CN107456495A - It is a kind of be used to coughing, abundant expectoration, the composition granule and preparation method thereof of asthma - Google Patents
It is a kind of be used to coughing, abundant expectoration, the composition granule and preparation method thereof of asthma Download PDFInfo
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- CN107456495A CN107456495A CN201710692316.5A CN201710692316A CN107456495A CN 107456495 A CN107456495 A CN 107456495A CN 201710692316 A CN201710692316 A CN 201710692316A CN 107456495 A CN107456495 A CN 107456495A
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- abundant expectoration
- asthma
- cough
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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- A61K2236/50—Methods involving additional extraction steps
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- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses it is a kind of be used to coughing, abundant expectoration, asthma composition granule and preparation method thereof.Said composition granule includes the raw material of following parts by weight：90 110 parts of Exocarpium Citri Rubrum, 70 90 parts of almond, 40 60 parts of mulberry leaf, 40 60 parts of balloonflower root, 40 60 parts of orange peel, 20 40 parts of Poria cocos, 20 40 parts of perilla seed, 10 30 parts of radix glycyrrhizae, 50 60 parts of excipient, 15 25 parts of binder, 10 12 parts of lubricant, 58 parts of preservative.Said composition granule be by extracting, concentrating, pelletizing, it is prepared by whole grain, drying and other steps.Said composition granule is applied to cough, abundant expectoration caused by cold and chill, asthma, has and absorbs the features such as fast, effect is rapid, easy to carry, suitable for people of all ages.
Description
Technical field
The invention belongs to biomedicine field, is related to a kind of composition granule and preparation method thereof, more particularly to one
Kind it is used to coughing, abundant expectoration, the composition granule and preparation method thereof of asthma.
Background technology
Cough, phlegm, asthma are the common main signs of ALRI.When respiratory tract is inflamed lesion, respiratory tract fluid
Composition will change, and form sputum.It is de- comprising mucus, foreign matter, pathogenic microorganism, various inflammatory cells and necrosis in sputum
The compositions such as the mucomembranous epithelial cell fallen.Phlegm is divided into cold phlegm, wind phlegm, hot phlegm, damp phlegm and sticky sputum etc. by the traditional Chinese medical science, and the reason for forming phlegm has
A lot, first, have a delicate constitution, the deficiency of qi in middle-jiao, due to spleen insufficiency, water-damp retention can be made, condensed for phlegm；Second, taste are thin
Weak, place is stagnant to be stayed, impairing the spleen and stomach；Or comfortable food is eaten raw, melon and fruit, middle-jiao yang, function of the spleen and stomach is hindered；Or because of pyreticosis hyperposia, spleen fortune not as good as etc. all
Water-damp retention can be made, be collected as phlegm.Also addiction to greasy and sweet foods, foul smell is hot and suffocating in stomach, and making humidogene heat, can also to turn to phlegm turbid；The
Three, diseases caused by external factors are lost and controlled, or it is weak suffer from diseases caused by external factors repeatly, lung qi is hindered, it is impossible to the defeated cloth of Tianjin four, defeated bladder under regulating fluid apssage, stop aqueous,
Also can be into phlegm, phlegm stores in lung, unsmoothness of pulmonary qi, and phlegm gushes air flue and sent out, and must cause coughing with a lot of sputum.Chill attacks body, the lighter's beam table, card
Wait aversion to cold weight, heating is light, lossless, low voice speaking or rhiocnesmus sneeze of having a stuffy nose, when flow clear tears, pharynx itches, coughs, the thin color of expectoration is white, pale tongue
Red thin white fur of tongue and moisten, floating pulse or floating tight.Severe one attacks lung, it is seen that cough, pharynx are itched, had a stuffy nose, runny nose, sneezing more, and foul wind, expectoration color are white
Matter is dilute, and pink tongue tongue is white, floating pulse or the symptom such as floating tight.The visible sticky color of coughing with a lot of sputum of chill criminal's lung is white, dyspnea and fullness in the chest, with phlegm wet
Accumulate based on lung.
