CN105213885A - A kind of pharmaceutical composition and application thereof for the treatment of acute pancreatitis - Google Patents

Abstract

Treat a pharmaceutical composition for acute pancreatitis, the crude drug of described pharmaceutical composition is made up of Fructus Aurantii, the Rhizoma Pinelliae, bitter stone company, Herba seu Radix Calanthes, Radix Salviae Miltiorrhizae, Herba Sarcandrae, Rhizoma Corydalis, Radix Gentianae, Rhizoma Imperatae, Periostracum Cicadae, Rhizoma Fagopyri Dibotryis, Herba Pyrolae, Herba Houttuyniae, Endothelium Corneum Gigeriae Galli, Herba Taraxaci, Herba Artemisiae Scopariae, Rhizoma Chuanxiong, Fructus Crataegi, Flos Carthami, Herba Lysimachiae, Rhizoma Paridis, Semen Coicis, Fructus Gardeniae, Folium Ginkgo, Cortex Sclerotii Poriae, Flos Inulae, wild linum, Rhizoma Gastrodiae.This pharmaceutical composition compatibility meets Chinese medicine " monarch " principle, gives prominence to the key points, comprehensive and reasonable, has the advantages that determined curative effect, toxic and side effects are little, easy to use, cheap.

Description

A kind of pharmaceutical composition and application thereof for the treatment of acute pancreatitis

Technical field

The invention belongs to medical art, relate to a kind of Chinese medicine composition, be specifically related to a kind of pharmaceutical composition and application thereof for the treatment of acute pancreatitis.

Background technology

Pancreatitis is the disease that pancreas causes because of tryptic autodigestion effect.Pancreas has edema, hyperemia, or hemorrhage, downright bad, occurs the symptom such as stomachache, abdominal distention, Nausea and vomiting, heating clinically, blood test and amylase content rising in urine etc.

Under normal circumstances, the pancreatin of pancreatic juice containing non-activity in its gland tissue is former.Pancreatic juice constantly flows into duodenum through common bile duct Oddi's sphincter along pancreas pipeline, exist owing to there being bile in duodenum, add that duodenal wall mucosa secretes a kind of enterokinase, under the effect of the two, the former beginning of pancreatin is transformed into active very strong digestive enzyme, if efferent tract is obstructed, drainage difficulty, can cause pancreatitis.When Oddi's sphincter spasm or gallbladder overpressure raise, as calculus, carcinomatous obstruction, bile reflux can enter ductus pancreaticus and enters pancreatic tissue, now, lecithin contained in bile is decomposed into LYSOLECITHIN SUNLECITHIN A by A lecithinase contained in pancreatic juice, toxic action can be produced to pancreas, or during biliary tract infection, antibacterial can discharge kinases and be activated by pancreatin, become the active substance that can damage and dissolve pancreatic tissue equally, these materials change into trypsin by former for pancreatin contained in pancreatic juice, this enzymic digestion is active strong, infiltrate through pancreatic tissue and cause autodigestion, also pancreatitis can be caused.

Pancreatitic main manifestations comprise following some:

(1) suffer a shock: patient often occurs that shock symptom is as pale, cold sweat, thready pulse, blood pressure drops etc., causes the reason of shock to have multiple, as due to pancreatic juice excessive, stimulate peritoneum to cause and have an intense pain; Pancreatic tissue and intraperitoneal hemorrhage; Tissue necrosis, the body that breaks down proteins causes is poisoning.Shock severe patient rescues not in time can be lethal.

(2) suffer from abdominal pain: stomachache is often arranged in epigastrium, be that band shape radiates to lower back sometimes, to bend over or the seat that leans forward can alleviate; Often break out after heavy drinking or heavy meal, degree varies, the lighter is dull pain, and severe one is many in persistence angor.

(3) Nausea and vomiting: namely most of patients onset vomits gastric content, even vomits bile, tells rear stomachache and does not alleviate.

(4) generate heat: most patients with acute pancreatitis occurs that moderate is generated heat, generally continue 3 ~ 5 days.

(5) Water-Electrolyte and acid base imbalance: patient has dehydration in various degree, can there is metabolic alkalosis in frequent vomiter, severe pancreatitis is often with metabolic acidosis, hypocalcemia, blood glucose rising, hypokalemia, hypomagnesemia.

Pancreatitis is mainly divided into acute pancreatitis and chronic pancreatitis, and have eating and drinking too much at one meal or biliary tract history before acute pancreatitis outbreak, acute pancreatitis can be divided into plain edition and hemorrhagic necrosis type more.Hemorrhagic necrosis type is more rare, but is in a bad way, and mortality rate is high.Acute pancreatitis is the acute chemical inflammation of the digestive enzyme generation autodigestion in pancreas.The digestive enzyme of pancreatic secretion digestible saccharide, protein, fat.Pancreas edema or downright bad hemorrhage during acute pancreatitis, clinical manifestation is the sharply upper abdominal pain broken out, and to back radiation, Nausea and vomiting, fever, blood pressure reduce, and blood, amylase in urine raise as feature.Its morbidity is anxious, progress is fast, the state of an illness is heavy, complication is many, mortality rate is high, can cause the MOFE such as the heart, lung, kidney, brain, as do not given treatment in time, can cause death or leave over multiple complications.

Acute pancreatitis etiology and pathogenesis: due to direct stimulation, eating and drinking without temperance as crapulence, gluttony, drink, surfeit is greasy, cold temperature is uncomfortable, the factors such as malnutrition due to parasitic infestation, make human body dysfunction, pancreas is in disorder, causes QI depression of the liver and gallbladder, damp and hotly hinder in middle Jiao, QI of the spleen and stomach is logical falls mistake department, retention of damp-heat in the interior and falling ill.Symptom: stomachache occurs suddenly, multidigit, in epigastrium side slightly to the left, is often persistence severe pain, and pain can be radiated to back and left shoulder, often with nausea and vomiting, the symptoms such as heating, fear of cold, excessive thirst, hyperhidrosis.Sign: (1) abdominal part: tenderness, muscle tonus, rebound tenderness.(2) tongue fur pulse condition: red tongue, yellowish fur, wiry and frequent pulse.Check: (1) is through cave palpation: under the tsusanli acupoint, there is pressure pain point at three to five cun of places, right side of being everlasting finds.(2) laboratory examination: leukocyte increases, neutrophilic granulocyte is abnormal to be increased.Blood, urine pancreatic amylase increase.

The medicine of doctor trained in Western medicine treatment acute pancreatitis has atropine, pentazocine, antondin, phenobarbital; Serious symptom trouble all adopts dolantin, procaine normal saline.Said medicine is emergent medicine, and cost is high, and has more serious side effect.

Summary of the invention

The present invention is directed to weak point of the prior art, provide a kind of pharmaceutical composition and application thereof for the treatment of acute pancreatitis, this pharmaceutical composition technique is simple, and cost is low, has no side effect, in treatment acute pancreatitis, have significant curative effect.

