CN104435957A - Preparation method of Chinese medicinal preparation for treating lung abscess - Google Patents

Abstract

The invention discloses a preparation method of a Chinese medicinal preparation for treating lung abscess. The Chinese medicinal preparation is prepared from the following raw medicinal materials: houttuynia, siraitia grosvenorii, white strawberry, fritillaria, glossocardia bidens, radix scutellariae, sweet wormwood, heynea trijuga, mutton tallow, wolfberry, polygonum multiflorum, Chinese honeylocust spine, gingko, asparagus, mulberry leaves, bupleurum, medicated leaven, sharpleaf galangal fruit, polygonatum odoratum, rhinacanthus nasutus, sinkiang fritillary bulb, American ginseng, dwarf lilyturf tuber and honey. The formulation of the Chinese medicament is a pill, and the pill is prepared by the processes of preparing powder, preparing an extract, mixing the powder and the extract, then adding the honey and kneading the mixture into the pill. Compared with the prior art, the Chinese medicinal preparation has the effects of clearing heat and detoxifying, dredging qi and moistening lungs, nourishing the stomach and spleen, nourishing yin and relieving focuses and has strong pertinency.

Description

A kind of preparation method for the treatment of the Chinese medicine preparation of pulmonary abscess

Technical field

The present invention relates to pharmaceutical technology, particularly a kind of preparation method for the treatment of the Chinese medicine preparation of pulmonary abscess.

Background technology

Pulmonary abscess is the lung tissue purulent lesion caused by Different types of etiopathogenises.Early stage is suppurative inflammation, then downright bad formation abscess.Multiplely be born in the prime of life, man is more than female.Have through the infection caused by trachea infection, Hematogenous infection and the blocking such as multiple abscess and pulmonary carcinoma according to pathogenic factor.Pulmonary abscess also can be sorted out, as staphylococcic, anaerobe or aspergillosis pulmonary abscess according to relevant cause of disease.Since antibiotic extensive use, the incidence rate of pulmonary abscess greatly reduces.

The factor that pulmonary abscess occurs is bacteriological infection, bronchial obstruction, adds that systemic resistance power reduces.Primary abscess causes because suck pathogenic bacterium or pneumonia, and secondary abscess is on the basis of existing pathological changes (as blocking), and by sending out outside lung, bronchiectasis and (or) immunosuppressive condition cause.

Pulmonary abscess belongs to the category of traditional Chinese medical science lung abscess.The cause of disease comprises:

1, the heresy of being invaded by exogenous pathogen affection due to external wind and heat, invasion and attack lung is defended, or the heresy be affected by the cold, does not with the passing of time heal, strongly fragrant and heat-transformation, and pathogenic heat are stopped up and held back in lung, and the lung network stasis of blood is stagnant, and the hot stasis of blood is tied mutually and formed pulmonary abscess.

2, phlegm-heat accumulated in the lung is due to eating and drinking without temperance, addicted to the product that food delicious food is pungent; Or be addicted to drink excessively, grow damp and hot one-tenth expectorant; Or lung gold have stagnation of phlegm-heat; Or because of overfatigue, lung is defended not solid, and exopathogen is invaded in taking advantage of a weak point in opponent's defence, inside and outside combined pathogens, and causes accumulation of phlegm-heat in the interior, steams and burns in lung, forms pulmonary abscess.

In existing therapeutic process, doctor trained in Western medicine generally adopts antibiosis usually to treat, but the sequela that antibiotic brings is self-evident, can produce larger side effect to patient body; Then based on hot lung moistening of dispelling in Chinese traditional treatment, all cannot take into account for lung heat clearing, removing toxic substances, evacuation of pus, YIN nourishing, cause treating the relapse rate of rear a period of time higher, patient then carry out western medical treatment.

In addition, due to lung governing qi, spleen QI invigorating; The lung being the upper source of fluids, The spleen has the function to transport and transform nutrients, and water wets, so the relation of lung and the spleen large factor that to be also relapse rate higher, namely the common traditional Chinese medical science only treats pulmonary, but do not take into account spleen, but lung is the pivot of main gas, spleen is the source of anger: lung governing qi, spleen QI invigorating, both mutually promote, and form the gas of the day after tomorrow; The lung being the utensil for storing phlegm, the spleen being the source of producing phlegm: spleen answers transmitting and distributing the fluids, lung answers regulating fluid apssage.If pulmonary abscess recurs, just easily produce the deficiency of the lung → insufficiency of the spleen → such a bad circulation of suffering from a deficiency of the kidney, thus while treatment pneumonopathy, spleen invigorating is also the most important thing.

Based on this, now provide a kind of preparation method for the treatment of the Chinese medicine preparation of pulmonary abscess, the method is started with from aspects such as spleen, pulmonary lesions, removing toxic substances, damp eliminating, heat clearing away, realizes the treating both the principal and secondary aspects of a disease to pulmonary abscess.

Summary of the invention

The technical problem to be solved in the present invention is to provide a kind of preparation method of Chinese medicine preparation of practical, treatment pulmonary abscess that result of use is desirable.

