CN102100856A - Nano traditional Chinese medicine for treating bronchial asthma and preparation technology - Google Patents
Nano traditional Chinese medicine for treating bronchial asthma and preparation technology Download PDFInfo
- Publication number
- CN102100856A CN102100856A CN2009102631962A CN200910263196A CN102100856A CN 102100856 A CN102100856 A CN 102100856A CN 2009102631962 A CN2009102631962 A CN 2009102631962A CN 200910263196 A CN200910263196 A CN 200910263196A CN 102100856 A CN102100856 A CN 102100856A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- radix
- nanometer
- bronchial asthma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a nano traditional Chinese medicine for treating bronchial asthma and a preparation technology thereof. The medicine is prepared from the following raw materials containing effective ingredients in parts by weight: 8-16 parts of whiteflower hogfennel root, 10-20 parts of white peony root, 8-16 parts of cassia twig and 20-40 parts of milkvetch root. The production process thereof comprises the steps of ultrasonic wave smashing, extraction and dispersion, microwave extraction, supersonic speed spray drying smashing, nano grinding, mixing and capsule filling. The medicine in the invention lays stress on treating lung, spleen, kidney and liver with the same therapy as well as tonification and purgation in combination. The nano medicine lays stress on synergic and multi-target effects, has better treatment effect on patients suffering from bronchial asthma, and no toxic or side effect is produced. The medicine can be taken in four time periods respectively according to meridional flow and human blood flow laws. The medicine can be prepared into films to be pasted on local skin of human body and can be used for acupoint administration by transdermal absorption, thus the bronchial asthmais is treated.
Description
Technical field
The present invention relates to a kind of nanometer Chinese medicine for the treatment of bronchial asthma, the invention still further relates to this preparation technology of medicine.
Background technology
Bronchial asthma is a kind of chronic inflammation airway disorders that is participated in by multiple inflammatory cell, medium and cytokine, can cause the airway smooth muscle dysfunction, shrinking spasm with bronchial smooth muscle is feature, clinically with ictal rapid breathing difficulty, opening mouth and lifting shoulder due to dyspnea, flaring of nares, wheezing sound in the throat has sound, very then must not pant and equalling the symptom that is for sleeping in, it is the respiratory system common disease, its sickness rate, mortality rate rise year by year, the whole world has 1,500,000,000 people to suffer from asthma approximately, in state-owned 1,000 ten thousand～2,000 ten thousand patients, with between twenty and fifty and the child is in the majority.Become the main chronic disease of serious harm people ' s health.Its prevention has become the Chinese and western medicine current focus of attention of author clinically with treatment.
Bronchial asthma is by the various kinds of cell chronic airway inflammation that participates in of mastocyte, eosinophilic granulocyte and T lymphocyte particularly; This kind inflammation can cause repeatedly symptoms such as the panting of outbreak, tachypnea, uncomfortable in chest or cough in the susceptible person.Asthma is a kind of by multiple inflammatory cell, and therefore the chronic inflammation airway disorders that medium and cytokine participate in diminishes inflammation, and the control asthma attack is the key of treatment asthma.Doctor trained in Western medicine pathology confirms that bronchial mucosa has eosinophilic granulocyte and lymphocytic infiltration in early days.The bronchia smooth muscle has slight plumpness.Along with PD, and can have bronchus, bronchia mucous secretion to increase, the damage of basement membrane thickened degeneration and ciliated epithelial cell, variation such as come off.Late period can concurrent obstructive emphysema.Asthma continues the visible sticky expectorant bolt of outbreak and blocks bronchia and bronchioles, causes local pulmonary atelectasis, and emphysema finally can cause chronic pulmonary heart disease.Violent disease appearing at regular intervals can concurrent pneumothorax.
Differential diagnosis in tcm: primary disease belongs to " heavy breathing ", " breathing heavily ", " phlegm retention " sick category of the traditional Chinese medical science.It is sound for ring breath in the larynx to roar, and breathes heavily to be tachypnea and dyspnea, and the two has concurrently and is called asthma.The main diseases of primary disease can not fallen ill at ordinary times because of being volt in the phlegm retention, meets certain factor and causes phlegm retention to be fought with in air flue to fall ill.The paathogenic factor more complicated, all affection of exogenous wind-cold summer-heat fails in time to show to loose, and heresy hinders in lung, and gas is cloth Tianjin not, and poly-liquid becomes expectorant.The salty delicious food of diet acid, raw and cold raw meat is greasy and cause dysfunction of the spleen in transportation, interior wine phlegm-damp, on do in lung, stop up the resistance lung qi.Plain report weak, or body void after being ill, as childhood measles, pertussis and repeated cold, having coughed for a long time, excess of YIN due to YANG-insufficiency, failure of qi transforming fluid is given birth to or the deficiency of YIN excess of YANG in the phlegm retention, it is poly-that heat is steamed liquid, the expectorant hot glue is solid.This shows that the main pathological factor that causes primary disease is an expectorant, so-called " asthma is specially main in expectorant ", diseases caused by exogenous pathogenic factor, diet, imbalance after being ill, feelings will internal injury, fatigue etc. all are risk factors.The traditional Chinese medical science thinks, the syndrome of dyspnea is meant because being invaded by exogenous pathogen accumulates in expectorant is turbid, disorder of emotion and cause abnormal rising of lung-QI, lose a surname Yu and fall, or the prolonged illness deficiency of vital energy, lose in taking the photograph and receive, with dyspnea, very then opening mouth and lifting shoulder due to dyspnea, flaring of nares can not be put down for sleeping in the grade and being a kind of common disease of main clinical manifestation.The common lung of primary disease, spleen, kidney, liver tool void, about the cause of disease of the syndrome of dyspnea, say as " danxi's experiential therapy is breathed heavily ": " institute of six climate exopathogens seven emotions hinders, the action of being satiated with food, and the visceral-qi discord, the breath of breathing, must not declare freely is dyspnea with rapid respiration.The all empty weak people of spleen kidney are also arranged, all can breathing heavily." Ming Dynasty's Zhang Jingyue reduces deficiency and excess two cards to the syndrome of dyspnea, " Jing Yue's complete work dyspnea with rapid and short breath " said: " the excess-dyspnea person has heresy, and excess of pathogen is also; Dyspnea due to deficiency person naivete, first deficiency of vital energy also." comprised the syndrome of dyspnea that causes " breath of breathing must not be declared smooth " by the strongly fragrant lung of cold-phlegm in the excess-dyspnea.About the formation of cold-phlegm, mainly be because the diseases caused by exogenous pathogenic factor cold-evil, the visitor is in internal organs or innate deficiency of YANG in the body, can not be warm and give birth to endogenous cold, or both have both at the same time, and influences the gasification of internal organs to water liquid, make that water liquid transfers, compress generation obstacle, so that water liquid stops and the generation phlegm retention poly-.Cold-evil and phlegm retention are handed over resistance, and lung qi is stopped up stagnant, thus see side of body rib distension, abnormal rising of lung-QI, so see dyspnea with rapid and short breath, stagnation of phlegm air flue, gas touch its expectorant, so see gurgling with sputum such as water bird sound.Kidney governing inspiration is led by lung though breathe, and the gas of suction must descend and in kidney, is taken the photograph for it by kidney qi and receives.Confirmed that insufficiency of kidney-YANG is the most basic pathomechanism of primary disease, the control asthma attack is worked as with the kidney invigorating warming YANG improving inspiration by invigorating kidney-QI for wanting." Lei Zheng Zhi Cai? asthma " cloud: " the lung being the dominator of QI; the kidney being the root of QI. lung the master give vent to anger; kidney governing inspiration; negative and positive intersect; breathing be and. if come in and go out abnormal ascending-descending of QI. this here breathe heavily work " illustrated the outbreak of asthma and the substantial connection of lung kidney. Chinese medicine emphasize asthma with " long-standing " and relevant. phlegm retention volt lung is long-standing of asthma, in view of the above should a traditional Chinese medical science " sick phlegm retention person. when with warm medicine and it " serve as to treat rule.The generation of expectorant this in asthenia of both the spleen and kidney, the void of spleen kidney, it comes also gradually, it goes also slow, and this is that asthma is controlled repeatly repeatly and sent out the reason place that prolonged difficulty heals, the product of advocating to use temperature male wind-supplying kidney strengthen patient's body constitution to consolidate, and " healthy energy is deposited interior " could really break off the perennial root of asthma.In addition, pathological changes such as stagnation of liver-QI QI rising in reverse order, liverzang-fire attacking lung, the ring of wind rocking clock, stagnated phlegm impairing the lung also can appear in liver, lung two dirty functional disorders, thereby cause the generation of asthma.Asthma should be deficiency in origin and excess in superficiality at the pathogenesis of acute stage, and mark is real to be wind, expectorant, gas, the stasis of blood, and deficiency in origin is the lung qi deficiency of YIN-blood.Asthma gradually reaches the liver spleen just at lung, and with the passing of time heart kidney is got involved.Disease develops into the serious stage, not only lung spleen kidney is all empty, in lonely sun desires to take off, have influence on the heart, all empty as lung spleen kidney, then the motive, heart-yang can not be agitated the blood vessels operation more, the blood clots absorbing stagnates and meeting color, color of the lip, fingernail are livid purple, dyspnea and sweating very then occurs and cause and take off, the dangerous symptom of exhaustion of YIN YANG-depletion, this is the clinical findings status asthmaticus.
