CN100430085C - Medicine for ventilating the lung and resolving phlegm to relieve cough and preparing method - Google Patents
Medicine for ventilating the lung and resolving phlegm to relieve cough and preparing method Download PDFInfo
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Abstract
The present invention discloses a prescription, a prescription quantity and a preparation process of a traditional Chinese medicine preparation which has the functions for cleaning and promoting the dispersing function of the lung, eliminating phlegm and stopping cough. The traditional Chinese medicine is prepared from stemona root, loquat leaf, hogfenneL root, rehmannia root, bitter apricot seed, schisandra fruit, dwarf lilyturf tuber, fritillaria thunbergii and the licorice traditional Chinese medicine. In the nine kinds of medicine, the fritillaria thunbergii is pulverized into fine powder and is reserved; 80% of ethanol is added to the bitter apricot seed, the hogfenneL root and the schisandra fruit, and the ethanol is extracted for two times; ethanol whose quantity is 8 times of that of the 80% of ethanol is added for each time, and the extraction is carried out for 2 hours; an extracting solution is merged and filtered, the ethanol is recovered from the filtrate, the filtrate is concentrated into clear paste whose relative density is from 1.25 to 1.30 (60 DEG C), and the clear paste is reserved; water is added to the dregs and the rest five kinds of medicine, such as the stemona root, etc., the mixture is decocted for three times, and 8 times of water in quantity is added to the mixture for each time; the decoction is carried out for 1.5 hours, and a decoction solution is merged and filtered; the filtrate is concentrated into clear paste whose relative density is from 1.25 to 1.30 (60 DEG C); the clear paste is uniformly mixed with the clear paste and the fine powder, the mixture is dried, pulverized, made into granules and encapsulated, and 1000 capsules are made, so that the traditional Chinese medicine preparation is obtained. Clinical experiments prove that the traditional Chinese medicine can effectively clear away heat and toxic materials, dispel wind and relieve exterior syndromes, and can be used for cold wind heat syndromes which appear as obvious.
Description
Technical field
The present invention relates to the Chinese medicine formulation art, especially relate to a kind of medicine for the treatment of row cleaning lung qi dispersing, preventing phlegm from forming and stopping coughing and preparation method thereof.
Background technology
Cough is one of main syndrome of lung pattern disease.The exogenous cough is very common clinically disease, and sickness rate is higher, and Susceptible population is wide, with climate change substantial connection is arranged, and affection of exogenous wind-cold fails in time to cure wind and cold heat-transformation, dryness-transformation impairing the lung, impairment of purifying and descending function of the lung; Thermal burn lung Tianjin, expectorant heat stop up to stagnate increases the weight of characteristic of disease, is difficult for curing.This prescription is formed with Chinese medicines such as the Radix Stemonae, Semen Armeniacae Amarum, Bulbus Fritillariae Thunbergii Radix Peucedani, Radix Ophiopogonis, Radix Rehmanniae, Fructus Schisandrae Chinensis, Radix Glycyrrhizaes, has the lung qi dispersing heat clearing away, the effect of relieving cough and resolving phlegm.The card of main treatment wind-dryness impairing the lung, how on the books the effect of said medicine treatment assertive evidence is in the ancient mat of Chinese medicine document.
The Radix Stemonae
(Mingyi Bielu): " main cough with dyspnea ".
{ property of medicine book on Chinese herbal medicine }: " controlling lung-heat, lung moistening ".
(book on Chinese herbal medicine justice): " though Radix Stemonae tepor so embellish but not dry, and can the using pungent drugs for dispersion and bitter drugs for purgation sending down the abnormal ascending QI, all coughing and do not have unsuitable it, and the essential good medicine of chronic cough particularly ".
(modern study)
1, (-)-Stemoninine can reduce the animal breath central excitation, suppresses coughre flex and has antitussive effect.
2, clinical pulmonary tuberculosis, pertussis, the chronic tracheitis of being used for the treatment of.
Semen Armeniacae Amarum
(property of medicine book on Chinese herbal medicine): " main cough with dyspnea dyspnea with rapid and short breath is gone into Radix Asparagi and is fried in shallow oil, the profit cardiopulmonary.”
