CN105727069A

CN105727069A - Medicinal composition for treating chronic cholecystitis and preparation method for medicinal composition

Info

Publication number: CN105727069A
Application number: CN201610124428.6A
Authority: CN
Inventors: 李媛; 马晓莹; 高玉强
Original assignee: Qingdao Municipal Hospital
Current assignee: Qingdao Municipal Hospital
Priority date: 2016-03-04
Filing date: 2016-03-04
Publication date: 2016-07-06

Abstract

The invention discloses a medicinal composition for treating chronic cholecystitis. The medicinal composition is prepared from the following raw medicaments: longhairy antenoron herb, officinal magnolia barks, fried gardenia, Szechwan chinaberry fruits, long peppers, roses, endothelium corneum gigeriae galli, bamboo shavings, gentianopsis barbata, oysters, lythrum salicaria, mucuna sempervirens, sanguisorba officinalis, clethra loosestrife herb, pumpkin roots, coix seeds, Philippine violet herb, murraya paniculata, wolfberries, semen cassiae, cowherb seeds, acorus gramineus, rubia cordifolia, cassia twigs, green tangerine peel, hawthorns, licorice, dandelions, hedyotis diffusa, plantain seeds, willow branches, radix polygonum multiflorum preparata and northern divaricate saposhnikovia roots. According to the medicinal composition, the raw medicaments are combined on the basis of the principle of monarch, minister, assistant and guide of traditional Chinese medicine to achieve the effects of clearing liver-gallbladder, soothing the liver, promoting qi circulation, regulating qi activity, clearing away heat and toxic materials, nourishing the heart to tranquilize the mind, invigorating spleen, supplementing qi and promoting bile flow, fulfill the aim of treating chronic cholecystitis and overcome the defects of long treatment course, poor effects and high recurrence rate of modern medicine in treatment of chronic cholecystitis.

Description

A kind of pharmaceutical composition treating chronic cholecystitis and preparation method thereof

Technical field

The invention belongs to pharmaceutical technology field, relate to a kind of Chinese medicine composition, be specifically related to a kind of pharmaceutical composition treating chronic cholecystitis and preparation method thereof.

Background technology

The gallbladder inflammatory lesion that cholecystitis is bacterial infection or chemical irritation (bile component change) causes, for the commonly encountered diseases of gallbladder.In abdominal surgery, its sickness rate is only second to appendicitis, and primary disease is more common in the middle age of 35～55 years old, and the women relatively male that falls ill for many, is more common in the women of obesity and multiple pregnancies especially.

Cholecystitis is divided into chronic cholecystitis and acute cholecystitis two kinds, the normally behaving as variant position pain usually can be made to increase the weight of of acute cholecystitis, and patient likes reposing to the right more, to alleviate abdomen pain, has nausea and vomiting, but vomiting is general inviolent.Great majority are also with heating, and body temperature is generally between 38.0 DEG C～38.5 DEG C, and Gao Re and shiver with cold are actually rare.Minority also has the white of the eye and skin slightly to turn to be yellow.When checking abdominal part, it is possible to find that right upper quadrant of the abdomen has tenderness, and have tension of abdominal muscle, be approximately in the gallbladder that can also touch enlargement in the patient of 1/3.The blood of chemical examination patient, it is found that numeration of leukocyte in most human bloods and neutrophilia.Ultrasound diagnosis can find that gollbladder dilation, cyst wall thicken, and visible calculus gets lodged in the cervical region of gallbladder.According to above symptom, physical examination and various auxiliary examination, doctor generally can make the diagnosis of acute cholecystitis in time.

Chronic cholecystitis is modal a kind of gallbladder disease, and patient generally has cholelithiasis simultaneously, but the chronic cholecystitis patient without calculus sees Chinese quite a few.Chronic cholecystitis can be the sequela of acute cholecystitis sometimes, but most patient did not suffer from acute cholecystitis in the past, due to gallbladder persistent inflammatory, gallbladder wall can occur fiber to thicken, cicatrix shrinks, and causes atrophy of gallbladder, and blister cavities can be of completely closed, cause that gallbladder function goes down, even completely lose function.

Chronic cholecystitis is common in China, women sickness rate is high, and female and man's ratio are 2-3:1, the various complexity of its cause of disease, the factors such as including age, sex, race, dietary habit, obesity, heredity, biliary tract infection, cholestasis, mostly is the result of comprehensive factor effect.

Along with the improvement of our people's growth in the living standard and sanitary condition, national average life extends nearly ten years, and the sickness rate of cholelithiasis increases day by day, and especially big city is increased and become apparent from, and accounts for the 70% of whole cholelithiasis according to statistics.

Chronic cholecystitis has course of disease length and the feature of easily recurrence, and patient's thickening of capsule wall of gallbladder, muscular tissue atrophy, gallbladder contraction function goes down, and cardinal symptom shows as right flank portion pain discomfort, abdominal distention, belch, anorexia is greasy, gastral cavilty portion is scorching hot.Modern medicine is thought, the cause of disease of chronic cholecystitis is mainly calculus stimulation, antibacterial infection, parasite, chemical stimulation and acute cholecystitis recurrent exerbation delay etc., and to spirit, psychological, social factor is relevant.It it is a kind of clinical common and frequently-occurring disease.

The clinical manifestation of chronic cholecystitis is not true to type more, also inconspicuous.Being likely to often to have right upper quadrant of the abdomen dull pain, abdominal distention, belch at ordinary times, feel sick and the indigestion symptom such as anorexia greasy food, some patients then feel under right omoplate, right season rib or right waist etc. dull pain.Standing, moving and becoming apparent from after psychrolusia.There is mild tenderness under patient's upper right abdominal rib edge, or pressure have sense of discomfort.The visible gallbladder of ultrasound diagnosis is noticeable or increases, air emptying function obstacle.When oral cholecystographic agent finds there is calculus, then diagnosis may determine that.

Clinical manifestation according to chronic cholecystitis, this disease belongs to the categories such as motherland's medical science " gallbladder-distention ", " hypochondriac pain ", " jaundice ", says " gallbladder-distention person, pain over the hypochondrium is swollen, bitter in mouth, sighing frequently " such as " Ling Shu Miraculous Pivot or Divine Axis is swollen opinion ".Liver and gall are the exterior and the interior each other, liver controlling conveyance and dispersion, and gallbladder is the fu-organ that contains refined juice, and chronic cholecystitis disease position, at gallbladder, centered by liver and gall, relates to taste.The traditional Chinese medical science is thought to invade in many, the insect poison improper by eating and drinking without temperance, disorder of emotion, depression of liver-QI, work and rest of chronic cholecystitis morbidity etc. and is caused, and causes liver and gall disorder of QI movement, humid-heat stagnation, qi depression to blood stasis, and dysfunction of the spleen in transportation decocts bile, yin and yang qi and blood disorder.Basic pathogenesis can be attributed to damp-heat accumulation, disorder of QI movement.

Treatment for chronic cholecystitis, doctor trained in Western medicine mainly has expectant treatment and operative treatment, expectant treatment generally takes light diet, antibacterial therapy, anti-inflammatory and choleretic, spasmolysis and analgesia, litholytic therapy etc., if drug main Long-term Oral Cholagogue drug, such as XIAOYAN LIDAN PIAN, Fel Ursi capsule, state good anethol trithione, bilocid etc., there is the deficiencies such as unsatisfactory curative effect, treatment time length, side effect are big in it.Operative treatment is for extracing sufferer gallbladder.Chinese medicine treatment chronic cholecystitis method generally has for oral administration or external used medicine, medicament fumigating, acupuncture therapy etc., think that gallbladder is one of six internal organs, the six hollow viscera must keep its unobstructed, so-called " pain is then obstructed ", therefore Chinese traditional treatment is many with " leading to " for method, by methods such as clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling, warming yang for activating qi-flowing, invigorating the spleen and benefiting QI, depressed liver-energy dispersing and function of gallbladder promoting, adjust the heresy of the stagnation of QI of smooth liver and gall, humid-heat stagnation of removing heat by catharsis, make poison heresy go and recover.

Chinese medicine is the precious legacy of China, by the adjustment effect to whole body entirety internal organs, improves body's immunity, plays the disease-resistant potential of human body.Active ingredient of Chinese herbs ubiquity immunological enhancement, immunosuppressant or dual regulation, biological effect is directly related with immunological network widely for it.Compared with synthetic drug, Chinese medicine has that untoward reaction is few, toxic and side effects is little and is not likely to produce the advantages such as drug resistance, is good biological response modifier.Therefore, herbal composite treatment chronic cholecystitis is adopted to become a new focus of people's research.

Summary of the invention

The present invention is directed to weak point of the prior art, it is provided that a kind of prepare simplicity, cost is low, evident in efficacy, the pharmaceutical composition for the treatment of chronic cholecystitis that has no side effect and preparation method thereof.

