CN115089689B - Traditional Chinese medicine composition for treating spasmodic cough as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating spasmodic cough as well as preparation method and application thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The application provides a traditional Chinese medicine composition for treating spasmodic cough, a preparation method and application thereof, belonging to the technical field of traditional Chinese medicines, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 6-12 parts of bupleurum, 6-10 parts of white peony root, 6-12 parts of fructus aurantii, 3-9 parts of liquorice, 10-15 parts of white mulberry root-bark, 10-15 parts of cortex lycii radicis, 3-6 parts of dried ginger, 6-10 parts of schisandra chinensis, 10-20 parts of reed rhizome, 6-10 parts of inula flower, 10-15 parts of bitter apricot kernel, 5-10 parts of ephedra, 6-10 parts of cicada slough and 10-15 parts of stiff silkworm. The application has better treatment effect on infantile and children spasmodic cough, can obviously improve the frequency and duration of onset of cough, reduce recurrence rate and reduce occurrence of severe symptoms, and has low cost and small side effect compared with western medicine treatment.
Description
Technical Field
The application relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating spasmodic cough, and a preparation method and application thereof.
Background
Spasmodic cough is a common pulmonary symptom of infants and children, the older the infant and children, the heavier the illness state, and the complications are easy to cause, the early stage of the symptom is very similar to the common cold symptom, the symptom is easy to be missed to treat and mistreat, the Western medicine is mainly anti-infection and symptomatic treatment, no special medicine exists yet, and the Western medicine has high cost and great side effect.
Spasmodic cough is common in clinic, the incidence rate rises year by year, the disease is often caused by various factors such as infection, allergy and the like, the disease history is long, the disease condition is easy to repeat, the life quality of the children is seriously influenced, and the conventional anti-infection and symptomatic treatment effects are not ideal. The spasmodic cough can be classified as "tussilago cough" in traditional Chinese medicine, and the clinical traditional Chinese medicine treatment can obviously improve the frequency and duration of the onset of the spasmodic cough, reduce the recurrence rate and reduce the occurrence of severe symptoms. However, since the traditional Chinese medicine treatment requires dialectical treatment, doctors have the condition of non-uniform medication for the traditional Chinese medicine treatment of most diseases. The treatment of spasmodic cough is different from the viewpoints of various doctors, the level is also uneven, the clinical curative effect is difficult to judge, in addition, a series of cough-relieving and phlegm-resolving traditional Chinese medicine preparations are applied to a considerable proportion of children patients, the traditional Chinese medicine preparations can not accurately grasp the core pathogenesis of the disease, and the treatment effect is difficult to judge.
Therefore, it is necessary to provide a traditional Chinese medicine composition for treating spasmodic cough, and a preparation method and application thereof, so as to solve the existing problems.
Disclosure of Invention
In view of the above, the application provides a traditional Chinese medicine composition for treating spasmodic cough, and a preparation method and application thereof, which can obviously improve the frequency and duration of onset of cough, reduce the recurrence rate and reduce the occurrence of severe symptoms.
In order to achieve the technical effects, the application provides a traditional Chinese medicine composition for treating spasmodic cough, and a preparation method and application thereof, and adopts the following technical scheme:
a traditional Chinese medicine composition for treating spasmodic cough comprises the following components in parts by weight: 6-12 parts of bupleurum, 6-10 parts of white peony root, 6-12 parts of fructus aurantii, 3-9 parts of liquorice, 10-15 parts of white mulberry root-bark, 10-15 parts of cortex lycii radicis, 3-6 parts of dried ginger, 6-10 parts of schisandra chinensis, 10-20 parts of reed rhizome, 6-10 parts of inula flower, 10-15 parts of bitter apricot kernel, 5-10 parts of ephedra, 6-10 parts of cicada slough and 10-15 parts of stiff silkworm.
Further, the composition comprises the following components in parts by weight: 6 parts of bupleurum, 10 parts of white peony root, 6 parts of bitter orange, 3 parts of liquorice, 10 parts of white mulberry root-bark, 10 parts of cortex lycii radicis, 5 parts of dried ginger, 6 parts of shizandra berry, 10 parts of reed rhizome, 6 parts of inula flower, 10 parts of bitter apricot seed, 5 parts of ephedra herb, 6 parts of cicada slough and 10 parts of stiff silkworm.
The preparation method of the traditional Chinese medicine composition for treating spasmodic cough comprises the following steps: weighing bupleurum, white peony root, bitter orange, liquorice, white mulberry root-bark, cortex lycii radicis, dried ginger, shizandra berry, reed rhizome, inula flower, bitter apricot seed, ephedra, cicada slough and stiff silkworm according to parts by weight, adding water, decocting for 2 times, combining the two water decoctions, filtering, and collecting filtrate to obtain the traditional Chinese medicine composition.