In order to realize foregoing invention object, the invention provides a kind of preparation method for the treatment of the Chinese medicine preparation of pulmonary abscess, comprise the raw medicinal material of following ratio of weight and number: the raw medicinal material comprising following ratio of weight and number: Herba Houttuyniae, Fructus Momordicae, Herba Fragariae nilerrensis, Bulbus Fritillariae Cirrhosae, Herba Glossogynes tenuifoliae, Radix Scutellariae, Herba Artemisiae Annuae, Radix heyneae trijugae, Adeps caprae seu ovis, Fructus Lycii, Radix Polygoni Multiflori, sky fourth, Semen Ginkgo, Radix Asparagi, Folium Mori, Radix Bupleuri, Massa Medicata Fermentata, Fructus Alpiniae Oxyphyllae, Rhizoma Polygonati Odorati, Ramulus et Folium Rhinacanthi nasuti, Bulbus Fritillariae Pallidiflorae, Radix Panacis Quinquefolii, Radix Ophiopogonis, Mel;

The dosage form of described Chinese medicine is pill, and its concrete preparation process is:

Step one: first by Fructus Momordicae, Herba Fragariae nilerrensis, Bulbus Fritillariae Cirrhosae, Herba Glossogynes tenuifoliae, Radix heyneae trijugae, Adeps caprae seu ovis, Fructus Lycii, Radix Polygoni Multiflori, sky fourth, Semen Ginkgo, Radix Asparagi, Ramulus et Folium Rhinacanthi nasuti, Bulbus Fritillariae Pallidiflorae, Radix Panacis Quinquefolii, mixing Radix Ophiopogonis, dry in 50-70 DEG C of environment, obtain powder after grinding, cross 80-100 mesh sieve;

Step 2: get the surplus stock medical material mixing except Mel again, add 50-60% soak with ethanol 3 hours, the heating extraction 3 times relative to mixture 3-5 times amount, each 45-55 minute, merge three extracting solution, cross 100-120 mesh sieve after filter, when filtrate is evaporated to 75-80 DEG C, relative density is the extractum of 1.08-1.12, becomes component one;

Step 3: step 2 Chinese medicine slag is added 2-3 times amount water soaking 3 hours, once, extraction time is 45-55 minute to heating extraction, and thickening filtration is extractum shape, is component two;

Step 4: said components one and component 2 two kinds of extractum are condensed into pasty state, add the powder that step one obtains, add Mel and be twisted into pill.

Further, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 12-22 part, Fructus Momordicae 15-30 part, Herba Fragariae nilerrensis 10-20 part, Bulbus Fritillariae Cirrhosae 10-25 part, Herba Glossogynes tenuifoliae 8-16 part, Radix Scutellariae 16-25 part, Herba Artemisiae Annuae 6-22 part, Radix heyneae trijugae 1-10 part, Adeps caprae seu ovis 7-19 part, Fructus Lycii 5-25 part, Radix Polygoni Multiflori 10-22 part, it fourth 20-35 part, Semen Ginkgo 3-12 part, Radix Asparagi 20-40 part, Folium Mori 10-28 part, Radix Bupleuri 10-26 part, Massa Medicata Fermentata 18-32 part, Fructus Alpiniae Oxyphyllae 26-35 part, Rhizoma Polygonati Odorati 25-32 part, Ramulus et Folium Rhinacanthi nasuti 12-24 part, Bulbus Fritillariae Pallidiflorae 10-28 part, Radix Panacis Quinquefolii 5-20 part, Radix Ophiopogonis 25-40 part, Mel 5-15 part.

Further, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 15-20 part, Fructus Momordicae 16-25 part, Herba Fragariae nilerrensis 12-18 part, Bulbus Fritillariae Cirrhosae 15-22 part, Herba Glossogynes tenuifoliae 10-15 part, Radix Scutellariae 18-23 part, Herba Artemisiae Annuae 10-20 part, Radix heyneae trijugae 2-6 part, Adeps caprae seu ovis 10-15 part, Fructus Lycii 10-20 part, Radix Polygoni Multiflori 12-18 part, it fourth 25-32 part, Semen Ginkgo 5-10 part, Radix Asparagi 25-35 part, Folium Mori 12-25 part, Radix Bupleuri 12-23 part, Massa Medicata Fermentata 22-30 part, Fructus Alpiniae Oxyphyllae 28-32 part, Rhizoma Polygonati Odorati 26-30 part, Ramulus et Folium Rhinacanthi nasuti 15-22 part, Bulbus Fritillariae Pallidiflorae 15-25 part, Radix Panacis Quinquefolii 10-15 part, Radix Ophiopogonis 28-35 part, Mel 8-12 part.

