is condensed into fluid extract, adds supplementary product starch, ethanol, Pulvis Talci, and adding purified water ad pond om is 3 times of medical material gross weight, fill, obtains mixture of the present invention.
Embodiment 5 tablets
Extracting honeysuckle 11g, Radix Isatidis 11g, Radix Platycodonis 5g, Radix Scrophulariae 5g, Lasiosphaera Seu Calvatia 3g, Semen Oroxyli 3g, Nodus Nelumbinis Rhizomatis 5g, Radix Ophiopogonis 5g, Flos Chrysanthemi 5g, Herba Menthae 3g, Radix Rehmanniae 5g, Rhizoma Imperatae 5g, Radix Glycyrrhizae 3g, by above-mentioned whole medical materials alcohol reflux 3 times, each concentration of alcohol is respectively 80%, 60%, 40%, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, each extraction time is respectively 3 hours, 2 hours, 1 hour, merge extractive liquid,, filter, filtrate is condensed into fluid extract, add supplementary product starch, ethanol, Pulvis Talci, make tablet.
Embodiment 6 capsules
Extracting honeysuckle 20g, Radix Isatidis 20g, Radix Platycodonis 14g, Radix Scrophulariae 14g, Lasiosphaera Seu Calvatia 8g, Semen Oroxyli 8g, Nodus Nelumbinis Rhizomatis 14g, Radix Ophiopogonis 14g, Flos Chrysanthemi 14g, Herba Menthae 8g, Radix Rehmanniae 14g, Rhizoma Imperatae 14g, Radix Glycyrrhizae 8g.By above-mentioned whole medical materials alcohol reflux 3 times, each concentration of alcohol is respectively 80%, 60%, 60%, each ethanol consumption is respectively 10 times, 8 times, 8 times of medical material total amount, each extraction time is respectively 2 hours, 2 hours, 1 hour, merge extractive liquid,, filters, and filtrate is condensed into fluid extract, add supplementary product starch, ethanol, dextrin, magnesium stearate, incapsulate shell, make capsule.
Embodiment 7 granules
Extracting honeysuckle 20g, Radix Isatidis 11g, Radix Platycodonis 8g, Radix Scrophulariae 12g, Lasiosphaera Seu Calvatia 6g, Semen Oroxyli 8g, Nodus Nelumbinis Rhizomatis 5g, Radix Ophiopogonis 10g, Flos Chrysanthemi 14g, Herba Menthae 3g, Radix Rehmanniae 10g, Rhizoma Imperatae 5g, Radix Glycyrrhizae 8g.Whole 12 taste medical materials except Herba Menthae, extracting in water 3 times, each amount of water is equivalent to respectively 10 times, 8 times, 8 times of medical material gross weight, each extraction time is respectively 2 hours, 2 hours, 1 hour, merge extractive liquid,, filters, and filtrate is condensed into 3 times of medical material gross weight; Get Herba Menthae, add 6 times of water extraction 0.5 hour of medical material weight, filter, filtrate and the merging of above-mentioned concentrated solution, mix, and the extractum that when filtrate is concentrated into 70 ℃, relative density is 1.25, adds adjuvant Icing Sugar, starch, dextrin, ethanol, makes granule.
Embodiment 8 powder
Take Flos Lonicerae 15g, Radix Isatidis 17g, Radix Platycodonis 5g, Radix Scrophulariae 10g, Lasiosphaera Seu Calvatia 5g, Semen Oroxyli 3g, Nodus Nelumbinis Rhizomatis 12g, Radix Ophiopogonis 14g, Flos Chrysanthemi 14g, Herba Menthae 3g, Radix Rehmanniae 5g, Rhizoma Imperatae 10g, Radix Glycyrrhizae 8g, medical material cleans, pulverizes, cross 80-100 mesh sieve, obtain powder of the present invention.
Clinical trial is summed up
The present invention is treated to the curative effect of acute/chronic pharyngitis and carry out clinical observation, check whether acute/chronic pharyngitis takes a turn for the better and analyze therapeutic effect of the present invention by the take medicine situation such as pharyngeal dry, scorching hot, cough, heating of Patients Before And After of contrast.
One. acute pharyngitis:
1 accepts 116 routine acute pharyngitis out-patients for medical treatment carries out clinical application observation, is divided at random treatment group and matched group.Treatment group 59 examples, male 32 examples, female's 27 examples, 3～55 years old age, average 30.3 years old.Average course of disease 1.61 days; Matched group 57 examples, male 29 examples, female's 28 examples, 5～59 years old age, average 28.2 years old.Average course of disease 1.58 days.Relatively there was no significant difference (P>0.05) of 2 groups of case physical data, has comparability.