The application of the traditional Chinese medicine composition for treating spasmodic cough in preparing a traditional Chinese medicine preparation is characterized in that the traditional Chinese medicine preparation is prepared by adding conventional auxiliary materials into the traditional Chinese medicine composition serving as an active component.
Further, the traditional Chinese medicine preparation is decoction, oral liquid, tablets, capsules or granules;
the auxiliary materials are selected from pharmaceutically acceptable excipients, diluents, stabilizers, preservatives and flavoring agents.
Further, the traditional Chinese medicine preparation is decoction, and the specific preparation method is as follows: weighing bupleurum, white peony root, bitter orange, liquorice, white mulberry root-bark, cortex lycii radicis, dried ginger, shizandra berry, reed rhizome, inula flower, bitter apricot seed, ephedra herb, cicada slough and stiff silkworm according to parts by weight, adding water which is 2-3cm higher than decoction pieces, soaking for 20-30 minutes, boiling with strong fire, decocting with slow fire for 20-30 minutes, decocting each dose twice, extruding dregs after the second decoction, and 100-200ml decoction liquid.
Further, the traditional Chinese medicine preparation is an oral liquid, and the specific preparation method comprises the following steps: weighing bupleurum, white peony root, bitter orange, liquorice, white mulberry root-bark, cortex lycii radicis, dried ginger, shizandra berry, reed rhizome, inula flower, bitter apricot seed, ephedra herb, cicada slough and stiff silkworm according to parts by weight, adding water and decocting twice, wherein the water adding amount is 8 times and 6 times of the total weight of the medicinal materials respectively, soaking for 0.5 hour, respectively decocting for 1.5 hour and 1 hour, merging the two water decoctions, filtering, concentrating the filtrate to a liquid medicine with the relative density of 1.05-1.08g/ml at 60 ℃, adding 0.5% of sodium benzoate, cooling, filtering, stirring, encapsulating and sterilizing to obtain the sucrose-free liquid medicine.
Further, the traditional Chinese medicine preparation is a tablet, and the specific preparation method is as follows: weighing bupleurum, white peony root, bitter orange, liquorice, white mulberry root-bark, cortex lycii radicis, dried ginger, shizandra berry, reed rhizome, inula flower, bitter apricot seed, ephedra herb, cicada slough and stiff silkworm according to parts by weight, adding water and decocting twice, adding water and soaking for 0.5 hour, respectively decocting for 1.5 hours and 1 hour, merging the two water decoctions, filtering, concentrating the filtrate to obtain thick ointment with relative density of 1.35-1.40g/ml at 60 ℃, vacuum drying at the temperature of below 80 ℃, crushing 100 meshes, adding 10% microcrystalline cellulose and 1% starch slurry, granulating, drying at the temperature of 80 ℃, adding 3% magnesium stearate and 3% carboxymethyl starch sodium, uniformly mixing and pressing into tablets, and sugar coating.
Further, the traditional Chinese medicine preparation is a capsule, and the specific preparation method is as follows: weighing bupleurum, white peony root, bitter orange, liquorice, white mulberry root-bark, cortex lycii radicis, dried ginger, shizandra berry, reed rhizome, inula flower, bitter apricot seed, ephedra herb, cicada slough and stiff silkworm according to parts by weight, adding water and decocting twice, adding water and soaking for 0.5 hour, respectively decocting for 1.5 hours and 1 hour, merging the two water decoctions, filtering, concentrating the filtrate to obtain thick ointment with the relative density of 1.35-1.40g/ml at the temperature of 60 ℃, vacuum drying at the temperature of below 80 ℃, crushing 40 meshes, adding 5% microcrystalline cellulose and 5% talcum powder magnesium, uniformly mixing, and filling into capsules.
Further, the traditional Chinese medicine preparation is granules, and the specific preparation method is as follows: weighing bupleurum, white peony root, bitter orange, liquorice, white mulberry root-bark, cortex lycii radicis, dried ginger, shizandra berry, reed rhizome, inula flower, bitter apricot seed, ephedra herb, cicada slough and stiff silkworm according to parts by weight, adding water and decocting twice, adding water and soaking for 0.5 hour, respectively decocting for 1.5 hours and 1 hour, merging the two water decoctions, filtering, concentrating the filtrate to obtain thick ointment with the relative density of 1.35-1.40g/ml at 60 ℃, adding 20% dextrin, 5% stevioside, granulating with 12 meshes, drying at 80 ℃, finishing granules, and subpackaging.
