CN105998512A - Pharmaceutical composition for the treatment of femoral shaft fracture and preparation method thereof - Google Patents

Pharmaceutical composition for the treatment of femoral shaft fracture and preparation method thereof Download PDF

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Publication number
CN105998512A
CN105998512A CN201610384922.6A CN201610384922A CN105998512A CN 105998512 A CN105998512 A CN 105998512A CN 201610384922 A CN201610384922 A CN 201610384922A CN 105998512 A CN105998512 A CN 105998512A
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weight portion
pharmaceutical composition
herba
radix
fracture
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CN201610384922.6A
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Chinese (zh)
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姜文升
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Yantai Minwang Electromechanical Technology Co Ltd
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Yantai Minwang Electromechanical Technology Co Ltd
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Priority to CN201610384922.6A priority Critical patent/CN105998512A/en
Publication of CN105998512A publication Critical patent/CN105998512A/en
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
    • A61K36/8905—Cyperus (flatsedge)
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    • A61K36/11—Pteridophyta or Filicophyta (ferns)
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Abstract

The invention discloses a pharmaceutical composition for the treatment of femoral shaft fracture and a preparation method thereof. The pharmaceutical composition is made from the following raw materials: Rosa multiflora, juice of oriental grape, jujube, Cyperus Michelianus, delavay pararuellia herb, Tanarius major, violet Herba, pseudo-ginseng, herba taching, licorice, elderberry, the root of red-rooted salvia, scabrid smallhooked hedyotis herb, Gaultheria pyroloides, Ceylon houndstongue leaf or root-bark, chun spicebush root, rhizoma polygoni suffulti, Adenophora trachelioides, Thlaspi arvense, cimicifugae foetidae, one strike decoction, medlar and sivery aleuritopteris herb. The invention has the beneficial effects that the pharmaceutical composition has the effects of invigorating qi, generating muscle, and promoting blood circulation to remove meridian obstruction, can remove blood stasis, generate new muscle, repair bone, promote the formation of bone cells and recovery of peripheral nerve and muscle; and the efficacy directly reaches the lesions. The invention has the advantages of simple production process, little side or toxic effects, low cost, no resistance and no recurrence.

Description

A kind of pharmaceutical composition treating fracture of shaft of femur and preparation method
Technical field
The present invention relates to technical field of medicine, particularly relate to a kind of pharmaceutical composition controlling fracture of shaft of femur and preparation method.
Background technology
Femur is tubular bone the longest in human body.Femoral shaft include under tuberosity 2～5 centimetres to condyle of femur the backbone of 2～5 centimetres.Femoral shaft is surrounded by three groups of muscle.Muscular due to thigh, has dislocation after fracture and overlapping more.Fracture far-end often has the tendency inwardly receiving displacement, the fracture of para-position, normal outwardly convex tendency, this displacement and angulation tendency, it should be noted that correct and prevent in fractures.Under femur during 1/3 fracture, owing to blood vessel is positioned at the rear of Fracture of femur, and remote broken ends of fractured bone Chang Xianghou angulation of fracturing, therefore easily stab the artery and vein at this.
The cause of disease: mostly be caused by powerful direct violence, also have person caused by a small amount of indirect violence.
Clinical manifestation:
Fracture of shaft of femur is many because of caused by violence, therefore it should be noted that systemic conditions and the damage of adjacent regions.
1. general manifestation: fracture of shaft of femur is many to be caused due to serious wound, and amount of bleeding is up to 1000～1500 milliliters.As being opening or comminuted fracture, amount of bleeding may be bigger, and patient can be with the performance of the hemorrhagic shock such as blood pressure drops, pale complexion；As merged the damage of other position internal organs, the performance of shock may become apparent from.Therefore, for this type of situation, should first measure blood pressure tight dynamically observation, and note peripheral blood circulation.
2. topical manifestations: can have the general character symptom of fracture, limited and longitudinal percussion pain or bony crepitus including pain, local swelling, angulation deformity, abnormal movement, limb function.With the exception of this, should tentatively judge the position of fracture according to the outside orthodontic condition of limbs, particularly during Lower Distal Extremities external rotatory position, notice that performance with the hip injury such as intertrochanteric fracture is not obscured mutually, there may come a time when it is that two kinds of damages exist simultaneously.As being associated with nerve, blood vessel injury, dorsal artery of foot can be slight without beating or beating, and hindering limb has the performance of abnormal circulation, superficial sensibility exception or far-end can be had to be arranged muscle muscular strength abnormal.
Classification:
The sorting technique that in Switzerland, fixing association (AO/ASIF) is formulated is practical.Fracture of shaft of femur can be divided into A, B, C tri-class, all kinds of is divided into again 1,2,3 three hypotypes.
The auxiliary examination method of primary disease is mainly x-ray inspection: for serious case, and x-ray inspection can find the degree of impairment of fracture in early days；And slight fracture, or the fracture (as stress type is fractured) of specific type, x-ray inspection can have a following performance: x-ray sign without exception in early days, after 2～4 weeks, visible periosteal reaction and/or callus generate, in parallel shape or mound shape, the low-density gap of visible parallel shape between hypertrophy periosteum and/or callus and cortical bone, minority is walking crosswise compact zone and/or the serated fracture line walked crosswise seen from the mid-plane bump pad of hypertrophy periosteum and/or callus, As time goes on, hypertrophy periosteum develops into callus completely, density is gradually increased, and low-density gap disappears between cortex, divide a word with a hyphen at the end of a line mutually with cortical bone in two ends up and down, it is equal to cortical bone to density when repairing completely, x-ray shows as limiting to cortical bone and thickens.
Primary disease such as complicated with acute is fractured, and proximal segment edge visible hyperplasia periosteum and/or callus at fracture rupture the most therewith, can be other with old fracture in conjunction with medical history, symptom etc..
Diagnosis
Trauma history, thigh local swelling deformation is all serious, and Lower limb shortening has obvious abnormal movement and bony crepitus when moving.Answer conventional determining blood pressure, P&R, determine with or without shock or other systemic complications and important organ combined injury；The color of toes to be gone through, temperature and stretch bend activity, to determine whether there is Major Vessels and (or) nerve injury.A few patients can merge fracture of femoral neck or dislocation of hip joint, does not omit when health check-up.Take the photograph the feature of position, type and displacement that x-ray anterioposterior and lateral film can clearly be fractured, as the foundation for the treatment of.
Complication
Being subjected to powerful violence infringement during due to fracture, fracture of shaft of femur is often accompanied by whole body panels with multiple site damage, or the damage with body important organ.With regard to fracture of shaft of femur itself, owing to there being important neural blood vessel traveling inside femoral shaft, fracture when occurring or inappropriate carrying after wound, sharp-pointed fracture end punctures vascularization massive hemorrhage, hemorrhage plus fracture itself, the internal hemorrhage amount of adult can reach 500-1500 milliliter, occurs hemorrhagic shock time serious.Under femur, 1/3 fractures, and fracture segment is toppled over backward by the tractive of gastrocnemius, and distal fracture end can oppress or stimulate tremulous pulse, vein and sciatic nerve.The damage of blood vessel is likely to result in the blood supply obstacle of far-end of limb, even limb necrosis.Sciatic impaired performance is that drop foot, toes stretch the classical symptom signs such as in the wrong unable and foot sensory disturbance.
Except in the case of above complication, primary disease can be with the serious complication such as accompanying infection and bone does not connect.
Affect fracture factor: the healing of fracture is completed by osteoblast, so almost all of endogenous and extrinsic factor all may have influence on the metabolism of cell, promote and postpone the healing of fracture.(1) local factor: 1. degree of injury: periosteum injury is serious, and the healing rate of fracture is the slowest.2. the type of fracture: what fracture was involved is cortical bone or spongy bone, the speed of its healing has obvious difference.Allograft with That of Cancellous is very fast, and the agglutination of cortical bone is complicated, many by external influence factors.3. fixing situation: fixing is union of fracture essential condition.4. fracture the contact in face: owing to reduction is bad or fixing improper, making fracture end still have angulation, shift, separate, these all easily cause nonunion or slow concrescence.The most special violence: when fracture by special violence as caused by high-tension electricity or bullet time, cause nonunion or slow concrescence.Bear a heavy burden the most too early: irrational early ambulant, make newly formed fiber callus or osseous callus tear fracture cause nonunion or slow concrescence.7. broken ends of fractured bone blood supply is not enough: the regeneration of tissue, needs enough blood supplys.8. infect: but as long as efficiently controlling infection, fracture is to heal.9. pathological fracture: the pathological fracture that osteopathia and tumor cause is on the premise of handling local lesion well, and fracture can heal, but malignant tumor often prognosis mala.10. intra-articular fracture: owing to containing plasmin in knuckle synovia after intra-articular fracture, it can make fracture dissolution of blood clot in early days, postpones the first phase repair process of fracture, thus healing is slowly.(2) systemic factor: include age, health condition, the impact of hormone, move and the local stress state fractured and the function of current etc..