At present, various with relieving cough and reducing sputum, effect of relievining asthma drug variety, formulation is based on oral formulations, including syrup
Agent, tablet, oral liquid, pill etc..Most patients select syrup, and it is suitable to be primarily due to its mouthfeel, but in syrup
Containing substantial amounts of sugar, prepare and storage in easily microbial contamination, cause syrup it is mould lose it is rotten.Although tablet is stable
Property is strong compared with syrup, but be not easy to swallow there is also child and coma patient, tabletting when the auxiliary material that adds influence medicine sometimes
The shortcomings of dissolution and bioavilability.Oral liquid can cause bioavilability low due to first pass effect be present, and pill can also be present
The shortcomings that taking inconvenience.Abundant expectoration patient is related to each age level caused by chill, it is therefore necessary to prepares good effect, convenient to take
Be used to treat the medicines of the respiratory tract infection such as abundant expectoration caused by chill, asthma to meet the needs of each age level patient.
Chinese medicine is the distinctive traditional Chinese medical theory in China and the product of practice, and aboundresources is with a long history, is that the mankind earliest should
Natural organic substance, it has the advantage of small toxic side effect, good effect and persistent in terms of disease is treated.
Exocarpium Citri Rubrum is rutaceae orange Citrus reticulata Blanco and its drying outside rind of variety.
Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is pungent, bitter, temperature.Return lung, the spleen channel.【Function is with curing mainly】Regulating the flow of QI to ease the stomach,
It is eliminating dampness and eliminating phlegm.For coughing with a lot of sputum, dyspepsia is got sick from drinking too much wine, and evil of vomitting ruffian is vexed.
Almond be rosaceous plant ansu apricot Armeniaca vulgaris Lam.var.ansu (Maxim.) Yu et Lu.,
Siberia apricot Armeniaca sibirica (L.) Lam., prunus mandshuricaKoehne Armeniaca mandshurica (Maxim.) Skv.
Or apricot Armeniaca vulgaris Lam. dry mature seed.Record in《Dictionary of medicinal plant》：【Nature and flavor and channel tropism】Hardship,
Temperature, it is poisonous.Enter lung, large intestine channel.【Function is with curing mainly】Expelling phlegm and arresting coughing, relieving asthma, ease constipation.Exogenous cough is controlled, asthma is full, larynx numbness, intestinal dryness
Constipation.
Mulberry leaf are moraceae plants mulberry Morus alba L. dried leaf.Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor
With channel tropism】It is sweet, bitter, tremble with fear.Return lung, Liver Channel.【Function is with curing mainly】Dispelling wind and heat from the body, clearing away the lungheat and moisturizing, clear liver and improve vision.For wind-heat sense
Emit, lung-heat type cough, dizziness headache, hot eyes is dim-sighted.
Balloonflower root is Campanulaceae balloonflower root Platycodon, grandiflorum (Jacq.) A.DC. dry root.Record
In《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is bitter, pungent, put down.Return lung, warp.【Function is with curing mainly】Facilitaing lung, relieving sore-throat, eliminating the phlegm,
Apocenosis.For coughing with a lot of sputum, uncomfortable in chest not smooth, pharyngalgia sound is mute, lung carbuncle pyemesis.
Orange peel is the pericarp of a variety of tangerine classes such as rutaceae tangerine produced in fujian province or Zhu's tangerine.Record in《Dictionary of medicinal plant》：【Nature and flavor with
Channel tropism】It is pungent, bitter, temperature.Enter spleen, lung channel.【Function is with curing mainly】Qi-regulating, in tune, eliminating dampness, resolving sputum.Control fullness and oppression of chest and abdomen, do not feel like eating,
Vomit hiccup, coughing with a lot of sputum.
