CN1103599C - Chenxia medicament for relieving asthma and its pren. tech. - Google Patents
Chenxia medicament for relieving asthma and its pren. tech. Download PDFInfo
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Abstract
The present invention discloses a medicine for relieving asthma, which is composed of bupleurum root, baical skullcap root, gambir plant, pinellia tuber, ledebouriella root and semen lepidii. Pericarpium trichosanthis, orange fruit, white peony alba, ephedrae, red sage root, hogfenneL root, earth worm, etc. can also be added according to the situation of accompanied symptoms and signs. The medicine can effectively treat asthma diseases with a method of regulating the liver and nourishing the lung.
Description
The present invention is a kind of medicine for the treatment of asthma, specifically be a kind of be the Chinese patent medicine of the treatment bronchial asthma that is prepared from of medicine components with the Chinese herbal medicine, belong to drug world.
Asthma is common clinical, frequently-occurring disease, difficult treatment.Along with industrial development, atmospheric pollution increase the weight of and the fast pace of social life, sickness rate, mortality rate are worldwide ascendant trend in recent years.According to World Health Organization's statistics, the whole world has 100,000,000 6 thousand ten thousand bronchial asthma patients approximately, and China's primary disease sickness rate is 2.5-11.9%, and the serious harm people's is healthy, is the problem that is worth dark people's research.
For the treatment of asthma attack phase, doctor trained in Western medicine is with antiinflammatory, spasmolytic, and desensitization is main, though controlling symptoms is fast, easily recurrence after the right drug withdrawal, some medicine such as hormone etc., clothes have many side effect for a long time.The traditional Chinese medical science is abided by " roar and divide cold and heat " more, and the principle of " both having sent out to attack pathogen is urgency " focuses on and controls lung.The research report for the treatment of the lung and kidney simultaneously, treating both the principal and the secondary aspects of a disease at the same time is also arranged, and curative effect is better than controlling merely lung, but mostly Chinese medicine asthma be according to clinical experience, and with the diseaseization side of making arrangement after due consideration, based on decoction, Chinese patent medicine is less, present commercially available Chinese patent medicine " GUILONG KECHUANNING "." Gecko Dingchuan sheet "." lung precious triple effect sheet " waits or is not satisfied because of non-pure Chinese medicinal preparation or curative effect, do not satisfy clinical needs far away, about the development of asthma drug also very few.Shang Weijian has from the report of conditioning liver pulmonary function staff treatment asthma.
The present invention seeks to transfer liver reason lung method is guideline, and a kind of Chinese patent medicine for the treatment of asthma is provided.
The inventor is based on the accumulation of clinical practice for many years, think that asthma attack mostly is deficiency in origin and combines with the domination of pathogen, its sick position is at lung, and in close relations with liver, wind Sheng, QI rising in reverse order, stagnation of phlegm, blood stasis, the imbalance of liver pulmonary function are the pathogenesis keys of asthma, pay attention to harmonizing the functional activities of vital QI, tonneau QI and blood, eliminating pathogenic factor for supporting vital QI in the treatment, help lung a surname to fall, advocate, obtain better clinical efficacy with transferring liver reason lung method, and sum up new drug evident in efficacy, finished the present invention.
Basic composition is of medicine of the present invention: (weight portion)
Radix Bupleuri 5-15 Radix Scutellariae 5-15
The pharmaceutical composition that the above component of Rhizoma Pinelliae 5-15 Radix Saposhnikoviae 5-15 is formed is that the core of medicine of the present invention is formed.The medicament that said composition is made can reach the good result for the treatment of asthma.
According to the variation of clinical symptoms, can on the basis of above-mentioned composition, change sanction.Below provide two kinds of prescriptions to change based on above-mentioned core component.
