WO2021208335A1 - Traditional chinese medicine composition capable of removing toxins, dispelling dampness, and disinhibiting throat, and application thereof - Google Patents

Abstract

Provided is a traditional Chinese medicine composition capable of removing toxins, dispelling dampness, and disinhibiting the throat, comprising the following components in parts by mass: 15-35 parts of raw Semen Coicis, 10-15 parts of Flos Lonicerae, 10-15 parts of Folium Perillae, 10-30 parts of Radix Scrophulariae, 10-20 parts of Radix Platycodi, 15-30 parts of Radix Pseudostellariae, 5-15 parts of Rhizoma Atractylodis, and 5-15 parts of Herba Pogostemonis. The composition is used for treating asymptomatic SARS-CoV-2 infection cases, symptoms such as cough, dry throat, itchy throat, sore throat, and hoarseness caused by chronic pharyngitis, and fever, cough, dry throat, itchy throat, sore throat, hoarseness, fatigue, etc. caused by influenza and acute upper respiratory tract infections.

Description

Chinese medicinal composition for detoxification, dampness and pharyngectomy and application thereof Technical field

The invention belongs to the technical field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for detoxification, dampness, and pharyngeal relief and its application.

Background technique

Coronavirus pneumonia (Corona Virus Disease 2019, COVID-19), referred to as "new coronary pneumonia", is pneumonia caused by the 2019 novel coronavirus (SARS-CoV-2) infection. Although the domestic new crown pneumonia epidemic is basically under control, there are more and more asymptomatic infections of the new crown virus (hereinafter referred to as asymptomatic infections or SARS-CoV-2 asymptomatic infections), and asymptomatic infections are highly contagious. And there is a greater possibility of reverting to new coronary pneumonia. Therefore, screening and drug intervention for asymptomatic infections are very important and urgent.

Among the existing guidelines, the "New Coronavirus Pneumonia Diagnosis and Treatment Program (Trial Seventh Edition)" issued by the National Health Commission only records that Huoxiang Zhengqi Capsules should be taken during the medical observation period when fatigue is accompanied by gastrointestinal discomfort, fatigue and fever. Shifu takes Jinhua Qinggan Granules, Lianhua Qingwen Capsules, Shufeng Jiedu Capsules; "New Coronavirus Pneumonia Traditional Chinese Medicine Diagnosis and Treatment Manual" (Wang Qi et al., Beijing: China Traditional Chinese Medicine Publishing House, 2020) gives different diagnoses for different conditions. The traditional Chinese medicine treatment.

However, the traditional Chinese medicine treatment prescriptions given in the existing guidelines are mainly for confirmed patients with corresponding symptoms such as fever, fatigue, dry cough, sore throat, shortness of breath, and asymptomatic infections do not have the above-mentioned related clinical symptoms , Only the respiratory tract and other specimens tested positive for the pathogen of the new coronavirus. The main measures taken are centralized isolation and medical observation (see "Pneumonia Prevention and Control Plan for New Coronavirus Infection" (Third Edition)), which will not only delay the timing and delay the disease It may worsen and also cause a psychological burden to asymptomatic infected persons. Therefore, as more and more asymptomatic infections are discovered, it is very necessary to provide a drug for SARS-CoV-2 asymptomatic infections to improve the existing diagnosis and treatment plan and reduce the conversion of asymptomatic infections to SARS-CoV-2. The proportion of new coronary pneumonia eases the work pressure of medical staff.

Summary of the invention

According to one aspect of the present invention, there is provided a traditional Chinese medicine composition for detoxification, dampness and pharyngeal relieving, comprising the following components in parts by mass: 15-35 parts of raw coix seed, 10-15 parts of honeysuckle, 10-15 parts of sesame leaves, 10-30 parts of Scrophulariaceae, 10-20 parts of Platycodon grandiflorum, 15-30 parts of Radix Atractylodes, 5-15 parts of Atractylodes, 5-15 parts of Huoxiang.

Fang Zhong:

The raw coix seed clears away heat and invigorates the spleen and oozes dampness, and Huoxiang fragrant to transform turbidity. The two are the master medicine, which can remove dampness and detoxify.

