CN106110156A

CN106110156A - A kind of cream side for chronic obstructive pulmonary disease, preparation method and its usage

Info

Publication number: CN106110156A
Application number: CN201610571919.5A
Authority: CN
Inventors: 李风森
Original assignee: Hospital Of Traditional Chinese Medicine Affiliated To Xinjiang Medical University
Current assignee: Hospital Of Traditional Chinese Medicine Affiliated To Xinjiang Medical University
Priority date: 2016-07-19
Filing date: 2016-07-19
Publication date: 2016-11-16

Abstract

The invention belongs to field of traditional Chinese, it is provided that a kind of cream side for chronic obstructive pulmonary disease, preparation method and its usage.Described cream side includes Colla Corii Asini and crude drug, unique compatibility through this prescription, each medicine in crude drug is not only able to play effect of original medicine, after combination, its curative effect can further be strengthened simultaneously, can effectively alleviate the expectoration that chronic obstructive pulmonary disease causes breathe hard, the symptom such as the uncomfortable in chest and dyspnea of panting, improve the immunity of patient simultaneously, reduce the recurrence of the state of an illness and increase the weight of, thus delay and stop the development of the state of an illness, improve the life quality of patient.The composite can be widely applied to the expectoration that chronic obstructive pulmonary disease causes breathe hard, the symptom such as the uncomfortable in chest and dyspnea of panting.

Description

A kind of cream side for chronic obstructive pulmonary disease, preparation method and its usage

Technical field

The present invention relates to tcm field, in particular to a kind of cream side for chronic obstructive pulmonary disease, preparation Method and application thereof.

Background technology

Cream side, is again unguentum, runs after fame with its dosage form, belongs to ball in the traditional Chinese medical science, scattered, cream, pellet, wine, dew, soup, eight kinds of dosage forms of ingot One of.In theory of Chinese medical science, cream side for oral administration is a kind of patent medicine with high-grade nutrient tonic effect and Prevention effect.Cream side Typically it is made up of the Chinese medicine about 20 tastes, after dense decocting, mixes adjuvant and a kind of stiff shape of making is semi-fluid or freeze shape dosage form. There is good tonic effect, clinic is widely used for section's illness and the serious diseases such as inside and outside, woman, youngster, the injury of the bone, eye ear mouth and nose Rear body void person.

Chronic obstructive pulmonary disease (COPD), is called for short chronic obstructive pulmonary disease, and severe patient is commonly called as again " emphysema ", is that one has air-flow Block the chronic bronchitis of feature, be the common chronic disease that can be further development of pulmonary heart disease and respiratory failure.Chronic resistance Plug property lung disease is relevant with the abnormal inflammatory reaction that harmful gas and deleterious particle cause, and disability rate and case fatality rate are the highest, the whole world More than 40 years old sickness rate up to 9%～10%.In China, this disease mainly shows as chronic cough, coughs up phlegm clinically, enters Row uncomfortable in chest out of breath, obstructive dysfunction of pulmonary ventilation is shown in pulmonary ventilation function detection.Patients with Chronic Obstructive Pulmonary Disease often disease Feelings increase the weight of year by year, and severe patient can occur respiratory failure, are the commonly encountered diseases of a kind of serious harm human health, frequently-occurring disease.

From the point of view of from theory of Chinese medical science, chronic obstructive pulmonary disease belongs to the category of " pulmonary distension ", refers to multiple chronic pulmonary system disease Suffering from recurrent exerbation, protracted course of disease, lung spleen kidney three deficiency of five ZANG-organs damages, thus it is stagnant to cause lung qi to be stopped up, deficient airway, and breast bears distension not hold back Fall.Patients with chronic obstructive pulmonary disease uses Chinese medicine to become focus in recent years, its effectiveness and safety Property tentatively obtain clinical certification.According to " deficiency syndrome should be treated by tonifying method ", the principle of " radical treatment in chronic case ", mainly take strengthening the body resistance at stable phase Method, on tcm clinical practice use cream side treatment chronic obstructive pulmonary disease be comparatively ideal selection.

In view of this, the special proposition present invention.

Summary of the invention

The first object of the present invention is to provide the cream side of a kind of chronic obstructive pulmonary disease, described cream side for oral administration to have Effect alleviate the expectoration that causes of chronic obstructive pulmonary disease breathe hard, the symptom such as the uncomfortable in chest and dyspnea of panting, improve patient simultaneously Immunity, reduce the recurrence of the state of an illness and increase the weight of, thus delay and stop the development of the state of an illness, improve the life quality of patient.

The second object of the present invention is to provide the preparation method of the cream side of a kind of described chronic obstructive pulmonary disease, logical Crossing the cream side of the chronic obstructive pulmonary disease that this preparation method is prepared, concentrating degree is high, and mouthfeel is also preferable, at utmost retains The medicinal efficacy of each medical material.

The third object of the present invention is to provide the purposes of the cream side of a kind of chronic obstructive pulmonary disease, and the present invention provides The expectoration that cream side causes for chronic obstructive pulmonary disease breathes hard, it is uncomfortable in chest to pant and the disease such as dyspnea has significantly treatment Effect.

The described cream side for chronic obstructive pulmonary disease, including Colla Corii Asini and crude drug, wherein, described crude drug includes The medical material of following weight portion: Radix Codonopsis 10～60 parts, the Rhizoma Atractylodis Macrocephalae 10～60 parts, Rhizoma Atractylodis 10～60 parts, Poria 10～60 parts, Semen Coicis 10 ～60 parts, Herba Ephedrae 5～30 parts, Semen Armeniacae Amarum 5～15 parts, Cortex Magnoliae Officinalis 10～60 parts, Bulbus Fritillariae Uninbracteatae 10～30 parts, Radix Platycodonis 10～30 parts, Radix Asteris 10 ～30 parts, Flos Farfarae 10～30 parts, Pericarpium Citri Reticulatae 10～30 parts, the Rhizoma Pinelliae 10～30 parts, Fructus Psoraleae 10～30 parts, Fructus Lycii 10～30 Part, Fructus Ligustri Lucidi 10～30 parts, Fructus Perillae 10～30 parts, Fructus Amomi 10～30 parts, Fructus Amomi Rotundus 10～30 parts, Cortex Cinnamomi 10～30 parts, Fructus Jujubae 10～60 parts, Radix Scutellariae 10～30 parts, Radix Glycyrrhizae Preparata 10～30 parts, Fructus Tritici Levis 10～30 parts, Herba Schizonepetae 10～30 parts, Radix Saposhnikoviae 10～30 Part, the Radix Astragali 10～60 parts, Semen Persicae 10～30 parts, Radix Paeoniae Rubra 10～30 parts, Herba Leonuri 10～30 parts and Fructus Crataegi 10～30 parts.

The pharmacology of composition used by the present invention and nature,taste and action:

Radix Codonopsis: for traditional Chinese medical science tradition tonic, have invigorating the spleen and replenishing QI, stomach function regulating promotes the production of body fluid and effect of expelling phlegm for arresting cough, for spleen Empty anorexia and loose stool, myasthenia of limbs, cardiopalmus, breathe hard, xerostomia, spontaneous perspiration and proctoptosis.

