CN105412633A - Traditional Chinese medicinal composition for treating recurrent aphthous ulcer - Google Patents
Traditional Chinese medicinal composition for treating recurrent aphthous ulcer Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating recurrent aphthous ulcer, belonging to the field of traditional Chinese medicines. The traditional Chinese medicinal composition is prepared from the following raw materials in parts by weight: 20-30 parts of gypsum, 5-15 parts of fructus gardeniae, 5-15 parts of herba lophatheri, 3-9 parts of dried rehmannia root, 3-9 parts of radix et rhizoma rhei, 5-15 parts of immature bitter orange, 3-15 parts of medicated leaven, and 3-15 parts of radix aucklandiae. Compared with the prior art, the traditional Chinese medicinal composition for treating recurrent aphthous ulcer provided by the invention has the advantages that the synergistic effect is strong, a preparation technology is simple and feasible, and the clinical experiment proves that the traditional Chinese medicinal composition has the advantages of small dosage, rapidness in taking effect, short course of treatment, and no relapse after curing.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine composition for the treatment of recurrent aphtha and preparation method thereof.
Background technology
Recurrent aphtha, also known as recurrent aphthous stomatitis, recurrent oral ulceration, recurrent aphtha, it is a kind of disease that in oral keritonocytes, sickness rate is the highest, common cold, dyspepsia, psychentonia, the gloomy situation such as discomfort all accidentally can cause the generation of this disease, be apt to occur in lip, cheek, lingual margin etc., all can occur at any position of mucosa, but attached gingiva and hard palate are then rare completely in keratinization.Age of onset is generally between 10 ~ 30 years old, and women is more, all can occur throughout the year.Recurrent aphtha has self limiting, can spontaneous recovery in about 10 days.This disease has the features such as periodicity, recurrent and self limiting.
The traditional Chinese medical science is thought: oral ulcer belongs to the traditional Chinese medical science " aphtha ", " erosion of the oral mucosa " category.Though aphtha is born in mouth, there is substantial connection with internal organs.The pathogenesis of oral ulcer be mostly accumulation of heat in the heart and spleen, damp-heat in the spleen and stomach, depression of liver-QI, deficiency of both the heart and spleen or deficiency of YIN pathogenic fire superior caused by.Zhang Jingyue cloud: " aphtha is unhealed year after year, this be asthenic fire also." the multifactor body deficiency of YIN of deficiency syndrome, in addition impairment caused by overstrain is excessive, cloudy liquid loss, so that kidney yin is impaired, the not good fire of water, hyperactivity of deficient fire, steams and burns in mouth, for a long time then injured the and ulcer spotting of sarolemma." Plain Questions the most pure virginity will be discussed greatly " is said: " all sufferings skin ulcers, all belong to the heart ".Highlight the heart be aphtha morbidity in crucial internal organs, the fire of aphtha, again not only duty in the heart.Be worried at ordinary times angry, hobby tobacco and wine coffee, surfeit delicious food is thick greasy, all can cause that accumulation of heat in the heart and spleen, lung stomach are hot and suffocating, liver and gall intrinsic heat, sends out as aphtha.Clinical syndrome differentiation typing is generally divided into excess syndrome and deficiency syndrome two kinds, and excess syndrome is many to be caused by the heart, spleen, liver-fire, and deficiency syndrome are common with kidney yin deficiency type.