Wherein a kind of for having increased Pericarpium Trichosanthis, Fructus Aurantii, the Radix Paeoniae Alba on the basis of the above, Herba Ephedrae, Radix Salviae Miltiorrhizae, Ramulus Uncariae Cum Uncis, Semen Lepidii (Semen Descurainiae), compositions composed as follows: (weight portion)
Radix Scutellariae 5-15 Rhizoma Pinelliae 5-15 Radix Bupleuri 5-15 Pericarpium Trichosanthis 8-20
Fructus Aurantii 5-15 Radix Paeoniae Alba 5-15 Herba Ephedrae 3-10 Radix Salviae Miltiorrhizae 6-18
Ramulus Uncariae Cum Uncis 6-18 Radix Saposhnikoviae 5-15 Semen Lepidii (Semen Descurainiae) 6-18
The preferred weight proportioning of above-mentioned composition is:
Radix Scutellariae 10 Rhizoma Pinelliaes 10 Radix Bupleuri 10 Pericarpium Trichosanthiss 15
Fructus Aurantii 10 Radix Paeoniae Albas 10 Herba Ephedraes 6 Radix Salviae Miltiorrhizaes 12
Ramulus Uncariae Cum Uncis 12 Radix Saposhnikoviaes 10 Semen Lepidii (Semen Descurainiae)s 12
Another kind of on above-mentioned core component basis, to increase Fructus Trichosanthis, the Radix Paeoniae Alba, Radix Peucedani, Herba Ephedrae, Pheretima, Radix Salviae Miltiorrhizae, Semen Lepidii (Semen Descurainiae), form following compositions:
Radix Bupleuri 5-15 Semen Lepidii (Semen Descurainiae) 6-18 Fructus Trichosanthis 8-20
Radix Scutellariae 5-15 Rhizoma Pinelliae 5-15 Radix Saposhnikoviae 5-15
Radix Paeoniae Alba 5-15 Herba Ephedrae 3-10 Pheretima 8-20
Radix Salviae Miltiorrhizae 6-18 Radix Peucedani 5-15
In the middle of above-mentioned a series of pharmaceutical compositions of the present invention, the Rhizoma Pinelliae preferably uses Rhizoma Pinelliae, and Herba Ephedrae is preferably used Herba Ephedrae (processed).
Described pharmaceutical composition of the present invention.Can directly be ground into fine powder, after sieving, make powder or encapsulated.
Also above-mentioned pharmaceutical composition can be decocted with water, make oral decoction.
Perhaps each component in the compositions is carried out active ingredient and extract, make common formulations, as tablet, pill, powder, unguentum, syrup, tincture, aerosol, oral liquid, capsule, electuary, injection etc.
The preferred composition of preparation medicine of the present invention is: (weight portion)
Radix Scutellariae 5-15 Rhizoma Pinelliae 5-15 Radix Bupleuri 5-15
Pericarpium Trichosanthis 8-20 Fructus Aurantii 5-15 Radix Paeoniae Alba 5-15
Herba Ephedrae 3-10 Radix Salviae Miltiorrhizae 6-18 Ramulus Uncariae Cum Uncis 6-18
Radix Saposhnikoviae 5-15 Semen Lepidii (Semen Descurainiae) 6-18
The preferred dosage form of medicine of the present invention is an electuary, the technology of preparation electuary any in the middle of can following two kinds of technologies:
Preparation technology 1
Radix Scutellariae adds decocting in water and carries twice, filters, and the water extract adds concentrated hydrochloric acid and transfers PH
1-2, 80 ℃ the insulation 20-60 minute, leave standstill, the leaching precipitate, 60 ℃ of dryings, pulverize the baicalin crude product.The Rhizoma Pinelliae, Radix Bupleuri, Pericarpium Trichosanthis, the Radix Paeoniae Alba, Herba Ephedrae, Fructus Aurantii add decocting in water and carry twice, and the water extract is concentrated into relative density 1.02-1.04 (60 ℃), adds ethanol, and cold preservation is filtered, and filtrate recycling ethanol is concentrated into relative density 1.25-1.30 (60 ℃) clear paste; Radix Salviae Miltiorrhizae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Semen Lepidii (Semen Descurainiae) 60-80% alcohol reflux 2 times, the alcohol extract decompression recycling ethanol is concentrated into relative density 1.25-1.30 (60 ℃) clear paste.Above-mentioned two parts clear paste is mixed, drying under reduced pressure (80 ℃ of 0.08MPa), dry extract, pulverize and with baicalin crude product mix homogeneously, add an amount of excipient system granule; Drying, granulate, sub-dose packaging are promptly.