(pearl sac): " remove lung-heat, control part of the body cavity above the diaphragm housing the heart and lungs wind heat, sharp chest and diaphragm QI rising in reverse order, profit large intestine constipation due to disorder of QI.”
Bulbus Fritillariae Thunbergii
(Mingyi Bielu): " treat cough with dyspnea, only dysphoria with smothery sensation is thirsty, perspires.”
(herbal classic is met former): " lung is subjected to pericardium superior, thereby gives birth to expectorant, or is done by pathogenic heat, breathes heavily the unhappiness of coughing, and non-this is not controlled.”
(modern study)
1, pharmacological research: Bulbus Fritillariae Thunbergii has antitussive, effects such as blood pressure lowering.
2, clinical the Bulbus Fritillariae Thunbergii flower is made fluid extract, treatment upper respiratory tract infection and chronic inflammation.
Radix Peucedani
(Mingyi Bielu): " expectorant is full, painful abdominal mass in the breast side of body, and stagnation of QI in chest and abdomen, wind headache goes the expectorant therapeutic method to keep the adverse QI flowing downwards, and cold and heat cure the wound.”
(property of medicine book on Chinese herbal medicine): " the inside and outside all heat of the reality of reducing phlegm and internal heat and seasonal epidemic pathogens ".
(Compendium of Materia Medica): " clearing away lung-heat, the heat of reducing phlegm, the ailment said due to cold or exposure of loosing.”
(herbal classic is met former): " its merit is longer than the therapeutic method to keep the adverse QI flowing downwards, coughs so can control the expectorant dyspnea of heat type, and all diseases of painful abdominal mass diaphragm, the next inflammation of gas is fallen, and expectorant also falls, and is will distinguishing the flavor of of mental disorder, the inside and outside all heat of cure the wound cold cold and heat and seasonal epidemic pathogens.”
(modern study)
Pharmacological evaluation: phlegm-dispelling functions is preferably arranged.Resisiting influenza virus and fungi activity are arranged.
Radix Ophiopogonis
(book on Chinese herbal medicine converges and says): " Radix Ophiopogonis, the medicine of clearing away heart-fire and moistening the lung.”
(book on Chinese herbal medicine newly organized): " the Radix Ophiopogonis door, the volt in the eliminating the pathogens from the lung is fiery, excess-heat in the clearing stomach ....”
Radix Rehmanniae
(book on Chinese herbal medicine meets former): " Radix Rehmanniae allusion quotation, interior special removing heat from blood YIN nourishing is moistened skin Rong Ze outward, and patient's void has hot person to add to use it.”
Fructus Schisandrae Chinensis
(herbal classic): " impairment caused by overstrain is won thin, tonifying for the deficiency, reinforcing YIN-essence, beneficial man's essence for main QI invigorating, cough with dyspnea.”
(Bencao Beiyao): " warm in nature, the five tastes are had, and acid is salty to be many, so specially restrain lung qi and kidney nourishing water, supplementing QI for promoting the production of body fluid ... peaceful loudspeaker Dingchuan, relieving thirst and restlessness.”
Radix Glycyrrhizae
(Mingyi Bielu): " warming the middle warmer and descending qi, stuffy sensation with restlessness is losed heart, and hinders dirty cough, ends
Summary of the invention
The cleaning lung qi dispersing, preventing phlegm from forming and stopping coughing.Cure mainly the wind heat dryness-transformation cough caused frequency play of lung of leaving, the dry pharyngalgia of larynx, the lip xeromycteria, it is not well to cough up phlegm, and thick sputum or thick Huang are often with nasal obstruction headache, cards such as thirsty fever of the body.
The cause of disease of cough has diseases caused by exogenous pathogenic factor, internal injury two big classes.The exogenous cough attacks for exopathogen due to the lung system, and is clinical comparatively common.The traditional Chinese medical science is thought, lung governing qi, and department breathes.Because of its cold-resistant heat, be called " tender dirty ", be subject to inside and outside heresy invasion and attack and be disease, it is respectful not normal that disease is then declared, abnormal rising of lung-QI, sending out is to cough.