The technical scheme of the application at least comprises the following beneficial effects:
1. the application takes bupleurum and white peony root as principal drugs, and the four adverse drugs of the Shang Han Lun are removed, the bupleurum is used for soothing liver and Yu Toure, the white peony root is used for nourishing blood, astringing yin and softening liver, and the two drugs are used for astringing one liter, so that the effects of dispelling stagnated heat and regulating liver qi are achieved;
fructus Aurantii, cortex Mori, cortex Lycii, herba Ephedrae, semen Armeniacae amarum, periostracum Cicadae, and Bombyx Batryticatus are used as ministerial drugs, wherein fructus Aurantii regulates qi and widens middle warmer, has sedimentation effect, and can regulate whole body qi movement with bupleuri radix; cortex Mori has effects of purging lung and relieving asthma, cortex Lycii has effects of clearing lung-heat and purging pathogenic fire, and entering lung and liver channels, and both herbs have effects of purging lung heat, purging lung and lowering adverse qi, and taking purgation and whitening; ephedra herb, herba Ephedrae, having the effect of dispersing lung qi, and semen Armeniacae amarum having the effect of descending lung qi, the two medicines are combined together to regulate lung qi, disperse and reduce blood clots, relieve cough and resolve phlegm; the cicada slough and the stiff silkworm can dispel wind, relieve spasm and stop cough, and can regulate the ascending and descending of qi-flowing, and the combination of the medicines can achieve the effects of purging lung, lowering adverse qi, reducing phlegm and regulating qi-flowing;
rhizoma phragmitis, inula flower, dried ginger and shizandra berry are used as adjuvant drugs, in the recipe, the rhizoma phragmitis clears away lung heat, the inula flower has the effects of promoting blood circulation, removing blood stasis and turbid, clearing the air passage and removing phlegm and retained fluid, and the dried ginger and shizandra berry have the effects of reducing the adverse flow of lung qi and relieving cough, and the dried ginger also has the effects of warming and drying spleen and earth;
licorice root, radix Glycyrrhizae Praeparata, has the effects of expelling phlegm, relieving cough, regulating the middle warmer, and harmonizing the drugs;
the compatibility of the medicines can play the roles of dispersing stagnated liver qi, descending qi, purging lung and resolving phlegm.
2. The application takes the theory of liver qi regulating, lung diffusing, descending and normal descending and spasmodic cough stopping as the basis, and treats the infantile cough by using the method of soothing liver, descending qi, purging lung and reducing phlegm, and simultaneously treats liver and lung, thereby effectively achieving the purposes of spasmolysis and cough relieving.
3. The application has better treatment effect on infantile and children spasmodic cough, can obviously improve the frequency and duration of onset of cough, reduce recurrence rate and reduce occurrence of severe symptoms, and has low cost and small side effect compared with western medicine treatment.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application more clear, the technical solutions of the embodiments of the present application will be clearly and completely described below. It will be apparent that the described embodiments are some, but not all, embodiments of the application. All other embodiments, which are obtained by a person skilled in the art based on the described embodiments of the application, fall within the scope of protection of the application.
Example 1
A traditional Chinese medicine composition for treating spasmodic cough is prepared from the following raw materials: 6g of bupleurum, 10g of white peony root, 6g of bitter orange, 3g of liquorice, 10g of white mulberry root-bark, 10g of cortex lycii radicis, 5g of dried ginger, 6g of shizandra berry, 10g of reed rhizome, 6g of inula flower, 10g of bitter apricot seed, 5g of ephedra herb, 6g of cicada slough and 10g of stiff silkworm.
The Chinese medicinal composition can be prepared into decoction, and the specific preparation method comprises the following steps of:
weighing bupleuri radix, radix Paeoniae alba, fructus Aurantii, glycyrrhrizae radix, cortex Mori, cortex Lycii, zingiberis rhizoma, fructus Schisandrae, rhizoma Phragmitis, inulae flos, semen Armeniacae amarum, herba Ephedrae, periostracum Cicadae, and Bombyx Batryticatus, adding water 2-3cm higher than the surface of the medicinal materials, soaking for 30min, boiling with strong fire, decocting with slow fire for 30min, decocting for 2 times, mixing the decoctions, filtering, and taking for 2-3 times.
Example 2
A traditional Chinese medicine composition for treating spasmodic cough is prepared from the following raw materials: 24g of bupleurum, 20g of white peony root, 12g of bitter orange, 6g of liquorice, 20g of white mulberry root-bark, 20g of cortex lycii radicis, 10g of dried ginger, 12g of shizandra berry, 20g of reed rhizome, 12g of inula flower, 20g of bitter apricot seed, 10g of ephedra herb, 12g of cicada slough and 20g of stiff silkworm.