Current treatment recurrent aphtha, main based on Chinese medicine, the patent of invention of disclosed report has a lot, such as application number: 201310149700.2 disclose the buccal patch that a kind for the treatment of of the inside combined with the outside treats oral ulcer, its Chinese medicine complicated components, and how containing rare Chinese medicine.Application number application number: 201210424704.2 disclose a kind of Chinese medicine for the treatment of oral ulcer, its medicine for external use be made up of the raw material of following weight proportion: Rhizoma Coptidis 30-50, Cortex Phellodendri 30-50, Olibanum 14-26, Myrrha 14-26, Cortex Cinnamomi 14-26, Calamina 30-50, Sanguis Draxonis 30-50, Borneolum Syntheticum 14-26, Margarita 14-26, five OS DRACONIS 14-26, Galla Chinensis 60-100, Borax 90-150, Radix Glycyrrhizae 30-50, Indigo Naturalis 30-50.Application number: 201210297173.5 1 kinds of medicines for the treatment of recurrent oral ulceration and preparation method thereof, select Rhizoma Alismatis, Rhizoma Coptidis, Plumula Nelumbinis, Fructus Gardeniae, Poria, Radix Scutellariae, Radix Rehmanniae, Radix Glycyrrhizae, Radix Ophiopogonis, Caulis Akebiae, Folium Bambusae, Rhizoma Imperatae, Rhizoma Phragmitis, Fructus Ligustri Lucidi and Cortex Lycii carry out combining, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat the recurrence of recurrent oral ulceration.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of recurrent aphtha, this Chinese medicine composition is formed by clinic tests and repeated verification configuration, have treating both the principal and secondary aspects of a disease, more after the feature that do not recur.
The invention provides following technical scheme:
Treat a pharmaceutical composition for recurrent aphtha, it is made up of following medical material compatibility: Gypsum Fibrosum, Fructus Gardeniae, Herba Lophatheri, Radix Rehmanniae, Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus, Massa Medicata Fermentata and the Radix Aucklandiae.
Preferably, it is prepared from by the raw material of following weight proportioning:
Gypsum Fibrosum 20-30 weight portion, Fructus Gardeniae 5-15 weight portion, Herba Lophatheri 5-15 weight portion, Radix Rehmanniae 3-9 weight portion, Radix Et Rhizoma Rhei 3-9 weight portion, Fructus Aurantii Immaturus 5-15 weight portion, Massa Medicata Fermentata 3-15 weight portion and Radix Aucklandiae 3-15 weight portion.
Most preferably, it is prepared from by the raw material of following weight proportioning:
Gypsum Fibrosum 24 weight portion, Fructus Gardeniae 10 weight portion, Herba Lophatheri 10 weight portion, Radix Rehmanniae 6 weight portion, Radix Et Rhizoma Rhei 3 weight portion, Fructus Aurantii Immaturus 9 weight portion, Massa Medicata Fermentata 9 weight portion and the Radix Aucklandiae 10 weight portion.
The source of each taste Chinese crude drug of the present invention, meridian distribution of property and flavor, function cures mainly and is discussed below:
Gypsum Fibrosum: be Sulfates mineral anhydrite race Gypsum Fibrosum.Removing silt and assorted stone, forge use.
Meridian distribution of property and flavor: sweet, pungent, Great Cold.Attach to the lung and stomach meridians.
Function cures mainly: expelling pus and promoting granulation, removing dampness, hemostasis.For oral administration be mainly used in epidemic febrile disease edema caused by disorder of QI excess-heat syndrome, dyspnea and cough due to lung-heat card, stomach-fire headache, toothache, excess-heat quench one's thirst.
Fructus Gardeniae: be the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae GardeniajasminoidesEllis.Raw use.
Meridian distribution of property and flavor: bitter, cold.GUIXIN, lung, tri-jiao channel.
Function cures mainly: pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Be mainly used in that calentura is vexed, jaundice due to damp-heat, blood strangury and dry pain, heat in blood tell nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles etc.
Herba Lophatheri: be the dry stem and leaf of grass Herba Lophatheri LophatherumgracileBrongn Wilsonii.Summer end taps before taking out spica, dries cutting, raw use.Meridian distribution of property and flavor: sweet, light, cold.GUIXIN, stomach, small intestine meridian.
Function cures mainly: clearing away heat-fire, relieving restlessness, diuresis.Be mainly used in calentura excessive thirst, aphtha dark coloured urine, the puckery pain of pyretic stranguria etc.
Radix Rehmanniae: be the fresh of scrophulariaceae rehmannia glutinosa plant RehmanniaglutinosaLibosch or dried root.Autumn excavates, and removes reed head, fibrous root and silt.Using fresh herb, or dry raw use.
