CN105169001B - A kind of Chinese medicine composition for treating cough variant asthma in childhood: prednison comparing - Google Patents
A kind of Chinese medicine composition for treating cough variant asthma in childhood: prednison comparing Download PDFInfo
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Abstract
The present invention relates to the Chinese medicine compositions for treating cough variant asthma in childhood: prednison comparing, can effectively solve the problems, such as the medication of cough variant asthma in childhood: prednison comparing, and the technical solution solved is made of the material medicine of following parts by weight meter：3 10 parts of 26 parts of Chinese ephedra, 26 parts of almond, 3 12 parts of radish seed, 2 10 parts of tabasheer, 13 parts of agalloch eaglewood, 26 parts of inular flower, 16 parts of stiff silkworm, 15 parts of honeycomb, 26 parts of rhizoma typhonii and butterflybush flower, the Chinese medicine composition of the present invention has the effect of ventilating the lung and relieving cough, dissipating phlegm and keeping the adverse QI downwards, dispelling wind spasmolysis, it can be effectively improved cough variant asthma in childhood: prednison comparing patients clinical symptom, be the innovation treated on cough variant asthma in childhood: prednison comparing drug.
Description
Technical field
The present invention relates to field of medicaments, especially a kind of Chinese medicine compositions for treating cough variant asthma in childhood: prednison comparing.
Background technology
Cough variant asthma (CVA) is a kind of specific type asthma based on chronic cough, and clinical manifestation is
Irritation dry cough, cough of choking, without phlegm or a small amount of phlegm glutinous in vain, usually cough is more severe, and nocturnal cough is important feature, flu, cold
The easy induction such as air, dust, oil smoke or exacerbation cough.Some patientss itch with pharynx, have a stuffy nose, runny nose, and apnea is difficult and asthma
Ring.Cough variant asthma is the common disease of paediatrics respiratory system.Children's irritability is had a surplus, excess of the liver then positive highization wind.In exogenous wind
Wind facies is poly- so that outer interior conjunctions is evil, and liver lung qi machine is uncomfortable, and a surname of lung sends out drop malfunction respectful, very then Lung Qi upward reversal air flue contraction urgency and cause
Cough.Fluticasone propionate is the active drug of current prevention cough variant asthma in childhood: prednison comparing, by glucocorticoid and β 2 receptor agonist
Composition, but simple prolonged application hormone is also easy to produce the dependence to hormone, and decrement or drug withdrawal can be such that cough recurs.Therefore, it controls
The problem of improvement for treating cough variant asthma in childhood: prednison comparing is current urgent need to resolve.
Invention content
For the above situation, to solve the defect of the prior art, the purpose of the present invention be just to provide it is a kind of be used to treat it is small
The Chinese medicine composition of youngster's cough variant asthma can effectively solve the problems, such as the medication of cough variant asthma in childhood: prednison comparing.
The technical solution that the present invention solves is made of the material medicine of following parts by weight meter：2-6 parts of Chinese ephedra, almond
2-6 parts, it is 3-12 parts of radish seed, 2-10 parts of tabasheer, 1-3 parts of agalloch eaglewood, 2-6 parts of inular flower, 1-6 parts of stiff silkworm, 1-5 parts of honeycomb, white
3-10 parts of 2-6 parts of monkshood and butterflybush flower, wherein Chinese ephedra, almond, radish seed, tabasheer, agalloch eaglewood are mixed, added every time
Water heating extracting 2-3 times of Chinese ephedra, almond, radish seed, 6-10 times of tabasheer, agalloch eaglewood weight, it is 1-1.5 hours each, merge and decocts
Liquid, filtering, obtains the first filtrate, and the first filtrate is concentrated into the 1/2-1/3 of original volume, is made A liquid, then by inular flower, stiff silkworm, bee
Room, rhizoma typhonii and butterflybush flower mix, add inular flower, stiff silkworm, 4-8 times of honeycomb, rhizoma typhonii and butterflybush flower weight volume
A concentration of 75% ethyl alcohol, heating and refluxing extraction 4 hours, filtering, decompression filtrate recycling ethanol obtain the second filtrate, the second filtrate
It is concentrated into the 1/2-1/3 of original volume, B liquid is made, A liquid and B liquid are uniformly mixed, it is 1.10- to be concentrated into relative density at 50 DEG C
The auxiliary material of clear cream weight 20%-60% is added in clear cream, is made clinically according to pharmaceutical preparation conventional method for 1.30 clear cream
Chinese medicine composition；The auxiliary material be sucrose, starch, dextrin, talcum powder, magnesium stearate, one or both of calcium sulfate with
On composition.