The malunion of fracture, delayed union, disunion: the malunion that () fractures: malunion of fracture refer to fracture site overlapping, rotate, connect under angulation state and the person that causes limbs disturbance.(2) fracture delayed union and disunion: limbs each portion fracture is through treatment, if after fracture the average healing is in the past, when not yet forming bony union, clinical examination still have hinder pain at limb, fracture local still has tenderness and x-ray to take the photograph sheet inspection to see that fracture line is the most clear, but fracture end there is no hardening phenomenon person, is fracture delayed union.
The method for the treatment of fracture of shaft of femur mainly has non-operative treatment treatment and operative treatment at present, non-operative treatment is also referred to as expectant treatment, conventional method has: various Chinese patent medicines, Western medicine Drug therapy, traction therapeutic, the treatment of exter-nal fixer, acupuncture and moxibustion therapy etc., although can be good at relief of symptoms, but therapeutic effect is the most undesirable, there is treatment time long, weak curative effect, somewhat expensive and have the defects such as side effect.
Western medical treatment fracture of shaft of femur, in recent years, due to the improvement of internal fixation device, the raising of surgical technic and people's change to fractures idea, fracture of shaft of femur now more tends to operative treatment.Fracture operation is treated, except must from fracture position, type, the degree of soft tissue injury, with or without merging outside the factor such as systemic conditions injuring patient considers, also need to select according to two principles: one is intended to the internal fixation material of sufficient intensity, make fixing after can early functional exercise and there is internal fixation apparatus fracture before being unlikely to union of fracture and lost efficacy；Two is Wicresoft to be advocated in fracture fixation method, and the destruction and the internal fixation apparatus that reduce fracture local blood fortune should not have stress concentrate and meet biological fixation principle, to promote union of fracture as far as possible.The medicament categories limitation for the treatment of fracture of shaft of femur, it is impossible to meet the demand of clinic auxiliary treatment.It is badly in need of a kind of active drug that can treat fracture of shaft of femur at present, meets the demand of clinical auxiliary treatment.
Summary of the invention
The technical problem to be solved is, it is provided that a kind of pharmaceutical composition treating fracture of shaft of femur and preparation method, has QI invigorating granulation promoting, effect of promoting blood circulation to remove obstruction in the collateral, can " blood stasis dispelling, tissue regeneration promoting, bone and ", promote the generation of osteocyte, and the recovery of N&M about, drug effect is gone directly focus, and processing technology is easy, there is toxic and side effects little, with low cost, it is not likely to produce drug resistance, the advantage of difficulty in relapse after healing.
For solving above-mentioned technical problem, the present invention provides a kind of pharmaceutical composition treating fracture of shaft of femur, wherein, described pharmaceutical composition is made up of following raw medicinal material: white residual flower, juice of Lobed Kudzuvine, Fructus Jujubae, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), Herb Pararuelliae delavayanae, Lignum Dalbergiae Odoriferae, Climbing Viloet Herb, Radix Notoginseng, Folium Isatidis, Radix Glycyrrhizae, Ramulus Sambuci Williamsii, Radix Salviae Miltiorrhizae, Herba Hedyotis scabridae, Gaultheria, Receptaculum fici Henryi, Cortex cynoglossi zeylanici radicis, Radix Linderae Chunii, RHIZOMA POLYGONI SUFFULTI, shepherd's purse, Xi, Rhizoma Cimicifugae, Herba Senecionis Dianthui, Fructus Lycii and Aleuritopteris argentea (Gmel.) Fee.
nullDescribed pharmaceutical composition is made up of the raw medicinal material of following parts by weight: white residual flower 10-20 weight portion、Juice of Lobed Kudzuvine 12-22 weight portion、Fructus Jujubae 15-45 weight portion、Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 13-33 weight portion、Herb Pararuelliae delavayanae 14-28 weight portion、Lignum Dalbergiae Odoriferae 12-22 weight portion、Climbing Viloet Herb 15-35 weight portion、Radix Notoginseng 14-28 weight portion、Folium Isatidis 15-25 weight portion、Radix Glycyrrhizae 10-40 weight portion、Ramulus Sambuci Williamsii 14-32 weight portion、Radix Salviae Miltiorrhizae 15-25 weight portion、Herba Hedyotis scabridae 11-21 weight portion、Gaultheria 13-33 weight portion、Receptaculum fici Henryi 10-30 weight portion、Cortex cynoglossi zeylanici radicis 15-25 weight portion、Radix Linderae Chunii 12-32 weight portion、RHIZOMA POLYGONI SUFFULTI 14-28 weight portion、Shepherd's purse 13-33 weight portion、Xi 11-21 weight portion、Rhizoma Cimicifugae 10-30 weight portion、Herba Senecionis Dianthui 15-35 weight portion、Fructus Lycii 10-20 weight portion and Aleuritopteris argentea (Gmel.) Fee 15-32 weight portion.
nullDescribed pharmaceutical composition is made up of the raw medicinal material of following parts by weight: white residual flower 12-20 weight portion、Juice of Lobed Kudzuvine 14-20 weight portion、Fructus Jujubae 15-45 weight portion、Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 15-30 weight portion、Herb Pararuelliae delavayanae 15-28 weight portion、Lignum Dalbergiae Odoriferae 12-22 weight portion、Climbing Viloet Herb 15-35 weight portion、Radix Notoginseng 14-28 weight portion、Folium Isatidis 15-25 weight portion、Radix Glycyrrhizae 10-40 weight portion、Ramulus Sambuci Williamsii 15-30 weight portion、Radix Salviae Miltiorrhizae 15-25 weight portion、Herba Hedyotis scabridae 12-20 weight portion、Gaultheria 13-33 weight portion、Receptaculum fici Henryi 10-30 weight portion、Cortex cynoglossi zeylanici radicis 15-25 weight portion、Radix Linderae Chunii 14-30 weight portion、RHIZOMA POLYGONI SUFFULTI 14-28 weight portion、Shepherd's purse 15-32 weight portion、Xi 12-20 weight portion、Rhizoma Cimicifugae 10-30 weight portion、Herba Senecionis Dianthui 15-35 weight portion、Fructus Lycii 10-20 weight portion and Aleuritopteris argentea (Gmel.) Fee 15-30 weight portion.
Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: white residual flower 14 weight portion, juice of Lobed Kudzuvine 15 weight portion, Fructus Jujubae 35 weight portion, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 25 weight portion, Herb Pararuelliae delavayanae 22 weight portion, Lignum Dalbergiae Odoriferae 15 weight portion, Climbing Viloet Herb 32 weight portion, Radix Notoginseng 20 weight portion, Folium Isatidis 17 weight portion, Radix Glycyrrhizae 40 weight portion, Ramulus Sambuci Williamsii 25 weight portion, Radix Salviae Miltiorrhizae 22 weight portion, Herba Hedyotis scabridae 14 weight portion, Gaultheria 33 weight portion, Receptaculum fici Henryi 20 weight portion, Cortex cynoglossi zeylanici radicis 21 weight portion, Radix Linderae Chunii 30 weight portion, RHIZOMA POLYGONI SUFFULTI 22 weight portion, shepherd's purse 32 weight portion, Xi 12 weight portion, Rhizoma Cimicifugae 20 weight portion, Herba Senecionis Dianthui 32 weight portion, Fructus Lycii 15 weight portion and Aleuritopteris argentea (Gmel.) Fee 20 weight portion.
Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: white residual flower 18 weight portion, juice of Lobed Kudzuvine 20 weight portion, Fructus Jujubae 40 weight portion, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 30 weight portion, Herb Pararuelliae delavayanae 24 weight portion, Lignum Dalbergiae Odoriferae 21 weight portion, Climbing Viloet Herb 32 weight portion, Radix Notoginseng 24 weight portion, Folium Isatidis 15 weight portion, Radix Glycyrrhizae 30 weight portion, Ramulus Sambuci Williamsii 25 weight portion, Radix Salviae Miltiorrhizae 19 weight portion, Herba Hedyotis scabridae 16 weight portion, Gaultheria 32 weight portion, Receptaculum fici Henryi 20 weight portion, Cortex cynoglossi zeylanici radicis 22 weight portion, Radix Linderae Chunii 30 weight portion, RHIZOMA POLYGONI SUFFULTI 26 weight portion, shepherd's purse 31 weight portion, Xi 13 weight portion, Rhizoma Cimicifugae 25 weight portion, Herba Senecionis Dianthui 33 weight portion, Fructus Lycii 15 weight portion and Aleuritopteris argentea (Gmel.) Fee 30 weight portion.
Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: white residual flower 16 weight portion, juice of Lobed Kudzuvine 17 weight portion, Fructus Jujubae 45 weight portion, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 20 weight portion, Herb Pararuelliae delavayanae 15 weight portion, Lignum Dalbergiae Odoriferae 17 weight portion, Climbing Viloet Herb 33 weight portion, Radix Notoginseng 22 weight portion, Folium Isatidis 18 weight portion, Radix Glycyrrhizae 30 weight portion, Ramulus Sambuci Williamsii 25 weight portion, Radix Salviae Miltiorrhizae 19 weight portion, Herba Hedyotis scabridae 12 weight portion, Gaultheria 31 weight portion, Receptaculum fici Henryi 20 weight portion, Cortex cynoglossi zeylanici radicis 17 weight portion, Radix Linderae Chunii 30 weight portion, RHIZOMA POLYGONI SUFFULTI 21 weight portion, shepherd's purse 30 weight portion, Xi 18 weight portion, Rhizoma Cimicifugae 23 weight portion, Herba Senecionis Dianthui 32 weight portion, Fructus Lycii 15 weight portion and Aleuritopteris argentea (Gmel.) Fee 28 weight portion.
When the dosage form of described pharmaceutical composition is paster agent, its preparation method comprises the following steps:
The first step: Herba Hedyotis scabridae, Gaultheria, Receptaculum fici Henryi, Cortex cynoglossi zeylanici radicis, Radix Linderae Chunii, RHIZOMA POLYGONI SUFFULTI, shepherd's purse and Xi are mixed in described ratio, soak with ethanol with the determining alcohol 85%～95% of 3～5 times of the mixture quality relative to acquisition, extract after being heated to reflux 2～4 hours, filter, obtain the first filtrate；By filtering residue again by the soak with ethanol of the determining alcohol 85%～95% relative to 1～2 times of mixture quality obtained, extract after being heated to reflux 1～2 hour, filter, obtain the second filtrate；Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first with deionized water or the distilled water eluting of 5 times of resin column volumes, it is 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol elution, concentrating under reduced pressure removes ethanol, is dried and is ground into powder；
Second step, Rhizoma Cimicifugae, Herba Senecionis Dianthui, Fructus Lycii and Aleuritopteris argentea (Gmel.) Fee are mixed in described ratio, the alcohol heating reflux adding the determining alcohol 85%～95% relative to 2～4 times of mixture quality obtained extracts 1～2 time, extracting solution merges, it is centrifuged remove impurity with tube centrifuge, when extracting solution after remove impurity is evaporated under conditions of 60 DEG C～70 DEG C 60 DEG C, relative density is the mastic of 1.20～1.23, and the mastic spray dryer after concentrating is dried to powder；
3rd step, is mixed surplus stock medical material in described ratio, adds the water soaking relative to 2～4 times of mixture quality obtained, and heating decocts 2～4 hours, filters；By filtering residue again with the water soaking of 1～2 times of the mixture quality relative to acquisition, heating decoction 1～2 hour, filter；Merging the filtrate of twice, concentrating under reduced pressure removes moisture, is dried and is ground into powder；
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the rubber relative to 1～2 times of described mixture of powders quality sum, the Colophonium of 1～2 times, mixing, make coating, carry out being coated with cream, cut off, lid lining, section, i.e. obtain described paster agent.
When the dosage form of described pharmaceutical composition is granule, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 85%～95% relative to mixture 4～8 times, it is heated to boiling reflux 3～5 hours, filter, use percolation with per minute 1～2ml speed slowly percolation, collect percolate, when being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa, relative density is the mastic of 1.04～1.10, it is spray-dried, the inlet temperature 160 of spray dryer～175 DEG C, leaving air temp 80～85 DEG C, be ground into powder subsequently, make dried cream powder；
Second step, adds relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times and the dextrin of 0.1～0.2 times in the dried cream powder obtained, makes granule, is dried in 40～50 DEG C, it is thus achieved that granule.
When the dosage form of described pharmaceutical composition is liniment, its preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, further pulverizes, crosses 100 mesh sieves, enables and is at least up to 40% by the fine powder amount of 100 mesh sieves, collects and obtains fine powder a by the fine powder of 100 mesh sieves；
Step 2: the coarse powder that will not pass through 100 mesh sieves puts into multi-function extractor extraction twice, adds weight portion 8-10 times amount soak by water 1-3 hour for the first time, and second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate；The heating of gained filtrate is concentrated into pasty state, and after putting into the drying of 80 DEG C of baking oven, room temperature cools down, and grinds to form fine powder b；
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
The invention has the beneficial effects as follows: the pharmaceutical composition of the present invention has QI invigorating granulation promoting, effect of promoting blood circulation to remove obstruction in the collateral, can " blood stasis dispelling, tissue regeneration promoting, bone and ", promote the generation of osteocyte, and the recovery of N&M about, drug effect is gone directly focus, and processing technology is easy, there is toxic and side effects little, with low cost, it is not likely to produce drug resistance, the advantage of difficulty in relapse after healing.
Detailed description of the invention
The invention provides a kind of pharmaceutical composition treating fracture of shaft of femur, wherein, it is made up of following raw medicinal material: white residual flower, juice of Lobed Kudzuvine, Fructus Jujubae, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), Herb Pararuelliae delavayanae, Lignum Dalbergiae Odoriferae, Climbing Viloet Herb, Radix Notoginseng, Folium Isatidis, Radix Glycyrrhizae, Ramulus Sambuci Williamsii, Radix Salviae Miltiorrhizae, Herba Hedyotis scabridae, Gaultheria, Receptaculum fici Henryi, Cortex cynoglossi zeylanici radicis, Radix Linderae Chunii, RHIZOMA POLYGONI SUFFULTI, shepherd's purse, Xi, Rhizoma Cimicifugae, Herba Senecionis Dianthui, Fructus Lycii and Aleuritopteris argentea (Gmel.) Fee.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Climbing Viloet Herb: another name: white Viola grypoceras A. Gray, Rhizoma Bergeniae scopulosae, wild Chinese cabbage, Herba Violae Serpentis, Fructus Trichosanthis Cucumeroidis grass, Fructus Cucumidis sativi grass, Matteuccia struthiopteri, Fructus Cucumidis sativi dish, silver teaspoon, stone Chinese cabbage, green snow.Source: Violaceae Viola plant Herba Violae Diffusae Viola diffusa Ging., with all herbal medicine.Spring Mo or autumn end gather herb, dry.Nature and flavor: bitter, micro-pungent, cold.Cure mainly: heat-clearing and toxic substances removing, detumescence and apocenosis.For hepatitis, pertussis, conjunctival congestion and swelling pain；Acute mastitis, furuncle, carbuncle furuncle, herpes zoster, venom, traumatic injury are controlled in external.
Xi: another name: Herba Patriniae, Thalaspi arvense L..Source: Cruciferae Xi platymiscium Xi Thlaspi arvense L., is used as medicine with herb and seed.Spring and summer gathers herb, dries；Autumn in summer fruit picking branch, dries, lays seed.Nature and flavor: herb: bitter, sweet, flat.Seed: pungent, bitter, tepor.Cure mainly: herb: heat-clearing and toxic substances removing, inducing diuresis and reducing edema, and middle appetizing.For appendicitis, lung abscess, carbuncle furuncle and phyma poison, erysipelas, endometritis, leucorrhea, nephritis, cirrhotic ascites, infantile dyspepsia.Seed: expelling wind and removing dampness, and stomach and alleviating pain.For rheumatic arthritis, lumbago, acute conjunctivitis, stomachache, hepatitis.
Juice of Lobed Kudzuvine: source: supplement to the Herbal.Source: for the rattan juice of vitaceae Pueraria lobota.Nature and flavor: 1. " not Lu ": " nontoxic." 2. Cui Yu pick " cuisine canon ": " sweet in the mouth is flat, little cold." cure mainly: tonifying five ZANG-organs, reuniting the fractured tendons and bones, QI invigorating, quench the thirst.1. " not Lu ": " main tonifying five ZANG-organs, QI invigorating, reuniting the fractured tendons and bones, long muscle, go all numbness.The tonifying five ZANG-organs of " 2. Cui Yu stannum " cuisine canon ": " food, boils with Rhizoma Dioscoreae as powder make medicated porridge food, main hiccup with juice.Close again the benefit people of whitish honey food." 3. " Japan hanako materia medica ": " quenches the thirst, happy color."
Aleuritopteris argentea (Gmel.) Fee: source: " Shanxi Chinese medicinal herbal ".Another name: Herba Melicae Scabrosae (" Shanxi Chinese medicinal herbal "), spasmolytic grass, gold thread copper sheet, gagger grass (" Zhejiang natural resources of Chinese medicinal materials register "), HERBA ALEURITOPTERIS, child's fist, Herba Lycopodii (" Henan Chinese herbal medicine handbook ").Source: for the Herb of Sinopteridaceae plant Aleuritopteris argentea (Gmel.) Fee.Autumn collects, and dries.Nature and flavor: " Henan Chinese herbal medicine handbook ": " property is put down, lightly seasoned；Leaf: bitter in the mouth." cure mainly: cough-relieving, regulating menstruation, damp eliminating.Control cough, menoxenia, leucorrhea with red and white discharge.1. " Shanxi Chinese medicinal herbal ": " promoting blood circulation to restore menstrual flow." 2. " Zhejiang natural resources of Chinese medicinal materials register ": " is controlled children's and is shied contraction tic." 3. " register planted by Guangxi medicine ": " cough-relieving, controls gynaecological disease, " 4. " Henan Chinese herbal medicine handbook ": " promoting blood flow to regulate menstruation, damp eliminating, cold expelling, pain relieving."