The traditional Chinese medicine composition can be prepared into granules, and the specific preparation method is as follows:
weighing bupleuri radix, radix Paeoniae alba, fructus Aurantii, glycyrrhrizae radix, cortex Mori, cortex Lycii, zingiberis rhizoma, fructus Schisandrae, rhizoma Phragmitis, inulae flos, semen Armeniacae amarum, herba Ephedrae, periostracum Cicadae, and Bombyx Batryticatus, soaking in 8 times of water for 0.5 hr, decocting for 1.5 hr, filtering, collecting the first decoction, adding 6 times of water into the residue, decocting for 1 hr, filtering, collecting the second decoction, mixing the two decoctions, concentrating to obtain soft extract with relative density of 1.35-1.40g/ml at 60deg.C, sequentially adding 20% dextrin and 5% stevioside according to mass fraction, mixing, sieving with 12 mesh sieve, granulating, drying at 80deg.C, grading, and packaging.
Example 3
A traditional Chinese medicine composition for treating spasmodic cough is prepared from the following raw materials: 24g of bupleurum, 20g of white peony root, 12g of bitter orange, 6g of liquorice, 20g of white mulberry root-bark, 20g of cortex lycii radicis, 10g of dried ginger, 12g of shizandra berry, 20g of reed rhizome, 12g of inula flower, 20g of bitter apricot seed, 12g of ephedra herb, 12g of cicada slough and 20g of stiff silkworm.
The traditional Chinese medicine composition can be prepared into oral liquid, and the specific preparation method is as follows:
weighing radix bupleuri, radix paeoniae alba, fructus aurantii, liquorice, cortex mori radicis, cortex lycii radicis, dried ginger, shizandra berry, reed rhizome, inula flower, bitter apricot kernel, ephedra herb, cicada slough and stiff silkworm, adding water which is 8 times of the total weight of the medicinal materials, soaking for 0.5h, decocting for 1.5h, filtering, collecting the first decoction, adding water which is 6 times of the total weight of the medicinal materials into filter residues, decocting for 1h, filtering, collecting the second decoction, combining the two decoctions, concentrating to a liquid medicine with the relative density of 1.05-1.08g/ml at 60 ℃, adding sodium benzoate with the mass fraction, cooling, filtering, uniformly stirring, encapsulating and sterilizing to obtain the Chinese medicinal preparation.
Example 4
A traditional Chinese medicine composition for treating spasmodic cough is prepared from the following raw materials: 24g of bupleurum, 20g of white peony root, 12g of bitter orange, 6g of liquorice, 20g of white mulberry root-bark, 20g of cortex lycii radicis, 6g of dried ginger, 12g of shizandra berry, 20g of reed rhizome, 12g of inula flower, 20g of bitter apricot seed, 12g of ephedra herb, 12g of cicada slough and 20g of stiff silkworm.
The Chinese medicinal composition can be prepared into tablets, and the specific preparation method comprises the following steps of:
weighing radix bupleuri, radix paeoniae alba, fructus aurantii, liquorice, cortex mori radicis, cortex lycii radicis, dried ginger, shizandra berry, reed rhizome, inula flower, bitter apricot kernel, ephedra, cicada slough and stiff silkworm, adding water which is 8 times of the total weight of the medicinal materials, soaking for 0.5h, decocting for 1.5h, filtering, collecting the first decoction, adding water which is 6 times of the total weight of the medicinal materials into filter residues, decocting for 1h, filtering, collecting the second decoction, combining the two decoctions, concentrating to a thick ointment with the relative density of 1.35-1.40g/ml at the temperature of 60 ℃, vacuum drying at the temperature of 80 ℃, crushing, sieving with a 100-mesh sieve, adding 10% microcrystalline cellulose and 1% starch slurry according to mass fraction, granulating, drying at the temperature of 80 ℃, adding 3% magnesium stearate and 3% sodium carboxymethyl starch according to mass fraction, uniformly mixing, pressing into tablets, and coating.
Example 5
A traditional Chinese medicine composition for treating spasmodic cough is prepared from the following raw materials: 3g of bupleurum, 5g of white peony root, 3g of bitter orange, 2g of liquorice, 5g of white mulberry root-bark, 5g of cortex lycii radicis, 2g of dried ginger, 3g of shizandra berry, 5g of reed rhizome, 3g of inula flower, 5g of bitter apricot seed, 3g of ephedra herb, 3g of cicada slough and 5g of stiff silkworm.
