CN104352778A - Pharmaceutical composition for treating acute laryngitis of dogs and preparation method thereof - Google Patents

Pharmaceutical composition for treating acute laryngitis of dogs and preparation method thereof Download PDF

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Publication number
CN104352778A
CN104352778A CN201410750360.3A CN201410750360A CN104352778A CN 104352778 A CN104352778 A CN 104352778A CN 201410750360 A CN201410750360 A CN 201410750360A CN 104352778 A CN104352778 A CN 104352778A
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weight portion
radix
pharmaceutical composition
fructus
ethanol
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胡莉萍
吕明斌
燕磊
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Shandong New Hope Liuhe Group Co Ltd
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Shandong New Hope Liuhe Group Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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Abstract

The invention discloses a pharmaceutical composition for treating acute laryngitis of dogs and a preparation method thereof. The pharmaceutical composition comprises the following raw medicinal materials: folium mori, gypsum, Radix Ophiopogonis, radix polygonati officinalis, laminated sanicle herb, periostracum cicada, flos farfarae, root of rehmannia, rhizoma polygonati, wolfberry, burdock, emblic leafflower fruit, radix tinosporae, nori, Licorice Roots Northwest Origin, blackberry lily, puffball, purslane, cleavers, indigo naturalis, mother chrysanthemum and isatis root. The pharmaceutical composition disclosed by the invention has the beneficial effects that the pharmaceutical composition disclosed by the invention has the main effects of nourishing lung and kidney, decreasing internal heat, relieving sore throat and easing-up the voice, tonifying Qi and benefiting lung and promoting the circulation of qi, activating blood circulation and reducing phlegm and the auxiliary effects of reinforcing qi and nourishing blood and regulating qi-flowing for strengthening spleen, can enhance the body resistance and has the advantages and characteristics such as significant benefits, precise and appropriate material selection, high quality, low price, safety, applicability and zero drug residue in the aspect of treating the acute laryngitis of dogs.

Description

Be used for the treatment of pharmaceutical composition of Canis familiaris L. acute laryngitis and preparation method thereof
Technical field
The present invention relates to field of veterinary, particularly relate to and be a kind ofly used for the treatment of pharmaceutical composition of Canis familiaris L. acute laryngitis and preparation method thereof.
Background technology
The acute laryngitis cause of disease of Canis familiaris L.: (one) Abwehrkraft des Koepers is low: after Common Cold, systemic resistance power reduces, and can bring out.Start mostly to be viral infection, later antibacterial is taken advantage of a weak point.Wherein with Diplococcus pneumoniae, hemophilus influenza, Hemolytic streptococcus etc. are common.(2) environmental factors: excessive with throat; Adjoin factory and suck too much harmful gas or industrial dust (as chlorine, bromine, iodine, nitric acid, sulphuric acid etc.) (three) acute infectious disease: the primary disease also acute infectious disease such as normal and measles, pertussis, influenza, scarlet fever merges generation.(4) wound: foreign bodies in the larynx stimulation etc.
Symptom is: 1. hoarseness is topmost symptom, and sound step-down is heavy, coarse, and it is heavier that morning plays symptom, increases with activity, expectoration throat portion secretion and taking a turn for the better gradually.After unvoicing, hoarseness alleviates, and roars more and makes exacerbation of symptoms again, in intermittent, with the passing of time develops into persistence.2. throat portion secretion increases, and often feels have expectorant to adhere to.
Laryngitis itself is also not serious, if but ignore treatment, very easily cause the complication of general, and be fatal, pharyngolaryngitis harm is large.Acute and chronic pharyngitis harm shows as that laryngopharynx swelling and pain, xerostomia, larynx are dry, itching throat, pharyngeal burning sensation, dry cough without phlegm, bottleneck throat has in obvious follicle hypertrophy, pharynx and has foreign body sensation, difficulty of handling up, serious time hoarseness, dizzy, uncomfortable in chest, even spitting of blood etc.Obstinate easily brings out the generation of the complication such as bronchitis, pneumonia, myocarditis, laryngocarcinoma, esophageal carcinoma.
Chinese veterinarian thinks, and diaphragm has wind heat, then laryngopharynx swelling and pain, if the heresy of wind heat is contained, then raw single two newborn pretty young woman, also therefore named.Thermoae, swollen to close, soup not under, speech difficulty goes out, and breathe obstructed, name says sore throat.If the more double abundant expectoration of extreme heat causing wind syndrome, then sputum is around between larynx, sound throat, inside and outsidely swollen to close, soup not under, name says bond-throat syndrome, all endangers disease also.Laryngitis, the thoroughfare of throat traffic, the ground of meridians plan and control, with lung, the heart, liver, kidney is correlated with.Fire has hot characteristic, prosperous in summer, from the Spring Equinox, Clear and Bright, grain rains, to four solar term in the Beginning of summer, is the main order of fire of moxibustion.Because of main fire in summer, therefore fire is corresponding to the motive.But fight not resemble summer-heat and there is obvious seasonality, also not by the restriction of seasonal climate.
Summary of the invention
Technical problem to be solved by this invention is that providing a kind of is used for the treatment of pharmaceutical composition of Canis familiaris L. acute laryngitis and preparation method thereof, wherein pharmaceutical composition nourishing the lung and kidney, pathogenic fire reducing relieving sore throat to recover voice, using tonifying Qi reinforcing lungs, promoting flow of QI and blood reduces phlegm simultaneously, can benefiting QI and nourishing blood, regulating qi-flowing for strengthening spleen, strengthen its resistivity and immunity, in the acute laryngitis for the treatment of Canis familiaris L., there is the advantages such as evident in efficacy, cheap, nonhazardous, no drug residue, pure natural property, safe ready, complete function.
