CN103041256A

CN103041256A - Chinese herb preparation for curing recurrent respiratory tract infection of children

Info

Publication number: CN103041256A
Application number: CN2012105942819A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Huaren Information Technology Development Co Ltd
Current assignee: CHONGQING XUANNU BIOTECHNOLOGY CO., LTD.
Priority date: 2012-12-31
Filing date: 2012-12-31
Publication date: 2013-04-17
Anticipated expiration: 2032-12-31
Also published as: CN103041256B

Abstract

The invention discloses a Chinese herb preparation for curing recurrent respiratory tract infection of children, which is prepared from the following raw materials: notopterygium root, fructus aurantii, roots of kudzu vine, rhizoma atractylodis, schizonepeta spike, periostracum cicada, poria cocos, astragalus mongholicus, radix angelicae, radix ophiopogonis, radices sileris, scutellaria baicalensis, rhizoma nardostachyos, rhizoma kaempferiae, asarum and dogwood. The Chinese herb preparation is specific to young bodies of children, is applied to diseases of abnormal body temperature change, exogenous pathogenic factors going in at a weak time, external infection and seasonal pathogenic factors, easily-caused heat transmission and repeated infection, adopts traditional Chinese medicinal materials of different drug properties for scientific compatibility of medicines, has strong antiviral performance, antipyretic and anti-inflammatory performance, and body immunity enhancement, is safe, has little toxic and side effect, is convenient to use, is short in curing time, and is less prone to recur after healing.

Description

A kind of Chinese medicine preparation for the treatment of infantile respiratory tract infection repeatedly

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, particularly a kind of Chinese medicine preparation for the treatment of infantile respiratory tract infection repeatedly.

Background technology

Infantile respiratory tract infection repeatedly is the common clinical frequently-occurring disease, RRTI is a kind of commonly encountered diseases, the frequently-occurring disease of paying attention to gradually for Chinese scholars in recent years, modern medicine thinks that definite pathogenesis still imperfectly understands, the result of many factors comprehensive function, one of major reason that immunologic hypofunction is considered to fall ill.

Theory of Chinese medical science is thought, feels again youngster's pathogeny crucial " and not many weakened body resistance in heresy ", in recent years to some extent development of this research, thinks RRTI system because of lung, spleen deficiency, and imbalance of YIN and YANG, Wei Yang are not solid.Western medicine can injure the tender body of child mostly, so Traditional Chinese medical theory is foundation, for the physique characteristic of the young sun of the young the moon of child, prescription is precise and appropriate, determined curative effect.The traditional Chinese medical science thinks that lung spleen deficiency of kidney-QI is the key of its morbidity, and " Plain Questions five is hidden and generated a piece of writing " said: " all gas persons all belong to lung." lung governing qi, department breathes, and the whole body mechanism of qi is had important regulating action.The insufficiency of vital energy and blood of lung is then defended QI-insufficiency, so spontaneous perspiration, easily diseases caused by exogenous pathogenic factor.Children's's the spleen tending to insufficiency usually, weakness of the spleen and stomach, the fortune of receiving is not normal, the biochemical weary source of QI and blood, inability of earth to generate metal, lung qi are also empty, are easy to diseases caused by exogenous pathogenic factor.Diseases caused by exogenous pathogenic factor repeatedly, prolonged illness is impairment of the kidney, and kidney is the root of Yuanyang, and it is not enough that deficiency of kidney-QI more causes the lung spleen.Form vicious cycle.This shows that the treatment primary disease should the lung benefiting strengthening spleen, tonifying kidney, benefiting QI for strengthening the superficies.Take QI invigorating as main, kidney qi is sufficient, the strong fortune of taste, and building up the spleen to supplement the lung then, the mutual generation between metal and water functional rehabilitation is normal.

Recurrent respiratory tract infection (RRTI) diagnostic criteria according in April, 1987 whole nation infantile respiratory disease academic conference revision: 0～2 years old age, 7 times/years of upper respiratory tract infection, 3 times/years of lower respiratory infections; 3～5 years old age, 6 times/years of upper respiratory tract infection, 2 times/years of lower respiratory infections; 6～14 years old age, 5 times/years of upper respiratory tract infection, 2 times/years of lower respiratory infections.The 2nd distance of upper respiratory tract infection the 1st time is more than at least 7 days.If the upper respiratory tract infection number of times is inadequate, can adds the lower respiratory infection number of times, otherwise then not become.Respiratory tract infection is one of modal disease of children's, especially is more common in winter-spring season.The Etiological that causes respiratory tract infection is virus, and minority is to be caused by antibacterial or mycoplasma pneumoniae.Light disease mainly is stream clear water nasal mucus, sneeze, slightly cough, pharyngalgia, tired, indigestion and loss of appetite, and low grade fever can be arranged, and the about 3-4 of the course of disease days, minority continued more than 1 week; Children with serious disease can accompany high heat, hacking cough, agitation, minority that hyperpyrexia convulsion can be arranged.Prognosis is generally good, but the weakling can cause the complication such as otitis media, cervical lymphadenitis, retropharyngeal abscess, and the only a few case can be led to viral myocarditis.Spread downwards such as inflammation and can cause bronchitis or pneumonia.Usually merging antibacterial on the basis of viral infection infects.Existing Therapeutic Method generally adopts antibiotherapy, and unrestrictedly drop simply so not only damages human body, strengthen treatment cost, when following infection fever, double again to use antibiotic, vicious cycle, cause the immunity disappearance, therapeutic effect also often can not be satisfactory.

Modern medicine is to the treatment of susceptible, how from zinc supplement, replenish the calcium, vitimin supplement, gamma globulin, thymosin, transfer factors etc. are to improve infant immunity.But indivedual body constitution are lacked immunotherapy targeted autoantibody, and effect is not ideal enough.With susceptible side's prophylactic treatment recurrent respiratory tract infection, the toxic and side effects of having avoided the long-term taking Western medicine to cause.So little in the urgent need to a toxic and side effects, curative effect is fast, be fit to children's's mouthfeel the Chinese medicine preparation of prophylactic treatment recurrent respiratory tract infection.

Summary of the invention

Infantile respiratory tract infection repeatedly is how not normal because of changes in temperature, and exopathogen is taken advantage of a weak point and sent out, and doctor trained in Western medicine is to the treatment of susceptible, how from zinc supplement, replenish the calcium, vitimin supplement, gamma globulin, thymosin, transfer factors etc. are to improve infant immunity.But indivedual body constitution are lacked immunotherapy targeted autoantibody, and effect is not ideal enough; For solving above-mentioned technical barrier, the invention provides a kind ofly take Traditional Chinese medical theory as foundation, for the physique characteristic of the young sun of the young the moon of child, prescription is precise and appropriate, determined curative effect, and medical material is common, the Chinese medicine preparation of the infantile respiratory tract infection repeatedly that preparation method is easy.

A kind of Chinese medicine preparation for the treatment of infantile respiratory tract infection repeatedly, the parts by weight of various raw materials are in its described preparation: 10～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Fructus Aurantiis, 10～15 parts of Radix Puerariaes, 10～15 parts of Rhizoma Atractylodis, 10～15 parts of Herba Schizonepetaes, 10～15 parts of Periostracum Cicadaes, 10～15 parts in Poria, 10～15 parts of the Radixs Astragali, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts of Radix Ophiopogonis, 10～15 parts of Radix Saposhnikoviaes, 10～15 parts of Radix Scutellariaes, 10～15 parts of Radix Et Rhizoma Nardostachyos, 10～15 parts of Rhizoma Kaempferiaes, 10～15 parts of Herba Asaris, 10～15 parts of Fructus Corni.

The parts by weight of various raw materials can be preferably in its described preparation: 10～12 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Fructus Aurantiis, 10～15 parts of Radix Puerariaes, 10～15 parts of Rhizoma Atractylodis, 10～15 parts of Herba Schizonepetaes, 10～15 parts of Periostracum Cicadaes, 10～12 parts in Poria, 10～12 parts of the Radixs Astragali, 10～15 parts of the Radixs Angelicae Dahuricae, 10～12 parts of Radix Ophiopogonis, 10～15 parts of Radix Saposhnikoviaes, 10～15 parts of Radix Scutellariaes, 10～12 parts of Radix Et Rhizoma Nardostachyos, 10～15 parts of Rhizoma Kaempferiaes, 10～15 parts of Herba Asaris, 10～15 parts of Fructus Corni.

The parts by weight of various raw materials can also be preferably in its described preparation: 12～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Fructus Aurantiis, 10～15 parts of Radix Puerariaes, 10～15 parts of Rhizoma Atractylodis, 10～15 parts of Herba Schizonepetaes, 12～15 parts of Periostracum Cicadaes, 12～15 parts in Poria, 10～15 parts of the Radixs Astragali, 12～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts of Radix Ophiopogonis, 12～15 parts of Radix Saposhnikoviaes, 10～15 parts of Radix Scutellariaes, 12～15 parts of Radix Et Rhizoma Nardostachyos, 10～15 parts of Rhizoma Kaempferiaes, 10～15 parts of Herba Asaris, 10～12 parts of Fructus Corni.

The ratio of weight and number of various raw materials can also be 10～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Fructus Aurantiis, 10～15 parts of Radix Puerariaes in the described preparation, 10～12 parts of Rhizoma Atractylodis, 10～12 parts of Herba Schizonepetaes, 10～15 parts of Periostracum Cicadaes, 10～15 parts in Poria, 10～15 parts of the Radixs Astragali, 10～15 parts of the Radixs Angelicae Dahuricae, 10～12 parts of Radix Ophiopogonis, 10～15 parts of Radix Saposhnikoviaes, 10～15 parts of Radix Scutellariaes, 10～15 parts of Radix Et Rhizoma Nardostachyos, 10～12 parts of Rhizoma Kaempferiaes, 10～15 parts of Herba Asaris, 10～12 parts of Fructus Corni.