The Chinese medicinal composition can be prepared into decoction, and the specific preparation method comprises the following steps of:
weighing bupleuri radix, radix Paeoniae alba, fructus Aurantii, glycyrrhrizae radix, cortex Mori, cortex Lycii, zingiberis rhizoma, fructus Schisandrae, rhizoma Phragmitis, inulae flos, semen Armeniacae amarum, herba Ephedrae, periostracum Cicadae, and Bombyx Batryticatus, adding water 2-3cm higher than the surface of the medicinal materials, soaking for 30min, boiling with strong fire, decocting with slow fire for 30min, decocting for 2 times, mixing the decoctions, filtering, and taking for 2-3 times.
Example 6
A traditional Chinese medicine composition for treating spasmodic cough is prepared from the following raw materials: 4g of bupleurum, 6g of white peony root, 4g of bitter orange, 2g of liquorice, 6g of white mulberry root-bark, 6g of cortex lycii radicis, 2g of dried ginger, 4g of shizandra berry, 6g of reed rhizome, 4g of inula flower, 6g of bitter apricot seed, 4g of ephedra herb, 4g of cicada slough and 6g of stiff silkworm.
The Chinese medicinal composition can be prepared into decoction, and the specific preparation method comprises the following steps of:
weighing bupleuri radix, radix Paeoniae alba, fructus Aurantii, glycyrrhrizae radix, cortex Mori, cortex Lycii, zingiberis rhizoma, fructus Schisandrae, rhizoma Phragmitis, inulae flos, semen Armeniacae amarum, herba Ephedrae, periostracum Cicadae, and Bombyx Batryticatus, adding water 2-3cm higher than the surface of the medicinal materials, soaking for 30min, boiling with strong fire, decocting with slow fire for 30min, decocting for 2 times, mixing the decoctions, filtering, and taking for 2-3 times.
Example 7
A traditional Chinese medicine composition for treating spasmodic cough is prepared from the following raw materials: 9g of bupleurum, 15g of white peony root, 9g of bitter orange, 5g of liquorice, 15g of white mulberry root-bark, 15g of cortex lycii radicis, 5g of dried ginger, 9g of shizandra berry, 15g of reed rhizome, 9g of inula flower, 15g of bitter apricot seed, 9g of ephedra herb, 9g of cicada slough and 15g of stiff silkworm.
The Chinese medicinal composition can be prepared into decoction, and the specific preparation method comprises the following steps of:
weighing bupleuri radix, radix Paeoniae alba, fructus Aurantii, glycyrrhrizae radix, cortex Mori, cortex Lycii, zingiberis rhizoma, fructus Schisandrae, rhizoma Phragmitis, inulae flos, semen Armeniacae amarum, herba Ephedrae, periostracum Cicadae, and Bombyx Batryticatus, adding water 2-3cm higher than the surface of the medicinal materials, soaking for 30min, boiling with strong fire, decocting with slow fire for 30min, decocting for 2 times, mixing the decoctions, filtering, and taking for 2-3 times.
Comparative example 1
The commercially available erythromycin ethylsuccinate particles are used in combination with an atomized budesonide suspension and a terbutaline sulfate suspension.
Test example 1
1. Case selection
Clinical observation is carried out on spasmodic cough infants treated by 2021 month to 2022 month 06, and the treatment groups are randomly divided into treatment groups 1 to 7 and control group 1, wherein the average course of disease (21.94+/-12.52) of the treatment groups 1 to 7 is carried out for days, the average course of disease (19.77 +/-12.33) of the control group 1 is carried out for days, and the ages, the courses of disease and the symptoms of all the groups of cases are basically consistent, have no obvious difference and are comparable.
2. Administration method
Treatment groups 1-7: the doses of examples 1-7, respectively, were used, 1 dose daily.
Control group 1: using comparative example 1, erythromycin ethylsuccinate granules (10-12.5 mg/kg/time), oral administration was continued for 7 days 4 times daily; nebulizing budesonide suspension 1 mg/time, each 1 time in the morning and evening, terbutaline sulfate suspension 2.5 mg/time, each 1 time in the morning and evening.
3. Diagnostic basis
Reference is made to the diagnostic criteria for pediatric tussilags (spasmodic cough stage):
(1) Main symptoms are as follows: cough with light day and heavy night, red eyes, alternate nasal discharge and tear, even cough with vomiting, and roar after cough; secondary symptoms: mental fatigue, bloody sputum, epistaxis, ulceration of the tongue and laces, anorexia.
(2) The early stage of the disease may have cold-like manifestations.
(3) Tongue pulse fingerprint: a red or purple tongue with a thin, yellow or yellow greasy coating, a rapid and powerful pulse, and a purple-stagnation of the finger print can be seen in the three-joint region.
