CN113332367A - Wild pineapple extract and application thereof in preparation of medicine for treating hyperuricemia - Google Patents
Wild pineapple extract and application thereof in preparation of medicine for treating hyperuricemia Download PDFInfo
- Publication number
- CN113332367A CN113332367A CN202110732019.5A CN202110732019A CN113332367A CN 113332367 A CN113332367 A CN 113332367A CN 202110732019 A CN202110732019 A CN 202110732019A CN 113332367 A CN113332367 A CN 113332367A
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- Prior art keywords
- extract
- parts
- wild pineapple
- wild
- traditional chinese
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Abstract
The invention provides a wild pineapple extract and application thereof in preparing a medicament for treating hyperuricemia, and relates to the technical field of traditional Chinese medicines. The wild pineapple extract is mainly prepared by sequentially concentrating and spray drying wild pineapple extract; the preparation method of the wild pineapple extracting solution comprises the following steps: firstly, pretreating fresh wild pineapple fruits to obtain wild pineapple powder; then, carrying out water extraction on the wild pineapple powder to obtain water extract and water extraction filter residue; then carrying out alcohol extraction on the water extraction filter residue to obtain an alcohol extract; and finally, uniformly mixing the water extract and the alcohol extract to obtain the wild pineapple extract. The wild pineapple extract prepared by the method has a good treatment effect on hyperuricemia, and the problem of side effects of the traditional Chinese medicine preparation for treating hyperuricemia, which contains severe coldness and toxic medicines, can be effectively solved by preparing the wild pineapple extract into the medicine for treating the hyperuricemia.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a wild pineapple extract and application thereof in preparing a medicine for treating hyperuricemia.
Background
Gout is an inflammatory disease induced by monosodium urate crystals, and Hyperuricemia (HUA) can be caused by long-term active purine metabolism, excessive purine uptake or uric acid excretion disorder. Long-term hyperuricemia can cause deposition of urate crystals in joints and surrounding soft tissues, and then repeated acute joint and soft tissue inflammation, tophus deposition, chronic arthritis and joint damage occur. At present, no practical and effective radical cure mode is available for gout and hyperuricemia clinically, the hyperuricemia becomes the second most metabolic disease next to diabetes, particularly, the prevalence rate of the HUA in economically developed areas of China reaches 5.0% -23.5% in economically developed cities and coastal areas, and the HUA rapidly increases at a rate of 9.7% per year. In 2019, the number of hyperuricemia patients in China reaches 1.7 hundred million, the number of gout patients exceeds 8000 ten million, and in 2020, the number of gout patients reaches 1 hundred million, and the tendency of high prevalence and young development is expected.
At present, western medicine treatment means for acute gouty arthritis comprise anti-inflammatory analgesics, glucocorticoids, uric acid reduction and the like, and clinically, medicaments for treating hyperuricemia mainly comprise benzbromarone, probenecid, allopurin and the like; but the adverse reaction is large, the gastrointestinal reaction is obvious, the clinical treatment is greatly limited along with the damage of liver and kidney functions, potential neurotoxicity, muscle toxicity and the like, and the traditional Chinese medicine has the advantages in the aspect of treating gout.
Gout belongs to the category of arthralgia syndrome in traditional Chinese medicine, the pathogenesis of gout is theorized by doctors, and the pathogenesis of gout is basically considered as follows: 1. disorder of transportation and transformation of the spleen and stomach, abnormal ascending and descending, water retention which cannot be distributed and dispersed, and accumulated in the middle-jiao to become damp, the damp-heat is transformed into heat for a long time, and the accumulation of damp-heat is the root cause of gout; 2. dampness-heat toxin can retain meridians, block and block meridians, and cause stagnation of qi and blood in joints, so that the joint is suffered from gout, which is manifested as acute swelling and pain of joints and gout; deficiency of the spleen and stomach, congenital impairment, liver and kidney deficiency, malnutrition of the tendons and vessels of the limbs, damp-heat pathogen obstructing the joints, obstructing the circulation of qi and blood, phlegm and blood stasis after a long time, further obstructing the joints, aggravating the disease condition, and manifesting as repeated pain of the joints or formation of tophus.
Gout is classified into type 4 according to the Chinese medicine industry standard of the people's republic of China, "the standard of curative effect for diagnosing traditional Chinese medicine diseases": damp-heat accumulation, stagnant heat stagnation, turbid phlegm stagnation, and liver-kidney yin deficiency. The common clinical symptoms are damp-heat accumulation type and stagnant heat blocking type, and the mechanism of treating gout in traditional Chinese medicine is that the basic etiology and pathogenesis of gout are considered in the traditional Chinese medicine treatment process: the food and drink are irregular and the spleen and stomach are disordered, and damp-heat is generated in the interior, so the clinical treatment is divided into: the traditional Chinese medicine composition has the main effects of tonifying spleen and promoting transportation, clearing heat and promoting diuresis, is supplemented with the effects of dredging collaterals and removing blood stasis, tonifying liver and relieving pain, and is also supplemented with the effects of tonifying spleen and discharging acid, and tonifying kidney and dissolving stones, so that a good treatment effect can be achieved.