Shepherd's purse: source: " not Lu ".Another name:, (" elegant "), Fructus Pruni ginseng (" Bencao Tujing "), Folium Pruni Radix Adenophorae (Radix Glehniae), flour root (herbal for Relief of Famines), sweet Radix Platycodonis (" detailed outline "), soil Radix Platycodonis (" book on Chinese herbal medicine is original "), RADIX ADENOPHORAE (" Bencao Congxin "), Mei Can, the Radix Adenophorae (Radix Glehniae) that comes into leaves (" Zhejiang conventional medical herbs among the people ").Source: for the root of Campanulaceae shepherd's purse.Nature and flavor: sweet, cold.1. " not Lu ": " sweet, cold." 2. " a thousand pieces of gold wing book on Chinese herbal medicine ": " is nontoxic." 3. " Bencao Congxin ": " is sweet light, is slightly cold." return through: 1. " must join book on Chinese herbal medicine ": " enters meridian of Hand-TAI YIN." 2. " book on Chinese herbal medicine is looked for the truth ": " enters lung, spleen." cure mainly: heat clearing away, removing toxic substances, reduce phlegm.Control cough caused by dryness, laryngalgia, quench one's thirst, furuncle swelling toxin.1. " not Lu ": " solve hundred poison of drug." 2. " dietitian's heart mirror ": " profit lung qi, and in, improving eyesight, pain relieving." 3. " Japan hanako materia medica ": " is controlled snakeworm and is stung, fanatical temperature disease, affixes one's name to poisoned arrow." 4. " detailed outline ": " main cough, persistent erection of the penis of quenching one's thirst, sore furuncle swells." 5. " decoction pieces is newly joined ": " controls deficient lung-heat type cough, born fluid, and steaming is moved back in nourishing the stomach." 6. " medicinal herbs among the people of science ": " is suitable for pharyngolaryngitis, acute tracheitis etc., and stick-slip is eliminated the phlegm." 7. " Zhejiang Chinese medicine handbook ": " lung heat clearing fire, dryness-transformation expectorant.Control cough due to lung-heat, treat ambition stagnation of pathogenic heat."
Radix Linderae Chunii: source: Guangzhou army " conventional Chinese herbal medicine handbook ".Another name: iron wire tree (Guangzhou army " conventional Chinese herbal medicine handbook "), rake teeth hook (" Chinese Higher plant illustrated handbook ").Source: for the root of canella white glue wood.The whole year can adopt.Nature and flavor: Guangzhou army " conventional Chinese herbal medicine handbook ": " pungent, temperature." curing mainly: Guangzhou army " conventional Chinese herbal medicine handbook ": " promoting the circulation of QI to relieve pain, dissipating blood stasis for subsidence of swelling.Control treating swelling and pain by traumatic injury, rheumatic ostalgia, flatulence."
Receptaculum fici Henryi: source: come from 1. " Jiangxi medical herbs ".2. " Zhiwu Mingshi Tukao ": cliffstone pomegranate, in dish calculogenesis.I.e. Fructus Fici Pumilae one class, and real big only such as Arillus Longan.Yunnan custom also thinks powder.Leaf is puckery, the most micro-different.Another name: cliffstone pomegranate, Shi Pengpeng, little Fructus Fici Pumilae, Fructus Fici Pumilae, Ba Lizi, precipice pear, milk Pu, len-til, precipice Fructus Litchi, rock Folium Eriobotryae, joint hinge.Source: medical material Ji Yuan: for the fruit of moraceae plants Radix Thalictri Trichopi.Latin plant animal mineral name: Ficus samentosa Buch.-Ham.exJ.E.Smith var.Henryi(King Ex Oliv.) and Corner [F.henryi King exOliv. " gather and store: autumn picking fruit, dries.Nature and flavor: sweet puckery；Flat；Nontoxic.Gui Jing: lung meridian.Cure mainly: reducing swelling and alleviating pain；Hemostasis.The main testis swelling and hanging down of either of the testes；Traumatic injury；Internal pile hematochezia.
Radix Salviae Miltiorrhizae: another name: Arisaema balansae Engl., Radix Campylotropis Hirtella (Herba Myrsines Africanae), Herba Wedeliae Wallichii root, blood mountain root, RADIX SALVIAE MILTIORRHIZAE, Radix Salviae Miltiorrhizae.Source: this product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bunge..Spring, season in autumn two excavate, and remove silt, are dried.Note: congener still have following several, be also used as medicine as Radix Salviae Miltiorrhizae in different regions: (1) salvia bowleyana Dunn Salvia bowleyana Dunn；(2) Salvia przewalskii Maxim. Salvia przewalskii Maxim.；(3) brown hair Radix Salviae Miltiorrhizae Salvia przewalskii Maxim. var. Mandarinorum (Diels) Stib.；(4) Yunnan Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bge, tor Radix Salviae Miltiorrhizae, dark purple dish) Salvia yunnanensis C. H. Wright, is used as medicine with " Radix Salviae Miltiorrhizae " in Yunnan Province；(5) Salvia kiaometiensis Levl.f.pubescens Stib. (rat-tail) Salvia Kiaometiensis Levl., f. pubescens Stib.；(6) Salvia miltiorrhiza f. Salvia miltiorrhiza Bunge var. alba C. Y. Wu et H. W. Li, mss..Additionally, salvia digitaloides Diels Salvia Also are used as medicine as Radix Salviae Miltiorrhizae in digitaloides Diels, salvia trijuga Diels S. trijuga Diels and little Radix Salviae Miltiorrhizae S. plectranthoides Girff. certain areas.Nature and flavor: bitter, are slightly cold.Gui Jing: GUIXIN, Liver Channel.Curing mainly: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia；Hepatosplenomegaly, angina pectoris.
Radix Notoginseng: source: this product is panax araliaceae plant Panax The dry root of notoginseng (Burk.) F. H. Chen.Autumn excavates before the flowers are in blossom, cleans, separately main root, supporting root and stem foot, is dried.Supporting root is practised and is claimed " rib ", and stem foot is practised and claimed " clip ".Nature and flavor: hardship sweet, micro-, temperature.Gui Jing: return liver, stomach warp.Cure mainly: dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting blood, spit blood, epistaxis, to have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.
Cyperus michelianus(L.) Link (Herba Cyperi Micheliani): another name: rotation grain husk dried tuber, rotation squama dried tuber.Source: Cyperaceae Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) Cyperus Michelianus (L.) Link [Scirpus Michelianus L.], with all herbal medicine.Nature and flavor: light, pungent are flat.Cure mainly: circulation of qi promoting regulating menstruation.Cure mainly dysmenorrhea, pass the appointed time or January 2～3 persons through row.
Folium Isatidis: source: this product is cruciferae isatis Isatis The dried leaves of indigotica Fort..In the summer, divide in season in autumn two 2～3 times and gather, remove impurity, dry.Nature and flavor: bitter, cold.Gui Jing: GUIXIN, stomach warp.Cure mainly: heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Join the army for pathogenic warmth, unconsciousness due to high fever, send out speckle dermexanthesis, jaundice, hematodiarrhoea, mumps, sore throat, erysipelas, carbuncle.
Ramulus Sambuci Williamsii: another name: justice is old, pubescent angelica root, horse urine are disturbed, Radix seu folium Gaultheriae intermediae [Shaanxi].Source: Caprifoliaceae Sambucus plant Ramulus Sambuci Williamsii Sambucus williamsii Hance, is used as medicine with Herb.Xia Qiu gathers, and dries.Nature and flavor: sweet, bitter are flat.Gui Jing: return Liver Channel.Cure mainly: reunion of bone, promoting blood circulation and stopping pain, expelling wind and removing dampness.For fracturing, traumatic injury, rheumatic arthritis, gout, Kaschin-Beck disease, acute and chronic nephritis；Wound hemorrhage is controlled in external.
Herba Hedyotis scabridae: another name: to sitting silk ball on leaf, leaf, four official report pass, Herba Alternantherae sessilis, bone leaves.Source: Rubiaceae plants of Hedyotis meropodium rough Auricled Hedyotis Herb Hedyotis uncinella Hook. et Arn. Var. scabrida [Oldenlandia uncinella (Hook. et Arn.) O. Ktunze var. Scabrida (Franch.) Hand.-Mazz.], with all herbal medicine.The whole year can adopt, and cleans and dries.Nature and flavor: sweet, pungent are cool.Cure mainly: expelling wind and removing dampness, spleen invigorating removing food stagnancy, heat-clearing and toxic substances removing.For rheumatic arthritis, infantile malnutrition, chronic diarrhea, dysentery, ulcerative gingivitis；Skin pruritus, conjunctivitis are controlled in external..