In the present invention, the typical but non-limiting content of described Radix Codonopsis is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 Part, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 Part, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts, 56 parts, 57 parts, 58 parts, 59 parts or 60 Part.

The Rhizoma Atractylodis Macrocephalae: be distributed mainly on the mountain area wetlands such as Sichuan, Yunnan, Guizhou.The Rhizoma Atractylodis Macrocephalae belongs to herbaceos perennial, the nice and cool gas of happiness Wait, be used as medicine with rhizome, there is multinomial medicinal function.The Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect, is used for Insufficiency of the spleen lack of appetite, abdominal distention has loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.

In the present invention, the typical but non-limiting content of the described Rhizoma Atractylodis Macrocephalae is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 Part, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 Part, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts, 56 parts, 57 parts, 58 parts, 59 parts or 60 Part.

Rhizoma Atractylodis: for Compositae [WTBX herbaceos perennial.Rhizoma Atractylodis are used as medicine with root stock, for activating the spleen medicine, nature and flavor hardship Wen Xin Strong, there is dampness, change turbid and effect of pain relieving, for abdominal distention, have loose bowels, edema, rheumatic arthralgia, tinea pedis flaccidity and wind and cold sense Emit.

In the present invention, the typical but non-limiting content of described Rhizoma Atractylodis is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 Part, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 Part, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts, 56 parts, 57 parts, 58 parts, 59 parts or 60 Part.

Poria: for the dry sclerotia of On Polyporaceae Poria, sweet in the mouth, light, property is put down, for edema oliguria, phlegm retention vertigo and palpitation, Insufficiency of the spleen lack of appetite, loose stool has loose bowels, irritability, palpitation with fear insomnia.

In the present invention, the typical but non-limiting content of described Poria is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 Part, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 Part, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts, 56 parts, 57 parts, 58 parts, 59 parts or 60 Part.

Semen Coicis: the dry mature kernal of grass Semen Coicis.Semen Coicis has promoting diuresis to eliminate damp pathogen, invigorating the spleen to arrest diarrhea, eliminating impediment, row Pus and effect of detoxicating and resolving stagnation of pathogens, for edema, tinea pedis, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, acute appendicitis, cancerous protuberance and Wart.

In the present invention, the typical but non-limiting content of described Semen Coicis is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 Part, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 Part, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts, 56 parts, 57 parts, 58 parts, 59 parts or 60 Part.

Herba Ephedrae: for the dry herb stem of Ephedraceae plant plait Herba Ephedrae, epheday intermedia or ephedra equisetina, it is warm in nature, acrid in the mouth, micro- Hardship, Herba Ephedrae has effect of diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema, can be used for treating anemofrigid cold, uncomfortable in chest breath with cough, edema due to wind pathogen The disease such as edema and bronchial asthma.

In the present invention, the typical but non-limiting content of described Herba Ephedrae is: 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 Part, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 Part, 27 parts, 28 parts, 29 parts or 30 parts.

Semen Armeniacae Amarum: Semen Armeniacae Amarum master enters lung meridian, bitter in the mouth can drop, and hold concurrently and dredge the property opened of profit, have concurrently among fall lung qi lung qi dispersing merit and Reach relieving cough and asthma, for controlling the key medicine of cough with asthma.Multiple cough with asthma disease is can be used for card compatibility.

In the present invention, the typical but non-limiting content of described Semen Armeniacae Amarum is: 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 Part, 12 parts, 13 parts, 14 parts or 15 parts.

Cortex Magnoliae Officinalis: main product, in the ground such as Sichuan, Hubei, is used as medicine with dry dried bark, root bark and branch skin.Cortex Magnoliae Officinalis have circulation of qi promoting removing dampness, Warming middle-JIAO to relieve pain, effect of lowering the adverse QI to relieve asthma, for stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea, expectorant stops up QI rising in reverse order and breast Completely breath with cough.

In the present invention, the typical but non-limiting content of described Cortex Magnoliae Officinalis is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 Part, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 Part, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts, 56 parts, 57 parts, 58 parts, 59 parts or 60 Part.

Bulbus Fritillariae Uninbracteatae: for liliaceous plant Bulbus Fritillariae Cirrhosae and the dry bulb of Bulbus Fritillariae Thunbergii, be conventional preventing phlegm from forming and stopping coughing medicine, cure mainly heat-phlegm Cough, exogenous cough, cough due to yin deficiency, the few parched throat of expectorant, the yellow disease such as thick, lung abscess, acute mastitis, ulcerative carbuncle toxic swelling and scrofula of coughing up phlegm.

In the present invention, the typical but non-limiting content of described Bulbus Fritillariae Uninbracteatae is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Radix Platycodonis: herbaceos perennial, is used as medicine with root, has lung qi dispersing, sore-throat relieving, eliminates the phlegm and effect of evacuation of pus, is used for coughing Abundant expectoration, not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus uncomfortable in chest and skin infection difficulty in discharging of pus.

In the present invention, the typical but non-limiting content of described Radix Platycodonis is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Radix Asteris: for Compositae Aster herbaceos perennial, there is the effects such as warming the lung, the therapeutic method to keep the adverse QI flowing downwards, expectorant, cough-relieving, for wind Cold cough and asthma, asthenia cough vomiting bloody pus, sore throat and dysuria.

In the present invention, the typical but non-limiting content of described Radix Asteris is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Flos Farfarae: for the dry flower of feverfew coltsfoot, have effect of nourishing the lung to keep the adverse QI downward and relieving cough and resolving phlegm, is usually used in new Chronic cough is coughed, dyspnea and cough with excessive sputum and chronic cough hemoptysis.

In the present invention, the typical but non-limiting content of described Flos Farfarae is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Pericarpium Citri Reticulatae: for rutaceae orange and the dry mature skin of variety thereof, return lung, spleen channel, for distension and fullness in the abdomen, Lack of appetite and vomiting, cough with copious phlegm.

In the present invention, the typical but non-limiting content of described Pericarpium Citri Reticulatae is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

The Rhizoma Pinelliae: for Araeceae medicinal plants, there is effect of drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, for abundant expectoration The headache of cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm, vomiting regurgitation, breast gastral cavity painful abdominal mass be vexed and globus hystericus.

In the present invention, the typical but non-limiting content of the described Rhizoma Pinelliae is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Fructus Psoraleae: for the annual upright herbaceous plant of Rosa pulse family, have kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, frequent micturition, Warming spleen and stopping diarrha effect with helping inspiration to relieve asthma.Fructus Psoraleae is usually used in treating the deficiency and coldness of failure of the kidney in receiving QI and breathes with cough.

In the present invention, the typical but non-limiting content of described Fructus Psoraleae is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Fructus Lycii: for the mature fruit of matrimony vine of solanaceae plant, there is effect of nourishing the liver and kidney, replenishing vital essence to improve eyesight, for Liver and kidney The card of the deficiency of YIN.The sweet flat matter of Fructus Lycii moisten, can flat invigorating the liver and kidney, have the effect of strengthening by means of tonics, all cards of all hepatic and renal YIN deficiency all can apply.

In the present invention, the typical but non-limiting content of described Fructus Lycii is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Fructus Ligustri Lucidi: for the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi, has a liver and kidney tonifying, improving eyesight, effect of clearind deficient heat, Have a dizzy spell for treatment, early whitening of beard and hair, the disease such as blurring of vision and fever due to yin deficiency.