As preferably, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 18 parts, Fructus Momordicae 20 parts, Herba Fragariae nilerrensis 15 parts, Bulbus Fritillariae Cirrhosae 20 parts, Herba Glossogynes tenuifoliae 12 parts, Radix Scutellariae 20 parts, Herba Artemisiae Annuae 15 parts, Radix heyneae trijugae 5 parts, Adeps caprae seu ovis 12 parts, Fructus Lycii 15 parts, Radix Polygoni Multiflori 15 part, day fourth 30 parts, Semen Ginkgo 8 parts, Radix Asparagi 30 parts, 20 parts, Folium Mori, Radix Bupleuri 15 parts, Massa Medicata Fermentata 25 parts, Fructus Alpiniae Oxyphyllae 30 parts, Rhizoma Polygonati Odorati 28 parts, Ramulus et Folium Rhinacanthi nasuti 20 parts, Bulbus Fritillariae Pallidiflorae 20 parts, Radix Panacis Quinquefolii 12 parts, Radix Ophiopogonis 30 parts, Mel 10 parts.

Powder after grinding in described step one crosses 90 mesh sieves, and the extracting solution in step 2 crosses 110 mesh sieves.

Temperature in described step one is 60 DEG C.

Ethanol mass percent in described step 2 is 55%.

The time of at every turn extracting concentrated solution in described step 2 and step 3 is 50 minutes.

The dosage form of described Chinese medicine also can be made into granule, and its concrete preparation process is:

Step one: described raw medicinal material is mixed in described ratio, cross 100 mesh sieves after grinding to form granule, be placed in and decoct marmite, add three times of water soakings of mixture weight, soak time is 30 minutes;

Step 2: be heated to boil, changes slow fire and boils 15 minutes, then isolate decoction liquor;

Step 3: after the water adding isolated medicinal residues weight three times repeats to boil, change slow fire and boil 15 minutes, then isolate decoction liquor;

Step 4: collect twice decoction liquor, centrifugalize, when being evaporated to 70-80 DEG C under vacuum 0.08-0.10Mpa, relative density is the mastic of 1.22-1.35, spraying dry, inlet temperature 100-110 DEG C, leaving air temp 90-95 DEG C of spray dryer, be ground into powder subsequently, make dried cream powder;

Step 5: the beta-schardinger dextrin-adding cane sugar powder relative to dried cream powder quality 0.4 ~ 0.6 times and 0.3 ~ 0.4 times in the dried cream powder obtained, makes granule, dry in 70 DEG C of environment, obtains granule.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Herba Houttuyniae: nature and flavor are pungent, is slightly cold.Return lung meridian.Heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome, is mainly used to lung abscess vomiting pus, and expectorant dyspnea of heat type is coughed, hematodiarrhoea, pyretic stranguria, carbuncle sore tumefacting virus.

Fructus Momordicae: nature and flavor are sweet is cool.Return lung, large intestine channel.Clearing heat and moistening lung, laxation relieving constipation.For lung-fire cough caused by dryness, pharyngalgia aphonia, dryness of the intestine constipation.

Herba Fragariae nilerrensis: nature and flavor are sweet, bitter; Cool.Return lung; Liver; Kidney channel.Clearing away lung-heat to relieve cough, removing toxic substances and promoting subsidence of swelling, main cough due to lung-heat; Pertussis; Aphtha of the mouth and tongue; Furuncle; Venom, burn and scald.

Bulbus Fritillariae Cirrhosae: nature and flavor are bitter, sweet, are slightly cold.Return lung, heart channel.Clearing heat and moistening lung, preventing phlegm from forming and stopping coughing, is mainly used to lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.

Herba Glossogynes tenuifoliae: nature and flavor are micro-pungent, cool.Clearing away heat-damp and promoting diuresis, cures mainly heatstroke and vomits and diarrhoea, dysentery, damp and hot edema, gingivitis, backache, herpes zoster.

Radix Scutellariae: nature and flavor are bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, be mainly used to hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Herba Artemisiae Annuae: nature and flavor bitter, acrid, cold.Return liver, gallbladder meridian.Clearing away summer-heat, except steaming, preventing the attack (or recurrence) of malaria, is mainly used to pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.

Radix heyneae trijugae: nature and flavor are bitter, cool, slightly poisonous.Heat-clearing and toxic substances removing, wind-damp dispelling, throat, cures mainly rheumatic arthritis, lumbago, skelalgia of rheumatism, pharyngolaryngitis, tonsillitis, the heart, peratodynia.

Adeps caprae seu ovis: nature and flavor are sweet, temperature.Tonify deficiency, moisturizes, and dispels the wind, removing toxic substances, cures mainly asthenia weakness and emaciation, and skin is withered thin and pallid, chronic dysentery, erysipelas, skin ulcer tinea.

Fructus Lycii: nature and flavor are sweet is flat.Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight, for asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.

Radix Polygoni Multiflori: nature and flavor are bitter, sweet, puckery, temperature.Return liver, the heart, kidney channel.Removing toxic substances, eliminating carbuncle, loosening bowel to relieve constipation, is mainly used to scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.

It fourth: have another name called Spina Gleditsiae, nature and flavor are pungent, temperature.Return liver, stomach warp.Detumescence poison holding, evacuation of pus, parasite killing.

