CN115089689A

CN115089689A - Traditional Chinese medicine composition for treating spasmodic cough and preparation method and application thereof

Info

Publication number: CN115089689A
Application number: CN202210864533.9A
Authority: CN
Inventors: 韩雪; 潘丹萍
Original assignee: Henan Childrens Hospital Zhengzhou Childrens Hospital
Current assignee: Henan Childrens Hospital Zhengzhou Childrens Hospital
Priority date: 2022-07-22
Filing date: 2022-07-22
Publication date: 2022-09-23
Anticipated expiration: 2042-07-22
Also published as: CN115089689B

Abstract

The invention provides a traditional Chinese medicine composition for treating spasmodic cough and a preparation method and application thereof, belonging to the technical field of traditional Chinese medicines, and the traditional Chinese medicine composition comprises the following components in parts by weight: 6-12 parts of radix bupleuri, 6-10 parts of radix paeoniae alba, 6-12 parts of fructus aurantii, 3-9 parts of liquorice, 10-15 parts of cortex mori radicis, 10-15 parts of cortex lycii radicis, 3-6 parts of rhizoma zingiberis, 6-10 parts of fructus schizandrae, 10-20 parts of rhizoma phragmitis, 6-10 parts of inula flower, 10-15 parts of bitter almond, 5-10 parts of ephedra, 6-10 parts of periostracum cicadae and 10-15 parts of stiff silkworm. The Chinese medicinal composition has a better treatment effect on spasmodic cough of infants and children, can obviously improve the attack frequency and duration of cough, reduce the recurrence rate and reduce the occurrence of severe cough, and has low cost and small side effect compared with western medicine treatment.

Description

Traditional Chinese medicine composition for treating spasmodic cough and preparation method and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating spasmodic cough and a preparation method and application thereof.

Background

The spasmodic cough is a common lung symptom of infants and children, the condition of the cough is heavier when the infants and children are younger, complications are easy to cause, the initial stage of the symptom is very similar to a cold symptom, the cough is easy to miss treatment and mistreat, the western medicine mainly treats the disease by resisting infection, no specific medicine is available, and the western medicine has high cost and great side effect.

Spasmodic cough is common in clinic, the incidence rate is increased year by year, the spasmodic cough is often caused by various factors such as infection, allergy and the like, the medical history is long, the illness state is easy to repeat, the life quality of children patients is seriously affected, and the conventional anti-infection and symptomatic treatment effects are not ideal. The spasmodic cough belongs to the scope of 'cough' in the traditional Chinese medicine, and the clinical traditional Chinese medicine treatment can obviously improve the attack frequency and duration of the spasmodic cough, reduce the recurrence rate and reduce the occurrence of severe cough. However, because the treatment based on syndrome differentiation is taught in the treatment of diseases with traditional Chinese medicines, doctors have the condition of non-uniform syndrome differentiation and medication for the treatment of most diseases with traditional Chinese medicines. The therapeutic effect of spasmodic cough is difficult to judge because of different views and different levels of doctors, and besides, a series of cough-relieving and phlegm-resolving Chinese patent medicine preparations are applied to a certain proportion of children patients, so that the core pathogenesis of the disease cannot be accurately grasped by the Chinese patent medicine preparations, and the therapeutic effect is difficult to judge.

Therefore, it is desirable to provide a Chinese medicinal composition for treating spasmodic cough, and a preparation method and application thereof, so as to solve the existing problems.

Disclosure of Invention

In view of this, the invention provides a traditional Chinese medicine composition for treating spasmodic cough, and a preparation method and application thereof, which can obviously improve the attack frequency and duration of cough, reduce the recurrence rate and reduce the occurrence of severe cough.

In order to achieve the technical effects, the invention provides a traditional Chinese medicine composition for treating spasmodic cough and a preparation method and application thereof, and the following technical scheme is adopted:

a traditional Chinese medicine composition for treating spasmodic cough comprises the following components in parts by weight: 6-12 parts of radix bupleuri, 6-10 parts of radix paeoniae alba, 6-12 parts of fructus aurantii, 3-9 parts of liquorice, 10-15 parts of cortex mori radicis, 10-15 parts of cortex lycii radicis, 3-6 parts of rhizoma zingiberis, 6-10 parts of fructus schizandrae, 10-20 parts of rhizoma phragmitis, 6-10 parts of inula flower, 10-15 parts of bitter almond, 5-10 parts of ephedra, 6-10 parts of periostracum cicadae and 10-15 parts of stiff silkworm.

