CN107802691A - A kind of capsule medicine and preparation method for treating bronchial astehma - Google Patents

A kind of capsule medicine and preparation method for treating bronchial astehma Download PDF

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Publication number
CN107802691A
CN107802691A CN201711109329.1A CN201711109329A CN107802691A CN 107802691 A CN107802691 A CN 107802691A CN 201711109329 A CN201711109329 A CN 201711109329A CN 107802691 A CN107802691 A CN 107802691A
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medicine
bronchial astehma
chinese
capsule
achene
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孙思远
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Sichuan Yichuang Biotechnology Co Ltd
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Sichuan Yichuang Biotechnology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/748Oldenlandia or Hedyotis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/78Saururaceae (Lizard's-tail family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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Abstract

The invention belongs to field of traditional Chinese, it is therefore an objective to provide a kind of capsule medicine for treating bronchial astehma according to the understanding mechanism of Chinese traditional treatment bronchial astehma, each component and its mass parts ratio of the medicine are as follows:30~100g of the achene of Siberian cocklebur, 100~160g of ardisia japonica, 90~160g of ceylon leucas herb, 90~160g of Poria cocos, 150~280g of Chinese wampee leaf, 250~1200g of oldenlandia diffusa, 150~280g of cordate houttuynia;Medicine provided by the invention is a good Chinese prescription.

