CN104721767A - Chinese medicinal composition for treatment of children cough and preparation method thereof - Google Patents
Chinese medicinal composition for treatment of children cough and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for treatment of children cough and a preparation method thereof. The composition is prepared from the following raw materials: Cinnamomum cassia Presl, atractylodes lancea, Semen Armeniacae Amarum., rhizoma zingiberis, Schisandra chinensis, Semen Sinapis, perilla, Radix Glycyrrhizae Preparata, Rhizoma Pinellinae Praeparata, and Aster tataricus. The invention also provides a preparation method of the Chinese medicinal composition for treatment of children cough. The composition provided by the invention has the advantages of definite curative effect, good safety and no side effect in treatment of children cough and respiratory tract infection.
Description
Technical field
The present invention relates to pharmaceutical sanitary field, be specifically related to a kind of Chinese medicine composition for the treatment of infantile cough and preparation method thereof.
Background technology
Cough is one of common symptom of lung pattern disease, begins to be loaded in "Nei Jing".Children's is more weak because of health, easily because exopathogen invades lungs or visceral dysfunction causes impairment of dispersing and descending function of the lung, abnormal rising of lung-QI.From modern medical theory, cough as a kind of important defense mechanism, the pharyngeal and whole viscous secretion of respiratory tract and the harmful substance of suction and foreign body can be removed by cough.From physiology, coughing to the scavenging action of air flue is useful when excess secretion, and frequently violent cough can affect the breathing of patient and the function of heart.Very long history development procedure be experienced by the understanding of " cough ", " ten cough " from " visceral cough " of "Nei Jing" to Sui's Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases ", i.e. wind, cold, , the heart, liver, spleen, kidney, gallbladder, faint and to cough etc. ten kinds: from Au element to cough pathogenesis and Coryza Treated by Syndrome Differentiation, period of Ming and Qing are with Wang Kentang, Zhao Xianke is that the doctor of representative is to the further investigated of cough etiology and pathogenesis, to modern Application high-tech means to cough physiology and pathomechanism profound level dissect, and by means of the new experimental apparatus emerged in an endless stream and experimental technique, then more deep to its research, thoroughly.
Western medical treatment is coughed, generally based on antiinflammatory.As caused cough after flu, except antiviral cures cold, the many and same use of antibiotic, controls upper respiratory tract and bronchitis rapidly; Cough recurrent exerbation also accompanies asthma person, except infection, also uses spasmolytic anti-asthmatic, as peace tea alkali and salbutamol, to remove tracheospasm simultaneously; Because of the cough that rhinitis, sinusitis, tonsillitis etc. cause, mostly with caused by trachea concurrent infection, therefore can for the topical therapeutic of naso-pharynageal disease when treatment, as taken out pus to the puncture of sinusitis, to tonsillitis and the Fructus Persicae Corpectomy etc. of enlargement.About the typing of cough, from doctor trained in Western medicine angle, be divided into larynx source property, drug induccd and allergic cough etc.
The traditional Chinese medical science is thought, the cause of disease of cough, and one is the heresy of diseases caused by exogenous pathogenic factor six climate exopathogens, and two is pathogenic QIs in the body of internal organs, all can cause that lung qi is unclear to be lost in a surname respectful, compels gas superinverse and coughs.No matter diseases caused by exogenous pathogenic factor or the cough caused by internal injury, all involves lungs by sick, by lung qi unclear lose respectful in a surname caused by, therefore " Jing Yue's complete work cough " is said: " though cough demonstrate,prove many, pneumonopathy nothing but." " Medicine Comprehended " point out: " lung body belongs to gold, kowtows and does not ring, the heresy of wind and cold heat-damp in summer dryness-fire six climate exopathogens such as Zhong Ran, Zhong Fei, and from then ringing of hitting outward, labor is for feelings will, and fire then also the ringing from inside fire attack of fighting processed by diet." point out cough to be that inside and outside pathogenic factor violates lung, lungs reach produced a kind of pathological reaction outside eliminating evil.Exogenous cough and endogenous cough also can influence each other as disease, and the sick then domination of pathogen of a specified duration transfers to weakened body resistance.Exogenous cough's such as delay mistake is controlled, and evil impairing the lung gas, more easily feels evil repeatedly, and causes cough and do repeatly, transfers endogenous cough to; Lungs are ill, weakened defensive QI, are subject to exopathogen and cause or increase the weight of, particularly evident when climate change especially.Of a specified duration then empty from real-turn, lungs are weak, deficiency of YIN leading to consumption of QI.It can thus be appreciated that though cough has dividing of diseases caused by exogenous pathogenic factor, internal injury, both again can reciprocal causation sometimes.