Above-mentioned purpose of the present invention is realized by following technical proposals:

Treat a pharmaceutical composition for acute pancreatitis, the crude drug of described pharmaceutical composition is made up of Fructus Aurantii, the Rhizoma Pinelliae, bitter stone company, Herba seu Radix Calanthes, Radix Salviae Miltiorrhizae, Herba Sarcandrae, Rhizoma Corydalis, Radix Gentianae, Rhizoma Imperatae, Periostracum Cicadae, Rhizoma Fagopyri Dibotryis, Herba Pyrolae, Herba Houttuyniae, Endothelium Corneum Gigeriae Galli, Herba Taraxaci, Herba Artemisiae Scopariae, Rhizoma Chuanxiong, Fructus Crataegi, Flos Carthami, Herba Lysimachiae, Rhizoma Paridis, Semen Coicis, Fructus Gardeniae, Folium Ginkgo, Cortex Sclerotii Poriae, Flos Inulae, wild linum, Rhizoma Gastrodiae.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Fructus Aurantii 12-20 part, bitter stone connects 10-16 part, Herba seu Radix Calanthes 3-8 part, Radix Salviae Miltiorrhizae 5-12 part, Rhizoma Pinelliae 12-17 part, Rhizoma Corydalis 7-12 part, Flos Carthami 4-9 part, Radix Gentianae 15-20 part, Rhizoma Imperatae 10-15 part, Periostracum Cicadae 8-12 part, Rhizoma Fagopyri Dibotryis 2-5 part, Herba Houttuyniae 3-7 part, Herba Taraxaci 11-14 part, Endothelium Corneum Gigeriae Galli 9-15 part, Herba Artemisiae Scopariae 3-6 part, Rhizoma Chuanxiong 8-13 part, Fructus Gardeniae 3-5 part, Herba Pyrolae 1-3 part, Fructus Crataegi 5-10 part, Flos Inulae 5-10 part, Herba Sarcandrae 13-16 part, Herba Lysimachiae 3-10 part, Rhizoma Paridis 8-13 part, Semen Coicis 3-5 part, Folium Ginkgo 1-3 part, wild linum 5-10 part, Cortex Sclerotii Poriae 3-6 part, Rhizoma Gastrodiae 3-5 part.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Fructus Aurantii 12 parts, bitter stone connects 16 parts, Herba seu Radix Calanthes 3 parts, Radix Salviae Miltiorrhizae 12 parts, the Rhizoma Pinelliae 12 parts, Rhizoma Corydalis 10 parts, 9 parts, Flos Carthami, Radix Gentianae 15 parts, Rhizoma Imperatae 15 parts, Periostracum Cicadae 8 parts, Rhizoma Fagopyri Dibotryis 5 parts, Herba Houttuyniae 3 parts, Herba Taraxaci 14 parts, Endothelium Corneum Gigeriae Galli 9 parts, Herba Artemisiae Scopariae 6 parts, Rhizoma Chuanxiong 8 parts, Fructus Gardeniae 5 parts, Herba Pyrolae 1 part, Fructus Crataegi 10 parts, Flos Inulae 5 parts, Herba Sarcandrae 16 parts, Herba Lysimachiae 10 parts, Rhizoma Paridis 8 parts, Semen Coicis 5 parts, Folium Ginkgo 1 part, wild linum 10 parts, Cortex Sclerotii Poriae 6 parts, 3 parts, Rhizoma Gastrodiae.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Fructus Aurantii 20 parts, bitter stone connects 10 parts, Herba seu Radix Calanthes 8 parts, Radix Salviae Miltiorrhizae 5 parts, the Rhizoma Pinelliae 17 parts, Rhizoma Corydalis 12 parts, 4 parts, Flos Carthami, Radix Gentianae 20 parts, Rhizoma Imperatae 10 parts, Periostracum Cicadae 12 parts, Rhizoma Fagopyri Dibotryis 2 parts, Herba Houttuyniae 7 parts, Herba Taraxaci 11 parts, Endothelium Corneum Gigeriae Galli 15 parts, Herba Artemisiae Scopariae 3 parts, Rhizoma Chuanxiong 13 parts, Fructus Gardeniae 3 parts, Herba Pyrolae 3 parts, Fructus Crataegi 5 parts, Flos Inulae 10 parts, Herba Sarcandrae 13 parts, Herba Lysimachiae 3 parts, Rhizoma Paridis 13 parts, Semen Coicis 3 parts, Folium Ginkgo 3 parts, wild linum 5 parts, Cortex Sclerotii Poriae 4 parts, 4 parts, Rhizoma Gastrodiae.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Fructus Aurantii 13 parts, bitter stone connects 11 parts, Herba seu Radix Calanthes 4 parts, Radix Salviae Miltiorrhizae 6 parts, the Rhizoma Pinelliae 13 parts, Rhizoma Corydalis 7 parts, 5 parts, Flos Carthami, Radix Gentianae 18 parts, Rhizoma Imperatae 11 parts, Periostracum Cicadae 9 parts, Rhizoma Fagopyri Dibotryis 4 parts, Herba Houttuyniae 6 parts, Herba Taraxaci 12 parts, Endothelium Corneum Gigeriae Galli 13 parts, Herba Artemisiae Scopariae 4 parts, Rhizoma Chuanxiong 9 parts, Fructus Gardeniae 4 parts, Herba Pyrolae 2 parts, Fructus Crataegi 6 parts, Flos Inulae 6 parts, Herba Sarcandrae 14 parts, Herba Lysimachiae 5 parts, Rhizoma Paridis 10 parts, Semen Coicis 4 parts, Folium Ginkgo 2 parts, wild linum 6 parts, Cortex Sclerotii Poriae 5 parts, 3 parts, Rhizoma Gastrodiae.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Fructus Aurantii 17 parts, bitter stone connects 15 parts, Herba seu Radix Calanthes 7 parts, Radix Salviae Miltiorrhizae 11 parts, the Rhizoma Pinelliae 16 parts, Rhizoma Corydalis 8 parts, 8 parts, Flos Carthami, Radix Gentianae 16 parts, Rhizoma Imperatae 14 parts, Periostracum Cicadae 11 parts, Rhizoma Fagopyri Dibotryis 3 parts, Herba Houttuyniae 5 parts, Herba Taraxaci 13 parts, Endothelium Corneum Gigeriae Galli 14 parts, Herba Artemisiae Scopariae 5 parts, Rhizoma Chuanxiong 12 parts, Fructus Gardeniae 3 parts, Herba Pyrolae 1 part, Fructus Crataegi 10 parts, Flos Inulae 9 parts, Herba Sarcandrae 13 parts, Herba Lysimachiae 7 parts, Rhizoma Paridis 11 parts, Semen Coicis 3 parts, Folium Ginkgo 1 part, wild linum 10 parts, Cortex Sclerotii Poriae 4 parts, 4 parts, Rhizoma Gastrodiae.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Fructus Aurantii 15 parts, bitter stone connects 12 parts, Herba seu Radix Calanthes 5 parts, Radix Salviae Miltiorrhizae 9 parts, the Rhizoma Pinelliae 15 parts, Rhizoma Corydalis 9 parts, 7 parts, Flos Carthami, Radix Gentianae 19 parts, Rhizoma Imperatae 13 parts, Periostracum Cicadae 10 parts, Rhizoma Fagopyri Dibotryis 4 parts, Herba Houttuyniae 4 parts, Herba Taraxaci 11 parts, Endothelium Corneum Gigeriae Galli 11 parts, Herba Artemisiae Scopariae 5 parts, Rhizoma Chuanxiong 10 parts, Fructus Gardeniae 5 parts, Herba Pyrolae 3 parts, Fructus Crataegi 8 parts, Flos Inulae 8 parts, Herba Sarcandrae 14 parts, Herba Lysimachiae 9 parts, Rhizoma Paridis 12 parts, Semen Coicis 5 parts, Folium Ginkgo 3 parts, wild linum 8 parts, Cortex Sclerotii Poriae 6 parts, 5 parts, Rhizoma Gastrodiae.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Fructus Aurantii 19 parts, bitter stone connects 14 parts, Herba seu Radix Calanthes 6 parts, Radix Salviae Miltiorrhizae 7 parts, the Rhizoma Pinelliae 14 parts, Rhizoma Corydalis 9 parts, 6 parts, Flos Carthami, Radix Gentianae 17 parts, Rhizoma Imperatae 13 parts, Periostracum Cicadae 10 parts, Rhizoma Fagopyri Dibotryis 4 parts, Herba Houttuyniae 4 parts, Herba Taraxaci 11 parts, Endothelium Corneum Gigeriae Galli 11 parts, Herba Artemisiae Scopariae 5 parts, Rhizoma Chuanxiong 10 parts, Fructus Gardeniae 5 parts, Herba Pyrolae 3 parts, Fructus Crataegi 8 parts, Flos Inulae 8 parts, Herba Sarcandrae 14 parts, Herba Lysimachiae 4 parts, Rhizoma Paridis 9 parts, Semen Coicis 5 parts, Folium Ginkgo 3 parts, wild linum 8 parts, Cortex Sclerotii Poriae 3 parts, 5 parts, Rhizoma Gastrodiae.

