CN105169001A - Traditional Chinese medicine composition for treating cough variant asthma in children - Google Patents
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Abstract
The invention relates to a traditional Chinese medicine composition for treating cough variant asthma in children. The traditional Chinese medicine composition is capable of solving the problem of medication use in face of cough variant asthma in children effectively. The technical scheme includes that the traditional Chinese medicine composition is prepared from, by weight, 2-6 parts of herba ephedra, 2-6 parts of bitter apricot seeds, 3-12 parts of radish seeds, 2-10 parts of concretio silicea bambusae, 1-3 parts of agilawood, 2-6 parts of inula flowers, 1-6 parts of bombyx batryticatus, 1-5 parts of nidus vespae, 2-6 parts of giant typhonium rhizomes and 3-10 parts of butterflybush flowers. The traditional Chinese medicine composition is capable of ventilating the stagnated lung qi to relieve a cough, reducing phlegm, depressing qi, dispelling wind and relieving spasm and can improve clinical symptoms of children suffering from the cough variant asthma effectively, thereby being a pharmaceutical innovation for treating the cough variant asthma in children.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of Chinese medicine composition being used for the treatment of cough variant asthma in childhood: prednison comparing.
Background technology
Cough variant asthma (CVA) is a kind of specific type asthma based on chronic cough, clinical main manifestations is zest dry cough, chokes and cough, without expectorant or a small amount of white glutinous expectorant, usual cough is more severe, nocturnal cough is key character, and flu, cold air, dust, oil smoke etc. easily bring out or increase the weight of cough.Some patients is with itching throat, nasal obstruction, watery nasal discharge, and apnea is difficult and stridulate.Cough variant asthma is the commonly encountered diseases of department of pediatrics respiratory system.Children's's irritability is had a surplus, excess of the liver then yang hyperactivity wind-transformation.Exogenous wind endogenous wind is met so that outer interior combined pathogens, and liver lung qi machine is uncomfortable, and malfunction falls in the Xuan Fasu of lung, and very then abnormal rising of lung-QI air flue contraction suddenly causes cough.Fluticasone propionate is the active drug preventing and treating cough variant asthma in childhood: prednison comparing at present, is made up of glucocorticoid and beta 2 receptor agonist, but simple prolonged application hormone easily produces the dependence to hormone, and decrement or drug withdrawal can make cough recur.Therefore, the improvement for the treatment of cough variant asthma in childhood: prednison comparing is the problem needing solution at present badly.
Summary of the invention
For above-mentioned situation, for solving the defect of prior art, the object of the present invention is just to provide a kind of Chinese medicine composition being used for the treatment of cough variant asthma in childhood: prednison comparing, effectively can solve the medication problem of cough variant asthma in childhood: prednison comparing.
The technical scheme that the present invention solves is made up of the material medicine of following weight parts: Herba Ephedrae 2-6 part, Semen Armeniacae Amarum 2-6 part, Semen Raphani 3-12 part, Concretio Silicea Bambusae 2-10 part, Lignum Aquilariae Resinatum 1-3 part, Flos Inulae 2-6 part, Bombyx Batryticatus 1-6 part, Nidus Vespae 1-5 part, Rhizoma Typhonii 2-6 part and Flos Buddlejae 3-10 part, wherein, by Herba Ephedrae, Semen Armeniacae Amarum, Semen Raphani, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum mixes, and adds Herba Ephedrae at every turn, Semen Armeniacae Amarum, Semen Raphani, Concretio Silicea Bambusae, the water heating extraction of Lignum Aquilariae Resinatum 6-10 times weight 2-3 time, each 1-1.5 hour, collecting decoction, filter, obtain the first filtrate, the first filtrate is concentrated into the 1/2-1/3 of original volume, makes A liquid, then by Flos Inulae, Bombyx Batryticatus, Nidus Vespae, Rhizoma Typhonii and Flos Buddlejae mix, and add Flos Inulae, Bombyx Batryticatus, Nidus Vespae, the volumetric concentration of Rhizoma Typhonii and Flos Buddlejae 4-8 times weight is the ethanol of 75%, heating and refluxing extraction 4 hours, filter, decompression filtrate recycling ethanol, obtains the second filtrate, second filtrate is concentrated into the 1/2-1/3 of original volume, make B liquid, by A liquid and B liquid mix homogeneously, being concentrated into relative density at 50 DEG C is the clear paste of 1.10-1.30, add the adjuvant of clear paste weight 20%-60% in clear paste, make Chinese medicine composition clinically according to pharmaceutical preparation conventional method, described adjuvant is one or more the compositions in sucrose, starch, dextrin, Pulvis Talci, magnesium stearate, calcium sulfate.