In the present invention, the typical but non-limiting content of described Fructus Ligustri Lucidi is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Fructus Perillae: for the dry mature fruit of labiate Folium Perillae, there is sending down the abnormal ascending QI expectorant, relieving asthma, the effect such as intestine moistening, use The diseases such as QI rising in reverse order, cough and asthma, dryness of the intestine constipation are stopped up in expectorant.

In the present invention, the typical but non-limiting content of described Fructus Perillae is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Fructus Amomi: be the conventional armaticity medical material simply of the traditional Chinese medical science, be used as medicine with mature fruit or seed.Fructus Amomi mainly acts on people The stomach of body, kidney and spleen, it is possible to circulation of qi promoting seasoning, stomach function regulating are amusing, be suitable for treating the disease such as fullness in the epigastrium and chest, abdominal distention and little diet.

In the present invention, the typical but non-limiting content of described Fructus Amomi is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Fructus Amomi Rotundus: for perennial evergreen herbaceous plant, produces the south of the Five Ridges, has removing dampness and disappears painful abdominal mass, circulation of qi promoting warming middle-JIAO, the merit of appetite-stimulating indigestion-relieving Effect, for turbid damp obstructing in middle-JIAO, anorexia, hygropyrexia from the beginning of, the most hungry, cold-damp vomiting, chest and abdomen swelling and pain, food stagnation uncomfortable in chest do not disappear.

In the present invention, the typical but non-limiting content of described Fructus Amomi Rotundus is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Cortex Cinnamomi: for the dry bark of canella Cortex Cinnamomi, there is complement positive, warming the spleen and stomach, removing accumulated cold, effect of promoting blood circulation, For decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion collapse, stomachache have loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature multiple abscess and The floating more heat in the upper and cold in the lower of empty sun.

In the present invention, the typical but non-limiting content of described Cortex Cinnamomi is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Fructus Jujubae: Fructus Jujubae sweet in the mouth is warm in nature, return taste warp, has invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, the function of the mitigation property of medicine.Pharmacology is ground Studying carefully discovery, Fructus Jujubae can promote the generation of leukocyte, reduces serum cholesterol, improves serum albumin, the liver protecting, goes back in Fructus Jujubae Containing anticancer, the cancerous cell material to normal cell turnover even can be made.

In the present invention, the typical but non-limiting content of described Fructus Jujubae is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 Part, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 Part, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts, 56 parts, 57 parts, 58 parts, 59 parts or 60 Part.

Radix Scutellariae: be Labiatae Scutellaria herbaceos perennial, has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, the merit such as antiabortive Effect, cures mainly epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis and conjunctival congestion.

In the present invention, the typical but non-limiting content of described Radix Scutellariae is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Radix Glycyrrhizae Preparata: Radix Glycyrrhizae Preparata is the Radix Glycyrrhizae baked with honey, and primary efficacy is and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription, It is usually used in weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.

In the present invention, the typical but non-limiting content of described Radix Glycyrrhizae Preparata is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Fructus Tritici Levis: for the fruit of the dry frivolous lack of filling power of grass family Triticum plant Semen Tritici aestivi, there is QI invigorating, heat extraction, hidroschesis Effect, be usually used in hectic fever due to YIN-deficiency consumptive fever, spontaneous sweating.

In the present invention, the typical but non-limiting content of described Fructus Tritici Levis is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Herba Schizonepetae: be Labiatae, Nepeta perennial plant, taste is flat, and warm in nature, nontoxic, faint scent is dense.Herba Schizonepetae is sweating and heat resolving Medicine, is one of conventional medical herbs of China, can town expectorant, dispel the wind, removing heat from blood, for influenza, headache cold and heat diaphoresis, vomiting.

In the present invention, the typical but non-limiting content of described Herba Schizonepetae is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Radix Saposhnikoviae: herbaceos perennial, its nice and cool weather of happiness, cold-resistant, drought-resistant, main product in Hebei, Heilungkiang, Sichuan, The ground such as the Inner Mongol, acrid in the mouth, sweet, slightly warm in nature.There are expelling pathogenic wind from the body surface, removing dampness to relieve pain, effect of relieving convulsion.

In the present invention, the typical but non-limiting content of described Radix Saposhnikoviae is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

The Radix Astragali: have another name called continuous stilbene, main root is plump, wooden, normal branch, and canescence originates in the Inner Mongol, Shanxi, Gansu, Heilungkiang Etc. ground, its have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and wide antibacterial action.

In the present invention, the typical but non-limiting content of the described Radix Astragali is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 Part, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 Part, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts, 56 parts, 57 parts, 58 parts, 59 parts or 60 Part.

Semen Persicae: for the dry mature seed of rosaceous plant Fructus Persicae, there is blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, the merit of relieving cough and asthma Effect, for amenorrhea dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, lung abscess acute appendicitis, injury from falling down, dryness of the intestine constipation, cough and asthma.

In the present invention, the typical but non-limiting content of described Semen Persicae is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Radix Paeoniae Rubra: for ranunculaceae plant Radix Paeoniae Rubra or the dry root of river Radix Paeoniae Rubra, have effect of clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, uses In thermal man's nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, addiction abdominal mass stomachache, injury from falling down, carbuncle Swollen skin infection.

In the present invention, the typical but non-limiting content of described Radix Paeoniae Rubra is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Herba Leonuri: acrid in the mouth is bitter, cool, have invigorate blood circulation, silt of dispelling, regulating menstruation, the effect of the water that disappears, treat menoxenia, vaginal bleeding during pregnancy Difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.

In the present invention, the typical but non-limiting content of described Herba Leonuri is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

Fructus Crataegi: have another name called in mountain fruit, Fructus Pyri Pashiae, Rosaceae Crataegus, deciduous tree, drying after can be used as medicine, be that China is peculiar Medicine fruit dual-purpose seeds, there is the effect such as blood fat reducing, blood pressure, heart tonifying, arrhythmia, be also spleen benefiting and stimulating the appetite, digestion-promoting simultaneously Stagnant, the good medicine of phlegm reduction of blood circulation promoting, the disease such as, hernia, blood stasis full to chest and diaphragm spleen, amenorrhea has good curative effect.

In the present invention, the typical but non-limiting content of described Fructus Crataegi is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 Part.

The cream side for chronic obstructive pulmonary disease that the present invention makes after carrying out compatibility by above-mentioned medical material, has lung moistening The effects such as cough-relieving, lung qi dispersing sore-throat relieving, evacuation of pus of eliminating the phlegm, lowering the adverse QI to relieve asthma and nourishing the liver and kidney are deficient, lead for chronic obstructive pulmonary disease The diseases such as the expectoration caused is breathed hard, the uncomfortable in chest and dyspnea of panting.Medical material in above-mentioned compatibility is not only able to each play original medicine Effect of thing, and can further strengthen its curative effect, the effect to treatment chronic obstructive pulmonary disease is better than existing medicine.

" including " of the present invention, it is intended that it is in addition to described crude drug, it is also possible to include other components, these other groups Divide and give the different characteristic of described medicine or mouthfeel.In addition, " including " of the present invention, it is also possible to replace with closed " be " or " by ... composition ".