Due to the particularity of children's's health, medicine for treatment need consider consideration.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of infantile cough;
Another object of the present invention is to provide a kind of Chinese medicine composition preparation method for the treatment of infantile cough.
The object of the invention is by following technical scheme realize:
The Chinese medicine composition for the treatment of infantile cough of the present invention is prepared from by the raw material containing following weight portion:
Ramulus Cinnamomi 10-18 part, Rhizoma Atractylodis 5-15 part, Semen Armeniacae Amarum 5-15 part, Rhizoma Zingiberis 5-15 part, Fructus Schisandrae Chinensis 5-15 part, Semen Sinapis Albae 10-18 part, Fructus Perillae 5-15 part, Radix Glycyrrhizae Preparata 2-8 part, Rhizoma Pinelliae Preparatum 5-15 part, Radix Asteris 10-18 part.
Preferably, be prepared from by the raw material containing following weight portion:
Ramulus Cinnamomi 12-16 part, Rhizoma Atractylodis 8-12 part, Semen Armeniacae Amarum 8-12 part, Rhizoma Zingiberis 8-12 part, Fructus Schisandrae Chinensis 8-12 part, Semen Sinapis Albae 12-16 part, Fructus Perillae 8-12 part, Radix Glycyrrhizae Preparata 3-8 part, Rhizoma Pinelliae Preparatum 8-12 part, Radix Asteris 12-16 part.
More preferably, be prepared from by the raw material containing following weight portion:
Ramulus Cinnamomi 15 parts, Rhizoma Atractylodis 10 parts, Semen Armeniacae Amarum 10 parts, Rhizoma Zingiberis 10 parts, Fructus Schisandrae Chinensis 10 parts, Semen Sinapis Albae 15 parts, Fructus Perillae 10 parts, Radix Glycyrrhizae Preparata 5 parts, Rhizoma Pinelliae Preparatum 10 parts, Radix Asteris 15 parts.
Below crude drug source of the present invention:
Ramulus Cinnamomi: (formal name used at school: Cinnamomum cassia Presl), has another name called beautiful osmanthus, Cortex cinnamomi japonici (Ramulus Cinnamomi) etc., belongs to Ranales, the medium megaphanerophyte of Lauraceae.Its nature and flavor are pungent, sweet, enter liver,kidney,spleen, cure mainly the conventional drugs for dispelling internal cold of interior cold, there is effect of complement sun, promoting blood circulation, warming the spleen and stomach, normal and invigorating the liver and kidney medicine, fill blood medicine compatibility, treatment insufficiency of kidney-YANG, decline of the fire from the gate of life, cold extremities faint pulse, treat coldness and pain in the epigastrium, arthralgia due to cold lumbago with other drugs for dispelling internal cold compatibility, has the effect of significantly analgesia and anti-cancer and cancer-preventing.
Rhizoma Atractylodis: the dry rhizome that (formal name used at school: Atractylodes lancea) is Atractylodes lancea (Thunb.) DC. or Atractylis chinensis.Have drying damp and strengthening spleen, effect of wind-damp dispelling.Cure mainly retention of dampness in middle-JIAO, anemofrigid-damp arthralgia, foot swelling and pain in knee, flaccidity is soft unable, nyctalopia nyctalopia." pearl sac " day: " stomach invigorating can pacify spleen, non-this of all damp-edema can not remove." Compendium of Material Medica says: " control damp-phlegm prolonged fluid-retention ... and spleen wets dirty, turbid drop leukorrhagia, slides and rushes down hemorrhoidal hamorrhage." " Newly Revised Canon of Materia Medica " claim it can " diuresis ".
Semen Armeniacae Amarum refers to Semen Armeniacae Amarum, Semen Armeniacae Amarum of also grieving.Latin literary fame: Semen Armeniacae Amarum. is rosaceous plant Prunus armeniaca L.var.ansu Maxim..Bitter, tepor, slightly poisonous.Return liver, large intestine channel.Sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.For cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, dryness of the intestine constipation.Be good at falling lung qi to relieving asthma, control breathing with cough of excess of the lung.