Poria cocos is On Polyporaceae Poria cocos Poriacocos (Schw.) Wolf dry sclerotia.Record in《Middle traditional Chinese medicines
Allusion quotation》Version in 2015：【Nature and flavor and channel tropism】It is sweet, light, put down.The thoughts of returning home, lung, spleen, kidney channel.【Function is with curing mainly】Clearing damp and promoting diuresis, invigorating the spleen, rather
The heart.For oedema oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
Perilla seed is labiate purple perilla Perilla/rwiescem'(L.) Britt. dry mature fruit.Record
In《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is pungent, temperature.Return lung passes through.【Function is with curing mainly】Lowering the adverse-rising QI to resolve phlegm, it is relieving cough and asthma,
Relax bowel.For phlegm stops up the circulation of vital energy in the wrong direction, cough and asthma, dry constipation of intestines.
Radix glycyrrhizae is glycyrrhizic legume GZwr/ikauralensis Fisch., swollen fruit Radix Glycyrrhiza
Inflata Bat. or glycyrrhiza glabra Glycyrrhizaglabra L. dry root and rhizome.Record in《Chinese Pharmacopoeia》2015
Year version：【Nature and flavor and channel tropism】It is sweet, put down.The thoughts of returning home, lung, spleen, stomach.【Function is with curing mainly】Invigorate the spleen and benefit qi , Cheongju thermal detoxifications, eliminating the phlegm stops
Cough, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction are suddenly ached
Bitterly, carbuncle sore tumefacting virus, drug toxicity, strong is alleviated.
The disclosure of background above technology contents is only used for inventive concept and the technical scheme that auxiliary understands the present invention, and it is not
The prior art of present patent application is necessarily belonged to, shows the applying date of the above in present patent application in no tangible proof
In the case of disclosed, above-mentioned background technology should not be taken to evaluate the novelty and creativeness of the application.
The content of the invention
It is an object of the invention to provide it is a kind of be used to coughing, abundant expectoration, asthma composition granule and preparation method thereof,
With solve existing for prior art treat cough, abundant expectoration, asthma drug bioavailability it is low, mouthfeel is bad, take carry not
Just the problems such as.Said composition process for producing granula is simple to operation, cost of material is low, and with absorbing, fast, effect is rapid, takes
And the advantages that easy to carry, mouthfeel is good, suitable for people of all ages.
To solve the above problems, the present invention takes following technical scheme：
It is a kind of be used to coughing, abundant expectoration, the composition granule of asthma, include the raw materials of following parts by weight：Exocarpium Citri Rubrum 90-110
Part, almond 70-90 parts, mulberry leaf 40-60 parts, balloonflower root 40-60 parts, orange peel 40-60 parts, Poria cocos 20-40 parts, perilla seed 20-40 parts,
Radix glycyrrhizae 10-30 parts, excipient 50-60 parts, binder 15-25 parts, lubricant 10-12 parts, preservative 5-8 parts.
Excipient described above is at least one of Icing Sugar, lactose, cyclodextrin；The binder is starch slurry, carboxylic first
At least one of base sodium cellulosate, carboxylic propyl methocel；The lubricant is magnesium stearate or talcum powder；The anti-corrosion
Agent is at least one of benzoic acid, sorbic acid, potassium sorbate.
It is described above be used for cough, abundant expectoration, asthma composition granule, prepare be used for cough, abundant expectoration, asthma group
Purposes in polymer beads agent.
Described in more than one be used to cough, abundant expectoration, asthma composition granule preparation method, including following step
Suddenly：
S1：Raw material is weighed by following parts by weight：Exocarpium Citri Rubrum 90-110 parts, almond 70-90 parts, mulberry leaf 40-60 parts, balloonflower root 40-
60 parts, orange peel 40-60 parts, Poria cocos 20-40 parts, perilla seed 20-40 parts, radix glycyrrhizae 10-30 parts, excipient 50-60 parts, binder
15-25 parts, lubricant 10-12 parts, preservative 5-8 parts；
S2：The raw material for taking step S1 to weigh is fitted into extractor, adds water to cook twice, and filtration, supernatant concentration is into thick paste；
S3：Take thick paste made from step S2 to add excipient, binder, lubricant, preservative mixing, stir；
S4：Step S3 thick paste is placed in granulator single-size is made；
S5：Particle made of step S4 is placed in baking box and dried；
S6：The dried particle coolings of step S5 are treated, sieving, produce the composition granule.