Description

A kind of capsule medicine and preparation method for treating bronchial astehma
Technical field
The invention belongs to field of traditional Chinese, and in particular to a kind of capsule medicine for treating bronchial astehma, particularly The capsule medicine used for Bronchial Asthmas and the field of preparation method.
Background technology
Motherland's medical science thinks:Bronchial astehma(Referred to as:Asthma)It is a kind of common disease, frequently-occurring disease, cardinal symptom is breaking-out Property pant, it is out of breath, it is uncomfortable in chest, cough.Bronchial astehma is by various kinds of cell(Eosinophil, mast cell, T lymphs are thin Born of the same parents, neutrophil leucocyte, human airway epithelial cells etc.)The chronic airway inflammation disease participated in cellular component, this chronic inflammation It is related to airway hyperreactivity, extensive and changeable reversible airflow limitation is generally occurred within, causes the panting of recurrent exerbation, gas Promote, it is uncomfortable in chest and(Or)The symptoms such as cough, more at night and(Or)Early morning breaking-out, aggravation, most of patients can voluntarily be alleviated or through controlling Treat and alleviate.
Clinical manifestation:
One, disease symptomses
1. the common sympton of asthmatic patient be it is paroxysmal pant, be out of breath, it is uncomfortable in chest or cough etc. symptom, small number of patients be also possible to Pectoralgia is main performance, and these symptoms are often in the excitant gas such as patient contact smog, perfume, paint, dust, pet, pollen Broken out after body or allergen, night and(Or)Early morning symptom also easily occurs or aggravated.Many patients in asthma attack from Own audible and sound of stridulating.Symptom is typically paroxysmal, and most of patients can voluntarily be alleviated or alleviate through treatment.
2. many asthmatic patients usually undergo the mistaken diagnosis process of some time before making a definite diagnosis, chronic bronchial is diagnosed as Inflammation, pharyngitis etc., because the diagnosis of mistake causes the mistake of therapeutic scheme, not only delay treatment, the pain on body is caused to patient Hardship, also to patient bring mentally, psychological pain, paying economically also waste.And they can often make With antibiotic, because antibiotic does not have therapeutic action to asthma, Reusability easily causes resistance.Certainly bacterium infection is merged When, antibiotic can be effective.
Two, bronchial asthmas diseases endanger
1. if serious acute breaking-out occurs in asthmatic patient, possibility is fatal when giving treatment to not in time.Bad asthmatic patient is controlled to day Often work and daily life can all make a difference, and can cause to delay work, learn by mistake, cause activity, limitation of movement, make under quality of life Drop, and bring burden economically and the life to household to negatively affect.
2. asthma recurrent exerbation can cause COPD, pulmonary emphysema, pulmonary heart disease, heart failure, breathing to decline The complication such as exhaust.
So, it is those skilled in the art with regard to how to find a kind of Chinese medicine composition that can effectively treat bronchial astehma The problem of urgently to be resolved.
The content of the invention
With the continuous development of China's traditional Chinese medicine, in treatment bronchial astehma, people gradually appreciate the traditional Chinese medical science The advantages for the treatment of bronchial astehma, and good effect, the advantage such as quick, toxic side effect is small over the course for the treatment of, for existing west The present situation for treating bronchial astehma is cured, the purpose of the present invention is to be to provide a kind of capsule medicine for treating bronchial astehma, To solve the problems, such as that Bronchial Asthmas is got well early.The medicine is using common Chinese medicine as raw material, by selecting to close Medicine and the mass parts ratio of reason, it can effectively treat above-mentioned bronchial astehma one and demonstrate,prove.
To reach the purpose of foregoing invention, the technical solution adopted in the present invention is:One kind is provided and treats bronchial astehma Capsule medicine and preparation method, it is characterised in that each component and mass parts of the medicine are than as follows:
30~100g of the achene of Siberian cocklebur, 100~160g of ardisia japonica, 90~160g of ceylon leucas herb, 90~160g of Poria cocos, Chinese wampee leaf 150~ 280g, 250~1200g of oldenlandia diffusa, 150~280g of cordate houttuynia, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
A kind of capsule medicine and preparation method for treating bronchial astehma, it is characterised in that each group of the medicine Divide and mass parts are than as follows:
38~90g of the achene of Siberian cocklebur, 115~140g of ardisia japonica, 100~140g of ceylon leucas herb, 100~140g of Poria cocos, Chinese wampee leaf 180~ 250g, 280~1000g of oldenlandia diffusa, 180~250g of cordate houttuynia, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
A kind of capsule medicine and preparation method for treating bronchial astehma, it is characterised in that each group of the medicine Divide and mass parts are than as follows:
Achene of Siberian cocklebur 80g, ardisia japonica 120g, ceylon leucas herb 120g, Poria cocos 120g, Chinese wampee leaf 220g, oldenlandia diffusa 850g, cordate houttuynia 220g, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
A kind of capsule medicine and preparation method for treating bronchial astehma, it is characterised in that methods described includes as follows Step is prepared:
A, after above-mentioned raw materials Chinese medicine being picked into impurity and dust, decocted a drug wrapped according to mass parts than being ground into graininess altogether;
B, 1. the raw material Chinese medicine wrapped is put into cold boiling water and soaks 56min, then soaked medicine is put into marmite again, The cold boiling water for adding 7~9 times of raw material Chinese medicine weight carries out first time high heat decoction, when 18min is arrived in decoction, turns slow fire and boils 125min, leaching decoction;2. the cold boiling water for adding 6~8 times of raw material Chinese medicine weight in the dregs of a decoction again is fried by intense fire for the second time Boil, when 15min is arrived in decoction, turn slow fire and boil 115min, leaching decoction;3. decoction mixing twice is condensed into relative density is 1.08 clear cream, then dry, grind and sterilize after it is standby;
C, the method for 1. preparing Chinese medicine capsules according to tradition, after above-mentioned ground smalls sieving, appropriate micro mist is added Silica gel, microcrystalline cellulose and starch are well mixed, and are then prepared into capsule(Total length is 23.3mm after its capsule is sealed, medicine Powder capacity 0.4~0.5g/ grains), 2. then polish, sterilize, sealed packaging.
A kind of capsule medicine and preparation method for treating bronchial astehma, it is characterised in that the instructions of taking is:Will The capsule medicine prepared is three times a day to take, and once a dose in the morning, afternoon and evening, dosage 3g(6)/ time, half an hour after meal Clothes.7 days are a course for the treatment of, and 5~8 courses for the treatment of of taking medicine, asthma is calmed down, and breathing is normal, and symptom all disappears, and disease obtains recovery from illness, so far No relapse.
Each raw material Chinese medicine in prescription of the present invention has detailed note in Chinese Pharmacopoeia, Chinese dictionary and China's book on Chinese herbal medicine Carry.The present invention is raw material from most common of which Chinese medicine, gives full play to the pharmacological effect of each component:
The achene of Siberian cocklebur, nature and flavor:It is bitter, sweet, pungent, warm-natured, there is the effect of expelling cold, eliminating, clearing the nasal passage, wind-damp dispelling, analgesic, for controlling Treat the card such as anemofrigid cold, nasosinusitis, arthralgia pain due to rheumatism, rubella itch;
Ardisia japonica, nature and flavor:Mild-natured, acrid flavour, slight bitter, there is the effect of preventing phlegm from forming and stopping coughing, dampness removing, promoting blood circulation, for treating in cough, phlegm Band blood, chronic bronchitis, jaundice with damp-heat pathogen, injury from falling down;
Ceylon leucas herb, nature and flavor:It is pungent, bitter, flat, there is removing toxic substances, cough-relieving, improving eyesight, the effect of stimulating the menstrual flow, for treating flu, headache, heavy breathing Asthma, pertussis, abscess of throat, toothache, indigestion, irregular menstruation, Amenorrhea, yctalopia, cellular furuncle;
Poria cocos, nature and flavor:It is sweet, light, flat, have clearing damp and promoting diuresis, invigorating the spleen calming heart the effect of, for treat oedema oliguria, phlegm retention anti-dazzle nervous, Spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear;
Chinese wampee leaf, nature and flavor:It is bitter, pungent, flat, there is the effect of expelling wind to resolve the exterior, eliminating phlegm promoting the circulation of qi, for treating warm disease body heat, cough is roared Asthma, inflatable stomachache, yellow swollen, malaria, difficult urination, heat toxin scabies leprosy;
Oldenlandia diffusa, nature and flavor:It is sweet, light, cool, there is the effect of clearing heat and detoxicating, inducing diuresis to remove edema, promoting blood circulation and stopping pain, for treating intestines Carbuncle(Appendicitis), sore furuncle poison, jaundice with damp-heat pathogen, disease, the external application such as difficult urination control boil carbuncle swells, venomous snake bite;
Cordate houttuynia, nature and flavor:It is acrid flavour, cold, there is clearing heat and detoxicating, row's pain detumescence to treat sore, promoting urination and removing dampness, the work(of stomach strengthening and digestion promoting Effect, it is the diseases such as the lung carbuncle of trouble, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach for treating real heat, heat toxin, damp evil, disease heat.
Medicine of the present invention is the principle based on Chinese traditional treatment bronchial astehma, from according to bronchial astehma pathomechanism and Pharmacological action is thought:With regard to bronchial astehma, each raw material herbal medicine efficacy in medicine provided by the present invention is played altogether, to above-mentioned disease There is good therapeutic effect.
Embodiment
A kind of Chinese medicine preparation that the present invention proposes aiming at the treatment of above-mentioned bronchial astehma, prepared using the formula Medicine effect it is good, it is quick, be a good Chinese prescription, be particularly suitable for Clinical practice.With reference to the tool of the present invention Body embodiment is described in further detail:
Embodiment 1:
A kind of capsule medicine for treating bronchial astehma, it is characterised in that each component and mass parts of the medicine are such as Shown in lower:
Achene of Siberian cocklebur 80g, ardisia japonica 120g, ceylon leucas herb 120g, Poria cocos 120g, Chinese wampee leaf 220g, oldenlandia diffusa 850g, cordate houttuynia 220g, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
Embodiment 2:
A kind of capsule medicine for treating bronchial astehma, it is characterised in that each component and mass parts of the medicine are such as Shown in lower:
Achene of Siberian cocklebur 90g, ardisia japonica 140g, ceylon leucas herb 140g, Poria cocos 140g, Chinese wampee leaf 250g, oldenlandia diffusa 1000g, fish raw meat Careless 250g, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
Embodiment 3:
A kind of capsule medicine for treating bronchial astehma, it is characterised in that each component and mass parts of the medicine are such as Shown in lower:
Achene of Siberian cocklebur 100g, ardisia japonica 160g, ceylon leucas herb 160g, Poria cocos 160g, Chinese wampee leaf 280g, oldenlandia diffusa 1200g, fish raw meat Careless 280g, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
Model case
Through clinical conditions Bronchial Asthmas totally 1230, the age is 837 of more than 57 years old, and only 393 are 57 Year is following.850 to be fully recovered in 1230 patients, effective 331, invalid 49.Total effective rate is up to 96%.

