CN107929506A - A kind of capsule medicine and preparation method that can effectively treat bronchial asthma - Google Patents

A kind of capsule medicine and preparation method that can effectively treat bronchial asthma Download PDF

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Publication number
CN107929506A
CN107929506A CN201711109517.4A CN201711109517A CN107929506A CN 107929506 A CN107929506 A CN 107929506A CN 201711109517 A CN201711109517 A CN 201711109517A CN 107929506 A CN107929506 A CN 107929506A
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medicine
bronchial asthma
effectively treat
chinese
cremanthodium
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罗兴贵
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Sichuan Xingjujiao Medical Technology Co Ltd
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Sichuan Xingjujiao Medical Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268Asarum (wild ginger)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888Pinellia
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8967Lilium, e.g. tiger lily or Easter lily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds

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Abstract

The invention belongs to field of traditional Chinese, it is therefore an objective to provide a kind of capsule medicine that can effectively treat bronchial asthma according to the understanding mechanism of Chinese traditional treatment bronchial asthma, each component and its mass parts ratio of the medicine are as follows:30~100g of lepidium seed, 30~120g of tussilago, 10~40g of asarum, 25~120g of Chinese ephedra, 100~250g of ellis cremanthodium herb, 30~90g of the tuber of pinellia, 90~160g of franchet peashrub flower root, 150~350g of jujube, 150~350g of white back of the body Primula forbesii, 150~350g of gingko, 150~550g of lily, 30~150g of radix glycyrrhizae;Medicine provided by the invention is a good Chinese prescription.