Meridian distribution of property and flavor: sweet, bitter, cold.GUIXIN, liver, kidney channel.
Function cures mainly: clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.Be mainly used in that heat enters nutrient blood, crimson tongue excessive thirst, macule tell nosebleed, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, Tianjin wound are thirsty, interior-heat is quenched one's thirst, dryness of the intestine constipation etc.
Radix Et Rhizoma Rhei: be the dry root and rhizome of polygonum rheum palmatum RheumpalmatumL, Rheum tanguticum RtanguticumMaximexBalf or Rheum officinale RofficinaleBaill.Excavate before autumn Mo, the stem and leaf withered or secondary spring germinateed.Removing fibrous root, scrapes off crust stripping and slicing dry, raw use.
Meridian distribution of property and flavor: bitter, cold.Return spleen, stomach, large intestine, liver, pericardium channel.
Function cures mainly: heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Be mainly used in stagnant constipation, delirium is gone mad ， lumps in the chest and abdomen, and heat in blood tells nosebleed, conjunctival congestion pharyngeal swelling, pathopyretic ulcer, burn and scald, all cards of blood stasis amenorrhea, hygropyretic dysentery, jaundice, edema stranguria etc.
Fructus Aurantii Immaturus: be the dry young fruit of rutaceae Citrus aurantium Linn. CitrusaurantiumL Wilsonii and variety or Fructus Citri sinensis C Wilsonii sinensisOsbeck.Used time is clean, vexed, shave, dry.Raw use.
Meridian distribution of property and flavor: bitter, pungent, sour, temperature.Return spleen, stomach, large intestine channel.
Function cures mainly: dispelling the stagnated QI removing food stagnancy, reduces phlegm except painful abdominal mass.Be mainly used in gastrointestinal retention gastral cavity abdomen feeling of fullness, stomachache constipation, or damp-heat dysentery, tenesmus, and the stagnant feeling of oppression and fullness in the chest and epigastrium of expectorant, thoracic obstruction blocked-up chest, puerperal abdonimal pain, stagnation of QI pain in chest and hypochondrium.
Massa Medicata Fermentata: for a large amount of flour, Testa Tritici mix with appropriate fresh Herba polygoni hydropiperis, fresh Herba Artemisiae Annuae, Semen Armeniacae Amarum, Semen Phaseoli powder and fresh Herba Xanthii after processed goods through fermenting.Raw with being used as medicine.
Meridian distribution of property and flavor: sweet, acrid, warm.Return spleen, stomach warp.
Function cures mainly: invigorating the spleen and regulating the stomach, helps digestion in adjusting.Be mainly used in that food stagnation does not disappear, distension and fullness in the abdomen, anorexia, insufficiency of the spleen dyspepsia, borborygmus diarrhoea etc.The illness that doctor trained in Western medicine is examined as dyspepsia and other stomach functions belongs to food stagnation card person.
The Radix Aucklandiae: be the root of feverfew Radix Aucklandiae AucklandialappaDecne, Radix Vladimiriae Vladimirasouliei (Franch) Ling.Autumn and winter season excavates, removing silt and fibrous root, and cut off, large vertical profile again becomes lobe, hits rough bark after drying.Raw use.
Meridian distribution of property and flavor: pungent, bitter, temperature.Return spleen, stomach, large intestine, gallbladder, tri-jiao channel.
Function cures mainly: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.Be mainly used in stagnation of QI in spleen and stomach card, dysentery tenesmus, stomachache hypochondriac pain, jaundice, hernia pain, the qi depression to blood stasis thoracic obstruction etc.