Herb Pararuelliae delavayanae: source: " choosing of Yunnan Chinese herbal medicine ".Another name: ground hide glue, Folium Ainslaea Triflorae, maggot medicine (" Yunnan Chinese herbal medicine ").Source: for the herb of acanthaceous plant happiness oak little bud Herba Rostellulariae.Summer, autumn gather, and chopping is dried.Nature and flavor: " Yunnan Chinese herbal medicine ": " sweet light, flat." cure mainly: heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Control pneumonia, tonsillitis, parotitis, scrofula, abscess sore, fracture, traumatic infection.1. " Yunnan Chinese herbal medicine ": " heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Control fracture, tuberculous lymphadenitis, parotitis, traumatic hemorrhage." 2. " choosing of Yunnan Chinese herbal medicine ": " antiinflammatory is drawn out pus by applying a plaster to the affected part, granulation promoting, dissipating blood stasis tissue regeneration promoting, parasite killing.Control acute suppurative tonsillitis, pneumonia, sore abscess, the raw maggot of wound infection." 3. " catalogue planted by Guizhou medicine ": " controls impairment caused by overstrain, delivers."
Aleuritopteris argentea (Gmel.) Fee: another name: Herba Melicae Scabrosae (" Shanxi Chinese medicinal herbal "), spasmolytic grass, gold thread copper sheet, gagger grass (" Zhejiang natural resources of Chinese medicinal materials register "), HERBA ALEURITOPTERIS, child's fist, Herba Lycopodii (" Henan Chinese herbal medicine handbook ").Source: " Shanxi Chinese medicinal herbal ".Source: for the Herb of Sinopteridaceae plant Aleuritopteris argentea (Gmel.) Fee.Autumn collects, and dries.Nature and flavor: " Henan Chinese herbal medicine handbook ": " property is put down, lightly seasoned；Leaf: bitter in the mouth." cure mainly: cough-relieving, regulating menstruation, damp eliminating.Control cough, menoxenia, leucorrhea with red and white discharge.1. " Shanxi Chinese medicinal herbal ": " promoting blood circulation to restore menstrual flow." 2. " Zhejiang natural resources of Chinese medicinal materials register ": " is controlled children's and is shied contraction tic." 3. " register planted by Guangxi medicine ": " cough-relieving, controls gynaecological disease, " 4. " Henan Chinese herbal medicine handbook ": " promoting blood flow to regulate menstruation, damp eliminating, cold expelling, pain relieving.".
Herba Senecionis Dianthui: source: " Chinese herbal medicine is commonly used in Tibet ".Another name: elm Gu Xing Gaer cloth (Tibetan name).Source: for the herb of feverfew Herba Senecionis Dianthui.7～JIUYUE gather.Nature and flavor: bitter, cold.Cure mainly: expelling wind and removing dampness, heat-clearing and toxic substances removing, antipruritic, control acute conjunctivitis, furuncle, dermatitis, traumatic injury.
Gaultheria: another name: Caulis et folium gaultheriae yunnanensis tree, little Herba speranskiae tuberculatae, Caulis et folium gaultheriae yunnanensis, Radix Morindae Officinalis, Linesless charcoal, Herba speranskiae tuberculatae [Yunnan, Guizhou], MANSHANXIANG, Caulis et Folium piperis, leaf of having a bath, teaberry.Source: for Ericaceae Gaultheria plant Caulis et folium gaultheriae yunnanensis Gaultheria yunnanensis (Franch.) Rehd., be used as medicine with Herb.The whole year can adopt, and clean cutting is dried or using fresh herb.Nature and flavor: pungent, temperature.Cure mainly: expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, promoting blood circulation and stopping pain.For rheumatic arthritis, traumatic injury, cold syndrome of the stomach pain.Anemofrigid cold.
White residual flower: another name: Flos rosae multiflorae.Source: Flos Rosae Multiflorae actions and spoken parts in classical Chinese drama residual flower Rosa Multiflora Thunb. var. cathayensis Rehd. et Wils., is used as medicine with flower, root.Nature and flavor: bitter, puckery, cold.Cure mainly: flower: clearing away summer-heat heat, removing dampness is turbid, pleasant stomach function regulating.Cure mainly summer-heat uncomfortable in chest, thirsty, vomiting, anorexia, aphtha erosion of the oral mucosa.Consumption 1～3 money.Root: promoting blood circulation to remove obstruction in the collateral.Cure mainly arthritis, facial paralysis.Consumption 0.5～1 liang, be decocted in water for oral dose；External is ground into powder and can be controlled scald.
Rhizoma Cimicifugae: another name: big cattle card holder, Radix Longan, hole root of the tooth.Source: this product is ranunculaceae plant C.heracleifolia Cimicifuga heracleifolia Kom., Cimicifuga Dahurica Cimicifuga Dahurica (Turcz.) Maxim. or the dry rhizome of Rhizoma Cimicifugae Cimicifuga foetida L..Autumn excavates, and removes silt, when solarization to fibrous root is done, burns or remove fibrous root, drying.Nature and flavor: pungent, micro-sweet, are slightly cold.Gui Jing: return lung, spleen, stomach, large intestine channel.Cure mainly: deliver rash, heat-clearing and toxic substances removing, rise and lift yang-energy.For headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome sends out speckle；Proctoptosis, uterine prolapse.
Fructus Jujubae: source: this product is Rhamnaceae jujube Fructus Jujubae Ziziphus The dry mature fruit of jujuba Mill. var. inermis (Bunge) Rehd..Gather during fruit maturation in autumn, dry.Its root, bark are also used as medicine, and can adopt at any time.Nature and flavor: sweet, temperature.Gui Jing: return spleen, stomach warp.Cure mainly: really (Fructus Jujubae): invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.Bark: antiinflammatory, hemostasis, antidiarrheal.For tracheitis, enteritis, dysentery, metrorrhagia；Traumatic hemorrhage is controlled in external.Root: circulation of qi promoting, invigorates blood circulation, regulating menstruation.For menoxenia, red collapse, leucorrhea.
Fructus Lycii: source: this product is plant of Solanaceae lycium barbarum Lycium The dry mature fruit of barbarum L..Summer, season in autumn two fruit are gathered when taking on a red color, hot-air seasoning, remove carpopodium.Or dry in the air to rhicnosis, dry, remove carpopodium.Nature and flavor: sweet are flat.Gui Jing: return liver, kidney channel.Cure mainly: nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat quenches one's thirst, and blood deficiency and yellow complexion, blurred vision is failed to understand.
Cortex cynoglossi zeylanici radicis: source: " Shaanxi Chinese herbal medicine ".Another name: Radix Clematidis Clarkeanae, iron plate road, Sonchus arvensis L. grass.Source: for root bark and the leaf of the big Fructus Lithospermi Zollingeri of comfrey.Spring, summer gather.Nature and flavor: bitter, cold.Cure mainly: heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, propose pus and growing muscle, regulating menstruation.Control furuncle carbuncle, venom, traumatic injury, fracture, menoxenia.
Radix Glycyrrhizae: source: this product is glycyrrhizic legume Glycyrrhiza Uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or the dry root of Glycyrrhiza glabra L. Glycyrrhiza glabra L..Spring, season in autumn two excavate, and remove fibrous root, dry.Nature and flavor: sweet are flat.Gui Jing: GUIXIN, lung, spleen, stomach warp .Cure mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.
Lignum Dalbergiae Odoriferae: another name: mountain Fructus Citri tangerinae, Acronychi apedunculata (L.) Miq..Source: Rutaceae Acronychi apedunculata (L.) Miq. platymiscium Lignum Dalbergiae Odoriferae Acronychia Pedunculata (L.) Miq., is used as medicine with root, heartwood, leaf, fruit.The fruit autumn and winter adopt, and remainder is adopted the whole year, and section is dried or dries in the shade.Nature and flavor: sweet are flat.Cure mainly: root, dry wood, leaf: expelling wind and activating blood circulation, regulating QI to relieve pain.For rheumatic lumbago and scelalgia, treating swelling and pain by traumatic injury, bronchitis, stomachache, colicky.Fruit: invigorating the stomach and promoting digestion.For inappetence, dyspepsia.