In order to realize foregoing invention object, the invention provides a kind of pharmaceutical composition being used for the treatment of Canis familiaris L. acute laryngitis, comprise following raw medicinal material: Folium Mori, Gypsum Fibrosum, Radix Ophiopogonis, Rhizoma Polygonati Odorati, Herba Saniculae lamelligerae, Periostracum Cicadae, Flos Farfarae, the Radix Rehmanniae, Rhizoma Polygonati, Fructus Lycii, Fructus Arctii, Fructus Phyllanthi, Radix Tinosporae, Thallus Porphyrae, Radix Glycyrrhizae, Rhizoma Belamcandae, Lasiosphaera Seu Calvatia, Herba Portulacae, Herba Galii Teneri, Indigo Naturalis, Flos Chrysanthemi Indici and Radix Isatidis Folium Mori, Gypsum Fibrosum, Radix Ophiopogonis, Rhizoma Polygonati Odorati, Herba Saniculae lamelligerae, Periostracum Cicadae, Flos Farfarae, the Radix Rehmanniae, Rhizoma Polygonati, Fructus Lycii, Fructus Arctii, Fructus Phyllanthi, Radix Tinosporae, Thallus Porphyrae, Radix Glycyrrhizae, Rhizoma Belamcandae, Lasiosphaera Seu Calvatia, Herba Portulacae, Herba Galii Teneri, Indigo Naturalis, Flos Chrysanthemi Indici and Radix Isatidis.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Folium Mori 16-27 weight portion, Gypsum Fibrosum 5-10 weight portion, Radix Ophiopogonis 12-19 weight portion, Rhizoma Polygonati Odorati 10-15 weight portion, Herba Saniculae lamelligerae 12-22 weight portion, Periostracum Cicadae 12-20 weight portion, Flos Farfarae 10-18 weight portion, Radix Rehmanniae 25-37 weight portion, Rhizoma Polygonati 14-25 weight portion, Fructus Lycii 15-28 weight portion, Fructus Arctii 12-21 weight portion, Fructus Phyllanthi 10-17 weight portion, Radix Tinosporae 10-15 weight portion, Thallus Porphyrae 10-18 weight portion, Radix Glycyrrhizae 10-18 weight portion, Rhizoma Belamcandae 12-19 weight portion, Lasiosphaera Seu Calvatia 8-13 weight portion, Herba Portulacae 12-18 weight portion, Herba Galii Teneri 10-14 weight portion, Indigo Naturalis 9-18 weight portion, Flos Chrysanthemi Indici 10-19 weight portion and Radix Isatidis 15-25 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Folium Mori 25 weight portion, Gypsum Fibrosum 6 weight portion, Radix Ophiopogonis 15 weight portion, Rhizoma Polygonati Odorati 12 weight portion, Herba Saniculae lamelligerae 17 weight portion, Periostracum Cicadae 16 weight portion, Flos Farfarae 13 weight portion, the Radix Rehmanniae 32 weight portion, Rhizoma Polygonati 21 weight portion, Fructus Lycii 27 weight portion, Fructus Arctii 19 weight portion, Fructus Phyllanthi 13 weight portion, Radix Tinosporae 11 weight portion, Thallus Porphyrae 14 weight portion, Radix Glycyrrhizae 18 weight portion, Rhizoma Belamcandae 12 weight portion, Lasiosphaera Seu Calvatia 8 weight portion, Herba Portulacae 16 weight portion, Herba Galii Teneri 12 weight portion, Indigo Naturalis 13 weight portion, Flos Chrysanthemi Indici 16 weight portion and Radix Isatidis 22 weight portion.
Described pharmaceutical composition also comprises the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chiritae Fimbrisepalae and Fructus Setariae Germinatus.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Folium Mori 16-27 weight portion, Gypsum Fibrosum 5-10 weight portion, Radix Ophiopogonis 12-19 weight portion, Rhizoma Polygonati Odorati 10-15 weight portion, Herba Saniculae lamelligerae 12-22 weight portion, Periostracum Cicadae 12-20 weight portion, Flos Farfarae 10-18 weight portion, Radix Rehmanniae 25-37 weight portion, Rhizoma Polygonati 14-25 weight portion, Fructus Lycii 15-28 weight portion, Fructus Arctii 12-21 weight portion, Fructus Phyllanthi 10-17 weight portion, Radix Tinosporae 10-15 weight portion, Thallus Porphyrae 10-18 weight portion, Radix Glycyrrhizae 10-18 weight portion, Rhizoma Belamcandae 12-19 weight portion, Lasiosphaera Seu Calvatia 8-13 weight portion, Herba Portulacae 12-18 weight portion, Herba Galii Teneri 10-14 weight portion, Indigo Naturalis 9-18 weight portion, Flos Chrysanthemi Indici 10-19 weight portion, Radix Isatidis 15-25 weight portion, Radix Astragali 12-20 weight portion, Radix Codonopsis 12-18 weight portion, Radix Angelicae Sinensis 8-16 weight portion, Rhizoma Chiritae Fimbrisepalae 3-9 weight portion and Fructus Setariae Germinatus 8-17 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Folium Mori 25 weight portion, Gypsum Fibrosum 6 weight portion, Radix Ophiopogonis 15 weight portion, Rhizoma Polygonati Odorati 12 weight portion, Herba Saniculae lamelligerae 17 weight portion, Periostracum Cicadae 16 weight portion, Flos Farfarae 13 weight portion, the Radix Rehmanniae 32 weight portion, Rhizoma Polygonati 21 weight portion, Fructus Lycii 27 weight portion, Fructus Arctii 19 weight portion, Fructus Phyllanthi 13 weight portion, Radix Tinosporae 11 weight portion, Thallus Porphyrae 14 weight portion, Radix Glycyrrhizae 18 weight portion, Rhizoma Belamcandae 12 weight portion, Lasiosphaera Seu Calvatia 8 weight portion, Herba Portulacae 16 weight portion, Herba Galii Teneri 12 weight portion, Indigo Naturalis 13 weight portion, Flos Chrysanthemi Indici 16 weight portion, Radix Isatidis 22 weight portion, the Radix Astragali 18 weight portion, Radix Codonopsis 15 weight portion, Radix Angelicae Sinensis 13 weight portion, Rhizoma Chiritae Fimbrisepalae 5 weight portion and Fructus Setariae Germinatus 9 weight portion
The dosage form of described pharmaceutical composition is spray, and its preparation method comprises the following steps:
A, take all raw medicinal materials in described ratio, add relative to the mixture quality 3-5 obtained water water soaking 3-10 hour doubly, after intense fire boils, use slow fire instead and decoct 30-50 minute slowly, decoct 3 times, merge decoction liquor and filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;
B, the medicinal residues of step a are added 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, filters, concentrated, 80-160 order filters, 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;
C, extractum 1 and extractum 2 are mixed, thin up obtains aqueous premix;
D, under explosion-proof environment condition, in tank with cover, add aqueous premix 8-10 dehydrated alcohol doubly, then slowly stir, slowly add the aqueous premix obtained in step c;
E, continue slowly to add aqueous premix 1-2 doubly 99.6% glycerol, stir until obtain limpid solution;
F, with 6 μm, and the filter cartridge type filter of ethanol tolerant it to be filtered, and be sent to filling machine, canned in 100ml slush moulding vial with can packing machine; After sterilizing gland, temperature controls, at 25 DEG C, to pour propellant iso-butane by upper valve; Net volume after valve is packaged is 80ml.
The dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:
The first step, Folium Mori, Radix Ophiopogonis, Rhizoma Polygonati Odorati, Herba Saniculae lamelligerae, Periostracum Cicadae, Flos Farfarae, the Radix Rehmanniae, Rhizoma Polygonati and Fructus Lycii are mixed in described ratio, with being the dissolve with ethanol of 85% ~ 95% relative to the determining alcohol of 3 ~ 5 times of mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Fructus Arctii, Fructus Phyllanthi and Radix Tinosporae are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 80 ~ 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.
The present invention also provides a kind of preparation method being used for the treatment of the pharmaceutical composition of Canis familiaris L. acute laryngitis, and the dosage form of described pharmaceutical composition is spray, and its preparation method comprises the following steps:
A, take all raw medicinal materials in described ratio, add relative to the mixture quality 3-5 obtained water water soaking 3-10 hour doubly, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, decoct 3 times, merge decoction liquor to filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;
B, the medicinal residues of step a are added 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, filters, concentrated, 80-160 order filters, 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;
C, extractum 1 and extractum 2 are mixed, thin up obtains aqueous premix;
D, under explosion-proof environment condition, in tank with cover, add aqueous premix 8-10 dehydrated alcohol doubly, then slowly stir, slowly add the aqueous premix obtained in step c;
E, continue slowly to add aqueous premix 1-2 doubly 99.6% glycerol, stir until obtain limpid solution;
F, with 6 μm, and the filter cartridge type filter of ethanol tolerant it to be filtered, and be sent to filling machine, canned in 100ml slush moulding vial with can packing machine; After sterilizing gland, temperature controls, at 25 DEG C, to pour propellant iso-butane by upper valve; Net volume after valve is packaged is 80ml.
The present invention also provides a kind of preparation method being used for the treatment of the pharmaceutical composition of Canis familiaris L. acute laryngitis, and the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:
The first step, Folium Mori, Radix Ophiopogonis, Rhizoma Polygonati Odorati, Herba Saniculae lamelligerae, Periostracum Cicadae, Flos Farfarae, the Radix Rehmanniae, Rhizoma Polygonati and Fructus Lycii are mixed in described ratio, with being the dissolve with ethanol of 85% ~ 95% relative to the determining alcohol of 3 ~ 5 times of mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Fructus Arctii, Fructus Phyllanthi and Radix Tinosporae are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 80 ~ 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: pharmaceutical composition of the present invention is with nourishing the lung and kidney, pathogenic fire reducing relieving sore throat to recover voice, using tonifying Qi reinforcing lungs, it is main that promoting flow of QI and blood reduces phlegm, with benefiting QI and nourishing blood, regulating qi-flowing for strengthening spleen is auxiliary, can strengthen its resistivity, have in the acute laryngitis for the treatment of Canis familiaris L. merit specially imitate grand, select YAOJING to work as, the advantage such as super quality and competitive price, safe and applicable, drug residue free.
detailed description of the invention
Chinese veterinarian thinks, and diaphragm has wind heat, then laryngopharynx swelling and pain, if the heresy of wind heat is contained, then raw single two newborn pretty young woman, also therefore named.Thermoae, swollen to close, soup not under, speech difficulty goes out, and breathe obstructed, name says sore throat.If the more double abundant expectoration of extreme heat causing wind syndrome, then sputum is around between larynx, sound throat, inside and outsidely swollen to close, soup not under, name says bond-throat syndrome, all endangers disease also.Laryngitis, the thoroughfare of throat traffic, the ground of meridians plan and control, with lung, the heart, liver, kidney is correlated with.Fire has hot characteristic, prosperous in summer, from the Spring Equinox, Clear and Bright, grain rains, to four solar term in the Beginning of summer, is the main order of fire of moxibustion.Because of main fire in summer, therefore fire is corresponding to the motive.But fight not resemble summer-heat and there is obvious seasonality, also not by the restriction of seasonal climate.
For the corresponding symptom that the acute laryngitis suffering from Canis familiaris L. occurs, the invention provides one to have and can nurse one's health Canis familiaris L. spleen and stomach function, treatment short treating period, effect is better, residual quantity low while can enhancing immunity and resistivity, nourishing the lung and kidney, pathogenic fire reducing relieving sore throat to recover voice, using tonifying Qi reinforcing lungs, promoting flow of QI and blood reduces phlegm, Chinese medicine composition of green non-pollution and preparation method thereof.