Such as: the crude drug in the present invention also includes crystal sugar and/or Mel.

In such scheme preferably, described crude drug includes the medical material of following weight portion: Radix Codonopsis 20～50 parts, the Rhizoma Atractylodis Macrocephalae 20～50 parts, Rhizoma Atractylodis 20～50 parts, Poria 20～50 parts, Semen Coicis 20～50 parts, Herba Ephedrae 10～20 parts, Semen Armeniacae Amarum 10～15 parts, Cortex Magnoliae Officinalis 20～50 parts, Bulbus Fritillariae Uninbracteatae 15～20 parts, Radix Platycodonis 15～20 parts, Radix Asteris 15～20 parts, Flos Farfarae 15～20 parts, Pericarpium Citri Reticulatae 15～20 Part, the Rhizoma Pinelliae 15～20 parts, Fructus Psoraleae 15～20 parts, Fructus Lycii 15～20 parts, Fructus Ligustri Lucidi 15～20 parts, Fructus Perillae 15～20 parts, Fructus Amomi 15～20 parts, Fructus Amomi Rotundus 15～20 parts, Cortex Cinnamomi 15～20 parts, Fructus Jujubae 20～50 parts, Radix Scutellariae 15～20 parts, Radix Glycyrrhizae Preparata 15～20 Part, Fructus Tritici Levis 15～20 parts, Herba Schizonepetae 15～20 parts, Radix Saposhnikoviae 15～20 parts, the Radix Astragali 20～50 parts, Semen Persicae 15～20 parts, Radix Paeoniae Rubra 15 ～20 parts, Herba Leonuri 15～20 parts and Fructus Crataegi 15～20 parts.

Preferably, described crude drug includes the medical material of following weight portion to any of the above-described scheme: Radix Codonopsis 50 parts, the Rhizoma Atractylodis Macrocephalae 50 Part, Rhizoma Atractylodis 50 parts, 50 parts of Poria, Semen Coicis 50 parts, 20 parts of Herba Ephedrae, 15 parts of Semen Armeniacae Amarum, Cortex Magnoliae Officinalis 50 parts, Bulbus Fritillariae Uninbracteatae 20 parts, Radix Platycodonis 20 parts, Radix Asteris 20 parts, Flos Farfarae 20 parts, Pericarpium Citri Reticulatae 20 parts, the Rhizoma Pinelliae 20 parts, Fructus Psoraleae 20 parts, Fructus Lycii 20 parts, Fructus Ligustri Lucidi 20 parts, Fructus Perillae 20 parts, Fructus Amomi 20 parts, 20 parts of Fructus Amomi Rotundus, Cortex Cinnamomi 20 parts, 50 parts of Fructus Jujubae, Radix Scutellariae 20 parts, Radix Glycyrrhizae Preparata 20 parts, Fructus Tritici Levis 20 parts, Herba Schizonepetae 20 parts, Radix Saposhnikoviae 20 parts, the Radix Astragali 20 parts, 20 parts of Semen Persicae, Radix Paeoniae Rubra 20 parts, Herba Leonuri 20 parts and Fructus Crataegi 20 parts.

Further, described Colla Corii Asini is calculated as 10～60 weight portions by weight.

Colla Corii Asini: for the skin of equine species donkey, the solid gum through decocting, concentration is made.The nourishing that Colla Corii Asini is traditional is top grade, for Enrich blood panacea.Colla Corii Asini has YIN nourishing of enriching blood, moisturizes effect of hemostasis, for blood deficiency and yellow complexion, dizziness cardiopalmus, dysphoria and insomnia and lung Cough caused by dryness such as is coughed the disease.

In the present invention, the typical but non-limiting content of described Colla Corii Asini is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 Part, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 Part, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts, 56 parts, 57 parts, 58 parts, 59 parts or 60 Part.

In the present invention, Colla Corii Asini is mixed the crude drug medicinal liquid after dense decocting, uses Colla Corii Asini to foreignize into the feature of cream by raw material A kind of semi-fluid unguentum of stiff shape that medicine medicinal liquid is made.Not only make the cream side made possess original nourishing the lung to arrest cough, lung qi dispersing sore-throat relieving, Eliminate the phlegm the effects such as evacuation of pus, lowering the adverse QI to relieve asthma and nourishing the liver and kidney be deficient, also enhance cream side simultaneously and enrich blood YIN nourishing, the effect moisturized.

Further, described crude drug also includes crystal sugar 10～20 weight portion and/or Mel 10～20 weight portion.

Crystal sugar: there is invigorating the spleen and replenishing QI, stomach function regulating lung moistening, can cough with cough-relieving, reduce phlegm saliva and relax the property of medicine.

In the present invention, the typical but non-limiting content of described Mel is: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts or 20 parts.

Mel: have invigorating middle warmer, moisturize, pain relieving, effect of removing toxic substances, for gastral cavity abdomen void pain, dryness of the lung dry cough, dryness of the intestine constipation and Relax the property of medicine.

In the present invention, add crystal sugar and Mel not only can also neutralize all crude drug in compound recipe medical material with flavor adjustment The property of medicine.

The preparation method of the present invention have employed following preparation scheme: includes following preparation process:

Step (1) soaks medical material: by aforesaid arbitrary weight portion weighting raw materials, the raw material then weighed by cold water soak Medicine, soak time 12～24 hours；

Further, soak medical material and preferably use earth pot or ceramic pan to soak, avoid and soak medical material with iron pan and metallic article, In order to avoid affecting quality and the mouthfeel of later stage cream side.

Further, after adding cold water, typically exceeding crude drug 15 centimetres with water surface elevation and be advisable, the water surface must be higher than Medical material, but the most should be not too high, in order to avoid impact decocts the efficiency extracted.

Step (2) decoction filtering: the crude drug after immersion treatment is heated, fire of larding speech with literary allusions after being heated to medicinal liquid boiling, Decoct 1～2 hour, filter out medicine juice subsequently, add cold water soak medicinal liquid；Repeat above-mentioned decoction filtering step 3～4 times, will Medicinal liquid after decocting for each time all merges；

Further, crude drug should stir when decocting in time, prevents medical material to be burned, and removes the foam floating on surface, decocts Liquid medicine spill to be avoided during boiling.

Step (3) concentrates receives cream: the medicinal liquid slow fire after merging in step (2) keeps micro-boiling to concentrate, and works as medicinal liquid When being condensed into the thick shape of cream, add Colla Corii Asini, be stirred continuously simultaneously, when medicinal liquid becomes paste, receive cream and complete；

Further, during concentrating receipts cream, when entering Colla Corii Asini down, to be stirred continuously simultaneously, prevent Colla Corii Asini Coking sticky end, in order to avoid affecting quality and the mouthfeel of finished product.

Further, the cream side prepared can put into preservation in container, and preservation container is advisable with porcelain jar, glass jar, no Available metalware is deposited, in order to avoid causing chemical reaction.

Further, because in cream side, sugar content is higher, temperature is too high apt to deteriorate mouldy, so should put into ice after making Case, 4 DEG C of stored refrigerated, otherwise can go bad and affect drug effect.

Further, the soak time in described step (1) is 12 hours.

