CN1814123B - Chinese medicine composition for treating diabetes and its preparation method - Google Patents
Chinese medicine composition for treating diabetes and its preparation method Download PDFInfo
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- CN1814123B CN1814123B CN 200510061808 CN200510061808A CN1814123B CN 1814123 B CN1814123 B CN 1814123B CN 200510061808 CN200510061808 CN 200510061808 CN 200510061808 A CN200510061808 A CN 200510061808A CN 1814123 B CN1814123 B CN 1814123B
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Abstract
The invention discloses a medicinal combination for curing diabetes and its application, characterized by that it is composed of American Ginseng leaf, Dongguapi, Common Anemarrhena Rhizome, Danshen, Rehmannia Root, Common Yam Rhizome, etc, and its preparing method includes the following steps of: washing these drugs, grinding them into rough powders, decocting with water twice, 2 hours for the first time and 1 hour for the second time, filtering, concentrating the filtrate into ointment, drying and crushing the ointment and passing through 100-mesh sieve, mixing uniformly, wetting, softening, forming into a mass and taking out the mass, and making the mass into granules. It is a purely natural medicinal preparation, having functions of nourishing Yin and reducing fire and clearing heat and removing damp as well as strengthening the body resistance and eliminating evil and remarkable curative effect on various diabetes; it is to be orally taken, tasting good, and easy to be accepted by patients; has characters of obviously improving clinical symptoms in use, high curative effect, short period of treatment, low price, and no allergic reaction or toxicity and side effect; able to save the curing expenses by above 62%; and it is an ideal pure Chinese medicinal preparation for curing diabetes at present.
Description
Technical field
The present invention relates to technical field of Chinese patent medicine, is a kind of Chinese medicine composition for the treatment of diabetes and preparation method thereof
Background technology
Diabetes are a kind of commonly encountered diseases, frequently-occurring disease.The feature of diabetics is eat many, drink many, drain many, human body and become thin the three-many-one-little that promptly it has often been said.Diabetes spp motherland medical science diabetes category is that a kind of course of disease is long, pathological change complexity, the lifelong property disease that the more chronic progressive external of complication increases the weight of.Its pathological changes is not only involved the heart, brain, liver, board and to the muscle arteries and veins of whole body, skeleton, skin, muscle etc. after lung, stomach, kidney development.A large amount of Diabetes Epidemiological Investigation results show that generally the prevalence of China's diabetes is rising year by year, and the age of onset of non-insulin-dependent diabetes mellitus has the trend of rejuvenation day by day.Although the present distribution of diabetes absolute value of China still is in reduced levels with respect to tumor, cardiovascular and cerebrovascular disease, its rate of climb and trend obviously surpass above-mentioned disease.China has 3,000 ten thousand diabetes patients now, and medical expense is about 9000 yuan per capita, China one be only be used for diabetes medical expense up to 27,000,000,000 RMB.Scholarly forecast to 2025 a year Chinese diabetes patient will reach 5,000 ten thousand in the Asia-Pacific diabetes meeting of IDF in 1999.
Current, to the treatment of this disease with and the control of complication, be that modern medicine is quite felt stubborn problem.Treatment of diabetes is mostly based on doctor trained in Western medicine now, and the western medical treatment diabetes are used medicines such as sulphanylureas, biguanides and insulin mostly, though its hypoglycemic activity is obvious, can reach the degree of regulating metabolism disorder, but relapse rate is higher. it is more complication to occur, and takes for a long time, and certain side effect is arranged.The sulfonylureas drugs for diabetes thing can cause hypoglycemia, digestive tract reaction, anaphylaxis, hemopoietic system and neural infringement etc., biguanides can cause digestive tract reaction, lactic acidosis, anaphylaxis etc., glucosidase inhibitor can cause gastrointestinal reaction, hypoglycemia, anaphylaxis etc., the hepatic injury of euglycemic agent is forbidden or the like by US and European because of causing serious hepatic injury as troglitazone.This class medicine all focuses on adjusts the intravital insulin of patient, can not carry out the integral body conditioning to the patient body body, thereby therapeutic effect is undesirable; The price of this type of medicine is than higher in addition, and the patient bears difficulty.