2 diagnosis inclusive criterias:
2.1 onsets are more anxious, the course of disease 1～3 day;
2.2 diseases are seen initial pharyngeal dry, scorching hot, continue and pharyngalgia or odynophagia, and small number of patients can have heating, fear of cold, extremities aching pain, the symptoms such as inappetence;
2.3 check and see the hyperemia of pharyngeal mucosa Acute Diffuse, pharynx rear wall lymph follicle and lateral pharyngeal band redness, sometimes visible yellow-white point-like secretions, palatine arches, outstandingly stop up that hang down can edema.
3 observation index:
Symptom: dry pharynx sense, burning sensation, pharyngalgia, cough, heating etc.
Sign: pharyngeal mucosa hyperemia, retropharyneal folliculosis, lateral pharyngeal band swelling situation etc.
4 medications
Treatment group: the embodiment of the present invention 1 decoction, every day 2 times, each 250ml, after meal decoction being taken warmly.
Matched group: give precious yellow capsule (0.2g/ grain, Zhejiang Tian Yitang pharmaceutcal corporation, Ltd, the accurate word Z33020953 of authentication code traditional Chinese medicines) oral medication, 1 time 2,1 day 3 times.
It was 1 course for the treatment of that treatment group and matched group serve on 3.Ban use of during this time other treatment method and medicine, and ban on opium-smoking and the opium trade wine and pungent, irritative food.
5 efficacy assessment standards:
Clinical recovery: medication 3d alleviates with interior symptom, 5d disappears with interior symptom and sign, therapeutic index >=95%.
Effective: medication 5d obviously improves with interior symptom, sign, therapeutic index >=70%.
Effective: medication 5d makes moderate progress with interior symptom and sign, therapeutic index >=30%.
Invalid: medication 5d is not improved with interior symptom, sign, or therapeutic index <30%.
(therapeutic index N=(integration before (the rear integration of integration-treatment before treatment)/treatment] * 100%))
Acute pharyngitis acute pharyngitis observation of curative effect symptom and sign classification and observation of curative effect symptom and sign are marked in table 1, table 2.
Table 1 acute pharyngitis observation of curative effect symptom and sign hierarchical table
Table 2 acute pharyngitis observation of curative effect symptom and sign grade form
6 therapeutic outcomes: in table 3, table 4.
The comparison of two groups of patient's sings and symptoms total mark situations of table 3 acute pharyngitis (
point)
Note: relatively front with treatment,
△p<0.O1; With matched group comparison,
#p<0.01
Table 4 acute pharyngitis observation group and the comparison for the treatment of of control group result
Note: with matched group comparison,
*p<0.05
Conclusion: table 3 and the demonstration of table 4 clinical effectiveness, acute pharyngitis patient is after the present invention's treatment, and total effective rate reaches 93.2%, compared with prior art matched group, has significant difference, and clinical effectiveness shows that the present invention treats acute pharyngitis effect and is better than prior art.
Two, chronic pharyngitis
91 routine chronic pharyngitis out-patients are divided at random treatment group and matched group by 1.Treatment group 44 examples, male 23 examples, female's 21 examples, 20～65 years old age, average 36.3 years old, average course of disease 6.35 months.Matched group 47 examples, male 25 examples, female's 22 examples, 18～62 years old age, average 38.2 years old, average course of disease 5.97 months.Two groups of physical data contrast, and the situations such as its sex, age, severity extent, case distribution, cardinal symptom are learned and processed by statistics, P>0.05, and there was no significant difference, has comparability.
2 diagnosis inclusive criterias:
2.1 courses of disease are more than 2 months, and Chang Yin suffers from cold, catches a cold, tired etc., and reason causes symptom to increase the weight of;
2.2 disease is seen pharynx foreign body sensation, dry sensation, burning sensation or gargalesthesia, zest dry cough etc.;
2.3 check and see pharyngeal mucous membrane chronic congestion, or thicken, are dried, atrophy, attenuation, have secretions to adhere to, retropharyneal folliculosis or lateral pharyngeal band enlargement etc.
3 observation index:
3.1 symptoms: dry pharynx sense, burning sensation, foreign body sensation, itching throat, pharyngalgia, cough etc.