Chinese medicine composition of the present invention has effect of lung qi dispersing cough-relieving, dissipating phlegm and keeping the adverse QI downwards, dispelling wind spasmolytic, effectively can improve cough variant asthma in childhood: prednison comparing patients clinical symptom, is the innovation on treatment cough variant asthma in childhood: prednison comparing medicine.
Detailed description of the invention
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.
Embodiment 1
The present invention in the specific implementation, can be made up of the material medicine of following weight parts: 3 parts, Herba Ephedrae, 5 parts, Semen Armeniacae Amarum, Semen Raphani 4 parts, Concretio Silicea Bambusae 9 parts, Lignum Aquilariae Resinatum 1 part, Flos Inulae 5 parts, Bombyx Batryticatus 2 parts, 4 parts, Nidus Vespae, Rhizoma Typhonii 3 parts and Flos Buddlejae 9 parts, wherein, by Herba Ephedrae, Semen Armeniacae Amarum, Semen Raphani, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum mixes, and adds Herba Ephedrae at every turn, Semen Armeniacae Amarum, Semen Raphani, Concretio Silicea Bambusae, the water heating extraction of Lignum Aquilariae Resinatum 7 times of weight 2 times, each 1-1.5 hour, collecting decoction, filter, obtain the first filtrate, the first filtrate is concentrated into the 1/2-1/3 of original volume, makes A liquid, then by Flos Inulae, Bombyx Batryticatus, Nidus Vespae, Rhizoma Typhonii and Flos Buddlejae mix, and add Flos Inulae, Bombyx Batryticatus, Nidus Vespae, the volumetric concentration of Rhizoma Typhonii and Flos Buddlejae 5 times of weight is the ethanol of 75%, heating and refluxing extraction 4 hours, filter, decompression filtrate recycling ethanol, obtains the second filtrate, second filtrate is concentrated into the 1/2-1/3 of original volume, make B liquid, by A liquid and B liquid mix homogeneously, being concentrated into relative density at 50 DEG C is the clear paste of 1.10-1.30, add the adjuvant of clear paste weight 30% in clear paste, make Chinese medicine composition clinically according to pharmaceutical preparation conventional method.
Embodiment 2
The present invention in the specific implementation, also can be made up of the material medicine of following weight parts: 4 parts, Herba Ephedrae, 4 parts, Semen Armeniacae Amarum, Semen Raphani 7 parts, Concretio Silicea Bambusae 6 parts, Lignum Aquilariae Resinatum 2 parts, Flos Inulae 4 parts, Bombyx Batryticatus 3 parts, 3 parts, Nidus Vespae, Rhizoma Typhonii 4 parts and Flos Buddlejae 7 parts, wherein, by Herba Ephedrae, Semen Armeniacae Amarum, Semen Raphani, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum mixes, and adds Herba Ephedrae at every turn, Semen Armeniacae Amarum, Semen Raphani, Concretio Silicea Bambusae, the water heating extraction of Lignum Aquilariae Resinatum 8 times of weight 3 times, each 1-1.5 hour, collecting decoction, filter, obtain the first filtrate, the first filtrate is concentrated into the 1/2-1/3 of original volume, makes A liquid, then by Flos Inulae, Bombyx Batryticatus, Nidus Vespae, Rhizoma Typhonii and Flos Buddlejae mix, and add Flos Inulae, Bombyx Batryticatus, Nidus Vespae, the volumetric concentration of Rhizoma Typhonii and Flos Buddlejae 6 times of weight is the ethanol of 75%, heating and refluxing extraction 4 hours, filter, decompression filtrate recycling ethanol, obtains the second filtrate, second filtrate is concentrated into the 1/2-1/3 of original volume, make B liquid, by A liquid and B liquid mix homogeneously, being concentrated into relative density at 50 DEG C is the clear paste of 1.10-1.30, add the adjuvant of clear paste weight 40% in clear paste, make Chinese medicine composition clinically according to pharmaceutical preparation conventional method.