Meanwhile, the traditional Chinese medicine for treating gout has more prescriptions, for example: the gout is generally prevented and treated by adopting traditional Chinese medicines for clearing heat, dispelling wind, dredging collaterals and promoting diuresis or traditional Chinese medicines for clearing heat, promoting diuresis, treating stranguria and removing calculus, common Chinese herbal medicines mainly comprise lysimachia christinae hance, lycopodium clavatum, sargentgloryvine stem and the like, the medicines are often severe cold and toxic, certain side effects exist, and the treatment effects of various formulas are not obvious. The traditional Chinese medicines are prepared by a traditional pharmaceutical method, and due to the disorder of the medicinal material sources, the traditional Chinese medicine gout preparation has the advantages of slow effect, long clinical medicine taking period, pain of patients in taking medicine and low acceptance, and a preparation technology of a high-efficiency anti-gout medicine without toxic or side effect is urgently needed to be developed. In addition, the phenomenon of easy recurrence is common in the clinical treatment of gout at present, strict diet control and irregular medicine taking are required, and a medicine capable of thoroughly relieving gout symptoms needs to be developed.
Therefore, researches and developments of a drug for treating hyperuricemia which is short in treatment course, quick in effect, high in clinical cure rate and not easy to relapse and is prepared from mild Chinese herbal medicine raw materials are necessary and urgent to solve the problem of side effects caused by the fact that the existing traditional Chinese medicine preparation for treating hyperuricemia often contains severe cold and toxic drugs.
In view of the above, the present invention is particularly proposed.
Disclosure of Invention
The first purpose of the invention is to provide a wild pineapple extract, which is mainly prepared by sequentially concentrating and spray drying a wild pineapple extract, and the wild pineapple extract has a good treatment effect on hyperuricemia.
The second purpose of the invention is to provide an application of the wild pineapple extract, and the wild pineapple extract can be widely applied to the preparation process of products for treating hyperuricemia.
The third purpose of the invention is to provide a medicine for treating hyperuricemia, which comprises the wild pineapple extract and a traditional Chinese medicine extract.
The fourth purpose of the invention is to provide a preparation method of the medicine for treating hyperuricemia.
In order to achieve the above purpose of the present invention, the following technical solutions are adopted:
the wild pineapple extract provided by the invention is mainly prepared by sequentially concentrating and spray drying a wild pineapple extracting solution;
the preparation method of the wild pineapple extracting solution comprises the following steps: firstly, pretreating fresh wild pineapple fruits to obtain wild pineapple powder; then, carrying out water extraction on the wild pineapple powder to obtain water extract and water extraction filter residue; then carrying out alcohol extraction on the water extraction filter residue to obtain an alcohol extract; and finally, uniformly mixing the water extract and the alcohol extract to obtain the wild pineapple extract.
Further, the method for preprocessing comprises the following steps: drying the fresh wild pineapple fruits, and then crushing into powder which is sieved by a 40-80-mesh sieve.
Further, in the water extraction process, the mass ratio of the wild pineapple powder to the water is 1: 3-10;
preferably, the temperature of the water extraction is 75-85 ℃, and the time is 1-2 h.
Further, the alcohol extraction solvent for alcohol extraction is one of methanol, ethyl acetate, petroleum ether or n-hexane, preferably ethanol;
more preferably, the alcohol extraction solvent is ethanol with the mass concentration of 80%;
preferably, in the alcohol extraction process, the mass ratio of the water extraction filter residue to the alcohol extraction solvent is 1: 3-10;
preferably, the alcohol extraction temperature is 55-65 ℃, and the time is 1-2 h.
Further, the concentration is evaporation concentration;
preferably, the evaporation concentration is performed by using a vacuum rotary evaporator;
preferably, the inlet temperature of the spray drying is 130-180 ℃, and the outlet temperature is 70-85 ℃.
The invention provides an application of the wild pineapple extract in preparing a product for treating hyperuricemia;
preferably, the product for treating hyperuricemia comprises a drug or a functional food.
The invention provides a medicine for treating hyperuricemia, which comprises the wild pineapple extract and a traditional Chinese medicine extract;
wherein the Chinese medicinal extract is mainly prepared from rhizoma Ligustici Chuanxiong, rhizoma Atractylodis, semen Persicae, Carthami flos, ramulus Cinnamomi, Glycyrrhrizae radix, Myrrha, radix Angelicae sinensis, Oletum Trogopterori, rhizoma Cyperi, Achyranthis radix, Lumbricus, Corni fructus, herba asari and radix Saposhnikoviae;
preferably, the traditional Chinese medicine extract comprises, by mass, 5-8 parts of ligusticum wallichii, 8-12 parts of rhizoma atractylodis, 6-12 parts of peach kernel, 6-12 parts of safflower, 5-8 parts of cassia twig, 5-8 parts of liquorice, 5-8 parts of myrrh, 6-12 parts of angelica, 6-8 parts of trogopterus dung, 3-5 parts of rhizoma cyperi, 6-12 parts of achyranthes bidentata, 5-8 parts of earthworm, 8-12 parts of dogwood, 3-5 parts of asarum and 8-12 parts of radix sileris.
Furthermore, the dosage form of the medicine is any one of pills, granules, powder, capsules or tablets.
The preparation method of the medicine for treating hyperuricemia provided by the invention comprises the following steps:
mixing the wild pineapple extract and the traditional Chinese medicine extract uniformly, and then crushing to prepare the medicine for treating hyperuricemia;
preferably, the preparation method of the traditional Chinese medicine extract comprises the following steps:
mixing rhizoma Ligustici Chuanxiong, rhizoma Atractylodis, semen Persicae, Carthami flos, ramulus Cinnamomi, Glycyrrhrizae radix, Myrrha, radix Angelicae sinensis, Oletum Trogopterori, rhizoma Cyperi, Achyranthis radix, Lumbricus, Corni fructus, herba asari and radix Saposhnikoviae to obtain material A, and sequentially extracting with water and ethanol; then combining the water extract and the alcohol extract to obtain a mixed solution A; and concentrating and spray drying the mixed solution A in sequence to obtain the traditional Chinese medicine extract.