3.2 signs: pharyngeal mucosa hyperemia, retropharyneal folliculosis, lateral pharyngeal band swelling situation etc.
4 medications
Treatment group: give the embodiment of the present invention 1 decoction, every day 2 times, each 250ml, after meal decoction being taken warmly.
Matched group: give precious yellow capsule oral medication, 1 time 2,1 day 3 times.
It was 1 course for the treatment of that treatment group and matched group serve on 7.After patient takes medicine, after the 1st, 2,4 weeks, check, each patient all sets up observation registration form, records two groups of symptom and signs and changes situations and untoward reaction situation.
5 efficacy assessment standards:
Clinic control: in medication 10 days, cardinal symptom and sign alleviate, in 1 month, clinical symptoms and sign disappear, in 2 months without recurrence; Therapeutic index >=95%.
Effective: 2 weeks interior sings and symptomses of medication alleviate, and in 1 month, clinical symptoms and sign disappear, nothing recurrence in 2 months; Therapeutic index >=70%.
Effective: 2 weeks interior sings and symptomses of medication alleviate, and in 1 month, clinical symptoms and part sign disappear; Therapeutic index >=30%.
Invalid: in medication 1 month, symptom has and alleviates or without alleviating, sign is not improved; Therapeutic index <30%.
(therapeutic index N=(integration before (the rear integration of integration-treatment before treatment)/treatment] * 100%))
Chronic pharyngitis acute pharyngitis observation of curative effect symptom and sign classification and observation of curative effect symptom and sign are marked in table 5, table 6.
Table 5 chronic pharyngitis observation of curative effect symptom and sign hierarchical table
Table 6 chronic pharyngitis observation of curative effect symptom and sign grade form
6 therapeutic outcomes: in table 7.
Table 7 chronic pharyngitis observation group and the comparison for the treatment of of control group result
Note: with matched group comparison,
*p<0.05
As can be seen from Table 7, patients with chronic pharyngitis is treated after 1 month through the present invention, and total effective rate reaches 88.6%, compared with prior art matched group, has significant difference, and clinical effectiveness shows that the present invention treats chronic pharyngitis effect and is better than prior art.
Model case
Zeng, female, 12 years old, dry pharynx, rear odynophagia, coughs 1 day, extremities aching pain.Body is looked into: without heating, examines as anemopyretic acute pharyngitis, controls with heat-clearing and toxic substances removing, and lung qi dispersing sore-throat relieving, the present embodiment 2 syrups for prescription, the transference cure such as pharyngalgia, cough after 3 days, and after one week, have no recurrence, be judged as recovery from illness.
Liu, man, 65 years old, readme started cough, pharyngalgia after catching a cold before January.After diagnosing, pharyngeal mucous membrane chronic congestion, retropharyneal folliculosis, belongs to after diseases caused by exogenous pathogenic factor cause acute pharyngitis and transfers chronic pharyngitis to.Give the present embodiment 7 granules, pharyngalgia, cough transference cure after 3 days, and have no recurrence after one week, be judged as recovery from illness.
Thank certain, man, 33 years old, readme was caught a cold before three days, malaise, nasopharynx is dry, pharyngeal scorching hot pain.After diagnosing, genus wind heat is attacked outward and is caused acute pharyngitis.Give the present embodiment 4 mixture, pharyngalgia transference cure after 3 days, without expectorant, and has no recurrence after one week, is judged as recovery from illness.
Although, above use general explanation, the specific embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (8)
1. treat a Chinese medicine composition for acute/chronic pharyngitis, it is characterized in that it is to be prepared from by the raw material that comprises following weight portion: Flos Lonicerae 11-20 part, Radix Isatidis 11-20 part, Radix Platycodonis 5-14 part, Radix Scrophulariae 5-14 part, Lasiosphaera Seu Calvatia 3-8 part, Semen Oroxyli 3-8 part, Nodus Nelumbinis Rhizomatis 5-14 part, Radix Ophiopogonis 5-14 part, Flos Chrysanthemi 5-14 part, Herba Menthae 3-8 part, Radix Rehmanniae 5-14 part, Rhizoma Imperatae 5-14 part, Radix Glycyrrhizae 3-8 part.