Further, step S2 is for the first time plus 1.5-2h is boiled in the 10-15 times of decocting measured, second plus the 8-10 times of decocting measured
1-1.5h is boiled, is concentrated into relative density in the thick paste that 65 DEG C are 1.03-1.07；Drying temperature is 60-80 DEG C in step S5, is dried
It is less than 2% to particle water content；The dried particles of step S6 first cross 10 mesh sieves and screen out big particle, are screened out carefully after 80 mesh sieves
Powder.
Compared with prior art, the present invention possesses following beneficial effect：
1. the composition granule of the present invention can effectively alleviate cough, abundant expectoration, asthma, total effective rate is up to 94.3%.
2. the present invention had both maintained the characteristics of decoction effect is rapid, decoction is overcome again and faces the shortcomings that used time decoction is inconvenient；
And delicious taste, small volume, take, store and transport and be more convenient.
3. raw material of the present invention is pure Chinese medicine medicine materical crude slice, it is easy to get safely, has no toxic side effect, preparation method is simple to operation.
Embodiment
With reference to specific embodiment, the invention will be further described, but does not limit the scope of the invention and apply
Scope：
First, for coughing, abundant expectoration, asthma composition granule preparation
It is a kind of be used for cough, abundant expectoration, asthma composition granule preparation method, comprise the following steps：
S1：Raw material is weighed by following parts by weight：Exocarpium Citri Rubrum 90-110 parts, almond 70-90 parts, mulberry leaf 40-60 parts, balloonflower root 40-
60 parts, orange peel 40-60 parts, Poria cocos 20-40 parts, perilla seed 20-40 parts, radix glycyrrhizae 10-30 parts, excipient 50-60 parts, binder
15-25 parts, lubricant 10-12 parts, preservative 5-8 parts；
The excipient is at least one of Icing Sugar, lactose, cyclodextrin；
The binder is at least one of starch slurry, sodium carboxymethylcellulose, carboxylic propyl methocel；
The lubricant is magnesium stearate or talcum powder；
The preservative is at least one of benzoic acid, sorbic acid, potassium sorbate；
S2：The raw material for taking step S1 to weigh is fitted into extractor, adds the 10-15 times of decocting measured to boil 1.5-2h, filtering, the dregs of a decoction
Add the 8-10 times of decocting measured to boil 1-1.5h, filter, merging filtrate, filtrate is concentrated into relative density at 65 DEG C as 1.03-1.07's
Thick paste；
S3：Take thick paste made from step S2 to add excipient, binder, lubricant, preservative mixing, stir；
S4：Step S3 thick paste is placed in granulator single-size is made；
S5：Particle made of step S4 is placed in baking box and dried, design temperature is 60-80 DEG C, and drying is aqueous to particle
Amount is less than 2%；
S6：The dried particle coolings of step S5 are treated, 10 mesh sieves is first crossed and screens out big particle, screened out carefully after 80 mesh sieves
Powder, remaining particle are the composition granule.
Embodiment 1
It is a kind of be used for cough, abundant expectoration, asthma composition granule preparation method, comprise the following steps：
S1：Raw material is weighed by following parts by weight：90 parts of Exocarpium Citri Rubrum, 70 parts of almond, 40 parts of mulberry leaf, 40 parts of balloonflower root, 40 parts of orange peel,
20 parts of Poria cocos, 20 parts of perilla seed, 10 parts of radix glycyrrhizae, 50 parts of excipient, 15 parts of binder, 10 parts of lubricant, 5 parts of preservative；
The excipient is Icing Sugar；
The binder is starch slurry；
The lubricant is magnesium stearate；
The preservative is benzoic acid；
S2：The raw material for taking step S1 to weigh is fitted into extractor, adds the decocting of 10 times of amounts to boil 1.5h, filters, and the dregs of a decoction add 8 times
1h is boiled in the decocting of amount, filtering, merging filtrate, and filtrate is concentrated into relative density in the thick paste that 65 DEG C are 1.03；
S3：Take thick paste made from step S2 to add excipient, binder, lubricant, preservative mixing, stir；
S4：Step S3 thick paste is placed in granulator single-size is made；
S5：Particle made of step S4 is placed in baking box and dried, design temperature is 60 DEG C, and drying is low to particle water content
In 2%；
S6：The dried particle coolings of step S5 are treated, 10 mesh sieves is first crossed and screens out big particle, screened out carefully after 80 mesh sieves
Powder, remaining particle are the composition granule.