The Chinese medicine composition of the present invention has the effect of ventilating the lung and relieving cough, dissipating phlegm and keeping the adverse QI downwards, dispelling wind spasmolysis, can be effectively improved children
Cough variant asthma patients clinical symptom is the innovation treated on cough variant asthma in childhood: prednison comparing drug.
Specific implementation mode
The specific implementation mode of the present invention is described in further detail with reference to embodiments.
Embodiment 1
The present invention in the specific implementation, can be made of the material medicine of following parts by weight meter：3 parts of Chinese ephedra, 5 parts of almond,
9 parts of 4 parts of radish seed, 9 parts of tabasheer, 1 part of agalloch eaglewood, 5 parts of inular flower, 2 parts of stiff silkworm, 4 parts of honeycomb, 3 parts of rhizoma typhonii and butterflybush flower,
In, Chinese ephedra, almond, radish seed, tabasheer, agalloch eaglewood are mixed, adds Chinese ephedra every time, almond, radish seed, tabasheer, sink
The water heating extracting of fragrant 7 times of weight 2 times, 1-1.5 hours each, collecting decoction, filtering obtain the first filtrate, the concentration of the first filtrate
To the 1/2-1/3 of original volume, A liquid is made, then inular flower, stiff silkworm, honeycomb, rhizoma typhonii and butterflybush flower are mixed, puts english
Multiple flower, stiff silkworm, honeycomb, 5 times of weight of rhizoma typhonii and butterflybush flower volumetric concentration be 75% ethyl alcohol, heating and refluxing extraction 4 hours,
Filtering, decompression filtrate recycling ethanol obtain the second filtrate, and the second filtrate is concentrated into the 1/2-1/3 of original volume, and B liquid is made, by A liquid
It is uniformly mixed with B liquid, is concentrated into the clear cream that relative density at 50 DEG C is 1.10-1.30, clear cream weight 30% is added in clear cream
Chinese medicine composition clinically is made according to pharmaceutical preparation conventional method in auxiliary material.
Embodiment 2
The present invention in the specific implementation, can also be made of the material medicine of following parts by weight meter：4 parts of Chinese ephedra, almond 4
Part, 7 parts of radish seed, 6 parts of tabasheer, 2 parts of agalloch eaglewood, 4 parts of inular flower, 3 parts of stiff silkworm, 3 parts of honeycomb, 4 parts of rhizoma typhonii and butterflybush flower 7
Part, wherein Chinese ephedra, almond, radish seed, tabasheer, agalloch eaglewood are mixed, add Chinese ephedra, almond, radish seed, India every time
Yellow, 8 times of weight of agalloch eaglewood water heating extracting 3 times, 1-1.5 hours each, collecting decoction, filtering obtain the first filtrate, the first filtrate
It is concentrated into the 1/2-1/3 of original volume, A liquid is made, then inular flower, stiff silkworm, honeycomb, rhizoma typhonii and butterflybush flower are mixed,
Add inular flower, stiff silkworm, honeycomb, 6 times of weight of rhizoma typhonii and butterflybush flower volumetric concentration be 75% ethyl alcohol, heating and refluxing extraction 4
Hour, filtering, decompression filtrate recycling ethanol obtains the second filtrate, and the second filtrate is concentrated into the 1/2-1/3 of original volume, and B liquid is made,
A liquid and B liquid are uniformly mixed, the clear cream that relative density at 50 DEG C is 1.10-1.30 is concentrated into, clear cream weight is added in clear cream
Chinese medicine composition clinically is made according to pharmaceutical preparation conventional method in 40% auxiliary material.