Rhizoma Zingiberis is the dry rhizome of zingiber Zingiber officinale Rosc..[acrid in the mouth, hot in nature.Return spleen, stomach, the heart, lung meridian.Warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention.Cure mainly coldness and pain in the epigastrium, vomit, have loose bowels, YANG-depletion faint inverse, cold fluid-retention is breathed with cough, arthralgia due to cold-dampnes.
Fructus Schisandrae Chinensis: formal name used at school: Schisandra chinensis), call profound and, meeting and, five Fructus Armeniacae Mumes, Fructus Zanthoxyli Plansipini, strong taste, the five tastes etc., Tang etc. " Newly Revised Canon of Materia Medica " carry " the sweet acid of five tastes skin and flesh, arduous in core, have saline taste ", therefore have the name of Fructus Schisandrae Chinensis.List in Sheng Nong's herbal classic the earliest top grade, herbal function is the power of strengthening by means of tonics, and medical value is high, and bifendate, Bicyclol have hepatoprotective function.
Semen Sinapis Albae: another name hot food, the dry mature seed of Latin literary fame Semen sinapis. 1 year or biennial plant Caulis et Folium Sinapis albee Sinapis alba L.." must book on Chinese herbal medicine be joined ": " enter meridian of Hand-TAI YIN." warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving.Cure mainly and reduce phlegm by drink; Mass dissipating and swelling eliminating.Main cough with asthma abundant expectoration; Fullness in the chest and hypochondriac pain; Numb limbs and tense tendons; Arthralgia; Multiple abscess caused by damp-phlegm; Carbuncle of yin nature toxic swelling.Control acute mastitis, breast carcinoma, mammary gland pain, tuberculosis, phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, regurgitation is vomitted, aphasia due to apoplexy, and limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.Breath with cough for cold-phlegm, distending pain in the chest and hypochondrium, the stagnant meridians of expectorant, joint numbness, pain, phlegm-damp oozing in the body, carbuncle of yin nature toxic swelling.
Fructus Perillae: another name Fructus Perillae, FRUCTUS PERILLAE.For the dry mature fruit of labiate Folium Perillae Perilla frutescens (L.) Britt..Pungent, temperature.Return lung, large intestine channel.Function cures mainly sending down the abnormal ascending QI expectorant, relieving cough and asthma, loosening bowel to relieve constipation.QI rising in reverse order is stopped up, cough and asthma, dryness of the intestine constipation for expectorant.
Radix Glycyrrhizae Preparata is the Root and Rootstock of pulse family glycyrrhiza genus Radix Glycyrrhizae Glycyrrhiza uralensis Fisch..Wild product are excavated autumn, and cultivation product, are excavated after 3 ~ 4 years in the fall in sowing, remove residual stem, dry respectively by thickness.Extracting liquorice sheet, adds cooked Mel and boiled water a little, mixes thoroughly, slightly vexed, put in pot with slow fire fry to become buff, tack-free be degree, taking-up cools.
Rhizoma Pinelliae Preparatum is the Preparation process product of the tuber of the aroid Rhizoma Pinelliae (Pinellia ternata (Thunb) Breit.).Pungent, warm.Return spleen, stomach, lung meridian.Drying dampness to eliminate phlegm.For dry laryngopharynx, abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache.
Radix Asteris, another name: Radix Asteris.For the dry root and rhizome of feverfew Radix Asteris Aster tataricus L. f..Warm in nature, bitter in the mouth, pungent.Nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm.Breath with cough for abundant expectoration, new chronic cough is coughed, chronic cough hemoptysis.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and the method is the ethanol extraction adopting water extraction or 40-80% concentration expressed in percentage by volume.Concrete preparation method is as follows:
Scheme one: get whole 10 taste medical materials, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.10-1.25, obtains active component.
Scheme two: get whole 10 taste medical materials, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.05-1.20, add ethanol, make alcohol content be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.
Scheme three: get whole 10 taste medical materials, with 40-80% alcohol reflux 2-3 time, each ethanol consumption be the 4-10 of medical material total amount doubly, extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 60-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.
The Chinese medicine composition for the treatment of infantile cough of the present invention, with pharmaceutically acceptable carrier combination, can make various common dosage forms, as tablet, granule, capsule, syrup etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.