The above-mentioned purpose of the present invention is realized by following technical proposals:

A kind of pharmaceutical composition treating chronic cholecystitis, the crude drug of described pharmaceutical composition is made up of Herba Lysimachiae, Cortex Magnoliae Officinalis, Fructus Gardeniae (parched), Fructus Toosendan, Fructus Piperis Longi, Flos Rosae Rugosae, Endothelium Corneum Gigeriae Galli, Caulis Bambusae In Taenia, Herba Gentianopsis Paludosae, Concha Ostreae, Herba Lythri Salicariae, Radix Seu Caulis Mucunae Sempervirentis, Radix Sanguisorbae, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), Radix Cucurbitae, Semen Coicis, Herba Violae dissectae, Folium Et Cacumen Murrayae, Fructus Lycii, Semen Cassiae, Semen Vaccariae, Rhizoma Acori Graminei, Radix Rubiae, Ramulus Cinnamomi, Pericarpium Citri Reticulatae Viride, Fructus Crataegi, Radix Glycyrrhizae, Herba Taraxaci, Herba Hedyotidis Diffusae, Semen Plantaginis, Ramulus Salicis Babylonicae, Radix Polygoni Multiflori Preparata, Radix Saposhnikoviae.

nullFurther，Make described pharmaceutical composition raw material composition and parts by weight be: Herba Lysimachiae 12-20 part，Cortex Magnoliae Officinalis 10-16 part，Fructus Lycii 3-8 part，Fructus Gardeniae (parched) 5-12 part，Fructus Piperis Longi 12-17 part，Fructus Toosendan 7-12 part，Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 4-9 part，Endothelium Corneum Gigeriae Galli 15-20 part，Caulis Bambusae In Taenia 10-15 part，Concha Ostreae 8-12 part，Herba Lythri Salicariae 2-5 part，Flos Rosae Rugosae 3-7 part，Radix Seu Caulis Mucunae Sempervirentis 11-14 part，Radix Sanguisorbae 9-15 part，Semen Vaccariae 3-6 part，Radix Cucurbitae 8-13 part，Herba Violae dissectae 3-5 part，Folium Et Cacumen Murrayae 1-3 part，Rhizoma Acori Graminei 5-10 part，Herba Gentianopsis Paludosae 5-10 part，Radix Rubiae 13-16 part，Ramulus Cinnamomi 3-10 part，Pericarpium Citri Reticulatae Viride 8-13 part，Fructus Crataegi 3-5 part，Semen Coicis 1-3 part，Radix Glycyrrhizae 5-10 part，Semen Cassiae 3-6 part，Herba Taraxaci 8-13 part，Herba Hedyotidis Diffusae 3-5 part，Semen Plantaginis 11-15 part，Ramulus Salicis Babylonicae 5-10 part，Radix Polygoni Multiflori Preparata 2-5 part，Radix Saposhnikoviae 4-9 part.

Further, make described pharmaceutical composition raw material composition and parts by weight be: Herba Lysimachiae 12 parts, Cortex Magnoliae Officinalis 16 parts, Fructus Lycii 3 parts, Fructus Gardeniae (parched) 12 parts, Fructus Piperis Longi 12 parts, Fructus Toosendan 10 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 9 parts, Endothelium Corneum Gigeriae Galli 15 parts, Caulis Bambusae In Taenia 15 parts, Concha Ostreae 8 parts, Herba Lythri Salicariae 5 parts, Flos Rosae Rugosae 3 parts, Radix Seu Caulis Mucunae Sempervirentis 14 parts, Radix Sanguisorbae 9 parts, Semen Vaccariae 6 parts, Radix Cucurbitae 8 parts, Herba Violae dissectae 5 parts, Folium Et Cacumen Murrayae 1 part, Rhizoma Acori Graminei 10 parts, Herba Gentianopsis Paludosae 5 parts, 16 parts of Radix Rubiae, Ramulus Cinnamomi 10 parts, 8 parts of Pericarpium Citri Reticulatae Viride, Fructus Crataegi 5 parts, Semen Coicis 1 part, 10 parts of Radix Glycyrrhizae, Semen Cassiae 6 parts, Herba Taraxaci 8 parts, Herba Hedyotidis Diffusae 3 parts, Semen Plantaginis 15 parts, Ramulus Salicis Babylonicae 5 parts, Radix Polygoni Multiflori Preparata 3 parts, Radix Saposhnikoviae 5 parts.

Further, make described pharmaceutical composition raw material composition and parts by weight be: Herba Lysimachiae 20 parts, Cortex Magnoliae Officinalis 10 parts, Fructus Lycii 8 parts, Fructus Gardeniae (parched) 5 parts, Fructus Piperis Longi 17 parts, Fructus Toosendan 12 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 4 parts, Endothelium Corneum Gigeriae Galli 20 parts, Caulis Bambusae In Taenia 10 parts, Concha Ostreae 12 parts, Herba Lythri Salicariae 2 parts, Flos Rosae Rugosae 7 parts, Radix Seu Caulis Mucunae Sempervirentis 11 parts, Radix Sanguisorbae 15 parts, Semen Vaccariae 3 parts, Radix Cucurbitae 13 parts, Herba Violae dissectae 3 parts, Folium Et Cacumen Murrayae 3 parts, Rhizoma Acori Graminei 5 parts, Herba Gentianopsis Paludosae 10 parts, 13 parts of Radix Rubiae, Ramulus Cinnamomi 3 parts, 13 parts of Pericarpium Citri Reticulatae Viride, Fructus Crataegi 3 parts, Semen Coicis 3 parts, 5 parts of Radix Glycyrrhizae, Semen Cassiae 4 parts, Herba Taraxaci 10 parts, Herba Hedyotidis Diffusae 4 parts, Semen Plantaginis 13 parts, Ramulus Salicis Babylonicae 6 parts, Radix Polygoni Multiflori Preparata 4 parts, Radix Saposhnikoviae 8 parts.

Further, make described pharmaceutical composition raw material composition and parts by weight be: Herba Lysimachiae 13 parts, Cortex Magnoliae Officinalis 11 parts, Fructus Lycii 4 parts, Fructus Gardeniae (parched) 6 parts, Fructus Piperis Longi 13 parts, Fructus Toosendan 7 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 5 parts, Endothelium Corneum Gigeriae Galli 18 parts, Caulis Bambusae In Taenia 11 parts, Concha Ostreae 9 parts, Herba Lythri Salicariae 4 parts, Flos Rosae Rugosae 6 parts, Radix Seu Caulis Mucunae Sempervirentis 12 parts, Radix Sanguisorbae 13 parts, Semen Vaccariae 4 parts, Radix Cucurbitae 9 parts, Herba Violae dissectae 4 parts, Folium Et Cacumen Murrayae 2 parts, Rhizoma Acori Graminei 6 parts, Herba Gentianopsis Paludosae 6 parts, 14 parts of Radix Rubiae, Ramulus Cinnamomi 5 parts, 10 parts of Pericarpium Citri Reticulatae Viride, Fructus Crataegi 4 parts, Semen Coicis 2 parts, 6 parts of Radix Glycyrrhizae, Semen Cassiae 5 parts, Herba Taraxaci 12 parts, Herba Hedyotidis Diffusae 3 parts, Semen Plantaginis 12 parts, Ramulus Salicis Babylonicae 9 parts, Radix Polygoni Multiflori Preparata 4 parts, Radix Saposhnikoviae 7 parts.

Further, make described pharmaceutical composition raw material composition and parts by weight be: Herba Lysimachiae 17 parts, Cortex Magnoliae Officinalis 15 parts, Fructus Lycii 7 parts, Fructus Gardeniae (parched) 11 parts, Fructus Piperis Longi 16 parts, Fructus Toosendan 8 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 8 parts, Endothelium Corneum Gigeriae Galli 16 parts, Caulis Bambusae In Taenia 14 parts, Concha Ostreae 11 parts, Herba Lythri Salicariae 3 parts, Flos Rosae Rugosae 5 parts, Radix Seu Caulis Mucunae Sempervirentis 13 parts, Radix Sanguisorbae 14 parts, Semen Vaccariae 5 parts, Radix Cucurbitae 12 parts, Herba Violae dissectae 3 parts, Folium Et Cacumen Murrayae 1 part, Rhizoma Acori Graminei 10 parts, Herba Gentianopsis Paludosae 9 parts, 13 parts of Radix Rubiae, Ramulus Cinnamomi 7 parts, 11 parts of Pericarpium Citri Reticulatae Viride, Fructus Crataegi 3 parts, Semen Coicis 1 part, 10 parts of Radix Glycyrrhizae, Semen Cassiae 4 parts, Herba Taraxaci 11 parts, Herba Hedyotidis Diffusae 4 parts, Semen Plantaginis 14 parts, Ramulus Salicis Babylonicae 8 parts, Radix Polygoni Multiflori Preparata 3 parts, Radix Saposhnikoviae 6 parts.

Further, make described pharmaceutical composition raw material composition and parts by weight be: Herba Lysimachiae 15 parts, Cortex Magnoliae Officinalis 12 parts, Fructus Lycii 5 parts, Fructus Gardeniae (parched) 9 parts, Fructus Piperis Longi 15 parts, Fructus Toosendan 9 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 7 parts, Endothelium Corneum Gigeriae Galli 19 parts, Caulis Bambusae In Taenia 13 parts, Concha Ostreae 10 parts, Herba Lythri Salicariae 4 parts, Flos Rosae Rugosae 4 parts, Radix Seu Caulis Mucunae Sempervirentis 11 parts, Radix Sanguisorbae 11 parts, Semen Vaccariae 5 parts, Radix Cucurbitae 10 parts, Herba Violae dissectae 5 parts, Folium Et Cacumen Murrayae 3 parts, Rhizoma Acori Graminei 8 parts, Herba Gentianopsis Paludosae 8 parts, 14 parts of Radix Rubiae, Ramulus Cinnamomi 9 parts, 12 parts of Pericarpium Citri Reticulatae Viride, Fructus Crataegi 5 parts, Semen Coicis 3 parts, 8 parts of Radix Glycyrrhizae, Semen Cassiae 6 parts, Herba Taraxaci 9 parts, Herba Hedyotidis Diffusae 5 parts, Semen Plantaginis 12 parts, Ramulus Salicis Babylonicae 7 parts, Radix Polygoni Multiflori Preparata 5 parts, Radix Saposhnikoviae 9 parts.