Preparation technology 2
Radix Scutellariae adds decocting in water to be carried 2 times, filters, and the water extract is transferred PH with concentrated hydrochloric acid
1-2, 80 ℃ are incubated 20-60 minute, leave standstill, and the baicalin crude product is separated out, the leaching precipitation, and 60 ℃ of dryings, standby after pulverizing.The Rhizoma Pinelliae, Radix Bupleuri, Pericarpium Trichosanthis, the Radix Paeoniae Alba, Herba Ephedrae, Fructus Aurantii add decocting in water to be carried 2 times, and the water extract is concentrated into relative density 1.04-1.08 (60 ℃) through the high speed centrifugation remove impurity; Radix Salviae Miltiorrhizae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Semen Lepidii (Semen Descurainiae) 60-80% ethanol extraction 2 times, the alcohol extract decompression recycling ethanol, being concentrated into relative density 1.04-1.08 (60 ℃) merges above two parts concentrated solution, spray drying, promptly get dry extract, excipient such as adding baicalin crude product and an amount of lactose, soluble starch, dextrin, ethanol are an amount of, mix homogeneously, dry granulation, sub-dose packaging are promptly.
Preferred pharmaceutical compositions of the present invention is compared with the medicine of existing treatment asthma, and its principles of formulating prescriptions and medication characteristics are as follows:
The Radix Bupleuri bitter in the mouth is slightly cold in the side, returns the liver and gall warp, and body is thin through gas, and the property master rises diffusing, can saturating flesh table and few sun, and soothing the liver strongly fragrant, clearing away liver-fire and sharp important department.Bencao Congxin " meaning: " it is up to draw clearing heat in QI system, and the faint pathogenic heat of the moon of flat few sun are declared smooth QI and blood." Semen Lepidii (Semen Descurainiae) returns lung, urinary bladder channel, pungent drugs can disperse and bitter drugs can descend, its property Great Cold, heap soil or fertilizer over and around the roots that can the using pungent drugs for dispersion and bitter drugs for purgation lung qi is closed, and is jammed the key medicine that QI rising in reverse order is breathed with cough for controlling the expectorant front yard.The two is 5, one livers, one lung mutually, and one rise and one drop starts outside the lifting and takes turns, and specially controls the stagnation of QI QI rising in reverse order of asthma, " atmosphere one changes, and its gas is diffusing " (" Medical Treasures of the Golden Chamber, aqueous vapor abnormal pulse card also controls the 14 ").So be monarch drug.Cold in nature and the matter of Fructus Trichosanthis sweet in the mouth profit, existing removing heat-phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, the merit of loosening bowel to relieve constipation has the effect of suppressing the hyperactive liver soothing liver-QI again.This says and sees " Chongqing hall random notes ": " ... and do not know that its (referring to Fructus Trichosanthis) soothing liver-QI is strongly fragrant, the profit liver is dry, suppressing the hyperactive liver is contrary, the merit of slow liver breath have solely arrogate to oneself also ".Radix Scutellariae gas book bitter in the mouth, cold in nature and lung is returned in heat clearing away, gallbladder and large intestine channel, kind clearing away lung-heat and pathogenic fire purging.Rhizoma Pinelliae acrid in the mouth gas is flat, and is hot with relieving accumulation of pathogens, flat with sending down the abnormal ascending QI, can " the full knot of diabetes with polydipsia as the prominent symptom abdomen chest and diaphragm expectorant heat, cough with dyspnea " (" not Lu "), three medicines are harmonious, the meaning of the little sunken chest of residing is played the chest stuffiness relieving altogether and is regulated the flow of vital energy removing heat-phlegm.Ramulus Uncariae Cum Uncis is sweet cold, returns Liver Channel, energy clearing away liver-fire, suppressing the hyperactive liver sun, relieving spasm by subduing liver-wind.Radix Saposhnikoviae acrid-sweet flavor tepor is returned the liver lung meridian, all wind of extensively treating, and the exogenous wind of can dispelling has the endogenous wind of putting out again, more can dispersing the stagnated live-QI to relieve the stagnation of QI and help Radix Bupleuri to transfer the power of liver.Radix Paeoniae Alba acid sweetness and bitterness is slightly cold, the yin fluid astringing that can nourish blood, and easing the affected liver to relieve pain, suppressing liver-YANG is defeated