Embodiment 3
The present invention in the specific implementation, also can be made up of the material medicine of following weight parts: 5 parts, Herba Ephedrae, 3 parts, Semen Armeniacae Amarum, Semen Raphani 11 parts, Concretio Silicea Bambusae 3 parts, Lignum Aquilariae Resinatum 3 parts, Flos Inulae 3 parts, Bombyx Batryticatus 5 parts, 2 parts, Nidus Vespae, Rhizoma Typhonii 5 parts and Flos Buddlejae 4 parts, wherein, by Herba Ephedrae, Semen Armeniacae Amarum, Semen Raphani, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum mixes, and adds Herba Ephedrae at every turn, Semen Armeniacae Amarum, Semen Raphani, Concretio Silicea Bambusae, the water heating extraction of Lignum Aquilariae Resinatum 9 times of weight 3 times, each 1-1.5 hour, collecting decoction, filter, obtain the first filtrate, the first filtrate is concentrated into the 1/2-1/3 of original volume, makes A liquid, then by Flos Inulae, Bombyx Batryticatus, Nidus Vespae, Rhizoma Typhonii and Flos Buddlejae mix, and add Flos Inulae, Bombyx Batryticatus, Nidus Vespae, the volumetric concentration of Rhizoma Typhonii and Flos Buddlejae 7 times of weight is the ethanol of 75%, heating and refluxing extraction 4 hours, filter, decompression filtrate recycling ethanol, obtains the second filtrate, second filtrate is concentrated into the 1/2-1/3 of original volume, make B liquid, by A liquid and B liquid mix homogeneously, being concentrated into relative density at 50 DEG C is the clear paste of 1.10-1.30, add the adjuvant of clear paste weight 50% in clear paste, make Chinese medicine composition clinically according to pharmaceutical preparation conventional method.
Prescription of the present invention, wherein,
Herba Ephedrae: pungent, micro-hardship, temperature.Return lung, urinary bladder channel.Function cures mainly: diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.For anemofrigid cold, uncomfortable in chestly to breath with cough, edema due to wind pathogen edema; Bronchial asthma.Herba ephedrae nourishing the lung to arrest cough.Be used for table disease to separate, asthma and cough.
Semen Armeniacae Amarum: bitter, temperature, poisonous.Enter lung, large intestine channel.Function cures mainly: expelling phlegm for arresting cough, relievings asthma, intestine moistening.Control exogenous cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation.
Semen Raphani: nature and flavor: property is put down, acrid in the mouth, sweet.Return lung, spleen, stomach warp.Function cures mainly: help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.Breath with cough for retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots.
Concretio Silicea Bambusae: clear heat and eliminate phlegm, cool heart arresting convulsion.Cure mainly calentura coma delirium, middle wind-phlegm fan in silence, twitch, epilepsy by infantile convulsion.Phlegm-heat cough.
Lignum Aquilariae Resinatum: pungent, bitter, temperature.Return spleen, stomach, kidney, lung meridian.Sending down the abnormal ascending QI warming middle-JIAO, warming the kidney improving inspiration by invigorating kidney-QI.Cure mainly: control QI rising in reverse order and pant, vomiting singultus, abdominal distention, waist knee joint cold caused by deficiency, large intestine constipation due to insufficiency, urine qi stranguria, man's cold sperm.1. " not Lu ": " treat edema due to wind pathogen poison swollen, remove bad odor.”
Flos Inulae: salty, temperature.Enter lung, liver, stomach warp.Expectorant, the therapeutic method to keep the adverse QI flowing downwards, softening the hard mass, row water.Control expectorant knot in the heart, the lower distension of the side of body, cough with asthma, singultus, saliva as shellac varnish, epigastric oppression Ying, eructation unrelieved, extensive abdominal edema.
Bombyx Batryticatus: expelling wind for relieving convulsion, dissipating phlegm and resolving masses.For convulsion with spasms, laryngopharynx swelling and pain, submandibular lymph nodes is scorching, facial paralysis, skin pruritus.
Nidus Vespae: sweet is flat.Return stomach warp.Dispel the wind, counteracting toxic substances, parasite killing, pain relieving, antiallergic.Cure mainly: toothache due to dental caries, sore swollen toxin, acute mastitis, scrofula, skin stubborn dermatitis, fungal infection of hand and foot, allergic constitution.