The ratio of weight and number of various raw materials can also be 12～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Fructus Aurantiis, 12～15 parts of Radix Puerariaes in the described preparation, 12～15 parts of Rhizoma Atractylodis, 10～15 parts of Herba Schizonepetaes, 10～15 parts of Periostracum Cicadaes, 10～15 parts in Poria, 10～15 parts of the Radixs Astragali, 12～15 parts of the Radixs Angelicae Dahuricae, 12～15 parts of Radix Ophiopogonis, 10～15 parts of Radix Saposhnikoviaes, 10～15 parts of Radix Scutellariaes, 10～15 parts of Radix Et Rhizoma Nardostachyos, 10～15 parts of Rhizoma Kaempferiaes, 10～15 parts of Herba Asaris, 10～15 parts of Fructus Corni.

The ratio of weight and number of various raw materials can also be 10～12 parts of Rhizoma Et Radix Notopterygiis, 12～15 parts of Fructus Aurantiis, 10～15 parts of Radix Puerariaes in the described preparation, 10～15 parts of Rhizoma Atractylodis, 12～15 parts of Herba Schizonepetaes, 12～15 parts of Periostracum Cicadaes, 10～15 parts in Poria, 10～15 parts of the Radixs Astragali, 10～15 parts of the Radixs Angelicae Dahuricae, 10～12 parts of Radix Ophiopogonis, 10～15 parts of Radix Saposhnikoviaes, 10～15 parts of Radix Scutellariaes, 10～15 parts of Radix Et Rhizoma Nardostachyos, 10～12 parts of Rhizoma Kaempferiaes, 10～15 parts of Herba Asaris, 10～15 parts of Fructus Corni.

The ratio of weight and number of various raw materials can also be 12～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Fructus Aurantiis, 10～15 parts of Radix Puerariaes in the described preparation, 12～15 parts of Rhizoma Atractylodis, 12～15 parts of Herba Schizonepetaes, 10～15 parts of Periostracum Cicadaes, 10～15 parts in Poria, 10～15 parts of the Radixs Astragali, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts of Radix Ophiopogonis, 10～12 parts of Radix Saposhnikoviaes, 10～15 parts of Radix Scutellariaes, 10～12 parts of Radix Et Rhizoma Nardostachyos, 10～12 parts of Rhizoma Kaempferiaes, 10～15 parts of Herba Asaris, 10～12 parts of Fructus Corni.

The Chinese medicine preparation of described treatment infantile respiratory tract infection repeatedly, when infant companion laryngopharynx swelling and pain, the antiadoncus person adds 10～15 parts of Herba Taraxacis, 10～15 parts of Flos Loniceraes.

The Chinese medicine preparation of described treatment infantile respiratory tract infection repeatedly is when the infant hot hyperpyrexia person of occurring together adds 10～15 parts of Fructus Forsythiaes, 10～15 parts of Radix Isatidis.

The Chinese medicine preparation of described treatment infantile respiratory tract infection repeatedly is when infant companion poor appetite is not eaten, the person of eating without digesting adds 10～15 parts of Fructus Crataegis, 10～15 parts of Endothelium Corneum Gigeriae Galli.

The Chinese medicine preparation of described treatment infantile respiratory tract infection repeatedly, cough person adds 10～15 parts of the Radixs Stemonae, 10～15 parts of the Rhizoma Anemarrhenaes when infant companion abundant expectoration.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of infantile respiratory tract infection repeatedly, and the preparation process that described Chinese medicine preparation dosage form is oral solutions is:

A. get each the raw medicinal material selection except Herba Asari, Rhizoma Et Radix Notopterygii and Rhizoma Atractylodis, it is for subsequent use to make clean medical material;

B. get the clean medical material of respectively distinguishing the flavor of and decoct with water concentrating under reduced pressure three times;

C. with Herba Asari, Rhizoma Et Radix Notopterygii and Rhizoma Atractylodis extraction by steam distillation, get crystal

D. Herba Asari, Rhizoma Et Radix Notopterygii and Rhizoma Atractylodis crystal are put in the concentrated solution, added dextrin sterilizing patent medicine.

Among the described step b, each raw medicinal material that can get except Herba Asari, Rhizoma Et Radix Notopterygii and Rhizoma Atractylodis decocts with water three times, adds each time 5～10 times of water gagings, soaks, and decocts, and filters; 1.10～1.15 concentrated solution left standstill 24 hours when discarded medicinal residues, merging filtrate, reduction vaporization were concentrated into relative density and are 60～70 ℃, got supernatant and get final product.

In the described steps d, can sterilize with CO60 by concentrated solution, irradiation dose 8k adds dextrin, and then vacuum freezing seals and get final product.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of infantile respiratory tract infection repeatedly, and the preparation method that described Chinese medicine preparation dosage form is tablet comprises:

A, first Herba Asari, Rhizoma Et Radix Notopterygii are put into the boiler vapor distillation with Rhizoma Atractylodis and become quintessence oil;

B, get the surplus stock medicine again and put into water and soak, heat is extracted 2 times, becomes the extractum shape, is component 1;

C, medicinal residues ethanol extraction 1 time, thickening filtration are the extractum shape, are component 2;

D, above-mentioned two kinds of extractum are condensed into pasty state, pour in the quintessence oil that a step obtains, add the starch tabletting.

Among the described step b, can get crude drug and add heating extraction 2 times water soaking 1-2 hour that 5-10 doubly measures, each 1-2 hour, remove supernatant, merge extractive liquid,, the 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, 1.38 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, concentrated 30 minutes～45 minutes of heating is concentrated into the extractum shape, stand for standby use becomes component 1; Among the described step c, the medicinal residues that water extraction is crossed are put into 10 times of amount ethanol, heating and refluxing extraction 1 time, extraction time is 1～2 hour, the 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, 1.38 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, concentrated 30 minutes～45 minutes of heating is concentrated into the extractum shape, stand for standby use becomes component 2.

The present invention is directed to the tender body of children's, not normal to changes in temperature, exopathogen is taken advantage of a weak point and is sent out, the diseases caused by exogenous pathogenic factor seasonal pathogen is easy to heat-transformation, the disease of repeated infection, the present invention adopts the Chinese crude drug of different properties, has carried out the science compatibility, has stronger antiviral, antipyretic and anti-inflammatory, enhancing human body immunity effect; And safety, toxic and side effects is little, and is easy to use, and healing time is short, is difficult for recurrence after curing.The advantages such as compared with prior art teach, present technique has convenient drug administration, and medicament is easy to make, and is with low cost can be created preferably social value and economic interests.

The specific embodiment

Chinese medicine thinks that children's's internal organs are tender and lovely, and the skin hedge is not close, and it is solid to defend outer function, and cold warming up do not known self-regulated in addition, weather cataclysm during Chang Yinsi, and changes in temperature are not normal, and exopathogen is taken advantage of a weak point to send out and is primary disease; Because children's is " pure-yang constituent " " YANG often being in excess, YIN often being in shortage ", and the diseases caused by exogenous pathogenic factor seasonal pathogen is easy to heat-transformation, so clinical the most common with heat syndrome, bringing down a fever rapidly is its primary treatment purpose again.Upper respiratory tract infection is the department of pediatrics common frdquently encountered disease, account for 70%～80% of Pediatric Clinic amount, its clinical manifestation often has heating, nasal obstruction, watery nasal discharge, cough, expectoration and throat pain, other has part with symptom of digestive tract, as: inappetence, vomiting, diarrhoea, stomachache etc., its pathogenic microorganism is due to the virus more than 90%, and other still have the microorganisms such as antibacterial, mycoplasma.So, not only to give antiviral and antibiotic medicine in the treatment, also need preventing or arresting vomiting antidiarrheal, cough-relieving, reduce phlegm, the relevant medicine of facilitating digestion.

Recurrent respiratory tract infection belongs to Chinese medicine deficiency syndrome category, and the asthenia of pulmonosplenic qi of duty causes and disturbs in the asthenic fire and instability of surface.The table of lung master the whole body, The spleen and stomach provide the material basis of the acquired, source of generating QI and blood, the strong fortune of taste, QI and blood is vigorous, the capable bar of gas reaches, just can make the five internal organs peace and, all kinds of diseases and ailments are not given birth to.The primary disease sickness rate is higher, accounts for gop number more than 60%, and the traditional Chinese medical science thinks that primary disease is is main by ailment said due to cold or exposure, the caused outer perceptual disease of abnormal climates in four seasons.Because children's's internal organs are tender and lovely, skin is dredged thin, weakened defensive QI, then easily suffers from this disease, and young weak child Geng Yi suffers from, and has the change of disease after the morbidity rapidly easily repeatedly, and the characteristics such as the easy impairment of YIN of accompanied symptoms are arranged more.The high heat of infantile common cold, sheerly wind and cold or wind heat person are less, and in the majority with exogenous cold interior-heat or " heat wrapped by cold ".If the hot temperature of pure usefulness is dispersed, though exogenous cold is gone, and interior-heat is multiple vehement; The hot cool removing summer-heat of pure usefulness, then exogenous cold is loved, and interior-heat also gets nowhere.Facts have proved, cold with hot Wen Peixin, opening pores, clear thoroughly intrinsic heat; Be aided with the pivot ascending, draw heat and go out, assistant is with sour and sweet drugs can transforme into YIN, and battalion expels the heat-evil, and treating the location first where the pathogens havn’t intruded yet, can " Bi Qigong throws in one ".