Embodiment 2
It is a kind of be used for cough, abundant expectoration, asthma composition granule preparation method, comprise the following steps：
S1：Raw material is weighed by following parts by weight：95 parts of Exocarpium Citri Rubrum, 75 parts of almond, 45 parts of mulberry leaf, 45 parts of balloonflower root, 45 parts of orange peel,
25 parts of Poria cocos, 25 parts of perilla seed, 15 parts of radix glycyrrhizae, 52 parts of excipient, 18 parts of binder, 11 parts of lubricant, 6 parts of preservative；
The excipient is lactose；
The binder is sodium carboxymethylcellulose；
The lubricant is talcum powder；
The preservative is sorbic acid；
S2：The raw material for taking step S1 to weigh is fitted into extractor, adds the decocting of 11 times of amounts to boil 2h, filters, and the dregs of a decoction add 9 times of amounts
Decocting boil 1.5h, filter, merging filtrate, filtrate be concentrated into relative density 65 DEG C be 1.04 thick paste；
S3：Take thick paste made from step S2 to add excipient, binder, lubricant, preservative mixing, stir；
S4：Step S3 thick paste is placed in granulator single-size is made；
S5：Particle made of step S4 is placed in baking box and dried, design temperature is 65 DEG C, and drying is low to particle water content
In 2%；
S6：The dried particle coolings of step S5 are treated, 10 mesh sieves is first crossed and screens out big particle, screened out carefully after 80 mesh sieves
Powder, remaining particle are the composition granule.
Embodiment 3
It is a kind of be used for cough, abundant expectoration, asthma composition granule preparation method, comprise the following steps：
S1：Raw material is weighed by following parts by weight：100 parts of Exocarpium Citri Rubrum, 80 parts of almond, 50 parts of mulberry leaf, 50 parts of balloonflower root, orange peel 50
Part, 30 parts of Poria cocos, 30 parts of perilla seed, 20 parts of radix glycyrrhizae, 55 parts of excipient, 20 parts of binder, 11 parts of lubricant, 7 parts of preservative；
The excipient is cyclodextrin；
The binder is carboxylic propyl methocel；
The lubricant is magnesium stearate；
The preservative is potassium sorbate；
S2：The raw material for taking step S1 to weigh is fitted into extractor, adds the decocting of 12 times of amounts to boil 1.8h, filters, and the dregs of a decoction add 10
1.2h is boiled in the decocting of amount again, is filtered, merging filtrate, and filtrate is concentrated into relative density in the thick paste that 65 DEG C are 1.05；
S3：Take thick paste made from step S2 to add excipient, binder, lubricant, preservative mixing, stir；
S4：Step S3 thick paste is placed in granulator single-size is made；
S5：Particle made of step S4 is placed in baking box and dried, design temperature is 70 DEG C, and drying is low to particle water content
In 2%；
S6：The dried particle coolings of step S5 are treated, 10 mesh sieves is first crossed and screens out big particle, screened out carefully after 80 mesh sieves
Powder, remaining particle are the composition granule.