Honeysuckle and Atractylodes are the main medicines. Honeysuckle clears away heat and detoxifies, and disperses lightly; Atractylodes lavandulata has the effects of clearing away heat and dampness, strengthening the spleen, and dispelling rheumatism.

Su Ye disperses to relieve the surface, promotes qi and stomach. It can not only help the production of Coix Seed, Huoxiang and Zhong, but also the honeysuckle and Atractylodes. Combination of medicines can clear heat and nourish yin, detoxify and relieve throat, and prevent Huoxiang and Cangzhu from warming and injuring yin. So Su Ye, Scrophulariaceae and Platycodon grandiflorum are all adjuvants.

Taizishen is a medicine that has the effect of invigorating the spleen, replenishing qi and strengthening the body, and supporting the poison to go out. It can reconcile various medicines, so that the whole prescription can help relieve the surface and dispel dampness without hurting the body.

Based on the principle of "wet on the upper coke, drying in the middle coke, and benefiting from the lower coke", the Chinese medicinal composition for detoxification, dampness and pharyngeal relief of the present invention is mainly aimed at the pathogenesis of wind pathogens and dampness. For similar symptoms, the treatment method is to relieve the wind and relieve the throat, dispel dampness and promote the lung. Through the combination of Coix Seed, Agastache, Atractylodes, and Su Ye, the dampness can be transformed from the triple coke and increase the way out of dampness.

The detoxification, dampness and pharyngeal medicine composition takes the throat as the main disease site and acts on the oral cavity, lungs and stomach, and aims at the SARS-CoV-2 asymptomatic infection pathogenesis characteristic of "dampness, toxicity, and deficiency", by increasing dampness Eliminating dampness, clearing away heat and detoxifying, replenishing qi and strengthening the body, each breaks down the characteristics of the disease, and provides an effective drug plan for the treatment of asymptomatic SARS-CoV-2 infections to meet the urgent need for treatment of asymptomatic infections. Demand, and improve the existing diagnosis and treatment plan.

specifically:

Raw Coix Seed is the dry mature kernel of Coix lacryma-jobi L.var.ma-yuen (Roman.) Stapf, which has the functions of invigorating the spleen, removing dampness, removing numbness and diarrhea, and clearing heat and purging pus.

Honeysuckle, Lonicera japonica Thunb., Lonicera hypoglauca Miq., Lonicera confusa DC. or Lonicera dasystyla Rehd. dry flower buds or blooming flowers, It has the effects of clearing away heat, detoxifying, and dispelling wind and heat.

Perilla frutescens (L.) Britt's dried leaves (or with twigs) are the dried leaves (or with twigs) of Perilla frutescens (L.) Britt, which has the functions of relieving the surface and dispelling cold, promoting qi and stomach.

Scrophulariaceae is the dried root of Scrophularia ningpoensis Hemsl.

Platycodon grandiflorum is the dried root of Platycodon grandiflorum (Jacq.) A.DC., a plant of the Campanulaceae family.

Pseudostellaria heterophylla (Miq.) Pax ex Pax et Hoffm. The dried roots of Pseudostellaria heterophylla (Miq.) Pax et Hoffm.

Atractylodes, is the dried rhizome of Atractylodes lancea (Thunb.) DC. or Atractylodes chinensis (DC.) Koidz. of the Compositae family.

Huoxiang is the dry above-ground part of Pogostemon cablin (Blanco) Benth.

In some embodiments, the traditional Chinese medicine composition for detoxification, dampness and pharyngectomy may preferably include the following components in parts by mass: 25-35 parts of raw coix seed, 10-15 parts of honeysuckle, 12-15 parts of sage leaves, and 10 parts of Scrophulariaceae 20 parts, 15-20 parts of Platycodon grandiflorum, 15-25 parts of Pseudostellariae, 8-12 parts of Atractylodes, 8-12 parts of Huoxiang; it can be further preferably: 30 parts of raw coix seed, 12 parts of honeysuckle, 15 parts of sesame leaves, 15 parts of Scrophulariaceae, 15 parts of Platycodon grandiflorum, 20 parts of Taizishen, 10 parts of Cangzhu, 10 parts of Huoxiang.

According to one aspect of the present invention, there is also provided a medicine containing the above-mentioned detoxification, dampness and pharyngeal medicine composition. The medicine may include a medically acceptable carrier and/or excipient.