Infantile respiratory tract infection repeatedly is the common clinical frequently-occurring disease, and the traditional Chinese medical science thinks that lung spleen deficiency of kidney-QI is the key of its morbidity, and " Plain Questions five is hidden and generated a piece of writing " said: " all gas persons all belong to lung." lung governing qi, department breathes, and the whole body mechanism of qi is had important regulating action.The insufficiency of vital energy and blood of lung is then defended QI-insufficiency, so spontaneous perspiration, easily diseases caused by exogenous pathogenic factor.Children's's the spleen tending to insufficiency usually, weakness of the spleen and stomach, the fortune of receiving is not normal, the biochemical weary source of QI and blood, inability of earth to generate metal, lung qi are also empty, are easy to diseases caused by exogenous pathogenic factor.Diseases caused by exogenous pathogenic factor repeatedly, prolonged illness is impairment of the kidney, and kidney is the root of Yuanyang, and it is not enough that deficiency of kidney-QI more causes the lung spleen.Form vicious cycle.This shows that the treatment primary disease should the lung benefiting strengthening spleen, tonifying kidney, benefiting QI for strengthening the superficies.Take QI invigorating as main, kidney qi is sufficient, the strong fortune of taste, building up the spleen to supplement the lung then, mutual generation between metal and water.

The prescription explanation: Radix Saposhnikoviae enters the sun, shaoyin channel in the side, is guiding drug; Rhizoma Et Radix Notopterygii warming the lung eliminating phlegm promoting the circulation of QI, the resolving mass and removing the obstruction of the collateral pain relieving; The detumescence of reducing phlegm and internal heat of Herba Schizonepetae, Periostracum Cicadae solution wind; The Herba Taraxaci reducing swelling and alleviating pain; The Radix Puerariae the lucid yang sending up reaches thoroughly; The spleen invigorating of Poria drying dampness to eliminate phlegm; Unclog and readjust lung qi; Rhizoma Anemarrhenae YIN nourishing and the production of body fluid promoting; The analgesic detoxification of Flos Lonicerae removing heat from blood; Periostracum Cicadae degerming toxin expelling; The Herba Asari repelling foulness with aromatics; Radix Astragali invigorating QI to consolidate the body surface resistance, the diuresis poison holding, invigorating the spleen and benefiting QI, the Radix Scutellariae pathogenic fire reducing relieves internal heat; The Endothelium Corneum Gigeriae Galli appetite-stimulating indigestion-relieving, the Radix Puerariae heat clearing away disappears tired, and Fructus Crataegi and Endothelium Corneum Gigeriae Galli strengthening the spleen to promote digestion are the treatment anorexia, the good medicine of food stagnation; Radix Isatidis, the Fructus Forsythiae solution antiperspirant that reduces phlegm and internal heat.Full side has heat-clearing and toxic substances removing, and function of spleen and stomach regulating, bar reach the merit of mechanism of qi.

The Radix Astragali is take tonify deficiency as main, can invigorating QI to consolidate the body surface resistance, and diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Be used for that insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst for a long time and do not hold back the person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of for a long time disunion.Modern medicine study shows that the Radix Astragali includes and multiple antibiotic effective ingredient, and the immunologic function of energy enhancing body, therefore can also be used for the generation of some infectious disease of prevention." book on Chinese herbal medicine meets former " carries: " Radix Astragali can all void of tonifying five ZANG-organs, controls the stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly then sends out, and has antiperspirant then to end." be the good medicine of promoting resistance and defence disease.Especially women's tonifying blood and regulating menstruation had good effect.

Radix Puerariae induces sweat and brings down a fever, and promotes the production of body fluid rash, yang invigorating antidiarrheal.Be used for fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, have loose bowels.Compendium of Material Medica is carried: Radix Puerariae, cool in nature, gas is put down, sweet in the mouth, tool heat clearing away, pathogenic fire reducing, all effects of toxin expelling.Modern medicine study shows: the isoflavonoid puerarin in the Radix Puerariae has certain curative effect to hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease.The elevate a turnable ladder yang-energy, light clear liter of the antidiarrheal of quenching the thirst Radix Puerariae fallen apart, and the property of medicine rises to be sent out, and willow is lifted yang-energy, and A healthy wind prevails to inspire body, and body fluid cloth is capable.Rise a clear positive air of taste and quench the thirst antidiarrheal dysentery.So be usually used in treating the interior-heat disease such as quench one's thirst.

Herba Schizonepetae is hot, tepor.Return lung, Liver Channel.The loose wind that induces sweat, rash.Be used for flu, headache, measles, rubella, skin infection from the beginning of.The parch to black treating hematochezia, metrorrhagia, puerperal blood faints.Horse Herba Schizonepetae one medicine is given birth to the effect that expelling pathogenic wind from the body surface is arranged, and parch to black then is used for hemostasis.Join Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, control wind and cold table disease; Join Flos Lonicerae, Fructus Forsythiae, Herba Menthae, control wind heat table disease; Join Gypsum Fibrosum, control headache due to pathogenic wind-heat; Join Fructus Arctii, Poria, Radix Glycyrrhizae, control laryngopharynx swelling and pain; Join charred Flos Sophorae, treating hematochezia; Join Rhizoma Imperatae, control epistaxis.Herba Schizonepetae and Folium Perillae all can relieving the exterior syndrome by diaphoresis, but Folium Perillae cold expelling power is strong, partially enters edema caused by disorder of QI, again can regulating the flow of QI to ease the stomach; And the Herba Schizonepetae power of dispeling the wind wins, and partially enters blood system, and parch to black can stop blooding again.So Folium Perillae commonly used in the side of regulating the flow of vital energy, and in the middle of blood-regulating prescription multiplex Herba Schizonepetae.

Periostracum Cicadae is sweet, and is cold.Return lung, Liver Channel.The function wind heat extraction that falls apart, sore-throat relieving, rash, nebula removing, spasmolytic.Be used for anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, conjunctival congestion cataracta, convulsion with spasms, tetanus.Be used for affection due to external wind and heat, fever with chills, cough, and the diseases such as rubella, skin pruritus.Periostracum Cicadae has the dispelling wind and heat pathogens effect, is used for wind heat table disease and often cooperates Herba Menthae to be equal to usefulness; The function that the rubella pruritus is also had dispelling wind for relieving itching.

Radix Saposhnikoviae acrid in the mouth, sweet, slightly warm in nature.Return bladder, liver, spleen channel.Expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.Cure mainly the diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus.Be used for headache due to common cold, the rubella pruritus.Control exterior syndrome due to wind-cold, headache general pain, aversion to wind and cold person, Chang Peiwu Herba Schizonepetae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis etc.; Control diseases caused by exogenous pathogenic factor rheumatism, the headache as wrap up in, heavy sensation of the body acroesthesia person, be equal to usefulness with Rhizoma Et Radix Notopterygii, Rhizoma Ligustici; Control the rubella pruritus, polygamy 5 Radix Sophorae Flavescentiss, Herba Schizonepetae, Radix Angelicae Sinensis etc.

Radix Isatidis clinically clearing away heat and cooling blood, antiviral antibacterial action is obvious, and consumption is large, can be rated as Chinese patent medicine.Result of study shows that Radix Isatidis has the internal energy pyrogen effect that causes fervescence of significant removing body." classification medical herbs " carries: " separate all malicious malignant boil, loose poison reduces internal heat." and cheap, toxic and side effects is little, is the good medicine of very popular heat-clearing and toxic substances removing.

Compendium of Material Medica is carried " Flos Lonicerae is good at removing toxic substances, so control carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating for the treatment of epidemic febrile disease, toxic-heat and blood stasis, the diseases such as carbuncle and ulcer.Modern pharmacological research shows, that Flos Lonicerae has is antibacterial, antiviral, antiinflammatory, analgesic, regulate the effect traditional Chinese medical science such as immunity and think, Flos Lonicerae is cold in nature, sweet in the mouth, gas are put down, and has the effect of heat-clearing and toxic substances removing, can treat the diseases such as pyretic toxicity abscess, carbuncle furuncle.And have the loose effect of a surname concurrently.The Flos Lonicerae antipyretic and antidote functions is quite strong, is product commonly used in surgery, the general sore and toxic that is used for having red and swollen heat pain,

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibiotic not worse than Rhizoma Coptidis, and does not develop immunity to drugs.Hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Fructus Forsythiae is bitter, is slightly cold.Return lung, the heart, small intestine meridian.Function is heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Be used for carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, high hot excessive thirst, coma is sent out speckle, the pyretic stranguria urine retention.The medicinal part of Fructus Forsythiae mainly is fruit.Its shell, i.e. " sticking up " in " a kind of reed mentioned in ancient books sticks up detoxifying pills ".Contain forsythol, coumarin, oleanolic acid, Saponin, Citrin etc.Have the effects such as heat clearing away, detoxifcation, eliminating stagnation evacuation of pus.Cure mainly warm, skin infection, scrofula, erysipelas, class's rash, influenza, be decocted in water for oral dose with fruit, or add in the prescription.Be usually used in anemopyretic cold.Nature,taste and action: Chinese medicine bitter in the mouth, cold nature.Heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.The mongolian medicine bitter in the mouth, cool in nature.Clearly " association's day ", antidiarrheal.Cure mainly: Chinese medicine is controlled calentura from the beginning of, anemopyretic cold, and heating is vexed, laryngopharynx swelling and pain, macule, erysipelas, scrofula, carbuncle pyogenic infections from tumour or sore, acute nephritis, pyretic stranguria.The mongolian medicine subcutaneous ulcer of harnessing the Yellow River, intestinal twinge, " association day " disease, intestinal heat.The Sheng Nong's herbal classic ": main cold and heat, Mus flaccidity, scrofula, carbuncle, malignant boil, goiter, stagnation of pathogenic heat, diseases due to noxious agents produced by various parasites.