The exogenous cough belongs to the domination of pathogen, for heresy is violated lung, due to sluggishness of lung-QI is not smooth, if can not in time make evil outer reaching, can further transform the wind and cold heat-transformation, the wind heat dryness-transformation, impairing the lung and lose respectful clearly, thermal burn lung Tianjin is stopped up expectorant heat and is stagnated, card is seen: cough is acute frequently, the dry pharyngalgia of larynx, lip xeromycteria, it is not well to cough up phlegm, thick sputum or thick Huang are often with nasal obstruction headache, exterior syndromes such as thirsty fever of the body.Control suitable lung qi dispersing heat clearing away, the method for preventing phlegm from forming and stopping coughing.
The invention provides a kind of medicine for the treatment of row cleaning lung qi dispersing, preventing phlegm from forming and stopping coughing and preparation method thereof.This curative effect of medication is definite, and effect has no side effect taking convenience rapidly.
The inventor of Department of Pharmacy of the present invention is according to theory of Chinese medical science and the compound Chinese medicinal preparation that develops through for many years clinical empirical summary, and adopted name is for coughing the flat capsule of gram.Medicine of the present invention is to be prepared from by acceptable excipient on the raw material of Chinese medicine of following weight parts and the pharmaceutics:
Radix Stemonae 25-75 Semen Armeniacae Amarum 18-64 Bulbus Fritillariae Thunbergii 18-64 Radix Ophiopogonis 18-58g
Radix Rehmanniae 15-65 Radix Peucedani 8-48 Fructus Schisandrae Chinensis 5-45 Radix Glycyrrhizae 5-45
We are monarch drug with the Radix Stemonae.Radix Stemonae hardship is fallen, and property is flat, and the master goes into lung meridian, and nourishing the lung to arrest cough is always for controlling the key medicine of pulmonary tuberculosis cough.Compendium of Material Medica is drawn " continuous perfect side " and is controlled cruelly and cough, and " preemergency prescriptions worth thousand gold " controls chronic cough.Essentials of Matea Medica: " cough due to lung-heat is controlled in the energy lung moistening.”
Be ministerial drug with Semen Armeniacae Amarum, Bulbus Fritillariae Thunbergii, Radix Peucedani in the side.Semen Armeniacae Amarum: hardship is let out gentle, declares sharp lung qi, and depressed lung-energy dispersing is arranged, the effect of relieving cough and resolving phlegm.Bulbus Fritillariae Thunbergii: the bitter cold using pungent drugs for dispersion and bitter drugs for purgation, the eliminating stagnation of relieving inflammation or internal heat effect is stronger, should control wind heat and attack lung, the card of phlegm-fire pent-up.Radix Peucedani: the hot hardship of loosing is fallen, lowering the adverse-rising QI and dispelling phlegm, and dispelling wind-heat is apt to fall lung qi and the saliva that eliminates the phlegm.Be applicable to the turbid heap soil or fertilizer over and around the roots lung of expectorant, lung-QI being unable to descend, expectorant is thick not well, cards such as the dyspnea with fullness of the chest feeling of stuffiness in chest.Above-mentioned Semen Armeniacae Amarum, Bulbus Fritillariae Thunbergii, Radix Peucedani three ministers share removing heat-phlegm, the lung qi dispersing therapeutic method to keep the adverse QI flowing downwards, with the principal drug assistance clearing away lung-heat, and the effect that cough-relieving is coughed.
Fang Zhongyong Radix Ophiopogonis, Radix Rehmanniae, Fructus Schisandrae Chinensis are adjuvant drug.Radix Ophiopogonis: sweet in the mouth is gone into lung, can nourishing YIN and moistening the lung and the heat clearing away of holding concurrently, be advisable with it with warm-dryness syndrome or pathogenic dryness fire-transformation the wounded.Radix Rehmanniae: clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting is controlled the cough due to lung-heat.Fructus Schisandrae Chinensis: sour in the mouth convergence, gentle YIN nourishing is gone into lung kidney two warps, can on the gas of astringing the lung, following nourishing kidney-yin is with relieving cough and relieving asthma.Last three adjuvant drugs are based on nourishing YIN and moistening the lung, assist a ruler in governing a country monarch, ministerial drug clearing away dryness heat and impairment of YIN not.