(4) The winter and spring are more than two seasons. It is suitable for infants, and has the advantages of rapid onset, and long course.
4. Observation index
The symptoms of spasmodic cough with frequent onset, duration of spasmodic cough, emesis, etc. were observed, and the symptoms were rated as 0 score, 1 score, 3 score, and 6 score according to the severity of symptoms.
5. Treatment efficacy determination
(1) Clinical recovery: cough and other symptoms disappear or disappear basically, and the integral of the main symptoms is reduced by more than or equal to 75 percent;
(2) The effect is shown: no spasmodic cough symptoms appear, the symptoms of even cough and little phlegm appear, the integral of the main symptoms is reduced by more than or equal to 50 percent, but less than 75 percent;
(3) The method is effective: the symptoms of spasmodic cough are reduced, paroxysmal cough still occurs, the integral of main symptoms is reduced by more than or equal to 25 percent, but less than 50 percent;
(4) Invalidation: the clinical symptoms are not obviously improved, and the integral of the main symptoms is reduced by less than 25 percent.
6. Therapeutic results
The treatment results are shown in tables 1 and 2;
table 1 shows the integral comparisons of the primary symptoms x+ -s, score after treatment for examples 1-7 and comparative example 1);
table 2 shows the efficacy comparison after treatment of examples 1-7 and comparative example 1.
TABLE 1
Note that: * p < 0.05 compared with the comparative example
TABLE 2
From tables 1 and 2, the traditional Chinese medicine composition provided by the application has a better treatment effect on spasmodic cough. In clinical use, the traditional Chinese medicine composition provided by the application can obviously shorten the treatment time and has a great clinical use value.
Typical cases
Case 1
The infant is taken by a woman in a year of birth for 4 months, and the symptoms of cough for 2 weeks, cough aggravated and suffocating for 3 days and fever for half a day are taken as the complaints of hospitalization: fever, body temperature fluctuation at 37-37.5 ℃ and cough, paroxysmal spasmodic cough, red eyes after cough, deep aspiration chicken ringing, cough even vomiting, phlegm and saliva and food, heavy day and night, repeated cough at night, difficulty in falling asleep, poor appetite, 3 times daily stool, thin urine and little urine. Checking: red tongue, white coating, purple fingerprint, poor spirit, shortness of breath, weak and positive three-concave symptoms, thick breathing sound of the two lungs, and can smell and moisten the voice, phlegm and a little wheezing. Chest CT: the double lung has coarse texture, uneven local transmittance of lung field, high density of the upper, middle and left lung leaves, and blurred edge. Diagnosis of traditional Chinese medicine: the traditional Chinese medicine granule prepared by the application is administered for treating cough (phlegm obstructing lung and wood fire rising, 3 doses, 0.5 dose per day, oral administration, 3 days of administration, remarkably relieving spasmodic cough, falling asleep at night, no fever and wheezing, 6 days of administration, even cough, little phlegm, basically no cough, no other discomfort, and order to continue taking medicine for consolidating curative effect.
Case 2
Some of the children patients are king, men, 6 months and 17 days, take 'repeated cough for 50 days, aggravate cough and suppress fever for 2 days' as the complaint of taking hospital, the symptoms are as follows: fever, fever peak 38.9 ℃, paroxysmal spasmodic cough, red eyes after cough, obvious cough suppression at night and in the morning, phlegm in the throat, nasal obstruction and nasal discharge, poor dietary sleep, loose stool, 2-4 times daily and little urine. Checking: red tongue, white coating, purple finger print, poor spirit, weak and positive three-concave symptoms, thick breathing sound of the two lungs, and audible and moist rales and wheezy phlegm. Chest DR slice: the two lung textures are much coarser. Diagnosis of traditional Chinese medicine: the traditional Chinese medicine granule prepared by the application is administered for 4 doses, 0.3 dose each time, 2 times daily, orally taken, 3 days of admission, cough and expectoration are relieved, no obvious cough is generated, the spirit is improved, the dietary sleep condition is improved, no fever is generated, the patient takes the medicine on 6 days, the patient has cough occasionally, no cough is generated, no other discomfort is generated, and the patient is instructed to take the medicine continuously from hospital to consolidate the curative effect.