Claims (3)

1. a kind of capsule medicine for treating bronchial astehma, it is characterised in that each component and its mass parts of the medicine Than as follows:
30~100g of the achene of Siberian cocklebur, 100~160g of ardisia japonica, 90~160g of ceylon leucas herb, 90~160g of Poria cocos, Chinese wampee leaf 150~ 280g, 250~1200g of oldenlandia diffusa, 150~280g of cordate houttuynia, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
2. it is according to claim 1 treatment bronchial astehma capsule medicine, it is characterised in that the medicine it is each Component and its mass parts are than as follows:
38~90g of the achene of Siberian cocklebur, 115~140g of ardisia japonica, 100~140g of ceylon leucas herb, 100~140g of Poria cocos, Chinese wampee leaf 180~ 250g, 280~1000g of oldenlandia diffusa, 180~250g of cordate houttuynia, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
3. the capsule medicine of the treatment bronchial astehma according to claim 1 to 2, it is characterised in that the medicine Each component and its mass parts are than as follows:
Achene of Siberian cocklebur 80g, ardisia japonica 120g, ceylon leucas herb 120g, Poria cocos 120g, Chinese wampee leaf 220g, oldenlandia diffusa 850g, cordate houttuynia 220g, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
CN201711109329.1A 2017-11-11 2017-11-11 A kind of capsule medicine and preparation method for treating bronchial astehma Withdrawn CN107802691A (en)

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Application Number Priority Date Filing Date Title
CN201711109329.1A CN107802691A (en) 2017-11-11 2017-11-11 A kind of capsule medicine and preparation method for treating bronchial astehma

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