Further, described Chinese medicine composition is prepared according to following method:

(1) get each medical material of components by weight percent in arbitrary described pharmaceutical composition, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1-2 hour: second time adds the water of 8-12 times amount, decocts 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10-1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) pulverized by dry extract obtained for step (2), add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule; Or the dry extract that step (2) is obtained dry, pulverize, and makes powder; Or dry extract obtained for step (2) is pulverized, adds appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or dry extract obtained for step (2) is pulverized, adds suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet; Or to above-mentioned steps (2) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

The invention still further relates to the application of a kind of described pharmaceutical composition in treatment acute pancreatitis medicine.

The pharmaceutical composition for the treatment of acute pancreatitis provided by the present invention, it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:

Fructus Aurantii nature and flavor are bitter, acid, be slightly cold, and return lung, spleen, liver, stomach, large intestine channel, and function to cure mainly after septum pectorale feeling of fullness, distending pain over the hypochondrium, accumulation of food in the stomach and intes tine due to indigestion, distension and fullness in the abdomen, dysentery the diseases such as weight, proctoptosis, uterine prolapse.

The Rhizoma Pinelliae: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.

Bitter stone connects, bitter, cold.Enter the heart, spleen, kidney three warp.Function cures mainly: dissipating blood stasis, pain relieving, and heat clearing away is dried.Control hiccup, dysentery, stranguria with turbid discharge, hematuria, traumatic injury.

Herba seu Radix Calanthes, pungent, micro-hardship, is slightly cold, and enters liver, spleen channel.Function cures mainly: heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain.Main scrofula infections; Carbuncle; Laryngopharynx swelling and pain; Hemorrhoid; Rheumatic arthralgia; Traumatic injury.

Radix Salviae Miltiorrhizae, bitter, be slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

Herba Sarcandrae: be the Herb of golden chestnut orchid Herba Pileae Scriptae Sarcandraglabra (Thunb.) Nakai, nature and flavor slightly warm in nature, bitter in the mouth, pungent.Function cures mainly: anti-inflammation, dispelling wind and removing obstruction in the collateral, blood circulation promoting and dispersing pathogen accumulation.For pneumonia, appendicitis, cellulitis, rheumatic arthralgia, injury from falling down, tumor.

Rhizoma Corydalis, bitter in the mouth, pungent, warm in nature; Return liver, the heart, stomach warp; Benefaction is wandered away, and can rise and can fall, have promoting blood circulation to remove blood stasis, effect of promoting the circulation of QI to relieve pain.Cure mainly obstruction of qi in the chest and cardialgia, the side of body rib, all pains of gastral cavity abdomen, headache, lumbago, colicky, bones and muscles pain, dysmenorrhea, amenorrhea, puerperal, the stasis of blood was suffered from abdominal pain, traumatic injury.

Radix Gentianae, bitter, cold.Return liver, gallbladder meridian.Be used as medicine part for gentianaceae plant Radix Gentianae, Gentiana manshurica, G. triflora and Yunnan Radix Gentianae, root welding technology.Heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.For jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, conjunctival congestion, deaf, hypochondriac pain, bitter taste, convulsion with spasms." detailed outline ": treat throat pain, wind heat night sweat.Fire is posted in liver and gall mutually, have rush down of no help, therefore the gas of the liver benefiting gallbladder of Radix Gentianae, just with its can eliminating pathogen in the liver gallbladder pathogenic heat also.But in large bitter Great Cold, cross clothes and probably to injure one's stomach the gas of middle hair growth promoting, instead help pathogenic fire, also take Rhizoma Coptidis for a long time instead from the justice of cremate." book on Chinese herbal medicine is newly organized ": Radix Gentianae, its merit, specially in diuretic, disappears wet, and except jaundice, all the other are controlled order, dysentery relieving, detumescent, bring down a fever, and the speech of all popularizations also.But this kind too divides profit, rather consume gas deteriorated blood, water goes and blood also goes, wet disappearing and gas also disappears, from the beginning of water to wet jaundice, have to urgently with it, the water of prolonged illness wets jaundice, with must delay, just cannot not entirely rely on for diuretic god red, disappearing the wet miraculous cure removing illness also.Or meaning Radix Gentianae is controlled damp and hot, the most sharp illness is sick, just damp and hot disease also, so with Radix Gentianae with subcutaneous ulcer of harnessing the Yellow River, have not effect person, how also more? the real incessantly damp and hot one of jaundice also, have not hot and also become jaundice person, can control also by non-Radix Gentianae.Outstanding Radix Gentianae rushes down the heat in wetting, and can not rush down not hot wetting also.

Rhizoma Imperatae, sweet, cold.Return lung, stomach, urinary bladder channel.Function cures mainly: cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema.

Periostracum Cicadae, sweet, cold.Return lung, stomach, urinary bladder channel.Function cures mainly: cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema.

Rhizoma Fagopyri Dibotryis: cool in nature, acrid in the mouth, hardship.Energy heat-clearing and toxic substances removing, eliminating carbuncle of invigorating blood circulation, expelling wind and removing dampness sore, snake bite and insect sting.Main lung abscess, lung-heat cough with asthma, laryngopharynx swelling and pain, dysentery, rheumatism arthromyodynia, traumatic injury, carbuncle cancer.

Herba Pyrolae, sweet, bitter, temperature.Return liver, kidney channel.Function cures mainly: wind-damp dispelling, bone and muscle strengthening, hemostasis.For rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.

Herba Houttuyniae: latin name houttuyniaeherba, acrid in the mouth, cold nature, enters lung, urinary bladder channel, has heat-clearing and toxic substances removing, removing pus and relieving carbuncle, effect of inducing diuresis for treating stranguria syndrome, and for pneumonopathy vomiting pus, expectorant heat syndrome cough is breathed heavily, toxic-heat and blood stasis, damp-heat gonorrhoea, pyretic toxicity carbuncle sore, and snakeworm wants first-class card.