Prescription analysis of the present invention:
In side of the present invention, Gypsum Fibrosum acrid-sweet flavor is cold in nature, forges rear cold and cool property and subtracts greatly, energy putrefaction removing and tissue regeneration promoting, removing dampness sore, and detumescence hemostasis is the monarch drug of the present invention.The light property of Fructus Gardeniae body float, bitter cold is fallen clearly, and gas savoury falls, can purte the white, the heat that clears away heart-fire, remove stagnant heat, You Shanqing rushes down the fire of three Jiao, has the effect of the relieving restlessness that clears away heart-fire, can be used for epidemic febrile disease, pathogenic heat visitor the heart, vexed gloomy, restlessness is not peaceful.Fructus Gardeniae gas is clear and tremble with fear, energy expelling pathogenic factors from muscles table, rushes down damp and hot, diuresis.Fructus Gardeniae joins Gypsum Fibrosum: Gypsum Fibrosum energy clearing away heat-fire, expelling pathogenic factors from muscles relieving restlessness, directly enters spleen with removing summer-heat volt fire; Fructus Gardeniae bitter cold is fallen and is let out, gently up clearly, can clear thorough under, the heat of the exterior and the interior can be bilingual, the double relieving restlessness that can clear away heart-fire.Two medicine adapteds, heart spleen two is clear, and make interior strongly fragrant fieryly must to separate, the fiery of upper inflammation must fall apart.The light gas of Herba Lophatheri body is thin, sweet in the mouth and trembling with fear, the sharp key of light energy, thus can clearing away heart-fire, relieving thirst and restlessness, eliminating dampness by diuresis heat, except stomach-fire, reach flesh table, separate pathogenic heat.Herba Lophatheri joins Gypsum Fibrosum: Gypsum Fibrosum is apt to clearing stomach fire; Herba Lophatheri energy clearing heat and relieving fidgetness and diuresis.Two medicine compatibilities, have clearing away heat-fire, a merit that relieving restlessness is quenched the thirst.The sweet cold phencyclidine of Radix Rehmanniae, has effect of cooling blood for hemostasis.Gypsum Fibrosum joins Radix Rehmanniae: the air supporting of Gypsum Fibrosum acrid in the mouth, walks expelling pathogenic factors from muscles heat outward, inside walks to let out stomach-fire, and relatively lose heart a point excess-heat; The Radix Rehmanniae xanthin profit and oiliness, be longer than clearing away heat and cooling blood and stop blooding, and having the merit of YIN nourishing and the production of body fluid promoting.Two medicine adapteds, can clearing heat in QI system divides, the heat of blood system to be to protect cloudy liquid.Therefore above Fructus Gardeniae, Herba Lophatheri and Radix Rehmanniae are ministerial drug altogether.Radix Et Rhizoma Rhei is bitter and partially fall, and cold energy heat-clearing and toxic substances removing, had both entered edema caused by disorder of QI, and entered again blood system, sedimentation defecating feces excretion can be borrowed to make the pathogenic fire pyretic toxicity of inflammation obtain following letting out, have the merit of purging fire and cooling blood removing toxic substances.Radix Et Rhizoma Rhei joins Gypsum Fibrosum Preparatum: Radix Et Rhizoma Rhei clearing away heat,cooling blood and removing toxin; Gypsum Fibrosum Preparatum expelling pus and promoting granulation.Two medicine compatibilities, removing pathogenic heat from blood and toxic substance from the body, dampness granulation promoting.Radix Et Rhizoma Rhei joins Radix Rehmanniae: clearing away heat and nourishing YIN and just do not hinder, cooling blood for hemostasis and do not stay the stasis of blood.The pungent loose hardship of Fructus Aurantii Immaturus is fallen, and energy promoting the circulation of QI and reducing phlegm is with the painful abdominal mass that disappears, and dispelling the stagnated QI is except completely pain relieving.Fructus Aurantii Immaturus is joined Massa Medicata Fermentata circulation of qi promoting and to be disappeared painful abdominal mass, dyspepsia and intestinal stasis relieving.Therefore above Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus are adjuvant drug altogether.The Radix Aucklandiae pungent perfume row is loose, and bitter cooling is logical, can circulation of qi promoting stagnant, relieving distension pain relieving, dredging mechanism of qi, declares stagnant in tune, make medicine for the present invention.All taste medical material 5 use, can play effect of monarch above, plays clearing away heart-fire altogether, except stomach-fire, hot and suffocating clearly, drying damp and strengthening spleen, can sore swollen toxin in purged body, thus reaches putrefaction removing and tissue regeneration promoting, removing dampness sore, the effect for the treatment of oral ulcer.