Semen Ginkgo: nature and flavor are sweet, bitter, puckery, flat; Poisonous.Return lung meridian.Astringing lung QI for relieving asthma, leukorrhagia stopping is turbid, urine reducing, is mainly used to abundant expectoration and breathes with cough, leukorrhagia nebulousurine, enuresis frequent micturition.

Radix Asparagi: nature and flavor are sweet, bitter, cold.Return lung, kidney channel.Nourishing YIN to relieve dryness, lung heat clearing is promoted the production of body fluid, and is mainly used to dryness of the lung dry cough, and pertussis expectorant sticks, dry throat and mouth, dryness of the intestine constipation.

Folium Mori: nature and flavor are sweet, bitter, cold.Return lung, Liver Channel.Dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving, is mainly used to anemopyretic cold, lung-heat type cough, dizziness headache, and conjunctival congestion is dim-sighted.

Radix Bupleuri: nature and flavor are bitter, are slightly cold.Return liver, gallbladder meridian.Reconciling superficies and interior, soothing the liver, yang invigorating, is mainly used to cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.

Massa Medicata Fermentata: nature and flavor sweet, acrid, warm.Be included into spleen, stomach warp.Invigorating the spleen and regulating the stomach, helps digestion in adjusting, cures mainly retention of food and drink, feeling of stuffiness in chest abdominal distention, vomiting dysentery, and postnatal blood stasis is suffered from abdominal pain, and children's's enlarged abdomen heavily fortified point is long-pending.

Fructus Alpiniae Oxyphyllae: nature and flavor are pungent, temperature.Be included into spleen, kidney channel.Warming the spleen, warming the kidney, solid and gas, arresting seminal emission, cure mainly cold air stomachache, invasion by pathogenic cold vomit and diarrhoea, many salivas, seminal emission, dribbling urination, night many urine.

Rhizoma Polygonati Odorati: nature and flavor are sweet, is slightly cold.Attach to the lung and stomach meridians.Nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst, be mainly used to lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.

Ramulus et Folium Rhinacanthi nasuti: nature and flavor are sweet, light is flat.Clearing away lung-heat to relieve cough, dampness removing is antipruritic, is mainly used to pulmonary tuberculosis early stage; Tinea corporis is controlled in external, eczema.

Bulbus Fritillariae Pallidiflorae: cold nature, bitter in the mouth, sweet.Return lung, heart channel.Lung moistening, reduce phlegm, eliminating stagnation.

Radix Panacis Quinquefolii: sweet, the micro-hardship of nature and flavor is cool.GUIXIN, lung, kidney channel.Boosting qi and nourishing yin, clearing away heat and promoting production of body fluid, be mainly used to deficiency of vital energy the moon and lose, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired of tired, quenches one's thirst, dryness of the mouth and throat.

Radix Ophiopogonis: nature and flavor are sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, and for dryness of the lung dry cough, chronic consumptive disease is coughed, and Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.

Mel: nature and flavor are sweet is flat.Return lung, spleen, large intestine channel.Invigorating middle warmer, moisturizes, pain relieving, removing toxic substances, for the empty pain of gastral cavity abdomen, and dryness of the lung dry cough, dryness of the intestine constipation; External treatment skin infection is not held back, burn due to hot liquid or fire.

In order to for lung treatment, present invention employs the medicine of multiple treatment pneumonopathy, specifically broken down as follows according to its function:

Lung heat clearing expels the heat-evil medicine: Herba Houttuyniae, Fructus Momordicae, Herba Fragariae nilerrensis, Bulbus Fritillariae Cirrhosae, Herba Glossogynes tenuifoliae, Radix Scutellariae, Herba Artemisiae Annuae.

Removing toxic substances and promoting pus discharge medicine: Radix heyneae trijugae, Adeps caprae seu ovis, Fructus Lycii, Radix Polygoni Multiflori, sky fourth, Mel.

Pungent cool medicine for promoting the dispersing of the lung: Semen Ginkgo, Radix Asparagi, Folium Mori.

Invigorating spleen to remove dampness medicine: Radix Bupleuri, Massa Medicata Fermentata, Fructus Alpiniae Oxyphyllae.

Except fraud emergency medicine: Rhizoma Polygonati Odorati.

Nourishing YIN and moistening the lung medicine: Ramulus et Folium Rhinacanthi nasuti, Bulbus Fritillariae Pallidiflorae, Radix Panacis Quinquefolii, Radix Ophiopogonis.