Further, the paint comprises the following components in parts by weight: 6 parts of radix bupleuri, 10 parts of radix paeoniae alba, 6 parts of fructus aurantii, 3 parts of liquorice, 10 parts of cortex mori radicis, 10 parts of cortex lycii radicis, 5 parts of rhizoma zingiberis, 6 parts of schisandra chinensis, 10 parts of rhizoma phragmitis, 6 parts of inula flower, 10 parts of bitter almond, 5 parts of ephedra, 6 parts of periostracum cicada and 10 parts of stiff silkworm.

The preparation method of the traditional Chinese medicine composition for treating spasmodic cough comprises the following steps: weighing radix bupleuri, radix paeoniae alba, fructus aurantii, liquorice, cortex mori radicis, cortex lycii radicis, rhizoma zingiberis, schisandra chinensis, rhizoma phragmitis, inula flower, bitter apricot seeds, ephedra, periostracum cicada and stiff silkworms in parts by weight, soaking in water, decocting for 2 times, combining water decoctions, filtering, and collecting filtrate to obtain the traditional Chinese medicine composition.

The application of the traditional Chinese medicine composition for treating spasmodic cough in preparing a traditional Chinese medicine preparation is characterized in that the traditional Chinese medicine preparation is prepared by adding conventional auxiliary materials into the traditional Chinese medicine composition serving as an active component.

Further, the traditional Chinese medicine preparation is decoction, oral liquid, tablets, capsules or granules;

the adjuvant is selected from pharmaceutically acceptable excipient, diluent, stabilizer, antiseptic and correctant.

Further, the traditional Chinese medicine preparation is a decoction, and the specific preparation method is as follows: weighing radix bupleuri, radix paeoniae alba, fructus aurantii, liquorice, cortex mori radicis, cortex lycii radicis, rhizoma zingiberis, fructus schizandrae, rhizoma phragmitis, inula japonica, bitter apricot seeds, ephedra, periostracum cicadae and stiff silkworm according to parts by weight, adding water to be 2-3cm higher than decoction pieces, soaking for 20-30 minutes, boiling with strong fire, decocting with slow fire for 20-30 minutes, decocting twice for each medicine, extruding medicine residues after the second decoction, and decocting out 100 ml of liquid.

Further, the traditional Chinese medicine preparation is oral liquid, and the specific preparation method is as follows: weighing radix bupleuri, radix paeoniae alba, fructus aurantii, liquorice, cortex mori radicis, cortex lycii radicis, rhizoma zingiberis, fructus schizandrae, rhizoma phragmitis, inula japonica, bitter apricot seeds, ephedra, periostracum cicada and stiff silkworm in parts by weight, adding water for decocting twice, wherein the water addition amount is respectively 8 times and 6 times of the total weight of the medicinal materials, soaking for 0.5 hour, decocting for 1.5 hours and 1 hour respectively, combining the water decoctions for two times, filtering, concentrating the filtrate to a liquid medicine with the relative density of 1.05-1.08g/ml at 60 ℃, adding 0.5% of sodium benzoate, cooling, filtering, uniformly stirring, encapsulating and sterilizing to obtain the (without sucrose).

Further, the traditional Chinese medicine preparation is a tablet, and the specific preparation method is as follows: weighing radix bupleuri, radix paeoniae alba, fructus aurantii, liquorice, cortex mori radicis, cortex lycii radicis, rhizoma zingiberis, fructus schizandrae, rhizoma phragmitis, inus inula flower, bitter apricot seed, ephedra, periostracum cicadae and stiff silkworm in parts by weight, adding water in an amount which is 8 times and 6 times of the total weight of the medicinal materials, soaking for 0.5 hour, respectively decocting for 1.5 hours and 1 hour, combining the water decoctions, filtering, concentrating the filtrate to thick medicinal paste with the relative density of 1.35-1.40g/ml at 60 ℃, vacuum drying at the temperature of below 80 ℃, crushing to 100 meshes, adding 10% of microcrystalline cellulose and 1% of starch slurry, granulating, drying at the temperature of 80 ℃, adding 3% of magnesium stearate and 3% of sodium carboxymethyl starch, uniformly mixing and pressing into tablets, and coating to obtain the Chinese medicinal composition.

Further, the traditional Chinese medicine preparation is a capsule, and the specific preparation method is as follows: weighing radix bupleuri, radix paeoniae alba, fructus aurantii, liquorice, cortex mori radicis, cortex lycii radicis, rhizoma zingiberis, fructus schizandrae, rhizoma phragmitis, inula japonica, bitter apricot seeds, ephedra, periostracum cicada and stiff silkworm in parts by weight, adding water for decocting twice, wherein the water addition amount is respectively 8 times and 6 times of the total weight of the medicinal materials, soaking for 0.5 hour, decocting for 1.5 hours and 1 hour respectively, combining the water decoctions, filtering, concentrating the filtrate to thick ointment with the relative density of 1.35-1.40g/ml at 60 ℃, drying in vacuum at the temperature of below 80 ℃, crushing to 40 meshes, adding 5% of microcrystalline cellulose and 5% of talc magnesium, mixing uniformly, and filling into capsules.