The effect of main Chinese medicine among the present invention:
A little less than the gas yang deficiency the important endogenous cause of ill that asthma is shown effect repeatedly, Radix Astragali benefiting QI for strengthening the superficies among the we.Radix Angelicae Sinensis sweet in the mouth suffering, warm in nature, can enrich blood with activating QI.Ramulus Cinnamomi, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens, Radix Angelicae Sinensis, Herba Ephedrae (processed), Gypsum Fibrosum, Fructus Schisandrae Chinensis Chinese medicine etc. can reduce asthmatic patient air flue eosinophilic granulocyte quantity, reduces ECP's level and reduces the reactivity of air flue, thereby effectively prevent and reduce the outbreak of asthma.Have the effect that strengthens patient's peripheral blood lymphocyte acceptor quantity, can correct too high receptor affinity again simultaneously, can avoid, receptor stimulating agent and the bronchorelaxing activity that causes because of life-time service.Radix Angelicae Sinensis composition n-butene husband's lactone and ligustilide have relaxation effect to tracheal smooth muscle, the bronchial asthma that energy antagonism group limb-acetylcholine causes.
Radix Morindae Officinalis is because of the sweet in the mouth suffering, the kidney warming sun and fall dry, but exorcising training Yuanyang, ailment said due to cold or exposure is gone, then defend not strong, Wei Buqiang can with flourish and, Rong Wei peace.Cooperate Semen Coicis spleen invigorating dehumidifying and in, to change the taste kidney raw, cooperates the Ramulus Cinnamomi sweet and pungent flavors inducing perspiration and pertaining to yang; Radix Morindae Officinalis can reduce patient's acidophil absolute counting level, eliminates airway inflammation, thereby plays warming and recuperating the kidney-YANG, and the helping inspiration to relieve asthma effect improves patient's symptom and pulmonary function.The Radix Peucedani effective ingredient is mainly Coumarins, has antipyretic-antalgic, effects such as the wind heat clearing away of loosing, lowering the adverse-rising QI to resolve phlegm, clinical be used for the treatment of cough due to pathogenic wind-heat, expectorant dyspnea of heat type full, cough up phlegm yellow thick etc.Fructus Perillae sending down the abnormal ascending QI Dingchuan, promoting the circulation of QI reduces phlegm.The Pericarpium Citri Reticulatae activating QI to eliminate phlegm.The promoting the circulation of QI that reduces phlegm such as Fructus Perillae, Semen Armeniacae Amarum.The Poria air making-up and spleen enlivening.Gecko the kidney invigorating lung benefiting improving inspiration by invigorating kidney-QI.Radix Codonopsis spleen reinforcing nourishing the stomach, the lung moistening and production of body fluid promoting, gas in the strong fortune.Pheretima has antiasthmatic effect, and bronchus is had significant diastole effect.Fructus Schisandrae Chinensis convergence lung qi, the Flos Lonicerae heat-clearing and toxic substances removing.Cnidium lactone A pretreatment in the Rhizoma Chuanxiong can improve coronary flow and the myocardial contraction that heart ischemia is irritated the phase again, reduce that quiver in the chamber and the incidence rate of chamber speed, make lactic acid dehydrogenase (LDH), malonaldehyde (MDA) content of myocardium homogenate reduce superoxide dismutase (SOD) increased activity.Flos Magnoliae is a diaphoretic medicine commonly used, its warm in nature, acrid in the mouth, attach to the lung and stomach meridians, effect with dispersing wind and cold, clearing the nasal passage, the effect that Flos Magnoliae volatile oil (VOMbP) has significant antianaphylaxis airway inflammation, be in particular in: 1. can obviously prolong drawing of sensitized animal breathes heavily incubation period, alleviates the symptom of the early stage phase reaction of asthma.2. can suppress asthma animal phase in late period blood circulation and air flue eosinophilic granulocyte's (EOS) increase and infiltration, inflammatory cells such as antagonism EOS.
Contained theophylline can relaxing smooth muscle in the Folium Camelliae sinensis rich in selenium, so in order to treat bronchial asthma.Trace element-selenium can effectively prevent and treat asthma.Studies show that: asthma patient is after selenium supplement, and clinical symptoms all can take a turn for the better, and cough alleviates, amount of expectoration reduces, wheezing sound reduces or disappearance in the lung, pulmonary function is significantly improved, and especially SAO obviously alleviates, and selenium has important meaning to prevention and treatment asthma.The extract of Radix Tripterygii Wilfordii (triptolide) has the effect that reduces the animal model in asthma airway reactivity, and its mechanism may be relevant with the HEos that reduces " activation ".Has potential clinical value.
Fructus Psoraleae is the legumes psoraleae fruit, and is warm in nature, acrid in the mouth, the kidney invigorating yang deficiency, the effect of tool reinforcing the kidney and supporting YANG.Cure mainly the cold diarrhea of suffering from a deficiency of the kidney, frequent micturition, sexual impotence, chills and pain of the waist and kness, deficiency and coldness is breathed with cough.Modern study shows that Fructus Psoraleae has blood vessel dilating, increases myocardial contraction, and is antibiotic, the effect of estrogen sample, and Fructus Psoraleae total coumarins is to all there being incubation period of allergic asthma and histamine asthma significant prolongation effect.Fructus Psoraleae total coumarins can directly be expanded the guinea pig bronchial smooth muscle, and can be shunk by the bronchial smooth muscle that histamine causes by antagonism.Fructus Psoraleae total coumarins has Zhichuan effect preferably, and asthma is had tangible antagonism.
The Rhizoma Belamcandae clearing throat, the lung qi dispersing eliminating phlegm, Rhizoma Belamcandae extract has obvious clinical efficacy to the senile asthma patient, and to take off granule relevant with suppressing the eosinophilic granulocyte.The senile asthma patient adds when carrying out conventional therapy and uses the Rhizoma Belamcandae decoction, obviously shortens than the conventional therapy group course of disease, and clinical symptom remission is very fast, and main lung function index FEV1 and PEF obviously improve, and ECP is improved significantly be better than the conventional therapy group.Herba Ephedrae depressed lung-energy dispersing, Herba Ephedrae have lax bronchial smooth muscle of expansion and antiinflammation.Ephedroxane helps disappearing of respiratory inflammation in the Herba Ephedrae, and Herba Ephedrae water extract, ethanol extract can suppress sensitive media and discharge.The Rhizoma Belamcandae Herba Ephedrae can be improved the pulmonary function of asthmatic patient, can reduce endothelin level, blood plasma viscosity level.Radix Glycyrrhizae has raise immunity, anti-allergic effects and antiasthmatic effect.Drying dampness to eliminate phlegm such as Pericarpium Citri Reticulatae, Poria, Fructus Perillae, Semen Coicis, tonifying speen and tonifying kidney.Semen Coicis benefit diuretic is wet, tonifying YIN and invigorating middle warmer and battalion; Ramulus Cinnamomi temperature compensation kidney the yang aspect of yang.Ramulus Cinnamomi focuses on harmonizing yingfen and weifen two gas, and square Ramulus Cinnamomi acrid-sweet flavor temperature is gone into spleen, heart channel, and Xin Wen disperses, suffering is opened lung qi, promoting the flow of QI-blood by warming the meridian, activate yang and cloudy activating QI, diuresis; The logical three warmers of transferring of the Rhizoma Pinelliae, acrid in the mouth warm in nature looses, and assistant Ramulus Cinnamomi cold expelling opening lung-energy is promptly by the cold strong defensive QI weak nutrient QI that causes of ailment said due to cold or exposure (sun is floating cloudy weak), only to induce sweat.