The present invention treats the Chinese medicine preparation of the pharmaceutical composition of recurrent aphtha, preparation technology is simple, can add pharmaceutically acceptable carrier when being prepared into medicament, described pharmaceutically acceptable carrier is including but not limited to mannitol, silicon derivative, polyvinylpyrrolidone, glycerol, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate, starch, sucrose, lactose, POLYSORBATE 80, agar, calcium carbonate, cellulose family and derivant thereof, alginate, gelatin, cyclodextrin, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin.
Chinese medicine preparation of the present invention can be any dosage form that can be oral, and these dosage forms include but not limited to: oral liquid, tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, buccal tablet, granule, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, patch.
Preferably peroral dosage form of the present invention is tablet, oral liquid, buccal tablet, capsule or granule.
The present invention also provides a kind of preparation method being used for the treatment of the pharmaceutical composition of recurrent aphtha, mainly comprises following steps: clean ingredients, weighs by weight portion of the present invention, 100-200 mesh sieve is crossed after pulverizing, mixing, sterilizing, prepares various pharmaceutical preparation.
Compared with prior art, the pharmaceutical composition synergism that the present invention treats recurrent aphtha is strong, and preparation is simple, and clinical experiment confirms, it is little that Chinese medicine composition of the present invention has dose dosage, instant effect, short treating period, the advantage of non-relapse after healing.
Detailed description of the invention
Below will further illustrate the present invention by specific embodiment, but it should be appreciated by those skilled in the art that the specific embodiment of the invention and do not limit the present invention in any way.Take up an official post on basis of the present invention and how all fall within protection scope of the present invention with replacement.
Embodiment 1
Prescription:
Gypsum Fibrosum 24 weight portion, Fructus Gardeniae 10 weight portion, Herba Lophatheri 10 weight portion, Radix Rehmanniae 6 weight portion, Radix Et Rhizoma Rhei 3 weight portion, Fructus Aurantii Immaturus 9 weight portion, Massa Medicata Fermentata 9 weight portion and the Radix Aucklandiae 10 weight portion.
Preparation method: each Chinese crude drug taking above-mentioned weight portion, drying and crushing, cross 200 mesh sieves, mix homogeneously, is prepared into capsule.Every capsules is containing crude drug 0.4g
Embodiment 2
Prescription:
Gypsum Fibrosum 30 weight portion, Fructus Gardeniae 15 weight portion, Herba Lophatheri 15 weight portion, Radix Rehmanniae 9 weight portion, Radix Et Rhizoma Rhei 9 weight portion, Fructus Aurantii Immaturus 15 weight portion, Massa Medicata Fermentata 15 weight portion and the Radix Aucklandiae 15 weight portion.
Preparation method: each Chinese crude drug taking above-mentioned weight portion, pulverizes, and cross 120 mesh sieves, mix homogeneously, sterilizing, inserts capsule, obtains capsule of the present invention.
Embodiment 3
Prescription:
Gypsum Fibrosum 20 weight portion, Fructus Gardeniae 15 weight portion, Herba Lophatheri 5 weight portion, Radix Rehmanniae 3 weight portion, Radix Et Rhizoma Rhei 6 weight portion, Fructus Aurantii Immaturus 9 weight portion, Massa Medicata Fermentata 6 weight portion and the Radix Aucklandiae 15 weight portion.
Preparation method: each Chinese crude drug taking above-mentioned weight portion, pulverizes, and cross 150 mesh sieves, mix homogeneously, sterilizing, inserts No. 0 capsule, obtain capsule of the present invention.
Embodiment 4
Prescription:
Gypsum Fibrosum 25 weight portion, Fructus Gardeniae 10 weight portion, Herba Lophatheri 10 weight portion, Radix Rehmanniae 5 weight portion, Radix Et Rhizoma Rhei 5 weight portion, Fructus Aurantii Immaturus 10 weight portion, Massa Medicata Fermentata 15 weight portion and the Radix Aucklandiae 5 weight portion.