Further, the traditional Chinese medicine preparation is granules, and the specific preparation method is as follows: weighing radix bupleuri, radix paeoniae alba, fructus aurantii, liquorice, cortex mori radicis, cortex lycii radicis, rhizoma zingiberis, schisandra chinensis, rhizoma phragmitis, inula flower, bitter apricot seed, ephedra herb, cicada slough and stiff silkworm according to parts by weight, adding water for decocting twice, wherein the water addition amount is 8 times and 6 times of the total weight of the medicinal materials respectively, soaking for 0.5 hour, decocting for 1.5 hours and 1 hour respectively, combining the water decoction of the two times, filtering, concentrating the filtrate to thick medicinal paste with the relative density of 1.35-1.40g/ml at 60 ℃, adding 20% of dextrin and 5% of stevioside, granulating by 12 meshes, drying at 80 ℃, finishing granules and subpackaging.

The technical scheme of the invention at least comprises the following beneficial effects:

1. the invention takes radix bupleuri and white paeony root as monarch drugs, and is dissolved and cut in the sini powder of Shang Han Lun, the radix bupleuri soothes liver-qi stagnation and transmits heat, the white paeony root nourishes blood, converges yin and softens liver, the two drugs rise and converge one after the other, and the effects of transmitting stagnated heat and regulating liver qi are achieved;

fructus aurantii, cortex mori radicis, cortex lycii radicis, ephedra, bitter apricot seed, periostracum cicadae and stiff silkworm are used as ministerial drugs, and the fructus aurantii in the formula has the effects of regulating qi, relieving epigastric distention and settling and is used for regulating the qi activity of the whole body together with the radix bupleuri; cortex mori can purge lung and relieve asthma, cortex lycii radicis can clear lung and reduce fire to enter lung and liver channels, and the two medicines can clear lung heat and purge lung and descend the adverse qi, so that the effect of purging white is achieved; the ephedra stem disperses lung qi, the bitter apricot seed can reduce lung qi, and the two medicines are used together to regulate lung qi, relieve cough and reduce sputum; cicada slough and stiff silkworm dispel wind, relieve spasm and cough, and regulate the ascending and descending of qi movement, and the combination of the medicines achieves the effects of purging lung, lowering adverse qi, reducing phlegm and regulating qi movement;

the reed rhizome, the inula flower, the dried ginger and the Chinese magnoliavine fruit are adjuvant drugs, in the formula, the reed rhizome clears lung heat, the inula flower promotes blood circulation, removes stasis and turbid, clears qi channels and purges phlegm and retained fluid, the dried ginger and the Chinese magnoliavine fruit lower the adverse flow of lung and relieve cough, and the dried ginger has the function of warming and drying spleen soil;

the liquorice is used for eliminating phlegm and relieving cough, relieving urgency and regulating the middle warmer and harmonizing the other medicines;

the medicines are combined to play the roles of dispersing liver qi, purging lung and resolving phlegm.

2. The invention takes liver qi regulation, lung dispersing, purifying and descending normal and spasmodic cough self-stopping as theoretical basis, and adopts the methods of soothing liver, descending qi, purging lung and reducing phlegm to treat infant cough, and liver and lung are treated simultaneously, thereby effectively achieving the purposes of spasmolysis and cough relieving.

3. The Chinese medicinal composition has a better treatment effect on spasmodic cough of infants and children, can obviously improve the attack frequency and duration of cough, reduce the recurrence rate and reduce the occurrence of severe cough, and has low cost and small side effect compared with western medicine treatment.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below. It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the described embodiments of the invention, are within the scope of the invention.

Example 1

A traditional Chinese medicine composition for treating spasmodic cough is prepared from the following raw materials: 6g of radix bupleuri, 10g of radix paeoniae alba, 6g of fructus aurantii, 3g of liquorice, 10g of cortex mori radicis, 10g of cortex lycii radicis, 5g of rhizoma zingiberis, 6g of fructus schizandrae, 10g of rhizoma phragmitis, 6g of inula flower, 10g of bitter almond, 5g of herba ephedrae, 6g of periostracum cicada and 10g of stiff silkworm.