Exemplarily, the carrier or excipient may use the carriers or excipients commonly used in the art, including but not limited to starch, lactose, glucose, sodium carboxymethyl cellulose, ethyl cellulose and methyl cellulose, malt, gelatin , Polyols (such as propylene glycol, glycerol, mannitol), compressed tablets, etc. Thus, to help improve the stability or activity of the pharmaceutical composition, or produce an acceptable mouthfeel or smell in the case of oral administration.

In some embodiments, in order to facilitate clinical administration, the traditional Chinese medicine composition for detoxification, dampness and pharyngectomy or the above-mentioned medicine can be prepared by using the existing preparation method of traditional Chinese medicine preparations, with the traditional Chinese medicine composition as the main active ingredient and mixed with a carrier or excipient. The required medicament, such as granules, tablets, capsules, powders, pills, oral solutions, oral suspensions or oral emulsions, etc.

Different pharmaceutical dosage forms can be prepared according to the prior art, exemplarily:

When the traditional Chinese medicine composition for detoxification, dampness and pharyngectomy is an oral solution, it can be prepared by the following existing methods:

Add 8 to 12 times the total mass of the raw material medicine with water, heat it to boiling, keep it slightly boiling for 1 to 2 hours, after separation, the first decoction and medicine residue are obtained; for the second time, take the product obtained after the first decoction Medicine dregs, add water equivalent to 6-10 times the total mass of the crude drug, heat it to boiling, keep it slightly boiling for 1 to 2 hours, separate to obtain the second decoction and the medicine dregs; combine the first decoction and the second decoction , That is.

Alternatively, the oral solution can also be prepared in the following manner:

Add water to submerge the raw material drug and 2-3cm higher, heat the fire to a boil, change to a slow fire, keep it slightly boiling for about 30 minutes, to obtain the first decoction and dregs; add water to the raw material, heat the fire to boiling, change to Slowly heat, keep slightly boiling for 20-30 minutes to obtain the second decoction, and combine the first decoction and the second decoction to obtain.

When the detoxification, dampness and pharyngeal medicine composition is granular, it can be prepared by the following existing methods:

Obtain the filtrate according to the above method of preparing oral solution. After the filtrate is concentrated under reduced pressure to obtain a clear ointment, maltodextrin is added to the clear ointment, and then spray-dried to obtain a dry ointment powder; then, malto paste is added to the dry ointment powder Refined to obtain a mixed powder; then, add a 90% volume fraction of ethanol-water solution to the mixed powder to obtain a soft material, sieving the soft material to obtain wet particles, and finally, dry the wet particles to obtain.

It should be noted that the preparation methods of the above-mentioned granules are only exemplary and do not limit the scope of protection of the present invention. Of course, in order to prepare the granules medicines, techniques commonly used in the art can also be used. Cite.

When the detoxification, dampness and pharyngeal medicine composition is a powder, it can be prepared by the following existing method: take the raw material components, pulverize and uniformly mix with suitable carriers or/excipients to form a dry powder. .

When the detoxification, dampness and pharyngeal medicine composition is a tablet, it can be prepared by the following existing method: take the raw material component, add the carrier or/excipient, and prepare the tablet according to the existing traditional Chinese medicine tablet preparation method Medicine; Or, the wet granules can be prepared according to the method of preparing granules, and then the wet granules can be compressed and dried to obtain the tablet medicine; or, the powder can be prepared according to the method of preparing powder, and then the excipients can be added. The tablet medicine is obtained by pressing and drying.

When the detoxification, dampness and pharyngeal medicine composition is a pill, it can be prepared by the following existing method: grinding the raw material components into a fine powder, adding a suitable carrier or/excipient, according to the existing preparation method of the traditional Chinese medicine pill Pill medicine can be prepared; alternatively, the wet granules can be prepared according to the method of preparing granules, then spherical or quasi-spherical, and dried to obtain the pill medicine; alternatively, the powder can be prepared according to the method of preparing powder, and then the excipients can be added. The medicine is made into spherical or quasi-spherical and dried to obtain pill medicine, which will not be repeated here.