The Radix Stemonae is sweet, bitter, tepor.Return lung meridian.Function cures mainly nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Be used for new chronic cough and cough pulmonary tuberculosis cough, pertussis; Nourishing the lung to arrest cough: be used for new chronic cough and cough, such as acute and chronic bronchitis, pertussis and pulmonary tuberculosis etc.Join Herba Ephedrae floss, Semen Armeniacae Amarum is controlled children's's wind and cold cough with asthma; Join Radix Asteris, Bulbus Fritillariae Uninbracteatae, Mirabilitum crystallina and control the infantile lung heat cough.

Fructus Crataegi, section is dried, and puts the large stir-fry of useing force in the pot and is degree, sprays clear water to outer wrinkly face brown, inner yellowish-brown, and taking-up is dried, and is Fructus Crataegi (parched to brown).Oral Fructus Crataegi can increase digestive enzyme, promotes decomposition and the digestion of fat, to because of eat meat or greasy too much due to distension and fullness in the abdomen, belch, anorexia, stomachache, diarrhoea person, curative effect is especially good.In addition, modern medicines tests shows that Fructus Crataegi has the slow and lasting effect that reduces blood pressure, but also cholesterol reducing and triglyceride, atherosclerosis, but but also the diastole coronary artery increases myocardial contraction, to arrhythmia.Therefore, be conducive to prevent and treat hypertension, hyperlipidemia, arteriosclerosis and coronary heart disease.

Endothelium Corneum Gigeriae Galli is sweet, and is cold.Return spleen, stomach, small intestinal, urinary bladder channel.Promoting digestion and invigorating the stomach, arresting seminal emission.Endothelium Corneum Gigeriae Galli contains gastric hormone, keratin, aminoacid and micro-pepsin, amylase etc.Behind the oral Endothelium Corneum Gigeriae Galli powder, the secretory volume of gastric juice, acidity and eupepsy all increase, and the stomach motion is strengthened, emptying quickening.Its acid extraction liquid or decoct can accelerate to get rid of radiostrontium from urine.

Poria is sweet, light, and is flat.GUIXIN, lung, spleen, kidney channel.The function promoting diuresis to eliminate damp pathogen, the spleen invigorating mind calming.Be used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, palpitation with fear insomnia.Eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Control dysuria, the edema distension, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful." herbal classic " carries it: " the contrary gas of the main breast side of body, melancholy is angerd frightened heresy and is probably throbbed with fear, knot pain under the heart, cold and heat stuffy sensation with restlessness, cough with dyspnea, mouthful burnt dry tongue, diuresis." " not Lu ": " only quenches one's thirst, likes to sleep, and large abdomen drenches drop, the disease due to obstruction of QI of middle-JIAO expectorant water, and edema is drenched knot.Open the breast internal organs, transfer visceral-qi, cut down the kidney heresy, long cloudy, physical strength profiting is during guarantor god keeps." " property of medicine opinion ": " appetizing, preventing or arresting vomiting is contrary, kind tranquilizing mind.Main consumptive lung disease expectorant is stopped up.Control pediatric epilepsy scared, trusted subordinate's distension, married woman's pyretic stranguria."

The Rhizoma Et Radix Notopterygii exterior cold of faling apart; Wind-damp dispelling; Sharp joint; Pain relieving.Main affection of exogenous wind-cold; It is lossless to have a headache; Mimeograph cold-damp numbness; The edema due to wind pathogen edema; Sore swollen toxin.Be used for impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness is suffered from a deficiency of the kidney and is done to breathe heavily Diarrhoea; The external curing vitiligo, alopecia areata.The cold expelling that induces sweat, expelling wind and dampness, pain relieving.Be used for affection of exogenous wind-cold, fever with aversion to cold, the cards such as headache general pain.This product has stronger dispersing wind-cold and analgesic effect.Normal and Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Herba Asari are equal to usefulness, such as Notoptreygium Decoction of Nine Ingredients." Japan hanako materia medica ": " control a wind cutting and gas, muscles and bones fist contraction, extremity are thin bad, and head revolves the red painful and fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times aqueous vapor of eyes, five kinds of strain and seven kinds of impairment, deficient cold air, joint ache, tonneau the five internal organs."

Radix Puerariae induces sweat and brings down a fever, and promotes the production of body fluid rash, yang invigorating antidiarrheal.Be used for fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, have loose bowels.Compendium of Material Medica is carried: Radix Puerariae, cool in nature, gas is put down, sweet in the mouth, tool heat clearing away, pathogenic fire reducing, all effects of toxin expelling.Modern medicine study shows: the isoflavonoid puerarin in the Radix Puerariae has certain curative effect to hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease.The famous physician's Li Shizhen (1518-1593 A.D.) of the Ming Dynasty has carried out systematic research to Radix Puerariae, think the stem, leaf, flower of Radix Puerariae, really, root all can be used as medicine.He is like this record in Compendium of Material Medica: " Pueraria lobota, property is sweet, hot, flat, nontoxic, cures mainly: quench one's thirst, high fever of the body, vomiting, all numbness, a cloudy gas is separated all poison ".

Rhizoma Atractylodis are drying damp and strengthening spleen, and expelling wind and cold makes eye bright.Be used for distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Main the spleen and stomach being stranded by dampness; The asthenia drowsiness; Born of the same parents' painful abdominal mass abdominal distention; Inappetence; Tell and have loose bowels; Phlegm retention; Damp-edema; The exterior syndrome folder is wet; Heavy sensation of the body pain; The arthromyodynia warm nature; Podomere is ached and is being weighed; The flaccidity folds in a garment.Be used for wet resistance taste, distension and fullness in the abdomen, the cold-damp leucorrhea, damp-warm diseases and damp invasion of lower energizer, foot swelling and pain in knee, flaccidity are soft unable.Controlling wet resistance taste, and seeing the thick disease such as turbid of distension and fullness in the abdomen, inappetence, fatigue and weakness, white and greasy fur, normal and the compatibility application such as Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae; Control the cold-damp leucorrhea, can join the Radix Angelicae Dahuricae with using.Such as damp and hot leucorrhea, can join the Rhizoma Anemarrhenae, Radix Sophorae Flavescentis, Radix Patriniae heterophyllae again; Damp invasion of lower energizer, foot swelling and pain in knee, flaccidity are soft unable, can join Cortex Phellodendri, Radix Achyranthis Bidentatae, Semen Coicis and be equal to usefulness; The hygropyrexia disease can be joined Gypsum Fibrosum, the Rhizoma Anemarrhenae is equal to usefulness.

The Radix Angelicae Dahuricae is hot, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping.Wind-damp dispelling, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving.Be used for headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus." detailed outline ": control nasal sinusitis, epistaxis, toothache, supraorbital bone pain, the large intestine constipation due to pathogenic wind, bleeding urine, married woman's blood dizziness due to wind pathogen fortune, regurgitation of food from the stomach is told food; Solution arsenic poison, snakebite, cutter arrow incised wound.

Radix Ophiopogonis YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Be used for dryness of the lung dry cough.The chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, the dryness of the intestine constipation; Pharyngeal diphtheria.Control dryness of the lung dry cough, spit blood, spitting of blood, consumptive lung disease, lung abscess, the asthenia dysphoria with smothery sensation is quenched one's thirst, and hinder in calentura Tianjin, dry mouth and throat, constipation." Mingyi Bielu ": treat the heavy sensation of the body icteric sclera, rami cardiaci inferiores is full, the asthenia exopathogenic heat, and the xerostomia excessive thirst, preventing or arresting vomiting is told, and the flaccidity of healing falls, and the reinforcing YIN-essence benefit is smart, during rapid digestion of food is transferred, protects god, decides lung qi, and settling five organs makes us fertile strong.

The Radix Et Rhizoma Nardostachyos promoting the circulation of QI to relieve pain, relieving stagnation and activating the spleen.External damp eliminating detumescence.Be used for burnt QI stagnated by cold, incoordination between the spleen and stomach, inappetence, vomiting; Toothache is controlled in external.Compendium of Material Medica: " Radix Et Rhizoma Nardostachyos, it is strongly fragrant that fragrance can be opened spleen, adds less in the taste medicine gas of very being amusing ".

Rhizoma Kaempferiae is called husky Rhizoma Zingiberis Recens, the mountain is peppery.Be used as medicine warming middle-JIAO for eliminating dampness, promoting the circulation of QI to relieve pain with rhizome.Cure mainly acute gastroenteritis, dyspepsia, cold syndrome of the stomach pain, toothache, rheumatic arthritis, traumatic injury.Bacteriostasis: the root decoct is all had in various degree inhibitory action to permitting 10 kinds of common pathomycetes such as Lan Shi trichophyton and Mongolian mutation thereof, homocentricity trichophyton, trichophyton in vitro.Nimbecetin has antiinflammation and Citrin activity to animal.Its effectiveness is similar to quercitrin, and than Kaempferitrin for poor.

Herba Asari dispels the wind, cold expelling, and row water is had one's ideas straightened out.Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.Effect to respiratory system: the tracheal smooth muscle that Herba Asari volatile oil causes convulsion to histamine or acetylcholine has the relexation of highly significant, and its antihistamine effect is strong than anti-acetylcholine. and the methyleugenol in the Herba Asari volatile oil has obvious relexation to guinea-pig isolated trachea. and in addition, these product have the effects such as antiinflammatory, immunosuppressant, local anesthesia.