The present invention adopts selenium-enriched nano Chinese medicine and many collaborative, many targeted therapies schemes.Dialectical opinion is controlled and is adopted sun to make main rationale greater than cloudy theoretical, positive six cloudy four therapies, pay attention to the human body integral idea, emphasize that the vital organs of the human body, the four stages in the course of an epidemic febrile disease, body fluid marrow are in harmonious proportion with mending, the cold warm medicine of a cold nature of heat and develop simultaneously, flow to the position medication of timesharing branch by the midnight-noon and ebb-flow doctrine QI and blood with, inside and outside administration.Used Chinese medicine mostly is rich in the high-activity nano organic selenium, has anti-airway allergy inflammation, airway hyperreactivity, enhancing immune function of human body, antiviral and antiphlogistic effect.Can directly or indirectly suppress the infiltration of inflammatory cells such as lymphocyte, thereby suppress airway inflammation, reduce airway hyperreactivity.
Its drug effect of nanometer Chinese medicine of the present invention and function and sun six cloudy four treatment mechanism focus on training mend eliminating evil, Wen Huaxuan looses, the respectful lung of expectorant, giving consideration to both the incidental and fundamental.The bronchial asthma patient is recovered gradually, can be used for various bronchitis, bronchial asthma.Can strengthen patient's body's immunity, treatment bronchial asthma good effect, duration of efficacy is long, and late result is stable, the cure rate height, and without any toxic and side effects.And can take four time periods respectively by midnight-noon and ebb-flow doctrine, energy and blood of human body flowing law.Nanometer Chinese medicine is made plaster be attached to the affected part, can directly absorb by skin.
Further, various rich selenium Chinese medicine nanometer particle size major parts are the granule of 50-1000 nanometer among the present invention, cells such as the penetrable lung of tunnel-effect, liver, spleen are arranged, strengthen nanometer selenium, Chinese medicine one matter and Chinese medicine active substance group attack, infected tissue is recovered gradually virus, inflammatory cell.This prescription and effective ingredient treatment bronchial asthma thereof realize that by many target spots, multipath, too many levels the theoretical basis of this prescription selenium-enriched nano Chinese medicine and effective ingredient thereof will be opened up new approach for treatment bronchial asthma.The preparation of we's Nano medication, abstraction technique advanced person, the dosage form novelty, used effective ingredient is clear and definite, and medicine effect has obtained admitting of modern medicine, and these will promote the development of China's Chinese medicine industry.
Summary of the invention:
Purpose of the present invention is exactly in order to solve the above-mentioned problems in the prior art, and a kind of treatment bronchial asthma nanometer Chinese medicine and technology of preparing are provided.
Purpose of the present invention is achieved through the following technical solutions:
A kind of treatment bronchial asthma nanometer Chinese medicine and technology of preparing, wherein: this nanometer Chinese medicine raw materials of effective components and weight proportion---
Radix Peucedani 8-16 part, Radix Paeoniae Alba 10-20 part, Ramulus Cinnamomi 8-16 part, Radix Astragali 20-40 part, Radix Codonopsis 20-40 part, Rhizoma Chuanxiong 8-16 part, Pheretima 15-30 part, Radix Platycodonis 8-16 part, the 8-16 part of quenching the thirst, Rhizoma Pinelliae 6-12 part, Radix Scutellariae 10-20 part, Gypsum Fibrosum 20-30 part, Radix Glycyrrhizae 5-10 part, Poria 8-16 part, Radix Angelicae Dahuricae 8-16 part, Radix Angelicae Sinensis 13-30 part, Semen Armeniacae Amarum 8-16 part, Cortex Magnoliae Officinalis 8-16 part, Pericarpium Citri Reticulatae 8-16 part, Fructus Perillae 10-20 part, Gecko 1-2 part, Bombyx Batryticatus 10-20 part, Fructus Forsythiae 10-20 part, Flos Magnoliae 8-16 part, Rhizoma Belamcandae 10-20 part, Fructus Schisandrae Chinensis 10-20 part, Fructus Psoraleae 10-20 part, tea rich in selenium 8-16 part, Radix Tripterygii Wilfordii 10-20 part, Semen Coicis 20-40 part, Radix Morindae Officinalis 10-20 part, Herba Ephedrae (processed) 5-10 part, Flos Lonicerae 15-30 part, Herba Houttuyniae 20-40 part.
Above-mentioned a kind of treatment bronchial asthma nanometer Chinese medicine and technology of preparing, wherein: the weight proportion of described each raw material is---
Radix Peucedani 8-15 part, Radix Paeoniae Alba 12-18 part, Ramulus Cinnamomi 8-12 part, Radix Astragali 25-35 part, Radix Codonopsis 25-35 part, Rhizoma Chuanxiong 8-12 part, Pheretima 15-25 part, Radix Platycodonis 8-12 part, the 8-12 part of quenching the thirst, Rhizoma Pinelliae 6-10 part, Radix Scutellariae 12-18 part, Gypsum Fibrosum 20-25 part, Radix Glycyrrhizae 5-8 part, Poria 8-12 part, Radix Angelicae Dahuricae 8-12 part, Radix Angelicae Sinensis 18-25 part, Semen Armeniacae Amarum 8-12 part, Cortex Magnoliae Officinalis 8-12 part, Pericarpium Citri Reticulatae 8-12 part, Fructus Perillae 10-18 part, Gecko 1-1.5 part, Bombyx Batryticatus 10-15 part, Fructus Forsythiae 12-18 part, Flos Magnoliae 8-12 part, Rhizoma Belamcandae 12-18 part, Fructus Schisandrae Chinensis 12-18 part, Fructus Psoraleae 12-18 part, tea rich in selenium 8-12 part, Radix Tripterygii Wilfordii 12-18 part, Semen Coicis 20-30 part, Radix Morindae Officinalis 12-18 part, Herba Ephedrae (processed) 5-8 part, Flos Lonicerae 15-25 part, Herba Houttuyniae 20-30 part.
Further, above-mentioned a kind of treatment bronchial asthma nanometer Chinese medicine and technology of preparing, wherein: the weight proportion of described each raw material is---
10 parts of Radix Peucedanis, 15 parts of the Radix Paeoniae Albas, 10 parts of Ramulus Cinnamomi, 30 parts of the Radixs Astragali, 30 parts of Radix Codonopsis, 10 parts of Rhizoma Chuanxiongs, 18 parts of Pheretimas, 10 parts of Radix Platycodoniss, quench the thirst 10 parts, 8 parts of the Rhizoma Pinelliaes, 15 parts of Radix Scutellariaes, 22 parts in Gypsum Fibrosum, 6 parts in Radix Glycyrrhizae, 10 parts of Poria, 10 parts of the Radixs Angelicae Dahuricae, 20 parts of Radix Angelicae Sinensis, 10 parts in Semen Armeniacae Amarum, 10 parts of Cortex Magnoliae Officinalis, 10 parts of Pericarpium Citri Reticulataes, 15 parts of Fructus Perillaes, 1 part of Gecko, 12 parts of Bombyx Batryticatus, 15 parts of Fructus Forsythiaes, 10 parts of Flos Magnoliaes, 15 parts of Rhizoma Belamcandae, 15 parts of Fructus Schisandrae Chinensis, 15 parts of Fructus Psoraleaes, 10 parts of tea rich in selenium, 15 parts of Radix Tripterygii Wilfordiis, 25 parts of Semen Coiciss, 15 parts of Radix Morindae Officinaliss, 6 parts of Herba Ephedrae (processed), 20 parts of Flos Loniceraes, 25 parts of Herba Houttuyniae.