Wherein, Chinese medicine composition comprises: Folium Mori, Gypsum Fibrosum, Radix Ophiopogonis, Rhizoma Polygonati Odorati, Herba Saniculae lamelligerae, Periostracum Cicadae, Flos Farfarae, the Radix Rehmanniae, Rhizoma Polygonati, Fructus Lycii, Fructus Arctii, Fructus Phyllanthi, Radix Tinosporae, Thallus Porphyrae, Radix Glycyrrhizae, Rhizoma Belamcandae, Lasiosphaera Seu Calvatia, Herba Portulacae, Herba Galii Teneri, Indigo Naturalis, Flos Chrysanthemi Indici and Radix Isatidis.Preferably, the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chiritae Fimbrisepalae and Fructus Setariae Germinatus can also also be comprised.Wherein, Folium Mori, Gypsum Fibrosum, Radix Ophiopogonis, Rhizoma Polygonati Odorati, Herba Saniculae lamelligerae, Periostracum Cicadae, Flos Farfarae lung moistening clearing away dryness, sore-throat relieving removing heat from blood sound producing; Larynx controlled by Radix Glycyrrhizae, Rhizoma Belamcandae Hydrargyri Oxydum Rubrum, and priming playbacks, and medicine is gone directly focus; Rhizoma Polygonati, Fructus Lycii, Radix Rehmanniae boosting qi and nourishing yin, lung moistening; Fructus Arctii, Fructus Phyllanthi, Radix Tinosporae, Thallus Porphyrae, Lasiosphaera Seu Calvatia, Herba Portulacae, Herba Galii Teneri, Indigo Naturalis, Flos Chrysanthemi Indici, Radix Isatidis heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; The Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chiritae Fimbrisepalae and Fructus Setariae Germinatus benefiting QI and nourishing blood, regulating qi-flowing for strengthening spleen.
The pharmacological property of above-mentioned each raw medicinal material is as follows:
Folium Mori: sweet, bitter, cold.Return lung, Liver Channel.Dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.For anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.
Gypsum Fibrosum: sweet, pungent, Great Cold.Attach to the lung and stomach meridians.Clearing away heat-fire, relieving restlessness is quenched the thirst.For fever caused by exogenous pathogenic factors, high hot excessive thirst, dyspnea and cough due to lung-heat, the high Sheng of stomach-fire, headache, toothache.
Radix Ophiopogonis: sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease is coughed, and Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.
Rhizoma Polygonati Odorati: sweet, is slightly cold.Attach to the lung and stomach meridians.Nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.For lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.
Herba Saniculae lamelligerae: acrid in the mouth; Sweet; Slightly warm in nature.Return lung; Liver Channel.Dispel the wind and deliver; Preventing phlegm from forming and stopping coughing; Promoting blood flow to regulate menstruation.Main flu; Cough; Asthma; Menoxenia; Amenorrhea; Dysmenorrhea; Skin ulcer swells; Treating swelling and pain by traumatic injury; Traumatic hemorrhage, clearing heat and moistening lung, promoting the circulation of blood is stimulated the menstrual flow.
Periostracum Cicadae: sweet, cold.Return lung, Liver Channel.Loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.
Flos Farfarae: pungent, micro-hardship, temperature.Return lung meridian.Nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm.Cough for new chronic cough, dyspnea and cough with excessive sputum, chronic cough hemoptysis.
The Radix Rehmanniae: sweet, cold; GUIXIN, liver, kidney channel.Shennong's Herbal: " sweet in the mouth, cold.Cure mainly folding to fall, exhausted muscle, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fill out bone marrow, longue meat.Make soup except cold and heat and gather, eliminating impediment.Survivor is especially good." heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, removing heat from blood, hemostasis invigorate blood circulation.The Radix Rehmanniae is cold in nature, and function is heat clearing and blood cooling, enriching yin and nourishing kidney, promoting the production of body fluid to quench thirst, is usually used in the diseases such as treatment hectic fever due to YIN-deficiency consumptive disease heat, throat pain, sputum mixed with blood.
Rhizoma Polygonati: sweet is flat.Return spleen, lung, kidney channel.Boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.
Fructus Lycii: sweet is flat.Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Fructus Arctii: pungent, bitter, cold.Attach to the lung and stomach meridians.Dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.For anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, mumps erysipelas, carbuncle sore tumefacting virus.
Fructus Phyllanthi: bitter in the mouth; Sweet; Acid; Cool in nature.Return spleen; Stomach warp, relieving sore-throat by clearing away heat; Moistening the lung and resolving phlegm; Promoting the production of body fluid to quench thirst.Main cold, fever; Cough; Pharyngalgia; Diphtheria; Dysphoria with smothery sensation is thirsty; Hypertension
Radix Tinosporae: bitter, cold.Return lung, large intestine channel.Heat-clearing and toxic substances removing, sore-throat relieving, pain relieving.For laryngopharynx swelling and pain, carbuncle furunculosis, has loose bowels, dysentery, gastral cavity abdomen burning pain.
Thallus Porphyrae: sweet; Salty; Cold.Lung, spleen, urinary bladder channel.Resolving phlegm and softening hard masses; Sore-throat relieving; Cough-relieving; To nourish heart relieving restlessness; Diuretic dehumidifies.Main goiter; Foot gas; Edema; Laryngopharynx swelling and pain; Cough; Irritated insomnia; Urine leaching pain; Dysentery.
Radix Glycyrrhizae: nature and flavor are sweet, cold.Enter spleen, stomach, lung meridian.Spleen reinforcing lung meridian, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription." herbal classic " is said: " main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound swells, removing toxic substances "." property of medicine opinion " is said: " in main abdomen, cold type of pain, controls infantile convulsion, except distention and fullness in the abdomen; Tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make flaccidity; Housewife's human blood drop lumbago; Empty and frequent fever; Add and with it ".Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Rhizoma Belamcandae: nature and flavor are bitter, cold.Enter lung, Liver Channel.There is heat-clearing and toxic substances removing, throat, expectorant saliva, treat pharynx and close, effect of eliminating carbuncle poison.Modern study shows, it has the effect of resisting pathogenic microbes, antiinflammatory.