2. the Chinese medicine composition for the treatment of acute/chronic pharyngitis as claimed in claim 1, is characterized in that it is to be prepared from by the raw material that comprises following weight portion: Flos Lonicerae 13-17 part, Radix Isatidis 13-17 part, Radix Platycodonis 8-12 part, Radix Scrophulariae 8-12 part, Lasiosphaera Seu Calvatia 5-7 part, Semen Oroxyli 5-7 part, Nodus Nelumbinis Rhizomatis 8-12 part, Radix Ophiopogonis 8-12 part, Flos Chrysanthemi 8-12 part, Herba Menthae 5-7 part, Radix Rehmanniae 8-12 part, Rhizoma Imperatae 8-12 part, Radix Glycyrrhizae 5-7 part.
3. the Chinese medicine composition for the treatment of acute/chronic pharyngitis as claimed in claim 1, is characterized in that it is to be prepared from by the raw material that comprises following weight portion: 15 parts of Flos Loniceraes, 15 parts of Radix Isatidis, 10 parts of Radix Platycodoniss, 10 parts of Radix Scrophulariaes, 6 parts of Lasiosphaera Seu Calvatia, 6 parts of Semen Oroxylis, 10 parts of Nodus Nelumbinis Rhizomatis, 10 parts of Radix Ophiopogonis, 10 parts of Flos Chrysanthemis, 6 parts of Herba Menthaes, 10 parts, the Radix Rehmanniae, 10 parts of Rhizoma Imperataes, 6 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition as described in claim 1-3 any one, the active component that it is characterized in that it is to adopt the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
5. Chinese medicine composition as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: whole 12 taste medical materials except Herba Menthae, extracting in water 2-3 time, each amount of water is equivalent to 8-10 times of medical material gross weight, each extraction time is 1-3 hour, merge extractive liquid,, filters, and filtrate is condensed into 3-4 times of medical material gross weight; Get Herba Menthae, add 6-8 times of water extraction 0.3-1 hour of medical material weight, filter, filtrate and above-mentioned concentrated solution merge, and obtain active component.
6. Chinese medicine composition as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: whole 12 taste medical materials except Herba Menthae, extracting in water 3 times, each amount of water is equivalent to 8-10 times of medical material gross weight, each extraction time is 1-2 hour, merge extractive liquid,, filters, and filtrate is condensed into 3 times of medical material gross weight; Get Herba Menthae, add 6-8 times of water extraction 0.3-0.5 hour of medical material weight, filter, filtrate and above-mentioned concentrated solution merge, and obtain active component.
7. Chinese medicine composition as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get whole 13 taste medical materials, with 40-80% alcohol reflux 2-3 time, the 4-10 that each ethanol consumption is medical material total amount doubly, extraction time is 1-3 hour, and merge extractive liquid, filters, filtrate is condensed into fluid extract, obtains active component.
8. treat a Chinese medicine composition for acute/chronic pharyngitis, comprise acceptable carrier in the Chinese medicine composition for the treatment of acute/chronic pharyngitis of any one in claim 1-3 and pharmaceuticals industry.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310739329.5A CN103768429A (en) | 2013-12-27 | 2013-12-27 | Traditional Chinese medicinal composition for treating acute and chronic pharyngitis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310739329.5A CN103768429A (en) | 2013-12-27 | 2013-12-27 | Traditional Chinese medicinal composition for treating acute and chronic pharyngitis and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103768429A true CN103768429A (en) | 2014-05-07 |
Family
ID=50561489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310739329.5A Pending CN103768429A (en) | 2013-12-27 | 2013-12-27 | Traditional Chinese medicinal composition for treating acute and chronic pharyngitis and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103768429A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352778A (en) * | 2014-12-10 | 2015-02-18 | 山东新希望六和集团有限公司 | Pharmaceutical composition for treating acute laryngitis of dogs and preparation method thereof |
| CN105434942A (en) * | 2015-12-22 | 2016-03-30 | 李龙 | Traditional Chinese medicine used for used for treating chronic pharyngolaryngitis |
| CN105617179A (en) * | 2016-01-20 | 2016-06-01 | 王浩 | Traditional Chinese medicine composition for treating chronic pharyngitis |
| CN106075370A (en) * | 2016-08-16 | 2016-11-09 | 安徽天乾健食品科技有限公司 | Chinese prescription of one group for the treatment of acute/chronic pharyngitis and preparation method thereof |