Further, the mass ratio of the wild pineapple extract to the traditional Chinese medicine extract is 7-1: 3 to 5.
Compared with the prior art, the invention has the beneficial effects that:
the wild pineapple extract provided by the invention is mainly prepared by sequentially concentrating and spray drying a wild pineapple extracting solution; the preparation method of the wild pineapple extracting solution comprises the following steps: firstly, pretreating fresh wild pineapple fruits to obtain wild pineapple powder; then, carrying out water extraction on the wild pineapple powder to obtain water extract and water extraction filter residue; then carrying out alcohol extraction on the water extraction filter residue to obtain an alcohol extract; and finally, uniformly mixing the water extract and the alcohol extract to obtain the wild pineapple extract. Said wild pineapple is named also Pandanus trifoliate acanthopanax (L.) Parkins), Pandanus trifoliatus of Pandanus family, is a traditional cooking and medicinal material in south Ling area of China, takes root, fruit and fruit stone as medicines, has the functions of inducing sweat, relieving exterior syndrome, promoting qi circulation, relieving pain, calming liver, clearing heat, removing dampness and promoting urination, and is used for treating cold, fever, rheumatalgia, traumatic injury, liver fire headache, hepatitis, cirrhosis ascites, nephritic edema, urinary tract infection, conjunctivitis and other diseases. The wild pineapple extract prepared by the method has a good treatment effect on hyperuricemia, and effectively solves the problem of side effects of medicines caused by the fact that the existing traditional Chinese medicine preparation for treating hyperuricemia often contains medicines with severe cold and severe toxicity.
The wild pineapple extract provided by the invention can be widely applied to the preparation process of products for treating hyperuricemia.
The medicine for treating hyperuricemia provided by the invention comprises a wild pineapple extract and a traditional Chinese medicine extract; wherein the Chinese medicinal extract is mainly prepared from rhizoma Ligustici Chuanxiong, rhizoma Atractylodis, semen Persicae, Carthami flos, ramulus Cinnamomi, Glycyrrhrizae radix, Myrrha, radix Angelicae sinensis, Oletum Trogopterori, rhizoma Cyperi, Achyranthis radix, Lumbricus, Corni fructus, herba asari and radix Saposhnikoviae. The wild pineapple extract and the Chinese herbal medicines for preparing the traditional Chinese medicine extract are mild medicines, and the medicine for treating the hyperuricemia prepared from the raw materials effectively solves the problem of side effects of the existing traditional Chinese medicine preparation for treating the hyperuricemia, which is often caused by medicines with severe coldness and severe toxicity.
The preparation method of the medicine for treating hyperuricemia provided by the invention comprises the steps of uniformly mixing the wild pineapple extract and the traditional Chinese medicine extract, and then crushing to prepare the medicine for treating hyperuricemia. The preparation method has the advantages of simple processing technology and easy operation.
The pharmaceutical efficacy of the present invention is illustrated below:
case 1: when a certain plum is male and is 56 years old, the gout is suffered for 8 years, the knee joint is red, swollen and severe pain before the plum is taken, the measured value of uric acid is 580 mu mol/L, and the plum is bedridden. After the medicine is taken for 1 course of treatment, the pain is obviously relieved, the uric acid level is reduced to 480 mu mol/L, and after the medicine is taken for 5 courses of treatment, the uric acid level is rechecked to be normal and 360 mu mol/L, and the gout symptom is completely eliminated. The disease does not relapse after 1 year of follow-up visit.
Case 2: some Pan, male, 24 years old, bilateral toe joint red swelling and severe pain before taking medicine, uric acid measuring value 414 mu mol/L. After the medicine is taken for 1 treatment course, the uric acid value is 413 mu mol/L, the pain of the toes on both sides is obviously relieved, the uric acid calculus is reduced, after the medicine is taken for 15 treatment courses, the normal uric acid value is rechecked, the pain of the toes on both sides disappears, the uric acid calculus disappears, and the gout symptom is completely eliminated. The disease does not relapse after 1 year of follow-up visit.
Case 3: after taking the medicine for 1 treatment course, the swelling and pain symptoms of the finger joints are obviously relieved, the measured value of uric acid is normal and reduced to 392 mu mol/L, the medicine is continuously taken for 2 treatment courses, the uric acid value is examined to be normal, and the gout symptoms are completely eliminated. The disease does not relapse after 1 year of follow-up visit.
Case 4: after taking the medicine for 1 treatment course, the red swelling and pain of the knee joint are obviously relieved, the measured value of uric acid is reduced to 480 mu mol/L, after the medicine is continuously taken for 8 treatment courses, the measured value of uric acid is rechecked to be normal, and the gout symptom is completely eliminated. The disease does not relapse after 1 year of follow-up visit.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
According to one aspect of the invention, the wild pineapple extract is mainly prepared by sequentially concentrating and spray-drying wild pineapple extract;
the preparation method of the wild pineapple extracting solution comprises the following steps: firstly, pretreating fresh wild pineapple fruits to obtain wild pineapple powder; then, carrying out water extraction on the wild pineapple powder to obtain water extract and water extraction filter residue; then carrying out alcohol extraction on the water extraction filter residue to obtain an alcohol extract; and finally, uniformly mixing the water extract and the alcohol extract to obtain the wild pineapple extract.