a force with a tenderness.Six medicines phase 5.Dispelling pathogenic wind and eliminating phlegm, promoting blood circulation to remove obstruction in the collateral, principal drug assistance are transferred liver reason lung, so be ministerial drug.The Herba Ephedrae acrid in the mouth is warm in nature, but depressed lung-energy dispersing, expelling cold and relieving exterior syndrome; Fructus Aurantii is regulated the flow of vital energy descending, and sending down the abnormal ascending QI is to relieving asthma.Radix Salviae Miltiorrhizae, bitter in the mouth and be slightly cold the GUIXIN Liver Channel.Radix Salviae Miltiorrhizae simply, merit be with four things, the merit that the power of its activating blood circulation is enriched blood greater than nourishing blood, with logical be benefits, in reach internal organs and blood stasis dispelling stagnates, outer sharp joint and the network of promoting blood circulation, the stasis of blood stagnates and dispels, venation is led to, important department's profit, then ascending or descending movement of vital Qi discrepancy is freely.The Radix Salviae Miltiorrhizae and the Radix Paeoniae Alba are harmonious, and can prevent that sufferings such as Radix Bupleuri, Radix Saposhnikoviae, Herba Ephedrae are diffusing too, and consumption impairment of QI the moon has receipts during this promptly puts, close in opening.Radix Salviae Miltiorrhizae and anti-wind facies 5, then more residing has the meaning of " control wind and control blood earlier, the blood sector-style is from going out ".Be adjuvant drug altogether.The inventor uses Herba Ephedrae in this side, more be original and different.Herba Ephedrae processed with honey, and consumption minimum.Get its hot hardship of loosing first and let out, Wen Tongxuan is smooth, the external enwergy dispersing wind-cold, and the internal energy lung qi dispersing gas of opening has the merit of good depressed lung-energy dispersing; Get its master first and go into lung meridian, have more the energy of guiding action, so be adjuvant.Make a general survey of full side, focus on and regulate the flow of vital energy, gas can be disappeared along wind then, fire, expectorant, strongly fragrant, the stasis of blood, heresy is dispelled and just from peace, then asthma can be put down.
The hot sweet bitter system of closing of prescription, soothing the liver and keep away to rise and loose, easing the affected liver is held concurrently to invigorate blood circulation, yin nourishing and do not hold back heresy, eliminating evil and just do not hinder, close in " element is asked, opinion during the visceral-qi method " " liver is bitter anxious, anxious food sweet flavor has the effect of relaxing ", " the liver desire is loose; anxious food is hot to loose it; with hot benefits, acid is rushed down it ", and the legislation principles of " the lung being apt to suffer from adverse rising of QI; anxious food is bitter to rush down it ", embodied more all sidedly and transferred liver to manage the various aspects of lung method.
Medicine of the present invention shows to have the effect of good curing asthma through clinical research and pharmacological experiment study.
Clinical observation result: (1) selects bronchial asthma patient 140 examples, and be divided into treatment at random and organize 100 examples, matched group 40 examples, treatment group a kind of reed mentioned in ancient books summer Dingchuan electuary, matched group depressed lung-energy dispersing side, be two weeks the course of treatment.The comprehensive therapeutic effect evaluation, it is 64.0% that treatment shows the control rate, and effective percentage is 97.5%, and through the Ridit check, p＜0.05 has significant difference; Simultaneously, individual event curative effect statistics shows that a kind of reed mentioned in ancient books summer Dingchuan electuary is being relievingd asthma, and reduces phlegm, and invigorates blood circulation and antiinflammatory, antiallergic aspect are better than the depressed lung-energy dispersing Circulation Resolving Phlegm.(2) pulmonary function and blood gas analysis objective indicator statistics shows that a kind of reed mentioned in ancient books summer Dingchuan electuary has the lung capacity of improvement, pulmonary ventilation function, corrects the remarkable effect of histanoxia and carbon dioxide retention, changes t check p＜0.01,0.05 before and after the treatment.Wherein,, improve and breathe the flow velocity in mid-term, reduce little airway resistance, improve the blood oxygen pressure aspect and be better than matched group, p＜0.05 reducing residual volume of lung.