Case 3
Some children are vermilion, women are 5 years old for 5 months, and the patients are admitted by taking cough for more than 10 days as a substitute, the symptoms are as follows: cough, paroxysmal spasmodic cough, red eyes, vomiting of phlegm and saliva and food, can last for about 30 minutes in the morning at 03:00, has no fever, is difficult to fall asleep at night, has normal urine and feces, and has no obvious improvement when being treated by antibiotics, antiallergic drugs and the like. Checking: red tongue, white coating, wiry pulse, poor spirit, engorgement throat, slightly promoted respiration, coarse breathing sound of the two lungs, and audible and moist rales and wheezy phlegm. Diagnosis of traditional Chinese medicine: the traditional Chinese medicine granule prepared by the application is administered for treating cough (phlegm turbidity obstructing lung and wood fire rising), 7 doses of the traditional Chinese medicine granule are taken orally 1 dose per day, the times of taking the cough are reduced on the 4 th day of taking the medicine, the duration is shortened, no vomit basically occurs, the patient can fall asleep stably at night, 7 doses of the traditional Chinese medicine granule are taken, even cough is caused in the night and the morning, no cough is caused, no other discomfort exists, and the patient is ordered to take the medicine continuously outside a hospital to consolidate the curative effect.
Case 4
Some children are grown up, men are aged 3 years for 8 months, and the patients are admitted by taking 'repeated cough half month' as a substitute, the symptoms are as follows: cough, paroxysmal spasmodic cough, red eyes after cough, severe cough, vomiting of phlegm and saliva and food, heavy night attack, difficulty in falling asleep at night, wheeze, no fever, proper diet, normal stool and urine, and no improvement of symptoms after the intravenous anti-infection treatment for 9 days at the outer hospital. Checking: red tongue, white coating, wiry pulse, poor spirit, pharyngeal congestion, slightly promoted respiration, coarse breathing sound of the two lungs, audible and moist heat, wheezy phlegm and a small amount of wheezing. Perfecting blood routine shows: 40.08X109/L of white blood cells, 11.63X109/L of neutrophil count, 26.13X109/L of lymphocyte count and less than 0.499mg/L of C-reactive protein; chest CT: the texture of the two lungs is coarse, the transmittance of the lung fields is uneven, the density of the two lung leaves is increased, and the edges are blurred. Diagnosis of traditional Chinese medicine: the traditional Chinese medicine granule prepared by the application is administered for 10 doses, 1 dose per day, orally taken, taken on 5 days, improved spirit, earlier relief of cough, basically no flushing and vomiting, no wheezing, administration of 10 doses, even cough, phlegm, no other discomfort and blood routine recheck, and the cough is caused by phlegm and the lung is blocked: 9.29×109/L of leucocytes, 2.56×109/L of neutrophil count, 6.29×109/L of lymphocyte count and less than 0.2mg/L of C reactive protein, and the medicine is further taken outside the hospital to consolidate the curative effect.
The foregoing is a preferred embodiment of the present application and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present application and are intended to be comprehended within the scope of the present application.
Claims (9)
1. A traditional Chinese medicine composition for treating spasmodic cough is characterized by being prepared from the following raw materials: 24g of bupleurum, 20g of white peony root, 12g of bitter orange, 6g of liquorice, 20g of white mulberry root-bark, 20g of cortex lycii radicis, 6g of dried ginger, 12g of shizandra berry, 20g of reed rhizome, 12g of inula flower, 20g of bitter apricot seed, 12g of ephedra herb, 12g of cicada slough and 20g of stiff silkworm.
2. A method for preparing a traditional Chinese medicine composition for treating spasmodic cough according to claim 1, comprising the following steps: weighing bupleurum, white peony root, bitter orange, liquorice, white mulberry root-bark, cortex lycii radicis, dried ginger, shizandra berry, reed rhizome, inula flower, bitter apricot seed, ephedra, cicada slough and stiff silkworm according to parts by weight, adding water, decocting for 2 times, combining the two water decoctions, filtering, and collecting filtrate to obtain the traditional Chinese medicine composition.
3. The use of the Chinese medicinal composition for treating spasmodic cough according to claim 1 in preparing a Chinese medicinal preparation, wherein the Chinese medicinal preparation is prepared by adding conventional auxiliary materials into the Chinese medicinal composition as an active ingredient.
4. The use according to claim 3, wherein the Chinese medicinal preparation is a decoction, an oral liquid, a tablet, a capsule or a granule;
the auxiliary materials are selected from pharmaceutically acceptable excipients, diluents, stabilizers, preservatives and flavoring agents.
5. The use according to claim 4, wherein the Chinese medicinal preparation is a decoction, and the specific preparation method comprises the following steps: weighing bupleurum, white peony root, bitter orange, liquorice, white mulberry root-bark, cortex lycii radicis, dried ginger, shizandra berry, reed rhizome, inula flower, bitter apricot seed, ephedra herb, cicada slough and stiff silkworm according to parts by weight, adding water which is 2-3cm higher than decoction pieces, soaking for 20-30 minutes, boiling with strong fire, decocting with slow fire for 20-30 minutes, decocting each dose twice, extruding dregs after the second decoction, and 100-200ml decoction liquid.