Preparation method: each Chinese crude drug taking above-mentioned weight portion, pulverizes, and cross 100 mesh sieves, mix homogeneously, sterilizing, adds the adjuvants such as starch, and tabletting obtains Tablets.
Embodiment 5
Prescription:
Gypsum Fibrosum 28 weight portion, Fructus Gardeniae 6 weight portion, Herba Lophatheri 6 weight portion, Radix Rehmanniae 9 weight portion, Radix Et Rhizoma Rhei 6 weight portion, Fructus Aurantii Immaturus 5 weight portion, Massa Medicata Fermentata 4 weight portion and the Radix Aucklandiae 3 weight portion.
Preparation method: each Chinese crude drug taking above-mentioned weight portion, pulverizes, and cross 200 mesh sieves, mix homogeneously, sterilizing, adds the adjuvants such as starch, correctives, sucrose, granulates, and pack, obtains granule of the present invention.
Clinical data
1, in August ,-2015 in January, 2012 medical 160 routine recurrent aphtha patients of institute are chosen as object of study.Wherein man 100 example, female 60 example; Minimum patient 16 years old, maximum patient 64 years old, the course of disease 6 months 11 years, is oral ulcer recurrent exerbation person, is diagnosed as recurrent aphtha.
160 patients are divided into treatment group and matched group at random, and two groups of sexes, age contrasts are checked all without significant difference (P > 0.05) through t.
2 diagnostic criterias
2.1 Western medicine diagnose standards adopt the diagnostic criteria in " Diseases of the Oral Mucosa ":
1. occur single or several aphtha with oral mucosa, scorching hot pain is cardinal symptom;
2. onset is very fast, and the course of disease is longer, rises one after another, normal easily recurrence more;
3. from the beginning of occurring one or more small red dots or phlysis on oral mucosa, Semen phaseoli radiati or the large aphtha of Semen Glycines is formed, ulcer ovalize;
4. its surface is covered with yellow-white pseudomembrane more, and surrounding is around with blush.
2.2 tcm diagnosis standards define the traditional Chinese medical science inclusive criteria of this research according to " Chinese medicine encyclopedia stomatology ":
1. body constitution is better or general;
2. aphtha recurrent exerbation;
3. base, local is red red or light red, skin ulcer week redness obviously or not very, the many yellow or white secretions in surface;
4. red tongue or light red yellow and thin fur or yellow greasy, rapid pulse or moisten.
3 Therapeutic Method
Treatment group: give capsule prepared by the embodiment of the present invention 1, every day 2 times, each 4,7 days courses for the treatment of, 2 courses for the treatment of of continued treatment.
Matched group: select levamisole (25mg/ sheet), every day 3 times is oral, and each 50mg, vitamin B2, every day 3 times, each 20mg, takes 14 days continuously.
4 criterions of therapeutical effect
Recovery from illness: after taking medicine 14 days, oral mucosa damaged area pain is eliminated, ulcer surface disappears, and follows up a case by regular visits to 1 year without recurrence;
Effective: after taking medicine 14 days, the elimination of oral mucosa damaged area pain, ulcer surface disappear, follow up a case by regular visits to 6 months without recurrence;
Invalid: after taking medicine 14 days, oral mucosa damaged area pain slightly alleviates, ulcer surface change is little, recurrent exerbation.
5 statistical method
Data acquisition SPSS18.0 software carries out statistical analysis, measurement data with
represent, before and after treatment, Indexes Comparison adopts t inspection; Enumeration data adopts X
2inspection.P < 0.05 represents that difference has statistical significance.
6 experimental results
See table 1.
Comparitive study before and after table 1 liang group treatment
Note: compare with matched group:
#p < 0.01
Through following up a case by regular visits to, final its curative effect of therapeutic outcome display treatment group is obviously better than matched group, and two groups of comparitive study have pole significant difference, have statistical significance (p < 0.01).