RHIZOMA POLYGONI SUFFULTI: another name: Radix Euphorbiae [Hubei, Sichuan], screw Radix Notoginseng, Streptopus simplex D. Don, Rhizoma Polygoni sinensis, Herba Polygoni Runcinati [Guizhou], knotweed seven, Rhizoma Polygoni suffulti, Herba hyperici attenuati [Shaanxi].Source: for Polygonaceae arsesmart RHIZOMA POLYGONI SUFFULTI Polygonum suffultum Maxim., be used as medicine with root stock.Autumn excavates, and cleans, and section is dried standby.Nature and flavor: bitter, puckery are cool.Cure mainly: astringing to arrest bleeding, pain relieving granulation promoting.For traumatic injury, traumatic hemorrhage, have blood in stool, metrorrhagia, dysentery, proctoptosis.
nullDescribed pharmaceutical composition is made up of the raw medicinal material of following parts by weight: white residual flower 10-20 weight portion、Juice of Lobed Kudzuvine 12-22 weight portion、Fructus Jujubae 15-45 weight portion、Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 13-33 weight portion、Herb Pararuelliae delavayanae 14-28 weight portion、Lignum Dalbergiae Odoriferae 12-22 weight portion、Climbing Viloet Herb 15-35 weight portion、Radix Notoginseng 14-28 weight portion、Folium Isatidis 15-25 weight portion、Radix Glycyrrhizae 10-40 weight portion、Ramulus Sambuci Williamsii 14-32 weight portion、Radix Salviae Miltiorrhizae 15-25 weight portion、Herba Hedyotis scabridae 11-21 weight portion、Gaultheria 13-33 weight portion、Receptaculum fici Henryi 10-30 weight portion、Cortex cynoglossi zeylanici radicis 15-25 weight portion、Radix Linderae Chunii 12-32 weight portion、RHIZOMA POLYGONI SUFFULTI 14-28 weight portion、Shepherd's purse 13-33 weight portion、Xi 11-21 weight portion、Rhizoma Cimicifugae 10-30 weight portion、Herba Senecionis Dianthui 15-35 weight portion、Fructus Lycii 10-20 weight portion and Aleuritopteris argentea (Gmel.) Fee 15-32 weight portion.
nullDescribed pharmaceutical composition is made up of the raw medicinal material of following parts by weight: white residual flower 12-20 weight portion、Juice of Lobed Kudzuvine 14-20 weight portion、Fructus Jujubae 15-45 weight portion、Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 15-30 weight portion、Herb Pararuelliae delavayanae 15-28 weight portion、Lignum Dalbergiae Odoriferae 12-22 weight portion、Climbing Viloet Herb 15-35 weight portion、Radix Notoginseng 14-28 weight portion、Folium Isatidis 15-25 weight portion、Radix Glycyrrhizae 10-40 weight portion、Ramulus Sambuci Williamsii 15-30 weight portion、Radix Salviae Miltiorrhizae 15-25 weight portion、Herba Hedyotis scabridae 12-20 weight portion、Gaultheria 13-33 weight portion、Receptaculum fici Henryi 10-30 weight portion、Cortex cynoglossi zeylanici radicis 15-25 weight portion、Radix Linderae Chunii 14-30 weight portion、RHIZOMA POLYGONI SUFFULTI 14-28 weight portion、Shepherd's purse 15-32 weight portion、Xi 12-20 weight portion、Rhizoma Cimicifugae 10-30 weight portion、Herba Senecionis Dianthui 15-35 weight portion、Fructus Lycii 10-20 weight portion and Aleuritopteris argentea (Gmel.) Fee 15-30 weight portion.
Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: white residual flower 14 weight portion, juice of Lobed Kudzuvine 15 weight portion, Fructus Jujubae 35 weight portion, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 25 weight portion, Herb Pararuelliae delavayanae 22 weight portion, Lignum Dalbergiae Odoriferae 15 weight portion, Climbing Viloet Herb 32 weight portion, Radix Notoginseng 20 weight portion, Folium Isatidis 17 weight portion, Radix Glycyrrhizae 40 weight portion, Ramulus Sambuci Williamsii 25 weight portion, Radix Salviae Miltiorrhizae 22 weight portion, Herba Hedyotis scabridae 14 weight portion, Gaultheria 33 weight portion, Receptaculum fici Henryi 20 weight portion, Cortex cynoglossi zeylanici radicis 21 weight portion, Radix Linderae Chunii 30 weight portion, RHIZOMA POLYGONI SUFFULTI 22 weight portion, shepherd's purse 32 weight portion, Xi 12 weight portion, Rhizoma Cimicifugae 20 weight portion, Herba Senecionis Dianthui 32 weight portion, Fructus Lycii 15 weight portion and Aleuritopteris argentea (Gmel.) Fee 20 weight portion.
Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: white residual flower 18 weight portion, juice of Lobed Kudzuvine 20 weight portion, Fructus Jujubae 40 weight portion, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 30 weight portion, Herb Pararuelliae delavayanae 24 weight portion, Lignum Dalbergiae Odoriferae 21 weight portion, Climbing Viloet Herb 32 weight portion, Radix Notoginseng 24 weight portion, Folium Isatidis 15 weight portion, Radix Glycyrrhizae 30 weight portion, Ramulus Sambuci Williamsii 25 weight portion, Radix Salviae Miltiorrhizae 19 weight portion, Herba Hedyotis scabridae 16 weight portion, Gaultheria 32 weight portion, Receptaculum fici Henryi 20 weight portion, Cortex cynoglossi zeylanici radicis 22 weight portion, Radix Linderae Chunii 30 weight portion, RHIZOMA POLYGONI SUFFULTI 26 weight portion, shepherd's purse 31 weight portion, Xi 13 weight portion, Rhizoma Cimicifugae 25 weight portion, Herba Senecionis Dianthui 33 weight portion, Fructus Lycii 15 weight portion and Aleuritopteris argentea (Gmel.) Fee 30 weight portion.
Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: white residual flower 16 weight portion, juice of Lobed Kudzuvine 17 weight portion, Fructus Jujubae 45 weight portion, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 20 weight portion, Herb Pararuelliae delavayanae 15 weight portion, Lignum Dalbergiae Odoriferae 17 weight portion, Climbing Viloet Herb 33 weight portion, Radix Notoginseng 22 weight portion, Folium Isatidis 18 weight portion, Radix Glycyrrhizae 30 weight portion, Ramulus Sambuci Williamsii 25 weight portion, Radix Salviae Miltiorrhizae 19 weight portion, Herba Hedyotis scabridae 12 weight portion, Gaultheria 31 weight portion, Receptaculum fici Henryi 20 weight portion, Cortex cynoglossi zeylanici radicis 17 weight portion, Radix Linderae Chunii 30 weight portion, RHIZOMA POLYGONI SUFFULTI 21 weight portion, shepherd's purse 30 weight portion, Xi 18 weight portion, Rhizoma Cimicifugae 23 weight portion, Herba Senecionis Dianthui 32 weight portion, Fructus Lycii 15 weight portion and Aleuritopteris argentea (Gmel.) Fee 28 weight portion.
When the dosage form of described pharmaceutical composition is paster agent, its preparation method comprises the following steps:
The first step: Herba Hedyotis scabridae, Gaultheria, Receptaculum fici Henryi, Cortex cynoglossi zeylanici radicis, Radix Linderae Chunii, RHIZOMA POLYGONI SUFFULTI, shepherd's purse and Xi are mixed in described ratio, soak with ethanol with the determining alcohol 85%～95% of 3～5 times of the mixture quality relative to acquisition, extract after being heated to reflux 2～4 hours, filter, obtain the first filtrate；By filtering residue again by the soak with ethanol of the determining alcohol 85%～95% relative to 1～2 times of mixture quality obtained, extract after being heated to reflux 1～2 hour, filter, obtain the second filtrate；Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first with deionized water or the distilled water eluting of 5 times of resin column volumes, it is 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol elution, concentrating under reduced pressure removes ethanol, is dried and is ground into powder；
Second step, Rhizoma Cimicifugae, Herba Senecionis Dianthui, Fructus Lycii and Aleuritopteris argentea (Gmel.) Fee are mixed in described ratio, the alcohol heating reflux adding the determining alcohol 85%～95% relative to 2～4 times of mixture quality obtained extracts 1～2 time, extracting solution merges, it is centrifuged remove impurity with tube centrifuge, when extracting solution after remove impurity is evaporated under conditions of 60 DEG C～70 DEG C 60 DEG C, relative density is the mastic of 1.20～1.23, and the mastic spray dryer after concentrating is dried to powder；
3rd step, is mixed surplus stock medical material in described ratio, adds the water soaking relative to 2～4 times of mixture quality obtained, and heating decocts 2～4 hours, filters；By filtering residue again with the water soaking of 1～2 times of the mixture quality relative to acquisition, heating decoction 1～2 hour, filter；Merging the filtrate of twice, concentrating under reduced pressure removes moisture, is dried and is ground into powder；
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the rubber relative to 1～2 times of described mixture of powders quality sum, the Colophonium of 1～2 times, mixing, make coating, carry out being coated with cream, cut off, lid lining, section, i.e. obtain described paster agent.