The Fructus Corni liver and kidney tonifying is restrained astringent or styptic treatment for spontaneous sweating controlling nocturnal emission with astringent drugs reducing urination leukorrhagia stopping and is only collapsed hidroschesis and also have in addition promoting the production of body fluid to quench thirst.Be used for soreness of waist and knee joint dizziness and tinnitus, forgetful emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses menoxenia, profuse sweating collapse.Interior-heat is quenched one's thirst.Fructus Corni has another name called Fructus Corni, medicine Fructus Jujubae, real Fructus Jujubae, Fructus Corni, meat Fructus Jujubae etc., is China's rare Chinese medicine commonly used, and applicating history is long.It is gentle with its benefit power, tonifying YANG and do not help fire, YIN nourishing and oiliness diaphragm, convergence and do not stay the evil special efficacy that waits by successive dynasties usefulness that medical science is liked.Zhang Zhongjing has been formulated " JINGUI SHENQI WAN " take Fructus Corni as monarch.According to chemical analysis, Fructus Corni contains the effective ingredient such as the stronger cornin of physiologically active, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin, having and strengthen immunity, antiinflammatory, the pharmacological action such as antibiotic, is the Herba indigoferae Pseudotinctoriae of commonly using in the tcm clinical practice.

Gunpowder under the Anemarrhena heat clearing away cures mainly: epidemic febrile disease, high hot excessive thirst, cough and asthma, cough caused by dryness, constipation, osteopyrexia and fever, restlessness of asrhenia type and insomnia, the stranguria with turbid discharge of quenching one's thirst.Clearing away heat-fire promotes the production of body fluid and moisturizes.Clearing away heat-fire promotes the production of body fluid and moisturizes.Be used for fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, the dryness of the intestine constipation.Gypsum Fibrosum and the Rhizoma Anemarrhenae all can clearing away heat-fires, available treatment epidemic febrile disease excessive heat in QI system and the cough due to lung-heat card of etc.ing, but Gypsum Fibrosum is longer than clear pathogenic fire purging heat in the removing summer-heat, focuses on clearly eliminating the pathogens from the lung, excess of the stomach fire, lung-heat cough with asthma, the stomach-fire headache multiplex Gypsum Fibrosum of having a toothache; Be longer than in the Rhizoma Anemarrhenae pathogenic fire purging clear and rich, lung-heat type cough, interior-heat hectic fever due to YIN-deficiency, the multiselect Rhizoma Anemarrhenae of quenching one's thirst.

The Fructus Aurantii dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant and stagnate, the feeling of stuffiness in chest, the side of body is swollen, food stagnation, eructation, vomiting, heavy behind the dysentery, proctoptosis, uterine prolapse." Bencao Jingshu ": Fructus Aurantii, abnormal smells from the patient is led, and is generally identical with Fructus Aurantii Immaturus.But Fructus Aurantii Immaturus shape is little, and its gas is complete, and its property is strong, so kind assigning; Fructus Aurantii shape is large, and its gas is loose, and its property is slow, and Gu Qihang is slightly slow, be with able person's chest and diaphragm lung stomach minute and enter large intestine also.Its main air paralysis of itching, easing joint movement ends wind pain person, covers lung governing skin and hair, stomach master muscle, wind and cold wets in two warps, skin pruritus then, or have a pain, or numb, this medicine has hardship to let out hot loose merit, doublely can draw all wind medicines and enter two dirtyly, so required for controlling wind, ailment said due to cold or exposure is both loose, then joint nature tonneau.It treats the consumptive disease cough, the bored and listless person of back of the body arm, and lid also refers to that wind and cold is strongly fragrant in the part of the body cavity above the diaphragm housing the heart and lungs, then lung qi stagnates and is bored and listless cough.

Contain the multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in the Herba Taraxaci plant, the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting are arranged.Herba Taraxaci contains protein, fat, carbohydrate, trace element and vitamin etc. simultaneously, and abundant nutritive value is arranged, and is raw-eaten, stir-fry and eat, cook soup, is the plant of dietotherapeutic.The Dandelion Compositae belongs to herbaceos perennial.It is the plant of dietotherapeutic.According to the Compendium of Material Medica record, the flat sweet and slightly bitter taste of its property has heat-clearing and toxic substances removing, dispersing swelling and dissipating binds and galgctogogue action, and is very effective to the treatment mastitis.It is oral no matter to fry in shallow oil juice, or the smash to mud external application, and effect is all arranged.In addition, Herba Taraxaci also has the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting, is widely used in clinical.Compendium of Material Medica has a cloud: " the tender Seedling of Herba Taraxaci is edible, eats that to control infectious disease especially good raw." the successive dynasties Medical monographs such as Shennong's Herbal, Tang Materia Medica, " Chinese medicine voluminous dictionary " all give high evaluation.

Embodiment 1: the manufacturing process of the present invention's honey refining pill is: get Rhizoma Et Radix Notopterygii 1000g, Fructus Aurantii 1000g, Radix Puerariae 1000g, Rhizoma Atractylodis 1000g, Herba Schizonepetae 1000g, Periostracum Cicadae 1000g, Poria 1000g, Radix Astragali 1000g, Radix Angelicae Dahuricae 1000g, Radix Ophiopogonis 1000g, Radix Saposhnikoviae 1000g, Radix Scutellariae 1000g, Radix Et Rhizoma Nardostachyos 1000g, Rhizoma Kaempferiae 1000g, Herba Asari 1000g, Fructus Corni 1000g.Medical material was soaked 30 minutes to 1 hour, and heated and boiled 30 minutes is filtered filtrate for later use; Filtering residue adds water, and heating was boiled 30 minutes for the second time, refiltered filtrate for later use; Filtering residue adds water again, and heated and boiled is 30 minutes for the third time, filters; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 80 ℃, is cooled to Powdered being mixed in right amount with Mel after the oven dry and is twisted into slice; Pack take every 5g as a ball wax seal.

Embodiment 2: the present invention works as with laryngopharynx swelling and pain, and the manufacturing process of capsule is during the antiadoncus person: get Herba Taraxaci 1000g, Flos Lonicerae 1000g, Rhizoma Et Radix Notopterygii 1000g, Fructus Aurantii 1000g, Radix Puerariae 1000g, Rhizoma Atractylodis 1000g, Herba Schizonepetae 1000g, Periostracum Cicadae 1000g, Poria 1000g, Radix Astragali 1000g, Radix Angelicae Dahuricae 1000g, Radix Ophiopogonis 1000g, Radix Saposhnikoviae 1000g, Radix Scutellariae 1000g, Radix Et Rhizoma Nardostachyos 1000g, Rhizoma Kaempferiae 1000g, Herba Asari 1000g, Fructus Corni 1000g.Added water soaking 1-2 hour that 5-10 doubly measures, and extracted 2 times; Heating extraction 1-2 hour, be concentrated into the extractum shape, become component 1; The residue medicinal residues added the 60-90% soak with ethanol 24 hours, extracted twice, each 1 hour, merge extractive liquid, filters, and is concentrated, the 100-160 order filters, and the 6000-10000 rev/min of supernatant after centrifugal is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure relative density is the extractum of 1.35 (80 ℃), heating and refluxing extraction 2 times each 30 minutes～45 minutes, is extracted active ingredient, 2 extracting solution merging are settled into the extractum shape, as component 2.Above-mentioned two kinds of extractum concentrate dryings are become dried cream, co-grinding, it is an amount of to add starch, mixing, fill capsule.

Embodiment 3: the present invention occur together hot height when being fired into oral liquid preparation method be: Fructus Forsythiae 500g, Radix Isatidis 500g, Fructus Aurantii 500g, Radix Puerariae 1000g, Herba Schizonepetae 500g, Periostracum Cicadae 500g, Poria 500g, Radix Astragali 500g, Radix Angelicae Dahuricae 500g, Radix Ophiopogonis 500g, Radix Saposhnikoviae 500g, Radix Scutellariae 500g, Radix Et Rhizoma Nardostachyos 500g, Rhizoma Kaempferiae 500g, Fructus Corni 500g, each raw medicinal material of getting except Herba Asari, Rhizoma Et Radix Notopterygii and Rhizoma Atractylodis decocts with water three times, adds each time 5～10 times of water gagings, soak, decoct, filter; 1.10～1.15 concentrated solution left standstill 24 hours when discarded medicinal residues, merging filtrate, reduction vaporization were concentrated into relative density and are 60～70 ℃, got supernatant and get final product; With Herba Asari 500g, Rhizoma Et Radix Notopterygii 500g and Rhizoma Atractylodis 500g extraction by steam distillation, get crystal again; Herba Asari, Rhizoma Et Radix Notopterygii and Rhizoma Atractylodis crystal are put in the concentrated solution, added dextrin sterilizing patent medicine.Concentrated solution is sterilized with CO60, and irradiation dose 8k adds dextrin, and then vacuum freezing seals and get final product.

Embodiment 4: the present invention is when disease sees that poor appetite is not eaten, manufacturing process as tablet during the person of eating without digesting is: first Herba Asari 500g, Rhizoma Et Radix Notopterygii 500g put into the boiler vapor distillation with Rhizoma Atractylodis 500g and become quintessence oil; Get surplus stock medicine Fructus Forsythiae 500g, Radix Isatidis 500g, Fructus Aurantii 500g, Radix Puerariae 1000g, Herba Schizonepetae 500g, Periostracum Cicadae 500g, Poria 500g, Radix Astragali 500g, Radix Angelicae Dahuricae 500g, Radix Ophiopogonis 500g, Radix Saposhnikoviae 500g, Radix Scutellariae 500g, Radix Et Rhizoma Nardostachyos 500g, Rhizoma Kaempferiae 500g, Fructus Corni 500g, added heating extraction 2 times, each 1-2 hour water soaking 1-2 hour that 5-10 doubly measures, remove supernatant, merge extractive liquid,, the 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, 1.38 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, concentrated 30 minutes～45 minutes of heating is concentrated into the extractum shape, stand for standby use becomes component 1; The medicinal residues that water extraction is crossed are put into 10 times of amount ethanol, heating and refluxing extraction 1 time, extraction time is 1～2 hour, the 100-120 order filters, and is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams again, 1.38 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, concentrated 30 minutes～45 minutes of heating, be concentrated into the extractum shape, stand for standby use becomes component 2.Above-mentioned two kinds of component extractum concentrate dryings are become dried cream, co-grinding, it is an amount of to add starch, the mixing tabletting.