| CN106214860A (en) * | 2016-08-22 | 2016-12-14 | 陕西省中医药研究院汉唐制药有限公司 | For Chinese medicine composition treating acute/chronic pharyngitis and its preparation method and application |
-
2013
- 2013-12-27 CN CN201310739329.5A patent/CN103768429A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 张兴儒: "《新编临床常见病偏方验方全书》", 29 February 2008, 海科学技术文献出版社 * |
| 肖萍等: "咽喉汤治疗急性咽炎59例", 《中国中医药现代远程教育》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352778A (en) * | 2014-12-10 | 2015-02-18 | 山东新希望六和集团有限公司 | Pharmaceutical composition for treating acute laryngitis of dogs and preparation method thereof |
| CN105434942A (en) * | 2015-12-22 | 2016-03-30 | 李龙 | Traditional Chinese medicine used for used for treating chronic pharyngolaryngitis |
| CN105617179A (en) * | 2016-01-20 | 2016-06-01 | 王浩 | Traditional Chinese medicine composition for treating chronic pharyngitis |
| CN106075370A (en) * | 2016-08-16 | 2016-11-09 | 安徽天乾健食品科技有限公司 | Chinese prescription of one group for the treatment of acute/chronic pharyngitis and preparation method thereof |
| CN106214860A (en) * | 2016-08-22 | 2016-12-14 | 陕西省中医药研究院汉唐制药有限公司 | For Chinese medicine composition treating acute/chronic pharyngitis and its preparation method and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103505656B (en) | Chinese medicine preparation for treating stomatitis | |
| CN102091226B (en) | Chinese medicine composition for treating chronic pharyngitis | |
| CN103768429A (en) | Traditional Chinese medicinal composition for treating acute and chronic pharyngitis and preparation method thereof | |
| CN104189588A (en) | Vitamin C Yinqiao tablets and preparation method thereof | |
| CN104324125B (en) | Traditional Chinese medicine composition for treating chronic pharyngitis and preparation method thereof | |
| CN101979022A (en) | Chinese medicinal mixture for treating chronic rhinitis | |
| CN101953996B (en) | Chinese medicinal composition for treating acute tonsillitis | |
| CN101549016B (en) | Traditional Chinese medicine composition for treating acute and chronic pharyngitis and preparation method thereof | |
| CN102335373B (en) | Chinese medicinal composition for treating upper respiratory tract infection, and preparation method thereof | |
| CN104983968B (en) | Antipyretic traditional Chinese medicine composition and preparation method thereof | |
| WO2023125798A1 (en) | Traditional chinese medicine composition and preparation method and application thereof | |
| CN105055841A (en) | Medicine for treating chronic pharyngitis and preparing method thereof | |
| CN102258650B (en) | External rhinitis paste | |
| CN101670050B (en) | Traditional Chinese medicine composition for treating chronic pharyngitis | |
| CN102600391A (en) | Traditional Chinese medicine composition for treating pediatric acute tonsillitis | |
| CN105879000A (en) | Pharmaceutic preparation for treating tonsillitis and application thereof | |
| CN105748899A (en) | Pharmaceutical preparation for treating pharyngitis and use thereof | |
| CN104524256A (en) | Traditional Chinese medicine for treating viral pneumonia | |
| CN104042878A (en) | Cough syrup and preparation method thereof | |
| CN115040613B (en) | Traditional Chinese medicine composition for improving fever symptoms of viral influenza, application and preparation | |
| CN104524187B (en) | A kind of Chinese medicine preparation for the treatment of laryngopharynx swelling and pain and preparation method thereof | |
| CN102885929A (en) | Traditional Chinese medicine preparation for treating throat inflammations and preparation method thereof | |
| CN102631554B (en) | Traditional Chinese medicinal composition for treating periodontitis | |
| CN108815376B (en) | Throat-clearing and sore-throat-relieving tea | |
| CN115192680A (en) | Preparation method and efficacy of medicine for treating influenza |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: LIUZHOU CITY HELATH CENTRE FOR WOMAN AND CHILDREN Free format text: FORMER OWNER: LIUZHOU WORKERS HOSPITAL Effective date: 20150804 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20150804 Address after: 545001 the Guangxi Zhuang Autonomous Region Yingshan City District of Liuzhou City Street No. fifty Applicant after: Liuzhou City Women and Children Hospital Address before: 545005 the Guangxi Zhuang Autonomous Region, Liuzhou Liu Shi Road, No. 1 Applicant before: LIUZHOU WORKER'S HOSPITAL |
|
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140507 |
|
| RJ01 | Rejection of invention patent application after publication |