Correctives: sucrose, monosaccharide, aromatic etc.
Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.
Method 1: tablet
Get one of scheme one to scheme three gained active component, add tablet and commonly use adjuvant, production method is prepared into Tablets routinely.
Above-mentioned tablet is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 2: granule
Get one of scheme one to scheme three gained active component, add granule and commonly use adjuvant, production method is prepared into granule of the present invention routinely.
Above-mentioned granule is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent or whole.
Method 3: capsule
Get one of scheme one to scheme three gained active component, add capsule and commonly use adjuvant, production method is prepared into granule of the present invention routinely.
Above-mentioned capsule is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 4: syrup
Get one of scheme one to scheme three gained active component, add syrup and commonly use adjuvant, production method is prepared into syrup of the present invention routinely.
Above-mentioned syrup is commonly used adjuvant and is comprised one of correctives, antiseptic, cosolvent or whole.
Method 5: mixture
Get one of scheme one to scheme three gained active component, add mixture and commonly use adjuvant, production method is prepared into mixture of the present invention routinely.
Above-mentioned mixture is commonly used adjuvant and is comprised one of correctives, antiseptic or whole.
According to theory of Chinese medical science, cough generally has diseases caused by exogenous pathogenic factor and internal injury two kinds of causes of disease to cause.The applicant is reference modern pharmacological research achievement on the basis of research tradition tcm syndrome differentiation and treatment, and combine through test for many years, multiple formulations is screened, have found lower Chinese medicine composition infantile cough and upper respiratory tract infection being had to better therapeutic effect that cooperatively interacts.
A kind of Chinese medicine composition for the treatment of infantile cough provided by the invention has the following advantages:
1, compositions provided by the invention is safe and effective, is 96% to infantile cough clinical effective rate, Be very effective.Especially in the completeness of cough-relieving, after cough-relieving of the present invention not easily repeatedly, Western medicine usually can only temporary transient antitussive, and easily repeatedly, Drug therapy infantile cough of the present invention is inside and outside double to be controlled, and recovery from illness thoroughly.
2, Traditional Chinese medicine composition formula of the present invention is rationally innovated, and production cost is low, technique is simple.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.
Embodiment 1 syrup
Get Ramulus Cinnamomi 15g, Rhizoma Atractylodis 10g, Semen Armeniacae Amarum 10g, Rhizoma Zingiberis 10g, Fructus Schisandrae Chinensis 10g, Semen Sinapis Albae 15g, Fructus Perillae 10g, Radix Glycyrrhizae Preparata 5g, Rhizoma Pinelliae Preparatum 10g, Radix Asteris 15g.By above-mentioned 10 taste medical materials, extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, and the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10.In extractum, add syrup adjuvant sucrose, sorbic acid, water stirs, obtained syrup.
Embodiment 2 tablet
Get Ramulus Cinnamomi 12g, Rhizoma Atractylodis 8g, Semen Armeniacae Amarum 8g, Rhizoma Zingiberis 8g, Fructus Schisandrae Chinensis 8g, Semen Sinapis Albae 12g, Fructus Perillae 8g, Radix Glycyrrhizae Preparata 3g, Rhizoma Pinelliae Preparatum 8g, Radix Asteris 12g.By above-mentioned 10 taste medical materials, with 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid, filters, and when filtrate concentrates 60 DEG C, relative density is the extractum of 1.25, add supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
Embodiment 3 mixture
Get Ramulus Cinnamomi 16g, Rhizoma Atractylodis 12g, Semen Armeniacae Amarum 12g, Rhizoma Zingiberis 12g, Fructus Schisandrae Chinensis 12g, Semen Sinapis Albae 16g, Fructus Perillae 12g, Radix Glycyrrhizae Preparata 8g, Rhizoma Pinelliae Preparatum 12g, Radix Asteris 16g.By above-mentioned 10 taste medical materials, extracting in water 3 times, three amount of water are equivalent to 12 times, 8 times, 6 times of medical material gross weight respectively, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.20, adds ethanol, makes alcohol content be 40%, leave standstill 24 hours, filter, it is the extractum of 1.10 that filtrate is concentrated into relative density when filtrate is concentrated into 70 DEG C, adds 3 times that purified water ad pond om is medical material gross weight, fill, obtains mixture of the present invention.