Embodiment 5: the preparation method of tablet was when method for making disease of the present invention was seen the abundant expectoration cough: get Radix Stemonae 500g, Rhizoma Anemarrhenae 500g, Fructus Aurantii 500g, Radix Puerariae 1000g, Herba Schizonepetae 500g, Periostracum Cicadae 500g, Poria 500g, Radix Astragali 500g, Radix Angelicae Dahuricae 500g, Radix Ophiopogonis 500g, Radix Saposhnikoviae 500g, Radix Scutellariae 500g, Radix Et Rhizoma Nardostachyos 500g, Rhizoma Kaempferiae 500g, Fructus Corni 500g, Herba Asari 500g, Rhizoma Et Radix Notopterygii 500g and Rhizoma Atractylodis 500, the weighting raw materials material is ground into granule, adds water, is heated to 30 ℃, warm macerating 1 hour, redistillation 1 hour, medicinal residues again adding distil water distill each 1 hour 2 times; To add 10% sodium chloride after three distillates mixing, cold preservation divides and gets the supernatant, adds 4 times of amount beta-schardinger dextrin-s, and suitable quantity of water adds cyclodextrin clathrate, starch, mix homogeneously, and tabletting is used film coating liquid again, carries out coating, namely gets tablet.

Pharmacology's toxicity test

1, acute toxicity test

The application mice carries out acute toxicity testing and shows: the Traditional Chinese medicine preparation capsule agent of the present invention of mice oral administration gavage, under 346.2g crude drug/kg dosage, the light activity minimizing appears in mice after the administration, recover normal about 1 hour, Continuous Observation is 7 days after the administration, none animal dead, its overall health of patients, diet, to take the photograph water, urine and body weight gain all normal, and experimental result shows: the maximum dosage-feeding of mice oral administration gavage Traditional Chinese medicine preparation capsule agent of the present invention is 346.2g crude drug/kg/d (LD50＞346.2g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; Press weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 3462 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

2, long term toxicity test

Select the SD rat, give variable concentrations (18.0,6.0, the Chinese medicine preparation pill of the present invention of 2.0g crude drug/kg), every day gavage once, continuous 90 days, 24 hours each groups are lived and are killed 1/2 animal (male and female half and half) after the last administration, live extremely after all the other 1/2 animals continuation observed for 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, after the administration 90 days and carry out hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) in 2 weeks of drug withdrawal and the index checkings such as blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain all change without unusual; Three dosage groups and matched group hematological examination, blood biochemical are learned, the urine biochemical analysis is all in normal range, between group without significant difference; Each is organized the main organs histopathological examination and shows no obvious abnormalities.The These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test Chinese medicine preparation of the present invention high, medium and low three dosage (18.0,6.0, the 2.0g crude drug/kg) administration in continuous 90 days has no significant effect rat, without clear and definite toxicity target organ and sensitive indicator, the convalescent period observation also has no the retardance toxic reaction, points out the dosage safety of Chinese medicine preparation clinical practice of the present invention higher.

3, select the SD rat, give variable concentrations (18.0,6.0, the Chinese medicine preparation of the present invention of 2.0g crude drug/kg), every day gavage once, continuous 90 days, 24 hours each groups are lived and are killed 1/2 animal (male and female half and half) after the last administration, live extremely after all the other 1/2 animals continuation observed for 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, after the administration 90 days and carry out hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) in 2 weeks of drug withdrawal and the index checkings such as blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain all change without unusual; Three dosage groups and matched group hematological examination, blood biochemical are learned, the urine biochemical analysis is all in normal range, between group without significant difference; Each is organized the main organs histopathological examination and shows no obvious abnormalities.The These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test Chinese medicine preparation of the present invention high, medium and low three dosage (18.0,6.0, the 2.0g crude drug/kg) administration in continuous 90 days has no significant effect rat, without clear and definite toxicity target organ and sensitive indicator, the convalescent period observation also has no the retardance toxic reaction, points out the dosage safety of Chinese medicine preparation clinical practice of the present invention higher.

Pharmacological effect experiment of the present invention:

The experimentation of antipyretic effect of the present invention

(1), experiment material:

1, animal: health large ear rabbit, body weight (2.4 ± 0.3) kg, male and female have concurrently.Shandong agricultural college provides.

2, medicine: medicine A: according to the Chinese medicine preparation (A1 organizes the honey refining pill that is respectively the embodiment of the invention 1 ~ embodiment 5 preparations to the A5 group, capsule, oral solutions, tablet, tablet Chinese medicine preparation) of method preparation of the present invention.

Medicine B: according to " Antifebrile oral liquor " the above method preparation.

Medicine C: according to " osmanthus fiber crops bavin antipyretic granule agent and production technology " the above technique preparation.

3, instrument: computer numeral clinical thermometer.

(2), experimental technique: get 24 of health large ear rabbits, 3d before the experiment is 55%-65% at room temperature 22-25 ℃, humidity, and every interval was surveyed animal anus temperature in 1 hour 1 time totally 4 times under the ventilated environment, animal is adapted to, and select the animal of body temperature fluctuation range in 0.4 ℃ of scope for subsequent use.During experiment animal is divided into 4 groups at random by the body weight size, is respectively normal saline group, A group, B group, C group.Survey rabbit anus temperature 1 time every 30min with the computer digital clinical thermometer, survey altogether 3 times, ask for its meansigma methods and be this animal basal body temperature.Press 1ml/kg administration rabbit ear edge intravenous injection deactivation escherichia coli pyrogenicity, and before pyrogenicity 30 minutes gastric infusions at twice after 30min and the pyrogenicity.After pyrogenicity 30,60,120,240 and 360min survey respectively rabbit anus temperature 5 times, calculate the difference respectively organize anus temperature and basal body temperature after the treatment of rabbit day part, processing takes statistics.

(3), experimental result: the results detailed in Table 1.

Different period body temperature situations of change after each treated animal treatment of table 1

(4), conclusion: as can be seen from Table 1, the result shows that the A group has obvious antipyretic effect to escherichia coli pyrogenicity rabbit, and its effect of bringing down a fever is better than B group and C group, and antipyretic effect is lasting than B group and C group.

Upper its clinical manifestation of sense of children's is: has some inkling of a cold, or delays a few days, and slight chill stream, lossless, or sweating is not saturating, and the neck body is scorching hot, hands and feet coolness, sleepy or dysphoria, red lip, xerostomia is thought drink, thin white fur of tongue or little Huang, the floating and tense pulse number, the stricture of vagina red tape is purple.The high heat of infantile common cold, sheerly wind and cold or wind heat person are less, and in the majority with exogenous cold interior-heat or " heat wrapped by cold ".If the hot temperature of pure usefulness is dispersed, though exogenous cold is gone, and interior-heat is multiple vehement; The hot cool removing summer-heat of pure usefulness, then exogenous cold is loved, and interior-heat also gets nowhere.Facts have proved, cold with hot Wen Peixin, opening pores, clear thoroughly intrinsic heat; Be aided with the pivot ascending, draw heat and go out, assistant is with sour and sweet drugs can transforme into YIN, and battalion expels the heat-evil, and treating the location first where the pathogens havn’t intruded yet, can " Bi Qigong throws in one ".

1 clinical data

With reference to the diagnostic criteria of recurrent respiratory tract infection, 160 routine recurrent respiratory tract infection (RRT I) infant is divided into 2 groups at random by examining time sequencing.Treatment group 80 examples, male 38 examples, women 42 examples; Age 1-2 year 50 examples, 2.1 years old-5 years old 23 examples, 5.1-7 year 7 examples.Matched group 80 examples, male 41 examples, women 39 examples; Age 1-2 year 48 examples, 2.1-5 year 21 examples.5.1-7 year old 11 examples. two groups are at aspects such as age, sexes relatively, no significant difference.

2 Therapeutic Method

Routine gives infection and symptomatic treatment between the matched group period of disease.Thymosin 5mg:, add the 10%GS50ml intravenous drip, once a day.Upper respiratory tract infection medication 3-7 days, bronchitis, 2 weeks of pneumonia medication.The same matched group for the treatment of group period of disease conventional therapy is without thymosin.After stable disease, give Chinese medicine susceptible side: Rhizoma Et Radix Notopterygii, Fructus Aurantii, Radix Puerariae, Rhizoma Atractylodis, Herba Schizonepetae, Periostracum Cicadae, Poria, the Radix Astragali, the Radix Angelicae Dahuricae, Radix Ophiopogonis, Radix Saposhnikoviae, Radix Scutellariae, Radix Et Rhizoma Nardostachyos, Rhizoma Kaempferiae, Herba Asari, Fructus Corni.When infant companion laryngopharynx swelling and pain, the antiadoncus person adds Herba Taraxaci, Flos Lonicerae.When the infant hot hyperpyrexia person of occurring together adds Fructus Forsythiae, Radix Isatidis.When infant companion poor appetite is not eaten, the person of eating without digesting adds Fructus Crataegi, Endothelium Corneum Gigeriae Galli.Cough person adds the Radix Stemonae, the Rhizoma Anemarrhenae when infant companion abundant expectoration.Be decocted in water for oral dose 1 dose of every day, took altogether for 3 weeks.Period in a medicine continues infection and symptomatic treatment as suffering from respiratory tract infection.

3 criterions of therapeutical effect and therapeutic outcome

The criterion of therapeutical effect produce effects: respiratory tract infection or only respiratory tract infection 1 time do not occur June in drug withdrawal; Effectively: the respiratory tract infection number of times reduces or does not reduce, but each infection symptoms is front light, and the course of disease shortens; Invalid: the respiratory tract infection number of times is treated front unchanged.