The Chinese medicinal composition can be prepared into decoction, and the preparation method comprises the following steps:

weighing bupleuri radix, radix Paeoniae alba, fructus Aurantii, Glycyrrhrizae radix, cortex Mori, cortex Lycii, Zingiberis rhizoma, fructus Schisandrae chinensis, rhizoma Phragmitis, Inulae flos, semen Armeniacae amarum, herba Ephedrae, periostracum Cicadae, and Bombyx Batryticatus, adding water 2-3cm above the surface of the medicinal materials, soaking for 30min, boiling with strong fire, decocting with slow fire for 30min, decocting for 2 times, mixing decoctions, filtering, and administering for 2-3 times.

Example 2

A traditional Chinese medicine composition for treating spasmodic cough is prepared from the following raw materials: 24g of radix bupleuri, 20g of radix paeoniae alba, 12g of fructus aurantii, 6g of liquorice, 20g of cortex mori radicis, 20g of cortex lycii radicis, 10g of rhizoma zingiberis, 12g of fructus schizandrae, 20g of rhizoma phragmitis, 12g of inula flower, 20g of bitter apricot seed, 10g of herba ephedrae, 12g of periostracum cicadae and 20g of stiff silkworm.

The Chinese medicinal composition can be prepared into granules, and the specific preparation method comprises the following steps:

weighing radix bupleuri, radix paeoniae alba, fructus aurantii, liquorice, cortex mori radicis, cortex lycii radicis, rhizoma zingiberis, schisandra chinensis, rhizoma phragmitis, inula flower, bitter apricot seed, ephedra, periostracum cicada and stiff silkworm, adding water which is 8 times of the total weight of the medicinal materials, soaking for 0.5h, decocting for 1.5h, filtering, collecting first decoction, adding water which is 6 times of the total weight of the medicinal materials into filter residues, decocting for 1h, filtering, collecting second decoction, combining the two decoctions, concentrating to thick ointment with the relative density of 1.35-1.40g/ml at 60 ℃, sequentially adding 20% of dextrin and 5% of stevioside according to the mass fraction, uniformly mixing, sieving by a 12-mesh medicine sieve, granulating, drying at 80 ℃, grading and subpackaging.

Example 3

A traditional Chinese medicine composition for treating spasmodic cough is prepared from the following raw materials: 24g of radix bupleuri, 20g of radix paeoniae alba, 12g of fructus aurantii, 6g of liquorice, 20g of cortex mori radicis, 20g of cortex lycii radicis, 10g of rhizoma zingiberis, 12g of fructus schizandrae, 20g of rhizoma phragmitis, 12g of inula flower, 20g of bitter apricot seed, 12g of ephedra herb, 12g of periostracum cicada and 20g of stiff silkworm.

The Chinese medicinal composition can be prepared into oral liquid, and the preparation method comprises the following steps:

weighing radix bupleuri, radix paeoniae alba, fructus aurantii, liquorice, cortex mori radicis, cortex lycii radicis, rhizoma zingiberis, schisandra chinensis, rhizoma phragmitis, inula flower, bitter apricot seed, ephedra, cicada slough and stiff silkworm, adding water with the weight 8 times of the total weight of the medicinal materials, soaking for 0.5h, decocting for 1.5h, filtering, collecting first decoction, adding water with the weight 6 times of the total weight of the medicinal materials into filter residues, decocting for 1h, filtering, collecting second decoction, combining the two decoctions, concentrating to liquid medicine with the relative density of 1.05-1.08g/ml at 60 ℃, adding 0.5% of sodium benzoate according to the mass fraction, cooling, filtering, uniformly stirring, encapsulating and sterilizing to obtain the traditional Chinese medicine.

Example 4

A traditional Chinese medicine composition for treating spasmodic cough is prepared from the following raw materials: 24g of radix bupleuri, 20g of radix paeoniae alba, 12g of fructus aurantii, 6g of liquorice, 20g of cortex mori radicis, 20g of cortex lycii radicis, 6g of rhizoma zingiberis, 12g of fructus schizandrae, 20g of rhizoma phragmitis, 12g of inula flower, 20g of bitter apricot seed, 12g of ephedra herb, 12g of periostracum cicada and 20g of stiff silkworm.