Further, above-mentioned a kind of treatment bronchial asthma nanometer Chinese medicine and technology of preparing, wherein: adopt sun greater than yin, yang six cloudy four theoretical research and development Ben Nami Chinese medicines.Said nanometer Chinese medicine had both contained Chinese medicine extract nanometer dry powder, contained Chinese medicine water drug-decocting concentrating liquid nanometer dry powder again.Final products of the present invention can be tablet, pill, powder, suppository, granule, membrane, capsule, microcapsule, effervescent, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution, plaster.
Again further, above-mentioned a kind of treatment bronchial asthma nanometer Chinese medicine and technology of preparing, wherein: said ingredient is rich in the nanometer organic selenium, nanometer Chinese medicine of the present invention can be taken in four time periods of every day respectively by midnight-noon and ebb-flow doctrine energy and blood of human body flowing law, by different time stick at body local skin, acupuncture point administration Transdermal absorption treatment.
A kind of treatment bronchial asthma nanometer Chinese medicine and technology of preparing, it may further comprise the steps:
Step 1: pretreatment, get the common Chinese decoction pieces of respectively distinguishing the flavor of, each flavor Chinese medicine is inserted pulverizer respectively be crushed to the 80-200 order, adopt supersonic airstream to be crushed to the 1-10 micron then, get each Chinese medicine micropowder, standby.
Step 2: get 25% each Chinese medicine micropowder, extract pulverizing with high-frequency ultrasonic respectively, ultrasonic power is: 1500W-3000W, supersonic frequency: 28KHz--120KHz, to pulverize extraction time be 10-100 minute.Get each Chinese medicine extract, standby.
Step 3: get 25% each Chinese medicine micropowder, carry out various medicines with microwave extracting respectively and propose extraction, microwave power is set under the 40-80% (1000 watts of peak powers), make solvent with 38%-45% ethanol, solvent 25-35 doubly measures, pressure 0.10-0.25Mpa, constant voltage time 30-60 can obtain dissolution rate preferably second.Get each Chinese medicine extract, standby.
Step 4: get each Chinese medicine micropowder of 40% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges and filters, and filtrate concentrates, and gets water drug-decocting concentrating liquid with standby.
Step 5: adopt supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) spray drying to be crushed to the 1-5 micron grain size respectively above-mentioned each Chinese medicine extract and water drug-decocting concentrating liquid.Get each Chinese medicine extract micron order dry powder.
Step 6: get Chinese medicine micropowder and above-mentioned each Chinese medicine extract micron order dry powder of 10%, adopt the swing nanon ball-mill of independent research to grind respectively 4-16 hour, obtain particle size distribution and be the various Chinese medicine nano powders of 50-1000 nanometer, standby.
Step 7: in GMP10000 level toilet, above-mentioned various Chinese medicine nano powders are mixed by described Billy.
Step 8: in GMP10000 level toilet, make aforementioned various preparation by version Chinese Pharmacopoeia second portion standard preparation standard in 2005.
Step 9: each formulation products is pasted labeling respectively, played exterior and interior packings such as sign indicating number, vanning.
Step 10: packaged product carries out instantaneously sterilising respectively by production batch, and opens the sterilization report.
Above-mentioned a kind of treatment bronchial asthma nanometer Chinese medicine and technology of preparing, wherein: described step 2 is being carried out in the leaching process with high-frequency ultrasonic, can carry out the dispersion and the pulverizing of powder simultaneously.
Further, above-mentioned a kind of treatment bronchial asthma nanometer Chinese medicine and technology of preparing, wherein: described step 3 is carried out various medicines with microwave extracting and is carried when extraction, can collect volatile active substance in the medicine simultaneously.
Further, above-mentioned a kind of treatment bronchial asthma nanometer Chinese medicine and technology of preparing, wherein: described step 6 is carried out nano-milled with the swing nanon ball-mill of independent research, is with the powder ball grinder of bacterium of going out of packing into, grinds 4～16 hours with the nano double planetary ball mill.60～80 degrees centigrade the high temperature that produces when grinding with the swing nanon ball-mill of independent research simultaneously, can carry out high temperature sterilize to raw material.
Again further; above-mentioned a kind of treatment bronchial asthma nanometer Chinese medicine and technology of preparing; wherein: the described protection domain of this claim is not only described preparation method and technology; as required, be also included within add on its basis or use other better effects if, more economical, upgrade, more advanced preparation method and technology.
The outstanding substantive distinguishing features and the obvious improvement of technical solution of the present invention is mainly reflected in: the present invention adopts sun greater than a kind of treatment bronchial asthma nanometer Chinese medicine of cloudy theoretical development, prove the present domestic reported literature that has the utilization sun to research and develop the nanometer tcm product greater than cloudy theory of not seeing according to the novelty assessment report conclusion.Prescription is to adopt sun to make main dialectical opinion greater than yin, yang six cloudy four theories to control method, pays attention to the collaborative idea of human body integral, pays attention to selenium-enriched nano medicine Synergistic treatment scheme.Emphasize that the vital organs of the human body, the four stages in the course of an epidemic febrile disease, body fluid marrow are in harmonious proportion with mending, the cold warm medicine of a cold nature of heat and with, inside and outside administration develop simultaneously, the midnight-noon and ebb-flow doctrine QI and blood flows to the position medication of timesharing branch.This prescription is by setting upright timid heresy, monarch reasonable compatibility, and the Chinese medicine of will filling a prescription is taken four time periods respectively by midnight-noon and ebb-flow doctrine, energy and blood of human body flowing law.Nanometer Chinese medicine is made film former or plaster is attached to the affected part, can directly absorb and need not inject, strengthened single variety anti-inflammatory, antiviral ability and biological activity behind the prescription nanorize, reach the purpose of enhancing immunity, treatment bronchial asthma by skin.This prescription is taken for a long time and is had no side effect.The mode of production has then been gathered the integration that high-frequency ultrasonic extracts advanced technologies such as disperseing crushing technology, microwave extracting technology of preparing, supersonic speed dry technology, the grinding of efficient physical nanoscale.The prescription theory is to be based upon on a large amount of traditional Chinese medical science works, pharmacology of Chinese materia medica, pharmacodynamics, toxicology, biotechnology, modern pharmaceutical technology, high frequency ultrasound wave technology, microwave-assisted extraction technique, the nanotechnology scheduling theory, is many interdisciplinary technology set.This shows that the present invention has substantive technical characterstic and significant technological progress, its application prospect is boundless.
Process route of the present invention is: get the common Chinese decoction pieces of respectively distinguishing the flavor of, pretreatment is inserted pulverizer respectively with each flavor Chinese medicine and is crushed to the 80-200 order, adopts supersonic airstream to be crushed to the 1-10 micron then, gets each Chinese medicine micropowder, and is standby.Get 25% each Chinese medicine micropowder, extract pulverizing with high-frequency ultrasonic respectively, ultrasonic power is: 1500W-3000W, supersonic frequency: 28KHz-120KHz, to pulverize extraction time be 10-100 minute.Get each Chinese medicine extract, standby.Get 2% each Chinese medicine micropowder, carry out various medicines with microwave extracting respectively and propose extraction, microwave power is set under the 40--80% (1000 watts of peak powers), make solvent with 38%--45% ethanol, solvent 25-35 doubly measures, pressure 0.10-0.25Mpa, constant voltage time 30-60 can obtain dissolution rate preferably second.Get each Chinese medicine extract, standby.Get each Chinese medicine micropowder of 40% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges and filters, and filtrate concentrates, and gets water drug-decocting concentrating liquid with standby.Adopt supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) spray drying to be crushed to the 1-5 micron grain size respectively above-mentioned each Chinese medicine extract and water drug-decocting concentrating liquid.Get each Chinese medicine extract micron order dry powder.Get Chinese medicine micropowder and above-mentioned each Chinese medicine extract micron order dry powder of 10%, adopt the swing nanon ball-mill of independent research to grind respectively 4-16 hour, obtain particle size distribution and be the various Chinese medicine nano powders of 50-1000 nanometer, standby.In GMP10000 level toilet, above-mentioned various Chinese medicine nano powders are mixed by described Billy.In GMP10000 level toilet, make aforementioned various preparation by version Chinese Pharmacopoeia second portion standard preparation standard in 2005.Each formulation products is pasted labeling respectively, played exterior and interior packings such as sign indicating number, vanning.Packaged product carries out instantaneously sterilising respectively by production batch, and opens the sterilization report.