Further, make described pharmaceutical composition raw material composition and parts by weight be: Herba Lysimachiae 19 parts, Cortex Magnoliae Officinalis 14 parts, Fructus Lycii 6 parts, Fructus Gardeniae (parched) 7 parts, Fructus Piperis Longi 14 parts, Fructus Toosendan 9 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 6 parts, Endothelium Corneum Gigeriae Galli 17 parts, Caulis Bambusae In Taenia 13 parts, Concha Ostreae 10 parts, Herba Lythri Salicariae 4 parts, Flos Rosae Rugosae 4 parts, Radix Seu Caulis Mucunae Sempervirentis 11 parts, Radix Sanguisorbae 11 parts, Semen Vaccariae 5 parts, Radix Cucurbitae 10 parts, Herba Violae dissectae 5 parts, Folium Et Cacumen Murrayae 3 parts, Rhizoma Acori Graminei 8 parts, Herba Gentianopsis Paludosae 8 parts, 14 parts of Radix Rubiae, Ramulus Cinnamomi 4 parts, 9 parts of Pericarpium Citri Reticulatae Viride, Fructus Crataegi 5 parts, Semen Coicis 3 parts, 8 parts of Radix Glycyrrhizae, Semen Cassiae 3 parts, Herba Taraxaci 8 parts, Herba Hedyotidis Diffusae 5 parts, Semen Plantaginis 15 parts, Ramulus Salicis Babylonicae 7 parts, Radix Polygoni Multiflori Preparata 2 parts, Radix Saposhnikoviae 4 parts.

The preparation method that the invention still further relates to a kind of pharmaceutical composition treating chronic cholecystitis, comprises the steps:

(1) taking each medical material of components by weight percent in arbitrary described pharmaceutical composition, first time decocts the water boiling and extraction of 10-15 times that adds medical material gross weight, decocts 1-2 hour: second time adds the water of 8-12 times amount, decocts 1-1.2h, leaches medicinal liquid stand-by；Third time adds the water of 8-12 times amount, decocts 0.8-1.2h, leaches medicinal liquid stand-by；Merging three decocting liquids, filter, collect filtrate, being concentrated into relative density when 50-60 DEG C is the clear paste of 1.10-1.30；

(2) clear paste that step (1) prepares is placed to room temperature, add ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to stand 24-48 hour, take supernatant；Supernatant reclaims ethanol, and being evaporated to relative density when 50-60 DEG C is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently；At 60 DEG C of-80 DEG C of spray drying, obtain dry extract；

(3) dry extract that step (2) prepares is pulverized, add suitable amount of sucrose, dextrin mixing, with ethanol for wetting agent, granulate, dry, granulate, granule can be prepared；Or the dry extract that step (2) prepares be dry, pulverize, make powder；Or dry extract step (2) prepared is pulverized, add appropriate micropowder silica gel, α-galactose mixing, with ethanol for wetting agent, granulate, dry, granulate, encapsulated, prepare capsule；Or dry extract step (2) prepared is pulverized, add suitable amount of sucrose, dextrin mixing, with ethanol for wetting agent, granulate, dry, granulate, tabletting, prepare tablet；Or to above-mentioned steps (2) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, prepare medicinal liquid agent.

The invention still further relates to the application in treatment chronic cholecystitis medicine of a kind of described pharmaceutical composition.

The pharmaceutical composition for the treatment of chronic cholecystitis provided by the present invention, it gives full play to the property of medicine of each component with common Chinese herbal medicine for raw material:

Herba Lysimachiae: sweet in the mouth, micro-hardship, cool in nature.Return liver, gallbladder, kidney, bladder warp.Function cures mainly: relieving stranguria by diuresis；Heat-clearing and toxic substances removing；Dissipating blood stasis for subsidence of swelling.Cure mainly liver and gall and urinary system calculus；Pyretic stranguria；Oedema due to nephritis；Jaundice due to damp-heat；Sore carbuncle；Venom；Traumatic injury.

Cortex Magnoliae Officinalis, bitter in the mouth, pungent, warm in nature；Return spleen, stomach, lung, large intestine channel.Having circulation of qi promoting removing food stagnancy, dampness is removed full, effect of lowering the adverse QI to relieve asthma.

Fructus Gardeniae (parched), bitter, cold.GUIXIN, lung, tri-jiao channel.Cure mainly pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles；External treatment bruise pain.

Fructus Toosendan: Chinese crude drug, for the mature fruit of Meliaceae deciduous tree toosendanin, cold in nature, bitter in the mouth, is the one of qi-activating drug.There are soothing liver-QI promoting the circulation of QI to relieve pain, the drug effect of anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.But also be make the efficient important source material without the free of contamination novel plant pesticide of residual hazard.Fructus Toosendan bitter cold settles, and mainly enters Liver Channel, catharsis liver-heat, promoting the circulation of QI to relieve pain, controls the stagnation of QI and has demonstrate,proving of heat especially suitable.

Fructus Piperis Longi: for analgesia stomachic, the big temperature of acrid in the mouth, nontoxic.For stomachache, acid regurgitation, diarrhoea, angina pectoris, nervous headache and toothache etc. that cold syndrome of the stomach causes.Warming the middle warmer and descending qi, mends waist foot, kills stink smell, help digestion, and except stomach is cold, scrotal hernia and chest and abdomen are bitterly.Control cholera cold air, pained vim and vigour, watery diarrhea dysentery of deficiency type, vomiting acid regurgitation, puerperal dysentery, share better with Resina Ferulae.With Fructus Chebulae, Radix Ginseng, Cortex Cinnamomi, Rhizoma Zingiberis, control internal organs cold caused by deficiency borborygmus, control again headache, nasal obstruction, tenderness.The fire of active spleen lung, multiplex makes us blurred vision.Its root name Bi Bohai Sea does not have, acrid in the mouth, warm in nature and, nontoxic.Treatment five kinds of strain and seven kinds of impairment, cold air is vomitted, trusted subordinate's distension, dyspepsia, the embedding edema of polyhidrosis around the external genitals hernia, married woman's infertility.Control waist kidney cold, except vim and vigour.

Flos Rosae Rugosae: road in " book on Chinese herbal medicine text ": " Flos Rosae Rugosae, turbid clearly and not, and and violent, easing the affected liver is waken up stomach, and thin gas is invigorated blood circulation, and a surname is logical stops up stagnant and that absolutely not pungent temperature is just dry fraud, disconnected pushes away among edema caused by disorder of QI medicine, has prompt effect most and the most tractable, fragrant all product, and there is no equal ".Sweet and slightly bitter taste, slightly warm in nature, return liver, spleen, stomach warp.

Endothelium Corneum Gigeriae Galli: the taste of chicken are also.In have porcelain stone, copper, ferrum all can digest, its kind blood stasis dispelling is amassed known.(taste) are placed in the middle burnt to lift gasification, if there being the stasis of blood to amass, gasification can not lift, and is easily cause distension, is organotherapy with Endothelium Corneum Gigeriae Galli.If again with Rhizoma Atractylodis Macrocephalae decile use, for the key medicine that the digestion stasis of blood is long-pending, the more quality goods of strengthening the spleen and stomach, taste are healthy and strong, and the benefit energy transporting efficacy of a drug is with removing food stagnancy also.Not only can diabetes with polyphagia as the prominent symptom stomach long-pending, no matter internal organs where has long-pending, and Endothelium Corneum Gigeriae Galli all can disappear it, is with man's mass beside the umbilicus, woman's lump in the abdomen, takes it for a long time, all can cure.The card of all asthenia again, the many stasis of bloods of its meridians are stagnant, add Endothelium Corneum Gigeriae Galli in tonic, and the stasis of blood to change its meridians is stagnant, and disease begins more.

Caulis Bambusae In Taenia: nature and flavor cold nature, sweet in the mouth.Function cures mainly: removing heat-phlegm, relieves restlessness and prevents vomiting.Expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement is held under the arm for phlegm-heat cough, gallbladder fire.

Herba Gentianopsis Paludosae: herb treatment jaundice, liver and gall heat, headache, lung-heat, gastric heat, has a fever " illiteracy plants medicine will ".Craze for Japanese pop culture-Te wood day-ground lattice reach, and prick various places each: herb is for " uncommon day " hot eye, urine, Dermal icterus, new liver-heat for a long time, hepatic injury, and liver blood rises, " uncommon day " property pneumonopathy, have a headache, vomiting of drinking, gastric acid pain " ethnic drug will three ".Craze for Japanese pop culture spy's wood that-ground lattice: curing mainly liver and gall heat, jaundice, heat in blood is had a headache, fever, xerostomia, gastric heat.

Concha Ostreae: " Bencao Jingshu ": Concha Ostreae salty in the mouth is put down, feeble QI is trembled with fear, nontoxic, enters foot few the moon, the moon of fainting, shaoyang channel.Its main typhoid fever cold and heat, pyrexial malaria be voluminous, frightened gas of being enraged, stays heat to remove under indefinite, stuffy sensation with restlessness, depressed pained, the heart side of body cards such as painful abdominal mass heat in joint, and all liver and gall two are through for disease.Two are subject to cold-evil through the winter, then be typhoid fever cold and heat；Being attacked by pathogenic heat in summer, then be that pyrexial malaria is voluminous；Evil lie prostrate not go out, then hot go in joint indefinite；Two do not dissipate through evil strongly fragrant, then the lower painful abdominal mass of the heart side of body；Very, then frightened gas of being enraged, stuffy sensation with restlessness is depressed pained for pathogenic heat heat.The salty gas of these flavour of a drug is trembled with fear, and enters two warps and removes cold and heat pathogen, then battalion defends logical, arrests and relaxes, and all cards recover invariably.Few the moon has heat, then woman be that leukorrhagia is red in vain, and man, for letting out essence, solves the heat lacking the moon, and can hold back arresting seminal emission gas, thus main also.