The wild pineapple extract provided by the invention is mainly prepared by sequentially concentrating and spray drying a wild pineapple extracting solution; the preparation method of the wild pineapple extracting solution comprises the following steps: firstly, pretreating fresh wild pineapple fruits to obtain wild pineapple powder; then, carrying out water extraction on the wild pineapple powder to obtain water extract and water extraction filter residue; then carrying out alcohol extraction on the water extraction filter residue to obtain an alcohol extract; and finally, uniformly mixing the water extract and the alcohol extract to obtain the wild pineapple extract. Said wild pineapple is named also Pandanus trifoliate acanthopanax (L.) Parkins), Pandanus trifoliatus of Pandanus family, is a traditional cooking and medicinal material in south Ling area of China, takes root, fruit and fruit stone as medicines, has the functions of inducing sweat, relieving exterior syndrome, promoting qi circulation, relieving pain, calming liver, clearing heat, removing dampness and promoting urination, and is used for treating cold, fever, rheumatalgia, traumatic injury, liver fire headache, hepatitis, cirrhosis ascites, nephritic edema, urinary tract infection, conjunctivitis and other diseases. The wild pineapple extract prepared by the method has a good treatment effect on hyperuricemia, and effectively solves the problem of side effects of medicines caused by the fact that the existing traditional Chinese medicine preparation for treating hyperuricemia often contains medicines with severe cold and severe toxicity.
In a preferred embodiment of the present invention, the method of pre-treatment comprises: drying the fresh wild pineapple fruits, and then crushing into powder which is sieved by a 40-80-mesh sieve.
Preferably, the method of pre-treatment comprises the steps of: picking mature jackfruit, cleaning, cutting soft pulp, drying in a 60 ℃ blast drying oven, and airing hard seed parts in a ventilated place; subsequently, the pulp and the seeds were mixed and pulverized into powder passing through a 60 mesh sieve by a pulverizer.
In a preferred embodiment of the present invention, in the water extraction process, the weight ratio of the wild pineapple powder to the water is 1: 3-10;
preferably, the temperature of the water extraction is 75-85 ℃, and the time is 1-2 h.
In a preferred embodiment of the present invention, the alcohol extraction solvent for alcohol extraction is one of methanol, ethyl acetate, petroleum ether or n-hexane, preferably ethanol;
in the above preferred embodiment, the alcohol extraction solvent is ethanol with a mass concentration of 80%;
in the above preferred embodiment, in the alcohol extraction process, the mass ratio of the water extraction residue to the alcohol extraction solvent is 1: 3-10;
in the preferred embodiment, the alcohol extraction temperature is 55-65 ℃ and the time is 1-2 h.
In a preferred embodiment of the invention, the concentration is an evaporative concentration;
preferably, the evaporation concentration is performed by using a vacuum rotary evaporator;
in the preferred embodiment, the concentration by evaporation is performed by vacuum rotary evaporator at 50 ℃ until the content is about 80%.
In a preferred embodiment of the present invention, the inlet temperature of the spray drying is 130 to 180 ℃ and the outlet temperature is 70 to 85 ℃.
According to one aspect of the invention, the application of the wild pineapple extract in preparing a product for treating hyperuricemia;
the wild pineapple extract provided by the invention can be widely applied to the preparation process of products for treating hyperuricemia.
Preferably, the product for treating hyperuricemia comprises a drug or a functional food.
According to one aspect of the invention, the medicine for treating hyperuricemia comprises the above wild pineapple extract and a traditional Chinese medicine extract;
wherein the Chinese medicinal extract is mainly prepared from rhizoma Ligustici Chuanxiong, rhizoma Atractylodis, semen Persicae, Carthami flos, ramulus Cinnamomi, Glycyrrhrizae radix, Myrrha, radix Angelicae sinensis, Oletum Trogopterori, rhizoma Cyperi, Achyranthis radix, Lumbricus, Corni fructus, herba asari and radix Saposhnikoviae;
preferably, the traditional Chinese medicine extract comprises, by mass, 5-8 parts of ligusticum wallichii, 8-12 parts of rhizoma atractylodis, 6-12 parts of peach kernel, 6-12 parts of safflower, 5-8 parts of cassia twig, 5-8 parts of liquorice, 5-8 parts of myrrh, 6-12 parts of angelica, 6-8 parts of trogopterus dung, 3-5 parts of rhizoma cyperi, 6-12 parts of achyranthes bidentata, 5-8 parts of earthworm, 8-12 parts of dogwood, 3-5 parts of asarum and 8-12 parts of radix sileris.
