CN102988649B

CN102988649B - Medicament for treating chronic bronchitis and preparation method of medicament

Info

Publication number: CN102988649B
Application number: CN201210416462.2A
Authority: CN
Inventors: 王勤
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-10-27
Filing date: 2012-10-27
Publication date: 2014-09-10
Anticipated expiration: 2032-10-27
Also published as: CN102988649A

Abstract

The invention discloses a medicament for treating chronic bronchitis and a preparation method of the medicament. The medicament is mainly prepared from pinellia tuber, dried orange peel, bighead atractylodes rhizome, pepperweed seed, semen brassicae, Chinese cinnamon, unibract fritillary bulb, honeysuckle flower, arisaema cum bile, rhizoma alismatis, aprieot seed and the like according to a certain weight proportion. The medicament has functions of regulating qi-flowing for strengthening spleen, diffusing the lungs, clearing internal heat, and expelling phlegm to arrest coughing, and is high in effect taking speed, short in treatment course, and high in curative rate when used for treating the chronic bronchitis without causing reoccurrence.

Description

A kind of medicine for the treatment of chronic bronchitis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of chronic bronchitis and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Chronic bronchitis is the chronic nonspecific inflammation of trachea, bronchial mucosa and surrounding tissue thereof.Clinically taking cough, expectoration or with asthma etc. repeatedly outbreak as cardinal symptom, continue 3 months every year, continuous more than 2 years.Early symptom is slight, and more than winter attack, spring and summer is alleviated.Increase the weight of because of inflammation late period, and symptom can exist throughout the year.Its Pathologic Characteristics is bronchus body of gland hypertrophy and mucosa secretion increasing.The state of an illness is slowly carrying out property progress, Chang Bingfa obstructive emphysema, and often there is pulmonary hypertension in severe patient, even pulmonary heart disease.At present Western medicine cannot effectively be treated chronic bronchitis, and long-term taking Western medicine has more side effect, and therefore, people exist great demand to the Chinese medicine of effective treatment chronic bronchitis.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment chronic bronchitis, thereby has completed the present invention.

Object of the present invention is just to provide a kind of composition of medicine that can treat chronic bronchitis.