Description

A kind of capsule medicine and preparation method that can effectively treat bronchial asthma
Technical field
The invention belongs to field of traditional Chinese, and in particular to a kind of capsule medicine that can effectively treat bronchial asthma, The capsule medicine particularly used for Bronchial Asthmas and the field of preparation method.
Background technology
Motherland's medicine thinks:Bronchial asthma(Referred to as:Asthma)It is a kind of common disease, frequently-occurring disease, cardinal symptom is breaking-out Property pant, it is out of breath, it is uncomfortable in chest, cough.Bronchial asthma is by various kinds of cell(Eosinophil, mast cell, T lymphs are thin Born of the same parents, neutrophil leucocyte, human airway epithelial cells etc.)The chronic airway inflammation disease participated in cellular component, this chronic inflammation It is related to airway hyperreactivity, extensive and changeable reversible airflow limitation is generally occurred within, causes the panting of recurrent exerbation, gas Promote, it is uncomfortable in chest and(Or)The symptoms such as cough, more at night and(Or)Early morning breaking-out, aggravation, most of patients can voluntarily be alleviated or through controlling Treat and alleviate.
Clinical manifestation:
One, disease symptoms
1. the common sympton of asthmatic patient be it is paroxysmal pant, be out of breath, it is uncomfortable in chest or cough etc. symptom, small number of patients be also possible to Pectoralgia is main performance, these symptoms are often in the irritation gas such as patient contact smog, perfume, paint, dust, pet, pollen Break out after body or allergen, night and(Or)Early morning symptom also easily occurs or aggravates.Many patients in asthma attack from Own audible and sound of stridulating.Symptom is typically paroxysmal, and most of patients can voluntarily be alleviated or alleviate through treatment.
2. many asthmatic patients usually undergo the mistaken diagnosis process of some time before making a definite diagnosis, chronic bronchial is diagnosed as Inflammation, pharyngitis etc., since the diagnosis of mistake causes the mistake of therapeutic scheme, not only delay treatment, the pain on body is caused to patient Hardship, also to patient bring mentally, psychological pain, paying economically also waste.And they can often make With antibiotic, since antibiotic does not have asthma therapeutic effect, Reusability be easy to cause drug resistance.Certainly bacterium infection is merged When, antibiotic can be effective.
Two, bronchial asthmas diseases endanger
1. if serious acute breaking-out occurs in asthmatic patient, possibility is fatal when giving treatment to not in time.Bad asthmatic patient is controlled to day Often work and daily life can all make a difference, and can cause to delay work, learn by mistake, cause activity, limitation of movement, make under quality of life Drop, and bring burden economically and the life to household to negatively affect.
2. asthma recurrent exerbation can cause Chronic Obstructive Pulmonary Disease, pulmonary emphysema, pulmonary heart disease, heart failure, breathing to decline The complication such as exhaust.
So, it is those skilled in the art with regard to how to find a kind of Chinese medicine composition that can effectively treat bronchial asthma The problem of urgently to be resolved.
The content of the invention
With the continuous development of China's traditional Chinese medicine, in treatment bronchial asthma, people gradually appreciate the traditional Chinese medical science The advantages for the treatment of bronchial asthma, and good effect, the advantage such as quick, toxic side effect is small over the course for the treatment of, for existing west The present situation for treating bronchial asthma is cured, the purpose of the invention is to provide a kind of capsule that can effectively treat bronchial asthma Medicine, to solve the problems, such as that Bronchial Asthmas is got well early.The medicine is using common Chinese medicine as raw material, passes through choosing Rational medicine and mass parts ratio are selected, can effectively treat above-mentioned bronchial asthma.
To achieve the purpose that foregoing invention, the technical solution adopted in the present invention is:Branch gas can effectively be treated by providing one kind The capsule medicine and preparation method of pipe asthma, it is characterised in that each component and mass parts of the medicine are than as follows:
30~100g of lepidium seed, 30~120g of tussilago, 10~40g of asarum, 25~120g of Chinese ephedra, 100~250g of ellis cremanthodium herb, 30~90g of the tuber of pinellia, 90~160g of franchet peashrub flower root, 150~350g of jujube, 150~350g of white back of the body Primula forbesii, 150~350g of gingko, 150~550g of lily, 30~150g of radix glycyrrhizae, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
A kind of capsule medicine and preparation method that can effectively treat bronchial asthma, it is characterised in that the medicine Each component and mass parts are than as follows:
38~90g of lepidium seed, 38~105g of tussilago, 12~35g of asarum, 30~105g of Chinese ephedra, 115~220g of ellis cremanthodium herb, half 38~80g of summer, 100~140g of franchet peashrub flower root, 180~310g of jujube, 180~310g of white back of the body Primula forbesii, 180~310g of gingko, 180~480g of lily, 38~130g of radix glycyrrhizae, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
A kind of capsule medicine and preparation method that can effectively treat bronchial asthma, it is characterised in that the medicine Each component and mass parts are than as follows:
Lepidium seed 80g, tussilago 95g, asarum 31g, Chinese ephedra 95g, ellis cremanthodium herb 200g, tuber of pinellia 70g, franchet peashrub flower root 120g, jujube 280g, white back of the body Primula forbesii 280g, gingko 280g, lily 420g, radix glycyrrhizae 115g, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and starch In right amount.
A kind of capsule medicine and preparation method that can effectively treat bronchial asthma, it is characterised in that the method bag Following steps are included to be prepared:
A, after above-mentioned raw materials Chinese medicine being picked impurity and dust, decoct a drug wrapped according to mass parts than being ground into graininess altogether;
B, 1. the raw material Chinese medicine wrapped is put into cold boiling water and soaks 48min, then soaked medicine is put into marmite again, The cold boiling water for adding 7~8 times of raw material Chinese medicine weight carries out first time high heat decoction, when 18min is arrived in decoction, turns slow boiling and boils 125min, leaching liquid;2. the cold boiling water for adding 6~7 times of raw material Chinese medicine weight in the dregs of a decoction again is fried by intense fire for the second time Boil, when 15min is arrived in decoction, turn slow boiling and boil 115min, leaching liquid;3. liquid mixing twice is condensed into relative density is 1.08 clear cream, it is then dry, grind with it is after disinfection to reserve;
C, the method for 1. preparing Chinese medicine capsules according to tradition, after above-mentioned ground smalls sieving, adds suitable micro mist Silica gel, microcrystalline cellulose and starch are uniformly mixed, and are then prepared into capsule(Total length is 23.3mm after its capsule is sealed, medicine Powder capacity 0.4~0.5g/), 2. then polish, sterilize, sealed packaging.
A kind of capsule medicine and preparation method that can effectively treat bronchial asthma, it is characterised in that the side of taking Method is:By the capsule medicine prepared three times a day to take, once a dose in the morning, afternoon and evening, dosage 2.4g(6)/ time, meal Half an hour after warm water delivery service.7 days as a course for the treatment of, and 4~6 courses for the treatment of of taking medicine, asthma is calmed down, and symptom is wholly absent, and disease, which is accused, fullys recover from an illness More, follow-up more than 1 year, non-goodbye recurrence.