Summary of the invention
In order to address the above problem, purpose of the present invention and aim are exactly the medicine that a kind of ideal treatment diabetes finally are provided for society by meticulous development of process and long-term clinical application, this medicine is based on adjustment patient body function, thereby improves patient's self allomeric function.Utilize this drug treatment of diabetic, particularly the thin patient as bavin of diabetes later stage body had specially good effect, medication can regain one's strength a course of treatment, take for a long time and can make the basic rehabilitation of health, period in a medicine can be kept on a diet, and medicine economy, material benefit, curative effect determines, without any side effects, be the pure Chinese medicine medicine of current a kind of ideal treatment diabetes.
The present invention is according to understanding and the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs principle of the traditional Chinese medical science to diabetes (diabete), according to traditional Chinese medical science prescription and preparation principle Chinese medicine composition is developed meticulously, realizes by following technical scheme:
The raw material that medicine of the present invention comes from plant is Folium Panacis Quinquefolii, Exocarpium Benincasae, Radix Salviae Miltiorrhizae, the Rhizoma Anemarrhenae, Rhizoma Dioscoreae etc., the consumption of its component is groped to sum up to draw through the inventor in a large number, each amounts of components all has curative effect preferably in following ranges, and medicine of the present invention contains
166～498 parts of 331～999 portions of Rhizoma Dioscoreaes of 331～999 parts of Exocarpium Benincasaes of Folium Panacis Quinquefolii
110～330 parts of 166～498 portions of Radix Rehmanniae of 166～498 parts of Rhizoma Anemarrhenaes of Radix Salviae Miltiorrhizae
Preferable range is:
248～496 parts of 498～998 portions of Rhizoma Dioscoreaes of 498～998 parts of Exocarpium Benincasaes of Folium Panacis Quinquefolii
165～275 parts of 248～496 portions of Radix Rehmanniae of 248～496 parts of Rhizoma Anemarrhenaes of Radix Salviae Miltiorrhizae
Optimum weight part is:
331 parts of 662 portions of Rhizoma Dioscoreaes of 662 parts of Exocarpium Benincasaes of Folium Panacis Quinquefolii
220 parts of 331 portions of Radix Rehmanniae of 331 parts of Rhizoma Anemarrhenaes of Radix Salviae Miltiorrhizae
Technical problem to be solved by this invention is to realize by following technical scheme.Be characterized in the medicine that Folium Panacis Quinquefolii, Exocarpium Benincasae, Radix Salviae Miltiorrhizae, the Rhizoma Anemarrhenae, Radix Rehmanniae, Rhizoma Dioscoreae etc. are made for raw material.A kind of Chinese medicine composition for the treatment of diabetes of this treatment diabetes is characterized in that it is that component is formed or made active component and pharmaceutically acceptable additives are formed or make active component and pharmaceutically acceptable additives are formed by the alcohol extract of following main materials by the water extract of following main materials by following main materials.The present invention has the merit of nourishing YIN to lower pathogenic fire, removing damp-heat by scientific combination, development meticulously, also has the effect of strengthening vital QI to eliminate pathogenic factors concurrently, and is remarkable to each paradiabetes effect.
Described pharmaceutically acceptable additives are following one or more: glycerol, gelatin, Polyethylene Glycol, glycerol monolaurate (gelucire44/14), propylene glycol, dextrin, ethanol, dried starch, citric acid, sodium bicarbonate, ethyl hydroxybenzoate, tartaric acid, lecithin, sodium lauryl sulphate.
Its dosage form can be a said dosage form on any pharmaceutics, as syrup, granule, capsule, tablet etc.; Described capsule can be common capsule, effervescent capsule or other various suitable capsules; Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can be with suitable coating material coating also coating not; The preferred particulates agent.
The specific embodiment
Describe implementation of the present invention in detail below in conjunction with embodiment.
Embodiment 1:
The preparation method of dissolved granule of the present invention: coarser powder is ground in the pulverizing of medicines such as Folium Panacis Quinquefolii 500 grams, Exocarpium Benincasae 500 grams, Rhizoma Dioscoreae 500 grams, Radix Salviae Miltiorrhizae 500 grams, the Rhizoma Anemarrhenae 500 grams, Radix Rehmanniae 250 grams, the decocting secondary, 2 hours for the first time, 1 hour for the second time, to filter, filtrate is condensed into thick paste, dry, pulverized 100 mesh sieves, mixing, moistening, soften, take out when forming agglomerate, make granule.