Another object of the present invention has just been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, Semen Lepidii (Semen Descurainiae), Semen Sinapis Albae, Cortex Cinnamomi, Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Arisaema Cum Bile, Rhizoma Alismatis, Semen Armeniacae Amarum, Radix Ilicis Pubescentis, Flos Caryophylli, the Radix Angelicae Dahuricae, Semen Raphani, Rhizoma Atractylodis, Lumbricus, Radix Platycodonis, Radix Bupleuri, Herba Ephedrae, Pericarpium Trichosanthis, Poria, Fructus Perillae, Semen Persicae, Cortex Magnoliae Officinalis to combine, make each efficacy of drugs produce synergism these drug regimens, thus recurrence that can fast treating chronic bronchitis.Wherein select the Rhizoma Pinelliae to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, stomach warp, there is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass, controls damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness, outer subduing inflammation.Selecting Pericarpium Citri Reticulatae is that temperature, returns lung, spleen channel, has regulating qi-flowing for strengthening spleen because of its nature and flavor hardship, pungent, and the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Selecting the Rhizoma Atractylodis Macrocephalae is because its property bitter but sweet flavor, and temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea uneasiness.Select Semen Lepidii (Semen Descurainiae) to be because its nature and flavor are pungent, hardship, in Great Cold, returns lung, urinary bladder channel, has eliminating pathogen from the lung for relieving asthma, and the function of inducing diuresis to remove edema is controlled sputum and stopped up lung, cough with asthma abundant expectoration, and fullness and distention in the chest and hypochondrium, ascites pleural fluid is swollen, dysuria and pulmonary heart disease edema.Select Semen Sinapis Albae to be because its nature and flavor are pungent, temperature, enters lung, stomach warp, has promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, and the function of removing obstruction in the collateral to relieve pain, controls phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, regurgitation vomiting, aphasia due to apoplexy, limbs arthralgia pain numbness, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.Selecting Cortex Cinnamomi is that heat, enters kidney, spleen, urinary bladder channel, has complement sun, warming the spleen and stomach, removing accumulated cold because of its property acrid-sweet flavor, the function of promoting blood circulation, controls decline of the fire from the gate of life, cold extremities faint pulse, and YANG-depletion collapse, stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Select Bulbus Fritillariae Cirrhosae to be because its property bitter but sweet flavor is cool, enter lung meridian, have lung moistening eliminating stagnation, the function that antitussive reduces phlegm, controls cough due to consumptive disease, the spitting of blood of spitting, ambition pent-up, consumptive lung disease, lung abscess, goiter, scrofula, sore throat, acute mastitis.Select Flos Lonicerae to be because its nature and flavor are sweet, cold, enter lung, stomach warp, there is heat clearing away, the function of removing toxic substances, controls epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Select Arisaema Cum Bile to be because its nature and flavor hardship is cool in nature, enter the heart, liver, lung three warps, have clearing away fire and eliminating phlegm, the relieving convulsion Epilepsy of Dinging, phlegm-fire is breathed heavily and is coughed, phlegm-accumulating vertigo.Select Rhizoma Alismatis to be because its nature and flavor are sweet, cold, enter urinary bladder channel, there is diuretic, eliminating dampness by diuresis, the function expelling the heat-evil, controls dysuria, and edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Selecting Semen Armeniacae Amarum is because of its nature and flavor hardship, and temperature is poisonous, enters lung, large intestine channel, has expelling phlegm for arresting cough, relievings asthma, and the function of intestine moistening, controls exogenous cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation.Select Radix Ilicis Pubescentis to be because its property mildly bitter flavor is sweet, property is flat, nontoxic, have heat-clearing and toxic substances removing, the function of blood circulation and channel invigorating, controls anemopyretic cold, dyspnea and cough due to lung-heat, laryngeal edema, tonsillitis, dysentery, coronary heart disease, the hemiplegia due to cerebrovascular accident, thromboangiitis obliterans, erysipelas, scalds, central serous chorioretinopathy, uveitis, and skin acute suppurative inflammation.Select Flos Caryophylli to be because its nature and flavor are pungent, temperature, enters stomach, spleen, kidney channel, has warming middle-JIAO, warming the kidney, and the function of sending down the abnormal ascending QI, controls singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, tinea disease.Select the Radix Angelicae Dahuricae to be because its nature and flavor are pungent, temperature, enters lung, spleen, stomach warp, dispel the wind, and dampness, detumescence, the function of pain relieving, controls headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Select Semen Raphani to be because its property acrid-sweet flavor is flat, enter lung, stomach warp, have therapeutic method to keep the adverse QI flowing downwards Dingchuan, the function eliminating indigestion and phlegm, controls cough phlegm dyspnea, stagnation of QI due to dyspepsia, and abdominal distention uncomfortable in chest, heavy after dysentery.Select Rhizoma Atractylodis to be because its nature and flavor are arduous, temperature, enters spleen, stomach warp, has spleen invigorating, dampness, and resolving depression, wards off dirty function, control the wet tired spleen of containing, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens flu, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.Select Lumbricus to be because its nature and flavor are salty, cold, enter liver, spleen, lung meridian, there is heat clearing away, suppressing the hyperactive liver, Zhichuan, the function of dredging collateral, control height fanatical hot-tempered, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pants, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection.Select Radix Platycodonis to be because its nature and flavor toil is flat, enter lung, stomach warp, have out lung qi dispersing gas, the function of the evacuation of pus of eliminating the phlegm, controls exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache.Select Radix Bupleuri to be because its nature and flavor hardship is cool, enter liver, gallbladder meridian, have reconciling superficies and interior, soothing the liver, the function of yang invigorating, controls alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste deafness, headache and dizziness, malaria, diarrhea proctoptosis, menoxenia, uterine prolapse.Select Herba Ephedrae to be because its nature and flavor are arduous, temperature, enters lung, urinary bladder channel, has diaphoresis, relievings asthma, the function of diuretic, the cold table that cures the wound is real, and fever with chills is lossless, headache is had a stuffy nose, arthralgia, cough and asthma, edema due to wind pathogen edema; dysuria, ailment said due to cold or exposure insensitive impediment, munbness, rubella pruritus.Select the fruit-rind of Chinese trichosanthes to be because its nature and flavor are sweet, cold, enter lung, stomach warp, there is moistening the lung and resolving phlegm, the function of promoting the circulation of QI the chest stuffiness relieving, controls phlegm-heat cough, pharyngalgia, chest pain, spits blood, and epistaxis, quenches one's thirst, constipation, carbuncle pyogenic infections from tumour or sore.Select Poria to be because its property slightly sweet flavor is flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, controls dysuria edema distending pain, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Select Fructus Perillae to be because its nature and flavor are pungent, temperature, enters lung, large intestine channel, has the therapeutic method to keep the adverse QI flowing downwards, expectorant, and lung moistening, the function of wide intestinal, controls cough with dyspnea, phlegm dyspnea, the stagnation of QI, constipation.Select Semen Persicae to be because its property bitter but sweet flavor is flat, enter the heart, liver, large intestine channel, have blood stasis removing and clots absorbing, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Selecting Cortex Magnoliae Officinalis is that temperature, enters spleen, stomach, large intestine channel, has warming middle-JIAO because of its nature and flavor toil, the therapeutic method to keep the adverse QI flowing downwards, and dampness, the function of expectorant, controls breast abdomen feeling of fullness distending pain, regurgitation, vomiting, dyspepsia does not disappear, and phlegm retention is breathed with cough, cold-damp dysentery.