Embodiment 3
The present invention in the specific implementation, can also be made of the material medicine of following parts by weight meter：5 parts of Chinese ephedra, almond 3
Part, 11 parts of radish seed, 3 parts of tabasheer, 3 parts of agalloch eaglewood, 3 parts of inular flower, 5 parts of stiff silkworm, 2 parts of honeycomb, 5 parts of rhizoma typhonii and butterflybush flower 4
Part, wherein Chinese ephedra, almond, radish seed, tabasheer, agalloch eaglewood are mixed, add Chinese ephedra, almond, radish seed, India every time
Yellow, 9 times of weight of agalloch eaglewood water heating extracting 3 times, 1-1.5 hours each, collecting decoction, filtering obtain the first filtrate, the first filtrate
It is concentrated into the 1/2-1/3 of original volume, A liquid is made, then inular flower, stiff silkworm, honeycomb, rhizoma typhonii and butterflybush flower are mixed,
Add inular flower, stiff silkworm, honeycomb, 7 times of weight of rhizoma typhonii and butterflybush flower volumetric concentration be 75% ethyl alcohol, heating and refluxing extraction 4
Hour, filtering, decompression filtrate recycling ethanol obtains the second filtrate, and the second filtrate is concentrated into the 1/2-1/3 of original volume, and B liquid is made,
A liquid and B liquid are uniformly mixed, the clear cream that relative density at 50 DEG C is 1.10-1.30 is concentrated into, clear cream weight is added in clear cream
Chinese medicine composition clinically is made according to pharmaceutical preparation conventional method in 50% auxiliary material.
Prescription of the present invention, wherein
Chinese ephedra：Pungent, slight bitter, temperature.Return lung, bladder warp.Major function：Sweating cold dispelling, freeings lung and relieving asthma, inducing diuresis for removing edema.For
Anemofrigid cold, uncomfortable in chest to breath with cough, geomantic omen edema；Bronchial asthma.Herba ephedrae moistens the lung and relieve the cough.It is chiefly used in table disease to have solved, asthma and cough.
Almond：Hardship, temperature are toxic.Enter lung, large intestine channel.Major function：Expelling phlegm and arresting coughing is relievingd asthma, ease constipation.Exogenous cough is controlled, is breathed heavily
It is full, larynx numbness, dry constipation of intestines.
Radish seed：Nature and flavor：It is mild-natured, it is acrid flavour, sweet.Return lung, spleen, stomach.Major function：Help digestion and eliminate flatulence, lowering the adverse-rising QI to resolve phlegm.For
Retention of food and drink, abdominal distention, constipation, stagnant rush down dysentery, phlegm heap soil or fertilizer over and around the roots are breathed with cough.
Tabasheer：Heat phlegm, cool heart arresting convulsion.Pyreticosis coma delirium is cured mainly, stroke and phlegm confusing heart in silence, twitch by child convulsion,
Epilepsy.Phlegm-heat cough.
Agalloch eaglewood：It is pungent, bitter, temperature.Returns spleen, stomach, kidney, lung channel.Sending down abnormally ascending middle benefit gas, warm kidney receive gas.It cures mainly：It controls the circulation of vital energy in the wrong direction to pant, vomit
Hiccup, abdominal distention, waist and knee void is cold, and large intestine void is secret, the leaching of urine gas, man's cold sperm.①《It does not record》：" it is swollen to treat geomantic omen poison, goes to dislike
Gas.”
Inular flower：It is salty, temperature.Enter lung, liver, stomach.Dissolving phlegm, lower gas, softening hard masses, row water.Phlegm knot in the heart is controlled, lower turgor, cough are coerced
Asthma, hiccup, saliva such as shellac varnish, epigastric fullness Ying, eructation unrelieved, extensive abdominal edema.