Experimental studies results: (1) comprises measured by radioimmunoassay asthmatic patient expectorant, blood lgG, lgE to Immune Effects, lgA, and oudin's technique is measured blood lgG, lgM, lgA, SC C
3, C
4,
3H mixes people's method and measures the lymphocyte turnover number, the result shows that asthma attack phase patient's blood lgG, lgE obviously increase than the normal person, blood lgE, the lgG of a kind of reed mentioned in ancient books summer Dingchuan electuary to increasing, lgM improves significantly, P＜0.01,0.05, wherein be better than matched group, p＜0.05 aspect the effect that reduces lgG.(2) to hemorheological influence, comprise platelet count, adhesion rate, thrombelastogram, variation before and after whole blood viscosity, plasma viscosity and the packed cell volume treatment, statistical result shows, a kind of reed mentioned in ancient books summer, the Dingchuan electuary was to hyperfunction platelet adhesion, aggregation capability has stronger inhibitory action, p＜0.01,0.05; Part index number to thrombelastogram has some improvement, p＜0.05; Reduce the whole blood viscosity that increases, P＜0.05.(3) zoopery shows, a kind of reed mentioned in ancient books summer Dingchuan electuary is the minimizing of the stripped lung airway perfusion amount of prolonged guinea pig obviously, and guinea pig model airway tissue inflammatory reaction is had significant protection and antiinflammatory action.
Embodiment 1
Prescription:
Radix Scutellariae 10g Rhizoma Pinelliae 10g Radix Bupleuri 10g Pericarpium Trichosanthis 15g
Fructus Aurantii 10g Radix Paeoniae Alba 10g Herba Ephedrae 6g Radix Salviae Miltiorrhizae 12g
Ramulus Uncariae Cum Uncis 12g Radix Saposhnikoviae 10g Semen Lepidii (Semen Descurainiae) 12g
Method for making:
Radix Scutellariae adds decocting in water and puies forward (the 1st 8 times of amounts, the 2nd 6 times of amounts were respectively boiled 1 hour) 2 times, filters, and the water extract adds concentrated hydrochloric acid and transfers PH
1-2, 80 ℃ the insulation 30 minutes, left standstill 24 hours, the leaching precipitate, 60 ℃ of dryings, pulverize the baicalin crude product; The Rhizoma Pinelliae, Radix Bupleuri, Pericarpium Trichosanthis, the Radix Paeoniae Alba, Herba Ephedrae, Fructus Aurantii add decocting in water and carry 2 times and (add 10 times in water the 1st time, boiled 2 hours, add 8 times in water the 2nd time, boiled 1 hour), the water extract is concentrated into relative density 1.02-1.04 (60 ℃), the amount of doubling ethanol, cold preservation 12 hours, filter, filtrate recycling ethanol is concentrated into relative density 1.25-1.30 (60 ℃) clear paste; Radix Salviae Miltiorrhizae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Semen Lepidii (Semen Descurainiae) are with 70% alcohol reflux 2 times (add 8 times of ethanol the 1st time, extracted 2 hours, the 2nd time add 6 times of amounts of ethanol, extracted 1 hour), and the alcohol extract decompression recycling ethanol is concentrated into relative density 1.25-1.30 (60 ℃) clear paste.Above-mentioned two parts clear paste is mixed, drying under reduced pressure (0.08MPa, 80 ℃), dry extract, pulverize and mix and contain evenly with the baicalin crude product, add an amount of excipient (dextrin, ethanol etc.) system granule; Drying, granulate, sub-dose packaging are promptly.
Embodiment 2: prescription Radix Scutellariae 15 Rhizoma Pinelliaes 5 Radix Bupleuri 15 Pericarpium Trichosanthiss 8 Fructus Aurantiis 15 Radix Paeoniae Albas 5 Herba Ephedraes 3 Radix Salviae Miltiorrhizaes 18 Ramulus Uncariae Cum Uncis 6 Radix Saposhnikoviaes 15 Semen Lepidii (Semen Descurainiae)s 18 method for makings
Radix Scutellariae adds decocting in water and puies forward (the 1st 8 times of amounts, the 2nd 6 times of amounts were respectively boiled 1 hour) 2 times, filters, and the water extract is transferred PH with concentrated hydrochloric acid
1-2, 80 ℃ are incubated 30 minutes, left standstill 24 hours, the baicalin crude product is separated out, the leaching precipitation, 60 ℃ of dryings, standby after pulverizing, the Rhizoma Pinelliae, Radix Bupleuri, Pericarpium Trichosanthis, the Radix Paeoniae Alba, Herba Ephedrae, Fructus Aurantii add decocting in water and carry 2 times and (add 10 times in water the 1st time, boiled 2 hours, and added 8 times in water, boiled 1 hour for the 2nd time), the water extract is concentrated into relative density 1.04-1.08 (60 ℃) through high speed centrifugation (more than the 1600r/min) remove impurity; Radix Salviae Miltiorrhizae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Semen Lepidii (Semen Descurainiae) with 70% ethanol extraction 2 times (the 1st time 8 times 2 hours, the 2nd time 6 times 1 hour), the alcohol extract decompression recycling ethanol is concentrated into relative density 1.04-1.08 (60 ℃); Above two parts concentrated solution is merged, and spray drying promptly gets dry extract, and excipient such as adding baicalin crude product and an amount of lactose, soluble starch, dextrin, ethanol are an amount of, mix homogeneously, and dry granulation, sub-dose packaging are promptly.