When the dosage form of described pharmaceutical composition is granule, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 85%～95% relative to mixture 4～8 times, it is heated to boiling reflux 3～5 hours, filter, use percolation with per minute 1～2ml speed slowly percolation, collect percolate, when being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa, relative density is the mastic of 1.04～1.10, it is spray-dried, the inlet temperature 160 of spray dryer～175 DEG C, leaving air temp 80～85 DEG C, be ground into powder subsequently, make dried cream powder；
Second step, adds relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times and the dextrin of 0.1～0.2 times in the dried cream powder obtained, makes granule, is dried in 40～50 DEG C, it is thus achieved that granule.
When the dosage form of described pharmaceutical composition is liniment, its preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, further pulverizes, crosses 100 mesh sieves, enables and is at least up to 40% by the fine powder amount of 100 mesh sieves, collects and obtains fine powder a by the fine powder of 100 mesh sieves；
Step 2: the coarse powder that will not pass through 100 mesh sieves puts into multi-function extractor extraction twice, adds weight portion 8-10 times amount soak by water 1-3 hour for the first time, and second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate；The heating of gained filtrate is concentrated into pasty state, and after putting into the drying of 80 DEG C of baking oven, room temperature cools down, and grinds to form fine powder b；
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
Hereinafter using embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 paster agent
The manufacturing process of paster agent of the present invention is: take white residual flower 140g, juice of Lobed Kudzuvine 150g, Fructus Jujubae 350g, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 250g, Herb Pararuelliae delavayanae 220g, Lignum Dalbergiae Odoriferae 150g, Climbing Viloet Herb 320g, Radix Notoginseng 200g, Folium Isatidis 170g, Radix Glycyrrhizae 400g, Ramulus Sambuci Williamsii 250g, Radix Salviae Miltiorrhizae 220g, Herba Hedyotis scabridae 140g, Gaultheria 330g, Receptaculum fici Henryi 200g, Cortex cynoglossi zeylanici radicis 210g, Radix Linderae Chunii 300g, RHIZOMA POLYGONI SUFFULTI 220g, shepherd's purse 320g, Xi 120g, Rhizoma Cimicifugae 200g, Herba Senecionis Dianthui 320g, Fructus Lycii 150g and Aleuritopteris argentea (Gmel.) Fee 200g；
The first step: Herba Hedyotis scabridae, Gaultheria, Receptaculum fici Henryi, Cortex cynoglossi zeylanici radicis, Radix Linderae Chunii, RHIZOMA POLYGONI SUFFULTI, shepherd's purse and Xi are mixed in described ratio, soak with ethanol with the determining alcohol 90% of 4 times of the mixture quality relative to acquisition, extract after being heated to reflux 3 hours, filter, obtain the first filtrate；By filtering residue again by the soak with ethanol of the determining alcohol 95% relative to 1.5 times of mixture quality obtained, extract after being heated to reflux 2 hours, filter, obtain the second filtrate；Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first with deionized water or the distilled water eluting of 5 times of resin column volumes, it is 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol elution, concentrating under reduced pressure removes ethanol, is dried and is ground into powder；
Second step, Rhizoma Cimicifugae, Herba Senecionis Dianthui, Fructus Lycii and Aleuritopteris argentea (Gmel.) Fee are mixed in described ratio, the alcohol heating reflux adding the determining alcohol 95% relative to 3 times of mixture quality obtained extracts 1.5 times, extracting solution merges, it is centrifuged remove impurity with tube centrifuge, it is the mastic of 1.22 that extracting solution after remove impurity is evaporated under conditions of 70 DEG C relative density when 60 DEG C, and the mastic spray dryer after concentrating is dried to powder；
3rd step, is mixed surplus stock medical material in described ratio, adds the water soaking relative to 3 times of mixture quality obtained, and heating decocts 4 hours, filters；By filtering residue again with the water soaking of 2 times of the mixture quality relative to acquisition, heating decoction 1.5 hours, filter；Merging the filtrate of twice, concentrating under reduced pressure removes moisture, is dried and is ground into powder；
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the rubber relative to 2 times of described mixture of powders quality sum, the Colophonium of 1.5 times, mixing, make coating, carry out being coated with cream, cut off, lid lining, section, i.e. obtain described paster agent
Embodiment 2 granule
The manufacturing process of granule of the present invention is: take white residual flower 180g, juice of Lobed Kudzuvine 200g, Fructus Jujubae 400g, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 300g, Herb Pararuelliae delavayanae 240g, Lignum Dalbergiae Odoriferae 210g, Climbing Viloet Herb 320g, Radix Notoginseng 240g, Folium Isatidis 150g, Radix Glycyrrhizae 300g, Ramulus Sambuci Williamsii 250g, Radix Salviae Miltiorrhizae 190g, Herba Hedyotis scabridae 160g, Gaultheria 320g, Receptaculum fici Henryi 200g, Cortex cynoglossi zeylanici radicis 220g, Radix Linderae Chunii 300g, RHIZOMA POLYGONI SUFFULTI 260g, shepherd's purse 310g, Xi 130g, Rhizoma Cimicifugae 250g, Herba Senecionis Dianthui 330g, Fructus Lycii 150g and Aleuritopteris argentea (Gmel.) Fee 300g；
The first step, described raw medicinal material is mixed in described ratio, adds the ethanol that determining alcohol is 95% relative to 6 times of mixture, be heated to boiling reflux 4 hours, filter, using percolation with the speed slowly percolation of 2ml per minute, collect percolate, being evaporated to relative density when 55 DEG C subsequently under vacuum 0.07Mpa is the mastic of 1.05, it is spray-dried, the inlet temperature of spray dryer 170 DEG C, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder；
Second step, adds the cane sugar powder relative to dried cream powder quality 0.3 times and the dextrin of 0.15 times in the dried cream powder obtained, makes granule, is dried in 45 DEG C, it is thus achieved that granule.
Embodiment 3 liniment
The manufacturing process of liniment of the present invention is: take white residual flower 160g, juice of Lobed Kudzuvine 170g, Fructus Jujubae 450g, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 200g, Herb Pararuelliae delavayanae 150g, Lignum Dalbergiae Odoriferae 170g, Climbing Viloet Herb 330g, Radix Notoginseng 220g, Folium Isatidis 180g, Radix Glycyrrhizae 300g, Ramulus Sambuci Williamsii 250g, Radix Salviae Miltiorrhizae 190g, Herba Hedyotis scabridae 120g, Gaultheria 310g, Receptaculum fici Henryi 200g, Cortex cynoglossi zeylanici radicis 170g, Radix Linderae Chunii 300g, RHIZOMA POLYGONI SUFFULTI 210g, shepherd's purse 300g, Xi 180g, Rhizoma Cimicifugae 230g, Herba Senecionis Dianthui 320g, Fructus Lycii 150g and Aleuritopteris argentea (Gmel.) Fee 280g；
Step one: first described raw medicinal material is ground into coarse powder, further pulverizes, crosses 100 mesh sieves, enables and is at least up to 40% by the fine powder amount of 100 mesh sieves, collects and obtains fine powder a by the fine powder of 100 mesh sieves；
Step 2: the coarse powder that will not pass through 100 mesh sieves puts into multi-function extractor extraction twice, adds weight portion 9 times amount soak by water 2 hours for the first time, and second time adds weight portion 8 times amount soak by water 2 hours, merges twice decocting liquid, filters to get filtrate；The heating of gained filtrate is concentrated into pasty state, and after putting into the drying of 80 DEG C of baking oven, room temperature cools down, and grinds to form fine powder b；
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
Acute skin irritation test:
These product are according to 6.3 joint in Ministry of Public Health " cosmetics health specification " (2002) Part II " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg～3kg, the paster agent prepared by embodiments of the invention 1 is placed directly against on the left of animal on skin (opposite side is as comparison), use blocking test, 4 hours application time, tested material is remained with warm water washing after off-test, 1h after removing tested material, 24h, 48h and 72h observes the tested district of animal and the dermoreaction of check plot respectively, top average is " 0 ", judge that these product are to animal skin nonirritant.
Acute toxicity test:
Application NIH mice 40, SPF level, male and female half and half, body weight 18～22g, carry out acute toxicity test.Mice is randomly divided into two groups, often group 20, i.e. matched group and administration group, fasting 12 hours before experiment；Granule prepared by embodiments of the invention 2 is dissolved in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume be 5ml/kg(i.e. unit dosage form be 32.9 crude drugs/kg), matched group gives normal saline, within one day, is administered 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Test result indicate that: compare with matched group, after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase the most normal.Granule LD50 > 32.9 crude drugs/the kg of the Mouse oral gavage present invention, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.The Chinese medicine clinical application amount of the present invention is 4.4g crude drug/day/people, and adult's body weight is in terms of 60KG, and average dosage is 0.073g crude drug/kg/ day.By weighing machine: as quantity 901 times of the dosis tolerata of the pharmaceutical composition of mice (average weight is in terms of 20g) the oral administration gavage present invention.Therefore the granule acute toxicity of the embodiment of the present invention 2 is low, clinical drug safety.