Stiff silkworm：Dispelling wind and relieving convulsion, reducing phlegm and resolving masses.For convulsion, abscess of throat, submandibular lymph nodes is scorching, facioplegia,
Pruitus.
Honeycomb：Sweet and neutral.Return stomach.Poison, desinsection, analgesic, antiallergy are attacked in wind-dispelling.It cures mainly：Dental caries and toothache, sore swollen toxin,
Acute mastitis, scrofula, skin stubborn dermatitis, the fungal infection of the hand, allergic constitution.
Rhizoma typhonii：It is eliminating dampness and eliminating phlegm, expelling wind and relieving convulsion, detoxicating and resolving a mass analgesic.It cures mainly：Tiltedly, infantile convulsion is insane for middle air port eye caused by wind phlegm
Epilepsy, lockjaw, migraine etc.；Tuberculous lymphadenitis, swollen ulcer drug and venomous snake bite.
Butterflybush flower：It is colored, sweet light, it is slightly cold；Leaf, root, slight bitter, are slightly cold.Clearing heat-fire moves back screen, is shy for red eye, swell pain, more tears
It is bright, clear liver and improve vision, raw screen film of mesh, hepatasthenia dim eyesight, blurring of vision, relieving cough and asthma, beautifying face and moistering lotion.Wind-dispelling, cool blood moisten liver, improving eyesight.
Control red eye, swell pain, more tear photophobia, glaucoma ocular, the rotten eye of wind string.
Above-mentioned component science, reasonable compatibility support there is the effect of ventilating the lung and relieving cough, dissipating phlegm and keeping the adverse QI downwards, dispelling wind spasmolysis mutually,
Rapid-action effective for treatment, curative effect is stablized, and drug safety, patient compliance is good, and having improves cough variant asthma in childhood: prednison comparing
The advantages that occurring and being in progress, and obtained fully proving through clinical data, related clinical data is as follows：
Clinical data
1 case selection
1.1 choose the court's Pediatric Clinic Children with Tussis Variability Asthma 62, are divided into two groups using random digits table.It is right
According to group 31；4~12 years old age, average (6.1 ± 1.8) year；The course of disease 6~30 weeks, average (14.8 ± 4.2) week.Treatment group 31
Example, 4~13 years old age, average (6.3 ± 1.9) year；The course of disease 5~29 weeks, average (15.2 ± 4.6) week.Two groups of infant genders, years
The general information comparing difference such as age, course of disease is not statistically significant, is comparable.
1.2 diagnostic criteria CVA diagnose reference《Children with asthma diagnosis and treatment guide》[Chinese Medical Association's paediatrics
Branch's pneumatology group,《Pediatrics magazine》Editorial board, in children chronic cough Clinics and Practices guide (tentative) [J]
Magnificent paediatrics magazine, 2008,46 (2):105] it formulates.1. cough continues 4 weeks ＞, often in night and (or) early morning breaking-out or exacerbation, N
Based on dry cough；2. or invalid through long period antibiosis extract for treating clinically without infection sign；It is controlled 3. anti-asthmatic medicament is diagnostic
It treats effective；4. excluding chronic cough caused by other reasons；5. bronchial provocation test is positive or End--tidal PCO_2 makes a variation in the daytime
Rate ＞ 20%, or Bronchodilation Test are positive；6. having atopic diseases history or allergen inspection in personal or I and II relatives
It surveys positive.Wherein 1.~4. it is necessary requirement.