Claims (10)
1, a kind of pharmaceutical composition for the treatment of asthma is characterized in that said composition made by following raw medicaments in portion by weight:
Radix Bupleuri 5-15 weight portion Radix Scutellariae 5-15 weight portion
Rhizoma Pinelliae 5-15 weight portion Radix Saposhnikoviae 5-15 weight portion.
2, a kind of pharmaceutical composition for the treatment of asthma is characterized in that said composition made by following raw medicaments in portion by weight:
Radix Scutellariae 5-15 weight portion Rhizoma Pinelliae 5-15 weight portion Radix Bupleuri 5-15 weight portion
Pericarpium Trichosanthis 8-20 weight portion Fructus Aurantii 5-15 weight portion Radix Paeoniae Alba 5-15 weight portion
Herba Ephedrae 3-10 weight portion Radix Salviae Miltiorrhizae 6-18 weight portion Ramulus Uncariae Cum Uncis 6-18 weight portion
Radix Saposhnikoviae 5-15 weight portion Semen Lepidii (Semen Descurainiae) 6-18 weight portion.
3,, it is characterized in that said composition made by following raw medicaments in portion by weight: the Radix Scutellariae 10 weight portion Rhizoma Pinelliaes 10 weight portion Radix Bupleuri 10 weight portion Pericarpium Trichosanthiss 15 weight portion Fructus Aurantiis 10 weight portion Radix Paeoniae Albas 10 weight portion Herba Ephedraes 6 weight portion Radix Salviae Miltiorrhizaes 12 weight portion Ramulus Uncariae Cum Uncis 12 weight portion Radix Saposhnikoviaes 10 weight portion Semen Lepidii (Semen Descurainiae)s 12 weight portions according to the pharmaceutical composition of claim 2.
4, a kind of pharmaceutical composition for the treatment of asthma is characterized in that said composition made by following raw medicaments in portion by weight:
Radix Bupleuri 5-15 weight portion Semen Lepidii (Semen Descurainiae) 6-18 weight portion Fructus Trichosanthis 8-20 weight portion
Radix Scutellariae 5-15 weight portion Rhizoma Pinelliae 5-15 weight portion Radix Saposhnikoviae 5-15 weight portion
Radix Paeoniae Alba 5-15 weight portion Herba Ephedrae 3-10 weight portion Pheretima 8-20 weight portion
Radix Salviae Miltiorrhizae 6-18 weight portion Radix Peucedani 5-15 weight portion
5,, it is characterized in that the said Rhizoma Pinelliae is a Rhizoma Pinelliae according to each described pharmaceutical composition of claim 1-4.
6,, it is characterized in that said Herba Ephedrae is a Herba Ephedrae (processed) according to each described pharmaceutical composition of claim 2-4.