Each raw material Chinese medicine in prescription of the present invention has detailed note in Chinese Pharmacopoeia, Chinese dictionary and China's book on Chinese herbal medicine Carry.It is raw material that the present invention, which selects one of the most common Chinese medicine, gives full play to the pharmacological effect of each component:
Lepidium seed, nature and flavor:It is pungent, bitter, cold, there is purging the lung of pathogenic fire sending down abnormally ascending, eliminating phlegm and relieving asthma, inducing diuresis for removing edema, the effect of letting out by heresy, for treating The dyspnea and cough with excessive sputum of sputum stop up lung, lung carbuncle, oedema, chest and abdomen ponding, difficult urination, chronic cor pulmonale, the asthma of heart failure The diseases such as swollen, scrofula tuberculosis;
Tussilago, nature and flavor:It is acrid flavour, micro-sweet, warm-natured, there is the effect of moistening lung to lower qi, preventing phlegm from forming and stopping coughing, for treating main new chronic cough Cough, pant, overstrain cough hemoptysis;
Asarum, nature and flavor:It is pungent, warm, there is wind-dispelling, cold dispelling, Hang Shui, the effect of having one's ideas straightened out, for treat air-cooled headache, nasosinusitis, dentalgia, Phlegm and retained fluid cough is inverse, arthralgia pain due to rheumatism;
Chinese ephedra, nature and flavor:Arduous, temperature, have sweating, relieving asthma, sharp water the effect of, for treat typhoid fever table is real, fever with chilliness is lossless, Headache nasal obstruction, arthralgia, cough and asthma, geomantic omen edema, difficult urination, the stupid numbness of ailment said due to cold or exposure, munbness, rubella itch;
Ellis cremanthodium herb, nature and flavor:Warm-natured, sweet-bitter flavor, has the effect of expelling phlegm and arresting coughing, wide chest profit gas, for treating phlegm asthma cough, internal lesion caused by overexertion And old weak headache;
The tuber of pinellia, nature and flavor:It is pungent, warm, it is poisonous, there is the effect of eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, for treating abundant expectoration cough Asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo, phlegm and headache, vomiting gastric disorder causing nausea, chest gastral cavity ruffian, globus hysteriocus, it is raw to use controlling outward carbuncle swells subcutaneous nodule, ginger half Summer is chiefly used in stopping nausea and vomiting by lowering the adverse flow of QI;
Franchet peashrub flower root, nature and flavor:It is bitter, mild-natured, there is the effect of dispelling wind and eliminating dampness, promoting blood circulation and stopping pain, for treating arthralgia pain due to rheumatism, bruise The diseases such as damage, edema, dysmenorrhoea, breast be few;
Jujube, nature and flavor:It is sweet, warm, there is tonifying spleen and stomach, nourishing generate fluid, adjust the effect of battalion defends, antidote is malicious, for treating the empty food of stomach Less, the weak loose stool of spleen, qi-blood-body fluid is insufficient, disharmony between ying and wei, palpitation and severe palpitation, married woman's stolen goods are hot-tempered;
White back of the body Primula forbesii, nature and flavor:It is pungent, micro-sweet, cool in nature, have clearing heat and detoxicating;The effect of promoting blood circulation and stopping pain, for treating lung heat cough Cough, the erosion of mucous membrane in the oral cavity, pharyngitis, red eye, swell pain, the puckery pain of dribbling urination, beat the stasis of blood swell, arthralgia pain due to rheumatism;
Gingko, nature and flavor:Sweet, bitter, puckery, mild-natured, mild toxicity, has the effect of astringing lung for relieving asthma, stop-band contracting urine, for treating asthma phlegm Cough, leukorrhea, gonorrhoea, seminal emission, frequent micturition, nameless sores or boils, Zha nose, the disease such as tinea sore;
Lily, nature and flavor:Sweet, slight bitter, be slightly cold, and has the effect of Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing, coughs long, in phlegm for treating the deficiency of Yin With blood, pyreticosis later stage, waste heat be not clear or feelings will it is unsuccessful caused by dysphoria palpitates with fear, insomnia and dreamful sleep, absent-minded, carbuncle swells, wet sore etc. Disease;
Radix glycyrrhizae, nature and flavor:It is sweet, flat, have invigorating middle warmer and replenishing QI, relieving spasm to stop pain, moisten the lung and relieve the cough, purging intense heat and detonicating, coordinating the drug actions of a prescription the effect of, use Swell in treatment burnout deficiency of food, the thin face Huang of flesh, palpitation, abdominal pain loose stool, four limbs contraction, hysteria, cough and asthma, throat Bitterly, ulcerative carbuncle swelling and pain, infant fetal toxin and medicine, food poisoning.
Medicine of the present invention is the principle based on Chinese traditional treatment bronchial asthma, from according to bronchial asthma pathomechanism and Pharmacological action is thought:With regard to bronchial asthma, each raw material herbal medicine efficacy in medicine provided by the present invention is played altogether, to above-mentioned disease There is good therapeutic effect.
Embodiment
A kind of Chinese medicine preparation that the present invention is proposed aiming at the treatment of above-mentioned bronchial asthma, is prepared using the formula Medicine effect it is good, it is quick, be a good Chinese prescription, be particularly suitable for Clinical practice.With reference to the tool of the present invention Body embodiment is described in further detail:
Embodiment 1:
A kind of capsule medicine that can effectively treat bronchial asthma, it is characterised in that each component and quality of the medicine Part is than as follows:
Lepidium seed 80g, tussilago 95g, asarum 31g, Chinese ephedra 95g, ellis cremanthodium herb 200g, tuber of pinellia 70g, franchet peashrub flower root 120g, jujube 280g, white back of the body Primula forbesii 280g, gingko 280g, lily 420g, radix glycyrrhizae 115g, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and starch In right amount.
Embodiment 2:
A kind of capsule medicine that can effectively treat bronchial asthma, it is characterised in that each component and quality of the medicine Part is than as follows:
It is lepidium seed 90g, tussilago 105g, asarum 35g, Chinese ephedra 105g, ellis cremanthodium herb 220g, tuber of pinellia 80g, franchet peashrub flower root 140g, big Jujube 310g, white back of the body Primula forbesii 310g, gingko 310g, lily 480g, radix glycyrrhizae 130g, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and shallow lake Appropriate powder.
Embodiment 3:
A kind of capsule medicine that can effectively treat bronchial asthma, it is characterised in that each component and quality of the medicine Part is than as follows:
Lepidium seed 100g, tussilago 120g, asarum 40g, Chinese ephedra 120g, ellis cremanthodium herb 250g, tuber of pinellia 90g, franchet peashrub flower root 160g, Jujube 350g, white back of the body Primula forbesii 350g, gingko 350g, lily 550g, radix glycyrrhizae 150g, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and Appropriate starch.
Model case
Through clinical conditions Bronchial Asthmas totally 1255, the age is 885 of more than 40 years old, and only 370 are 40 Year is following.850 to fully recover in 1255 patients, effective 367, invalid 38.Total effective rate is up to 97%.