The traditional Chinese medicine composition can be prepared into tablets, and the specific preparation method comprises the following steps:

weighing radix bupleuri, radix paeoniae alba, fructus aurantii, liquorice, cortex mori radicis, cortex lycii radicis, rhizoma zingiberis, schisandra chinensis, rhizoma phragmitis, inula flower, bitter apricot seed, ephedra, cicada slough and stiff silkworm, adding water with the weight 8 times of the total weight of the medicinal materials, soaking for 0.5h, decocting for 1.5h, filtering, collecting first decoction, adding water with the weight 6 times of the total weight of the medicinal materials into filter residues, decocting for 1h, filtering, collecting second decoction, combining the two decoctions, concentrating to thick paste with the relative density of 1.35-1.40g/ml at 60 ℃, drying in vacuum at the temperature of below 80 ℃, crushing, sieving by a 100-mesh sieve, adding 10% of microcrystalline cellulose and 1% of starch slurry according to mass fraction, granulating, drying at the temperature of 80 ℃, adding 3% of magnesium stearate and 3% of sodium carboxymethyl starch according to mass fraction, uniformly mixing, pressing into tablets, and coating the tablets.

Example 5

A traditional Chinese medicine composition for treating spasmodic cough is prepared from the following raw materials: 3g of radix bupleuri, 5g of radix paeoniae alba, 3g of fructus aurantii, 2g of liquorice, 5g of cortex mori radicis, 5g of cortex lycii radicis, 2g of rhizoma zingiberis, 3g of schisandra chinensis, 5g of rhizoma phragmitis, 3g of inula flower, 5g of bitter almond, 3g of ephedra, 3g of periostracum cicada and 5g of stiff silkworm.

The Chinese medicinal composition can be prepared into decoction by the following specific preparation method:

Example 6

A traditional Chinese medicine composition for treating spasmodic cough is prepared from the following raw materials: 4g of radix bupleuri, 6g of radix paeoniae alba, 4g of fructus aurantii, 2g of liquorice, 6g of cortex mori radicis, 6g of cortex lycii radicis, 2g of rhizoma zingiberis, 4g of schisandra chinensis, 6g of rhizoma phragmitis, 4g of inula flower, 6g of bitter apricot kernel, 4g of ephedra, 4g of periostracum cicada and 6g of stiff silkworm.

Example 7

A traditional Chinese medicine composition for treating spasmodic cough is prepared from the following raw materials: 9g of radix bupleuri, 15g of radix paeoniae alba, 9g of fructus aurantii, 5g of liquorice, 15g of cortex mori radicis, 15g of cortex lycii radicis, 5g of rhizoma zingiberis, 9g of fructus schizandrae, 15g of rhizoma phragmitis, 9g of inula flower, 15g of bitter apricot seed, 9g of herba ephedrae, 9g of periostracum cicadae and 15g of stiff silkworm.

Comparative example 1

Commercially available erythromycin ethylsuccinate particles are used in combination with an aerosolized budesonide suspension and a terbutaline sulfate suspension.

Test example 1

1. Case selection

The children with spasmodic cough treated in 06-2022 in 2021 are selected for clinical observation and randomly divided into treatment groups 1-7 and control group 1, wherein the average course of disease (21.94 + -12.52) days in the treatment groups 1-7 and the average course of disease (19.77 + -12.33) days in the control group 1, and the age, course and severity of symptoms of all the cases are basically consistent, have no significant difference and are comparable.

2. Method of administration

Treatment groups 1-7: examples 1-7, 7 doses were used, respectively, 1 dose daily.

Control group 1: use comparative example 1, erythromycin ethylsuccinate granules (10-12.5 mg/kg/dose), 4 times daily for 7 consecutive days of oral administration; 1mg of budesonide suspension is atomized for each time, 1 time in the morning and at night, 2.5mg of terbutaline sulfate suspension is atomized for each time, 1 time in the morning and at night.

3. Basis for diagnosis

Reference is made to the diagnostic criteria of infant tussive cough (spasmodic cough):

(1) the main symptoms are: cough is paroxysmal, light day and heavy night, the face is red and eyes are red when the cough is produced, the nasal discharge and the tears are communicated, even the cough is spitted, and the roar is caused after the cough; the secondary symptoms are as follows: mental fatigue, bloody sputum, epistaxis, ulcer of the tongue and anorexia.

(2) The early stage of the disease may have the appearance similar to the common cold.

(3) Fingerprint of tongue pulse: red or purple tongue with thin yellow or yellow greasy coating, rapid and forceful pulse, and purple stagnation of the finger prints, which can be seen in the three joints.

(4) The spring is more in winter and spring. Is good for infants, and has the characteristics of acute onset, rapid transmission and long course of disease.

4. Observation index

The improvement of the main symptoms such as the attack frequency of spasmodic cough, the duration of spasmodic cough, vomiting and the like is observed, and the symptoms are respectively rated as 0, 1, 3 and 6 according to the severity of the symptoms and according to the non, mild, moderate and severe degrees.