Herba Lythri Salicariae is the herb of Lythraceae plant Herba Lythri Salicariae.Sweet in the mouth, hardship, cold in nature.Return large intestine, Liver Channel.Function removing blood stasis with potent drugs stimulates the menstrual flow, clearing away heat and cooling blood, heat clearing away poison.

Radix Seu Caulis Mucunae Sempervirentis is the stem of the evergreen mucuna of leguminous plant.Bitter in the mouth, warm in nature.Return liver, stomach warp.Function blood circulation promoting and blood stasis dispelling, promoting blood flow to regulate menstruation, promoting the circulation of blood is enriched blood, dredge the meridian passage.For traumatic injury, rheumatalgia, numbness, stimulate the menstrual flow, amenorrhea.

Radix Sanguisorbae property of medicine picric acid；Cold；Nontoxic, return liver；Lung；Kidney；Large intestine channel, effect cooling blood for hemostasis, heat-clearing and toxic substances removing, sore of subsiding a swelling.Effect classification hemorrhage；Blood-cooling hemostatic.Cure mainly haematemesis, spitting of blood, epistaxis, hematuria, have blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, leucorrhea with red and white discharge, sore, carbuncle and painful swelling, eczema, pudendal pruritus, burn due to hot liquid or fire, snake bite and insect sting.

Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) is the herb of Ofthe Primulaceae tiger tail Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis).Bitter in the mouth, pungent, property is put down.Return liver, spleen channel.Function promoting blood circulation to remove blood stasis, clearing away heat-damp and promoting diuresis, removing toxicity for eliminating carbuncles.

Radix Cucurbitae is the root of cucurbitaceous plant Fructus Cucurbitae moschatae.Sweet in the mouth, light, property is put down.Return liver, bladder warp.Function dampness removing heat, clear jaundice, promoting lactation, logical wet pouring.

Semen Coicis: enter spleen, lung, kidney channel.Spleen invigorating, tonifying the lung, heat clearing away, dampness removing.Control and have loose bowels, arthralgia chiefly caused by damp pathogen, muscle arteries and veins contracture, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea.

Herba Violae dissectae is the Herb of Violaceae plant decomposite leaf common violet.Bitter in the mouth, cold in nature.Enter the heart, gallbladder, spleen, Liver Channel.Function heat-clearing and toxic substances removing, repercussive eliminating stagnation, detumescence poison.

Folium Et Cacumen Murrayae is leaf and the band leaf twig of rutaceae Folium Et Cacumen Murrayae and Murraya paniculata (L.) Jack..Acrid in the mouth, micro-hardship, warm in nature.GUIXIN, liver, lung meridian.Function promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain.

Fructus Lycii, sweet, flat.Return liver, kidney channel.Nourishing the liver and kidney, benefit intensive culture blood, improving eyesight removing nebula, nourishing the lung to arrest cough.The diseases such as curing mainly the atrophic debility of bones of suffering from a deficiency of the kidney, impotence and seminal emission, fertility of a specified duration, senilism senilism, early whitening of beard and hair, blood deficiency and yellow complexion, puerperal, breast was few, poor vision, interior external oculopathy eye, and interior-heat is quenched one's thirst, consumptive fever hectic fever due to YIN-deficiency, and chronic consumptive disease is coughed, the few expectorant of dry cough.

Semen Cassiae is the mature seed of leguminous plant Semen Cassiae, is also known as Semen Cassiae.Shennong's Herbal is recorded Semen Cassiae sweetness and bitterness and is slightly cold, and returns liver, gallbladder, kidney three warp, has liver heat removing and eyesight improving, loosening bowel to relieve constipation, the function of lipid-lowering weight-reducing, can be used for dizziness of having a headache, and conjunctival congestion is dim-sighted, constipation etc., in recent years clinically again for the treatment of hypertension.Semen Cassiae, containing anthraglycosides material, produces rheum emodin, physcione, chrysophanic acid, chrysophanol and glucose etc. after decomposition.It is demonstrated experimentally that Semen Cassiae has blood pressure lowering, blood fat reducing, the effect such as antibacterial, being used for treating hyperlipemia has certain curative effect.Except medicinal ingredient, Semen Cassiae is possibly together with multivitamin and abundant aminoacid, carbohydrate etc..

Semen Vaccariae: bitter in the mouth, property are flat, return stomach warp, have effect of promoting blood circulation to restore menstrual flow stimulating milk secretion, is good at promoting blood circulation, goes and does not walk, walks and do not keep, and upper energy promoting lactation, lower energy leads to amenorrhea.

Rhizoma Acori Graminei: pungent, bitter, temperature.GUIXIN, stomach warp.Effect with cure mainly: removing dampness whet the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, the insane disease of coma, forgetful deafness.

Radix Rubiae: cold in nature, bitter in the mouth, there is cooling blood for hemostasis, effect that blood stasis dispelling stimulates the menstrual flow, especially suitable for the hemorrhage of bleeding due to blood-heat, the congestion person that holds concurrently, for stasis of blood stagnate-closed warp, postpartum stagnation stomachache, treating swelling and pain by traumatic injury, rheumatic arthralgia etc. are demonstrate,proved.

Ramulus Cinnamomi: nature and flavor acrid, sweet, warm, GUIXIN, lung, bladder warp；Effect: diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain, must not warm logical card for yang deficiency.

Pericarpium Citri Reticulatae Viride: bitter in the mouth, pungent, warm in nature, enter liver, gallbladder, stomach warp, there is the effect that easypro gallbladder dispelling the stagnated QI, removing food stagnancyization are stagnant, for stagnation of QI due to dyspepsia, abdominal distention, infantile malnutrition, old man stops eating abdominal distention, gastrointestinal tract is had the stimulation of gentleness, can facilitating digestion liquid secretion and get rid of internal gas, again can diastole gastrointestinal smooth muscle, main manifestations be adjust gastrointestinal function effect.

Fructus Crataegi is the fruit of Flos Rosae Multiflorae tannin plant Fructus Crataegi or Crataegi cuneatae, and it is sour, sweet, tepor, enters spleen, stomach, Liver Channel, have help digestion long-pending, dissipating blood stasis blood, diuresis, effect of antidiarrheal.After human body takes Fructus Crataegi, by increasing capacitance it is possible to increase the activity of enzyme in stomach, promote food digestion, circulation of qi promoting dissipating blood stasis, be beneficial to the meat that disappears and amass.

Radix Glycyrrhizae: sweet in the mouth, returns 12 warps.Have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic is so that the pharmacological action such as anticancer.In the traditional Chinese medical science, Radix Glycyrrhizae invigorating the spleen and replenishing QI, to grow and cough lung moistening, emergency is detoxified, and is in harmonious proportion hundred medicines.

Herba Taraxaci: for feverfew Herba Taraxaci TaraxacummongolicumHand.-Mazz., alkali ground Herba Taraxaci TaraxacumsinicumKitag. or the dry herb belonging to several plants together.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.

Herba Hedyotidis Diffusae: bitter in the mouth, sweet, cold in nature, enter the heart, liver, spleen, large intestine channel, there is heat-clearing and toxic substances removing, the effect of promoting diuresis to eliminate damp pathogen, for dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom, the puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, the card such as cancerous protuberance.

Semen Plantaginis: clearing away heat and promoting diuresis；Eliminating dampness by diuresis antidiarrheal；Improving eyesight；Eliminate the phlegm.Cure mainly: main dysuria；Stranguria with turbid discharge leukorrhagia；Edema distension；Heat-damp in summer dysentery；Conjunctival congestion is hidden from view；Expectorant heat syndrome cough is breathed heavily.Select the seed for Plantaginaceae plant Herba Plantaginis Big Semen Plantaginis and Plantago depressa Willd.

Ramulus Salicis Babylonicae: dispel the wind, diuresis, pain relieving, detumescence.Dispelling the wind and dampness pathogens arthralgia pain, gonorrhea, nebulousurine, urinary obstruction, infectious hepatitis, swelling due to wind, furuncle, erysipelas, dental caries, swelling of the gum.Select the dry branch of Salicaceous Plants Salix babylonica L..

Radix Polygoni Multiflori Preparata: for the Preparation process product of the dried root of polygonum multiflorum thunb PolygonummultiflorumThunb..Nature and flavor are bitter, sweet, puckery, tepor.Return liver, the heart, kidney channel.Effect: invigorating the liver and kidney, benefiting essence-blood, crow beard and hair, bone and muscle strengthening.

Radix Saposhnikoviae, nature and flavor: acrid in the mouth, sweet, slightly warm in nature, there is expelling pathogenic wind from the body surface, effect that removing dampness to relieve pain, relieving convulsion are jerked surely, be used for treating diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus.