The side is a messenger drug with Radix Glycyrrhizae.The Radix Glycyrrhizae invigorating the spleen and replenishing QI, nourishing the lung to arrest cough.Because of Radix Glycyrrhizae sweet in the mouth QI invigorating lung moistening eliminating phlegm and stopping cough again, and property is flat and the efficacy of a drug is gentle, coordinating the actions of various ingredients in a prescription.
In sum, we have the lung qi dispersing heat clearing away, the effect of relieving cough and resolving phlegm.
The weight portion proportion optimization of raw material of Chinese medicine of the present invention:
The Radix Stemonae 25 Semen Armeniacae Amarums 184 Bulbus Fritillariae Thunbergiis 18 Radix Ophiopogonis 18
Radix Rehmanniae 15 Radix Peucedanis 8 Fructus Schisandrae Chinensis 5 Radix Glycyrrhizaes 5
The weight portion proportion optimization of raw material of Chinese medicine of the present invention:
The Radix Stemonae 50 Semen Armeniacae Amarums 40 Bulbus Fritillariae Thunbergiis 40 Radix Ophiopogonis 30
Radix Rehmanniae 30 Radix Peucedanis 20 Fructus Schisandrae Chinensis 15 Radix Glycyrrhizaes 15
The weight portion proportion optimization of raw material of Chinese medicine of the present invention:
The Radix Stemonae 60 Semen Armeniacae Amarums 55 Bulbus Fritillariae Thunbergiis 55 Radix Ophiopogonis 45
Radix Rehmanniae 45 Radix Peucedanis 35 Fructus Schisandrae Chinensis 30 Radix Glycyrrhizaes 30
The weight portion proportion optimization of raw material of Chinese medicine of the present invention:
The Radix Stemonae 75 Semen Armeniacae Amarums 64 Bulbus Fritillariae Thunbergiis 64 Radix Ophiopogonis 58g
Radix Rehmanniae 65 Radix Peucedanis 48 Fructus Schisandrae Chinensis 45 Radix Glycyrrhizaes 45
Medicine of the present invention can be carried according to the conventional method such as the water of this area, alcohol extraction etc. is prepared into acceptable oral preparation dosage form on any pharmaceutics.Wherein preferred tablet, capsule, granule, powder or pill.
More than nine the flavor, Bulbus Fritillariae Thunbergii is ground into fine powder; Standby: Radix Peucedani, Fructus Schisandrae Chinensis, Semen Armeniacae Amarum add 70-85% ethanol extraction 2-3 time, add pure 6-10 at every turn and doubly measure, and extract 1-2 hour, merge alcohol extract, and decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.25-1.30 (60 ℃ of survey); All the other five tastes decoctings of the Radix Stemonae boil three filtrations, and decocting liquid is concentrated into the clear paste that relative density is 1.25-1.30 (60 ℃ of survey), and technology is made acceptable oral preparation dosage form on the pharmaceutics routinely then, as capsule, tablet, granule, powder or pill.
The preparation method of medicine of the present invention is preferred:
More than nine the flavor, Bulbus Fritillariae Thunbergii is ground into fine powder; Standby: Radix Peucedani, Fructus Schisandrae Chinensis, Semen Armeniacae Amarum add 80% ethanol extraction secondary, add 8 times of amounts of alcohol at every turn, extract 2 hours, merge alcohol extract, and decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.25-1.30 (60 ℃ of survey); All the other five tastes decoctings of the Radix Stemonae boil three filtrations, and decocting liquid is concentrated into the clear paste that relative density is 1.25-1.30 (60 ℃ of survey), with above-mentioned clear paste and fine powder mixing, drying, pulverize, and incapsulate, promptly.