Rhizoma Typhonii: drying dampness to eliminate phlegm, expellings wind and relieving convulsion, detoxicating and resolving stagnation of pathogens pain relieving.Cure mainly: during wind-phlegm is caused, air port eye is oblique, infantile convulsion epilepsy, tetanus, migraine etc.; Tuberculous lymphadenitis, swollen ulcer drug and venom.
Flos Buddlejae: colored, sweet light, is slightly cold; Leaf, root, micro-hardship, be slightly cold.Clearing away heat-fire, nebula removing, for conjunctival congestion and swelling pain, many tear photophobia, liver heat removing and eyesight improving, the raw nebula film of order, hepatasthenia dim eyesight, blurring of vision, relieving cough and asthma, looks improving and the skin nourishing.Dispel the wind, removing heat from blood, profit liver, improving eyesight.Control conjunctival congestion and swelling pain, many tear photophobia, optic atrohic blindness cataracta, the rotten eye of wind string.
Above-mentioned component science, reasonable compatibility, mutual support, there is effect of lung qi dispersing cough-relieving, dissipating phlegm and keeping the adverse QI downwards, dispelling wind spasmolytic, be effective to treatment, rapid-action, stable curative effect, drug safety, patient compliance is good, has advantages such as improving cough variant asthma in childhood: prednison comparing generation and progress, and obtain sufficient proof through clinical data, pertinent clinical data is as follows:
Clinical data
1 case selection
1.1 choose the court's Pediatric Clinic Children with Tussis Variability Asthma 62 example, adopt random digits table to be divided into two groups.Matched group 31 example; 4 ~ 12 years old age, average (6.1 ± 1.8) year; The course of disease 6 ~ 30 weeks, average (14.8 ± 4.2) week.Treatment group 31 example, 4 ~ 13 years old age, average (6.3 ± 1.9) year; The course of disease 5 ~ 29 weeks, average (15.2 ± 4.6) week.The physical data comparing difference not statistically significants such as two groups of infant sexes, age, courses of disease, have comparability.
1.2 diagnostic criteria CVA diagnose with reference to " children with asthma diagnosis and treatment guide " [pediatrics branch of Chinese Medical Association pneumatology group, " Pediatrics magazine " editorial board, children chronic cough Clinics and Practices guide (trying) [J]. Pediatrics magazine, 2008,46 (2): 105] formulate.1. cough continues > 4 weeks, and be everlasting night and (or) early morning show effect or increase the weight of, and N is based on dry cough; 2. clinically without infection sign, or invalid through long period antibiotic therapy; 3. anti-asthmatic medicament diagnostic treatment is effective; 4. the chronic cough that other reasons causes is got rid of; 5. brinchial provocation test is positive, or End--tidal PCO_2 aberration rate > 20% in the daytime, or Bronchodilation Test is positive; 6. have atopic diseases history in individual or I and II relatives, or allergen detects positive.Wherein 1. ~ be 4. necessary requirement.
1.3 include in and exclusion standard: inclusive criteria: the diagnostic criteria person 1. meeting CVA; 2. 4 ~ 13 years old age; 3. infant and head of a family's informed consent is obtained.Exclusion standard: the 1. chronic cough that causes as Postnasal drip syndromes, chronic pharyngeal infection, gastroesophageal reflux induced cough, eosinophil driven's bronchitis, Cough after Viral Infection etc. of other reasons; 2. congenital respiratory tract, digestive malformation, congenital heart disease and the motionless syndrome of congenital cilium etc.3. foreign-body aspiration is cough caused; 4. rickets is merged, anemia, malnutrition, the chronic diseases such as tuberculosis; 5. to multi-medicament allergy sufferers, or the infant of not received treatment of Chinese herbs.
2 therapeutic schemes:
Matched group: adopt Montelukast sodium chewable tablet (Hangzhou Mo Shadong pharmaceutical Co. Ltd, lot number 2012415), 4 ~ 5 years old person 4mg, 6 ~ 13 years old person 5mg, takes before sleeping every night.
Treatment group: therapy of combining Chinese and Western medicine, Western medicine usage, consumption are the same, and Chinese medicine gives Chinese medicine composition 10g/ time prepared by the inventive method, 2 times/day.