The traditional Chinese medical science is thought, chronic cholecystitis, belongs to the sick category such as the traditional Chinese medical science " gallbladder-distention ", " hypochondriac pain ".The traditional Chinese medical science thinks that liver is one of the five internal organs, main store blood, main catharsis, and property happiness bar reaches and dislikes depression.Gallbladder is internal organs, main store essential substances juice, to lead to for use, suitable to reduce to.Liver and gall are the exterior and the interior each other, and bile leading to drops, and depends on the catharsis of liver, and gallbladder internal organs function is normal, is conducive to the bar of liver to reach.If feelings will is not relaxed, irritability stasis, or daily life is careless, damp and hot heresy invasion and attack gallbladder internal organs；Or eating and drinking without temperance, have a liking for the product of greasy delicious food, lead to damp and hot, interior stream gallbladder internal organs, all can cause liver and gall and become estranged, logical drop unfavorable, mechanism of qi retardance and raw pain, swollen all diseases.Moist sticky, in addition liver and gall depression and stagnation of QI, the symptoms such as transporting and transforming function of the spleen and stomach is not good for, inside and outside phase factor, often causes protracted inflammation or recurrent exerbation, and touching difficulty more, then becomes liver and gall to become estranged, the damp and hot card being detained, and upper abdomen or distending pain over the hypochondrium occurs, right pain in the shoulder and back, abdominal distention and little diet, bitter taste, greasy fur.In the course of disease, liver and gall are become estranged, irritability stasis, may result in insufficiency of the spleen transporting too late, water-damp retention, and damp-stagnancy heat-transformation, may result in again stagnation of liver-QI and lose thin, and logical the dropping of bile is obstructed, and is thusly-formed vicious cycle, then disease is delayed repeatedly, not easily cures.Pathogenesis it is critical only that liver and gall are become estranged, and damp and hot is detained, and medicine for treatment, outside depressed liver-energy dispersing and function of gallbladder promoting, should pay attention to invigorating spleen to remove dampness, makes liver dredge spleen fortune, and mechanism of qi bar reaches, transporting and transforming function of the spleen and stomach is had the right, then damp and hot raw, gallbladder internal organs is peaceful clearly, radically reform thus reaching to effect a permanent cure, treating both the principal and secondary aspects of a disease purpose.

The pharmaceutical composition compatibility of the treatment chronic cholecystitis of the present invention is based on Chinese medicine " monarch " principle, all medicines share can clearing liver-gallbladder, soothing the liver circulation of qi promoting, regulating functional activities of qi, effect of heat-clearing and toxic substances removing, tranquilizing by nourishing the heart, invigorating the spleen and benefiting QI, clearing heat secreting bile played altogether by all medicines, reach the purpose for the treatment of chronic cholecystitis, and overcome the defect of the length course for the treatment of that Modern medical therapy chronic cholecystitis has, poor effect, easily recurrence.

Detailed description of the invention

For making the purpose of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with embodiment, technical scheme is clearly and completely described.Obviously, described embodiment is the part of the present invention, rather than whole embodiments.Based on described embodiments of the invention, the every other embodiment that those of ordinary skill in the art obtain under the premise without creative work, broadly fall into the scope of protection of the invention.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.

Embodiment 1:

A kind of pharmaceutical composition treating chronic cholecystitis of the present invention, take following traditional Chinese medicine raw medicine: Herba Lysimachiae 12 grams, Cortex Magnoliae Officinalis 16 grams, Fructus Lycii 3 grams, Fructus Gardeniae (parched) 12 grams, Fructus Piperis Longi 12 grams, Fructus Toosendan 10 grams, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 9 grams, Endothelium Corneum Gigeriae Galli 15 grams, Caulis Bambusae In Taenia 15 grams, Concha Ostreae 8 grams, Herba Lythri Salicariae 5 grams, Flos Rosae Rugosae 3 grams, Radix Seu Caulis Mucunae Sempervirentis 14 grams, Radix Sanguisorbae 9 grams, Semen Vaccariae 6 grams, Radix Cucurbitae 8 grams, Herba Violae dissectae 5 grams, Folium Et Cacumen Murrayae 1 gram, Rhizoma Acori Graminei 10 grams, Herba Gentianopsis Paludosae 5 grams, 16 grams of Radix Rubiae, Ramulus Cinnamomi 10 grams, 8 grams of Pericarpium Citri Reticulatae Viride, Fructus Crataegi 5 grams, Semen Coicis 1 gram, 10 grams of Radix Glycyrrhizae, Semen Cassiae 6 grams, Herba Taraxaci 8 grams, Herba Hedyotidis Diffusae 3 grams, Semen Plantaginis 15 grams, Ramulus Salicis Babylonicae 5 grams, Radix Polygoni Multiflori Preparata 3 grams, Radix Saposhnikoviae 5 grams.

The preparation method of described Chinese medicine composition is:

(1) taking each medical material of components by weight percent in described Chinese medicine composition, first time decocts the water boiling and extraction of 10-15 times that adds medical material gross weight, decocts 1 hour: second time adds the water of 8 times amount, decocts 1h, leaches medicinal liquid stand-by；Third time adds the water of 8-12 times amount, decocts 1.2h, leaches medicinal liquid stand-by；Merging three decocting liquids, filter, collect filtrate, being concentrated into relative density when 50-60 DEG C is the clear paste of 1.30；

(2) clear paste that step (1) prepares is placed to room temperature, add ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to stand 24 hours, take supernatant；Supernatant reclaims ethanol, and being evaporated to relative density when 60 DEG C is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently；At 60 DEG C of-80 DEG C of spray drying, obtain dry extract；

(3) dry extract that step (2) prepares is pulverized, add suitable amount of sucrose, dextrin mixing, with ethanol for wetting agent, granulate, dry, granulate, granule can be prepared.

Embodiment 2:

A kind of pharmaceutical composition treating chronic cholecystitis of the present invention, take following traditional Chinese medicine raw medicine: Herba Lysimachiae 20 grams, Cortex Magnoliae Officinalis 10 grams, Fructus Lycii 8 grams, Fructus Gardeniae (parched) 5 grams, Fructus Piperis Longi 17 grams, Fructus Toosendan 12 grams, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 4 grams, Endothelium Corneum Gigeriae Galli 20 grams, Caulis Bambusae In Taenia 10 grams, Concha Ostreae 12 grams, Herba Lythri Salicariae 2 grams, Flos Rosae Rugosae 7 grams, Radix Seu Caulis Mucunae Sempervirentis 11 grams, Radix Sanguisorbae 15 grams, Semen Vaccariae 3 grams, Radix Cucurbitae 13 grams, Herba Violae dissectae 3 grams, Folium Et Cacumen Murrayae 3 grams, Rhizoma Acori Graminei 5 grams, Herba Gentianopsis Paludosae 10 grams, 13 grams of Radix Rubiae, Ramulus Cinnamomi 3 grams, 13 grams of Pericarpium Citri Reticulatae Viride, Fructus Crataegi 3 grams, Semen Coicis 3 grams, 5 grams of Radix Glycyrrhizae, Semen Cassiae 4 grams, Herba Taraxaci 10 grams, Herba Hedyotidis Diffusae 4 grams, Semen Plantaginis 13 grams, Ramulus Salicis Babylonicae 6 grams, Radix Polygoni Multiflori Preparata 4 grams, Radix Saposhnikoviae 8 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) taking each medical material of components by weight percent in described Chinese medicine composition, first time decocts the water boiling and extraction of 10-15 times that adds medical material gross weight, decocts 1-2 hour: second time adds the water of 12 times amount, decocts 1.2h, leaches medicinal liquid stand-by；Third time adds the water of 8-12 times amount, decocts 0.8-1.2h, leaches medicinal liquid stand-by；Merging three decocting liquids, filter, collect filtrate, being concentrated into relative density when 50-60 DEG C is the clear paste of 1.10；

(3) dry extract that step (2) prepares be dry, pulverize, make powder.

Embodiment 3:

A kind of pharmaceutical composition treating chronic cholecystitis of the present invention, take following traditional Chinese medicine raw medicine: Herba Lysimachiae 13 grams, Cortex Magnoliae Officinalis 11 grams, Fructus Lycii 4 grams, Fructus Gardeniae (parched) 6 grams, Fructus Piperis Longi 13 grams, Fructus Toosendan 7 grams, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 5 grams, Endothelium Corneum Gigeriae Galli 18 grams, Caulis Bambusae In Taenia 11 grams, Concha Ostreae 9 grams, Herba Lythri Salicariae 4 grams, Flos Rosae Rugosae 6 grams, Radix Seu Caulis Mucunae Sempervirentis 12 grams, Radix Sanguisorbae 13 grams, Semen Vaccariae 4 grams, Radix Cucurbitae 9 grams, Herba Violae dissectae 4 grams, Folium Et Cacumen Murrayae 2 grams, Rhizoma Acori Graminei 6 grams, Herba Gentianopsis Paludosae 6 grams, 14 grams of Radix Rubiae, Ramulus Cinnamomi 5 grams, 10 grams of Pericarpium Citri Reticulatae Viride, Fructus Crataegi 4 grams, Semen Coicis 2 grams, 6 grams of Radix Glycyrrhizae, Semen Cassiae 5 grams, Herba Taraxaci 12 grams, Herba Hedyotidis Diffusae 3 grams, Semen Plantaginis 12 grams, Ramulus Salicis Babylonicae 9 grams, Radix Polygoni Multiflori Preparata 4 grams, Radix Saposhnikoviae 7 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) taking each medical material of components by weight percent in described Chinese medicine composition, first time decocts the water boiling and extraction of 10-15 times that adds medical material gross weight, decocts 1-2 hour: second time adds the water of 8-12 times amount, decocts 1-1.2h, leaches medicinal liquid stand-by；Third time adds the water of 8-12 times amount, decocts 0.8h, leaches medicinal liquid stand-by；Merging three decocting liquids, filter, collect filtrate, being concentrated into relative density when 50-60 DEG C is the clear paste of 1.15；

(2) clear paste that step (1) prepares is placed to room temperature, add ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to stand 48 hours, take supernatant；Supernatant reclaims ethanol, and being evaporated to relative density when 50-60 DEG C is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently；At 60 DEG C of-80 DEG C of spray drying, obtain dry extract；

(3) dry extract that step (2) prepares is pulverized, add appropriate micropowder silica gel, α-galactose mixing, with ethanol for wetting agent, granulate, dry, granulate, encapsulated, prepare capsule.