Claims (3)

  1. A kind of 1. capsule medicine that can effectively treat bronchial asthma, it is characterised in that each component of the medicine and its Mass parts are than as follows:
    30~100g of lepidium seed, 30~120g of tussilago, 10~40g of asarum, 25~120g of Chinese ephedra, 100~250g of ellis cremanthodium herb, 30~90g of the tuber of pinellia, 90~160g of franchet peashrub flower root, 150~350g of jujube, 150~350g of white back of the body Primula forbesii, 150~350g of gingko, 150~550g of lily, 30~150g of radix glycyrrhizae, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
  2. 2. the capsule medicine according to claim 1 that can effectively treat bronchial asthma, it is characterised in that the medicine Each component and its mass parts than as follows:
    38~90g of lepidium seed, 38~105g of tussilago, 12~35g of asarum, 30~105g of Chinese ephedra, 115~220g of ellis cremanthodium herb, half 38~80g of summer, 100~140g of franchet peashrub flower root, 180~310g of jujube, 180~310g of white back of the body Primula forbesii, 180~310g of gingko, 180~480g of lily, 38~130g of radix glycyrrhizae, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
  3. 3. the capsule medicine that can effectively treat bronchial asthma according to claim 1 to 2, it is characterised in that described The each component and its mass parts of medicine are than as follows:
    Lepidium seed 80g, tussilago 95g, asarum 31g, Chinese ephedra 95g, ellis cremanthodium herb 200g, tuber of pinellia 70g, franchet peashrub flower root 120g, jujube 280g, white back of the body Primula forbesii 280g, gingko 280g, lily 420g, radix glycyrrhizae 115g, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and starch In right amount.
CN201711109517.4A 2017-11-11 2017-11-11 A kind of capsule medicine and preparation method that can effectively treat bronchial asthma Withdrawn CN107929506A (en)

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