In the present invention, depending on the soak time of medical material should be according to the property of medicine, the crude drug great majority used in this cream side are one The Chinese herbal medicine of a little light weights, soak time is unsuitable long in order to avoid losing drug effect, should be advisable with 12 hours.Medical material for some matter weight Such as Radix Codonopsis etc., it is possible to extend soak time.

Further, after the medicinal liquid after decocting for each time in described step (2) merges, 20～30 minutes are stood subsequently, with disappearing Poison filtered through gauze, to remove the impurity in medicinal liquid.

In the present invention, after the medicinal liquid after decocting each time merges, stand 20～30 minutes, can be abundant by the impurity in medicinal liquid Precipitation, can filter several times with antiseptic gauze, to remove the impurity in medicinal liquid subsequently.

Further, the powder after 100～120 mesh sieves is crossed after the Colla Corii Asini of addition is pulverizing in described step (3).

In the present invention, by the Colla Corii Asini powder that Colla Corii Asini pulverizing was 100～120 mesh sieves, can in the preparation process receiving cream more Uniform addition Colla Corii Asini powder.

Further, after described step (3) adds Colla Corii Asini, crystal sugar can be added and/or Mel stirs, when medicinal liquid becomes During paste, receive cream and complete.

Owing to crystal sugar and Mel should not soak decoction in advance, so it can not be prepared together with other drug, need Add during receiving cream.

Further, the present invention provide the cream side for chronic obstructive pulmonary disease effectively can alleviate chronic obstruction Property the expectoration that causes of lung disease breathe hard, the symptom such as the uncomfortable in chest and dyspnea of panting, improve the immunity of patient simultaneously, reduce disease The recurrence of feelings with increase the weight of, thus delay and stop the development of the state of an illness, improve the life quality of patient.

Compared with prior art, the invention have the benefit that

(1) what the present invention used is unique for the cream side of chronic obstructive pulmonary disease prescription, evident in efficacy, through this prescription Unique compatibility, each medicine in crude drug is not only able to play effect of original medicine, simultaneously its curative effect energy after combination Further strengthen, can effectively alleviate the expectoration that chronic obstructive pulmonary disease causes breathe hard, uncomfortable in chest and dyspnea of panting Etc. symptom, improve the immunity of patient simultaneously, reduce the recurrence of the state of an illness and increase the weight of, thus delay and stop the development of the state of an illness, carry The life quality of high patient.

(2) present invention is oral pastes, relative to the Chinese medicine for the treatment of chronic obstructive pulmonary disease more of the prior art Decoction, this unguentum concentrating degree is high, dose is little, medication is convenient and patient good in taste is prone to accept.

(3) the preparation method technique of the cream side of the chronic obstructive pulmonary disease that the present invention uses is simple, flow process safety, whole Preparation process need not special Preparation equipment.Meanwhile, the chronic obstructive pulmonary disease prepared by this preparation method Cream side, concentrating degree is high, and mouthfeel is also preferable, at utmost remains the medicinal efficacy of each medical material.

The curative effect of medication of the present invention be exemplified below:

Case 1, Wang, female 65 years old, people from Urumqi City, cough and expectoration more than 10 years of asthma, diagnosing chronic obstructive pulmonary disease Sick 5 years, annual outbreak 2-3 time, every time outbreak 2-3 week, venous transfusion antibiotic and antiasthmatic-antitussive medicine need to be used can to alleviate, surely Periodically showing as, cough, expectoration, asthma, limitation of activity, dietary amount reduces, loses weight, and institute goes to a doctor in me in February, 2014, Prescription takes with chronic obstructive pulmonary disease cream square opening, every day twice, and after January of taking medicine, patient's cough, expectoration symptom alleviate, movable Rear asthma has alleviation, has expectorant easily to bring up, and sweating reduces, and dietary amount has increase, and abdominal distention sense after meal alleviates, CAT scoring after March of taking medicine By medication first 24 points near 12 points, within 6 minutes, walking distance is increased to 512 meters by first 358 meters of medication, and acute exacerbation thing occurs the most again Part.

Case 2, Zhang, man 61 years old, people from Urumqi City, more than 30 years of smoking, cough, expectoration, asthma recurrent exerbation more than 10 Year, showing effect 3-4 time every year over nearly 3 years, weekday daytime cough is more, and expectoration amount is many, and asthma uncomfortable in chest is obvious, and next level need to be stopped Breath, sweating is more on ordinary days, and aversion to wind is afraid of cold, in February, 2014 in my institute's hospitalization, band chronic obstructive pulmonary disease cream when leaving hospital Side takes, and after January of taking medicine, self-induction expectoration amount is reduced, and sense uncomfortable in chest alleviates, and sweating alleviates, and weak sense alleviates, self-induction after March of taking medicine Sweating reduces, and limbs fatigue sense substantially alleviates, and acute exacerbation do not occurs, and mobility increases, 6 minutes walk test distances by with First 280 meters of medicine, increases to 412 meters.

Case 3, Liu, man 78 years old, people from Urumqi City, in more than 30 years of smoking, suffers from more than 10 years of chronic bronchitis, before 2 years It is diagnosed as chronic obstructive pulmonary disease, cough, expectoration, asthma recurrent exerbation, whenever seasonal variations, easily shows effect after flu, on ordinary days In self-induction dizziness weak, distension and fullness in the abdomen, dietary amount reduces, and sweating is obvious, occasionally has asthma uncomfortable in chest, and itching throat is coughed, and has expectorant to be difficult to cough up Go out.In April, 2014 because of acute exacerbations in patients with chronic obstructive pulmonary disease hospitalization, sentences Chronic obstructive pulmonary disease in my institute when leaving hospital Sick cream side takes, every day twice, and after patient medication January, the weak sense of self-induction alleviates, and sweating reduces, and expectorant easily brings up, and sense uncomfortable in chest alleviates, Abdominal distention sense alleviates.Self-induction malaise sense after March of taking medicine alleviates, and sweating is inconspicuous, and nighttime sleep has improvement, dietary amount to have increasing Adding, abdominal distention sense is inconspicuous, and exercise tolerance has increase earlier above, and CAT marks by 28 points near 9 points.Effect is obvious.

Case 4, Wang, female 65 years old, people from Diggings of Miquan City, cough, expectoration asthma more than 20 years of recurrent exerbation, layer Multiple Hospitalization, still Having asthma uncomfortable in chest to increase the weight of year by year, self-inductor void is weak on ordinary days, sweating, and without appetite, dietary amount reduces substantially, and abdominal distention is obvious after meal, Asthma uncomfortable in chest, night is obvious, impact sleep, often accompanies whistling sound in the throat, and conscious have expectorant to be difficult to expectoration.In December, 2015 is in my institute Hospitalization, sentences chronic obstructive pulmonary disease cream side and takes when leaving hospital, patient's expectorant in self-induction pharynx of taking medicine after January easily brings up, and coughs Having coughed and alleviated, sense uncomfortable in chest alleviates, and diet has appetite, and after March of taking medicine, self-induction sweating alleviates, and weak sense alleviates, and abdominal distention sense after meal is bright Aobvious alleviating, breathe heavily night and suppress symptom and alleviate, nighttime sleep improves, and CAT marks by 18 points near 6 points, and within 6 minutes, walking distance is by 410 Rice increases to 485 meters.