Both of the present invention cough the gram flat capsule
The weight portion proportion optimization of embodiment raw material of Chinese medicine of the present invention:
Embodiment 1
The Radix Stemonae 25 Semen Armeniacae Amarums 18 Bulbus Fritillariae Thunbergiis 18 Radix Ophiopogonis 18
Radix Rehmanniae 15 Radix Peucedanis 8 Fructus Schisandrae Chinensis 5 Radix Glycyrrhizaes 5
Make granule of the present invention according to a conventional method.。
Embodiment 2
The Radix Stemonae 60 Semen Armeniacae Amarums 55 Bulbus Fritillariae Thunbergiis 55 Radix Ophiopogonis 45
Radix Rehmanniae 45 Radix Peucedanis 35 Fructus Schisandrae Chinensis 30 Radix Glycyrrhizaes 30
Formulation method is made powder of the present invention routinely.
Embodiment 3
The Radix Stemonae 50 Semen Armeniacae Amarums 40 Bulbus Fritillariae Thunbergiis 40 Radix Ophiopogonis 30
Radix Rehmanniae 30 Radix Peucedanis 20 Fructus Schisandrae Chinensis 15 Radix Glycyrrhizaes 15
Make capsule of the present invention according to a conventional method.
Embodiment 4
The Radix Stemonae 75 Semen Armeniacae Amarums 64 Bulbus Fritillariae Thunbergiis 64 Radix Ophiopogonis 58g
Radix Rehmanniae 65 Radix Peucedanis 48 Fructus Schisandrae Chinensis 45 Radix Glycyrrhizaes 45
Make pill of the present invention according to a conventional method.
Embodiment 5
The Radix Stemonae 50 Semen Armeniacae Amarums 40 Bulbus Fritillariae Thunbergiis 40 Radix Ophiopogonis 30
Radix Rehmanniae 30 Radix Peucedanis 20 Fructus Schisandrae Chinensis 15 Radix Glycyrrhizaes 15
More than seven the flavor, get Endoconcha Sepiae, Endothelium Corneum Gigeriae Galli, sodium bicarbonate is ground into fine powder, and is standby; Other gets Rhizoma Corydalis and pulverizes coarse powder, adds 6 times of amounts of 80% ethanol, extracts 1.5 hours, merge alcohol extract, filter, filtrate decompression is with receiving ethanol and being concentrated into the thick paste that relative density is 1.30-1.35 (60 ℃ of survey), boil liquid with above-mentioned thick paste and fine powder, filter, filtrate is concentrated into the thick paste that relative density is 1.30-1.35 (60 ℃ of survey), with above-mentioned thick paste, and the fine powder mixing, drying, pulverize, granulate, add Mentholum fine powder and magnesium stearate, mixing, compress tablet coating, promptly.
Promptly get tablet of the present invention.
Claims (8)
1. one kind is cleaned lung qi dispersing, preventing phlegm from forming and stopping coughing medicine, it is characterized in that it is the oral formulations that is prepared from by acceptable excipient on following weight parts Chinese medicinal raw materials and the pharmaceutics:
Radix Stemonae 25-75 Semen Armeniacae Amarum 18-64 Bulbus Fritillariae Thunbergii 18-64 Radix Ophiopogonis 18-58
Radix Rehmanniae 15-65 Radix Peucedani 8-48 Fructus Schisandrae Chinensis 5-45 Radix Glycyrrhizae 5-45.
2. medicine according to claim 1 is characterized in that the weight portion proportioning of raw material of Chinese medicine is:
The Radix Stemonae 25 Semen Armeniacae Amarums 18 Bulbus Fritillariae Thunbergiis 18 Radix Ophiopogonis 18
Radix Rehmanniae 15 Radix Peucedanis 8 Fructus Schisandrae Chinensis 5 Radix Glycyrrhizaes 5.
3. medicine according to claim 1 is characterized in that the weight portion proportioning of raw material of Chinese medicine is:
The Radix Stemonae 60 Semen Armeniacae Amarums 55 Bulbus Fritillariae Thunbergiis 55 Radix Ophiopogonis 45
Radix Rehmanniae 45 Radix Peucedanis 35 Fructus Schisandrae Chinensis 30 Radix Glycyrrhizaes 30.