5. Determination of therapeutic effect

(1) And (3) clinical recovery: cough and other symptoms disappear or basically disappear, and the main symptom score is reduced by more than or equal to 75 percent;

(2) the effect is shown: the spasmodic cough symptom is not appeared any more, the occasional cough with little phlegm is shown, the main symptom score is reduced by more than or equal to 50 percent but less than 75 percent;

(3) the method has the following advantages: the spasmodic cough symptom is reduced, paroxysmal cough occasionally occurs, and the main symptom score is reduced by more than or equal to 25 percent but less than 50 percent;

(4) and (4) invalidation: the clinical symptoms are not obviously improved, and the integral of the main symptoms is reduced by less than 25 percent.

6. Therapeutic results

The treatment results are shown in table 1 and table 2;

table 1 shows the comparison of the post-treatment chief symptom score x ± s, min) for examples 1-7 and comparative example 1;

table 2 shows the comparison of the therapeutic effects of examples 1 to 7 and comparative example 1 after the treatment.

TABLE 1

Note: ^* shows that P < 0.05

TABLE 2

As can be seen from tables 1 and 2, the Chinese medicinal composition provided by the application has a better treatment effect on spasmodic cough. The clinical application shows that the traditional Chinese medicine composition provided by the application can obviously shorten the treatment time and has a larger clinical application value.

Typical cases

Case 1

The infant is concerned with admission in the first place of 'cough for 2 weeks, aggravation with cough and suffocation for 3 days, fever for half a day' in 4 months, with symptoms as follows: fever, body temperature fluctuation at 37-37.5 deg.C, cough with paroxysmal spasmodic chest cough, red eyes behind the cough accompanied by deep-inhalation chicken singing, even vomiting, sputum and food, light day and heavy night, repeated cough at night, difficulty in falling asleep, poor diet, 3 times of stool, watery stool, and scanty urine. Physical examination: red tongue, white coating, purple fingerprint, poor spirit, shortness of breath, weak positive of three-concave sign, thick breath sound of both lungs, audible moist and rale, phlegm and a little asthma. Chest CT: the double lung has thick texture, the local transmittance of the lung field is less uniform, the upper and middle lobes of the right lung and the left lung have higher density and higher density of strips and sheets, and the edge is fuzzy. Traditional Chinese medicine diagnosis: the traditional Chinese medicine granules prepared by the application are administered for 3 doses, 0.5 dose is taken every day, oral administration is carried out, the spasmodic suffocating cough is obviously relieved on the 3 rd day after the traditional Chinese medicine granules are taken, the traditional Chinese medicine granules can fall asleep stably at night, no fever and wheezing are caused, the traditional Chinese medicine granules are taken on the 6 th day after the traditional Chinese medicine granules are taken, occasional cough, little phlegm, basically no suffocating cough and no other discomfort are caused, and the traditional Chinese medicine granules are ordered to be taken continuously to consolidate the curative effect.

Case 2

The infant patient complains and is admitted to the hospital for 17 days 6 months 6 days later than 'repeated cough for 50 days, aggravation with cough and suffocation and fever for 2 days', and the symptoms are as follows: fever with a peak of 38.9 ℃, paroxysmal spasmodic cough with red eyes behind the cough, pronounced holding cough obviously at night and in the morning, phlegm in the throat, nasal obstruction and watery nasal discharge, poor dietary and sleep, loose stool, 2-4 times a day, and scanty urine. Physical examination: red tongue, white coating, purple fingerprint, poor spirit, weak positive of trisegion, thick breath sound of both lungs, audible humus and whitish and sputum whitish. Chest DR piece: the two lungs have much coarser texture. Traditional Chinese medicine diagnosis: the traditional Chinese medicine granules prepared by the application are given 4 doses of 0.3 dose each time, 2 times a day, orally taken, and taken 3 days after admission, cough and expectoration are relieved, so that the patient has no obvious cough suffocated, improved spirit, improved dietary and sleep conditions, no fever, and no cough, suffocated cough and other discomfort on the 6 th day after taking the medicine, and the patient is instructed to go on taking the medicine to consolidate the curative effect.

Case 3

The children patients take a certain of juba and girl, 5 years old for 5 months, take 'cough 10 more days' as a substitute for complaining to hospital, and have the following symptoms: cough, paroxysmal spasmodic cough, even red face and eyes, spitting sputum and food, is the most acute at 03:00 in the morning, can continue cough for about 30 minutes in severe cases, has no fever, is difficult to fall asleep at night, has normal stool and urine, and has no obvious improvement when antibiotics, antiallergic drugs and the like are used for treatment. Physical examination: red tongue, white coating, wiry and rapid pulse, poor spirit, pharyngeal congestion, slight shortness of breath, coarse breathing sound of both lungs, audible humus and whitish and sputum whitish. Traditional Chinese medicine diagnosis: the traditional Chinese medicine granules prepared by the application are given 7 doses, 1 dose is taken every day, the oral administration is carried out, the 4 th day of the medicine taking is carried out, the number of times of the attack of the suffocated cough is reduced, the duration is shortened, the vomiting is basically avoided, the patient can fall asleep stably at night, the 7 doses are taken, the cough is occasionally caused at night and in the morning, the suffocated cough is avoided, other discomfort is avoided, and the patient is advised to continue to take the medicine outside the hospital to consolidate the curative effect.