Embodiment 2:
The preparation method of syrup of the present invention:, each 1 hour, filter with Folium Panacis Quinquefolii 600 grams, Exocarpium Benincasae skin 600 grams, Rhizoma Dioscoreae 450 grams, Radix Salviae Miltiorrhizae 450 grams, the Rhizoma Anemarrhenae 450 grams, Radix Rehmanniae 350 gram decocting secondaries, merging filtrate, be condensed into thick paste, add the ethanol precipitation secondary, make to contain pure flow control and once reach 65%, for the second time reach 80%, filter, reclaim ethanol and be concentrated into about 700mL, add an amount of ethyl hydroxybenzoate alcohol liquid while hot and stir molten, add boiling water again to full dose, stir evenly promptly.
Embodiment 3:
The preparation method of medicated wine of the present invention:
Folium Panacis Quinquefolii 500 grams, Exocarpium Benincasae 500 grams, Rhizoma Dioscoreae 450 grams, Radix Salviae Miltiorrhizae 450 grams, the Rhizoma Anemarrhenae 450 grams, Radix Rehmanniae 350 each medicine of gram are cleaned, dried in the shade, section or broken then, and be immersed at 1: 4 in proportion in the rice white spirit that is equivalent to 45 ° of spirituosity degree, its brew cycle is 15～30 days, take out to after date, it is an amount of to add white sugar, filters bottling and gets final product.
In like manner, press the method for embodiment 1, add suitable capsule etc.
The present invention is made as fragrant faint yellow granule or sepia syrup or tablet or medicated wine or capsule, and is nontoxic.
More than during each forms, weight is calculated with crude drug, in the present invention, if weight is unit with the gram, this composition can be made into 1000 doses of pharmaceutical preparatioies, described 1000 doses of fingers, 1000 doses in the final drug preparation of making, as make 1000 in 1000 of capsule preparations, 1000 in tablet, granule 1000g, oral liquid 1000 peace bottles, injection 1000 peace bottles, drop pill etc., also can make big packing as granule, as the 100-500 bag, specifically can be 100 bags, 150 bags, 200 bags, 250 bags, 500 bags, every bag can be used as dose 1 time.This weight of formulation can increase or reduce, but the raw medicinal herbs weight proportion constant rate between each composition.
The present invention be at distinguished veteran doctors of TCM on the basis of proved recipe, through a large amount of preparation technology test and the resulting pure Chinese medicinal preparation of clinical practice.Treating both the principal and secondary aspects of a disease of the present invention, evident in efficacy, the improvement of all kinds of diabetic symptoms and the rehabilitation of promotion patient body are had the obvious treatment effect.
Advantage of the present invention is to compare with similar Western medicine, its have reasonable recipe, evident in efficacy, do not have irritated reaction, have no side effect, treatment cycle is short, and low price the patient easily accept, taking convenience, mouthfeel be good, suitable advantage such as takes for a long time, is a kind of ideal pure Chinese medicinal preparation that is used for the treatment of diabetes.
For a better understanding of the present invention, below further set forth medicine of the present invention at clinical action effect, but not to the restriction of effect of the present invention.
Concrete clinical practice is as follows:
1. clinical subjects: 90 examples in the treatment group of the present invention, male 60 examples, women 30 examples.50 examples are organized in treatment, matched group 40 examples, the course of disease 1～3 year.The general use 3 courses of treatment of medicine of the present invention, 3 months each courses of treatment.Matched group gives diabetes pill oral, and every day three times, year time is the same with the medication group, takes continuously 9 months.The results are shown in following table.
2. clinical test results is as follows:
Characteristics of the present invention are:
1. be All Pure Nature medicine preparation, have merit nourishing Yin and falling fire, removing damp-heat, also have the effect of strengthening vital QI to eliminate pathogenic factors concurrently, remarkable to all kinds of diabetes effects.
2. in use clinical symptoms are obviously improved, curative effect raising, short, cheap, no allergic reaction of cycle and toxic and side effect;
3. adopt oral formulation, easy to use, mouthfeel is good, and the patient easily accepts;
4. treatment cost is low, can save expense more than 61% than conventional therapy.
Claims (7)
1. Chinese medicine composition for the treatment of diabetes, it is characterized in that: it makes active component by the water extract of following raw materials according and pharmaceutically receptible additives are formed, and the weight portion of each raw material is: 165～275 parts of 248～496 portions of Radix Rehmanniae of 248～496 parts of Rhizoma Anemarrhenaes of 248～496 parts of Radix Salviae Miltiorrhizaes of 498～998 portions of Rhizoma Dioscoreaes of 498～998 parts of Exocarpium Benincasaes of Folium Panacis Quinquefolii.