Purpose of the present invention, advantage and characteristics will make an explanation by the non-limitative illustration of following preferred embodiment.These embodiment only are the prominent examples of using technical solution of the present invention, and all technical schemes of taking to be equal to replacement or equivalent transformation and forming all drop within the scope of protection of present invention.
The specific embodiment
A kind of treatment bronchial asthma nanometer Chinese medicine and technology of preparing, its special feature is: making the raw materials of effective components composition is by weight ratio---
Radix Peucedani 8-16 part, Radix Paeoniae Alba 10-20 part, Ramulus Cinnamomi 8-16 part, Radix Astragali 20-40 part, Radix Codonopsis 20-40 part, Rhizoma Chuanxiong 8-16 part, Pheretima 15-30 part, Radix Platycodonis 8-16 part, the 8-16 part of quenching the thirst, Rhizoma Pinelliae 6-12 part, Radix Scutellariae 10-20 part, Gypsum Fibrosum 20-30 part, Radix Glycyrrhizae 5-10 part, Poria 8-16 part, Radix Angelicae Dahuricae 8-16 part, Radix Angelicae Sinensis 13-30 part, Semen Armeniacae Amarum 8-16 part, Cortex Magnoliae Officinalis 8-16 part, Pericarpium Citri Reticulatae 8-16 part, Fructus Perillae 10-20 part, Gecko 1-2 part, Bombyx Batryticatus 10-20 part, Fructus Forsythiae 10-20 part, Flos Magnoliae 8-16 part, Rhizoma Belamcandae 10-20 part, Fructus Schisandrae Chinensis 10-20 part, Fructus Psoraleae 10-20 part, tea rich in selenium 8-16 part, Radix Tripterygii Wilfordii 10-20 part, Semen Coicis 20-40 part, Radix Morindae Officinalis 10-20 part, Herba Ephedrae (processed) 5-10 part, Flos Lonicerae 15-30 part, Herba Houttuyniae 20-40 part.
With regard to the present invention's one preferred embodiment, described each raw material can adopt following weight proportion: 10 parts of Radix Peucedanis, 15 parts of the Radix Paeoniae Albas, 10 parts of Ramulus Cinnamomi, 30 parts of the Radixs Astragali, 30 parts of Radix Codonopsis, 10 parts of Rhizoma Chuanxiongs, 18 parts of Pheretimas, 10 parts of Radix Platycodoniss quench the thirst 10 parts, 8 parts of the Rhizoma Pinelliaes, 15 parts of Radix Scutellariaes, 22 parts in Gypsum Fibrosum, 6 parts in Radix Glycyrrhizae, 10 parts of Poria, 10 parts of the Radixs Angelicae Dahuricae, 20 parts of Radix Angelicae Sinensis, 10 parts in Semen Armeniacae Amarum, 10 parts of Cortex Magnoliae Officinalis, 10 parts of Pericarpium Citri Reticulataes, 15 parts of Fructus Perillaes, 1 part of Gecko, 12 parts of Bombyx Batryticatus, 15 parts of Fructus Forsythiaes, 10 parts of Flos Magnoliaes, 15 parts of Rhizoma Belamcandae, 15 parts of Fructus Schisandrae Chinensis, 15 parts of Fructus Psoraleaes, 10 parts of tea rich in selenium, 15 parts of Radix Tripterygii Wilfordiis, 25 parts of Semen Coiciss, 15 parts of Radix Morindae Officinaliss, 6 parts of Herba Ephedrae (processed), 20 parts of Flos Loniceraes, 25 parts of Herba Houttuyniae.
Again further, nanometer Chinese medicine of the present invention can be fast in the gastrointestinal disintegrate, in water, in the body solid dispersion good, absorb rapidly fully, bioavailability is good, stronger targeting and tunneling are arranged, effective ingredient pharmacological action effect is significantly higher than conventional formulation.
Production method of the present invention may further comprise the steps: get the common Chinese decoction pieces of respectively distinguishing the flavor of, pretreatment is inserted pulverizer respectively with each flavor Chinese medicine and is crushed to the 80-200 order, adopts supersonic airstream to be crushed to the 1-10 micron then, gets each Chinese medicine micropowder, and is standby.Get 25% each Chinese medicine micropowder, extract pulverizing with high-frequency ultrasonic respectively, ultrasonic power is: 1500W-3000W, supersonic frequency: 28KHz-120KHz, to pulverize extraction time be 10-100 minute.Get each Chinese medicine extract, standby.Get 25% each Chinese medicine micropowder, carry out various medicines with microwave extracting respectively and propose extraction, microwave power is set under the 40-80% (1000 watts of peak powers), make solvent with 38%--45% ethanol, solvent 25-35 doubly measures, pressure 0.10-0.25Mpa, constant voltage time 30-60 can obtain dissolution rate preferably second.Get each Chinese medicine extract, standby.Get each Chinese medicine micropowder of 40% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges and filters, and filtrate concentrates, and gets water drug-decocting concentrating liquid with standby.Adopt supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) spray drying to be crushed to the 1-5 micron grain size respectively above-mentioned each Chinese medicine extract and water drug-decocting concentrating liquid.Get each Chinese medicine extract micron order dry powder.Get Chinese medicine micropowder and above-mentioned each Chinese medicine extract micron order dry powder of 10%, adopt the swing nanon ball-mill of independent research to grind respectively 4-16 hour, obtain particle size distribution and be the various Chinese medicine nano powders of 50-1000 nanometer, standby.In GMP10000 level toilet, above-mentioned various Chinese medicine nano powders are mixed by described Billy.In GMP10000 level toilet, make aforementioned various preparation by version Chinese Pharmacopoeia second portion standard preparation standard in 2005.Each formulation products is pasted labeling respectively, played exterior and interior packings such as sign indicating number, vanning.Packaged product carries out instantaneously sterilising respectively by production batch, and opens the sterilization report.
" embodiment one "
Prepare the nanometer raw material of Chinese medicine by preceding method: it is made raw materials of effective components and forms and to be by weight ratio---10 parts of Radix Peucedanis, 15 parts of the Radix Paeoniae Albas, 10 parts of Ramulus Cinnamomi, 30 parts of the Radixs Astragali, 30 parts of Radix Codonopsis, 10 parts of Rhizoma Chuanxiongs, 18 parts of Pheretimas, 10 parts of Radix Platycodoniss, quench the thirst 10 parts, 8 parts of the Rhizoma Pinelliaes, 15 parts of Radix Scutellariaes, 22 parts in Gypsum Fibrosum, 6 parts in Radix Glycyrrhizae, 10 parts of Poria, 10 parts of the Radixs Angelicae Dahuricae, 20 parts of Radix Angelicae Sinensis, 10 parts in Semen Armeniacae Amarum, 10 parts of Cortex Magnoliae Officinalis, 10 parts of Pericarpium Citri Reticulataes, 15 parts of Fructus Perillaes, 1 part of Gecko, 12 parts of Bombyx Batryticatus, 15 parts of Fructus Forsythiaes, 10 parts of Flos Magnoliaes, 15 parts of Rhizoma Belamcandae, 15 parts of Fructus Schisandrae Chinensis, 15 parts of Fructus Psoraleaes, 10 parts of tea rich in selenium, 15 parts of Radix Tripterygii Wilfordiis, 25 parts of Semen Coiciss, 15 parts of Radix Morindae Officinaliss, 6 parts of Herba Ephedrae (processed), 20 parts of Flos Loniceraes, 25 parts of Herba Houttuyniae.