4. medicine according to claim 1 is characterized in that the weight portion proportioning of raw material of Chinese medicine is:
The Radix Stemonae 50 Semen Armeniacae Amarums 40 Bulbus Fritillariae Thunbergiis 40 Radix Ophiopogonis 30
Radix Rehmanniae 30 Radix Peucedanis 20 Fructus Schisandrae Chinensis 15 Radix Glycyrrhizaes 15.
5. according to each described medicine of claim 1-5, it is characterized in that: this medicine is capsule, tablet, granule, powder or pill.
6. according to each described medicine of claim 1-5, it is characterized in that: this medicine is a capsule.
7, the preparation method of each described medicine of claim 1-5 is characterized in that comprising the following steps:
More than eight the flavor, Bulbus Fritillariae Thunbergii is ground into fine powder; Standby; Radix Peucedani, Fructus Schisandrae Chinensis, Semen Armeniacae Amarum add 70-85% ethanol extraction 2-3 time, add pure 6-10 at every turn and doubly measure, and extract 1-2 hour, merge alcohol extract, decompression recycling ethanol and to be concentrated into relative density be 1.25-1.30, the clear paste of 60 ℃ of surveys; All the other four flavor decoctings of the Radix Stemonae boil three filtrations, and it is 1.25-1.30 that decocting liquid is concentrated into relative density, the clear paste of 60 ℃ of surveys, and technology is made acceptable forms on the pharmaceutics routinely then, capsule, tablet, granule, powder or pill.
8, the preparation method of the described medicine of claim 7 is characterized in that comprising the following steps:
More than eight the flavor, Bulbus Fritillariae Thunbergii is ground into fine powder; Standby; Radix Peucedani, Fructus Schisandrae Chinensis, Semen Armeniacae Amarum add 80% ethanol extraction secondary, add 8 times of amounts of alcohol at every turn, extract merging alcohol extract, decompression recycling ethanol and to be concentrated into relative density be 1.25-1.30, the clear paste of 60 ℃ of surveys 2 hours; All the other four flavor decoctings of the Radix Stemonae boil three filtrations, and it is 1.25-1.30 that decocting liquid is concentrated into relative density, and the clear paste of 60 ℃ of surveys with above-mentioned clear paste and fine powder mixing, drying, is pulverized, and incapsulates, promptly.
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| CN102283996A (en) * | 2011-07-07 | 2011-12-21 | 荣成市崖头美全口腔诊所 | Traditional Chinese medicine composite for treating xerostomia |
| CN104888071A (en) * | 2015-06-15 | 2015-09-09 | 通化万通药业股份有限公司 | Anticoughing capsule and preparing method thereof |
| CN107029159A (en) * | 2017-06-08 | 2017-08-11 | 湖南云从科技有限公司 | It is a kind of to treat oral liquid that throat swells and ache and preparation method thereof |
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| CN1579441A (en) * | 2003-08-05 | 2005-02-16 | 广东台城制药有限公司 | Cough-relieving medicine and its preparation method |
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| CN1579441A (en) * | 2003-08-05 | 2005-02-16 | 广东台城制药有限公司 | Cough-relieving medicine and its preparation method |
Non-Patent Citations (4)
| Title |
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| 中药成方制剂第10册. 25. 1995 |
| 中药成方制剂第10册. 25. 1995 * |
| 慢性支气管炎中医药治疗进展. 周勇.成都医药，第27卷第3期. 2001 |
| 慢性支气管炎中医药治疗进展. 周勇.成都医药，第27卷第3期. 2001 * |
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Application publication date: 20060308 Assignee: Tonghua Wantong Pharmaceutical Co., Ltd. Assignor: Pan Shoude Contract record no.: 2010220000010 Denomination of invention: Medicine for ventilating the lung and resolving phlegm to relieve cough and preparing method Granted publication date: 20081105 License type: Exclusive License Record date: 20100414 |
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