2. a kind of Chinese medicine composition for the treatment of diabetes according to claim 1, it is characterized in that: the weight portion of described each raw material is:
331 parts of 662 portions of Rhizoma Dioscoreaes of 662 parts of Exocarpium Benincasaes of Folium Panacis Quinquefolii
220 parts of 331 portions of Radix Rehmanniae of 331 parts of Rhizoma Anemarrhenaes of Radix Salviae Miltiorrhizae.
3. a kind of Chinese medicine composition for the treatment of diabetes according to claim 1 is characterized in that: described pharmaceutically receptible additives are following more than one: lactose, starch, glycerol, ethyl hydroxybenzoate, gelatin, Polyethylene Glycol carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose, sucrose or xylitol.
4. a kind of Chinese medicine composition for the treatment of diabetes according to claim 1 is characterized in that: its dosage form is effervescent granule electuary, capsule or tablet.
5. a kind of Chinese medicine composition for the treatment of diabetes according to claim 4 is characterized in that: described capsule is the effervescent capsule.
6. a kind of Chinese medicine composition for the treatment of diabetes according to claim 4 is characterized in that: described tablet is effervescent tablet or is dispersible tablet, with suitable coating material coating.
7. a kind of preparation method for the treatment of the Chinese medicine composition of diabetes as claimed in claim 1, it is characterized in that: comprise the steps: to take by weighing by weight each raw material, said medicine is pulverized ground into coarser powder, decocting secondary, 2 hours for the first time, 1 hour for the second time, to filter, filtrate is condensed into thick paste, dry, pulverized 100 mesh sieves, mixing, moistening, soften, take out when forming agglomerate, make granule.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510061808 CN1814123B (en) | 2005-12-05 | 2005-12-05 | Chinese medicine composition for treating diabetes and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510061808 CN1814123B (en) | 2005-12-05 | 2005-12-05 | Chinese medicine composition for treating diabetes and its preparation method |
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| CN1814123A CN1814123A (en) | 2006-08-09 |
| CN1814123B true CN1814123B (en) | 2010-12-08 |
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| CN 200510061808 Expired - Fee Related CN1814123B (en) | 2005-12-05 | 2005-12-05 | Chinese medicine composition for treating diabetes and its preparation method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102150844B (en) * | 2010-12-31 | 2014-04-02 | 王钢柱 | Dried noodles with function of treating diabetes and preparation method of dried noodles |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1050299C (en) * | 1996-09-16 | 2000-03-15 | 刘坤范 | Decoction for lowering glucose in urine and quenching thirst |
| CN1634166A (en) * | 2003-12-30 | 2005-07-06 | 王胜霞 | Medicine for treating diabetes and its preparation method |
| CN1660339A (en) * | 2005-01-05 | 2005-08-31 | 段炼 | 'Sanxiaoling' capsule |
-
2005
- 2005-12-05 CN CN 200510061808 patent/CN1814123B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1050299C (en) * | 1996-09-16 | 2000-03-15 | 刘坤范 | Decoction for lowering glucose in urine and quenching thirst |
| CN1634166A (en) * | 2003-12-30 | 2005-07-06 | 王胜霞 | Medicine for treating diabetes and its preparation method |
| CN1660339A (en) * | 2005-01-05 | 2005-08-31 | 段炼 | 'Sanxiaoling' capsule |
Non-Patent Citations (4)
| Title |
|---|
| 冯建华等.第四届中医糖尿病学术会议述要.中医杂志39 6.1998,39(6),374-376. |
| 冯建华等.第四届中医糖尿病学术会议述要.中医杂志39 6.1998,39(6),374-376. * |
| 王文华等.糖尿速康胶囊治疗II型糖尿病80例.中国中医药科技8 5.2001,8(5),338. |
| 王文华等.糖尿速康胶囊治疗II型糖尿病80例.中国中医药科技8 5.2001,8(5),338. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102150844B (en) * | 2010-12-31 | 2014-04-02 | 王钢柱 | Dried noodles with function of treating diabetes and preparation method of dried noodles |
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| CN1814123A (en) | 2006-08-09 |
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Granted publication date: 20101208 Termination date: 20131205 |