Lasiosphaera Seu Calvatia: pungent, flat, nontoxic.Main be used as local hemostatic, doublely control throat pain, aphonia etc.Traumatic hemorrhage, epistaxis, postextraction hemorrhage: Lasiosphaera Seu Calvatia tears epithelium off, gets inner sponge floss sample thing compressing bleeding part or fills in nostril, filling gingiva place, have good hemostatic function.
Herba Portulacae: nature and flavor are sour, cold.Return liver, large intestine channel.Heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.Tang Materia Medica: main all swollen fistula verruca, smashes and wipes it; The main regurgitation of drink juice, Zhu Lin, incised wound blood flow, removing blood stasis addiction disease addiction, children's You Liang; Wash tight lip, pimples, horse antiperspirant with juice, penetrate being recovered of work poison painting.Effect has heat-clearing and toxic substances removing, loose blood detumescence.Control hematodiarrhoea pus and blood, pyretic stranguria, stranguria with blood, leukorrhagia, carbuncle malignant boil, erysipelas, trace scrofula.
Herba Galii Teneri: another name: draw rattan, Galium spurium L., spire Radix Rubiae, saw grass, little saw grass, HUOXUECAO, little standing grain sickle grass, saw Auricled Hedyotis Herb.Source: Rubiaceae clivers Herba Galii Teneri Galium aparine L. var. tenerum (Gren. et Godr.) Reichb. is with all herbal medicine.Summer gathers, using fresh herb or dry.Toil, cold.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " acrid in the mouth is bitter, cold nature." 2. " Guangxi Chinese medicinal herbal: " puckery, property is put down." 3. " Hunan medicine will ": " is sweet puckery, is slightly cold." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enters few cloudy, Taiyin channels." clearing away damp-heat, dissipating blood stasis, detumescence, removing toxic substances.Control stranguria with turbid discharge, hematuria, traumatic injury, acute appendicitis, furuncle and phyma, otitis media.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control damp and hot, all through exopathogenic heat, chronic consumptive disease, virgin consumptive disease, bones and muscles pain, pyretic stranguria, red white turbid urine, beautiful pain in the penis.Move back blood system dysphoria with smothery sensation, only hematuria." 2. " Guizhou side's medicine among the people collection ": " controls scabies." 3. " Guangxi Chinese medicinal herbal ": " controls married woman's dysmenorrhea.Mash again extracting juice and rush sticky rice syrup, control and fly upward skin ulcer." 4. Jiangxi " medical herbs handbook ": " heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Control carbuncle, appendicitis, closely for for cancer.5. " Kunming conventional medical herbs among the people ": " dissipating blood stasis blood, controls phlegm-fire heat symptom-complex, and acute conjunctivitis mist gum is many, rheumatic bone-setting pain for heat clearing and inflammation relieving, wind-damp dispelling, the subcutaneous congestive edema of wound." 6. " Yunnan Chinese herbal medicine ": " clearing away heat and cooling blood, diuresis.Control stranguria with blood, urinary tract infection."
Indigo Naturalis: salty in the mouth, cold in nature, enter Liver Channel, there is effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, purging liver-fire, send out the cards such as all cards of pyretic toxicity such as speckle, haematemesis, laryngopharynx swelling and pain, herpes eczema, liver-fire invading the lung, cough chest pain, sputum mixed with blood, high hot infantile convulsion, convulsion with spasms for epidemic febrile disease.
Flos Chrysanthemi Indici: cold nature, bitter in the mouth, pungent.Heat-clearing and toxic substances removing, furuncle of drawing out pus by applying a plaster to the affected part." book on Chinese herbal medicine converges and says ": " removing blood stasis is soothing the liver, separates the loose poison of furuncle.Stagnated blood in housewife people's abdomen, the red furuncle of the capable fire-toxin of Xie Tian.Wash skin ulcer scabies, wind parasite killing can be removed again." function heat-clearing and toxic substances removing, detumescence.To staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, puncture Shigella, influenza virus, all there is inhibitory action.
Radix Isatidis: nature and flavor, bitter cold.Heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving.Cure mainly maculae caused by violent heat pathogen, high heat headache, major part pestilence, crimson tongue is purple dark, scarlet fever, erysipelas, mumps, sore throat, and skin ulcer is swollen, carbuncle, chickenpox, measles, hepatitis, influenza, epidemic encephalitis, encephalitis b, pneumonia, and coma tells nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis can be prevented and treated.
The Radix Astragali: sweet, temperature.Return lung, spleen channel.Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Radix Codonopsis: property is put down, sweet in the mouth, micro-acid.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Rhizoma Chiritae Fimbrisepalae: micro-hardship is cool, nontoxic.Strengthening the spleen to promote digestion, removing damp-heat.Control infant malnutrition, hepatitis.
Fructus Setariae Germinatus: bitter in the mouth; Slightly warm in nature.Return spleen; Stomach warp.Spleen invigorating; Help digestion.Staple food amasss distension; Anorexia.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 pharmaceutical composition 1
Embodiments provide a kind of pharmaceutical composition being used for the treatment of Canis familiaris L. acute laryngitis, be made up of the raw medicinal material of following parts by weight: Folium Mori 25 weight portion, Gypsum Fibrosum 6 weight portion, Radix Ophiopogonis 15 weight portion, Rhizoma Polygonati Odorati 12 weight portion, Herba Saniculae lamelligerae 17 weight portion, Periostracum Cicadae 16 weight portion, Flos Farfarae 13 weight portion, the Radix Rehmanniae 32 weight portion, Rhizoma Polygonati 21 weight portion, Fructus Lycii 27 weight portion, Fructus Arctii 19 weight portion, Fructus Phyllanthi 13 weight portion, Radix Tinosporae 11 weight portion, Thallus Porphyrae 14 weight portion, Radix Glycyrrhizae 18 weight portion, Rhizoma Belamcandae 12 weight portion, Lasiosphaera Seu Calvatia 8 weight portion, Herba Portulacae 16 weight portion, Herba Galii Teneri 12 weight portion, Indigo Naturalis 13 weight portion, Flos Chrysanthemi Indici 16 weight portion and Radix Isatidis 22 weight portion.