Endothelium Corneum Gigeriae Galli: property is sweet puts down, be slightly cold, nontoxic, returns spleen, stomach, kidney, urinary bladder channel.Cure mainly: can promoting digestion and invigorating the stomach, arresting seminal emission, fossil.Removing food stagnancy is stagnant, strengthening the spleen and stomach.Control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.

Herba Taraxaci: be feverfew Herba Taraxaci TaraxacummongolicumHand.-Mazz., alkali ground Herba Taraxaci TaraxacumsinicumKitag. or the dry herb belonging to several plants together.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.

Herba Artemisiae Scopariae: bitter in the mouth, pungent, cold nature.Return spleen, stomach, liver, gallbladder meridian.Function cures mainly: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus; Infectious jaundice type hepatitis." herbal classic ": the raw pathogenic heat gas of main air, accumulation of heat jaundice." not Lu ": control the whole body jaundice, dysuria, except feverish sensation in the head, removes mass in the large intestine.Supplement to the Herbal: get round by bribery, go stagnant heat, typhoid fever uses it." medical center bun is wanted ": hard kidney, dry spleen wets, and goes strongly fragrant, antipyretic." book on Chinese herbal medicine is new again ": pathogenic fire purging, suppressing the hyperactive liver, reduces phlegm, cough-relieving diaphoresis, dampness removing, detumescence, treats all poison of skin ulcer fire.

Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to latus rectum of invigorating blood circulation, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converge with speech ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or blood is tired of bruise, and coma in silence; Or lochia robs the heart, umbilicus angina abdominis; Or drop slurry is difficult raw; Or afterbirth does not fall, dead fetus in the uterus, be all just before giving birth all cards, non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters blood room, delirium is gone mad; Or blood is vexed interior swollen, sudden syncope with rigidity as extremely, be all puerperal all cards, non-Flos Carthami can not be determined.All as obstructed in amenorrhea and cold and heat are handed over and are done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood are amassed, or skin infection sufferings and swollen burst uneasy, be the card of all disharmony between QI and blood, non-Flos Carthami can not be adjusted, Flos Carthami promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, there are inhibition thrombosis, antiinflammatory, analgesic effect, there is the vasoconstrictive effect eliminating epinephrine, norepinephrine, have " tonneau passages through which vital energy circulates " to act on.

Rhizoma Chuanxiong, pungent, temperature.Enter liver, gallbladder meridian.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." herbal classic " carries it: main apoplexy enters brain headache, arthralgia due to cold, clonic spasm of the muscle emergency, and gold wound, married woman's blood closes loss of fecundity." not Lu " carries it: " except cold dynamic in brain, on face, urticaria goes, order lacrimation, profuse nasal discharge and spittle, before we notice it as liquor-saturated, all cold gas, the hard pain of trusted subordinate, attacked by pestiferous factors, soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold." be the good medicine of regulating qi to disperse stagnation.

Fructus Crataegi: property, tepor.Taste is sweet, sour.Enter spleen, stomach, Liver Channel.This product is apt to promoting QI to circulate and dispersing the agglomeration of the pathogens, the effect of promoting digestion and removing stagnation; Current QI and blood, blood circulation promoting and blood stasis dispelling, treatment hyperlipidemia, hypertension all have good therapeutic effect; Its energy blood fat reducing, atherosclerosis, can reduce serum cholesterol and triglyceride again; Can also coronary artery dilator, increase coronary flow, Ischemic myocardium anoxia, heart tonifying, blood pressure lowering and arrhythmia; Removing Blood Stasis and do not hinder fresh blood, dissipating depression of QI gas and do not hinder healthy energy, the outstanding peace of its property also.

Rhizoma Gastrodiae: property is flat.Taste, sweet.Master enters Liver Channel.This product endogenous wind stopping relieving convulsion, suppressing liver-YANG, dispelling wind and removing obstruction in the collateral.For controlling key medicine that is dizzy, headache; Again in numb limbs and tense tendons, hands and feet caused by paralysis, rheumatic arthralgia, the good merchantable brand of muscles and bones contracture.

Herba Lysimachiae: sweet in the mouth, micro-hardship, cool in nature.Return liver, gallbladder, kidney, urinary bladder channel.Function cures mainly: relieving stranguria by diuresis; Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Cure mainly liver and gall and urinary system calculus; Pyretic stranguria; Oedema due to nephritis; Jaundice due to damp-heat; Sore carbuncle; Venom; Traumatic injury.

Rhizoma Paridis hardship is slightly cold, and returns Liver Channel, function heat-clearing and toxic substances removing, reducing swelling and alleviating pain, and Radix Sophorae Flavescentis is bitter, and cold, GUIXIN, liver, stomach, large intestine, urinary bladder channel, have heat clearing and damp drying, parasite killing, the merit of diuresis.

Semen Coicis: enter spleen, lung, kidney channel.Spleen invigorating, tonifying the lung, heat clearing away, dampness removing.Control and have loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea.

Its cold in nature, bitter in the mouth of Fructus Gardeniae, function with cure mainly: pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, Shennong's Herbal: " cure mainly pathogen in five, tuberculoid leprosy, red leprosy, skin infection ....”

Folium Ginkgo: function cures mainly: relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving, for cough and asthma due to lung deficiency, coronary heart diseases and angina pectoris, hyperlipidemia.

Cortex Sclerotii Poriae: meridian distribution of property and flavor: flat; Sweet, light; GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Flos Inulae, bitter, pungent, salty, tepor.Return lung, spleen, stomach, large intestine channel.Function cures mainly: sending down the abnormal ascending QI, expectorant, row water, preventing or arresting vomiting.For cough due to wind and cold, phlegm retention stores knot, chest and diaphragm feeling of fullness, dyspnea and cough with excessive sputum, vomiting eructation, epigastric oppression and rigidity.

Wild linum is that the wild linum of Scrophulariaceae belongs to perennial vertical herbage, high 15-50 centimetre, without hair or young tender time thin by pubescence.Latin is called DodartiaorientalisL., produces the Inner Mongol, Ningxia, Gansu, Xinjiang, Sichuan, Mongolia, the Soviet Union, Iran.Heat-clearing and toxic substances removing, loose wind is antipruritic.For senile chronic tracheitis, cough phlegm dyspnea, infantile pneumonia, tonsillitis, lymphadenitis, tonsillitis, acute mastitis, conjunctivitis, conjunctival congestion, urinary tract infection, urine leaching pain, suffers from a deficiency of the kidney.Outer for eczema, urticaria, skin pruritus, neurasthenia.The present invention is with all herbal medicine.