Wherein, the classification that pharmic function not divides according to it realizes, and such as Herba Houttuyniae can expel the heat-evil in lung heat clearing, also can assist for removing toxic substances and promoting pus discharge, pungent cool lung qi dispersing; Radix Panacis Quinquefolii gets final product nourishing YIN and moistening the lung, can assist again for pungent cool lung qi dispersing, except fraud emergency; Radix Ophiopogonis gets final product nourishing YIN and moistening the lung, can assist again and expel the heat-evil for lung heat clearing; Herba Fragariae nilerrensis can expel the heat-evil in lung heat clearing, can assist again for removing toxic substances; Fructus Lycii, except can be used for removing toxic substances, also can be assisted for expelling the heat-evil; Folium Mori get final product pungent cool lung qi dispersing, can assist for nourishing YIN and moistening the lung again, removing toxic substances; Mel can detoxify, and can assist for spleen invigorating again; Ramulus et Folium Rhinacanthi nasuti gets final product nourishing YIN and moistening the lung, can assist removing lung-heat again, and with certain Detoxication; In addition, Radix Bupleuri joins Radix Scutellariae, Herba Artemisiae Annuae, and three is the compatibility of the mutual-assistance, completing separately under its oneself effect prerequisite, can expel the heat-evil and complete Detoxication by expelling pathogenic factors from the exterior; Radix Asparagi and mutual reinforcement between Radix Ophiopogonis are use, can lung-yin nourishing, and lung moistening is dry, clearing away lung-heat, again can nourishing stomach-YIN, clearing away stomach-heat, promoting the production of body fluid to quench thirst.

The beneficial effect that technical scheme provided by the invention is brought is: Chinese medicine of the present invention has that lung heat clearing expels the heat-evil, removing toxic substances and promoting pus discharge, pungent cool lung qi dispersing, invigorating spleen to remove dampness, effect except fraud emergency, nourishing YIN and moistening the lung, releasing focus, remove the basic cause of disease, specific aim is stronger, drug effect is gone directly focus, the cooperation of pulling together of multi-medicament, indispensable, realize the effect for the treatment of both the principal and secondary aspects of a disease, evident in efficacy; Adopt Chinese crude drug, medicine source is abundant, safe and effective, inexpensive, not easily produces drug resistance, makes simple, convenient drug administration, and patient is easy to accept; Its curative effect is unique, thoroughly radical cure lung abscess.

Detailed description of the invention

A kind of Chinese medicine preparation for the treatment of pulmonary abscess provided by the invention, its concrete ingredient and preparation process are as described in the following Examples.

Embodiment 1:

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 12 parts, Fructus Momordicae 15 parts, Herba Fragariae nilerrensis 10 parts, Bulbus Fritillariae Cirrhosae 10 parts, Herba Glossogynes tenuifoliae 8 parts, Radix Scutellariae 16 parts, Herba Artemisiae Annuae 6 parts, Radix heyneae trijugae 1 part, Adeps caprae seu ovis 7 parts, Fructus Lycii 5 parts, Radix Polygoni Multiflori 10 part, day fourth 20 parts, Semen Ginkgo 3 parts, Radix Asparagi 20 parts, 10 parts, Folium Mori, Radix Bupleuri 10 parts, Massa Medicata Fermentata 18 parts, Fructus Alpiniae Oxyphyllae 26 parts, Rhizoma Polygonati Odorati 25 parts, Ramulus et Folium Rhinacanthi nasuti 12 parts, Bulbus Fritillariae Pallidiflorae 10 parts, Radix Panacis Quinquefolii 5 parts, Radix Ophiopogonis 25 parts, Mel 5 parts.

The dosage form of described Chinese medicine is pill, and its concrete preparation process is:

Step one: first by Fructus Momordicae, Herba Fragariae nilerrensis, Bulbus Fritillariae Cirrhosae, Herba Glossogynes tenuifoliae, Radix heyneae trijugae, Adeps caprae seu ovis, Fructus Lycii, Radix Polygoni Multiflori, sky fourth, Semen Ginkgo, Radix Asparagi, Ramulus et Folium Rhinacanthi nasuti, Bulbus Fritillariae Pallidiflorae, Radix Panacis Quinquefolii, mixing Radix Ophiopogonis, dry in 60 DEG C of environment, obtain powder after grinding, cross 90 mesh sieves;

Step 2: get the surplus stock medical material mixing except Mel again, add 55% soak with ethanol 3 hours, the heating extraction 3 times relative to mixture 4 times amount, each 50 minutes, merge three extracting solution, cross 110 mesh sieves after filter, when filtrate is evaporated to 75-80 DEG C, relative density is the extractum of 1.08-1.12, becomes component one;

Step 3: step 2 Chinese medicine slag is added 2 times amount water soaking 3 hours, once, extraction time is 50 minutes to heating extraction, and thickening filtration is extractum shape, is component two;

Step 4: said components one and component 2 two kinds of extractum are condensed into pasty state, add the powder that step one obtains, add Mel and be twisted into pill.

Embodiment 2:

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 22 parts, Fructus Momordicae 30 parts, Herba Fragariae nilerrensis 20 parts, Bulbus Fritillariae Cirrhosae 25 parts, Herba Glossogynes tenuifoliae 16 parts, Radix Scutellariae 25 parts, Herba Artemisiae Annuae 22 parts, Radix heyneae trijugae 10 parts, Adeps caprae seu ovis 19 parts, Fructus Lycii 25 parts, Radix Polygoni Multiflori 22 part, day fourth 35 parts, Semen Ginkgo 12 parts, Radix Asparagi 40 parts, 28 parts, Folium Mori, Radix Bupleuri 26 parts, Massa Medicata Fermentata 32 parts, Fructus Alpiniae Oxyphyllae 35 parts, Rhizoma Polygonati Odorati 32 parts, Ramulus et Folium Rhinacanthi nasuti 24 parts, Bulbus Fritillariae Pallidiflorae 28 parts, Radix Panacis Quinquefolii 20 parts, Radix Ophiopogonis 40 parts, Mel 15 parts.