7, a kind of preparation of drug combination method for the treatment of asthma is characterized in that the proportioning raw materials of this method and method for making are:
Radix Scutellariae 5-15 weight portion Rhizoma Pinelliae 5-15 weight portion Radix Bupleuri 5-15 weight portion
Pericarpium Trichosanthis 8-20 weight portion Fructus Aurantii 5-15 weight portion Radix Paeoniae Alba 5-15 weight portion
Herba Ephedrae 3-10 weight portion Radix Salviae Miltiorrhizae 6-18 weight portion Ramulus Uncariae Cum Uncis 6-18 weight portion
Radix Saposhnikoviae 5-15 weight portion Semen Lepidii (Semen Descurainiae) 6-18 weight portion
Radix Scutellariae adds decocting in water and carries twice, filters, and the water extract adds concentrated hydrochloric acid and transfers PH
1-2, 80 ℃ are incubated 20-60 minute, leave standstill leaching precipitate, drying, pulverize the baicalin crude product, the Rhizoma Pinelliae, Radix Bupleuri, Pericarpium Trichosanthis, the Radix Paeoniae Alba, Herba Ephedrae, Fructus Aurantii add decocting in water and carry twice, the water extract is concentrated into relative density 1.02-1.04, adds ethanol, cold preservation is filtered, and filtrate recycling ethanol is condensed into clear paste; Radix Salviae Miltiorrhizae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Semen Lepidii (Semen Descurainiae) 60-80% alcohol reflux 2 times, the alcohol extract decompression recycling ethanol is condensed into clear paste; Above-mentioned two parts clear paste is mixed, drying, dry extract, pulverize and with baicalin crude product mix homogeneously, add an amount of excipient and make granule, drying, granulate, promptly.
8, according to the preparation method of claim 7, its feature in the proportioning raw materials and the method for making of this method is: the Radix Scutellariae 10 weight portion Rhizoma Pinelliaes 10 weight portion Radix Bupleuri 10 weight portion Pericarpium Trichosanthiss 15 weight portion Fructus Aurantiis 10 weight portion Radix Paeoniae Albas 10 weight portion Herba Ephedraes 6 weight portion Radix Salviae Miltiorrhizaes 12 weight portion Ramulus Uncariae Cum Uncis 12 weight portion Radix Saposhnikoviaes 10 weight portion Semen Lepidii (Semen Descurainiae)s 12 weight portion Radix Scutellariaes add decocting in water and carry 2 times, add 8 times of amounts of water for the 1st time, add 6 times of amounts of water for the 2nd time, respectively boiled 1 hour, filter, the water extract adds concentrated hydrochloric acid and transfers PH
1-2, 80 ℃ the insulation 30 minutes, left standstill 24 hours, the leaching precipitate, 60 ℃ of dryings, pulverize the baicalin crude product; The Rhizoma Pinelliae, Radix Bupleuri, Pericarpium Trichosanthis, the Radix Paeoniae Alba, Herba Ephedrae, Fructus Aurantii add decocting in water and carry 2 times, add 10 times in water the 1st time, boiled 2 hours, and added 8 times in water, boiled 1 hour for the 2nd time, the water extract is concentrated into 60 ℃ of relative density 1.02-1.04, the amount of doubling ethanol, cold preservation 12 hours is filtered, filtrate recycling ethanol is concentrated into 60 ℃ of relative density 1.25-1.30 clear paste; Radix Salviae Miltiorrhizae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Semen Lepidii (Semen Descurainiae) be with 70% alcohol reflux 2 times, adds 8 times of ethanol, extracted 2 hours for the 1st time, add 6 times of amounts of ethanol for the 2nd time, extracted 1 hour, the alcohol extract decompression recycling ethanol is concentrated into 60 ℃ of relative density 1.25-1.30 clear paste, above-mentioned two parts clear paste is mixed, 0.08MPa 80 ℃ of drying under reduced pressure get dry extract, pulverize and with baicalin crude product mix homogeneously, add an amount of excipient dextrin, ethanol is made granule; Drying, the granulate sub-dose packaging promptly.
9, a kind of preparation of drug combination method for the treatment of asthma is characterized in that the proportioning raw materials of this method and method for making are:
Radix Scutellariae 5-15 weight portion Rhizoma Pinelliae 5-15 weight portion Radix Bupleuri 5-15 weight portion
Pericarpium Trichosanthis 8-20 weight portion Fructus Aurantii 5-15 weight portion Radix Paeoniae Alba 5-15 weight portion
Herba Ephedrae 3-10 weight portion Radix Salviae Miltiorrhizae 6-18 weight portion Ramulus Uncariae Cum Uncis 6-18 weight portion
Radix Saposhnikoviae 5-15 weight portion Semen Lepidii (Semen Descurainiae) 6-18 weight portion
Radix Scutellariae adds decocting in water and carries twice, filters, and the water extract is transferred PH with concentrated hydrochloric acid
1-2, 80 ℃ are incubated 20-60 minute, leave standstill, and the baicalin crude product is separated out, the leaching precipitation, 60 ℃ of dryings, standby after pulverizing, the Rhizoma Pinelliae, Radix Bupleuri, Pericarpium Trichosanthis, the Radix Paeoniae Alba, Herba Ephedrae, Fructus Aurantii add decocting in water to be carried 2 times, and the water extract is concentrated into relative density degree 1.04-1.08 through the high speed centrifugation remove impurity; Radix Salviae Miltiorrhizae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Semen Lepidii (Semen Descurainiae) 60-80% ethanol extraction 2 times, the alcohol extract decompression recycling ethanol is concentrated into relative density 1.04-1.08; Above two parts concentrated solution is merged, and spray drying promptly gets dry extract, adds baicalin crude product and excipient, mix homogeneously, and dry granulation, promptly.