Embodiment 4
It is a kind of be used for cough, abundant expectoration, asthma composition granule preparation method, comprise the following steps：
S1：Raw material is weighed by following parts by weight：105 parts of Exocarpium Citri Rubrum, 85 parts of almond, 55 parts of mulberry leaf, 55 parts of balloonflower root, orange peel 55
Part, 35 parts of Poria cocos, 35 parts of perilla seed, 25 parts of radix glycyrrhizae, 58 parts of excipient, 22 parts of binder, 11 parts of lubricant, 7 parts of preservative；
The excipient is Icing Sugar and lactose, wherein 38 parts of Icing Sugar, 20 parts of milk powder；
The binder is sodium carboxymethylcellulose and carboxylic propyl methocel, wherein 10 parts of sodium carboxymethylcellulose,
12 parts of carboxylic propyl methocel；
The lubricant is talcum powder；
The preservative is sorbic acid and potassium sorbate, wherein 3 parts of sorbic acid, 4 parts of potassium sorbate；
S2：The raw material for taking step S1 to weigh is fitted into extractor, adds the decocting of 13 times of amounts to boil 2h, filters, and the dregs of a decoction add 10 times
1.5h is boiled in the decocting of amount, filtering, merging filtrate, and filtrate is concentrated into relative density in the thick paste that 65 DEG C are 1.06；
S3：Take thick paste made from step S2 to add excipient, binder, lubricant, preservative mixing, stir；
S4：Step S3 thick paste is placed in granulator single-size is made；
S5：Particle made of step S4 is placed in baking box and dried, design temperature is 75 DEG C, and drying is low to particle water content
In 2%；
S6：The dried particle coolings of step S5 are treated, 10 mesh sieves is first crossed and screens out big particle, screened out carefully after 80 mesh sieves
Powder, remaining particle are the composition granule.
Embodiment 5
It is a kind of be used for cough, abundant expectoration, asthma composition granule preparation method, comprise the following steps：
S1：Raw material is weighed by following parts by weight：110 parts of Exocarpium Citri Rubrum, 90 parts of almond, 60 parts of mulberry leaf, 60 parts of balloonflower root, orange peel 60
Part, 40 parts of Poria cocos, 40 parts of perilla seed, 30 parts of radix glycyrrhizae, 60 parts of excipient, 25 parts of binder, 12 parts of lubricant, 8 parts of preservative；
The excipient is Icing Sugar, lactose, wherein cyclodextrin, each 20 parts of Icing Sugar, lactose, cyclodextrin；
The binder is starch slurry, sodium carboxymethylcellulose, wherein carboxylic propyl methocel, 10 parts of starch slurry, carboxylic
7 parts of sodium carboxymethylcellulose pyce, 8 parts of carboxylic propyl methocel；
The lubricant is talcum powder；
The preservative is benzoic acid, sorbic acid, wherein potassium sorbate, 2 parts of benzoic acid, 3 parts of sorbic acid, potassium sorbate 3
Part；
S2：The raw material for taking step S1 to weigh is fitted into extractor, adds the decocting of 15 times of amounts to boil 2h, filters, and the dregs of a decoction add 10 times
1.5h is boiled in the decocting of amount, filtering, merging filtrate, and filtrate is concentrated into relative density in the thick paste that 65 DEG C are 1.07；
S3：Take thick paste made from step S2 to add excipient, binder, lubricant, preservative mixing, stir；
S4：Step S3 thick paste is placed in granulator single-size is made；
S5：Particle made of step S4 is placed in baking box and dried, design temperature is 80 DEG C, and drying is low to particle water content
In 2%；
S6：The dried particle coolings of step S5 are treated, 10 mesh sieves is first crossed and screens out big particle, screened out carefully after 80 mesh sieves
Powder, remaining particle are the composition granule.
2nd, melting is tested
Example 1-5 samples 10g is placed in beaker respectively, and the sample of each embodiment is respectively placed in two beakers,
Each beaker 5g, then water and 70-80 DEG C of hot water that 20 times of amount temperatures are 23-26 DEG C are separately added into, stir 5min；It is cooled to
Room temperature, the regular hour is stood, range estimation comparison is carried out, the results are shown in Table 1.
The melting result of the test table of table 1
Result of the test shows：1-5 of embodiment of the present invention granule melting is good.
3rd, clinical test
1. case selection
The patient of selection abundant expectoration, the symptom such as itch with larynx, cough, pant.
2. medication
Test group：The sample of the embodiment of the present invention 3 is taken, 3 times a day, aftermeals, 2 days courses for the treatment of.