Two groups of courses for the treatment of are 4 weeks.Two groups of treatments period all must not use hormones and other anti-asthmatic.
3 observation index
Cardinal symptom scoring before and after treatment: cough frequency 0 point: without cough; 2 points: cough interval, of short duration outbreak; 4 points: often cough, in paroxysmal; 6 points: frequent paroxysmal cough.Cough degree 0 point: without cough; 2 points: cough once in a while, how in night or outbreak in early morning, do not affect sleep; 4 points: cough is often done, how in night or outbreak in early morning, minimal effect is slept; 6 points: persistence, spastic apasm of coughing, all have outbreak round the clock, impact sleep and work.Cough character 0 point: without cough; 2 points: dry cough; 4 points: choke and cough; 6 points: spasmodic cough.0 point out of breath: nothing; 2 points: even during cough have performance out of breath; 4 points: during cough, often have performance out of breath; 6 points: out of breathly during cough suppress breast, impact is had a rest and life.Itching throat 0 point: nothing; 2 points: even have itching throat; 4 points: time have itching throat to cough; 6 points: continue itching throat for cough.
4 criterions of therapeutical effect
Reference " Chinese medical disease Standardization of diagnosis and curative effect " [State Administration of Traditional Chinese Medicine. Chinese medical disease Standardization of diagnosis and curative effect [S]. Nanjing: publishing house of Nanjing University, 1994:76-77] and " new Chinese medicine guideline of clinical investigations " [Zheng Xiao cornel. new Chinese medicine clinical research guide principle [S]. Beijing: China Medical Science Press, 2002:60] in related standards draft.Cure: clinical symptoms, sign disappear or substantially disappear; Effective: clinical symptoms, sign major part disappears, and primary symptom obviously alleviates; Effective: clinical symptoms, sign make moderate progress, and primary symptom alleviates to some extent; Invalid: clinical symptoms, sign are without improvement or increase the weight of.
5 statistical procedures data softwares adopt SPSS11.0 statistical analysis software, and measurement data adopts
represent, compare between group and adopt t inspection, enumeration data compares employing χ
2inspection, with P < 0.05 for difference has statistical significance.
5.1 clinical efficacy
Experiment terminates rear Clinical efficacy comparison, and treatment group clinical cure 16 example, effective 9 examples, effective 5 examples, invalid 1 example, total effective rate 96.77%, total effective rate compares with matched group, has significant difference.In table 1.
Clinical efficacy comparison (n=31) after table 1 liang group treatment
Compare with matched group, aP < 0.05, bP < 0.01
5.2 clinical symptoms improve situation
After Drug therapy, treatment group, improving in the symptoms such as cough frequency, cough degree, cough character, out of breath, itching throat, compares with after treatment of control group, has extremely significantly meaning (P < 0.01).In table 2.
Table 2 matched group and the cardinal symptom scoring for the treatment of group treatment front and back are compared
With with organize treat before compare, *: P < 0.05, * *: P < 0.01, compares with after treatment of control group, #:P < 0.05, ##:P < 0.01
6 conclusions
To sum up, Chinese medicine composition of the present invention has effect of lung qi dispersing cough-relieving, dissipating phlegm and keeping the adverse QI downwards, dispelling wind spasmolytic, effectively can improve cough variant asthma in childhood: prednison comparing patients clinical symptom, it is the innovation on cough variant asthma in childhood: prednison comparing medicine, effective percentage is up to more than 96%, there is the effect of good treatment cough variant asthma in childhood: prednison comparing, have huge clinical meaning.