Its manufacture process is as follows:
After in the GMP10000 level toilet nanometer raw material of Chinese medicine being mixed according to the above ratio, " Chinese pharmacopoeia Chinese medicine part preparation capsule standard is not added adjuvant, antiseptic, does not granulate to adopt latest edition, it is encapsulated to adopt the fully-automatic capsule filling machine to divide, and makes capsule.After finishing, Production and Packaging unify instantaneously sterilising by production batch.Every content of dispersion is the 0.2-0.5 gram, and the patient takes the 1-6 grain at every turn, and respectively obey 1 early, middle and late, night every day.
" embodiment two "
Prepare the nanometer raw material of Chinese medicine by preceding method: it is made raw materials of effective components and forms and to be by weight ratio---10 parts of Radix Peucedanis, 15 parts of the Radix Paeoniae Albas, 10 parts of Ramulus Cinnamomi, 30 parts of the Radixs Astragali, 30 parts of Radix Codonopsis, 10 parts of Rhizoma Chuanxiongs, 18 parts of Pheretimas, 10 parts of Radix Platycodoniss, quench the thirst 10 parts, 8 parts of the Rhizoma Pinelliaes, 15 parts of Radix Scutellariaes, 22 parts in Gypsum Fibrosum, 6 parts in Radix Glycyrrhizae, 10 parts of Poria, 10 parts of the Radixs Angelicae Dahuricae, 20 parts of Radix Angelicae Sinensis, 10 parts in Semen Armeniacae Amarum, 10 parts of Cortex Magnoliae Officinalis, 10 parts of Pericarpium Citri Reticulataes, 15 parts of Fructus Perillaes, 1 part of Gecko, 12 parts of Bombyx Batryticatus, 15 parts of Fructus Forsythiaes, 10 parts of Flos Magnoliaes, 15 parts of Rhizoma Belamcandae, 15 parts of Fructus Schisandrae Chinensis, 15 parts of Fructus Psoraleaes, 10 parts of tea rich in selenium, 15 parts of Radix Tripterygii Wilfordiis, 25 parts of Semen Coiciss, 15 parts of Radix Morindae Officinaliss, 6 parts of Herba Ephedrae (processed), 20 parts of Flos Loniceraes, 25 parts of Herba Houttuyniae.
Its manufacture process is as follows:
After in the GMP10000 level toilet nanometer raw material of Chinese medicine being mixed according to the above ratio, adopt latest edition " Chinese pharmacopoeia Chinese medicine part preparation oral solution standard, do not add adjuvant, routine decocts into the decoction (being to contain the 4g crude drug in the 4mL decoction) of 550mL, puts into 60% sugar and micro-antiseptic again and makes syrup.After finishing, Production and Packaging unify instantaneously sterilising by production batch.Every 4mL content of dispersion is a 4-5 gram, and the patient takes 1 at every turn, and respectively obey 1 early, middle and late, night every day.
" embodiment three "
Prepare the nanometer raw material of Chinese medicine by preceding method: it is made raw materials of effective components and forms and to be by weight ratio---10 parts of Radix Peucedanis, 15 parts of the Radix Paeoniae Albas, 10 parts of Ramulus Cinnamomi, 30 parts of the Radixs Astragali, 30 parts of Radix Codonopsis, 10 parts of Rhizoma Chuanxiongs, 18 parts of Pheretimas, 10 parts of Radix Platycodoniss, quench the thirst 10 parts, 8 parts of the Rhizoma Pinelliaes, 15 parts of Radix Scutellariaes, 22 parts in Gypsum Fibrosum, 6 parts in Radix Glycyrrhizae, 10 parts of Poria, 10 parts of the Radixs Angelicae Dahuricae, 20 parts of Radix Angelicae Sinensis, 10 parts in Semen Armeniacae Amarum, 10 parts of Cortex Magnoliae Officinalis, 10 parts of Pericarpium Citri Reticulataes, 15 parts of Fructus Perillaes, 1 part of Gecko, 12 parts of Bombyx Batryticatus, 15 parts of Fructus Forsythiaes, 10 parts of Flos Magnoliaes, 15 parts of Rhizoma Belamcandae, 15 parts of Fructus Schisandrae Chinensis, 15 parts of Fructus Psoraleaes, 10 parts of tea rich in selenium, 15 parts of Radix Tripterygii Wilfordiis, 25 parts of Semen Coiciss, 15 parts of Radix Morindae Officinaliss, 6 parts of Herba Ephedrae (processed), 20 parts of Flos Loniceraes, 25 parts of Herba Houttuyniae.
Its manufacture process is as follows:
After in the GMP10000 level toilet nanometer raw material of Chinese medicine being mixed according to the above ratio, " Chinese pharmacopoeia Chinese medicine part preparation membrane standard, filmogen adopts polyvinyl alcohol, makes medicine film in the nanometer to adopt latest edition.After finishing, Production and Packaging unify instantaneously sterilising by production batch.Every membrane area size is the 1-98 square centimeter, and content of dispersion is the 1.2-55 gram, and every medicine film pasted 12-96 hour, pasted the medicine position: acupuncture points such as neck, chest, back part, abdominal part, shank, foot bottom, Ashi point.
Claims (10)
1. treat bronchial asthma nanometer Chinese medicine and technology of preparing for one kind, it is characterized in that: this prescription raw materials of effective components and weight proportion---
Radix Peucedani 8-16 part, Radix Paeoniae Alba 10-20 part, Ramulus Cinnamomi 8-16 part, Radix Astragali 20-40 part, Radix Codonopsis 20-40 part, Rhizoma Chuanxiong 8-16 part, Pheretima 15-30 part, Radix Platycodonis 8-16 part, the 8-16 part of quenching the thirst, Rhizoma Pinelliae 6-12 part, Radix Scutellariae 10-20 part, Gypsum Fibrosum 20-30 part, Radix Glycyrrhizae 5-10 part, Poria 8-16 part, Radix Angelicae Dahuricae 8-16 part, Radix Angelicae Sinensis 13-30 part, Semen Armeniacae Amarum 8-16 part, Cortex Magnoliae Officinalis 8-16 part, Pericarpium Citri Reticulatae 8-16 part, Fructus Perillae 10-20 part, Gecko 1-2 part, Bombyx Batryticatus 10-20 part, Fructus Forsythiae 10-20 part, Flos Magnoliae 8-16 part, Rhizoma Belamcandae 10-20 part, Fructus Schisandrae Chinensis 10-20 part, Fructus Psoraleae 10-20 part, tea rich in selenium 8-16 part, Radix Tripterygii Wilfordii 10-20 part, Semen Coicis 20-40 part, Radix Morindae Officinalis 10-20 part, Herba Ephedrae (processed) 5-10 part, Flos Lonicerae 15-30 part, Herba Houttuyniae 20-40 part.
2. a kind of treatment bronchial asthma nanometer Chinese medicine according to claim 1 and technology of preparing, it is characterized in that: the weight proportion of described each raw material is---
Radix Peucedani 8-15 part, Radix Paeoniae Alba 12-18 part, Ramulus Cinnamomi 8-12 part, Radix Astragali 25-35 part, Radix Codonopsis 25-35 part, Rhizoma Chuanxiong 8-12 part, Pheretima 15-25 part, Radix Platycodonis 8-12 part, the 8-12 part of quenching the thirst, Rhizoma Pinelliae 6-10 part, Radix Scutellariae 12-18 part, Gypsum Fibrosum 20-25 part, Radix Glycyrrhizae 5-8 part, Poria 8-12 part, Radix Angelicae Dahuricae 8-12 part, Radix Angelicae Sinensis 18-25 part, Semen Armeniacae Amarum 8-12 part, Cortex Magnoliae Officinalis 8-12 part, Pericarpium Citri Reticulatae 8-12 part, Fructus Perillae 10-18 part, Gecko 1-1.5 part, Bombyx Batryticatus 10-15 part, Fructus Forsythiae 12-18 part, Flos Magnoliae 8-12 part, Rhizoma Belamcandae 12-18 part, Fructus Schisandrae Chinensis 12-18 part, Fructus Psoraleae 12-18 part, tea rich in selenium 8-12 part, Radix Tripterygii Wilfordii 12-18 part, Semen Coicis 20-30 part, Radix Morindae Officinalis 12-18 part, Herba Ephedrae (processed) 5-8 part, Flos Lonicerae 15-25 part, Herba Houttuyniae 20-30 part.