Control group：Certain commercially available brand preventing phlegm from forming and stopping coughing syrup is taken, 3 times a day, aftermeals, 2 days courses for the treatment of.
3. efficacy determination
Carry out comprehensive descision point recovery from illness, effective, improvement, invalid 4 grades of standard determinations.
1. fully recover：Without phlegm, cough larynx is itched symptom disappearance, and asthma symptom disappears.
It is 2. effective：Amount of expectoration is reduced or without phlegm, and cough larynx is itched symptom mitigation or disappearance, and asthma symptom mitigates or disappeared.
3. take a turn for the better：Amount of expectoration is reduced, and cough larynx is itched symptom mitigation, and asthma symptom mitigates.
It is 4. invalid：Amount of expectoration it is constant or increase, cough larynx itch symptom it is constant or aggravate, asthma symptom it is constant or aggravate.
4. result of the test
The treatment of 50 test group 70, control group patients Jing Guo a course for the treatment of, the results detailed in Table 2.
Test group：Recovery from illness：31.4%, it is effective：37.2%, take a turn for the better：25.7%, it is invalid：5.7%, total effective 94.3%.
The clinical application effect table of table 2
As a result show：Using the sample of the embodiment of the present invention 3, itch available for abundant expectoration caused by chill, with larynx, cough,
The treatment of asthma etc., safe to use, effective, effective percentage up to 94.3%, it can obviously improve abundant expectoration, the disease such as larynx is itched, is coughed, is panted
Shape, experiment process is without allergy and adverse reaction.Test group cure rate and obvious effective rate are above control group.
It is several typical examples below：
Exemplary 1
Zhao, man, 36 years old.Brought up phlegm when one coughs after being affected by the cold, swallow itch, have a stuffy nose, expectoration color white matter it is dilute, pink tongue tongue is white, arteries and veins
It is floating.Take the product of the embodiment of the present invention 2 two days later, above-mentioned symptom disappears, and is discontinued 7 days and has no repeatedly.
Exemplary 2
Lin, female, 46 years old.Brought up phlegm when one coughs after being affected by the cold, expectoration color white matter it is dilute, itch with larynx, pant, pink tongue tongue
In vain, floating and tense pulse.Take the product of the embodiment of the present invention 4 two days later, above-mentioned symptom disappears, and is discontinued 7 days and has no repeatedly.
Exemplary 3
Lee, man 33 years old.After catching cold, nasal obstruction, sneeze, the sticky color of foul wind, coughing with a lot of sputum is white, dyspnea and fullness in the chest more.Take
Two days later, above-mentioned symptom disappears the product of the embodiment of the present invention 5, is discontinued 7 days and has no repeatedly.
The specific implementation of the invention is not to be limited to these illustrations for above content, is led for technology belonging to the present invention
For the those of ordinary skill in domain, without departing from the inventive concept of the premise, some simple deduction or replace can also be made,
The scope of patent protection that the present invention is determined by the claims submitted should be all considered as belonging to.
Claims (10)
1. it is a kind of be used for cough, abundant expectoration, asthma composition granule, it is characterised in that include the raw material of following parts by weight：Tangerine
Red 90-110 parts, almond 70-90 parts, mulberry leaf 40-60 parts, balloonflower root 40-60 parts, orange peel 40-60 parts, Poria cocos 20-40 parts, perilla seed
20-40 parts, radix glycyrrhizae 10-30 parts, excipient 50-60 parts, binder 15-25 parts, lubricant 10-12 parts, preservative 5-8 parts.
2. it is according to claim 1 be used for cough, abundant expectoration, asthma composition granule, it is characterised in that the figuration
Agent is at least one of Icing Sugar, lactose, cyclodextrin.
3. it is according to claim 1 be used for cough, abundant expectoration, asthma composition granule, it is characterised in that the bonding
Agent is at least one of starch slurry, sodium carboxymethylcellulose, carboxylic propyl methocel.
4. it is according to claim 1 be used for cough, abundant expectoration, asthma composition granule, it is characterised in that the lubrication
Agent is magnesium stearate or talcum powder.