Theory of Chinese medical science is thought, acute pancreatitis is the scope of the disease such as " stomachache " in the traditional Chinese medical science, " gastroenteralgia ", " splenic precordial pain ", its cause of disease is the spleen being located in middle-JIAO, cover granary, spleen and stomach are shown to manage mutually, pancreas belongs to spleen, has Tianjin to manage and communicates with gallbladder intestinal, and because feelings will is not private, eating and drinking without temperance, eating cold and uncooked food excessively, greasy delicious food and wine damages its taste.Or because of ascarid harass, gallbladder pancreatolith is long-pending, retardance Tianjin pipe and cause liver spleen and be retarded by silt, lateral road the intestines and stomach.Or because of six evil Sheng wound and spleen and liver and gall, cause spleen and stomach function disorderly, ascending or descending movement of vital Qi mistake department, there is pure and impure lifting obstacle, retention of dampness due to stagnation of QI, the stasis of blood stop up obstructed, stagnated fire heat-transformation, spleen soil burnt by damp and hot fighting mutually and removing dampness fire and fall ill, and scorchingly hot flourishing in internal organs, battalion of caving in defends the deeply worried impairment of ZANG FU-organs filled the air, QI and blood consumption wound, positive exogenous pathogen falls into and then occurs the serious syndromes such as high heat.Visible pancreatitic treatment by heat clearing away eliminating carbuncle, blood circulation promoting and dispersing pathogen accumulation reaches that the clear carbuncle of heat disappears, QI and blood adjust along and pain relief and even elimination.

Meanwhile, " organic conception ", " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", " compound recipe use ", " compound compatibility medication is as used military forces " are the traditional Chinese medical science the most effective most scientific several large advantages, and wherein " compound compatibility medication is as used military forces " is the original theory of Chinese medicine of very science.The tight compatibility that in traditional Chinese medical science prescription, each medicine is all linked with one another as arrayed troops for battle is that it is better than the effective means of Western medicine formula.Tcm prescription theory is thought, each prescription, not only need to select the appropriate compatibility of suitable medicine according to etiology and pathogenesis, also should meet the basic structure of prescription simultaneously, the i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " is exactly that it is based upon the scientific matching on the comprehensive judgement basis of disease pathogenesis.In medical side by too many levels, Mutiple Targets Integrate adjustment biological mechanism, can to obtain than Western medicine more lastingly, the more therapeutic effect that has no side effect of green natural, and this curative effect be based upon the above-mentioned traditional Chinese medical science tradition original theory accurate instruction on, the present invention just have followed this principle.In the present invention, Herba seu Radix Calanthes, Herba Sarcandrae, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Rhizoma Paridis dredging intestines, solution poison addiction, play the effect of monarch drug in the composition; The effect that Rhizoma Chuanxiong, bitter stone company, Radix Salviae Miltiorrhizae, Rhizoma Corydalis, Rhizoma Imperatae, Periostracum Cicadae, Herba Taraxaci, Flos Carthami, Herba Lysimachiae, Cortex Sclerotii Poriae, Radix Gentianae, wild linum assist monarch drug to play catharsis to purge heat, and strengthen the effect of heat-clearing and toxic substances removing and invigorating blood circulation addiction, play the effect of ministerial drug in the composition; Fructus Crataegi, Fructus Aurantii, the Rhizoma Pinelliae, Herba Pyrolae, Endothelium Corneum Gigeriae Galli, Rhizoma Gastrodiae, Folium Ginkgo, the common promoting the circulation of QI to relieve pain of Flos Inulae, play the effect of adjuvant drug, and Herba Artemisiae Scopariae, Semen Coicis, Fructus Gardeniae coordinating the actions of various ingredients in a prescription, play the effect making medicine.Drug component in the present composition, through dialectical compatibility, complements each other using, has synergism, play effect of spleen invigorating lung benefiting, soothing liver-QI for relieving depression, blood circulation promoting and blood stasis dispelling, heat clearing and damp drying altogether, acute pancreatitis is reached to the object for the treatment of both the principal and secondary aspects of a disease.

The pharmaceutical composition compatibility for the treatment of acute pancreatitis of the present invention meets Chinese medicine " monarch " principle, gives prominence to the key points, comprehensive and reasonable, has the advantages that determined curative effect, toxic and side effects are little, easy to use, cheap.

Detailed description of the invention

For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with embodiment, technical scheme of the present invention is clearly and completely described.Obviously, described embodiment is a part of the present invention, instead of whole embodiments.Based on described embodiments of the invention, the every other embodiment that those of ordinary skill in the art obtain under without the need to the prerequisite of creative work, all belongs to the scope of protection of the invention.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.

Embodiment 1:

A kind of pharmaceutical composition for the treatment of acute pancreatitis of the present invention, get following traditional Chinese medicine raw medicine: Fructus Aurantii 12 grams, bitter stone connects 16 grams, Herba seu Radix Calanthes 3 grams, Radix Salviae Miltiorrhizae 12 grams, the Rhizoma Pinelliae 12 grams, Rhizoma Corydalis 10 grams, 9 grams, Flos Carthami, Radix Gentianae 15 grams, Rhizoma Imperatae 15 grams, Periostracum Cicadae 8 grams, Rhizoma Fagopyri Dibotryis 5 grams, Herba Houttuyniae 3 grams, Herba Taraxaci 14 grams, Endothelium Corneum Gigeriae Galli 9 grams, Herba Artemisiae Scopariae 6 grams, Rhizoma Chuanxiong 8 grams, Fructus Gardeniae 5 grams, Herba Pyrolae 1 gram, Fructus Crataegi 10 grams, Flos Inulae 5 grams, Herba Sarcandrae 16 grams, Herba Lysimachiae 10 grams, Rhizoma Paridis 8 grams, Semen Coicis 5 grams, Folium Ginkgo 1 gram, wild linum 10 grams, Cortex Sclerotii Poriae 6 grams, 3 grams, Rhizoma Gastrodiae.

Embodiment 2:

A kind of pharmaceutical composition for the treatment of acute pancreatitis of the present invention, get following traditional Chinese medicine raw medicine: Fructus Aurantii 20 grams, bitter stone connects 10 grams, Herba seu Radix Calanthes 8 grams, Radix Salviae Miltiorrhizae 5 grams, the Rhizoma Pinelliae 17 grams, Rhizoma Corydalis 12 grams, 4 grams, Flos Carthami, Radix Gentianae 20 grams, Rhizoma Imperatae 10 grams, Periostracum Cicadae 12 grams, Rhizoma Fagopyri Dibotryis 2 grams, Herba Houttuyniae 7 grams, Herba Taraxaci 11 grams, Endothelium Corneum Gigeriae Galli 15 grams, Herba Artemisiae Scopariae 3 grams, Rhizoma Chuanxiong 13 grams, Fructus Gardeniae 3 grams, Herba Pyrolae 3 grams, Fructus Crataegi 5 grams, Flos Inulae 10 grams, Herba Sarcandrae 13 grams, Herba Lysimachiae 3 grams, Rhizoma Paridis 13 grams, Semen Coicis 3 grams, Folium Ginkgo 3 grams, wild linum 5 grams, Cortex Sclerotii Poriae 4 grams, 4 grams, Rhizoma Gastrodiae.

Embodiment 3:

A kind of pharmaceutical composition for the treatment of acute pancreatitis of the present invention, get following traditional Chinese medicine raw medicine: Fructus Aurantii 13 grams, bitter stone connects 11 grams, Herba seu Radix Calanthes 4 grams, Radix Salviae Miltiorrhizae 6 grams, the Rhizoma Pinelliae 13 grams, Rhizoma Corydalis 7 grams, 5 grams, Flos Carthami, Radix Gentianae 18 grams, Rhizoma Imperatae 11 grams, Periostracum Cicadae 9 grams, Rhizoma Fagopyri Dibotryis 4 grams, Herba Houttuyniae 6 grams, Herba Taraxaci 12 grams, Endothelium Corneum Gigeriae Galli 13 grams, Herba Artemisiae Scopariae 4 grams, Rhizoma Chuanxiong 9 grams, Fructus Gardeniae 4 grams, Herba Pyrolae 2 grams, Fructus Crataegi 6 grams, Flos Inulae 6 grams, Herba Sarcandrae 14 grams, Herba Lysimachiae 5 grams, Rhizoma Paridis 10 grams, Semen Coicis 4 grams, Folium Ginkgo 2 grams, wild linum 6 grams, Cortex Sclerotii Poriae 5 grams, 3 grams, Rhizoma Gastrodiae.