Embodiment 4:

A kind of pharmaceutical composition treating chronic cholecystitis of the present invention, take following traditional Chinese medicine raw medicine: Herba Lysimachiae 17 grams, Cortex Magnoliae Officinalis 15 grams, Fructus Lycii 7 grams, Fructus Gardeniae (parched) 11 grams, Fructus Piperis Longi 16 grams, Fructus Toosendan 8 grams, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 8 grams, Endothelium Corneum Gigeriae Galli 16 grams, Caulis Bambusae In Taenia 14 grams, Concha Ostreae 11 grams, Herba Lythri Salicariae 3 grams, Flos Rosae Rugosae 5 grams, Radix Seu Caulis Mucunae Sempervirentis 13 grams, Radix Sanguisorbae 14 grams, Semen Vaccariae 5 grams, Radix Cucurbitae 12 grams, Herba Violae dissectae 3 grams, Folium Et Cacumen Murrayae 1 gram, Rhizoma Acori Graminei 10 grams, Herba Gentianopsis Paludosae 9 grams, 13 grams of Radix Rubiae, Ramulus Cinnamomi 7 grams, 11 grams of Pericarpium Citri Reticulatae Viride, Fructus Crataegi 3 grams, Semen Coicis 1 gram, 10 grams of Radix Glycyrrhizae, Semen Cassiae 4 grams, Herba Taraxaci 11 grams, Herba Hedyotidis Diffusae 4 grams, Semen Plantaginis 14 grams, Ramulus Salicis Babylonicae 8 grams, Radix Polygoni Multiflori Preparata 3 grams, Radix Saposhnikoviae 6 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) taking each medical material of components by weight percent in described Chinese medicine composition, first time decocts the water boiling and extraction of 15 times that add medical material gross weight, decocts 1-2 hour: second time adds the water of 8-12 times amount, decocts 1-1.2h, leaches medicinal liquid stand-by；Third time adds the water of 8-12 times amount, decocts 0.8-1.2h, leaches medicinal liquid stand-by；Merging three decocting liquids, filter, collect filtrate, being concentrated into relative density when 50-60 DEG C is the clear paste of 1.10-1.30；

(3) dry extract that step (2) prepares is pulverized, add suitable amount of sucrose, dextrin mixing, with ethanol for wetting agent, granulate, dry, granulate, tabletting, prepare tablet.

Embodiment 5:

A kind of pharmaceutical composition treating chronic cholecystitis of the present invention, take following traditional Chinese medicine raw medicine: Herba Lysimachiae 15 grams, Cortex Magnoliae Officinalis 12 grams, Fructus Lycii 5 grams, Fructus Gardeniae (parched) 9 grams, Fructus Piperis Longi 15 grams, Fructus Toosendan 9 grams, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 7 grams, Endothelium Corneum Gigeriae Galli 19 grams, Caulis Bambusae In Taenia 13 grams, Concha Ostreae 10 grams, Herba Lythri Salicariae 4 grams, Flos Rosae Rugosae 4 grams, Radix Seu Caulis Mucunae Sempervirentis 11 grams, Radix Sanguisorbae 11 grams, Semen Vaccariae 5 grams, Radix Cucurbitae 10 grams, Herba Violae dissectae 5 grams, Folium Et Cacumen Murrayae 3 grams, Rhizoma Acori Graminei 8 grams, Herba Gentianopsis Paludosae 8 grams, 14 grams of Radix Rubiae, Ramulus Cinnamomi 9 grams, 12 grams of Pericarpium Citri Reticulatae Viride, Fructus Crataegi 5 grams, Semen Coicis 3 grams, 8 grams of Radix Glycyrrhizae, Semen Cassiae 6 grams, Herba Taraxaci 9 grams, Herba Hedyotidis Diffusae 5 grams, Semen Plantaginis 12 grams, Ramulus Salicis Babylonicae 7 grams, Radix Polygoni Multiflori Preparata 5 grams, Radix Saposhnikoviae 9 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) taking each medical material of components by weight percent in described Chinese medicine composition, first time decocts the water boiling and extraction of 10-15 times that adds medical material gross weight, decocts 1.5 hours: second time adds the water of 8 times amount, decocts 1-1.2h, leaches medicinal liquid stand-by；Third time adds the water of 8-12 times amount, decocts 0.8-1.2h, leaches medicinal liquid stand-by；Merging three decocting liquids, filter, collect filtrate, being concentrated into relative density when 50-60 DEG C is the clear paste of 1.10-1.30；

(2) clear paste that step (1) prepares is placed to room temperature, add ethanol and make, containing amount of alcohol to percentage by weight 75%, to stand 24-48 hour, take supernatant；Supernatant reclaims ethanol, and being evaporated to relative density when 50-60 DEG C is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently；At 60 DEG C of-80 DEG C of spray drying, obtain dry extract；

(3) to above-mentioned steps (2) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, prepare medicinal liquid agent.

Embodiment 6:

A kind of pharmaceutical composition treating chronic cholecystitis of the present invention, take following traditional Chinese medicine raw medicine: Herba Lysimachiae 19 grams, Cortex Magnoliae Officinalis 14 grams, Fructus Lycii 6 grams, Fructus Gardeniae (parched) 7 grams, Fructus Piperis Longi 14 grams, Fructus Toosendan 9 grams, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 6 grams, Endothelium Corneum Gigeriae Galli 17 grams, Caulis Bambusae In Taenia 13 grams, Concha Ostreae 10 grams, Herba Lythri Salicariae 4 grams, Flos Rosae Rugosae 4 grams, Radix Seu Caulis Mucunae Sempervirentis 11 grams, Radix Sanguisorbae 11 grams, Semen Vaccariae 5 grams, Radix Cucurbitae 10 grams, Herba Violae dissectae 5 grams, Folium Et Cacumen Murrayae 3 grams, Rhizoma Acori Graminei 8 grams, Herba Gentianopsis Paludosae 8 grams, 14 grams of Radix Rubiae, Ramulus Cinnamomi 4 grams, 9 grams of Pericarpium Citri Reticulatae Viride, Fructus Crataegi 5 grams, Semen Coicis 3 grams, 8 grams of Radix Glycyrrhizae, Semen Cassiae 3 grams, Herba Taraxaci 8 grams, Herba Hedyotidis Diffusae 5 grams, Semen Plantaginis 15 grams, Ramulus Salicis Babylonicae 7 grams, Radix Polygoni Multiflori Preparata 2 grams, Radix Saposhnikoviae 4 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) taking each medical material of components by weight percent in described Chinese medicine composition, first time decocts the water boiling and extraction of 10-15 times that adds medical material gross weight, decocts 1.2 hours: second time adds the water of 8-12 times amount, decocts 1-1.2h, leaches medicinal liquid stand-by；Third time adds the water of 8-12 times amount, decocts 0.8-1.2h, leaches medicinal liquid stand-by；Merging three decocting liquids, filter, collect filtrate, being concentrated into relative density when 50-60 DEG C is the clear paste of 1.10-1.30；

Acute toxicity test:

Take mice 60, body weight 22-25 gram, be randomly divided into 2 groups by body weight, treatment group and matched group: treatment group takes the medicinal liquid agent of the embodiment of the present invention 6 preparation, and 0.40ml/10g body weight gastric infusion, dose 0.38g/ml are pressed in fasting after 12 hours, matched group takes distilled water, three times on the one, to observation post administration 14 days, none was dead for mice, main organs no abnormality seen, also have no other substantially abnormal, within the 14th day, put to death and cut open inspection some animals, perusal main organs no abnormality seen.

Six months long term toxicity tests: weigh weekly once during administration, claim appetite every day, and without dead or moribund animals, result mice hair color is bright and clean, and behavioral activity, glandular secretion, breathing, feces character are all normal.Pathologic finding is pointed out, to various internal organs without obvious drug-induced pathological change.

Clinical reasoning:

In order to verify the effect of pharmaceutical composition of the present invention, in January, 2013 in JIUYUE ,-2014, chronic cholecystitis patient 200 example is randomly drawed in outpatient service place, random digits table is adopted to be randomly divided into treatment group and matched group, wherein treatment group 100 example, male 49 example, women 51 example, 22～65 years old age；Matched group 100 example, male 50 example, women 50 example, 21～68 years old age.2 groups of sexes, age, courses of disease etc. compare, difference there are no significant meaning (P > 0.05), have comparability.

Diagnostic criteria:

Western medicine diagnose standard: (1) continues upper right abdomen dull pain or sense of discomfort or Ban Youjianjiao district pain.(2) there are the indigestion symptoms such as nauseating, belch, pantothenic acid, abdominal distention and scorching hot, greasy food postemphasis of taking food.(3) course of disease is long, and the course of disease is through having acute attack and alleviating feature alternately.(4) there are mild tenderness or percussion pain in gallbladder area.(5) the visible gallbladder wall of B ultrasonic is crude thickens, or companion's entrant sound is abnormal, and gallbladder reduces or deforms, and maybe can have cholelithiasis.(6) the visible gallbladder of cholecystography reduces or deforms, and gallbladder contraction function is bad, or gallbladder development is thin, or visible cholelithiasis.

All possess (5), one of in (6) two, add the binomial person in the item of (1)-(4), namely diagnosable.