The medicine for treating hyperuricemia provided by the invention comprises a wild pineapple extract and a traditional Chinese medicine extract; wherein the Chinese medicinal extract is mainly prepared from rhizoma Ligustici Chuanxiong, rhizoma Atractylodis, semen Persicae, Carthami flos, ramulus Cinnamomi, Glycyrrhrizae radix, Myrrha, radix Angelicae sinensis, Oletum Trogopterori, rhizoma Cyperi, Achyranthis radix, Lumbricus, Corni fructus, herba asari and radix Saposhnikoviae;
wherein, the rhizoma ligustici wallichii is pungent and warm, enters the liver, spleen and triple energizer meridians, promotes qi circulation, relieves stagnation, dispels wind-dryness and dampness, and activates blood circulation to stop pain; the rhizoma atractylodis is pungent, bitter and warm in nature, enters spleen, stomach and liver channels, dries dampness and strengthens spleen, and dispels wind and cold; the cassia twig, pungent, sweet and warm, enters the lung, heart and bladder channels, sweats and relieves muscles, warms and dredges the channels and collaterals, and assists yang and regulates qi; when entering liver, heart and spleen channels, it can tonify blood and activate blood; trogopterus dung is sweet and warm, and can promote qi circulation; the nutgrass galingale rhizome has sweet flavor and enters four meridians of lung, liver, spleen and stomach to release exterior and relieve pain; lumbricus has effects in clearing away heat, calming endogenous wind, dredging collaterals, and promoting urination; corni fructus has effects of nourishing, invigorating stomach, promoting urination, nourishing liver and kidney, and invigorating qi and blood; the asarum has the effects of relieving exterior syndrome, dispelling cold, expelling wind, relieving pain and dredging orifices; the Chinese medicinal herbs have bitter and pungent taste and warm property, and can dissipate blood stasis, relieve swelling and relieve pain; the achyranthes root is bitter, sweet, sour and neutral in nature and has the effects of entering liver and kidney channels, removing blood stasis and stimulating the menstrual flow, tonifying liver and kidney, strengthening muscles and bones, inducing diuresis and treating stranguria, and drawing blood downward; wind-proof, pungent, sweet and warm in flavor, has the actions of relieving exterior syndrome, inducing perspiration, dispelling wind and removing dampness. In the formula, peach kernel, safflower, angelica and rhizoma ligustici wallichii activate blood and remove stasis; myrrha, Oletum Trogopterori, and rhizoma Cyperi can promote circulation of qi and blood and relieve pain; achyranthes and cyathula root, earthworm dredge the channels and collaterals to benefit the joints; meanwhile, the atractylodes is matched with asarum and divaricate saposhnikovia root to expel wind, warm channel and dispel cold, dredge collaterals and relieve pain, and is good for treating various rheumatic arthralgia; licorice root, radix Glycyrrhizae coordinates the effects of the other drugs in the recipe.
In summary, the specific formula principle of the application is as follows: peach kernel and safflower are monarch drugs which can promote blood circulation, remove blood stasis and dredge qi and blood of the whole body; achyranthes root, earthworm, rhizoma atractylodis, asarum and divaricate saposhnikovia root are used for dispelling wind and removing dampness, and promoting blood circulation and removing meridian obstruction, and are used as assistant and adjuvant; ramulus Cinnamomi, Oletum Trogopterori, Myrrha, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, rhizoma Cyperi, and Corni fructus as adjuvant drugs for promoting blood circulation, dredging channels, promoting qi circulation, and relieving pain; licorice root, radix Glycyrrhizae coordinates the effects of the other drugs in the recipe. The medicine for treating hyperuricemia, which is prepared by the compatibility of the medicines and the wild pineapple extract, effectively solves the problem of side effects of the existing traditional Chinese medicine preparation for treating hyperuricemia, which is often caused by medicines with severe cold and toxic properties.
In a preferred embodiment of the present invention, the dosage form of the drug is any one of pills, granules, powder, capsules or tablets.
According to an aspect of the present invention, a preparation method of the above drug for treating hyperuricemia comprises the following steps:
mixing the wild pineapple extract and the traditional Chinese medicine extract uniformly, and then crushing to prepare the medicine for treating hyperuricemia;
the preparation method of the medicine for treating hyperuricemia provided by the invention comprises the steps of uniformly mixing the wild pineapple extract and the traditional Chinese medicine extract, and then crushing to prepare the medicine for treating hyperuricemia. The preparation method has the advantages of simple processing technology and easy operation.
In a preferred embodiment of the present invention, the preparation method of the herbal extract comprises the following steps:
mixing rhizoma Ligustici Chuanxiong, rhizoma Atractylodis, semen Persicae, Carthami flos, ramulus Cinnamomi, Glycyrrhrizae radix, Myrrha, radix Angelicae sinensis, Oletum Trogopterori, rhizoma Cyperi, Achyranthis radix, Lumbricus, Corni fructus, herba asari and radix Saposhnikoviae to obtain material A, and sequentially extracting with water and ethanol; then combining the water extract and the alcohol extract to obtain a mixed solution A; and concentrating and spray drying the mixed solution A in sequence to obtain the traditional Chinese medicine extract.
Preferably, the preparation method of the traditional Chinese medicine extract comprises the following steps:
mixing rhizoma Ligustici Chuanxiong, rhizoma Atractylodis, semen Persicae, Carthami flos, ramulus Cinnamomi, Glycyrrhrizae radix, Myrrha, radix Angelicae sinensis, Oletum Trogopterori, rhizoma Cyperi, Achyranthis radix, Lumbricus, Corni fructus, herba asari and radix Saposhnikoviae to obtain material A, adding cellulase and pectinase with the amount of 1% into material A, adding 5 times volume of pure water, stirring at 55 deg.C for enzymolysis for 2 hr, and filtering; adding 3-10 times volume of pure water into the above residue, extracting at 80 deg.C for 1 hr, filtering with 200 mesh filter cloth, adding 5-10 times volume of 40%, 60%, and 95% ethanol into the residue, respectively, extracting at 60 deg.C for 1 hr, and extracting at each concentration for 2 times; mixing the above extractive solutions, and concentrating at 50 deg.C with vacuum rotary evaporator to content of about 80%; and finally, spray drying the concentrated solution to obtain the traditional Chinese medicine extract.