10, according to the preparation method of claim 9, the proportioning raw materials and the technology that it is characterized in that this method are as follows: the Radix Scutellariae 10 weight portion Rhizoma Pinelliaes 10 weight portion Radix Bupleuri 10 weight portion Fructus Trichosanthis skins 15 weight portion Fructus Aurantiis 10 weight portion Radix Paeoniae Albas 10 weight portion Herba Ephedraes 6 weight portion Radix Salviae Miltiorrhizaes 12 weight portion Ramulus Uncariae Cum Uncis 12 weight portion Radix Saposhnikoviaes 10 weight portion Semen Lepidii (Semen Descurainiae)s 12 weight portion Radix Scutellariaes add decocting in water and carry 2 times, the 1st 8 times of amounts, the 2nd 6 times of amounts, respectively boiled 1 hour, filter, the water extract is transferred PH with concentrated hydrochloric acid
1-2, 80 ℃ are incubated 30 minutes, left standstill 24 hours, the baicalin crude product is separated out, leaching precipitation, 60 ℃ of dryings, it is standby to pulverize the back, the Rhizoma Pinelliae, Radix Bupleuri, Pericarpium Trichosanthis, the Radix Paeoniae Alba, Herba Ephedrae, Fructus Aurantii add decocting in water to be carried 2 times, adds 10 times in water, boils 2 hours for the 1st time, add 8 times in water the 2nd time, boiled 1 hour, the water extract is concentrated into 60 ℃ of relative density 1.04-1.08 through the above high speed centrifugation remove impurity of 1600r/min; Radix Salviae Miltiorrhizae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis; Semen Lepidii (Semen Descurainiae) is with 70% ethanol extraction 2 times, the 1st time 8 times 2 hours, the 2nd time 6 times 1 hour, the alcohol extract decompression recycling ethanol is concentrated into 60 ℃ of relative density 1.04-1.08; Above two parts concentrated solution is merged, and spray drying promptly gets dry extract, adds baicalin crude product and an amount of lactose, excipient such as soluble starch, dextrin, ethanol, and mix homogeneously, dry granulation, sub-dose packaging are promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98120580A CN1103599C (en) | 1998-10-26 | 1998-10-26 | Chenxia medicament for relieving asthma and its pren. tech. |
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| Application Number | Priority Date | Filing Date | Title |
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| CN98120580A CN1103599C (en) | 1998-10-26 | 1998-10-26 | Chenxia medicament for relieving asthma and its pren. tech. |
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| Publication Number | Publication Date |
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| CN1103599C true CN1103599C (en) | 2003-03-26 |
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| CN98120580A Expired - Fee Related CN1103599C (en) | 1998-10-26 | 1998-10-26 | Chenxia medicament for relieving asthma and its pren. tech. |
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| CN116173128A (en) * | 2023-04-04 | 2023-05-30 | 吉林省寰宇济民科技有限公司 | Traditional Chinese medicine composition and traditional Chinese medicine extract for reducing phlegm and clearing heat and preparation method thereof |
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1998
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Non-Patent Citations (3)
| Title |
|---|
| 上海中医药杂志，1991(6) 1991-01-01 肃泽民，"龙柴汤"加减治疗寒性哮喘83例 * |
| 山东中医学院学报，1995,19(20) 1995-01-01 李静，张洁承，活血定喘方治疗发作期支气管哮喘的研究 * |
| 山东中医学院学报，1995,19(20) 1995-01-01 李静，张洁承，活血定喘方治疗发作期支气管哮喘的研究;上海中医药杂志，1991(6) 1991-01-01 肃泽民，"龙柴汤"加减治疗寒性哮喘83例 * |
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