According to another aspect of the present invention, there is provided the application of the above-mentioned detoxification, dampness and pharyngeal medicine composition or the application of the above-mentioned medicine in the preparation of medicines for the treatment of influenza, mainly for fever, cough, sore throat, sore throat caused by influenza Symptoms such as itching, dry throat, hoarse voice, fatigue, etc., are mainly for adults, pregnant women and children should be used under the guidance of a doctor.

In particular, the present invention also provides the application of the above-mentioned traditional Chinese medicine composition for detoxification, dampness and pharyngectomy or the above-mentioned medicine in the preparation of medicines for treating asymptomatic viral infections, especially SARS-CoV-2 asymptomatic infections. The traditional Chinese medicine composition for detoxification, dampness and pharyngectomy or the above-mentioned medicaments are mainly aimed at patients with asymptomatic SARS-CoV-2 infection, especially those with insufficient cold and heat deficiency, and those infected with the core pathogenesis of dampness blocking the lungs and stomach.

In addition, the detoxification, dampness, and pharyngeal medicine composition of the present invention or the above-mentioned drugs can also be used as drugs for treating acute upper respiratory tract infections (such as the common cold, viral pharyngitis, laryngitis, herpetic angina, etc.) and chronic pharyngitis. It can also improve the symptoms of acute upper respiratory tract infection (such as common cold, viral pharyngitis, laryngitis, herpetic angina, etc.), chronic pharyngitis, such as dry throat, itchy throat, sore throat, hoarseness and other symptoms.

When the traditional Chinese medicine composition for detoxification, dampness and pharyngectomy is used for the treatment of viral influenza or SARS-CoV-2 asymptomatic infection, it can be administered by oral or nasal feeding, giving two doses a day (each dose can be: raw coix seed 30g, honeysuckle 12g, sesame leaves 15g, Scrophulariaceae 15g, Platycodon grandiflorum 15g, Pseudosperma chinensis 20g, Atractylodes 10g, Huoxiang 10g), take 7-14 days, 7 days, 14 days for repeatable nucleic acid detection.

When the traditional Chinese medicine composition for detoxification, dampness and pharyngitis is an oral solution, an oral suspension or an oral emulsion, each dose is 150-300 ml, orally divided into 4 times.

When the detoxification, dampness, and pharyngeal medicine composition is granules, capsules or tablets, the dosage is converted to the dosage of decoction pieces and taken, for example, 1 packet each time, 2 times a day, 50-100ml of boiling water, each packet About 6-15g. Specifically, the detoxification, dampness and pharyngeal medicine composition is used as an active ingredient, and its content is 10%-90% of the weight of the medicine, and the rest are auxiliary materials such as carriers or/excipients.

When the traditional Chinese medicine composition for detoxification, dampness and pharyngitis is a powder, the dosage is converted into the dosage of decoction pieces and taken. Specifically, the detoxification, dampness and pharyngeal medicine composition is used as an active ingredient, and its content is 10%-100% of the weight of the medicament, and the rest are auxiliary materials such as carriers or/excipients.

Detailed ways

The present invention will be further described in detail below in conjunction with specific embodiments. It is worth noting that in the present invention, "asymptomatic infections", "SARS-CoV-2 asymptomatic infections", and "SARS-CoV-2 asymptomatic infections" refer to: no relevant clinical manifestations, such as fever, cough, pharynx Those who have self-perceived or clinically recognizable symptoms and signs, such as pain, but the respiratory tract and other specimens have tested positive for the pathogen of the new coronavirus.

There are two situations for asymptomatic infections: one is that they have no self-perceived or clinically recognizable symptoms and signs after 14 days of quarantine medical observation; the other is the state of "asymptomatic infection" in the incubation period.

The contents not written in the preparation method of different dosage forms of the detoxification, dampness and pharyngeal medicine of the present invention are all disclosed in the prior art and should be regarded as common knowledge in the field.

Example 1

A Chinese medicinal composition for detoxification, dampness and pharyngeal relief is prepared from the following components: 30 g of raw coix seed, 12 g of honeysuckle, 15 g of sage leaves, 15 g of scrophulariaceae, 15 g of platycodon, 20 g of radix ginseng, 10 g of atractylodes, and 10 g of ageratum.

The above-mentioned components are taken and the oral solution medicine is prepared according to the existing preparation method of traditional Chinese medicine decoction. The ratio is one dose and one dose is about 200ml.