Case 4

The infant is admitted to hospital by paying attention to 'repeated cough for half a month' in 3 years old for 8 months after a certain child king, with the following symptoms: cough, paroxysmal spasmodic cough, red eyes and red eyes behind the cough, vomiting sputum and food, serious night attack, difficult sleep all night, wheezing, no fever, good diet, normal stool and urine, and 9 days of venous anti-infection treatment in a hospital, and no improvement of symptoms. Physical examination: red tongue, white coating, wiry and rapid pulse, poor spirit, pharyngeal congestion, slightly rapid respiration, coarse breathing sound of both lungs, audible humus, sputum and slight asthmatic sound. Perfecting blood routine: 40.08X 109/L of white blood cells, 11.63X 109/L of neutrophil count, 26.13X 109/L of lymphocyte count and less than 0.499mg/L of C-reactive protein; chest CT: the double lung has thick and abundant texture, the lung field has less uniform transmittance, the two lung leaves have higher density and blurred edges. Traditional Chinese medicine diagnosis: the traditional Chinese medicine granules prepared by the application are given for 10 doses, 1 dose is taken every day, the oral administration is carried out, the taking is carried out on the 5 th day, the spirit is improved, the suffocated cough is relieved earlier, the face red and the vomiting are basically avoided, the asthma is avoided, the 10 doses are taken, even cough and phlegm exist, other discomfort is avoided, and the blood is rechecked conventionally: 9.29X 109/L of leucocyte, 2.56X 109/L of neutrophilic granulocyte, 6.29X 109/L of lymphocyte and less than 0.2mg/L of C-reactive protein, and the patient is ordered to take medicine outside the hospital to consolidate the curative effect.

The foregoing is a preferred embodiment of the present invention, and it should be noted that it would be apparent to those skilled in the art that various modifications and enhancements can be made without departing from the principles of the invention, and such modifications and enhancements are also considered to be within the scope of the invention.

Claims

1. The traditional Chinese medicine composition for treating spasmodic cough is characterized by comprising the following components in parts by weight: 6-12 parts of radix bupleuri, 6-10 parts of radix paeoniae alba, 6-12 parts of fructus aurantii, 3-9 parts of liquorice, 10-15 parts of cortex mori radicis, 10-15 parts of cortex lycii radicis, 3-6 parts of rhizoma zingiberis, 6-10 parts of fructus schizandrae, 10-20 parts of rhizoma phragmitis, 6-10 parts of inula flower, 10-15 parts of bitter almond, 5-10 parts of ephedra, 6-10 parts of periostracum cicadae and 10-15 parts of stiff silkworm.

2. The traditional Chinese medicine composition for treating spasmodic cough according to claim 1, which is characterized by comprising the following components in parts by weight: 6 parts of radix bupleuri, 10 parts of radix paeoniae alba, 6 parts of fructus aurantii, 3 parts of liquorice, 10 parts of cortex mori radicis, 10 parts of cortex lycii radicis, 5 parts of rhizoma zingiberis, 6 parts of schisandra chinensis, 10 parts of rhizoma phragmitis, 6 parts of inula flower, 10 parts of bitter almond, 5 parts of ephedra, 6 parts of periostracum cicada and 10 parts of stiff silkworm.

3. The preparation method of the traditional Chinese medicine composition for treating spasmodic cough as claimed in claim 1 or 2, which comprises the following steps: weighing radix bupleuri, radix paeoniae alba, fructus aurantii, liquorice, cortex mori radicis, cortex lycii radicis, rhizoma zingiberis, fructus schizandrae, rhizoma phragmitis, inula flower, bitter apricot seed, ephedra, periostracum cicada and stiff silkworm according to parts by weight, soaking in water, decocting for 2 times, combining water decoctions, filtering, and collecting filtrate to obtain the traditional Chinese medicine composition.

4. The application of the traditional Chinese medicine composition for treating spasmodic cough according to claim 1 or 2 in preparing a traditional Chinese medicine preparation, wherein the traditional Chinese medicine preparation is prepared by adding conventional auxiliary materials into the active component of the traditional Chinese medicine composition.