Case 5, Liu, man 55 years old, inhabitation Changji City, do not give up smoking in more than 30 years of smoking, occur over nearly 10 years cough, expectoration, Asthma, recurrent exerbation uncomfortable in chest, be once diagnosed as chronic bronchitis in local hospital, take a favorable turn through treatment but still has recurrent exerbation, Breathe heavily to suppress and increase the weight of, be diagnosed as chronic obstructive pulmonary disease in December, 2015 in my institute's hospitalization, take a turn for the better after treatment and leave hospital, go out Giving COPD cream square opening clothes during institute, following the service chronic obstructive pulmonary disease cream side twice on the one after patient discharge, after January, self-induction is coughed Coughing, expectoration has alleviation, suffocated breathing symptom uncomfortable in chest to take a favorable turn, and coughs after March of taking medicine, and expectoration is clearly better, and suffocated breathing uncomfortable in chest improves, remaining disease Shape: abdominal distention, indigestion and loss of appetite, limbs fatigue, soreness of the waist and knees, loose stool, the symptom such as aversion to wind spontaneous perspiration all gets better and turns, and CAT marks, before medication 20 points, after medication March near 12 points, gait test in 6 minutes first 320 meters of medication of distance, after medication March 450 meters.

Detailed description of the invention

Below in conjunction with embodiment, embodiment of the present invention are described in detail, but those skilled in the art will Understanding, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.In embodiment unreceipted specifically Condition person, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or instrument unreceipted production firm person, be Can be by the commercially available conventional products bought and obtain.

Embodiment 1

A kind of cream side for chronic obstructive pulmonary disease, including Colla Corii Asini and crude drug, wherein, described crude drug includes The medical material of following weight portion: Radix Codonopsis 60 parts, the Rhizoma Atractylodis Macrocephalae 60 parts, Rhizoma Atractylodis 60 parts, 60 parts of Poria, Semen Coicis 60 parts, 30 parts of Herba Ephedrae, Semen Armeniacae Amarum 15 parts, Cortex Magnoliae Officinalis 60 parts, Bulbus Fritillariae Uninbracteatae 30 parts, Radix Platycodonis 30 parts, Radix Asteris 30 parts, Flos Farfarae 30 parts, Pericarpium Citri Reticulatae 30 parts, the Rhizoma Pinelliae 30 parts, Fructus Psoraleae 30 parts, Fructus Lycii 30 parts, Fructus Ligustri Lucidi 30 parts, Fructus Perillae 30 parts, Fructus Amomi 30 parts, 30 parts of Fructus Amomi Rotundus, Cortex Cinnamomi 30 parts, 60 parts of Fructus Jujubae, yellow A kind of reed mentioned in ancient books 30 parts, Radix Glycyrrhizae Preparata 30 parts, Fructus Tritici Levis 30 parts, Herba Schizonepetae 30 parts, Radix Saposhnikoviae 30 parts, the Radix Astragali 60 parts, 30 parts of Semen Persicae, Radix Paeoniae Rubra 30 parts, benefit Herba Linderniae Crustaceae 30 parts and Fructus Crataegi 30 parts.

The content of above-mentioned Colla Corii Asini is 60 weight portions.

Embodiment 2

A kind of cream side for chronic obstructive pulmonary disease, including Colla Corii Asini and crude drug, wherein, described crude drug includes The medical material of following weight portion: Radix Codonopsis 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Rhizoma Atractylodis 10 parts, 10 parts of Poria, Semen Coicis 10 parts, 5 parts of Herba Ephedrae, Semen Armeniacae Amarum 5 Part, Cortex Magnoliae Officinalis 10 parts, Bulbus Fritillariae Uninbracteatae 10 parts, Radix Platycodonis 14 parts, Radix Asteris 10 parts, Flos Farfarae 15 parts, Pericarpium Citri Reticulatae 14 parts, the Rhizoma Pinelliae 10 parts, Fructus Psoraleae 10 Part, Fructus Lycii 10 parts, Fructus Ligustri Lucidi 10 parts, Fructus Perillae 10 parts, Fructus Amomi 20 parts, 10 parts of Fructus Amomi Rotundus, Cortex Cinnamomi 10 parts, 10 parts of Fructus Jujubae, Radix Scutellariae 10 parts, Radix Glycyrrhizae Preparata 20 parts, Fructus Tritici Levis 22 parts, Herba Schizonepetae 18 parts, Radix Saposhnikoviae 16 parts, the Radix Astragali 15 parts, 14 parts of Semen Persicae, Radix Paeoniae Rubra 15 parts, Herba Leonuri Grass 10 parts and Fructus Crataegi 10 parts.

The content of above-mentioned Colla Corii Asini is 10 weight portions.

Embodiment 3

A kind of cream side for chronic obstructive pulmonary disease, including Colla Corii Asini and crude drug, wherein, described crude drug includes The medical material of following weight portion: Radix Codonopsis 50 parts, the Rhizoma Atractylodis Macrocephalae 50 parts, Rhizoma Atractylodis 50 parts, 50 parts of Poria, Semen Coicis 50 parts, 20 parts of Herba Ephedrae, Semen Armeniacae Amarum 15 parts, Cortex Magnoliae Officinalis 50 parts, Bulbus Fritillariae Uninbracteatae 20 parts, Radix Platycodonis 20 parts, Radix Asteris 20 parts, Flos Farfarae 20 parts, Pericarpium Citri Reticulatae 20 parts, the Rhizoma Pinelliae 20 parts, Fructus Psoraleae 20 parts, Fructus Lycii 20 parts, Fructus Ligustri Lucidi 20 parts, Fructus Perillae 20 parts, Fructus Amomi 20 parts, 20 parts of Fructus Amomi Rotundus, Cortex Cinnamomi 20 parts, 50 parts of Fructus Jujubae, yellow A kind of reed mentioned in ancient books 20 parts, Radix Glycyrrhizae Preparata 20 parts, Fructus Tritici Levis 20 parts, Herba Schizonepetae 20 parts, Radix Saposhnikoviae 20 parts, the Radix Astragali 20 parts, 20 parts of Semen Persicae, Radix Paeoniae Rubra 20 parts, benefit Herba Linderniae Crustaceae 20 parts and Fructus Crataegi 20 parts.

The content of above-mentioned Colla Corii Asini is 60 weight portions.

Embodiment 4

A kind of cream side for chronic obstructive pulmonary disease, including Colla Corii Asini and crude drug, wherein, described crude drug includes The medical material of following weight portion: Radix Codonopsis 26 parts, the Rhizoma Atractylodis Macrocephalae 27 parts, Rhizoma Atractylodis 24 parts, 25 parts of Poria, Semen Coicis 25 parts, 24 parts of Herba Ephedrae, Semen Armeniacae Amarum 13 parts, Cortex Magnoliae Officinalis 27 parts, Bulbus Fritillariae Uninbracteatae 13 parts, Radix Platycodonis 27 parts, Radix Asteris 23 parts, Flos Farfarae 22 parts, Pericarpium Citri Reticulatae 22 parts, the Rhizoma Pinelliae 28 parts, Fructus Psoraleae 19 parts, Fructus Lycii 22 parts, Fructus Ligustri Lucidi 24 parts, Fructus Perillae 23 parts, Fructus Amomi 26 parts, 23 parts of Fructus Amomi Rotundus, Cortex Cinnamomi 26 parts, 32 parts of Fructus Jujubae, yellow A kind of reed mentioned in ancient books 23 parts, Radix Glycyrrhizae Preparata 26 parts, Fructus Tritici Levis 23 parts, Herba Schizonepetae 22 parts, Radix Saposhnikoviae 27 parts, the Radix Astragali 20 parts, 20 parts of Semen Persicae, Radix Paeoniae Rubra 29 parts, benefit Herba Linderniae Crustaceae 28 parts and Fructus Crataegi 25 parts.