5. it is according to claim 1 be used for cough, abundant expectoration, asthma composition granule, it is characterised in that the anti-corrosion
Agent is at least one of benzoic acid, sorbic acid, potassium sorbate.
6. it is a kind of according to claim any one of 1-5 be used for cough, abundant expectoration, asthma composition granule preparation side
Method, it is characterised in that comprise the following steps：
S1：Raw material is weighed by following parts by weight：Exocarpium Citri Rubrum 90-110 parts, almond 70-90 parts, mulberry leaf 40-60 parts, balloonflower root 40-60 parts,
Orange peel 40-60 parts, Poria cocos 20-40 parts, perilla seed 20-40 parts, radix glycyrrhizae 10-30 parts, excipient 50-60 parts, binder 15-25
Part, lubricant 10-12 parts, preservative 5-8 parts；
S2：The raw material for taking step S1 to weigh is fitted into extractor, adds water to cook twice, and filtration, supernatant concentration is into thick paste；
S3：Take thick paste made from step S2 to add excipient, binder, lubricant, preservative mixing, stir；
S4：Step S3 thick paste is placed in granulator single-size is made；
S5：Particle made of step S4 is placed in baking box and dried；
S6：The dried particle coolings of step S5 are treated, sieving, produce the composition granule.
7. it is according to claim 6 be used to coughing, abundant expectoration, asthma composition granule preparation method, its feature exists
In step S2 is for the first time plus 1.5-2h is boiled in the 10-15 times of decocting measured, and for the second time plus 1-1.5h is boiled in the 8-10 times of decocting measured, and is concentrated
To relative density in the thick paste that 65 DEG C are 1.03-1.07.
8. it is according to claim 6 be used to coughing, abundant expectoration, asthma composition granule preparation method, its feature exists
In drying temperature is 60-80 DEG C in step S5, dries to particle water content and is less than 2%.
9. it is according to claim 6 be used to coughing, abundant expectoration, asthma composition granule preparation method, its feature exists
In the dried particles of step S6 first cross 10 mesh sieves and screen out big particle, and fine powder is screened out after 80 mesh sieves.
10. it is according to claim 1 be used for cough, abundant expectoration, asthma composition granule, it is characterised in that preparing
For coughing, abundant expectoration, asthma composition granule in purposes.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710692316.5A CN107456495A (en) | 2017-08-14 | 2017-08-14 | It is a kind of be used to coughing, abundant expectoration, the composition granule and preparation method thereof of asthma |
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| CN201710692316.5A CN107456495A (en) | 2017-08-14 | 2017-08-14 | It is a kind of be used to coughing, abundant expectoration, the composition granule and preparation method thereof of asthma |
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| CN201710692316.5A Pending CN107456495A (en) | 2017-08-14 | 2017-08-14 | It is a kind of be used to coughing, abundant expectoration, the composition granule and preparation method thereof of asthma |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042683A (en) * | 2018-01-10 | 2018-05-18 | 凯瑞欧（天津）生物技术有限公司 | A kind of integration of drinking and medicinal herbs product of anti-haze clearing lung-heat |
| CN110787277A (en) * | 2019-11-18 | 2020-02-14 | 类红缨 | Lung moistening and cough relieving edible particle and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102430048A (en) * | 2011-12-28 | 2012-05-02 | 成都拜特尔药业有限公司 | Chinese medicinal composition for treating cough and preparation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102430048A (en) * | 2011-12-28 | 2012-05-02 | 成都拜特尔药业有限公司 | Chinese medicinal composition for treating cough and preparation method thereof |
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| 孙建民等: "二陈汤加味治疗小儿迁延性肺炎200例", 《中国医药导报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042683A (en) * | 2018-01-10 | 2018-05-18 | 凯瑞欧（天津）生物技术有限公司 | A kind of integration of drinking and medicinal herbs product of anti-haze clearing lung-heat |
| CN110787277A (en) * | 2019-11-18 | 2020-02-14 | 类红缨 | Lung moistening and cough relieving edible particle and preparation method thereof |
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Application publication date: 20171212 |