5. The use of claim 4, wherein the Chinese medicinal preparation is decoction, oral liquid, tablet, capsule or granule;

6. The application of claim 5, wherein the Chinese medicinal preparation is a decoction, and is prepared by the following specific steps: weighing bupleurum, white paeony root, bitter orange, liquorice, white mulberry root-bark, cortex lycii radicis, dried ginger, schisandra chinensis, reed rhizome, inula flower, bitter apricot seed, ephedra herb, cicada slough and stiff silkworm according to the parts by weight, adding water which is 2-3cm higher than decoction pieces, soaking for 20-30 minutes, boiling with strong fire, decocting with slow fire for 20-30 minutes, decocting each medicine twice, extruding dregs after the second decoction, and obtaining 100-fold decoction liquid of 200 ml.

7. The use of claim 5, wherein the Chinese medicinal preparation is an oral liquid, and the preparation method comprises the following steps: weighing radix bupleuri, radix paeoniae alba, fructus aurantii, liquorice, cortex mori radicis, cortex lycii radicis, rhizoma zingiberis, fructus schizandrae, rhizoma phragmitis, inula japonica, bitter apricot seeds, ephedra, periostracum cicada and stiff silkworm in parts by weight, adding water for decocting twice, wherein the water addition amount is respectively 8 times and 6 times of the total weight of the medicinal materials, soaking for 0.5 hour, decocting for 1.5 hours and 1 hour respectively, combining the water decoctions for two times, filtering, concentrating the filtrate to a liquid medicine with the relative density of 1.05-1.08g/ml at 60 ℃, adding 0.5% of sodium benzoate, cooling, filtering, uniformly stirring, encapsulating and sterilizing to obtain the (without sucrose).

8. The use of claim 5, wherein the Chinese medicinal preparation is a tablet, and the specific preparation method comprises the following steps: weighing radix bupleuri, radix paeoniae alba, fructus aurantii, liquorice, cortex mori radicis, cortex lycii radicis, rhizoma zingiberis, fructus schizandrae, rhizoma phragmitis, inus inula flower, bitter apricot seed, ephedra, periostracum cicadae and stiff silkworm in parts by weight, adding water in an amount which is 8 times and 6 times of the total weight of the medicinal materials, soaking for 0.5 hour, respectively decocting for 1.5 hours and 1 hour, combining the water decoctions, filtering, concentrating the filtrate to thick medicinal paste with the relative density of 1.35-1.40g/ml at 60 ℃, vacuum drying at the temperature of below 80 ℃, crushing to 100 meshes, adding 10% of microcrystalline cellulose and 1% of starch slurry, granulating, drying at the temperature of 80 ℃, adding 3% of magnesium stearate and 3% of sodium carboxymethyl starch, uniformly mixing and pressing into tablets, and coating to obtain the Chinese medicinal composition.

9. The use of claim 5, wherein the Chinese medicinal preparation is a capsule, and the preparation method comprises: weighing radix bupleuri, radix paeoniae alba, fructus aurantii, liquorice, cortex mori radicis, cortex lycii radicis, rhizoma zingiberis, fructus schizandrae, rhizoma phragmitis, inula japonica, bitter apricot seeds, ephedra, periostracum cicada and stiff silkworm in parts by weight, adding water for decocting twice, wherein the water addition amount is respectively 8 times and 6 times of the total weight of the medicinal materials, soaking for 0.5 hour, decocting for 1.5 hours and 1 hour respectively, combining the water decoctions, filtering, concentrating the filtrate to thick ointment with the relative density of 1.35-1.40g/ml at 60 ℃, drying in vacuum at the temperature of below 80 ℃, crushing to 40 meshes, adding 5% of microcrystalline cellulose and 5% of talc magnesium, mixing uniformly, and filling into capsules.

10. The use of claim 5, wherein the Chinese medicinal preparation is a granule, and the preparation method comprises the following steps: weighing radix bupleuri, radix paeoniae alba, fructus aurantii, liquorice, cortex mori radicis, cortex lycii radicis, rhizoma zingiberis, schisandra chinensis, rhizoma phragmitis, inula flower, bitter apricot seed, ephedra herb, cicada slough and stiff silkworm according to parts by weight, adding water for decocting twice, wherein the water addition amount is 8 times and 6 times of the total weight of the medicinal materials respectively, soaking for 0.5 hour, decocting for 1.5 hours and 1 hour respectively, combining the water decoction of the two times, filtering, concentrating the filtrate to thick medicinal paste with the relative density of 1.35-1.40g/ml at 60 ℃, adding 20% of dextrin and 5% of stevioside, granulating by 12 meshes, drying at 80 ℃, finishing granules and subpackaging.