The content of above-mentioned Colla Corii Asini is 35 weight portions.

Embodiment 5

A kind of cream side for chronic obstructive pulmonary disease, including Colla Corii Asini and crude drug, wherein, described crude drug includes The medical material of following weight portion: Radix Codonopsis 17 parts, the Rhizoma Atractylodis Macrocephalae 17 parts, Rhizoma Atractylodis 14 parts, 19 parts of Poria, Semen Coicis 18 parts, 7 parts of Herba Ephedrae, Semen Armeniacae Amarum 9 Part, Cortex Magnoliae Officinalis 18 parts, Bulbus Fritillariae Uninbracteatae 18 parts, Radix Platycodonis 14 parts, Radix Asteris 19 parts, Flos Farfarae 19 parts, Pericarpium Citri Reticulatae 14 parts, the Rhizoma Pinelliae 19 parts, Fructus Psoraleae 10 Part, Fructus Lycii 33 parts, Fructus Ligustri Lucidi 19 parts, Fructus Perillae 15 parts, Fructus Amomi 29 parts, 18 parts of Fructus Amomi Rotundus, Cortex Cinnamomi 16 parts, 10 parts of Fructus Jujubae, Radix Scutellariae 34 parts, Radix Glycyrrhizae Preparata 26 parts, Fructus Tritici Levis 22 parts, Herba Schizonepetae 18 parts, Radix Saposhnikoviae 16 parts, the Radix Astragali 15 parts, 14 parts of Semen Persicae, Radix Paeoniae Rubra 15 parts, Herba Leonuri Grass 10 parts and Fructus Crataegi 24 parts.

The content of above-mentioned Colla Corii Asini is 40 weight portions.

Embodiment 6

The preparation method of the cream side of above-mentioned chronic obstructive pulmonary disease, including following preparation process:

Step (1) soaks medical material: by the weight portion weighting raw materials described in above-described embodiment 1, then use cold water soak The crude drug weighed, after adding cold water, typically exceeds crude drug 12 centimetres with water surface elevation and is advisable, soak 16 hours；

Step (2) decoction filtering: the crude drug after immersion treatment is heated, fire of larding speech with literary allusions after being heated to medicinal liquid boiling, Decocting 1 hour, crude drug should stir when decocting in time, prevents medical material to be burned, and removes the foam floating on surface, in decoction process Liquid medicine spill to be avoided.Filter out medicine juice subsequently, add cold water soak medicinal liquid；Repeat above-mentioned decoction filtering step 3 time, will be each Medicinal liquid after secondary decoction all merges；Medicinal liquid after merging subsequently stands 24 minutes, filters with antiseptic gauze, to remove medicinal liquid In impurity.

Step (3) concentrates receives cream: the medicinal liquid slow fire after merging in step (2) keeps micro-boiling to concentrate, and works as medicinal liquid When forming thick shape, add Colla Corii Asini, be stirred continuously simultaneously, prevent Colla Corii Asini coking sticky end, when medicinal liquid becomes paste, receive cream and complete；

Step (4) deposits cream preservation: the cream side after receiving cream in step (3) puts in glass jar, 4 DEG C of stored refrigerated subsequently, It is on the waiting list.

Embodiment 7

Step (1) soaks medical material: by the weight portion weighting raw materials described in above-described embodiment 2, then use cold water soak The crude drug weighed, after adding cold water, typically exceeds crude drug 15 centimetres with water surface elevation and is advisable, soak 18 hours；

Step (2) decoction filtering: the crude drug after immersion treatment is heated, fire of larding speech with literary allusions after being heated to medicinal liquid boiling, Decocting 1 hour, crude drug should stir when decocting in time, prevents medical material to be burned, and removes the foam floating on surface, in decoction process Liquid medicine spill to be avoided.Filter out medicine juice subsequently, add cold water soak medicinal liquid；Repeat above-mentioned decoction filtering step 4 time, will be each Medicinal liquid after secondary decoction all merges；Medicinal liquid after merging subsequently stands 19 minutes, filters with antiseptic gauze, to remove medicinal liquid In impurity.

Embodiment 8

Step (1) soaks medical material: by the weight portion weighting raw materials described in above-described embodiment 3, then use cold water soak The crude drug weighed, after adding cold water, typically exceeds crude drug 15 centimetres with water surface elevation and is advisable, soak 24 hours；

Step (2) decoction filtering: the crude drug after immersion treatment is heated, fire of larding speech with literary allusions after being heated to medicinal liquid boiling, Decocting 1 hour, crude drug should stir when decocting in time, prevents medical material to be burned, and removes the foam floating on surface, in decoction process Liquid medicine spill to be avoided.Filter out medicine juice subsequently, add cold water soak medicinal liquid；Repeat above-mentioned decoction filtering step 3 time, will be each Medicinal liquid after secondary decoction all merges；Medicinal liquid after merging subsequently stands 20 minutes, filters with antiseptic gauze, to remove medicinal liquid In impurity.

Effect example 1

For showing the cream side of the present invention therapeutical effect to chronic obstructive pulmonary disease, select 100 example Chronic obstructive pulmonary diseases Sick patient observes, and selects the trouble of the chronic obstructive pulmonary disease that medical history, the state of an illness, age and former Therapeutic Method are suitable simultaneously Person 100 example is as a control group.The cream side of the chronic obstructive pulmonary disease that the test group employing embodiment of the present invention 8 is made controls Treating, matched group is treated according to a conventional method, and clinical test results is as shown in table 1 below:

Therapeutic Method: the chronic obstructive pulmonary disease cream side using embodiment 5 to make takes orally, each 2g, three times a day.

Function with cure mainly: there is nourishing the lung to arrest cough, lung qi dispersing sore-throat relieving, evacuation of pus of eliminating the phlegm, lowering the adverse QI to relieve asthma and nourishing the liver and kidney deficient etc. Effect, the expectoration caused for chronic obstructive pulmonary disease breathes hard, it is uncomfortable in chest to pant and the disease such as dyspnea.

Table 1 clinical test results

After using this chronic obstructive pulmonary disease cream side 6 days, patient's expectoration of 96% is breathed hard, is panted uncomfortable in chest and breathe tired The diseases such as difficulty have the sign that substantially disappears；After 9 days, patient's expectoration of 95% is breathed hard, uncomfortable in chest substantially eliminating of panting, dyspnea and slow The diseases such as property cough have and substantially alleviate.；After using 12 days, patient's expectoration of 94% breathes hard, it is uncomfortable in chest to pant and the disease such as dyspnea Substantially eliminating, chronic cough has and substantially alleviates.Remaining patient recovers, it is contemplated that after 3～5 days, symptom all has and substantially subtracts Gently.And using the matched group of traditional therapy the most inconspicuous to every glucose recovery when 12 days, effect is the most notable.

Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that without departing substantially from the present invention's May be made that in the case of spirit and scope many other change and amendment.It is, therefore, intended that in the following claims Including all such changes and modifications belonged in the scope of the invention.

Claims

1. the cream side for chronic obstructive pulmonary disease, including Colla Corii Asini and crude drug, it is characterised in that described crude drug Medical material including following weight portion: Radix Codonopsis 10～60 parts, the Rhizoma Atractylodis Macrocephalae 10～60 parts, Rhizoma Atractylodis 10～60 parts, Poria 10～60 parts, Semen Coicis Core 10～60 parts, Herba Ephedrae 5～30 parts, Semen Armeniacae Amarum 5～15 parts, Cortex Magnoliae Officinalis 10～60 parts, Bulbus Fritillariae Uninbracteatae 10～30 parts, Radix Platycodonis 10～30 parts, purple Aster 10～30 parts, Flos Farfarae 10～30 parts, Pericarpium Citri Reticulatae 10～30 parts, the Rhizoma Pinelliae 10～30 parts, Fructus Psoraleae 10～30 parts, Fructus Lycii 10～ 30 parts, Fructus Ligustri Lucidi 10～30 parts, Fructus Perillae 10～30 parts, Fructus Amomi 10～30 parts, Fructus Amomi Rotundus 10～30 parts, Cortex Cinnamomi 10～30 parts, big Fructus Jujubae 10～60 parts, Radix Scutellariae 10～30 parts, Radix Glycyrrhizae Preparata 10～30 parts, Fructus Tritici Levis 10～30 parts, Herba Schizonepetae 10～30 parts, Radix Saposhnikoviae 10～30 Part, the Radix Astragali 10～60 parts, Semen Persicae 10～30 parts, Radix Paeoniae Rubra 10～30 parts, Herba Leonuri 10～30 parts and Fructus Crataegi 10～30 parts.

2. the cream side for chronic obstructive pulmonary disease as claimed in claim 1, it is characterised in that described crude drug includes The medical material of following weight portion: Radix Codonopsis 20～50 parts, the Rhizoma Atractylodis Macrocephalae 20～50 parts, Rhizoma Atractylodis 20～50 parts, Poria 20～50 parts, Semen Coicis 20 ～50 parts, Herba Ephedrae 10～20 parts, Semen Armeniacae Amarum 10～15 parts, Cortex Magnoliae Officinalis 20～50 parts, Bulbus Fritillariae Uninbracteatae 15～20 parts, Radix Platycodonis 15～20 parts, Radix Asteris 15～20 parts, Flos Farfarae 15～20 parts, Pericarpium Citri Reticulatae 15～20 parts, the Rhizoma Pinelliae 15～20 parts, Fructus Psoraleae 15～20 parts, Fructus Lycii 15～20 Part, Fructus Ligustri Lucidi 15～20 parts, Fructus Perillae 15～20 parts, Fructus Amomi 15～20 parts, Fructus Amomi Rotundus 15～20 parts, Cortex Cinnamomi 15～20 parts, Fructus Jujubae 20～50 parts, Radix Scutellariae 15～20 parts, Radix Glycyrrhizae Preparata 15～20 parts, Fructus Tritici Levis 15～20 parts, Herba Schizonepetae 15～20 parts, Radix Saposhnikoviae 15～20 Part, the Radix Astragali 20～50 parts, Semen Persicae 15～20 parts, Radix Paeoniae Rubra 15～20 parts, Herba Leonuri 15～20 parts and Fructus Crataegi 15～20 parts.

3. the cream side for chronic obstructive pulmonary disease as claimed in claim 1, it is characterised in that described crude drug includes The medical material of following weight portion: Radix Codonopsis 50 parts, the Rhizoma Atractylodis Macrocephalae 50 parts, Rhizoma Atractylodis 50 parts, 50 parts of Poria, Semen Coicis 50 parts, 20 parts of Herba Ephedrae, Semen Armeniacae Amarum 15 parts, Cortex Magnoliae Officinalis 50 parts, Bulbus Fritillariae Uninbracteatae 20 parts, Radix Platycodonis 20 parts, Radix Asteris 20 parts, Flos Farfarae 20 parts, Pericarpium Citri Reticulatae 20 parts, the Rhizoma Pinelliae 20 parts, Fructus Psoraleae 20 parts, Fructus Lycii 20 parts, Fructus Ligustri Lucidi 20 parts, Fructus Perillae 20 parts, Fructus Amomi 20 parts, 20 parts of Fructus Amomi Rotundus, Cortex Cinnamomi 20 parts, 50 parts of Fructus Jujubae, yellow A kind of reed mentioned in ancient books 20 parts, Radix Glycyrrhizae Preparata 20 parts, Fructus Tritici Levis 20 parts, Herba Schizonepetae 20 parts, Radix Saposhnikoviae 20 parts, the Radix Astragali 20 parts, 20 parts of Semen Persicae, Radix Paeoniae Rubra 20 parts, benefit Herba Linderniae Crustaceae 20 parts and Fructus Crataegi 20 parts.

4. the cream side for chronic obstructive pulmonary disease as according to any one of claims 1 to 3, it is characterised in that described Colla Corii Asini is calculated as 10～60 weight portions by weight.

5. the cream side for chronic obstructive pulmonary disease as according to any one of claims 1 to 3, it is characterised in that described Crude drug also includes crystal sugar 10～20 weight portion and/or Mel 10～20 weight portion.

6. a preparation method for the cream side for chronic obstructive pulmonary disease as described in any one of Claims 1 to 5, it is special Levy and be, including following preparation process:

(1) soak medical material: the weight portion weighting raw materials as described in any one of Claims 1 to 5, then weigh by cold water soak Crude drug, soak time is 12～24 hours；

(2) decoction filtering: the crude drug after immersion treatment is heated, fire of larding speech with literary allusions after being heated to medicinal liquid boiling, decoct 1～2 Hour, filter out medicine juice subsequently, add cold water soak medicinal liquid；Repeat above-mentioned decoction filtering step 3～4 times, each time is decocted After medicinal liquid all merge；

(3) receipts cream is concentrated: the medicinal liquid slow fire after merging in step (2) concentrates, and when concentration of liquid medicine becomes the thick shape of cream, adds Enter Colla Corii Asini, be stirred continuously simultaneously, when medicinal liquid becomes paste, receive cream and complete.

7. preparation method as claimed in claim 6, it is characterised in that the soak time in described step (1) is 12 hours.

8. preparation method as claimed in claim 6, it is characterised in that described method still further comprises each in step (2) After medicinal liquid after secondary decoction merges, stand 20～30 minutes, filter, to remove the impurity in medicinal liquid with antiseptic gauze subsequently.

9. preparation method as described in claim 6, it is characterised in that after adding Colla Corii Asini in described step (3), add crystal sugar And/or Mel stirs, when medicinal liquid becomes paste, receive cream and complete.

10. as described in any one of Claims 1 to 5 for the cream side of chronic obstructive pulmonary disease preparation treatment chronic obstruction Application in the medicine of property lung disease.