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Model case
Case 1: Lee, man, 50 years old, patient's private prosecution: oral ulcer 7 or eight years, recurrent exerbation, every other month or the several months morbidity once.Through looking into: there is ulcer point 6, infections dot center nick turns white, and around blush, is diagnosed as recurrent aphtha.Take the embodiment of the present invention 1 capsule, after 3 days, pain disappears, and all transference cures after 7 days, continue to take 2 weeks, follows up a case by regular visits to 1 year without recurrence, thoroughly cures.
Case 2: Lee, female, 32 years old.Patient's private prosecution suffers from recurrent aphtha 5 years, and show effect all hurt like hells at every turn, takes neither bite nor sup of the food.Through looking into: there is ulcer point 7, traditional Chinese medical science disease sees that bitter taste in the mouth and dry throat, agitation, yellow urine are few, red tongue, yellow and greasy fur, stringy and rolling pulse etc., is diagnosed as recurrent aphtha.Take the embodiment of the present invention 1 capsule, after 3 days, pain disappears, and all transference cures after 7 days, continue to take 2 weeks, follows up a case by regular visits to 1 year without recurrence, thoroughly cures.
Claims (6)
1. treat a Chinese medicine composition for recurrent aphtha, it is characterized in that, it is prepared from by following medical material compatibility: Gypsum Fibrosum, Fructus Gardeniae, Herba Lophatheri, Radix Rehmanniae, Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus, Massa Medicata Fermentata and the Radix Aucklandiae.
2. treat a Chinese medicine composition for recurrent aphtha, it is characterized in that, it is prepared from by the raw material of following weight proportioning:
Gypsum Fibrosum 20-30 weight portion, Fructus Gardeniae 5-15 weight portion, Herba Lophatheri 5-15 weight portion, Radix Rehmanniae 3-9 weight portion, Radix Et Rhizoma Rhei 3-9 weight portion, Fructus Aurantii Immaturus 5-15 weight portion, Massa Medicata Fermentata 3-15 weight portion and Radix Aucklandiae 3-15 weight portion.
3. treat a Chinese medicine composition for recurrent aphtha, it is characterized in that, it is prepared from by the raw material of following weight proportioning:
Gypsum Fibrosum 24 weight portion, Fructus Gardeniae 10 weight portion, Herba Lophatheri 10 weight portion, Radix Rehmanniae 6 weight portion, Radix Et Rhizoma Rhei 3 weight portion, Fructus Aurantii Immaturus 9 weight portion, Massa Medicata Fermentata 9 weight portion and the Radix Aucklandiae 10 weight portion.
4. Chinese medicine composition as described in claim 1-3, it is characterized in that, pharmaceutically acceptable carrier can be added when being prepared into medicament, described pharmaceutically acceptable carrier including but not limited to: the pharmaceutically acceptable carrier of described medicament including but not limited to mannitol, silicon derivative, polyvinylpyrrolidone, glycerol, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate, starch, sucrose, lactose, POLYSORBATE 80, agar, calcium carbonate, cellulose family and derivant thereof, alginate, gelatin, cyclodextrin, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin.
5. Chinese medicine composition as claimed in claim 4, it is characterized in that, described medicament is peroral dosage form.
6. Chinese medicine composition as claimed in claim 5, it is characterized in that, described peroral dosage form includes but not limited to: oral liquid, tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, buccal tablet, granule, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, patch, is preferably capsule.
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Cited By (1)
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| CN109700881A (en) * | 2019-03-07 | 2019-05-03 | 张春梅 | For treating external application type Traditional Chinese medicine composition patch, preparation and its application of canker sore |
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| CN102670822A (en) * | 2012-04-29 | 2012-09-19 | 李月英 | Chinese herba preparation for treating oral ulcer |
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| CN109700881A (en) * | 2019-03-07 | 2019-05-03 | 张春梅 | For treating external application type Traditional Chinese medicine composition patch, preparation and its application of canker sore |
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Application publication date: 20160323 |