Chinese medical discrimination:

Liver qi stagnation type: pain in the right hypochondrium is based on distending pain, and it is indefinite to walk to alter, and pain often increases, sensation of oppression over the chest with shortness of breath, indigestion and loss of appetite lack of appetite because of feelings will, belch frequency is made, yellow fur, stringy and thready pulse.

Qi stagnation blood stasis type: hypochondriac pain, based on twinge, aches localized pain, or pain draws the shoulder back of the body, enters Night Watch very, feels sick, and belch, poor appetite, purplish tongue is dark, deep and hesitant pulse.

Liver gallbladder damp-heat type: the pain over the hypochondriac region, feeling of fullness, bitter taste, nausea and vomiting, asthenia, conjunctival congestion yellowish body, dark coloured urine dry stool, yellowish fur, wiry and frequent pulse.

Deficiecny of liver-YIN type: epigastrium dull pain, abdominal distention, indigestion and loss of appetite, shallow complexion, singultus, bitter taste, in the heart dysphoria with smothery sensation, have a dizzy spell, red tongue, few tongue, thready,weak and rapid pulse.

Exclusion standard:

(1) acute simplex cholecystitis, acute suppuration cholecystitis, acute gangrenous cholecystitis, acute obstructive suppurative cholecystitis, the concurrent general peritonitis person of perforation of gallbladder are turned out to be on inspection.

(2) age is at under-18s or over-65s；Gestation or women breast-feeding their children, allergic constitution or to this ingredient allergy sufferers.

(3) merge intentionally, cerebrovascular, liver, the serious disease such as kidney and hemopoietic system, psychotic.

Reject, come off and terminate experimental standard:

(1) find not meet the case of inclusive criteria after including in, rejecting need to be given.

(2) experimenter's compliance is poor, and serious adverse events occurs, and occurs complication or special physiological change should not continue to accept experiment, is accordingly to be regarded as the case that comes off.

Therapeutic Method:

Treatment group (of the present invention group) takes the granule of embodiment 1 preparation, and a 10mg is administered orally, three times on the one.

Matched group with XIAOYAN LIDAN PIAN (Boluo County, Guangdong Province with INAA pioneer Pharmaceutical Group Co., Ltd produces, lot number: 050820), three times on the one, one time 4, oral.Two groups all with two weeks for 1 course for the treatment of, therapeutic effect is with clinical symptoms and sign for foundation.

Criterion of therapeutical effect

Basic healing: Clinical symptom and sign disappears substantially, and imaging examination is normal；

Effective: Clinical symptom and sign disappears substantially, imaging examination is obviously improved；

Effective: Clinical symptom and sign partial disappearance, imaging examination has improvement；

Invalid: Clinical symptom and sign and imaging examination are without changing.

Efficacy result:

The group patient's effective percentage relative analysis of 1 liang of table

Group	Case	Basic healing	Effective	Effectively	Invalid	Total effective rate
							Matched group	100	25	29	11	35	65%
Treatment group	100	76	13	7	4	96%

Table 1 result shows: through statistical analysis, between two groups, total effective rate has the difference P < 0.05 of significance after statistical procedures.Illustrate that treatment group curative effect is substantially better than matched group.

Result shows: Chinese medicine composition provided by the invention is determined curative effect in treatment chronic cholecystitis, and is better than prior art.

Model case:

Case 1

Zhao, female, 51 years old, be Qingdao City Laoshan District people, goes to a doctor on March 16th, 2014.More than main suit's right Upper abdominal pain half a year, recently because, after drinking, the pain increased, and infrascapular region radiation to the right, big dry stool, Administration of roxithromycin and XIAOYAN LIDAN PIAN are invalid voluntarily for they.Look into: Fei Shi does not levy the positive, body temperature 38.1 DEG C.Yellowish fur, the matter green grass or young crops stasis of blood, stringy and rolling pulse.B ultrasonic shows, gollbladder dilation is 4.3～8.7cm about, and wall is crude.The capsule giving the embodiment of the present invention 3 is treated, and twice daily, each two, 10 days courses for the treatment of, after the course for the treatment of, all transference cures, body temperature is normal, and upper right abdomen mild tenderness adds again a course for the treatment of, and all diseases disappear, and do not reaccess so far.

Case 2

Money, female, 55 years old, Qingdao Jimo people, went to a doctor on May 1st, 2014.Chronic cholecystitis 5 years.Right rib distension time medical, dull uncomfortable, upper abdomen tenderness, there are dull pain, belch, poor appetite, yellow fur thickness is greasy, dimly red tongue, stringy pulse.Gallbladder x-ray contrast examination is reported as " chronic cholecystitis ", ultrasound diagnosis, and cyst wall thickens, and volume increases, and gallbladder wall is rough and coarse.The medicine decoction giving the embodiment of the present invention 5 is treated, and twice daily, 10 days courses for the treatment of, after 2 courses for the treatment of, symptom substantially alleviates, and checks through B ultrasonic, and gallbladder is clear-cut, smooth, and size and form is normal, continue to take 2 courses for the treatment of, recovery from illness, follow up a case by regular visits to after half a year without recurrence.

Case 3

Grandson, female, 49 years old, people from Shinan District, Qingdao City, went to a doctor on November 23rd, 2013.More than right Upper abdominal pain distension April, because causing upper right abdomen ache after flu, anger, accompany right shoulder back distending pain, tending to vomit of feeling sick, bitter taste poor appetite, suffer from abdominal pain after entering greasy food and increase the weight of.Red tongue, yellow and thin fur, deep and stringy pulse, ultrasound diagnosis: gallbladder 7.0cm × 3.9cm, wall thickness 0.5cm, obscuring in capsule, the powder giving the embodiment of the present invention 2 is treated, twice daily, each two bags, 10 days courses for the treatment of, after 2 courses for the treatment of, symptom is clearly better, and continues to take 3 courses for the treatment of, checks through B ultrasonic, gallbladder is clear-cut, smooth, size and form is normal, recovery from illness, follows up a case by regular visits to without recurrence after 1 year.

Last it is noted that above example is only in order to illustrate technical scheme, it is not intended to limit；Although the present invention being described in detail with reference to previous embodiment, it will be understood by those within the art that: the technical scheme described in foregoing embodiments still can be modified by it, or wherein portion of techniques feature is carried out equivalent replacement；And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.

Claims

1. the pharmaceutical composition treating chronic cholecystitis, it is characterised in that: the crude drug of described pharmaceutical composition is made up of Herba Lysimachiae, Cortex Magnoliae Officinalis, Fructus Gardeniae (parched), Fructus Toosendan, Fructus Piperis Longi, Flos Rosae Rugosae, Endothelium Corneum Gigeriae Galli, Caulis Bambusae In Taenia, Herba Gentianopsis Paludosae, Concha Ostreae, Herba Lythri Salicariae, Radix Seu Caulis Mucunae Sempervirentis, Radix Sanguisorbae, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), Radix Cucurbitae, Semen Coicis, Herba Violae dissectae, Folium Et Cacumen Murrayae, Fructus Lycii, Semen Cassiae, Semen Vaccariae, Rhizoma Acori Graminei, Radix Rubiae, Ramulus Cinnamomi, Pericarpium Citri Reticulatae Viride, Fructus Crataegi, Radix Glycyrrhizae, Herba Taraxaci, Herba Hedyotidis Diffusae, Semen Plantaginis, Ramulus Salicis Babylonicae, Radix Polygoni Multiflori Preparata, Radix Saposhnikoviae.

null2. the pharmaceutical composition for the treatment of chronic cholecystitis according to claim 1，It is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: Herba Lysimachiae 12-20 part，Cortex Magnoliae Officinalis 10-16 part，Fructus Lycii 3-8 part，Fructus Gardeniae (parched) 5-12 part，Fructus Piperis Longi 12-17 part，Fructus Toosendan 7-12 part，Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 4-9 part，Endothelium Corneum Gigeriae Galli 15-20 part，Caulis Bambusae In Taenia 10-15 part，Concha Ostreae 8-12 part，Herba Lythri Salicariae 2-5 part，Flos Rosae Rugosae 3-7 part，Radix Seu Caulis Mucunae Sempervirentis 11-14 part，Radix Sanguisorbae 9-15 part，Semen Vaccariae 3-6 part，Radix Cucurbitae 8-13 part，Herba Violae dissectae 3-5 part，Folium Et Cacumen Murrayae 1-3 part，Rhizoma Acori Graminei 5-10 part，Herba Gentianopsis Paludosae 5-10 part，Radix Rubiae 13-16 part，Ramulus Cinnamomi 3-10 part，Pericarpium Citri Reticulatae Viride 8-13 part，Fructus Crataegi 3-5 part，Semen Coicis 1-3 part，Radix Glycyrrhizae 5-10 part，Semen Cassiae 3-6 part，Herba Taraxaci 8-13 part，Herba Hedyotidis Diffusae 3-5 part，Semen Plantaginis 11-15 part，Ramulus Salicis Babylonicae 5-10 part，Radix Polygoni Multiflori Preparata 2-5 part，Radix Saposhnikoviae 4-9 part.