More preferably, the inlet temperature of the spray drying is 130-180 ℃ and the outlet temperature is 70-85 ℃.
In a preferred embodiment of the invention, the mass ratio of the wild pineapple extract to the traditional Chinese medicine extract is 7-1: 3-5, preferably 2: 1.
the technical solution of the present invention will be further described with reference to the following examples.
Example 1
A medicine for treating hyperuricemia is prepared by the following steps:
(1) picking up ripe wild pineapple fruits, cleaning, cutting soft pulp, putting the soft pulp into a 60 ℃ forced air drying oven for drying, and airing hard seed parts in a ventilated place; mixing the pulp and the seeds, and crushing the mixture into powder which is sieved by a 60-mesh sieve by using a crusher;
(2) weighing wild pineapple powder, adding 3 times of pure water, extracting at 80 ℃ for 1 hour, filtering with 200-mesh filter cloth, adding 3 times of 80% ethanol in volume into filter residue, extracting at 60 ℃ for 1 hour, and extracting for 2 times; mixing the above extractive solutions, and concentrating at 50 deg.C with vacuum rotary evaporator to content of about 80%; subsequently, spray drying the concentrated solution to obtain a wild pineapple extract;
the temperature of the spray drying inlet is 130 ℃, and the temperature of the spray drying outlet is 70 ℃.
(3) Weighing the traditional Chinese medicine prescription, and crushing the traditional Chinese medicine prescription into powder which is sieved by a 60-mesh sieve by using a crusher.
The traditional Chinese medicine formula comprises but is not limited to the following components: 5 parts of ligusticum wallichii, 6 parts of rhizoma atractylodis, 6 parts of peach kernel, 6 parts of safflower, 5 parts of cassia twig, 5 parts of liquorice, 5 parts of myrrh, 6 parts of angelica, 6 parts of trogopterus dung, 3 parts of rhizoma cyperi, 6 parts of achyranthes root, 5 parts of earthworm, 8 parts of dogwood, 3 parts of asarum and 8 parts of divaricate saposhnikovia root.
(4) Adding equivalent cellulase and pectinase into the mixed powder of the traditional Chinese medicine formula, wherein the total amount of the cellulase and the pectinase is 1%, adding 5 times of pure water by volume, stirring at 55 ℃ for enzymolysis for 2 hours, and filtering; adding 3-10 times volume of pure water into the above residue, extracting at 80 deg.C for 1 hr, filtering with 200 mesh filter cloth, adding 5-10 times volume of 40%, 60%, and 95% ethanol into the residue, respectively, extracting at 60 deg.C for 1 hr, and extracting at each concentration for 2 times; mixing the above extractive solutions, and concentrating at 50 deg.C with vacuum rotary evaporator to content of about 80%; subsequently, spray drying the concentrated solution to obtain traditional Chinese medicine extract;
the temperature of the spray drying inlet is 130 ℃, and the temperature of the spray drying outlet is 70 ℃.
(5) Uniformly mixing the wild pineapple extract and the extract powder of the Chinese medicinal formula according to the mass ratio of 5: 4, and carrying out superfine grinding to obtain the medicament for treating hyperuricemia;
sterilizing the medicine for treating hyperuricemia, and encapsulating the medicine into capsules, wherein each capsule contains 2.0g of effective medicine, and the content of the effective medicine in each capsule is 0.6g, so that the medicine for treating hyperuricemia in the capsules is obtained.
Example 2
A medicine for treating hyperuricemia is prepared by the following steps:
(1) picking up ripe wild pineapple fruits, cleaning, cutting soft pulp, putting the soft pulp into a 60 ℃ forced air drying oven for drying, and airing hard seed parts in a ventilated place; mixing the pulp and the seeds, and crushing the mixture into powder which is sieved by a 60-mesh sieve by using a crusher;
(2) weighing wild pineapple powder, adding 10 times of pure water, extracting at 80 ℃ for 1h, filtering with 200-mesh filter cloth, adding 10 times of 80% ethanol, extracting at 60 ℃ for 1h, and extracting for 2 times; mixing the above extractive solutions, and concentrating at 50 deg.C with vacuum rotary evaporator to content of about 80%; subsequently, spray drying the concentrated solution to obtain a wild pineapple extract;
the temperature of the spray drying inlet is 180 ℃, and the temperature of the spray drying outlet is 85 ℃.
(3) Weighing the traditional Chinese medicine prescription, and crushing the traditional Chinese medicine prescription into powder which is sieved by a 60-mesh sieve by using a crusher.
The traditional Chinese medicine formula comprises but is not limited to the following components: 8 parts of ligusticum wallichii, 12 parts of rhizoma atractylodis, 12 parts of peach kernel, 12 parts of safflower, 8 parts of cassia twig, 8 parts of liquorice, 8 parts of myrrh, 12 parts of angelica, 8 parts of trogopterus dung, 5 parts of rhizoma cyperi, 12 parts of achyranthes root, 8 parts of earthworm, 12 parts of dogwood, 5 parts of asarum and 12 parts of divaricate saposhnikovia root.