1.3 are included in and exclusion criteria:Inclusion criteria:1. meeting the diagnostic criteria person of CVA；2. 4~13 years old age；3. obtaining
Infant and parent's informed consent.Exclusion criteria:1. other reasons such as Postnasal drip syndromes, chronic pharyngeal infection, stomach oesophagus is anti-
Chronic cough caused by fluidity cough, eosinophil driven's bronchitis, Cough after Viral Infection etc.；2. congenital respiratory tract disappears
Change road deformity, congenital heart disease and the motionless syndrome of congenital cilium etc..3. foreign-body aspiration is cough caused；4. merge rickets,
Anaemia, malnutritive, the chronic diseases such as tuberculosis；5. to a variety of drug allergy persons, or the not infant of received treatment of Chinese herbs.
2 therapeutic schemes：
Control group：Using Montelukast sodium chewable tablet (Hangzhou Mo Shadong pharmaceutical Co. Ltds, lot number 2012415), 4~5
Year person 4mg, 6~13 years old person 5mg take before sleeping every night.
Treatment group：Therapy of combing traditional Chinese and Western medicine, Western medicine usage, dosage are the same, and Chinese medicine gives the Chinese medicine of the method for the present invention preparation
Composition 10g/ times, 2 times/day.
Two groups of courses for the treatment of are 4 weeks.Steroids and other antiasthmatics must not be used during two groups of treatments.
3 observation index
Pretherapy and post-treatment cardinal symptom scoring:Cough frequency 0 divides:Without cough；2 points:Cough interval, of short duration breaking-out；4 points:Through
Often cough is in paroxysmal；6 points:Frequent paroxysmal cough.Cough degree 0 is divided:Without cough；2 points:Cough once in a while, mostly at night or
Early morning breaks out, and does not influence to sleep；4 points:Cough is often made, and mostly breaks out at night or early morning, minimal effect sleep；6 points:Duration,
Spastic paroxysmal cough, there is breaking-out round the clock, influences to sleep and work.Cough property 0 is divided:Without cough；2 points:Dry cough；4 points:It chokes cough；6
Point:Spasmodic cough.0 point out of breath:Nothing；2 points:Occasionally there is performance out of breath when cough；4 points:Often there is performance out of breath when cough；
6 points:It is out of breath when cough to suppress chest, it influences to rest and live.Pharynx is itched 0 point:Nothing；2 points:Occasionally there is pharynx to itch；4 points:When there is pharynx to itch cough；6
Point:Lasting pharynx, which is itched, to be intended to cough.
4 criterions of therapeutical effect
Reference《Chinese medical disease Standardization of diagnosis and curative effect》[State Administration of Traditional Chinese Medicine Chinese medical diseases Standardization of diagnosis and curative effect [S]
Nanjing:Publishing house of Nanjing University, 1994:76-77] and《New Chinese medicine guideline of clinical investigations》[Zheng Xiao cornel new Chinese medicines face
The Beijing bed Guide to research principle [S]:China Medical Science Press, 2002:60] related standard is drafted in.It cures:Clinical condition
Shape, sign disappear or mostly disappear；It is effective:Clinical symptoms, sign largely disappear, and primary symptom is substantially reduced；Effectively:Clinical condition
Shape, sign make moderate progress, and primary symptom is mitigated；In vain:Clinical symptoms, sign without improvement or aggravate.
5 statistical procedures data softwares use SPSS11.0 statistical analysis softwares, measurement data to useIt indicates, between group
Compare and examined using t, enumeration data compares using χ2It examines, is that difference is statistically significant with P ＜ 0.05.
5.1 clinical efficacy
Clinical efficacy comparison after experiment, it is treatment group's clinical cure 16,9 effective, 5 effective, invalid 1, always
Effective percentage 96.77%, total effective rate compared with the control group, have significant difference.It is shown in Table 1.
Clinical efficacy comparison (n=31) after 1 two groups of treatments of table
Compared with the control group, a P ＜ 0.05, b P ＜ 0.01
5.2 clinical symptoms improve situation
After drug therapy, treatment group improve cough frequency, cough degree, cough property, out of breath, pharynx such as are itched at the symptoms side
There is extremely notable meaning (P ＜ 0.01) in face compared with after control group treatment.It is shown in Table 2.