2 groups of curative effects of therapeutic outcome relatively see Table 1.

Compare p＜0.01 with matched group

Physical data

58 routine infants of clinical observation of the present invention all meet the diagnostic criteria of the infantile respiratory tract infection repeatedly of national infantile respiratory disease Chengdu meeting formulation in 1987.Male 35 examples wherein, women 23 examples; 2～12 years old age; The course of disease is equal more than 1 year.All selected infants all except PID and use the infant of immunosuppressant because of other diseases (such as nephritis).

Therapeutic Method

Adopt Chinese medicinal formulae: Rhizoma Et Radix Notopterygii, Fructus Aurantii, Radix Puerariae, Rhizoma Atractylodis, Herba Schizonepetae, Periostracum Cicadae, Poria, the Radix Astragali, the Radix Angelicae Dahuricae, Radix Ophiopogonis, Radix Saposhnikoviae, Radix Scutellariae, Radix Et Rhizoma Nardostachyos, Rhizoma Kaempferiae, Herba Asari, Fructus Corni.

When infant companion laryngopharynx swelling and pain, the antiadoncus person adds Herba Taraxaci, Flos Lonicerae.

When the infant hot hyperpyrexia person of occurring together adds Fructus Forsythiae, Radix Isatidis.

When infant companion poor appetite is not eaten, the person of eating without digesting adds Fructus Crataegi, Endothelium Corneum Gigeriae Galli.

Cough person adds the Radix Stemonae, the Rhizoma Anemarrhenae when infant companion abundant expectoration.Pulverization is taken for 2 times every day.≤ 7 years old each 2g of person,〉8 years old each 3g of person, 1 month is 1 course for the treatment of.All look into venous blood IgA, IgG, IgM and t lymphocyte subset group (CD3+, CD4+, and CD8+) before and after the treatment.Per 2 all further consultations are 1 time during the medication, and check 1 every day after the drug withdrawal, until 3 months.

Therapeutic outcome

Curative effect determinate standard: produce effects: respiratory tract infection does not occur in half a year in medication; Effectively: compared with the same period of last year the number of times that medication internal respiration half a year road infects shows effect and reduces 1～2 time, and the course of disease shortens; Invalid: attack times and the state of an illness are all without obviously improving.58 routine infant produce effects 36 examples as a result, effective 16 examples, invalid 6 examples, total effective rate 89.7%.The variation of immune indexes sees Table 1 before and after the treatment.

Immune indexes changes relatively before and after table 1 treatment

Immune indexes	Before the treatment	After the treatment
			IgG(g/L)	6.12±0.14	7.89±0.19
IgA(g/L)	5.16±0.46	9.87±0.26
			IgM(g/L)	0.97±0.14	1.23±0.27
CD3+(%)	40.1±1.7	56.9±1.6
			CD4+(%)	24.4±1.6	33.7±1.8
CD8+(%)	20.4±1.9	24.6±1.2

Immune indexes IgA, IgG, IgM, the CD3+ of infant after the treatment, CD4+, and CD8+ all increase before the treatment, and compare before the treatment, there were significant differences (P＜0.05).

Discuss

The pathogeny of infantile respiratory tract infection repeatedly is comparatively complicated, and relevant with many factors, it is closely related with the hypofunction of body fluid and cellular immunization that many researchs are thought.Use Abwehrkraft des Koepers and immunologic function that this Chinese medicinal formulae can improve infant.Radix Astragali benefiting QI for strengthening the superficies in the side and real defending, the Poria invigorating the spleen and benefiting QI, Papillary makes the prosperous table of gas real, and antiperspirant does not leak, and invades in heresy is also difficult; Radix Saposhnikoviae walks to show eliminating evil, and imperial ailment said due to cold or exposure; But add Radix Puerariae and Fructus Aurantii invigorating the spleen and benefiting QI and kidney.According to above observation, so the every immune indexes of this prescription Effective Raise is evident in efficacy for infantile respiratory tract infection repeatedly.

Embodiment 1: the Qin, man, 4 years old, first visit on July 5 in 2010.Mother's readme return home of travelling outdoors April, open wide the automobile window in the way, sleep soundly and catch cold, that night is with sending out the hot body temperature high 39.5 ℃, selects antibiotics, the Western medicine of bringing down a fever, height moves back (not being lower than all the time 38 ℃) when hot, but soon knock-on, recurrent respiratory tract infection 2 months, Western medicine has been used a lot, do not effect a permanent cure, require to use treatment by Chinese herbs.Examine quarter: 38 ℃ of body temperature, and spiritual beach wormwood wastes, and whole body is lossless, and neck, body are scorching hot, and brothers are cold, the throat hypodynia, xerostomia is thought drink, poor appetite, constipation with dry stool, yellow urine is few, and tongue is partially red, yellow and thin fur, floating and rapid pulse.Give we: Rhizoma Et Radix Notopterygii 7g, Fructus Aurantii 10g, Radix Puerariae 10g, Rhizoma Atractylodis 5g, Herba Schizonepetae 7g, Periostracum Cicadae 9g, Poria 10g, Radix Astragali 10g, Radix Angelicae Dahuricae 6g, Radix Ophiopogonis 10g, Radix Saposhnikoviae 7g, Radix Scutellariae 8g, Radix Et Rhizoma Nardostachyos 9g, Rhizoma Kaempferiae 7g, Herba Asari 8g, Fructus Corni 6g, Fructus Forsythiae 8g, Radix Isatidis 9g.Inactive all Western medicine take 7 days courses for the treatment of, make pill.Begin slight sweating, a fever of the body subtracts, and brothers turn temperature, and two is just unobstructed logical without hindrance, and spirit is slightly shaken, and body temperature is down to 37.5 ℃; Continuous take a course for the treatment of, body temperature is normal, spiritual amelioration, pharyngalgia is ended, lip profit mouthful and, know hungry rope food.A week is observed in drug withdrawal, and rehabilitation as before.Follow up a case by regular visits to half a year without recurrence.

Embodiment 2: Pan, and the woman, 5 years old, the head of a family stated at kindergarten and infects flu, and the infant cough is more than, and is medical after more than 14 days, intermittently still cough, and flu; The first quarter moon cause flu of suffering from cold is drawn cough, watery nasal discharge, and then dyspnea with rapid and short breath, heating, it is medical scorching for Zhi Suoguan once arrive his institute, take Western medicine heat and move back asthma and slightly subtract, but cough is more than, has expectorant to be difficult for bringing up, and coughs night heavily, is paroxysmal, and the companion vomits sputum or food.Receive can, large dry stool, urine is many.Disease see spirit still can, watery nasal discharge, pharynx is red and swollen large, colour of the tongue is little red, greasy in the yellow fur, fingerprint is purple.Disease belongs to the cough due to common cold, in have damp and hotly, the side uses: Rhizoma Et Radix Notopterygii 7g, Fructus Aurantii 6g, Radix Puerariae 8g, Rhizoma Atractylodis 6g, Herba Schizonepetae 8g, Periostracum Cicadae 8g, Poria 10g, Radix Astragali 10g, Radix Angelicae Dahuricae 6g, Radix Ophiopogonis 10g, Radix Saposhnikoviae 7g, Radix Scutellariae 8g, Radix Et Rhizoma Nardostachyos 9g, Rhizoma Kaempferiae 7g, Herba Asari 8g, Fructus Corni 6g, Radix Stemonae 5g, Rhizoma Anemarrhenae 6g.Inactive all Western medicine are made electuary with the present invention and are taken, and each 1 bag three times on the one, takes 7 days courses for the treatment of, begin slight sweating, a fever of the body subtracts, and brothers turn temperature, and two is just unobstructed logical without hindrance, and spirit is slightly shaken, body temperature are normal after 2 weeks, spiritual amelioration, pharyngalgia is ended, lip profit mouthful and, know hungry rope food.A week is observed in drug withdrawal, and rehabilitation as before.Follow up a case by regular visits to half a year without recurrence.

Embodiment 3: the land, and 3 years old, the man, kindergarten infects week of flu in head of a family's readme, selects antibiotics, the Western medicine of bringing down a fever, highly move back when hot, recurrent cough 2 months, cough syrup, Western medicine have been used and have much been loseed recovery from illness, require to use treatment by Chinese herbs.Examine quarter: 38 ℃ of body temperature, and spiritual beach wormwood wastes, and whole body is lossless, and neck, body are scorching hot, the throat hypodynia, dysphagia is had a medical check-up and seen antiadoncus, and is hoarse in a minute, tears sound.The side uses: Rhizoma Et Radix Notopterygii 6g, Fructus Aurantii 6g, Radix Puerariae 8g, Rhizoma Atractylodis 5g, Herba Schizonepetae 8g, Periostracum Cicadae 8g, Poria 10g, Radix Astragali 10g, Radix Angelicae Dahuricae 6g, Radix Ophiopogonis 8g, Radix Saposhnikoviae 7g, Radix Scutellariae 8g, Radix Et Rhizoma Nardostachyos 5g, Rhizoma Kaempferiae 7g, Herba Asari 8g, Fructus Corni 6g, Herba Taraxaci 9g, Flos Lonicerae 10g, all Western medicine of stopping using are taken granulation agent of the present invention, each 1 bag, three times on the one, take 7 days courses for the treatment of, a beginning fever of the body subtracts, and brothers turn temperature, two is just unobstructed logical without hindrance, and spirit is slightly shaken, and pharyngalgia is ended, lip profit mouthful and, the sound of speaking begins normally; Continue to use a course for the treatment of, body temperature is normal, spiritual amelioration, and the throat enlargement is fully good, and tonsil is no longer painful.A week is observed in drug withdrawal, and rehabilitation as before.Follow up a case by regular visits to half a year without recurrence.