Detailed description of the invention

The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Rhizoma Pinelliae 8-20 gram of Pericarpium Citri Reticulatae 15-25 gram of Rhizoma Atractylodis Macrocephalae 10-20 gram

Semen Lepidii (Semen Descurainiae) 8-20 gram of Semen Sinapis Albae 10-20 gram of Cortex Cinnamomi 15-25 gram

Bulbus Fritillariae Cirrhosae 10-18 gram of Flos Lonicerae 15-25 gram of Arisaema Cum Bile 15-25 gram

Rhizoma Alismatis 10-18 gram of Semen Armeniacae Amarum 5-15 gram of Radix Ilicis Pubescentis 12-20 gram

Flos Caryophylli 6-10 gram of Radix Angelicae Dahuricae 16-25 gram of Semen Raphani 20-30 gram

Rhizoma Atractylodis 6-15 gram of Pheretima 13-25 gram of Radix Platycodonis 20-28 gram

Radix Bupleuri 8-15 gram of Herba Ephedrae 4-10 gram of Pericarpium Trichosanthis 6-14 gram

Poria 10-20 gram of Fructus Perillae 6-14 gram of Semen Persicae 8-18 gram

Cortex Magnoliae Officinalis 10-18 gram

Wherein, be preferably

15 grams of 20 grams of Rhizoma Atractylodis Macrocephalaes of 10 grams of Pericarpium Citri Reticulataes of the Rhizoma Pinelliae

18 grams of 15 grams of Cortex Cinnamomis of 10 grams of Semen Sinapis Albaes of Semen Lepidii (Semen Descurainiae)

18 grams of 20 grams of Arisaema Cum Bile of 12 grams of Flos Loniceraes of Bulbus Fritillariae Cirrhosae

16 grams of 8 grams of Radix Ilicis Pubescentiss of 12 grams of Semen Armeniacae Amarums of Rhizoma Alismatis

25 grams of 18 grams of Semen Raphanis of 8 grams of Radixs Angelicae Dahuricae of Flos Caryophylli

22 grams of 20 grams of Radix Platycodoniss of 10 grams of Pheretimas of Rhizoma Atractylodis

8 grams of 5 grams of Pericarpium Trichosanthiss of 10 grams of Herba Ephedraes of Radix Bupleuri

10 grams, 8 grams of Semen Persicaes of 15 grams of Fructus Perillaes of Poria

12 grams of Cortex Magnoliae Officinalis

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, the Rhizoma Pinelliae: choose decontamination, sieve dedust bits;

2, Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, softens, and shredding, dries or cold drying, sieve dedust bits;

3, the Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dries;

4, Semen Lepidii (Semen Descurainiae): get crude drug, remove impurity;

5, Semen Sinapis Albae: the former medicine most impurity of winnowing with a dustpan, fry to buff, micro-have fragrance and get final product;

6, Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the used time smashes, or scrape off rough bark, infiltrates a moment by warm water, and section, dries;

7, Bulbus Fritillariae Cirrhosae: choose decontamination, water slightly steeps, pulls out, and moistening, peels off the heart, dries;

8, Flos Lonicerae: sieve removes silt, chooses clean impurity;

9, Arisaema Cum Bile: get crude drug, choose decontamination;

10, Rhizoma Alismatis: choose decontamination, big or small stepping, is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section, dries;

11, Semen Armeniacae Amarum: choose clean impurity, put in boiling water and slightly boil, the Pi Wei that waits purses up and pulls out, soaks in cold water, sloughs seed coat, dries, winnows with a dustpan clean;

12, Radix Ilicis Pubescentis: remove impurity, clean, water runs through, and cutting is dried, sieve dedust bits;