3. a kind of treatment bronchial asthma nanometer Chinese medicine according to claim 1 and 2 and technology of preparing is characterized in that: the preferable weight proportion of described each raw material is---
10 parts of Radix Peucedanis, 15 parts of the Radix Paeoniae Albas, 10 parts of Ramulus Cinnamomi, 30 parts of the Radixs Astragali, 30 parts of Radix Codonopsis, 10 parts of Rhizoma Chuanxiongs, 18 parts of Pheretimas, 10 parts of Radix Platycodoniss, quench the thirst 10 parts, 8 parts of the Rhizoma Pinelliaes, 15 parts of Radix Scutellariaes, 22 parts in Gypsum Fibrosum, 6 parts in Radix Glycyrrhizae, 10 parts of Poria, 10 parts of the Radixs Angelicae Dahuricae, 20 parts of Radix Angelicae Sinensis, 10 parts in Semen Armeniacae Amarum, 10 parts of Cortex Magnoliae Officinalis, 10 parts of Pericarpium Citri Reticulataes, 15 parts of Fructus Perillaes, 1 part of Gecko, 12 parts of Bombyx Batryticatus, 15 parts of Fructus Forsythiaes, 10 parts of Flos Magnoliaes, 15 parts of Rhizoma Belamcandae, 15 parts of Fructus Schisandrae Chinensis, 15 parts of Fructus Psoraleaes, 10 parts of tea rich in selenium, 15 parts of Radix Tripterygii Wilfordiis, 25 parts of Semen Coiciss, 15 parts of Radix Morindae Officinaliss, 6 parts of Herba Ephedrae (processed), 20 parts of Flos Loniceraes, 25 parts of Herba Houttuyniae.
4. according to claim 1 or 2 or 3 any described a kind of treatment bronchial asthma nanometer Chinese medicine and technologies of preparing, it is characterized in that: adopt sun greater than yin, yang six cloudy four theoretical research and development Ben Nami Chinese medicines.Said nanometer Chinese medicine had both contained Chinese medicine extract nanometer dry powder, contained Chinese medicine water drug-decocting concentrating liquid nanometer dry powder again.Final products of the present invention can be tablet, pill, powder, suppository, granule, membrane, capsule, microcapsule, effervescent, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution, plaster.
5. according to claim 1 or 2 or 3 any described a kind of treatment bronchial asthma nanometer Chinese medicine and technologies of preparing, it is characterized in that: said medicine is rich in the nanometer organic selenium, the present invention prescription is taken in four time periods of every day respectively by midnight-noon and ebb-flow doctrine energy and blood of human body flowing law, by different time stick at body local skin, the treatment of acupuncture point administration Transdermal absorption.
6. treat bronchial asthma nanometer Chinese medicine and technology of preparing for one kind, it is characterized in that may further comprise the steps:
Step 1: pretreatment, get the common Chinese decoction pieces of respectively distinguishing the flavor of, each flavor Chinese medicine is inserted pulverizer respectively be crushed to the 80-200 order, adopt supersonic airstream to be crushed to the 1-10 micron then, get each Chinese medicine micropowder, standby.
Step 2: get 25% each Chinese medicine micropowder, extract pulverizing with high-frequency ultrasonic respectively, ultrasonic power is: 1500W-3000W, supersonic frequency: 28KHz--120KHz, to pulverize extraction time be 10-100 minute.Get each Chinese medicine extract, standby.
Step 3: get 25% each Chinese medicine micropowder, carry out various medicines with microwave extracting respectively and propose extraction, microwave power is set under the 40--80% (1000 watts of peak powers), make solvent with 38%--45% ethanol, solvent 25-35 doubly measures, pressure 0.10-0.25Mpa, constant voltage time 30-60 can obtain dissolution rate preferably second.Get each Chinese medicine extract, standby.
Step 4: get each Chinese medicine micropowder of 40% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges and filters, and filtrate concentrates, and gets water drug-decocting concentrating liquid with standby.
Step 5: adopt supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) spray drying to be crushed to the 1-5 micron grain size respectively above-mentioned each Chinese medicine extract and water drug-decocting concentrating liquid.Get each Chinese medicine extract micron order dry powder.
Step 6: get Chinese medicine micropowder and above-mentioned each Chinese medicine extract micron order dry powder of 10%, adopt the swing nanon ball-mill of independent research to grind respectively 4-16 hour, obtain particle size distribution and be the various Chinese medicine nano powders of 50-1000 nanometer, standby.
Step 7: in GMP10000 level toilet, above-mentioned various Chinese medicine nano powders are mixed by described Billy.
Step 8: in GMP10000 level toilet, make aforementioned various preparation by version Chinese Pharmacopoeia second portion standard preparation standard in 2005.
Step 9: each formulation products is pasted labeling respectively, played exterior and interior packings such as sign indicating number, vanning.
Step 10: packaged product carries out instantaneously sterilising respectively by production batch, and opens the sterilization report.
7. a kind of treatment bronchial asthma nanometer Chinese medicine according to claim 6 and technology of preparing is characterized in that: described step 2 is being carried out in the leaching process with high-frequency ultrasonic, can carry out the dispersion and the pulverizing of powder simultaneously.
8. a kind of treatment bronchial asthma nanometer Chinese medicine according to claim 7 and technology of preparing is characterized in that: described step 3 is carried out various medicines with microwave extracting and is carried when extraction, can collect volatile active substance in the medicine simultaneously.
9. a kind of treatment bronchial asthma nanometer Chinese medicine according to claim 8 and technology of preparing, it is characterized in that: described step 6 is carried out nano-milled with the swing nanon ball-mill of independent research, be with the powder ball grinder of bacterium of going out of packing into, ground 4～16 hours with swing nanon ball-mill.60～80 degrees centigrade the high temperature that produces when grinding with the swing nanon ball-mill of independent research simultaneously, can carry out high temperature sterilize to raw material.