6. The use according to claim 4, wherein the Chinese medicinal preparation is an oral liquid, and the specific preparation method comprises the following steps: weighing bupleurum, white peony root, bitter orange, liquorice, white mulberry root-bark, cortex lycii radicis, dried ginger, shizandra berry, reed rhizome, inula flower, bitter apricot seed, ephedra herb, cicada slough and stiff silkworm according to parts by weight, adding water and decocting twice, wherein the water adding amount is 8 times and 6 times of the total weight of the medicinal materials respectively, soaking for 0.5 hour, respectively decocting for 1.5 hour and 1 hour, merging the two water decoctions, filtering, concentrating the filtrate to a liquid medicine with the relative density of 1.05-1.08g/ml at 60 ℃, adding 0.5% of sodium benzoate, cooling, filtering, stirring, encapsulating and sterilizing.
7. The use according to claim 4, wherein the Chinese medicinal preparation is a tablet, and the specific preparation method is as follows: weighing bupleurum, white peony root, bitter orange, liquorice, white mulberry root-bark, cortex lycii radicis, dried ginger, shizandra berry, reed rhizome, inula flower, bitter apricot seed, ephedra herb, cicada slough and stiff silkworm according to parts by weight, adding water and decocting twice, adding water and soaking for 0.5 hour, respectively decocting for 1.5 hours and 1 hour, merging the two water decoctions, filtering, concentrating the filtrate to obtain thick ointment with relative density of 1.35-1.40g/ml at 60 ℃, vacuum drying at the temperature of below 80 ℃, crushing 100 meshes, adding 10% microcrystalline cellulose and 1% starch slurry, granulating, drying at the temperature of 80 ℃, adding 3% magnesium stearate and 3% carboxymethyl starch sodium, uniformly mixing and pressing into tablets, and sugar coating.
8. The use according to claim 4, wherein the Chinese medicinal preparation is a capsule, and the specific preparation method comprises the following steps: weighing bupleurum, white peony root, bitter orange, liquorice, white mulberry root-bark, cortex lycii radicis, dried ginger, shizandra berry, reed rhizome, inula flower, bitter apricot seed, ephedra herb, cicada slough and stiff silkworm according to parts by weight, adding water and decocting twice, adding water and soaking for 0.5 hour, respectively decocting for 1.5 hours and 1 hour, merging the two water decoctions, filtering, concentrating the filtrate to obtain thick ointment with the relative density of 1.35-1.40g/ml at the temperature of 60 ℃, vacuum drying at the temperature of below 80 ℃, crushing 40 meshes, adding 5% microcrystalline cellulose and 5% talcum powder magnesium, uniformly mixing, and filling into capsules.
9. The use according to claim 4, wherein the Chinese medicinal preparation is a granule, and the specific preparation method is as follows: weighing bupleurum, white peony root, bitter orange, liquorice, white mulberry root-bark, cortex lycii radicis, dried ginger, shizandra berry, reed rhizome, inula flower, bitter apricot seed, ephedra herb, cicada slough and stiff silkworm according to parts by weight, adding water and decocting twice, adding water and soaking for 0.5 hour, respectively decocting for 1.5 hours and 1 hour, merging the two water decoctions, filtering, concentrating the filtrate to obtain thick ointment with the relative density of 1.35-1.40g/ml at 60 ℃, adding 20% dextrin, 5% stevioside, granulating with 12 meshes, drying at 80 ℃, finishing granules, and subpackaging.
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| CN102283944A (en) * | 2010-06-17 | 2011-12-21 | 苏州知微堂生物科技有限公司 | Technology for preparing novel integrated dosage form of lung heat expelling powder and production method thereof |
| CN104758906A (en) * | 2015-04-21 | 2015-07-08 | 严芳 | Medicine for treating cough |
| CN105169001A (en) * | 2015-08-27 | 2015-12-23 | 河南中医学院 | Traditional Chinese medicine composition for treating cough variant asthma in children |
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| CN102283944A (en) * | 2010-06-17 | 2011-12-21 | 苏州知微堂生物科技有限公司 | Technology for preparing novel integrated dosage form of lung heat expelling powder and production method thereof |
| CN104758906A (en) * | 2015-04-21 | 2015-07-08 | 严芳 | Medicine for treating cough |
| CN105169001A (en) * | 2015-08-27 | 2015-12-23 | 河南中医学院 | Traditional Chinese medicine composition for treating cough variant asthma in children |
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