13, Flos Caryophylli: choose decontamination, bennet, sieve dedust bits, the used time smashs to pieces;

14, the Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;

15, Semen Raphani: the decontamination of winnowing with a dustpan, rinse earth, pull out, to dry, the used time smashs to pieces;

16, Rhizoma Atractylodis: choose decontamination, with blister to seven, most probably saturating, pull out, run through rear section, dry;

17, Lumbricus: choose decontamination, water rinses, and pulls out in time, dries cutting;

18, Radix Platycodonis: choose clean impurity, except removing LU, clean and pull out, run through rear section, dry;

19, Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through rear timely section, dry immediately;

20, Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, cutting after micro-profit, dry;

21, the fruit-rind of Chinese trichosanthes: choose and freeze impurity, wash, pull out, slightly vexed, shredding, dries;

22, Poria: be soaked in water, clean pull out, vexed after, cut into slices, dry;

23, Fructus Perillae: the dedust of winnowing with a dustpan bits, clean, dry;

24, Semen Persicae: remove duricrust impurity, put in boiling water pot and boil to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;

25, Cortex Magnoliae Officinalis: be soaked in water and pull out, scrape off rough bark after running through, clean, shredding, dries.

Two, preparation

The Rhizoma Pinelliae of described weight, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, Semen Lepidii (Semen Descurainiae), Semen Sinapis Albae, Cortex Cinnamomi, Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Arisaema Cum Bile, Rhizoma Alismatis, Semen Armeniacae Amarum, Radix Ilicis Pubescentis, Flos Caryophylli, the Radix Angelicae Dahuricae, Semen Raphani, Rhizoma Atractylodis, Lumbricus, Radix Platycodonis, Radix Bupleuri, Herba Ephedrae, Pericarpium Trichosanthis, Poria, Fructus Perillae, Semen Persicae, Cortex Magnoliae Officinalis medicine are added to 6 times of water gagings, intense fire decocts boiling 25 minutes, add again the water of 3 times of amounts, use again slow fire boiling, while decocting to 600 milliliters, filter and obtain and take medicinal liquid, medicinal liquid is equally divided into 3 doses.

Medicine of the present invention has regulating qi-flowing for strengthening spleen, lung qi dispersing heat clearing away, and the function of eliminating phlegm and relieving cough, is used for the treatment of chronic bronchitis instant effect, and short treating period, does not recur, and cure rate is high.

Further set forth below the beneficial effect of medicine of the present invention by test example, these tests comprise animal toxicity test and the clinical observation test of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 20 of rabbit, male and female dual-purpose, body weight 2.3-2.5kg, divides two groups, and 10 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 30ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, once a day, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit activities, diet are normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's 300 examples for medical treatment.

2, diagnostic criteria

Chronic bronchitis: main medical history and the symptom of relying on of diagnosis.Getting rid of after other hearts, pulmonary disease (as pulmonary tuberculosis, pneumoconiosis, bronchial asthma, bronchiectasis, pulmonary carcinoma, heart disease, cardiac insufficiency etc.), all clinically have a cough chronic or repeatedly, cough up phlegm or accompany and pant, annual morbidity at least continues 3 months, and continuous 2 years or above person, diagnosis can be set up.

3, Therapeutic Method

Select above-mentioned medicament, each serving with 1 dose, every day, early, middle and late respectively taking 1 time, 15 days was a course for the treatment of, took continuously 3 courses for the treatment of.Period in a medicine smoking cessation limit wine, is careful in one's diet, and food can not be too salty, avoids food fried, easy aerogenesis, should eat high protein, high heat, homovitamin, low fat, light diet, as lean meat, egg, milk, fish, vegetable and fruit etc. more.In addition, should repeatedly drink water on a small quantity, every day, amount of drinking water was no less than 1500 milliliters, to dilute sputum, was beneficial to discharge.

4, efficacy assessment standard

Effective: clinical symptom disappearance after treatment, it is normal that bronchitis recovers, and observes half a year without recidivist;

Take a turn for the better: clinical symptoms is obviously improved, and bronchitis progressively recovers;

Invalid: clinical partial symptoms disappears or without change, do not reach improvement standard person.

5, therapeutic outcome

In above-mentioned treatment, by Drug therapy chronic bronchitis patient 300 examples of the present invention, effective 285 examples of result, obvious effective rate is 95%, 12 examples that take a turn for the better, and improvement rate is 4%, invalid 3 examples, total effective rate is 99%.