Oral solution drugs can be prepared by the following existing methods:

Add water to submerge the raw material drug and 2-3cm higher, heat the fire to a boil, change to a slow fire, keep it slightly boiling for about 30 minutes, to obtain the first decoction and dregs; add water to the raw material, heat the fire to boiling, change to Slowly heat, keep slightly boiling for 30 minutes to obtain the second decoction, and combine the first decoction and the second decoction to obtain.

Example 2

A Chinese medicinal composition for detoxification, dampness and pharyngeal relief is prepared from the following components: 30 g of raw coix seed, 12 g of honeysuckle, 15 g of sage leaves, 15 g of scrophulariaceae, 15 g of platycodon, 20 g of radix ginseng, 10 g of atractylodes, and 10 g of ageratum.

The above-mentioned components are taken, and carriers or/excipients are added to prepare granular medicines according to the existing preparation method of traditional Chinese medicine granules.

Granules can be prepared by the following existing methods:

The filtrate was obtained according to the method of preparing the decoction in Example 1. After the filtrate was concentrated under reduced pressure to obtain a clear ointment, maltodextrin was added to the clear ointment, and then spray-dried to obtain a dry ointment powder; then, malt was added to the dry ointment powder Dextrin is used to obtain a mixed powder; then, a 90% ethanol-water solution made soft material is added to the mixed powder, and the soft material is sieved to obtain wet particles. Finally, the wet particles are dried to obtain.

The granules are divided into about 10g each package, which is convenient for clinical use and administration.

Example 3

A Chinese medicinal composition for detoxification, dampness and pharyngeal relief is prepared from the following components: raw coix seed 25g, honeysuckle 10g, sage leaves 12g, Scrophulariaceae 12g, Platycodon grandiflorum 12g, Radix Atractylodes 15g, Atractylodes Rhizome 8g, and Agastache 8g.

The above components are crushed and uniformly mixed with a suitable carrier or/excipient to form a dry powder to form a powder, which can be taken with water when taking it.

Example 4

A Chinese medicinal composition for detoxification, dampness and pharyngeal treatment is prepared from the following components: 35 g of raw coix seed, 15 g of honeysuckle, 10 g of sesame leaves, 15 g of scrophulariaceae, 16 g of platycodon, 20 g of radix ginseng, 15 g of atractylodes, 15 g of ageratum.

Taking the above components, the wet granules can be prepared according to the method of Example 2, and then the wet granules are compressed and dried to obtain the tablet medicine.

Example 5

A Chinese medicinal composition for detoxification, dampness and pharyngeal relief is prepared from the following components: 30 g of raw coix seed, 12 g of honeysuckle, 10 g of sesame leaves, 15 g of scrophulariaceae, 15 g of platycodon, 20 g of radix ginseng, 5 g of atractylodes, and 12 g of ageratum.

The above-mentioned components are ground into fine powder, a suitable carrier or/excipient is added, and a pill medicine is prepared according to the existing preparation method of traditional Chinese medicine pill.

The traditional Chinese medicine composition for detoxification, dampness and pharyngectomy can be well used for the treatment of asymptomatic SARS-CoV-2 infections, increase the rate of negative conversion of new coronavirus pathogens in specimens such as respiratory tract, and reduce the conversion of asymptomatic infections. The proportion of new coronary pneumonia, this is because:

SARS-CoV-2 asymptomatic infection belongs to the category of "epidemic disease" in traditional Chinese medicine. Its disease is caused by the exposure of the epidemic virus and the dampness of the Lingnan area. The gas phase is transmitted, because the righteousness is still strong, and the symptoms such as fever, asthma, chest suffocation, palpitations, diarrhea, fatigue, etc. are not manifested. If the righteous qi is insufficient and the qi of the epidemic disease invades the lungs and stomach, the condition may worsen during the observation and isolation period and develop new coronary pneumonia.

Therefore, the traditional Chinese medicine composition for detoxification, dampness and pharyngeal relief of the present invention uses raw Coix Seed and Huoxiang as the monarch drugs to reduce dampness and detoxification; uses honeysuckle and atractylodes as minister drugs to clear away heat, detoxify and relieve the throat, disperse and relieve the surface, invigorate the spleen and dry dampness; Take Suye, Scrophulariaceae and Platycodon grandiflorum as adjuvants to clear away heat and nourish yin, detoxify and relieve the throat; use Taizi ginseng as a medicine to invigorate the spleen, nourish the qi and strengthen the body, and support toxins for going out; to relieve the wind and relieve the throat, dispel dampness and promote the lungs. , By combining raw Coix Seed, Agastache, Atractylodes Rhizome, and Su Ye to make the wet from the triple coke and increase the way out of the wet evil.