Claims (4)
1. be used for the treatment of a Chinese medicine composition for cough variant asthma in childhood: prednison comparing, it is characterized in that, be made up of the material medicine of following weight parts: Herba Ephedrae 2-6 part, Semen Armeniacae Amarum 2-6 part, Semen Raphani 3-12 part, Concretio Silicea Bambusae 2-10 part, Lignum Aquilariae Resinatum 1-3 part, Flos Inulae 2-6 part, Bombyx Batryticatus 1-6 part, Nidus Vespae 1-5 part, Rhizoma Typhonii 2-6 part and Flos Buddlejae 3-10 part, wherein, by Herba Ephedrae, Semen Armeniacae Amarum, Semen Raphani, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum mixes, and adds Herba Ephedrae at every turn, Semen Armeniacae Amarum, Semen Raphani, Concretio Silicea Bambusae, the water heating extraction of Lignum Aquilariae Resinatum 6-10 times weight 2-3 time, each 1-1.5 hour, collecting decoction, filter, obtain the first filtrate, the first filtrate is concentrated into the 1/2-1/3 of original volume, makes A liquid, then by Flos Inulae, Bombyx Batryticatus, Nidus Vespae, Rhizoma Typhonii and Flos Buddlejae mix, and add Flos Inulae, Bombyx Batryticatus, Nidus Vespae, the volumetric concentration of Rhizoma Typhonii and Flos Buddlejae 4-8 times weight is the ethanol of 75%, heating and refluxing extraction 4 hours, filter, decompression filtrate recycling ethanol, obtains the second filtrate, second filtrate is concentrated into the 1/2-1/3 of original volume, make B liquid, by A liquid and B liquid mix homogeneously, being concentrated into relative density at 50 DEG C is the clear paste of 1.10-1.30, add the adjuvant of clear paste weight 20%-60% in clear paste, make Chinese medicine composition clinically according to pharmaceutical preparation conventional method, described adjuvant is one or more the compositions in sucrose, starch, dextrin, Pulvis Talci, magnesium stearate, calcium sulfate.
2. the Chinese medicine composition being used for the treatment of cough variant asthma in childhood: prednison comparing according to claim 1, is characterized in that, is made up of the material medicine of following weight parts: 3 parts, Herba Ephedrae, 5 parts, Semen Armeniacae Amarum, Semen Raphani 4 parts, Concretio Silicea Bambusae 9 parts, Lignum Aquilariae Resinatum 1 part, Flos Inulae 5 parts, Bombyx Batryticatus 2 parts, 4 parts, Nidus Vespae, Rhizoma Typhonii 3 parts and Flos Buddlejae 9 parts, wherein, by Herba Ephedrae, Semen Armeniacae Amarum, Semen Raphani, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum mixes, and adds Herba Ephedrae at every turn, Semen Armeniacae Amarum, Semen Raphani, Concretio Silicea Bambusae, the water heating extraction of Lignum Aquilariae Resinatum 7 times of weight 2 times, each 1-1.5 hour, collecting decoction, filter, obtain the first filtrate, the first filtrate is concentrated into the 1/2-1/3 of original volume, makes A liquid, then by Flos Inulae, Bombyx Batryticatus, Nidus Vespae, Rhizoma Typhonii and Flos Buddlejae mix, and add Flos Inulae, Bombyx Batryticatus, Nidus Vespae, the volumetric concentration of Rhizoma Typhonii and Flos Buddlejae 5 times of weight is the ethanol of 75%, heating and refluxing extraction 4 hours, filter, decompression filtrate recycling ethanol, obtains the second filtrate, second filtrate is concentrated into the 1/2-1/3 of original volume, make B liquid, by A liquid and B liquid mix homogeneously, being concentrated into relative density at 50 DEG C is the clear paste of 1.10-1.30, add the adjuvant of clear paste weight 30% in clear paste, make Chinese medicine composition clinically according to pharmaceutical preparation conventional method.
3. the Chinese medicine composition being used for the treatment of cough variant asthma in childhood: prednison comparing according to claim 1, is characterized in that, is made up of the material medicine of following weight parts: 4 parts, Herba Ephedrae, 4 parts, Semen Armeniacae Amarum, Semen Raphani 7 parts, Concretio Silicea Bambusae 6 parts, Lignum Aquilariae Resinatum 2 parts, Flos Inulae 4 parts, Bombyx Batryticatus 3 parts, 3 parts, Nidus Vespae, Rhizoma Typhonii 4 parts and Flos Buddlejae 7 parts, wherein, by Herba Ephedrae, Semen Armeniacae Amarum, Semen Raphani, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum mixes, and adds Herba Ephedrae at every turn, Semen Armeniacae Amarum, Semen Raphani, Concretio Silicea Bambusae, the water heating extraction of Lignum Aquilariae Resinatum 8 times of weight 3 times, each 1-1.5 hour, collecting decoction, filter, obtain the first filtrate, the first filtrate is concentrated into the 1/2-1/3 of original volume, makes A liquid, then by Flos Inulae, Bombyx Batryticatus, Nidus Vespae, Rhizoma Typhonii and Flos Buddlejae mix, and add Flos Inulae, Bombyx Batryticatus, Nidus Vespae, the volumetric concentration of Rhizoma Typhonii and Flos Buddlejae 6 times of weight is the ethanol of 75%, heating and refluxing extraction 4 hours, filter, decompression filtrate recycling ethanol, obtains the second filtrate, second filtrate is concentrated into the 1/2-1/3 of original volume, make B liquid, by A liquid and B liquid mix homogeneously, being concentrated into relative density at 50 DEG C is the clear paste of 1.10-1.30, add the adjuvant of clear paste weight 40% in clear paste, make Chinese medicine composition clinically according to pharmaceutical preparation conventional method.