(4) Adding equivalent cellulase and pectinase into the mixed powder of the traditional Chinese medicine formula, wherein the total amount of the cellulase and the pectinase is 1%, adding 5 times of pure water by volume, stirring at 55 ℃ for enzymolysis for 2 hours, and filtering; adding 3-10 times volume of pure water into the filter residue, extracting at 80 deg.C for 1 hr, filtering with 200 mesh filter cloth, adding 10 times volume of 40%, 60%, and 95% ethanol into the filter residue, respectively, extracting at 60 deg.C for 1 hr, and extracting at each concentration for 2 times; mixing the above extractive solutions, and concentrating at 50 deg.C with vacuum rotary evaporator to content of about 80%; subsequently, spray drying the concentrated solution to obtain traditional Chinese medicine extract;
the temperature of the spray drying inlet is 180 ℃, and the temperature of the spray drying outlet is 85 ℃.
(5) Uniformly mixing the wild pineapple extract and the extract powder of the traditional Chinese medicine formula according to the mass ratio of 1: 5, and carrying out superfine grinding to obtain the medicine for treating hyperuricemia;
sterilizing the medicine for treating hyperuricemia, and encapsulating the medicine into capsules, wherein each capsule contains 2.0g of effective medicine, and the content of the effective medicine in each capsule is 0.69g, so that the medicine for treating hyperuricemia in the capsules is obtained.
Example 3
A medicine for treating hyperuricemia is prepared by the following steps:
(1) picking up ripe wild pineapple fruits, cleaning, cutting soft pulp, putting the soft pulp into a 60 ℃ forced air drying oven for drying, and airing hard seed parts in a ventilated place; mixing the pulp and the seeds, and crushing the mixture into powder which is sieved by a 60-mesh sieve by using a crusher;
(2) weighing wild pineapple powder, adding 6 times of pure water, extracting at 80 ℃ for 1 hour, filtering with 200-mesh filter cloth, adding 6 times of 80% ethanol, extracting at 60 ℃ for 1 hour, and extracting for 2 times; mixing the above extractive solutions, and concentrating at 50 deg.C with vacuum rotary evaporator to content of about 80%; subsequently, spray drying the concentrated solution to obtain a wild pineapple extract;
the temperature of the spray drying inlet is 150 ℃, and the temperature of the spray drying outlet is 80 ℃.
(3) Weighing the traditional Chinese medicine prescription, and crushing the traditional Chinese medicine prescription into powder which is sieved by a 60-mesh sieve by using a crusher.
The traditional Chinese medicine formula comprises but is not limited to the following components: 8 parts of ligusticum wallichii, 10 parts of rhizoma atractylodis, 9 parts of peach kernel, 9 parts of safflower, 6 parts of cassia twig, 6 parts of liquorice, 6 parts of myrrh, 10 parts of angelica, 8 parts of trogopterus dung, 4 parts of rhizoma cyperi, 10 parts of radix achyranthis bidentatae, 6 parts of earthworm, 10 parts of dogwood, 4 parts of asarum and 10 parts of radix sileris.
(4) Adding equivalent cellulase and pectinase into the mixed powder of the traditional Chinese medicine formula, wherein the total amount of the cellulase and the pectinase is 1%, adding 5 times of pure water by volume, stirring at 55 ℃ for enzymolysis for 2 hours, and filtering; adding 6 times volume of pure water into the above residue, extracting at 80 deg.C for 1 hr, filtering with 200 mesh filter cloth, adding 5-10 times volume of 40%, 60%, and 95% ethanol into the residue, respectively, extracting at 60 deg.C for 1 hr, and extracting at each concentration for 2 times; mixing the above extractive solutions, and concentrating at 50 deg.C with vacuum rotary evaporator to content of about 80%; subsequently, spray drying the concentrated solution to obtain traditional Chinese medicine extract;
the temperature of the spray drying inlet is 150 ℃, and the temperature of the spray drying outlet is 80 ℃.
(5) Uniformly mixing the wild pineapple extract and the extract powder of the Chinese medicinal formula according to the mass ratio of 7: 3, and carrying out superfine grinding to obtain the medicament for treating hyperuricemia;
sterilizing the medicine for treating hyperuricemia, and encapsulating the medicine into capsules, wherein each capsule contains 2.0g of effective medicine, and the content of the effective medicine in each capsule is 0.65g, so that the medicine for treating hyperuricemia in capsules is obtained.
Experimental example 1
In the experimental example, the cases are selected from 2018-2019, and 58 gout patients are subjected to clinical observation and treatment, wherein 42 males and 16 females are in the experimental population, and the age of the experimental population is 24-68 years.
1. The treatment method comprises the following steps: the traditional Chinese medicine capsule for treating gout prepared in the embodiment 3 is taken 2 times after meals every day, 2 granules are taken each time, 1 course of treatment is taken in 5 days, 1-5 courses of treatment are taken, and the diet is light during the taking period.
2. Clinical symptoms: only fluctuating or persistent hyperuricemia occurs, but gout has not yet occurred. The time from the rise of blood uric acid to the appearance of symptoms can reach several years, and some symptoms can not appear in life. The first attack involves a single joint, the unilateral first metatarsophalangeal joint is common, the joint is extremely painful when the attack occurs, the peak is reached within hours, and the affected joint is red, swollen, hot, painful and dysfunctional. Can be accompanied with hyperuricemia, but the blood uric acid level is normal at part of acute attack. Urate crystals are found in synovial fluid or tophus and may be accompanied by fever. It is commonly seen in middle-aged and elderly men, and gradually younger, with family history of gout. It is often induced by fatigue, overeating, eating high purine food, drinking alcohol and wind-cold.