Its spray preparation method comprises the following steps:
A, take all raw medicinal materials in described ratio, add the water water soaking 5 hours relative to the mixture quality 4 times obtained, after intense fire boils, use slow fire instead and decoct 40 minutes slowly, decocts 3 times, merge decoction liquor filtration, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;
B, the medicinal residues of step a are added 80% soak with ethanol 1 hour, extract twice, each 2 hours, merge extractive liquid, filters, concentrated, 120 orders filter, 10000 revs/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;
C, extractum 1 and extractum 2 are mixed, thin up obtains aqueous premix;
D, under explosion-proof environment condition, in tank with cover, add the dehydrated alcohol of aqueous premix 9 times, then slowly stir, slowly add the aqueous premix obtained in step c;
E, continue slowly to add the glycerol of aqueous premix 1 times 99.6%, stir until obtain limpid solution;
F, with 6 μm, and the filter cartridge type filter of ethanol tolerant it to be filtered, and be sent to filling machine, canned in 100ml slush moulding vial with can packing machine; After sterilizing gland, temperature controls, at 25 DEG C, to pour propellant iso-butane by upper valve; Net volume after valve is packaged is 80ml.
Embodiment 2 pharmaceutical composition 2
Embodiments provide a kind of pharmaceutical composition being used for the treatment of Canis familiaris L. acute laryngitis, be made up of the raw medicinal material of following parts by weight:
Folium Mori 25 weight portion, Gypsum Fibrosum 6 weight portion, Radix Ophiopogonis 15 weight portion, Rhizoma Polygonati Odorati 12 weight portion, Herba Saniculae lamelligerae 17 weight portion, Periostracum Cicadae 16 weight portion, Flos Farfarae 13 weight portion, the Radix Rehmanniae 32 weight portion, Rhizoma Polygonati 21 weight portion, Fructus Lycii 27 weight portion, Fructus Arctii 19 weight portion, Fructus Phyllanthi 13 weight portion, Radix Tinosporae 11 weight portion, Thallus Porphyrae 14 weight portion, Radix Glycyrrhizae 18 weight portion, Rhizoma Belamcandae 12 weight portion, Lasiosphaera Seu Calvatia 8 weight portion, Herba Portulacae 16 weight portion, Herba Galii Teneri 12 weight portion, Indigo Naturalis 13 weight portion, Flos Chrysanthemi Indici 16 weight portion, Radix Isatidis 22 weight portion, the Radix Astragali 18 weight portion, Radix Codonopsis 15 weight portion, Radix Angelicae Sinensis 13 weight portion, Rhizoma Chiritae Fimbrisepalae 5 weight portion and Fructus Setariae Germinatus 9 weight portion.
Its preparation method comprises the following steps:
The first step, Folium Mori, Radix Ophiopogonis, Rhizoma Polygonati Odorati, Herba Saniculae lamelligerae, Periostracum Cicadae, Flos Farfarae, the Radix Rehmanniae, Rhizoma Polygonati and Fructus Lycii are mixed in described ratio, be the soak with ethanol of 95% with the determining alcohol of 4 times relative to the mixture quality obtained, reflux was extracted after 3 hours, filter, obtain the first filtrate; By filtering residue again by the soak with ethanol of the determining alcohol 95% of 1 times relative to the mixture quality obtained, reflux was extracted after 2 hours, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Fructus Arctii, Fructus Phyllanthi and Radix Tinosporae are mixed in described ratio, add the ethanol of the determining alcohol 95% of 3 times relative to the mixture quality obtained, heating and refluxing extraction 1 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C 60 DEG C, relative density is the mastic of 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 3 times relative to the mixture quality obtained, and heating decoction 4 hours, filters; By filtering residue again with the water dissolution of 1 times relative to the mixture quality obtained, again heat decoction 2 hours, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.
The toxicity test of pharmaceutical composition:
1, trial drug
Choose Folium Mori 25g, Gypsum Fibrosum 6g, Radix Ophiopogonis 15g, Rhizoma Polygonati Odorati 12g, Herba Saniculae lamelligerae 17g, Periostracum Cicadae 16g, Flos Farfarae 13g, Radix Rehmanniae 32g, Rhizoma Polygonati 21g, Fructus Lycii 27g, Fructus Arctii 19g, Fructus Phyllanthi 13g, Radix Tinosporae 11g, Thallus Porphyrae 14g, Radix Glycyrrhizae 18g, Rhizoma Belamcandae 12g, Lasiosphaera Seu Calvatia 8g, Herba Portulacae 16g, Herba Galii Teneri 12g, Indigo Naturalis 13g, Flos Chrysanthemi Indici 16g and Radix Isatidis 22g mix, and is ground into powder; Added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filtering residue; Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtrate, obtaining the second filtrate; Merge twice filtrate, concentrating under reduced pressure remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.
2, test method: select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
Contrast test
Jining City in Shandong Province Canis familiaris L. plant, in January, 2013, find 180 Canis familiaris L. appearance hoarseness in various degree nearly, some sound step-downs are heavy, coarse, it is heavier that morning plays symptom, increase with activity, expectoration throat portion secretion and taking a turn for the better gradually, throat checks that visible larynx mucosa diffusivity is congested, vocal cords lose normal gloss, in pale red or kermesinus, pressing throat, reflex cough; Auscultation throat organ: have bubbling rales and laryngostenosis; Inspiratory dyspnea, body temperature raises and is diagnosed as Canis familiaris L. acute laryngitis according to above-mentioned epidemiology.
Choose the ill Canis familiaris L. 60 of making a definite diagnosis 1 years old age, 60 ill Canis familiaris L.s are divided into three groups at random, be respectively embodiment group 1, embodiment group 2 and matched group, the ill Canis familiaris L. of three groups all without significant difference, has comparability in body weight, the state of an illness etc.