The dosage form of described Chinese medicine also can be made into granule, and its concrete preparation process is:

Step one: described raw medicinal material is mixed in described ratio, cross 100 mesh sieves after grinding to form granule, be placed in and decoct marmite, add three times of water soakings of mixture weight, soak time is 30 minutes;

Step 2: be heated to boil, changes slow fire and boils 15 minutes, then isolate decoction liquor;

Step 3: after the water adding isolated medicinal residues weight three times repeats to boil, change slow fire and boil 15 minutes, then isolate decoction liquor;

Step 4: collect twice decoction liquor, centrifugalize, when being evaporated to 70-80 DEG C under vacuum 0.08-0.10Mpa, relative density is the mastic of 1.22-1.35, spraying dry, inlet temperature 100-110 DEG C, leaving air temp 90-95 DEG C of spray dryer, be ground into powder subsequently, make dried cream powder;

Step 5: the beta-schardinger dextrin-adding cane sugar powder relative to dried cream powder quality 0.4 ~ 0.6 times and 0.3 ~ 0.4 times in the dried cream powder obtained, makes granule, dry in 70 DEG C of environment, obtains granule.

Embodiment 3:

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 15 parts, Fructus Momordicae 16 parts, Herba Fragariae nilerrensis 12 parts, Bulbus Fritillariae Cirrhosae 15 parts, Herba Glossogynes tenuifoliae 10 parts, Radix Scutellariae 18 parts, Herba Artemisiae Annuae 10 parts, Radix heyneae trijugae 2 parts, Adeps caprae seu ovis 10 parts, Fructus Lycii 10 parts, Radix Polygoni Multiflori 12 part, day fourth 25 parts, Semen Ginkgo 5 parts, Radix Asparagi 25 parts, 12 parts, Folium Mori, Radix Bupleuri 12 parts, Massa Medicata Fermentata 22 parts, Fructus Alpiniae Oxyphyllae 28 parts, Rhizoma Polygonati Odorati 26 parts, Ramulus et Folium Rhinacanthi nasuti 15 parts, Bulbus Fritillariae Pallidiflorae 15 parts, Radix Panacis Quinquefolii 10 parts, Radix Ophiopogonis 28 parts, Mel 8 parts.

The dosage form of this Chinese medicine is pill, and its preparation method is with embodiment 1.

Embodiment 4:

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 20 parts, Fructus Momordicae 25 parts, Herba Fragariae nilerrensis 18 parts, Bulbus Fritillariae Cirrhosae 22 parts, Herba Glossogynes tenuifoliae 15 parts, Radix Scutellariae 23 parts, Herba Artemisiae Annuae 20 parts, Radix heyneae trijugae 6 parts, Adeps caprae seu ovis 15 parts, Fructus Lycii 20 parts, Radix Polygoni Multiflori 18 part, day fourth 32 parts, Semen Ginkgo 10 parts, Radix Asparagi 35 parts, 25 parts, Folium Mori, Radix Bupleuri 23 parts, Massa Medicata Fermentata 30 parts, Fructus Alpiniae Oxyphyllae 32 parts, Rhizoma Polygonati Odorati 30 parts, Ramulus et Folium Rhinacanthi nasuti 22 parts, Bulbus Fritillariae Pallidiflorae 25 parts, Radix Panacis Quinquefolii 15 parts, Radix Ophiopogonis 35 parts, Mel 12 parts.

The dosage form of this Chinese medicine is granule, and its preparation method is with embodiment 2.

Embodiment 5:

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 18 parts, Fructus Momordicae 20 parts, Herba Fragariae nilerrensis 15 parts, Bulbus Fritillariae Cirrhosae 20 parts, Herba Glossogynes tenuifoliae 12 parts, Radix Scutellariae 20 parts, Herba Artemisiae Annuae 15 parts, Radix heyneae trijugae 5 parts, Adeps caprae seu ovis 12 parts, Fructus Lycii 15 parts, Radix Polygoni Multiflori 15 part, day fourth 30 parts, Semen Ginkgo 8 parts, Radix Asparagi 30 parts, 20 parts, Folium Mori, Radix Bupleuri 15 parts, Massa Medicata Fermentata 25 parts, Fructus Alpiniae Oxyphyllae 30 parts, Rhizoma Polygonati Odorati 28 parts, Ramulus et Folium Rhinacanthi nasuti 20 parts, Bulbus Fritillariae Pallidiflorae 20 parts, Radix Panacis Quinquefolii 12 parts, Radix Ophiopogonis 30 parts, Mel 10 parts.

The dosage form of this Chinese medicine is pill, and its preparation method is with embodiment 1.