3. the pharmaceutical composition for the treatment of chronic cholecystitis according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: Herba Lysimachiae 12 parts, Cortex Magnoliae Officinalis 16 parts, Fructus Lycii 3 parts, Fructus Gardeniae (parched) 12 parts, Fructus Piperis Longi 12 parts, Fructus Toosendan 10 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 9 parts, Endothelium Corneum Gigeriae Galli 15 parts, Caulis Bambusae In Taenia 15 parts, Concha Ostreae 8 parts, Herba Lythri Salicariae 5 parts, Flos Rosae Rugosae 3 parts, Radix Seu Caulis Mucunae Sempervirentis 14 parts, Radix Sanguisorbae 9 parts, Semen Vaccariae 6 parts, Radix Cucurbitae 8 parts, Herba Violae dissectae 5 parts, Folium Et Cacumen Murrayae 1 part, Rhizoma Acori Graminei 10 parts, Herba Gentianopsis Paludosae 5 parts, 16 parts of Radix Rubiae, Ramulus Cinnamomi 10 parts, 8 parts of Pericarpium Citri Reticulatae Viride, Fructus Crataegi 5 parts, Semen Coicis 1 part, 10 parts of Radix Glycyrrhizae, Semen Cassiae 6 parts, Herba Taraxaci 8 parts, Herba Hedyotidis Diffusae 3 parts, Semen Plantaginis 15 parts, Ramulus Salicis Babylonicae 5 parts, Radix Polygoni Multiflori Preparata 3 parts, Radix Saposhnikoviae 5 parts.

4. the pharmaceutical composition for the treatment of chronic cholecystitis according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: Herba Lysimachiae 20 parts, Cortex Magnoliae Officinalis 10 parts, Fructus Lycii 8 parts, Fructus Gardeniae (parched) 5 parts, Fructus Piperis Longi 17 parts, Fructus Toosendan 12 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 4 parts, Endothelium Corneum Gigeriae Galli 20 parts, Caulis Bambusae In Taenia 10 parts, Concha Ostreae 12 parts, Herba Lythri Salicariae 2 parts, Flos Rosae Rugosae 7 parts, Radix Seu Caulis Mucunae Sempervirentis 11 parts, Radix Sanguisorbae 15 parts, Semen Vaccariae 3 parts, Radix Cucurbitae 13 parts, Herba Violae dissectae 3 parts, Folium Et Cacumen Murrayae 3 parts, Rhizoma Acori Graminei 5 parts, Herba Gentianopsis Paludosae 10 parts, 13 parts of Radix Rubiae, Ramulus Cinnamomi 3 parts, 13 parts of Pericarpium Citri Reticulatae Viride, Fructus Crataegi 3 parts, Semen Coicis 3 parts, 5 parts of Radix Glycyrrhizae, Semen Cassiae 4 parts, Herba Taraxaci 10 parts, Herba Hedyotidis Diffusae 4 parts, Semen Plantaginis 13 parts, Ramulus Salicis Babylonicae 6 parts, Radix Polygoni Multiflori Preparata 4 parts, Radix Saposhnikoviae 8 parts.

5. the pharmaceutical composition for the treatment of chronic cholecystitis according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: Herba Lysimachiae 13 parts, Cortex Magnoliae Officinalis 11 parts, Fructus Lycii 4 parts, Fructus Gardeniae (parched) 6 parts, Fructus Piperis Longi 13 parts, Fructus Toosendan 7 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 5 parts, Endothelium Corneum Gigeriae Galli 18 parts, Caulis Bambusae In Taenia 11 parts, Concha Ostreae 9 parts, Herba Lythri Salicariae 4 parts, Flos Rosae Rugosae 6 parts, Radix Seu Caulis Mucunae Sempervirentis 12 parts, Radix Sanguisorbae 13 parts, Semen Vaccariae 4 parts, Radix Cucurbitae 9 parts, Herba Violae dissectae 4 parts, Folium Et Cacumen Murrayae 2 parts, Rhizoma Acori Graminei 6 parts, Herba Gentianopsis Paludosae 6 parts, 14 parts of Radix Rubiae, Ramulus Cinnamomi 5 parts, 10 parts of Pericarpium Citri Reticulatae Viride, Fructus Crataegi 4 parts, Semen Coicis 2 parts, 6 parts of Radix Glycyrrhizae, Semen Cassiae 5 parts, Herba Taraxaci 12 parts, Herba Hedyotidis Diffusae 3 parts, Semen Plantaginis 12 parts, Ramulus Salicis Babylonicae 9 parts, Radix Polygoni Multiflori Preparata 4 parts, Radix Saposhnikoviae 7 parts.

6. the pharmaceutical composition for the treatment of chronic cholecystitis according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: Herba Lysimachiae 17 parts, Cortex Magnoliae Officinalis 15 parts, Fructus Lycii 7 parts, Fructus Gardeniae (parched) 11 parts, Fructus Piperis Longi 16 parts, Fructus Toosendan 8 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 8 parts, Endothelium Corneum Gigeriae Galli 16 parts, Caulis Bambusae In Taenia 14 parts, Concha Ostreae 11 parts, Herba Lythri Salicariae 3 parts, Flos Rosae Rugosae 5 parts, Radix Seu Caulis Mucunae Sempervirentis 13 parts, Radix Sanguisorbae 14 parts, Semen Vaccariae 5 parts, Radix Cucurbitae 12 parts, Herba Violae dissectae 3 parts, Folium Et Cacumen Murrayae 1 part, Rhizoma Acori Graminei 10 parts, Herba Gentianopsis Paludosae 9 parts, 13 parts of Radix Rubiae, Ramulus Cinnamomi 7 parts, 11 parts of Pericarpium Citri Reticulatae Viride, Fructus Crataegi 3 parts, Semen Coicis 1 part, 10 parts of Radix Glycyrrhizae, Semen Cassiae 4 parts, Herba Taraxaci 11 parts, Herba Hedyotidis Diffusae 4 parts, Semen Plantaginis 14 parts, Ramulus Salicis Babylonicae 8 parts, Radix Polygoni Multiflori Preparata 3 parts, Radix Saposhnikoviae 6 parts.

7. the pharmaceutical composition for the treatment of chronic cholecystitis according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: Herba Lysimachiae 15 parts, Cortex Magnoliae Officinalis 12 parts, Fructus Lycii 5 parts, Fructus Gardeniae (parched) 9 parts, Fructus Piperis Longi 15 parts, Fructus Toosendan 9 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 7 parts, Endothelium Corneum Gigeriae Galli 19 parts, Caulis Bambusae In Taenia 13 parts, Concha Ostreae 10 parts, Herba Lythri Salicariae 4 parts, Flos Rosae Rugosae 4 parts, Radix Seu Caulis Mucunae Sempervirentis 11 parts, Radix Sanguisorbae 11 parts, Semen Vaccariae 5 parts, Radix Cucurbitae 10 parts, Herba Violae dissectae 5 parts, Folium Et Cacumen Murrayae 3 parts, Rhizoma Acori Graminei 8 parts, Herba Gentianopsis Paludosae 8 parts, 14 parts of Radix Rubiae, Ramulus Cinnamomi 9 parts, 12 parts of Pericarpium Citri Reticulatae Viride, Fructus Crataegi 5 parts, Semen Coicis 3 parts, 8 parts of Radix Glycyrrhizae, Semen Cassiae 6 parts, Herba Taraxaci 9 parts, Herba Hedyotidis Diffusae 5 parts, Semen Plantaginis 12 parts, Ramulus Salicis Babylonicae 7 parts, Radix Polygoni Multiflori Preparata 5 parts, Radix Saposhnikoviae 9 parts.

8. the pharmaceutical composition for the treatment of chronic cholecystitis according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: Herba Lysimachiae 19 parts, Cortex Magnoliae Officinalis 14 parts, Fructus Lycii 6 parts, Fructus Gardeniae (parched) 7 parts, Fructus Piperis Longi 14 parts, Fructus Toosendan 9 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 6 parts, Endothelium Corneum Gigeriae Galli 17 parts, Caulis Bambusae In Taenia 13 parts, Concha Ostreae 10 parts, Herba Lythri Salicariae 4 parts, Flos Rosae Rugosae 4 parts, Radix Seu Caulis Mucunae Sempervirentis 11 parts, Radix Sanguisorbae 11 parts, Semen Vaccariae 5 parts, Radix Cucurbitae 10 parts, Herba Violae dissectae 5 parts, Folium Et Cacumen Murrayae 3 parts, Rhizoma Acori Graminei 8 parts, Herba Gentianopsis Paludosae 8 parts, 14 parts of Radix Rubiae, Ramulus Cinnamomi 4 parts, 9 parts of Pericarpium Citri Reticulatae Viride, Fructus Crataegi 5 parts, Semen Coicis 3 parts, 8 parts of Radix Glycyrrhizae, Semen Cassiae 3 parts, Herba Taraxaci 8 parts, Herba Hedyotidis Diffusae 5 parts, Semen Plantaginis 15 parts, Ramulus Salicis Babylonicae 7 parts, Radix Polygoni Multiflori Preparata 2 parts, Radix Saposhnikoviae 4 parts.

9. the preparation method of the pharmaceutical composition of the arbitrary described treatment chronic cholecystitis of claim 3-8, it is characterised in that described preparation method comprises the steps of:

(1) each medical material of components by weight percent in the arbitrary described pharmaceutical composition of claim 3-8 is taken, first time decocts the water boiling and extraction of 10-15 times that adds medical material gross weight, decoct 1-2 hour: second time adds the water of 8-12 times amount, decoct 1-1.2h, leach medicinal liquid stand-by；Third time adds the water of 8-12 times amount, decocts 0.8-1.2h, leaches medicinal liquid stand-by；Merging three decocting liquids, filter, collect filtrate, being concentrated into relative density when 50-60 DEG C is the clear paste of 1.10-1.30；

10. the application in treatment chronic cholecystitis medicine of the pharmaceutical composition of the treatment chronic cholecystitis as described in as arbitrary in claim 1-8.