Embodiment group 1, embodiment group 2 and matched group use the spray 1 of the embodiment of the present invention 1, the powder of embodiment 2 and conventional medicament to treat respectively, wherein the spray Neulized inhalation 20s of embodiment 1, every day 2 times; Continuous treatment 7 days, conventional feed of feeding; The powder of embodiment 2, by powder according in the part by weight conventional feed of 3:100, feeds 7 days continuously; Conventional medicament is that air compress pump nebuliser sucks dexamethasone aerosol 20s, every day 2 times, continuous 7d, conventional feed of feeding, continuously treatment 7 days, and result as shown in Table 1 and Table 2.
Wherein,
Effective: hoarseness, cough, inspiratory stridor, inspiratory three depressions sign all disappear, and pronunciation recovers normal, and film and vocal cords are slitted without red and swollen and congested in throat,
Take a turn for the better: hoarseness is clearly better, though cough, inspiratory stridor, inspiratory three depressions sign disappearance throat slit, film and red and swollen the having clear improvement of vocal cords are not eliminated completely,
Invalid: above-mentioned symptom alleviates without any.
Three groups, table 1 sick Canis familiaris L. therapeutic effect synopsis
Data from table 1: compared with conventional medicament, the medicine of the embodiment of the present invention 1 and 2 has advantage that is evident in efficacy, cheap, that have no side effect in treatment Canis familiaris L. acute laryngitis.
The therapeutic effect time synopsis of the sick Canis familiaris L. of three groups, table 2
Data from table 2: compared with conventional medicament, the medicine of the embodiment of the present invention 1 and 2 has evident in efficacy, rapid-action advantage in treatment Canis familiaris L. acute laryngitis.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. be used for the treatment of the pharmaceutical composition of Canis familiaris L. acute laryngitis, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: Folium Mori, Gypsum Fibrosum, Radix Ophiopogonis, Rhizoma Polygonati Odorati, Herba Saniculae lamelligerae, Periostracum Cicadae, Flos Farfarae, the Radix Rehmanniae, Rhizoma Polygonati, Fructus Lycii, Fructus Arctii, Fructus Phyllanthi, Radix Tinosporae, Thallus Porphyrae, Radix Glycyrrhizae, Rhizoma Belamcandae, Lasiosphaera Seu Calvatia, Herba Portulacae, Herba Galii Teneri, Indigo Naturalis, Flos Chrysanthemi Indici and Radix Isatidis.
2. the pharmaceutical composition being used for the treatment of Canis familiaris L. acute laryngitis according to claim 1, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Folium Mori 16-27 weight portion, Gypsum Fibrosum 5-10 weight portion, Radix Ophiopogonis 12-19 weight portion, Rhizoma Polygonati Odorati 10-15 weight portion, Herba Saniculae lamelligerae 12-22 weight portion, Periostracum Cicadae 12-20 weight portion, Flos Farfarae 10-18 weight portion, Radix Rehmanniae 25-37 weight portion, Rhizoma Polygonati 14-25 weight portion, Fructus Lycii 15-28 weight portion, Fructus Arctii 12-21 weight portion, Fructus Phyllanthi 10-17 weight portion, Radix Tinosporae 10-15 weight portion, Thallus Porphyrae 10-18 weight portion, Radix Glycyrrhizae 10-18 weight portion, Rhizoma Belamcandae 12-19 weight portion, Lasiosphaera Seu Calvatia 8-13 weight portion, Herba Portulacae 12-18 weight portion, Herba Galii Teneri 10-14 weight portion, Indigo Naturalis 9-18 weight portion, Flos Chrysanthemi Indici 10-19 weight portion and Radix Isatidis 15-25 weight portion.
3. the pharmaceutical composition being used for the treatment of Canis familiaris L. acute laryngitis according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Folium Mori 25 weight portion, Gypsum Fibrosum 6 weight portion, Radix Ophiopogonis 15 weight portion, Rhizoma Polygonati Odorati 12 weight portion, Herba Saniculae lamelligerae 17 weight portion, Periostracum Cicadae 16 weight portion, Flos Farfarae 13 weight portion, the Radix Rehmanniae 32 weight portion, Rhizoma Polygonati 21 weight portion, Fructus Lycii 27 weight portion, Fructus Arctii 19 weight portion, Fructus Phyllanthi 13 weight portion, Radix Tinosporae 11 weight portion, Thallus Porphyrae 14 weight portion, Radix Glycyrrhizae 18 weight portion, Rhizoma Belamcandae 12 weight portion, Lasiosphaera Seu Calvatia 8 weight portion, Herba Portulacae 16 weight portion, Herba Galii Teneri 12 weight portion, Indigo Naturalis 13 weight portion, Flos Chrysanthemi Indici 16 weight portion and Radix Isatidis 22 weight portion.
4. the pharmaceutical composition being used for the treatment of Canis familiaris L. acute laryngitis according to any one of claim 1-3, is characterized in that, described pharmaceutical composition also comprises the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chiritae Fimbrisepalae and Fructus Setariae Germinatus.
5. the pharmaceutical composition being used for the treatment of Canis familiaris L. acute laryngitis according to any one of claim 1-4, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Folium Mori 16-27 weight portion, Gypsum Fibrosum 5-10 weight portion, Radix Ophiopogonis 12-19 weight portion, Rhizoma Polygonati Odorati 10-15 weight portion, Herba Saniculae lamelligerae 12-22 weight portion, Periostracum Cicadae 12-20 weight portion, Flos Farfarae 10-18 weight portion, Radix Rehmanniae 25-37 weight portion, Rhizoma Polygonati 14-25 weight portion, Fructus Lycii 15-28 weight portion, Fructus Arctii 12-21 weight portion, Fructus Phyllanthi 10-17 weight portion, Radix Tinosporae 10-15 weight portion, Thallus Porphyrae 10-18 weight portion, Radix Glycyrrhizae 10-18 weight portion, Rhizoma Belamcandae 12-19 weight portion, Lasiosphaera Seu Calvatia 8-13 weight portion, Herba Portulacae 12-18 weight portion, Herba Galii Teneri 10-14 weight portion, Indigo Naturalis 9-18 weight portion, Flos Chrysanthemi Indici 10-19 weight portion, Radix Isatidis 15-25 weight portion, Radix Astragali 12-20 weight portion, Radix Codonopsis 12-18 weight portion, Radix Angelicae Sinensis 8-16 weight portion, Rhizoma Chiritae Fimbrisepalae 3-9 weight portion and Fructus Setariae Germinatus 8-17 weight portion.