When said medicine is pill, be made into 0.3g every, when taking, every day 3 times, each 3, warm water takes, and every 12 days is a course for the treatment of; When using granules medicine of the present invention, after being made into the encapsulation of 0.4g/ bag, 3 times on the one, take for each 2 bags, every 12 days is a course for the treatment of, avoids ichthyophagy, shrimp, chicken and maror when taking medicine, anemia of pregnant woman's diet.

Toxicity test:

Acute toxicity test: application NIH mice 80, SPF level, 4 week age and 8 week age etc. count, and male and female half and half, body weight 11.16 ~ 24.16g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 40, i.e. matched group and administration group, fasting 12 hours before experiment; The pill prepared by embodiments of the invention 6 is water-soluble, and (concentration is 6.98g crude drug/ml, maximum concentration) gavage, gavage volume is 5.12ml/kg(and unit dosage form is 35.74 crude drugs/kg), matched group gives normal saline, administration in one day 2 times, delivery time 8 hours, Continuous Observation 15 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 15 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.

Mouse oral gavage pill solution of the present invention LD50>35.74 crude drug/kg, every day, maximum dosage-feeding was 59.35 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 5.60g crude drug/day/people, adult body weight in 60KG, average dosage is 0.093g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 18g) oral administration gavage Chinese medicine of the present invention is 638 times of quantity.

From result, all animals are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to mouse vagina and damaged skin, there are no irritative response and other untoward reaction.Toxicity test proves, the not toxic effect of this medicine and untoward reaction, clinical practice is safe and reliable

Long term toxicity test: the granule of the embodiment of the present invention 2 is pressed 5.60,23.35 and 35.74g crude drug/kg continuous use 20 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 20 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: be proven, after Jinan hospital adopts this Chinese medicine pill of my company development, in the 106 routine medical records of to provide follow-up care for a patient so far for 2010,20-30 year 16 example, 30-40 year 37 example, 40-50 year 31 example, more than 50 years old 22 examples, about 38 years old mean age, the ill course of disease between 3-12 month, after taking medicament of the present invention, cure 98 examples completely, basic healing 8 example, invalid 0 example, therapeutic effect is very good.

Model case:

Section so-and-so, man, 36 years old, sick send out initial stage cough, chest pain, dry cough, heating, after occur spitting blood, after going to Jinan hospital western medical treatment a period of time after clinic treats one week, acute symptom take a favorable turn, but fail all to eliminate, still there is cough, vomica, spit blood, be interrupted heating and chest pain etc., its expectoration amount is many, thickness, purulence, frowziness; Be diagnosed as pulmonary abscess sick mid-term by inspection, doctor trained in Western medicine adopts systemic drug treatment, comprises the application of antibiotic whole body and postural drainage, medicine, spraying and tracheascope suction sputum etc. are dripped in local, it is invalid after 20 days to treat, and doctor trained in Western medicine suggestion carries out operative treatment, because patient adheres to changing treatment by Chinese herbs into, after take transference cure after two courses for the treatment of of medicine of the present invention, its mental restoration, antisecosis, once in a while dry cough but without expectorant, after adhere to taking three courses for the treatment of of medicine of the present invention after fully recover, follow up a case by regular visits to so far without recurrence.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (8)

1. treat the preparation method of the Chinese medicine preparation of pulmonary abscess for one kind, it is characterized in that, comprise the raw medicinal material of following ratio of weight and number: Herba Houttuyniae, Fructus Momordicae, Herba Fragariae nilerrensis, Bulbus Fritillariae Cirrhosae, Herba Glossogynes tenuifoliae, Radix Scutellariae, Herba Artemisiae Annuae, Radix heyneae trijugae, Adeps caprae seu ovis, Fructus Lycii, Radix Polygoni Multiflori, sky fourth, Semen Ginkgo, Radix Asparagi, Folium Mori, Radix Bupleuri, Massa Medicata Fermentata, Fructus Alpiniae Oxyphyllae, Rhizoma Polygonati Odorati, Ramulus et Folium Rhinacanthi nasuti, Bulbus Fritillariae Pallidiflorae, Radix Panacis Quinquefolii, Radix Ophiopogonis, Mel;

The dosage form of described Chinese medicine is pill, and its concrete preparation process is:

Step one: first by Fructus Momordicae, Herba Fragariae nilerrensis, Bulbus Fritillariae Cirrhosae, Herba Glossogynes tenuifoliae, Radix heyneae trijugae, Adeps caprae seu ovis, Fructus Lycii, Radix Polygoni Multiflori, sky fourth, Semen Ginkgo, Radix Asparagi, Ramulus et Folium Rhinacanthi nasuti, Bulbus Fritillariae Pallidiflorae, Radix Panacis Quinquefolii, mixing Radix Ophiopogonis, dry in 50-70 DEG C of environment, obtain powder after grinding, cross 80-100 mesh sieve;

Step 2: get the surplus stock medical material mixing except Mel again, add 50-60% soak with ethanol 3 hours, the heating extraction 3 times relative to mixture 3-5 times amount, each 45-55 minute, merge three extracting solution, cross 100-120 mesh sieve after filter, when filtrate is evaporated to 75-80 DEG C, relative density is the extractum of 1.08-1.12, becomes component one;

Step 3: step 2 Chinese medicine slag is added 2-3 times amount water soaking 3 hours, once, extraction time is 45-55 minute to heating extraction, and thickening filtration is extractum shape, is component two;

Step 4: said components one and component 2 two kinds of extractum are condensed into pasty state, add the powder that step one obtains, add Mel and be twisted into pill.