The detoxification, dampness, and pharyngeal medicine composition takes the throat as the main disease site and acts on the oral cavity, lungs and stomach, and aims at the characteristics of SARS-CoV-2 asymptomatic infection pathogenesis of "dampness, toxicity, and deficiency". The way out of dampness and evil is to dispel dampness and promote lungs, clear away heat and detoxify, replenish qi and strengthen the body. According to the characteristics of the disease, various drugs are used to break and symptomatically provide an effective drug plan for the treatment of asymptomatic SARS-CoV-2 infections. The urgent need for the treatment of asymptomatic infections has improved the existing diagnosis and treatment programs.

In addition, the traditional Chinese medicine composition of the present invention is effective against influenza, acute upper respiratory tract infections (common cold, viral pharyngitis, laryngitis, herpetic angina, etc.), dry throat, itching, sore throat caused by chronic pharyngitis, Symptoms such as hoarseness can also improve.

What has been described above are only some embodiments of the present invention. For those of ordinary skill in the art, without departing from the inventive concept of the present invention, several modifications and improvements can be made, and these all fall within the protection scope of the present invention.

Claims (11)

1. The Chinese medicinal composition for detoxification, dampness and pharyngectomy is characterized by comprising the following components in parts by mass: 15-35 parts of raw coix seed, 10-15 parts of honeysuckle, 10-15 parts of sage leaves, 10-30 parts of Scrophulariaceae, 10-20 parts of Platycodon grandiflorum, 15-30 parts of Radix Ginseng, 5-15 parts of Atractylodes, 5-15 parts of Huoxiang.
2. The traditional Chinese medicine composition for detoxification, dampness and pharyngectomy according to claim 1, characterized in that it comprises the following components in parts by mass: 25-35 parts of raw coix seed, 10-15 parts of honeysuckle, 12-15 parts of sesame leaves, 10-20 parts of Scrophulariaceae, 15-20 parts of Platycodon grandiflorum, 15-25 parts of Radix Ginseng, 8-12 parts of Atractylodes, 8-12 parts of Huoxiang.
3. The traditional Chinese medicine composition for detoxification, dampness and pharyngeal relief according to claim 1, characterized in that it comprises the following components in parts by mass: 30 parts of raw coix seed, 12 parts of honeysuckle, 15 parts of sesame leaves, 15 parts of Scrophulariaceae, Platycodon grandiflorum 15 parts, 20 parts of Taizishen, 10 parts of Cangzhu, 10 parts of Huoxiang.
4. A medicament comprising the traditional Chinese medicine composition for detoxification, dampness, dampness and pharyngectomy according to any one of claims 1 to 3, which is characterized in that it further comprises a medically acceptable carrier and/or excipient.
5. The medicine according to claim 4, wherein the medicine is granules, tablets, capsules, powders, pills, oral solutions, oral suspensions or oral emulsions.
6. Use of the traditional Chinese medicine composition for detoxification, dampness and pharyngitis according to any one of claims 1 to 3 in the preparation of a medicine for the treatment of influenza, acute upper respiratory tract infection, and chronic pharyngitis.
7. The use of the medicine according to claim 5 in the preparation of medicines for the treatment of influenza, acute upper respiratory tract infection and chronic pharyngitis.
8. Use of the traditional Chinese medicine composition for detoxification, dampness and pharyngeal treatment according to any one of claims 1 to 3 in the preparation of a medicament for the treatment of viral asymptomatic infections.
9. The application according to claim 8, wherein the asymptomatic viral infection cases include SARS-CoV-2 asymptomatic infection cases.
10. The use of the traditional Chinese medicine composition for detoxification, dampness and pharyngeal treatment according to claim 5 in the preparation of a medicament for the treatment of asymptomatic viral infections.
11. The application according to claim 10, wherein the asymptomatic viral infection cases include SARS-CoV-2 asymptomatic infection cases.