Embodiment 4:

A kind of pharmaceutical composition for the treatment of acute pancreatitis of the present invention, get following traditional Chinese medicine raw medicine: Fructus Aurantii 17 grams, bitter stone connects 15 grams, Herba seu Radix Calanthes 7 grams, Radix Salviae Miltiorrhizae 11 grams, the Rhizoma Pinelliae 16 grams, Rhizoma Corydalis 8 grams, 8 grams, Flos Carthami, Radix Gentianae 16 grams, Rhizoma Imperatae 14 grams, Periostracum Cicadae 11 grams, Rhizoma Fagopyri Dibotryis 3 grams, Herba Houttuyniae 5 grams, Herba Taraxaci 13 grams, Endothelium Corneum Gigeriae Galli 14 grams, Herba Artemisiae Scopariae 5 grams, Rhizoma Chuanxiong 12 grams, Fructus Gardeniae 3 grams, Herba Pyrolae 1 gram, Fructus Crataegi 10 grams, Flos Inulae 9 grams, Herba Sarcandrae 13 grams, Herba Lysimachiae 7 grams, Rhizoma Paridis 11 grams, Semen Coicis 3 grams, Folium Ginkgo 1 gram, wild linum 10 grams, Cortex Sclerotii Poriae 4 grams, 4 grams, Rhizoma Gastrodiae.

Embodiment 5:

A kind of pharmaceutical composition for the treatment of acute pancreatitis of the present invention, get following traditional Chinese medicine raw medicine: Fructus Aurantii 15 grams, bitter stone connects 12 grams, Herba seu Radix Calanthes 5 grams, Radix Salviae Miltiorrhizae 9 grams, the Rhizoma Pinelliae 15 grams, Rhizoma Corydalis 9 grams, 7 grams, Flos Carthami, Radix Gentianae 19 grams, Rhizoma Imperatae 13 grams, Periostracum Cicadae 10 grams, Rhizoma Fagopyri Dibotryis 4 grams, Herba Houttuyniae 4 grams, Herba Taraxaci 11 grams, Endothelium Corneum Gigeriae Galli 11 grams, Herba Artemisiae Scopariae 5 grams, Rhizoma Chuanxiong 10 grams, Fructus Gardeniae 5 grams, Herba Pyrolae 3 grams, Fructus Crataegi 8 grams, Flos Inulae 8 grams, Herba Sarcandrae 14 grams, Herba Lysimachiae 9 grams, Rhizoma Paridis 12 grams, Semen Coicis 5 grams, Folium Ginkgo 3 grams, wild linum 8 grams, Cortex Sclerotii Poriae 6 grams, 5 grams, Rhizoma Gastrodiae.

Embodiment 6:

A kind of pharmaceutical composition for the treatment of acute pancreatitis of the present invention, get following traditional Chinese medicine raw medicine: Fructus Aurantii 19 grams, bitter stone connects 14 grams, Herba seu Radix Calanthes 6 grams, Radix Salviae Miltiorrhizae 7 grams, the Rhizoma Pinelliae 14 grams, Rhizoma Corydalis 9 grams, 6 grams, Flos Carthami, Radix Gentianae 17 grams, Rhizoma Imperatae 13 grams, Periostracum Cicadae 10 grams, Rhizoma Fagopyri Dibotryis 4 grams, Herba Houttuyniae 4 grams, Herba Taraxaci 11 grams, Endothelium Corneum Gigeriae Galli 11 grams, Herba Artemisiae Scopariae 5 grams, Rhizoma Chuanxiong 10 grams, Fructus Gardeniae 5 grams, Herba Pyrolae 3 grams, Fructus Crataegi 8 grams, Flos Inulae 8 grams, Herba Sarcandrae 14 grams, Herba Lysimachiae 4 grams, Rhizoma Paridis 9 grams, Semen Coicis 5 grams, Folium Ginkgo 3 grams, wild linum 8 grams, Cortex Sclerotii Poriae 3 grams, 5 grams, Rhizoma Gastrodiae.

Wherein, the preparation method of the described Chinese medicine composition of embodiment 1-6 is:

(1) each medical material of components by weight percent in the arbitrary described Chinese medicine composition of Example 1-6, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decoct 1-2 hour: second time adds the water of 8-12 times amount, decoct 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10-1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) pulverized by dry extract obtained for step (2), add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule; Or the dry extract that step (2) is obtained dry, pulverize, and makes powder; Or dry extract obtained for step (2) is pulverized, adds appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or dry extract obtained for step (2) is pulverized, adds suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet; Or to above-mentioned steps (2) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

Acute toxicity test

Method one:

Test material: Kunming mouse 40, body weight 22-25g.Medicine: the medicinal liquid agent that the embodiment of the present invention 1 is obtained, containing 0.0365mg/ml.

Method:

LD50 calculates: adopt improvement karber's method, mice is divided into 4 groups at random, often organize 10, medicinal liquid agent adding distil water obtained for the embodiment of the present invention 3 is dissolved, is made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 18.5,14.8,12.2 to dosage by crude drug amount, 9.6,7.2 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in a day (interval half an hour), each 0.6ml, observes animal dead situation.

Result of the test: in LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, to observation post administration 14 days, none was dead for mice, main organs no abnormality seen, also have no other obviously abnormal, within the 14th day, put to death and cut open inspection some animals, perusal main organs no abnormality seen.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Six months long term toxicity tests: weigh weekly once during administration, every day claims appetite, without dead or moribund animals, result mice hair color is bright and clean, and behavioral activity, glandular secretion, breathing, feces character are all normal.Pathologic finding is pointed out, to various internal organs without obvious drug-induced pathological change.

Clinical reasoning:

In order to verify the effect of pharmaceutical composition of the present invention, in May ,-2014 in October, 2012, patients with acute pancreatitis 180 example is randomly drawed in outpatient service place, random digits table is adopted to be divided into treatment group and matched group at random, wherein treatment group 90 example, male 39 example, women 51 example, 22 ~ 65 years old age; Matched group 90 example, male 40 example, women 50 example, 21 ~ 68 years old age.The shortest person's two weeks of the course of disease, most elder 6 months, 2 groups of sexes, age, courses of disease etc. compare, and difference there are no significant meaning (P>0.05), has comparability.