Add syrup adjuvant sucrose, ethyl ester, water, vegetable oil stir, obtained syrup.
Embodiment 4 tablet
Get Ramulus Cinnamomi 10g, Rhizoma Atractylodis 5g, Semen Armeniacae Amarum 5g, Rhizoma Zingiberis 5g, Fructus Schisandrae Chinensis 5g, Semen Sinapis Albae 10g, Fructus Perillae 50g, Radix Glycyrrhizae Preparata 2g, Rhizoma Pinelliae Preparatum 5g, Radix Asteris 10g, by above-mentioned 10 taste medical material alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, extraction time is respectively 4 hours, 3 hours, merge extractive liquid, filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, add supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
Embodiment 5 capsule
Get Ramulus Cinnamomi 18g, Rhizoma Atractylodis 15g, Semen Armeniacae Amarum 15g, Rhizoma Zingiberis 15g, Fructus Schisandrae Chinensis 15g, Semen Sinapis Albae 18g, Fructus Perillae 15g, Radix Glycyrrhizae Preparata 8g, Rhizoma Pinelliae Preparatum 15g, Radix Asteris 18g.By above-mentioned 10 taste medical materials, extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid, filters, and when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.25, add supplementary product starch, ethanol, dextrin, magnesium stearate, incapsulate shell, obtained capsule.
Embodiment 6 granule
Get Ramulus Cinnamomi 12g, Rhizoma Atractylodis 15g, Semen Armeniacae Amarum 8g, Rhizoma Zingiberis 15g, Fructus Schisandrae Chinensis 15g, Semen Sinapis Albae 12g, Fructus Perillae 15g, Radix Glycyrrhizae Preparata 8g, Rhizoma Pinelliae Preparatum 15g, Radix Asteris 16g.By above-mentioned 10 taste medical materials, extracting in water 2 times, each amount of water is equivalent to 12 times, 10 times of medical material gross weight respectively, each extraction time is respectively 3 hours, 2 hours, merge extractive liquid, filters, it is the clear paste of 1.05 that filtrate is concentrated into relative density at 80 DEG C, add ethanol, make alcohol content be 70%, leave standstill 12 hours, filter, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.25, adds adjuvant Icing Sugar, starch, dextrin, ethanol, obtained granule.
Embodiment 7 powder
Take Ramulus Cinnamomi 16g, Rhizoma Atractylodis 15g, Semen Armeniacae Amarum 12g, Rhizoma Zingiberis 15g, Fructus Schisandrae Chinensis 15g, Semen Sinapis Albae 18g, Fructus Perillae 8g, Radix Glycyrrhizae Preparata 8g, Rhizoma Pinelliae Preparatum 15g, Radix Asteris 10g, medical material cleans, pulverize, cross 80-100 mesh sieve, obtain powder of the present invention.
Embodiment 8
Granule prepared by the embodiment of the present invention 6, the pediatric patient giving to cough is oral, and each 1 bag, every day 3 times, clinical data is as follows:
| Disease disease classification | Disease number of cases | Disease year calendar | Treatment time | Efficiently individual quantity | Total effective rate |
| Infantile cough | 100 people | 3-10 days | 2-10 days | 96 people | 96% |
Clinical treatment outcome shows: the present invention has extremely significant effect to infantile cough, especially in the completeness of cough-relieving, after cough-relieving of the present invention not easily repeatedly, Western medicine usually can only temporary transient antitussive, easily repeatedly, Drug therapy infantile cough of the present invention is inside and outside double to be controlled, and recovery from illness thoroughly.
Embodiment 9
Liu, man, 5 years old, coughs 3 days, abundant expectoration, and severe is had a stuffy nose.Body is looked into: without heating, and two pulmonary respiration sound increases thick, without rale.Examine as cough due to wind and cold.Give the present embodiment 1 syrup, acutely cough in the evening on the same day of taking medicine, and spits, and cough in second day obviously reduces, and has a stuffy nose, transference cure of coughing after 3 days, and have no recurrence after one week, is judged as recovery from illness.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (8)
1. treat a Chinese medicine composition for infantile cough, it is characterized in that it is prepared from by the raw material comprising following weight portion: Ramulus Cinnamomi 10-18 part, Rhizoma Atractylodis 5-15 part, Semen Armeniacae Amarum 5-15 part, Rhizoma Zingiberis 5-15 part, Fructus Schisandrae Chinensis 5-15 part, Semen Sinapis Albae 10-18 part, Fructus Perillae 5-15 part, Radix Glycyrrhizae Preparata 2-8 part, Rhizoma Pinelliae Preparatum 5-15 part, Radix Asteris 10-18 part.