Claims

1. a medicine for the treatment of chronic bronchitis, is characterized in that: it is to be made up of the crude drug within the scope of following weight:

Rhizoma Atractylodis 6-15 gram of Lumbricus 13-25 gram of Radix Platycodonis 20-28 gram

Radix Bupleuri 8-15 gram of Herba Ephedrae 4-10 gram of fruit-rind of Chinese trichosanthes 6-14 gram

Poria 10-20 gram of Fructus Perillae 6-14 gram of Semen Persicae 8-18 gram

Cortex Magnoliae Officinalis 10-18 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

22 grams of 20 grams of Radix Platycodoniss of 10 grams of Lumbricuss of Rhizoma Atractylodis

8 grams of 5 grams of fruit-rinds of Chinese trichosanthes of 10 grams of Herba Ephedraes of Radix Bupleuri

10 grams, 8 grams of Semen Persicaes of 15 grams of Fructus Perillaes of Poria

12 grams of Cortex Magnoliae Officinalis.

3. according to the preparation method of medicine described in claim 1 or 2, it is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Rhizoma Pinelliae: choose decontamination, sieve dedust bits;

(2) Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, softens, and shredding, dries or cold drying, sieve dedust bits;

(3) Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dries;

(4) Semen Lepidii (Semen Descurainiae): get crude drug, remove impurity;

(5) Semen Sinapis Albae: the former medicine most impurity of winnowing with a dustpan, fry to buff, micro-have fragrance and get final product;

(6) Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the used time smashes, or scrape off rough bark, infiltrates a moment by warm water, and section, dries;

(7) Bulbus Fritillariae Cirrhosae: choose decontamination, water slightly steeps, pulls out, and moistening, peels off the heart, dries;

(8) Flos Lonicerae: sieve removes silt, chooses clean impurity;

(9) Arisaema Cum Bile: get crude drug, choose decontamination;

(10) Rhizoma Alismatis: choose decontamination, big or small stepping, is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section, dries;

(11) Semen Armeniacae Amarum: choose clean impurity, put in boiling water and slightly boil, the Pi Wei that waits purses up and pulls out, soaks in cold water, sloughs seed coat, dries, winnows with a dustpan clean;

(12) Radix Ilicis Pubescentis: remove impurity, clean, water runs through, and cutting is dried, sieve dedust bits;

(13) Flos Caryophylli: choose decontamination, bennet, sieve dedust bits, the used time smashs to pieces;

(14) Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;

(15) Semen Raphani: the decontamination of winnowing with a dustpan, rinse earth, pull out, to dry, the used time smashs to pieces;

(16) Rhizoma Atractylodis: choose decontamination, with blister to seven, most probably saturating, pull out, run through rear section, dry;

(17) Lumbricus: choose decontamination, water rinses, and pulls out in time, dries cutting;

(18) Radix Platycodonis: choose clean impurity, except removing LU, clean and pull out, run through rear section, dry;

(19) Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through rear timely section, dry immediately;

(20) Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, cutting after micro-profit, dry;

(21) fruit-rind of Chinese trichosanthes: choose clean impurity, wash, pull out, slightly vexed, shredding, dries;

(22) Poria: be soaked in water, clean pull out, vexed after, cut into slices, dry;

(23) Fructus Perillae: the dedust of winnowing with a dustpan bits, clean, dry;

(24) Semen Persicae: remove duricrust impurity, put in boiling water pot and boil to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;

(25) Cortex Magnoliae Officinalis: be soaked in water and pull out, scrape off rough bark after running through, clean, shredding, dries;

(2) preparation

The Rhizoma Pinelliae of described weight, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, Semen Lepidii (Semen Descurainiae), Semen Sinapis Albae, Cortex Cinnamomi, Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Arisaema Cum Bile, Rhizoma Alismatis, Semen Armeniacae Amarum, Radix Ilicis Pubescentis, Flos Caryophylli, the Radix Angelicae Dahuricae, Semen Raphani, Rhizoma Atractylodis, Lumbricus, Radix Platycodonis, Radix Bupleuri, Herba Ephedrae, the fruit-rind of Chinese trichosanthes, Poria, Fructus Perillae, Semen Persicae, Cortex Magnoliae Officinalis medicine are added to 6 times of water gagings, intense fire decocts boiling 25 minutes, add again the water of 3 times of amounts, use again slow fire boiling, while decocting to 600 milliliters, filter and obtain and take medicinal liquid, medicinal liquid is equally divided into 3 doses.