The pretherapy and post-treatment cardinal symptom scoring of 2 control group of table and treatment group is compared
Compared with before same group for the treatment of, *:P ＜ 0.05, * *:P ＜ 0.01, compared with after control group treatment, #:P ＜
0.05, ##:P ＜ 0.01
6 conclusions
To sum up, Chinese medicine composition of the present invention has the effect of ventilating the lung and relieving cough, dissipating phlegm and keeping the adverse QI downwards, dispelling wind spasmolysis, can be effectively improved
Cough variant asthma in childhood: prednison comparing patients clinical symptom, is the innovation on cough variant asthma in childhood: prednison comparing drug, and high efficiency reaches
96% or more, have the effect of good treatment cough variant asthma in childhood: prednison comparing, there is huge clinical meaning.
Claims (4)
1. a kind of Chinese medicine composition for treating cough variant asthma in childhood: prednison comparing, which is characterized in that by following parts by weight meter
Material medicine be made：2-6 parts of Chinese ephedra, 2-6 parts of almond, 3-12 parts of radish seed, 2-10 parts of tabasheer, 1-3 parts of agalloch eaglewood, inular flower
3-10 parts of 2-6 parts, 1-6 parts of stiff silkworm, 1-5 parts of honeycomb, 2-6 parts of rhizoma typhonii and butterflybush flower, wherein by Chinese ephedra, almond, radish seed,
Tabasheer, agalloch eaglewood mix, and every time plus the water heating of Chinese ephedra, almond, radish seed, 6-10 times of tabasheer, agalloch eaglewood weight carries
It taking 2-3 times, 1-1.5 hours each, collecting decoction, filters, obtain the first filtrate, the first filtrate is concentrated into the 1/2-1/3 of original volume,
A liquid is made, then inular flower, stiff silkworm, honeycomb, rhizoma typhonii and butterflybush flower are mixed, adds inular flower, stiff silkworm, honeycomb, white attached
The ethyl alcohol that the volumetric concentration of son and 4-8 times of weight of butterflybush flower is 75%, heating and refluxing extraction 4 hours, filtering, filtrate decompression recycling
Ethyl alcohol obtains the second filtrate, and the second filtrate is concentrated into the 1/2-1/3 of original volume, and B liquid is made, and A liquid and B liquid are uniformly mixed, concentration
Relative density is the clear cream of 1.10-1.30 to 50 DEG C, the auxiliary material of clear cream weight 20%-60% is added in clear cream, according to drug system
Chinese medicine composition clinically is made in agent conventional method；The auxiliary material be sucrose, starch, dextrin, talcum powder, magnesium stearate,
The composition of one or more of calcium sulfate.
2. the Chinese medicine composition according to claim 1 for treating cough variant asthma in childhood: prednison comparing, which is characterized in that by
The material medicine of following parts by weight meter is made：3 parts of Chinese ephedra, 5 parts of almond, 4 parts of radish seed, 9 parts of tabasheer, 1 part of agalloch eaglewood, inula
Spend 5 parts, 2 parts of stiff silkworm, 4 parts of honeycomb, 9 parts of 3 parts of rhizoma typhonii and butterflybush flower, wherein by Chinese ephedra, almond, radish seed, tabasheer, heavy
Perfume (or spice) mixes, every time plus the water heating extracting 2 times of Chinese ephedra, almond, radish seed, 7 times of tabasheer, agalloch eaglewood weight, each 1-
1.5 hours, collecting decoction, filtering obtained the first filtrate, and the first filtrate is concentrated into the 1/2-1/3 of original volume, A liquid was made, then will rotation
Multiple flower, stiff silkworm, honeycomb, rhizoma typhonii and butterflybush flower mix, and add 5 times of inular flower, stiff silkworm, honeycomb, rhizoma typhonii and butterflybush flower
The ethyl alcohol that the volumetric concentration of weight is 75%, heating and refluxing extraction 4 hours, filtering, decompression filtrate recycling ethanol obtain the second filtrate,
Second filtrate is concentrated into the 1/2-1/3 of original volume, and B liquid is made, and A liquid and B liquid are uniformly mixed, and is concentrated into relative density at 50 DEG C
For the clear cream of 1.10-1.30, the auxiliary material of clear cream weight 30% is added in clear cream, is made clinically according to pharmaceutical preparation conventional method
Chinese medicine composition.