Embodiment 4: turn round and look at certain, and the woman, 5 years old, the head of a family caught a cold when stating and having a bath to her, and cat fever is the week more than one, the transfusion rear infant anorexia of having an injection, food is received and is not changed.Sometimes readme stomachache is hard and dry.Medical after more than 10 days, intermittently still cough.Disease see spirit still can, watery nasal discharge, colour of the tongue is little red, and is greasy in the yellow fur, fingerprint is purple.The side uses: Rhizoma Et Radix Notopterygii 5g, Fructus Aurantii 6g, Radix Puerariae 8g, Rhizoma Atractylodis 6g, Herba Schizonepetae 8g, Periostracum Cicadae 8g, Poria 10g, Radix Astragali 6g, Radix Angelicae Dahuricae 6g, Radix Ophiopogonis 10g, Radix Saposhnikoviae 7g, Radix Scutellariae 8g, Radix Et Rhizoma Nardostachyos 9g, Rhizoma Kaempferiae 7g, Herba Asari 8g, Fructus Corni 6g, Radix Stemonae 5g, Rhizoma Anemarrhenae 6g, Fructus Crataegi 9g, Endothelium Corneum Gigeriae Galli 8g.Make tablet.All Western medicine of stopping using, each 2, three times on the one, take 7 days courses for the treatment of, body temperature is normal, spirit is slightly shaken, cough ends, lip profit mouthful and, know hungry rope food, two is just unobstructed logical without hindrance.Continue to take a course for the treatment of, return to one's perfect health, diet is normal.Follow up a case by regular visits to half a year without recurrence.

Embodiment 5: the side certain, 4 years old, head of a family's readme was since recurrent cough more than two years old, flu, pneumonia, tracheitis etc.Just can cure after all will adding transfusion with the antibiotic medicine, almost just the recurrent cough is sick again for every two weeks at every turn, carries case history and shows: JIUYUE in 2011 cough on the 15th, cough on October 13rd, 2011, on October 28th, 2011 bronchitis, December in 2011 tracheitis on the 5th, December in 2011 flu on the 24th, on January 10th, 2012 viral influenza, on February 9th, 2012 pneumonia tonsil two degree inflammation, on March 15th, 2012 flu, cough, on April 6th, 2012, flu was coughed.Child's body constitution is poor, emaciation and sallow complexion.The side uses: Rhizoma Et Radix Notopterygii 5g, Fructus Aurantii 6g, Radix Puerariae 8g, Rhizoma Atractylodis 6g, Herba Schizonepetae 8g, Periostracum Cicadae 8g, Poria 10g, Radix Astragali 6g, Radix Angelicae Dahuricae 6g, Radix Ophiopogonis 8g, Radix Saposhnikoviae 7g, Radix Scutellariae 8g, Radix Et Rhizoma Nardostachyos 9g, Rhizoma Kaempferiae 7g, Herba Asari 6g, Fructus Corni 7g, granulation agent, every day three times, each bag.Nurse one's health a week, begin slight sweating, a fever of the body subtracts, and brothers turn temperature, and two is just unobstructed logical without hindrance, and spirit is slightly shaken, and body temperature is normal, begins to add in the normal prescription Radix Stemonae 6g, Rhizoma Anemarrhenae 7g.Serve on 2 weeks.The cough beginning takes a turn for the better gradually, continues to use 2 weeks, and bronchitis begins to disappear.Continue to use the basic prescription of the present invention, begin to add Fructus Crataegi 9g, Endothelium Corneum Gigeriae Galli 8g, child's diet begin normally, lip profit mouthful and, know hungry rope food, two just unobstructed lead to without hindrance.Continued to take one month, and returned to one's perfect health, diet is normal.Have rosy cheeks the cough of no longer easily catching a cold.Enjoin the head of a family suitably to temper health invigorating, child begins to fill out now, and body constitution improves.

Claims

1. a Chinese medicine preparation for the treatment of infantile respiratory tract infection repeatedly is characterized in that, the ratio of weight and number of various raw materials is in the described preparation: 10～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Fructus Aurantiis, 10～15 parts of Radix Puerariaes, 10～15 parts of Rhizoma Atractylodis, 10～15 parts of Herba Schizonepetaes, 10～15 parts of Periostracum Cicadaes, 10～15 parts in Poria, 10～15 parts of the Radixs Astragali, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts of Radix Ophiopogonis, 10～15 parts of Radix Saposhnikoviaes, 10～15 parts of Radix Scutellariaes, 10～15 parts of Radix Et Rhizoma Nardostachyos, 10～15 parts of Rhizoma Kaempferiaes, 10～15 parts of Herba Asaris, 10～15 parts of Fructus Corni.

2. the Chinese medicine preparation of described treatment infantile respiratory tract infection repeatedly according to claim 1, it is characterized in that, the ratio of weight and number of various raw materials is in the described preparation: 10～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Fructus Aurantiis, 10～15 parts of Radix Puerariaes, 10～12 parts of Rhizoma Atractylodis, 10～12 parts of Herba Schizonepetaes, 10～15 parts of Periostracum Cicadaes, 10～15 parts in Poria, 10～15 parts of the Radixs Astragali, 10～15 parts of the Radixs Angelicae Dahuricae, 10～12 parts of Radix Ophiopogonis, 10～15 parts of Radix Saposhnikoviaes, 10～15 parts of Radix Scutellariaes, 10～15 parts of Radix Et Rhizoma Nardostachyos, 10～12 parts of Rhizoma Kaempferiaes, 10～15 parts of Herba Asaris, 10～12 parts of Fructus Corni.

3. the Chinese medicine preparation of described treatment infantile respiratory tract infection repeatedly according to claim 1, it is characterized in that, the ratio of weight and number of various raw materials is in the described preparation: 12～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Fructus Aurantiis, 12～15 parts of Radix Puerariaes, 12～15 parts of Rhizoma Atractylodis, 10～15 parts of Herba Schizonepetaes, 10～15 parts of Periostracum Cicadaes, 10～15 parts in Poria, 10～15 parts of the Radixs Astragali, 12～15 parts of the Radixs Angelicae Dahuricae, 12～15 parts of Radix Ophiopogonis, 10～15 parts of Radix Saposhnikoviaes, 10～15 parts of Radix Scutellariaes, 10～15 parts of Radix Et Rhizoma Nardostachyos, 10～15 parts of Rhizoma Kaempferiaes, 10～15 parts of Herba Asaris, 10～15 parts of Fructus Corni.

4. the Chinese medicine preparation of described treatment infantile respiratory tract infection repeatedly according to claim 1, it is characterized in that, the ratio of weight and number of various raw materials is in the described preparation: 10～12 parts of Rhizoma Et Radix Notopterygiis, 12～15 parts of Fructus Aurantiis, 10～15 parts of Radix Puerariaes, 10～15 parts of Rhizoma Atractylodis, 12～15 parts of Herba Schizonepetaes, 12～15 parts of Periostracum Cicadaes, 10～15 parts in Poria, 10～15 parts of the Radixs Astragali, 10～15 parts of the Radixs Angelicae Dahuricae, 10～12 parts of Radix Ophiopogonis, 10～15 parts of Radix Saposhnikoviaes, 10～15 parts of Radix Scutellariaes, 10～15 parts of Radix Et Rhizoma Nardostachyos, 10～12 parts of Rhizoma Kaempferiaes, 10～15 parts of Herba Asaris, 10～15 parts of Fructus Corni.

5. the Chinese medicine preparation of described treatment infantile respiratory tract infection repeatedly according to claim 1, it is characterized in that, the ratio of weight and number of various raw materials is in the described preparation: 12～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Fructus Aurantiis, 10～15 parts of Radix Puerariaes, 12～15 parts of Rhizoma Atractylodis, 12～15 parts of Herba Schizonepetaes, 10～15 parts of Periostracum Cicadaes, 10～15 parts in Poria, 10～15 parts of the Radixs Astragali, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts of Radix Ophiopogonis, 10～12 parts of Radix Saposhnikoviaes, 10～15 parts of Radix Scutellariaes, 10～12 parts of Radix Et Rhizoma Nardostachyos, 10～12 parts of Rhizoma Kaempferiaes, 10～15 parts of Herba Asaris, 10～12 parts of Fructus Corni.

One kind according to claim 1～5 in the Chinese medicine preparation of each described treatment infantile respiratory tract infection repeatedly, it is characterized in that described Chinese medicine preparation dosage form is oral solutions, its preparation method comprises:

7. according to claim 6 among the described step b, it is characterized in that each raw medicinal material of getting except Herba Asari, Rhizoma Et Radix Notopterygii and Rhizoma Atractylodis decocts with water three times, adds each time 5～10 times of water gagings, soak, decoct, filter; 1.10～1.15 concentrated solution left standstill 24 hours when discarded medicinal residues, merging filtrate, reduction vaporization were concentrated into relative density and are 60～70 ℃, got supernatant and get final product.

8. according to claim 7 in the described steps d, it is characterized in that concentrated solution is sterilized with CO60, irradiation dose 8k adds dextrin, then vacuum freezing sealing and get final product.

One kind according to claim 1～5 in the Chinese medicine preparation of each described treatment infantile respiratory tract infection repeatedly, it is characterized in that the preparation method that described Chinese medicine preparation dosage form is tablet comprises:

10. described preparation method according to claim 9 is characterized in that, among the described step b, get the surplus stock medicine and added water soaking 1-2 hour that 5-10 doubly measures, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid,, the 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, 1.38 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, concentrated 30 minutes～45 minutes of heating is concentrated into the extractum shape, stand for standby use becomes component 1; Among the described step c, the medicinal residues that water extraction is crossed are put into 10 times of amount ethanol, heating and refluxing extraction 1 time, extraction time is 1～2 hour, the 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, 1.38 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, concentrated 30 minutes～45 minutes of heating is concentrated into the extractum shape, stand for standby use becomes component 2.