6. the pharmaceutical composition being used for the treatment of Canis familiaris L. acute laryngitis according to any one of claim 1-5, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Folium Mori 25 weight portion, Gypsum Fibrosum 6 weight portion, Radix Ophiopogonis 15 weight portion, Rhizoma Polygonati Odorati 12 weight portion, Herba Saniculae lamelligerae 17 weight portion, Periostracum Cicadae 16 weight portion, Flos Farfarae 13 weight portion, the Radix Rehmanniae 32 weight portion, Rhizoma Polygonati 21 weight portion, Fructus Lycii 27 weight portion, Fructus Arctii 19 weight portion, Fructus Phyllanthi 13 weight portion, Radix Tinosporae 11 weight portion, Thallus Porphyrae 14 weight portion, Radix Glycyrrhizae 18 weight portion, Rhizoma Belamcandae 12 weight portion, Lasiosphaera Seu Calvatia 8 weight portion, Herba Portulacae 16 weight portion, Herba Galii Teneri 12 weight portion, Indigo Naturalis 13 weight portion, Flos Chrysanthemi Indici 16 weight portion, Radix Isatidis 22 weight portion, the Radix Astragali 18 weight portion, Radix Codonopsis 15 weight portion, Radix Angelicae Sinensis 13 weight portion, Rhizoma Chiritae Fimbrisepalae 5 weight portion and Fructus Setariae Germinatus 9 weight portion.
7. the pharmaceutical composition being used for the treatment of Canis familiaris L. acute laryngitis according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is spray, and its preparation method comprises the following steps:
A, take all raw medicinal materials in described ratio, add relative to the mixture quality 3-5 obtained water water soaking 3-10 hour doubly, after intense fire boils, use slow fire instead and decoct 30-50 minute slowly, decoct 3 times, merge decoction liquor and filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;
B, the medicinal residues of step a are added 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, filters, concentrated, 80-160 order filters, 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;
C, extractum 1 and extractum 2 are mixed, thin up obtains aqueous premix;
D, under explosion-proof environment condition, in tank with cover, add aqueous premix 8-10 dehydrated alcohol doubly, then slowly stir, slowly add the aqueous premix obtained in step c;
E, continue slowly to add aqueous premix 1-2 doubly 99.6% glycerol, stir until obtain limpid solution;
F, with 6 μm, and the filter cartridge type filter of ethanol tolerant it to be filtered, and be sent to filling machine, canned in 100ml slush moulding vial with can packing machine; After sterilizing gland, temperature controls, at 25 DEG C, to pour propellant iso-butane by upper valve; Net volume after valve is packaged is 80ml.
8. the pharmaceutical composition being used for the treatment of Canis familiaris L. acute laryngitis according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:
The first step, Folium Mori, Radix Ophiopogonis, Rhizoma Polygonati Odorati, Herba Saniculae lamelligerae, Periostracum Cicadae, Flos Farfarae, the Radix Rehmanniae, Rhizoma Polygonati and Fructus Lycii are mixed in described ratio, with being the soak with ethanol of 85% ~ 95% relative to the determining alcohol of 3 ~ 5 times of mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again by the soak with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Fructus Arctii, Fructus Phyllanthi and Radix Tinosporae are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 80 ~ 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.
9. the preparation method being used for the treatment of the pharmaceutical composition of Canis familiaris L. acute laryngitis as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is spray, and its preparation method comprises the following steps:
A, take all raw medicinal materials in described ratio, add relative to the mixture quality 3-5 obtained water water soaking 3-10 hour doubly, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, decoct 3 times, merge decoction liquor to filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;
B, the medicinal residues of step a are added 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, filters, concentrated, 80-160 order filters, 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;
C, extractum 1 and extractum 2 are mixed, thin up obtains aqueous premix;
D, under explosion-proof environment condition, in tank with cover, add aqueous premix 8-10 dehydrated alcohol doubly, then slowly stir, slowly add the aqueous premix obtained in step c;
E, continue slowly to add aqueous premix 1-2 doubly 99.6% glycerol, stir until obtain limpid solution;
F, with 6 μm, and the filter cartridge type filter of ethanol tolerant it to be filtered, and be sent to filling machine, canned in 100ml slush moulding vial with can packing machine; After sterilizing gland, temperature controls, at 25 DEG C, to pour propellant iso-butane by upper valve; Net volume after valve is packaged is 80ml.
10. the preparation method being used for the treatment of the pharmaceutical composition of Canis familiaris L. acute laryngitis as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:
The first step, Folium Mori, Radix Ophiopogonis, Rhizoma Polygonati Odorati, Herba Saniculae lamelligerae, Periostracum Cicadae, Flos Farfarae, the Radix Rehmanniae, Rhizoma Polygonati and Fructus Lycii are mixed in described ratio, with being the soak with ethanol of 85% ~ 95% relative to the determining alcohol of 3 ~ 5 times of mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again by the soak with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Fructus Arctii, Fructus Phyllanthi and Radix Tinosporae are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 80 ~ 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.
CN201410750360.3A 2014-12-10 2014-12-10 Pharmaceutical composition for treating acute laryngitis of dogs and preparation method thereof Pending CN104352778A (en)

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