2. the preparation method of the Chinese medicine preparation for the treatment of pulmonary abscess according to claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 12-22 part, Fructus Momordicae 15-30 part, Herba Fragariae nilerrensis 10-20 part, Bulbus Fritillariae Cirrhosae 10-25 part, Herba Glossogynes tenuifoliae 8-16 part, Radix Scutellariae 16-25 part, Herba Artemisiae Annuae 6-22 part, Radix heyneae trijugae 1-10 part, Adeps caprae seu ovis 7-19 part, Fructus Lycii 5-25 part, Radix Polygoni Multiflori 10-22 part, it fourth 20-35 part, Semen Ginkgo 3-12 part, Radix Asparagi 20-40 part, Folium Mori 10-28 part, Radix Bupleuri 10-26 part, Massa Medicata Fermentata 18-32 part, Fructus Alpiniae Oxyphyllae 26-35 part, Rhizoma Polygonati Odorati 25-32 part, Ramulus et Folium Rhinacanthi nasuti 12-24 part, Bulbus Fritillariae Pallidiflorae 10-28 part, Radix Panacis Quinquefolii 5-20 part, Radix Ophiopogonis 25-40 part, Mel 5-15 part.

3. the preparation method of the Chinese medicine preparation for the treatment of pulmonary abscess according to claim 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 15-20 part, Fructus Momordicae 16-25 part, Herba Fragariae nilerrensis 12-18 part, Bulbus Fritillariae Cirrhosae 15-22 part, Herba Glossogynes tenuifoliae 10-15 part, Radix Scutellariae 18-23 part, Herba Artemisiae Annuae 10-20 part, Radix heyneae trijugae 2-6 part, Adeps caprae seu ovis 10-15 part, Fructus Lycii 10-20 part, Radix Polygoni Multiflori 12-18 part, it fourth 25-32 part, Semen Ginkgo 5-10 part, Radix Asparagi 25-35 part, Folium Mori 12-25 part, Radix Bupleuri 12-23 part, Massa Medicata Fermentata 22-30 part, Fructus Alpiniae Oxyphyllae 28-32 part, Rhizoma Polygonati Odorati 26-30 part, Ramulus et Folium Rhinacanthi nasuti 15-22 part, Bulbus Fritillariae Pallidiflorae 15-25 part, Radix Panacis Quinquefolii 10-15 part, Radix Ophiopogonis 28-35 part, Mel 8-12 part.

4. the preparation method of the Chinese medicine preparation of the treatment pulmonary abscess according to Claims 2 or 3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 18 parts, Fructus Momordicae 20 parts, Herba Fragariae nilerrensis 15 parts, Bulbus Fritillariae Cirrhosae 20 parts, Herba Glossogynes tenuifoliae 12 parts, Radix Scutellariae 20 parts, Herba Artemisiae Annuae 15 parts, Radix heyneae trijugae 5 parts, Adeps caprae seu ovis 12 parts, Fructus Lycii 15 parts, Radix Polygoni Multiflori 15 parts, it fourth 30 parts, Semen Ginkgo 8 parts, Radix Asparagi 30 parts, 20 parts, Folium Mori, Radix Bupleuri 15 parts, Massa Medicata Fermentata 25 parts, Fructus Alpiniae Oxyphyllae 30 parts, Rhizoma Polygonati Odorati 28 parts, Ramulus et Folium Rhinacanthi nasuti 20 parts, Bulbus Fritillariae Pallidiflorae 20 parts, Radix Panacis Quinquefolii 12 parts, Radix Ophiopogonis 30 parts, Mel 10 parts.

5. the preparation method of the Chinese medicine preparation of the treatment pulmonary abscess according to above-mentioned arbitrary claim, is characterized in that, the powder after grinding in described step one crosses 90 mesh sieves, and the extracting solution in step 2 crosses 110 mesh sieves.

6. the preparation method of the Chinese medicine preparation of the treatment pulmonary abscess according to above-mentioned arbitrary claim, is characterized in that, the temperature in described step one is 60 DEG C.

7. the preparation method of the Chinese medicine preparation of the treatment pulmonary abscess according to above-mentioned arbitrary claim, is characterized in that, the ethanol mass percent in described step 2 is 55%.

8. the preparation method of the Chinese medicine preparation of the treatment pulmonary abscess according to above-mentioned arbitrary claim, is characterized in that, the time of at every turn extracting concentrated solution in described step 2 and step 3 is 50 minutes.