Diagnostic criteria:

1, lab testing: (1) pancreatin measures: serum amyloid enzyme values obviously raises >500U/dl.Comprise leukocyte to increase, hyperglycemia, abnormal liver function, low blood calcium, blood gas analysis and DIC Indexes Abnormality etc.;

2, irradiation image diagnosis: (1) C-XF: inferior lobe of left lung is not opened, left half diaphram raises, and left side hydrothorax etc. reflect around diaphram and retroperitoneal inflammation.。(2) plain abdominal radiograph: duodenum is inflated, represents the expansion of nearly section jejunum paralysis.Be also shown in colon abrupt sign, represent the expansion of transverse colon paralysis, splenic flexure colon and section colonic far away are without gas shadow.Maybe can see cholelithiasis shadow and pancreatic stones shadow, and the disappearance of psoas major shadow etc.(3) Abdominal B type ultrasonography: can assisted diagnosis.B ultrasonic scanning can find pancreas edema and pancreas week the gathering of liquid.(4) Enhanced CT: the change of pancreas comprises diffusivity or focal pancreas increases.Edema, downright bad liquefaction, pancreas surrounding tissue fogs, and thickens.And visible hydrops.

Treatment

Treatment group patient takes capsule prepared by the embodiment of the present invention 6, twice daily, each two, one after each meal.Matched group octreotide 0.1 ~ 0.3mg adds in 5% Glucose Liquid 500m1 with the speed intravenous drip of 25 ~ 50 μ g/h; Two groups equal seven days is a course for the treatment of.

Curative effect determinate standard

With reference to the curative effect judging standard that " the new Chinese medicine clinical guidance principle " of health ministry issue in 1993 is formulated.

Cure: in 3d, symptom, sign are alleviated, and disappear in 7d, blood, amylase in urine recover normal;

Effective: in 7d, symptom, sign significantly take a turn for the better, blood, amylase in urine recover normal;

Effective: in 7d, symptom, sign alleviate, blood, amylase in urine have downward trend;

Invalid: in 7d, symptom, sign do not alleviate or worsen, and blood, amylase in urine do not reduce.

Result:

Curative effect comparision result after two groups of case treatments is as following table:

Two groups of patient clinical comparitive study (routine %)

Group

Number of cases

Cure

Effective

Effectively

Invalid

Effectively total

Treatment group

90

27(30％)

54(60％)

7(7.8％)

2(2.2％)

87(97.8％)

Matched group

90

4(4.4％)

27(30％)

11(12.2％)

48(53.3％)

42(46.7％)

Two groups of patient clinical comparitive study: treatment group total effective rate is 97.8%, matched group is that 46.7%, two groups of comparing differences have statistical significance (P<0.05).Treatment group is better than matched group.There is not side effect in treatments period treatment group, 4 examples appear in matched group side effect.Visible, the obtained medicine of the preferred embodiment for the present invention can safe and effective treatment acute pancreatitis, and effective percentage is significantly higher than matched group.

Model case:

Case 1

Zhao, female, 51 years old is Qingdao City Laoshan District people, goes to a doctor on March 16th, 2014.Patient happens suddenly stomachache, and with symptoms such as nausea and vomiting, constipation due to dry stool, diagnosis and treatment are acute pancreatitis.The capsule giving the embodiment of the present invention 3 is treated, twice daily, and each two, 10 days courses for the treatment of, after the course for the treatment of, stomachache disappears substantially, without nausea and vomiting phenomenon, start smooth defecation, all return to normally through lab testing blood amylase, amylase in urine and routine blood test.

Case 2

Money, female, 55 years old, Qingdao Jimo people, went to a doctor on May 1st, 2014.Suffer from acute pancreatitis, vomiting, stomachache, scorching hot in the heart, breathe tachypnea, diagnosis and treatment are acute pancreatitis.The granule giving the embodiment of the present invention 6 is treated, twice daily, and each two bags, 10 days courses for the treatment of, after 3 courses for the treatment of, stomachache disappears substantially, without vomiting, stomachache, heating phenomenon in the heart, all returns to normally through lab testing blood amylase, amylase in urine and routine blood test.

Case 3

Grandson, female, 49 years old, people from Shinan District, Qingdao City, went to a doctor on November 23rd, 2013.Suffer from acute pancreatitis, vomiting, stomachache, scorching hot in the heart, breathe tachypnea, diagnosis and treatment are acute pancreatitis.The medicine decoction giving the embodiment of the present invention 1 is treated, and twice daily, 10 days courses for the treatment of, after 2 courses for the treatment of, stomachache disappears substantially, and without vomiting, stomachache, heating phenomenon in the heart, all returns to normally through lab testing blood amylase, amylase in urine and routine blood test.

Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.

Claims (10)

1. treat a pharmaceutical composition for acute pancreatitis, it is characterized in that: the crude drug of described pharmaceutical composition is made up of Fructus Aurantii, the Rhizoma Pinelliae, bitter stone company, Herba seu Radix Calanthes, Radix Salviae Miltiorrhizae, Herba Sarcandrae, Rhizoma Corydalis, Radix Gentianae, Rhizoma Imperatae, Periostracum Cicadae, Rhizoma Fagopyri Dibotryis, Herba Pyrolae, Herba Houttuyniae, Endothelium Corneum Gigeriae Galli, Herba Taraxaci, Herba Artemisiae Scopariae, Rhizoma Chuanxiong, Fructus Crataegi, Flos Carthami, Herba Lysimachiae, Rhizoma Paridis, Semen Coicis, Fructus Gardeniae, Folium Ginkgo, Cortex Sclerotii Poriae, Flos Inulae, wild linum, Rhizoma Gastrodiae.

2. the pharmaceutical composition for the treatment of acute pancreatitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Fructus Aurantii 12-20 part, bitter stone connects 10-16 part, Herba seu Radix Calanthes 3-8 part, Radix Salviae Miltiorrhizae 5-12 part, Rhizoma Pinelliae 12-17 part, Rhizoma Corydalis 7-12 part, Flos Carthami 4-9 part, Radix Gentianae 15-20 part, Rhizoma Imperatae 10-15 part, Periostracum Cicadae 8-12 part, Rhizoma Fagopyri Dibotryis 2-5 part, Herba Houttuyniae 3-7 part, Herba Taraxaci 11-14 part, Endothelium Corneum Gigeriae Galli 9-15 part, Herba Artemisiae Scopariae 3-6 part, Rhizoma Chuanxiong 8-13 part, Fructus Gardeniae 3-5 part, Herba Pyrolae 1-3 part, Fructus Crataegi 5-10 part, Flos Inulae 5-10 part, Herba Sarcandrae 13-16 part, Herba Lysimachiae 3-10 part, Rhizoma Paridis 8-13 part, Semen Coicis 3-5 part, Folium Ginkgo 1-3 part, wild linum 5-10 part, Cortex Sclerotii Poriae 3-6 part, Rhizoma Gastrodiae 3-5 part.

3. the pharmaceutical composition for the treatment of acute pancreatitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Fructus Aurantii 12 parts, bitter stone connects 16 parts, Herba seu Radix Calanthes 3 parts, Radix Salviae Miltiorrhizae 12 parts, the Rhizoma Pinelliae 12 parts, Rhizoma Corydalis 10 parts, 9 parts, Flos Carthami, Radix Gentianae 15 parts, Rhizoma Imperatae 15 parts, Periostracum Cicadae 8 parts, Rhizoma Fagopyri Dibotryis 5 parts, Herba Houttuyniae 3 parts, Herba Taraxaci 14 parts, Endothelium Corneum Gigeriae Galli 9 parts, Herba Artemisiae Scopariae 6 parts, Rhizoma Chuanxiong 8 parts, Fructus Gardeniae 5 parts, Herba Pyrolae 1 part, Fructus Crataegi 10 parts, Flos Inulae 5 parts, Herba Sarcandrae 16 parts, Herba Lysimachiae 10 parts, Rhizoma Paridis 8 parts, Semen Coicis 5 parts, Folium Ginkgo 1 part, wild linum 10 parts, Cortex Sclerotii Poriae 6 parts, 3 parts, Rhizoma Gastrodiae.