3. the Chinese medicine composition according to claim 1 for treating cough variant asthma in childhood: prednison comparing, which is characterized in that by
The material medicine of following parts by weight meter is made：4 parts of Chinese ephedra, 4 parts of almond, 7 parts of radish seed, 6 parts of tabasheer, 2 parts of agalloch eaglewood, inula
Spend 4 parts, 3 parts of stiff silkworm, 3 parts of honeycomb, 7 parts of 4 parts of rhizoma typhonii and butterflybush flower, wherein by Chinese ephedra, almond, radish seed, tabasheer, heavy
Perfume (or spice) mixes, every time plus the water heating extracting 3 times of Chinese ephedra, almond, radish seed, 8 times of tabasheer, agalloch eaglewood weight, each 1-
1.5 hours, collecting decoction, filtering obtained the first filtrate, and the first filtrate is concentrated into the 1/2-1/3 of original volume, A liquid was made, then will rotation
Multiple flower, stiff silkworm, honeycomb, rhizoma typhonii and butterflybush flower mix, and add 6 times of inular flower, stiff silkworm, honeycomb, rhizoma typhonii and butterflybush flower
The ethyl alcohol that the volumetric concentration of weight is 75%, heating and refluxing extraction 4 hours, filtering, decompression filtrate recycling ethanol obtain the second filtrate,
Second filtrate is concentrated into the 1/2-1/3 of original volume, and B liquid is made, and A liquid and B liquid are uniformly mixed, and is concentrated into relative density at 50 DEG C
For the clear cream of 1.10-1.30, the auxiliary material of clear cream weight 40% is added in clear cream, is made clinically according to pharmaceutical preparation conventional method
Chinese medicine composition.
4. the Chinese medicine composition according to claim 1 for treating cough variant asthma in childhood: prednison comparing, which is characterized in that by
The material medicine of following parts by weight meter is made：5 parts of Chinese ephedra, 3 parts of almond, 11 parts of radish seed, 3 parts of tabasheer, 3 parts of agalloch eaglewood, rotation
Spend again 3 parts, 5 parts of stiff silkworm, 2 parts of honeycomb, 4 parts of 5 parts of rhizoma typhonii and butterflybush flower, wherein by Chinese ephedra, almond, radish seed, tabasheer,
Agalloch eaglewood mixes, every time plus the water heating extracting 3 times of Chinese ephedra, almond, radish seed, 9 times of tabasheer, agalloch eaglewood weight, every time
1-1.5 hours, collecting decoction, filtering obtained the first filtrate, and the first filtrate is concentrated into the 1/2-1/3 of original volume, A liquid was made, then will
Inular flower, stiff silkworm, honeycomb, rhizoma typhonii and butterflybush flower mix, and add inular flower, stiff silkworm, honeycomb, rhizoma typhonii and butterflybush flower 7
The ethyl alcohol that the volumetric concentration of times weight is 75%, heating and refluxing extraction 4 hours, filtering, decompression filtrate recycling ethanol obtain the second filter
Liquid, the second filtrate are concentrated into the 1/2-1/3 of original volume, and B liquid is made, and A liquid and B liquid are uniformly mixed, and are concentrated at 50 DEG C opposite
Density is the clear cream of 1.10-1.30, and the auxiliary material of clear cream weight 50% is added in clear cream, is made and faces according to pharmaceutical preparation conventional method
Chinese medicine composition on bed.
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| 止咳合剂治疗儿童咳嗽变异性哮喘48例疗效观察;张善彬;《河北中医》;20090128;第31卷(第1期);第38页"治疗方法"部分和"讨论"部分 * |
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