10. a kind of treatment bronchial asthma nanometer Chinese medicine according to claim 9 and technology of preparing; it is characterized in that: the described protection domain of this claim is not only described preparation method and technology; as required, be also included within add on its basis or use other better effects if, more economical, upgrade, more advanced preparation method and technology.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102631962A CN102100856A (en) | 2009-12-17 | 2009-12-17 | Nano traditional Chinese medicine for treating bronchial asthma and preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102631962A CN102100856A (en) | 2009-12-17 | 2009-12-17 | Nano traditional Chinese medicine for treating bronchial asthma and preparation technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102100856A true CN102100856A (en) | 2011-06-22 |
Family
ID=44154056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009102631962A Pending CN102100856A (en) | 2009-12-17 | 2009-12-17 | Nano traditional Chinese medicine for treating bronchial asthma and preparation technology |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102100856A (en) |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247586A (en) * | 2011-07-23 | 2011-11-23 | 长治市郊区黄碾镇中心卫生院 | Medicine for treating asthma and preparation method thereof |
| CN102370863A (en) * | 2011-11-22 | 2012-03-14 | 王洪强 | Traditional Chinese medicine for treating bronchial asthma |
| CN102671155A (en) * | 2012-04-18 | 2012-09-19 | 王桂琴 | Medicine for treating asthma and preparation method of medicine |
| CN102846934A (en) * | 2011-06-30 | 2013-01-02 | 苏州知微堂生物科技有限公司 | Preparation technology and production method for an integrated new formulation of warming channel decoction |
| CN102847122A (en) * | 2012-09-19 | 2013-01-02 | 李承平 | Schisandra chinensis, ginger and asarum pill |
| CN102846935A (en) * | 2011-06-30 | 2013-01-02 | 苏州知微堂生物科技有限公司 | Preparation technology and production method for an integrated new formulation of fluid-increasing decoction |
| CN103432295A (en) * | 2013-09-05 | 2013-12-11 | 于晓燕 | Traditional Chinese medicine for treating chronic bronchitis |
| CN103462030A (en) * | 2013-07-18 | 2013-12-25 | 浙江劲膳美生物科技有限公司 | Special diet for people with phlegm-dampness constitution |
| CN103599332A (en) * | 2013-11-19 | 2014-02-26 | 太和县中医院 | Traditional Chinese medicine for treating acute bronchitis |
| CN103599431A (en) * | 2013-10-31 | 2014-02-26 | 陈维娜 | Traditional Chinese medicine formula for treating cardiac asthma |
| CN103877318A (en) * | 2014-03-22 | 2014-06-25 | 李双双 | Traditional Chinese medicinal composition for treating asthma |
| CN103877518A (en) * | 2014-04-11 | 2014-06-25 | 王家玲 | Traditional Chinese medicine for treating bronchitis |
| CN103893737A (en) * | 2014-04-23 | 2014-07-02 | 王林 | Medicament used for treating bronchial asthma and preparation method thereof |
| CN104013864A (en) * | 2014-05-20 | 2014-09-03 | 王伟伟 | Traditional Chinese medicine composition for treating bronchitis |
| EP2758020A4 (en) * | 2011-08-05 | 2016-03-30 | Angiosome Inc | Therapeutic garment, apparatus, method, and system having inflatable bladders |
| WO2017016088A1 (en) * | 2015-07-30 | 2017-02-02 | 济南正骐生物科技有限公司 | Traditional chinese medicine treating allergic asthma and preparation method thereof |
| CN111773308A (en) * | 2020-04-07 | 2020-10-16 | 李瑞玉 | Traditional Chinese medicine composition of 'lung-ventilating and toxin-expelling decoction' for preventing and treating new coronary pneumonia and preparation method |
-
2009
- 2009-12-17 CN CN2009102631962A patent/CN102100856A/en active Pending
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846935A (en) * | 2011-06-30 | 2013-01-02 | 苏州知微堂生物科技有限公司 | Preparation technology and production method for an integrated new formulation of fluid-increasing decoction |
| CN102846934A (en) * | 2011-06-30 | 2013-01-02 | 苏州知微堂生物科技有限公司 | Preparation technology and production method for an integrated new formulation of warming channel decoction |
| CN102247586A (en) * | 2011-07-23 | 2011-11-23 | 长治市郊区黄碾镇中心卫生院 | Medicine for treating asthma and preparation method thereof |
| EP2758020A4 (en) * | 2011-08-05 | 2016-03-30 | Angiosome Inc | Therapeutic garment, apparatus, method, and system having inflatable bladders |
| CN102370863A (en) * | 2011-11-22 | 2012-03-14 | 王洪强 | Traditional Chinese medicine for treating bronchial asthma |
| CN102671155B (en) * | 2012-04-18 | 2015-06-24 | 王桂琴 | Medicine for treating asthma and preparation method of medicine |
| CN102671155A (en) * | 2012-04-18 | 2012-09-19 | 王桂琴 | Medicine for treating asthma and preparation method of medicine |
| CN102847122A (en) * | 2012-09-19 | 2013-01-02 | 李承平 | Schisandra chinensis, ginger and asarum pill |
| CN103462030A (en) * | 2013-07-18 | 2013-12-25 | 浙江劲膳美生物科技有限公司 | Special diet for people with phlegm-dampness constitution |
| CN103432295B (en) * | 2013-09-05 | 2015-03-18 | 于晓燕 | Traditional Chinese medicine for treating chronic bronchitis |
| CN103432295A (en) * | 2013-09-05 | 2013-12-11 | 于晓燕 | Traditional Chinese medicine for treating chronic bronchitis |
| CN103599431A (en) * | 2013-10-31 | 2014-02-26 | 陈维娜 | Traditional Chinese medicine formula for treating cardiac asthma |
| CN103599431B (en) * | 2013-10-31 | 2015-12-02 | 陈维娜 | A kind of Chinese medicine composition for the treatment of cardiac asthma |
| CN103599332A (en) * | 2013-11-19 | 2014-02-26 | 太和县中医院 | Traditional Chinese medicine for treating acute bronchitis |
| CN103599332B (en) * | 2013-11-19 | 2016-04-13 | 太和县中医院 | A kind of Chinese medicine for the treatment of acute bronchitis |
| CN103877318A (en) * | 2014-03-22 | 2014-06-25 | 李双双 | Traditional Chinese medicinal composition for treating asthma |
| CN103877518A (en) * | 2014-04-11 | 2014-06-25 | 王家玲 | Traditional Chinese medicine for treating bronchitis |
| CN103893737A (en) * | 2014-04-23 | 2014-07-02 | 王林 | Medicament used for treating bronchial asthma and preparation method thereof |
| CN104013864A (en) * | 2014-05-20 | 2014-09-03 | 王伟伟 | Traditional Chinese medicine composition for treating bronchitis |
| WO2017016088A1 (en) * | 2015-07-30 | 2017-02-02 | 济南正骐生物科技有限公司 | Traditional chinese medicine treating allergic asthma and preparation method thereof |
| CN111773308A (en) * | 2020-04-07 | 2020-10-16 | 李瑞玉 | Traditional Chinese medicine composition of 'lung-ventilating and toxin-expelling decoction' for preventing and treating new coronary pneumonia and preparation method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102100856A (en) | Nano traditional Chinese medicine for treating bronchial asthma and preparation technology | |
| CN101658631A (en) | Drug for treating chronic bronchitis and pulmonary emphysema | |
| CN101181393A (en) | Chinese medicine preparation for curing common cold and producing method thereof | |
| CN102772778A (en) | Chinese medicinal composition for treating summer heat-dampness | |
| CN101985028A (en) | Chinese medicinal composition for treating gastritis | |
| CN102048893A (en) | Traditional Chinese medicine composition for treating arthromyodynia | |
| CN101912596B (en) | Medicament for treating allergic rhinitis and preparation method thereof | |
| CN101138613A (en) | Traditional Chinese medicine for treating acute bronchitis of children | |
| CN105833179A (en) | Traditional Chinese medicine for treating nonalcoholic steatohepatitis | |
| CN102327502A (en) | Chinese medicament capsule for treating tracheitis | |
| CN106539908A (en) | A kind of Chinese medicine composition for treating allergic rhinitises and skin allergy | |
| CN101905013B (en) | Health care wine for treating gastropathy | |
| CN101249255A (en) | Proprietary Chinese medicine for curing children's cough and method of preparing the same | |
| CN100430085C (en) | Medicine for ventilating the lung and resolving phlegm to relieve cough and preparing method | |
| CN105617146A (en) | Traditional Chinese medicine composition for preventing and treating infantile recurrent respiratory tract infection and preparation method thereof | |
| CN105535193A (en) | Traditional Chinese medicine beverage capable of relaxing bowels | |
| CN105056170A (en) | Application of traditional Chinese medicine composition in preparing drug for treating acute gastritis | |
| CN104758466A (en) | Traditional Chinese medicine preparation for treating acute cholecystitis and preparation method of traditional Chinese medicine preparation | |
| CN1698848A (en) | Medicine with cough and asthma stopping and lung moistening functions and its preparation process | |
| CN102100814A (en) | Method for preparing nanometer traditional Chinese medicine for treating severe asthma and production method thereof | |
| CN104721767A (en) | Chinese medicinal composition for treatment of children cough and preparation method thereof | |
| CN104162127A (en) | Traditional Chinese medicinal preparation for curing heart failure | |
| CN106166251A (en) | A kind of for Chinese medicine preparation treating asthma and preparation method thereof | |
| CN106266962A (en) | A kind of medicament composing prescription for the nursing of puerpera's postpartum depression and preparation method | |
| CN105770815A (en) | Folium artemisiae argyi-containing traditional Chinese medicine composition for treating postpartum collapse and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110622 |