4. the pharmaceutical composition for the treatment of acute pancreatitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Fructus Aurantii 20 parts, bitter stone connects 10 parts, Herba seu Radix Calanthes 8 parts, Radix Salviae Miltiorrhizae 5 parts, the Rhizoma Pinelliae 17 parts, Rhizoma Corydalis 12 parts, 4 parts, Flos Carthami, Radix Gentianae 20 parts, Rhizoma Imperatae 10 parts, Periostracum Cicadae 12 parts, Rhizoma Fagopyri Dibotryis 2 parts, Herba Houttuyniae 7 parts, Herba Taraxaci 11 parts, Endothelium Corneum Gigeriae Galli 15 parts, Herba Artemisiae Scopariae 3 parts, Rhizoma Chuanxiong 13 parts, Fructus Gardeniae 3 parts, Herba Pyrolae 3 parts, Fructus Crataegi 5 parts, Flos Inulae 10 parts, Herba Sarcandrae 13 parts, Herba Lysimachiae 3 parts, Rhizoma Paridis 13 parts, Semen Coicis 3 parts, Folium Ginkgo 3 parts, wild linum 5 parts, Cortex Sclerotii Poriae 4 parts, 4 parts, Rhizoma Gastrodiae.

5. the pharmaceutical composition for the treatment of acute pancreatitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Fructus Aurantii 13 parts, bitter stone connects 11 parts, Herba seu Radix Calanthes 4 parts, Radix Salviae Miltiorrhizae 6 parts, the Rhizoma Pinelliae 13 parts, Rhizoma Corydalis 7 parts, 5 parts, Flos Carthami, Radix Gentianae 18 parts, Rhizoma Imperatae 11 parts, Periostracum Cicadae 9 parts, Rhizoma Fagopyri Dibotryis 4 parts, Herba Houttuyniae 6 parts, Herba Taraxaci 12 parts, Endothelium Corneum Gigeriae Galli 13 parts, Herba Artemisiae Scopariae 4 parts, Rhizoma Chuanxiong 9 parts, Fructus Gardeniae 4 parts, Herba Pyrolae 2 parts, Fructus Crataegi 6 parts, Flos Inulae 6 parts, Herba Sarcandrae 14 parts, Herba Lysimachiae 5 parts, Rhizoma Paridis 10 parts, Semen Coicis 4 parts, Folium Ginkgo 2 parts, wild linum 6 parts, Cortex Sclerotii Poriae 5 parts, 3 parts, Rhizoma Gastrodiae.

6. the pharmaceutical composition for the treatment of acute pancreatitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Fructus Aurantii 17 parts, bitter stone connects 15 parts, Herba seu Radix Calanthes 7 parts, Radix Salviae Miltiorrhizae 11 parts, the Rhizoma Pinelliae 16 parts, Rhizoma Corydalis 8 parts, 8 parts, Flos Carthami, Radix Gentianae 16 parts, Rhizoma Imperatae 14 parts, Periostracum Cicadae 11 parts, Rhizoma Fagopyri Dibotryis 3 parts, Herba Houttuyniae 5 parts, Herba Taraxaci 13 parts, Endothelium Corneum Gigeriae Galli 14 parts, Herba Artemisiae Scopariae 5 parts, Rhizoma Chuanxiong 12 parts, Fructus Gardeniae 3 parts, Herba Pyrolae 1 part, Fructus Crataegi 10 parts, Flos Inulae 9 parts, Herba Sarcandrae 13 parts, Herba Lysimachiae 7 parts, Rhizoma Paridis 11 parts, Semen Coicis 3 parts, Folium Ginkgo 1 part, wild linum 10 parts, Cortex Sclerotii Poriae 4 parts, 4 parts, Rhizoma Gastrodiae.

7. the pharmaceutical composition for the treatment of acute pancreatitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Fructus Aurantii 15 parts, bitter stone connects 12 parts, Herba seu Radix Calanthes 5 parts, Radix Salviae Miltiorrhizae 9 parts, the Rhizoma Pinelliae 15 parts, Rhizoma Corydalis 9 parts, 7 parts, Flos Carthami, Radix Gentianae 19 parts, Rhizoma Imperatae 13 parts, Periostracum Cicadae 10 parts, Rhizoma Fagopyri Dibotryis 4 parts, Herba Houttuyniae 4 parts, Herba Taraxaci 11 parts, Endothelium Corneum Gigeriae Galli 11 parts, Herba Artemisiae Scopariae 5 parts, Rhizoma Chuanxiong 10 parts, Fructus Gardeniae 5 parts, Herba Pyrolae 3 parts, Fructus Crataegi 8 parts, Flos Inulae 8 parts, Herba Sarcandrae 14 parts, Herba Lysimachiae 9 parts, Rhizoma Paridis 12 parts, Semen Coicis 5 parts, Folium Ginkgo 3 parts, wild linum 8 parts, Cortex Sclerotii Poriae 6 parts, 5 parts, Rhizoma Gastrodiae.

8. the pharmaceutical composition for the treatment of acute pancreatitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Fructus Aurantii 19 parts, bitter stone connects 14 parts, Herba seu Radix Calanthes 6 parts, Radix Salviae Miltiorrhizae 7 parts, the Rhizoma Pinelliae 14 parts, Rhizoma Corydalis 9 parts, 6 parts, Flos Carthami, Radix Gentianae 17 parts, Rhizoma Imperatae 13 parts, Periostracum Cicadae 10 parts, Rhizoma Fagopyri Dibotryis 4 parts, Herba Houttuyniae 4 parts, Herba Taraxaci 11 parts, Endothelium Corneum Gigeriae Galli 11 parts, Herba Artemisiae Scopariae 5 parts, Rhizoma Chuanxiong 10 parts, Fructus Gardeniae 5 parts, Herba Pyrolae 3 parts, Fructus Crataegi 8 parts, Flos Inulae 8 parts, Herba Sarcandrae 14 parts, Herba Lysimachiae 4 parts, Rhizoma Paridis 9 parts, Semen Coicis 5 parts, Folium Ginkgo 3 parts, wild linum 8 parts, Cortex Sclerotii Poriae 3 parts, 5 parts, Rhizoma Gastrodiae.

9., according to the pharmaceutical composition of the arbitrary described treatment acute pancreatitis of claim 3-8, it is characterized in that: described pharmaceutical composition is prepared according to following method:

(1) each medical material of components by weight percent in the arbitrary described pharmaceutical composition of claim 3-8 is got, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decoct 1-2 hour: second time adds the water of 8-12 times amount, decoct 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10-1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) pulverized by dry extract obtained for step (2), add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule; Or the dry extract that step (2) is obtained dry, pulverize, and makes powder; Or dry extract obtained for step (2) is pulverized, adds appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or dry extract obtained for step (2) is pulverized, adds suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet; Or to above-mentioned steps (2) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

10. the application of pharmaceutical composition in treatment acute pancreatitis medicine of the treatment acute pancreatitis as described in as arbitrary in claim 1-9.