4. the Chinese medicine composition being used for the treatment of cough variant asthma in childhood: prednison comparing according to claim 1, is characterized in that, is made up of the material medicine of following weight parts: 5 parts, Herba Ephedrae, 3 parts, Semen Armeniacae Amarum, Semen Raphani 11 parts, Concretio Silicea Bambusae 3 parts, Lignum Aquilariae Resinatum 3 parts, Flos Inulae 3 parts, Bombyx Batryticatus 5 parts, 2 parts, Nidus Vespae, Rhizoma Typhonii 5 parts and Flos Buddlejae 4 parts, wherein, by Herba Ephedrae, Semen Armeniacae Amarum, Semen Raphani, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum mixes, and adds Herba Ephedrae at every turn, Semen Armeniacae Amarum, Semen Raphani, Concretio Silicea Bambusae, the water heating extraction of Lignum Aquilariae Resinatum 9 times of weight 3 times, each 1-1.5 hour, collecting decoction, filter, obtain the first filtrate, the first filtrate is concentrated into the 1/2-1/3 of original volume, makes A liquid, then by Flos Inulae, Bombyx Batryticatus, Nidus Vespae, Rhizoma Typhonii and Flos Buddlejae mix, and add Flos Inulae, Bombyx Batryticatus, Nidus Vespae, the volumetric concentration of Rhizoma Typhonii and Flos Buddlejae 7 times of weight is the ethanol of 75%, heating and refluxing extraction 4 hours, filter, decompression filtrate recycling ethanol, obtains the second filtrate, second filtrate is concentrated into the 1/2-1/3 of original volume, make B liquid, by A liquid and B liquid mix homogeneously, being concentrated into relative density at 50 DEG C is the clear paste of 1.10-1.30, add the adjuvant of clear paste weight 50% in clear paste, make Chinese medicine composition clinically according to pharmaceutical preparation conventional method.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105663714A (en) * | 2016-02-03 | 2016-06-15 | 魏淑英 | Traditional Chinese medicine composition for treating lung deficiency and liver sthenia type children cough variant asthma |
| CN115089689A (en) * | 2022-07-22 | 2022-09-23 | 河南省儿童医院郑州儿童医院 | Traditional Chinese medicine composition for treating spasmodic cough and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103990025A (en) * | 2014-06-17 | 2014-08-20 | 刘青振 | Traditional Chinese medicine for treating children cough variant asthma and preparation method of traditional Chinese medicine |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103990025A (en) * | 2014-06-17 | 2014-08-20 | 刘青振 | Traditional Chinese medicine for treating children cough variant asthma and preparation method of traditional Chinese medicine |
Non-Patent Citations (1)
| Title |
|---|
| 张善彬: "止咳合剂治疗儿童咳嗽变异性哮喘48例疗效观察", 《河北中医》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105663714A (en) * | 2016-02-03 | 2016-06-15 | 魏淑英 | Traditional Chinese medicine composition for treating lung deficiency and liver sthenia type children cough variant asthma |
| CN115089689A (en) * | 2022-07-22 | 2022-09-23 | 河南省儿童医院郑州儿童医院 | Traditional Chinese medicine composition for treating spasmodic cough and preparation method and application thereof |
| CN115089689B (en) * | 2022-07-22 | 2023-09-22 | 河南省儿童医院郑州儿童医院 | Traditional Chinese medicine composition for treating spasmodic cough as well as preparation method and application thereof |
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| Publication number | Publication date |
|---|---|
| CN105169001B (en) | 2018-08-07 |
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