2. the Chinese medicine composition for the treatment of infantile cough as claimed in claim 1, is characterized in that it is prepared from by the raw material comprising following weight portion: Ramulus Cinnamomi 12-16 part, Rhizoma Atractylodis 8-12 part, Semen Armeniacae Amarum 8-12 part, Rhizoma Zingiberis 8-12 part, Fructus Schisandrae Chinensis 8-12 part, Semen Sinapis Albae 12-16 part, Fructus Perillae 8-12 part, Radix Glycyrrhizae Preparata 3-8 part, Rhizoma Pinelliae Preparatum 8-12 part, Radix Asteris 12-16 part.
3. the Chinese medicine composition for the treatment of infantile cough as claimed in claim 1, is characterized in that it is prepared from by the raw material comprising following weight portion: Ramulus Cinnamomi 15 parts, Rhizoma Atractylodis 10 parts, Semen Armeniacae Amarum 10 parts, Rhizoma Zingiberis 10 parts, Fructus Schisandrae Chinensis 10 parts, Semen Sinapis Albae 15 parts, Fructus Perillae 10 parts, Radix Glycyrrhizae Preparata 5 parts, Rhizoma Pinelliae Preparatum 10 parts, Radix Asteris 15 parts.
4. the Chinese medicine composition as described in claim 1-3 any one, is characterized in that its active component adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
5. Chinese medicine composition as claimed in claim 4, it is characterized in that its active component is prepared from by the following method: get whole 10 taste medical materials, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.10-1.25, obtains active component.
6. Chinese medicine composition as claimed in claim 4, it is characterized in that its active component is prepared from by the following method: get whole 10 taste medical materials, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.05-1.20, adds ethanol, makes alcohol content be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.
7. Chinese medicine composition as claimed in claim 4, it is characterized in that its active component is prepared from by the following method: get whole 10 taste medical materials, with 40-80% alcohol reflux 2-3 time, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 60-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.
8. treat a Chinese medicine composition for infantile cough, comprise acceptable carrier in the Chinese medicine composition of the treatment infantile cough any one of claim 1-3 and pharmaceuticals industry.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104958747A (en) * | 2015-08-03 | 2015-10-07 | 马丽 | Traditional Chinese medicine composition for treating infantile cough |
| EP3787658A4 (en) * | 2018-04-30 | 2022-03-30 | Chong Kun Dang Pharmaceutical Corp. | A composition with antitussive and expectoration activities comprising an extract of atractylodis rhizoma alba and schisandrae fructus |
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| CN102305839A (en) * | 2007-09-26 | 2012-01-04 | 北京亚东生物制药有限公司 | Detection method of traditional Chinese medicine composition for freeing lung and relieving asthma |
| KR20120043426A (en) * | 2010-10-26 | 2012-05-04 | 주식회사 벤스랩 | Functional composition and health food using the same |
| CN103142949A (en) * | 2013-02-21 | 2013-06-12 | 成都科创佳思科技有限公司 | Chinese patent drug for treating infantile asthma |
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2013
- 2013-12-20 CN CN201310705332.5A patent/CN104721767A/en active Pending
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| CN102305839A (en) * | 2007-09-26 | 2012-01-04 | 北京亚东生物制药有限公司 | Detection method of traditional Chinese medicine composition for freeing lung and relieving asthma |
| KR20120043426A (en) * | 2010-10-26 | 2012-05-04 | 주식회사 벤스랩 | Functional composition and health food using the same |
| CN103142949A (en) * | 2013-02-21 | 2013-06-12 | 成都科创佳思科技有限公司 | Chinese patent drug for treating infantile asthma |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104958747A (en) * | 2015-08-03 | 2015-10-07 | 马丽 | Traditional Chinese medicine composition for treating infantile cough |
| EP3787658A4 (en) * | 2018-04-30 | 2022-03-30 | Chong Kun Dang Pharmaceutical Corp. | A composition with antitussive and expectoration activities comprising an extract of atractylodis rhizoma alba and schisandrae fructus |
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