3. Treatment criteria were:
and (3) curing: the joint pain and swelling disappear, the uric acid is normal (<420 mu mol/L), the uric acid calculus disappears, and the disease does not relapse within 3 months.
The effect is shown: the joint pain and swelling are reduced, the treatment can still be relieved after the joint pain and swelling recur within 3 months, and the blood uric acid is reduced.
And (4) invalidation: joint pain, swelling and the like have no obvious changes, and blood uric acid has no changes.
4. Clinical results:
55 patients with gout (94.83 percent) and 3 patients with significant effect (5.17 percent) are clinically cured in 58 tested gout patients, and the total effective rate is 100 percent.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (10)
1. A wild pineapple extract is characterized in that the wild pineapple extract is mainly prepared by sequentially concentrating and spray drying a wild pineapple extracting solution;
the preparation method of the wild pineapple extracting solution comprises the following steps: firstly, pretreating fresh wild pineapple fruits to obtain wild pineapple powder; then, carrying out water extraction on the wild pineapple powder to obtain water extract and water extraction filter residue; then carrying out alcohol extraction on the water extraction filter residue to obtain an alcohol extract; and finally, uniformly mixing the water extract and the alcohol extract to obtain the wild pineapple extract.
2. The extract of jackfruit of claim 1, characterized in that the method of pre-treatment comprises: drying the fresh wild pineapple fruits, and then crushing into powder which is sieved by a 40-80-mesh sieve.
3. The extract of jackfruit of claim 1, wherein the mass ratio of jackfruit powder to water in the water extraction process is 1: 3-10;
preferably, the temperature of the water extraction is 75-85 ℃, and the time is 1-2 h.
4. The jackfruit extract as claimed in claim 1, wherein the alcohol extraction solvent of alcohol extraction is one of methanol, ethyl acetate, petroleum ether or n-hexane, preferably ethanol;
more preferably, the alcohol extraction solvent is ethanol with the mass concentration of 80%;
preferably, in the alcohol extraction process, the mass ratio of the water extraction filter residue to the alcohol extraction solvent is 1: 3-10;
preferably, the alcohol extraction temperature is 55-65 ℃, and the time is 1-2 h.
5. The extract of jackfruit of claim 1, wherein the concentration is an evaporative concentration;
preferably, the evaporation concentration is performed by using a vacuum rotary evaporator;
preferably, the inlet temperature of the spray drying is 130-180 ℃, and the outlet temperature is 70-85 ℃.
6. Use of an extract of Ananas comosus according to any one of claims 1 to 5 in the preparation of a product for the treatment of hyperuricemia;
preferably, the product for treating hyperuricemia comprises a drug or a functional food.
7. A medicament for treating hyperuricemia, which comprises the wild pineapple extract as claimed in any one of claims 1 to 5 and a Chinese medicinal extract;
wherein the Chinese medicinal extract is mainly prepared from rhizoma Ligustici Chuanxiong, rhizoma Atractylodis, semen Persicae, Carthami flos, ramulus Cinnamomi, Glycyrrhrizae radix, Myrrha, radix Angelicae sinensis, Oletum Trogopterori, rhizoma Cyperi, Achyranthis radix, Lumbricus, Corni fructus, herba asari and radix Saposhnikoviae;
preferably, the traditional Chinese medicine extract comprises, by mass, 5-8 parts of ligusticum wallichii, 8-12 parts of rhizoma atractylodis, 6-12 parts of peach kernel, 6-12 parts of safflower, 5-8 parts of cassia twig, 5-8 parts of liquorice, 5-8 parts of myrrh, 6-12 parts of angelica, 6-8 parts of trogopterus dung, 3-5 parts of rhizoma cyperi, 6-12 parts of achyranthes bidentata, 5-8 parts of earthworm, 8-12 parts of dogwood, 3-5 parts of asarum and 8-12 parts of radix sileris.
8. The drug for treating hyperuricemia according to claim 7, wherein the drug is in the form of any one of a pill, a granule, a powder, a capsule, and a tablet.
9. The method for preparing a drug for treating hyperuricemia according to claim 7 or 8, wherein the preparation method comprises the following steps:
mixing the wild pineapple extract and the traditional Chinese medicine extract uniformly, and then crushing to prepare the medicine for treating hyperuricemia;
preferably, the preparation method of the traditional Chinese medicine extract comprises the following steps:
mixing rhizoma Ligustici Chuanxiong, rhizoma Atractylodis, semen Persicae, Carthami flos, ramulus Cinnamomi, Glycyrrhrizae radix, Myrrha, radix Angelicae sinensis, Oletum Trogopterori, rhizoma Cyperi, Achyranthis radix, Lumbricus, Corni fructus, herba asari and radix Saposhnikoviae to obtain material A, and sequentially extracting with water and ethanol; then combining the water extract and the alcohol extract to obtain a mixed solution A; and concentrating and spray drying the mixed solution A in sequence to obtain the traditional Chinese medicine extract.
10. The preparation method of the medicine for treating hyperuricemia according to claim 9, wherein the mass ratio of the wild pineapple extract to the traditional Chinese medicine extract is 7-1: 3 to 5.
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| CN110755489A (en) * | 2019-11-01 | 2020-02-07 | 李江山 | Traditional Chinese medicine for treating gout and preparation method thereof |
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| CN105617008A (en) * | 2016-03-30 | 2016-06-01 | 岳永彬 | Traditional Chinese medicine for treating acute gouty arthritis and preparation method thereof |
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