Long term toxicity test:
Mice is pressed 10.78,20.35 and 33.48g crude drugs/kg continuous use 16 weeks (1.0ml/100g body weight by the liniment of the embodiment of the present invention 3, every day 2 times) and drug withdrawal 4 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by Chinese medicine of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 16 weeks and drug withdrawal 4 weeks, Organs of Mice is all without substantially changing.Illustrate that the liniment of the embodiment of the present invention 3 is little to toxicity after mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
Clinical data:
Male 414 examples of this group of physical data, female 261 example.Left side 372 examples, right side 293 example, bilateral 10 example.Age 19-82 year.Injured reason: traffic accident 252 example, traumatic injury 174 example, injure 148 examples by a crashing object, other reason 101 example.Classification of fracture: comminuted 227 examples, oblique 267 examples, spiral type 86 example, horizontal shape 95 example.675 example patients are randomly divided into:
Patch tablet in treatment group: 175 people, male 114 people, female 61 people；Left side 104 examples, right side 68 example, bilateral 3 example.
Granules in Treating group: 171 people, male 101 people, female 70 people；Left side 92 examples, right side 76 example, bilateral 3 example.
Liniment treatment group: 171 people, male 110 people, female 61 people；Left side 93 examples, right side 76 example, bilateral 2 example.
Matched group: 158 people, male 89 people, female 69 people；Left side 83 examples, right side 73 example, bilateral 2 example.
Diagnostic criteria:
1, patient has clear and definite trauma history.
2, thigh local pain is more violent, it is seen that the angulation of thigh, shortening deformity, fracture site often has abnormal movement.
3, position, positive side X-ray film display fracture site, type and direction of displacement.
4, suspect there is blood vessel injury, should row B-mode ultrasonography or angiography.
5, injury of sciatic nerve person's row Neuro electromyograph.
Therapeutic Method:
Treatment by Chinese herbs group:
Patch tablet in treatment group: using the paster agent of the embodiment of the present invention 1 preparation, 2 times on the one, every 7 days is a course for the treatment of;
Granules in Treating group: using the granule of the embodiment of the present invention 2 preparation, three times a day, once a bag, every bag of 6g, every 7 days is a course for the treatment of;
Liniment treatment group: using the liniment of the embodiment of the present invention 3 preparation, 2 times on the one, the most once, every 7 days is a course for the treatment of;
Matched group: oral GUZHE CUOSHANG JIAONANG, 3 times on the one, a 4-6 grain, every 7 days is a course for the treatment of.
Efficacy assessment standard:
Excellent: within suffering limb cripetura 0.5cm, hip, knee joint stretch in the wrong each differ from 15 ° within, x-ray checks anatomical reduction or nearly anatomical reduction.Angulation is person's (within i.e. this physiologic radian differs from 5 °) within 15 °.
Good: suffering limb shortens 0.6-1cm, hip, knee joint are stretched and in the wrong each are differed from 1 °-30 °, do not hinder life and work, and within x-ray inspection fracture overlapping 1cm, angulation is 16 ° of-20 ° of persons.
Shang Ke: suffering limb shortens within 1.1-2cm, and hip, knee joint are stretched and in the wrong each differed from 31 °-45 °, and x-ray inspection fracture overlapping 1.1-2cm, angulation is 21 ° of-25 ° of persons.
Difference: fail to reach above-mentioned requirements person.
Therapeutic outcome:
See table 1, as it can be seen from table 1 use the medicine composite for curing fracture of shaft of femur of the present invention at patient's surgical site infections, relative to conventional medicament on therapeutic effect, have and be markedly improved.
Clinical efficacy comparison after 10 courses for the treatment of treated respectively by 1 four groups of table Example (%)
Group Number of cases Excellent Good Shang Ke Difference Total effective rate
Patch tablet in treatment group 175 153 16 6 0 100%
Granules in Treating group 171 146 16 9 0 100%
Liniment treatment group 171 152 13 6 0 100%
Matched group 158 104 25 21 8 94.9%
Excellent and good number and time comparative example (%) after 10 courses for the treatment of treated respectively by 2 four groups of table
Group Number of cases 1-3 course for the treatment of 4-6 course for the treatment of 7-10 course for the treatment of
Patch tablet in treatment group 169 0(0%) 35(20.7%) 134(79.3%)
Granules in Treating group 162 0(0%) 32(19.8%) 130(80.2%)
Liniment treatment group 165 0(0%) 37(22.4%) 128(77.6%)
Matched group 129 0(0%) 8(6.2%) 121(71.6%)
According to the clinical statistics in above table, the Chinese medicine that the present invention provides has effective percentage height, determined curative effect, safety height, the advantage that has no side effect；Simultaneously to patch excellent and good 169 examples of tablet in treatment group, 165 examples that excellent and good 162 examples of Granules in Treating group, liniment treatment group are excellent and good and the excellent and good 129 example follow-up of patients 1 year half of matched group, result statistics:
169 examples that patch tablet in treatment group is excellent and good, 153 excellent examples, without recurrence, recur 3 examples in 16 good example patients, and relapse rate is 1.8%；
162 examples that Granules in Treating group is excellent and good, 146 excellent examples, without recurrence, recur 3 examples in 16 good example patients, and relapse rate is 1.9%；
165 examples that liniment agent treatment group is excellent and good, 152 excellent examples, without recurrence, recur 2 examples in 13 good example patients, and relapse rate is 1.2%；
The 129 example patients that matched group is excellent and good, 104 excellent examples, without recurrence, recur 5 examples in 25 good example patients, and relapse rate is 3.9%.
Model case: Zhang, man, within 55 years old, to fall, show through X sheet inspection: hypomere fracture in fl, the broken ends of fractured bone misplaces, does not gives special handling, and patient goes home recuperation, but left thigh pain is without alleviating, and slightly touches that the pain increased, and left lower extremity can not walking with load.Outpatient service doctor intends " hypomere fracture in fl " income after health check-up and diagosis and is in hospital and treats further.Since injured, spirit fair, receive can, difference of sleeping night, two just self-regulateds.Give row manual reduction and left tibia tuberosity traction therapy of bone after being admitted to hospital, and coordinate left thigh clamping plate External fixation, take the granule of Chinese medicine preparation embodiment 2 of the present invention simultaneously, one day one bag, treat and substantially cure 3 courses for the treatment of, follow up a case by regular visits to not recur for 1 year half.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.

Claims (9)

1. the pharmaceutical composition treating fracture of shaft of femur, it is characterized in that, described pharmaceutical composition is made up of following raw medicinal material: white residual flower, juice of Lobed Kudzuvine, Fructus Jujubae, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), Herb Pararuelliae delavayanae, Lignum Dalbergiae Odoriferae, Climbing Viloet Herb, Radix Notoginseng, Folium Isatidis, Radix Glycyrrhizae, Ramulus Sambuci Williamsii, Radix Salviae Miltiorrhizae, Herba Hedyotis scabridae, Gaultheria, Receptaculum fici Henryi, Cortex cynoglossi zeylanici radicis, Radix Linderae Chunii, RHIZOMA POLYGONI SUFFULTI, shepherd's purse, Xi, Rhizoma Cimicifugae, Herba Senecionis Dianthui, Fructus Lycii and Aleuritopteris argentea (Gmel.) Fee.
nullThe pharmaceutical composition for the treatment of fracture of shaft of femur the most according to claim 1，It is characterized in that，Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: white residual flower 10-20 weight portion、Juice of Lobed Kudzuvine 12-22 weight portion、Fructus Jujubae 15-45 weight portion、Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 13-33 weight portion、Herb Pararuelliae delavayanae 14-28 weight portion、Lignum Dalbergiae Odoriferae 12-22 weight portion、Climbing Viloet Herb 15-35 weight portion、Radix Notoginseng 14-28 weight portion、Folium Isatidis 15-25 weight portion、Radix Glycyrrhizae 10-40 weight portion、Ramulus Sambuci Williamsii 14-32 weight portion、Radix Salviae Miltiorrhizae 15-25 weight portion、Herba Hedyotis scabridae 11-21 weight portion、Gaultheria 13-33 weight portion、Receptaculum fici Henryi 10-30 weight portion、Cortex cynoglossi zeylanici radicis 15-25 weight portion、Radix Linderae Chunii 12-32 weight portion、RHIZOMA POLYGONI SUFFULTI 14-28 weight portion、Shepherd's purse 13-33 weight portion、Xi 11-21 weight portion、Rhizoma Cimicifugae 10-30 weight portion、Herba Senecionis Dianthui 15-35 weight portion、Fructus Lycii 10-20 weight portion and Aleuritopteris argentea (Gmel.) Fee 15-32 weight portion.
nullThe pharmaceutical composition for the treatment of fracture of shaft of femur the most according to claim 1 and 2，It is characterized in that，Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: white residual flower 12-20 weight portion、Juice of Lobed Kudzuvine 14-20 weight portion、Fructus Jujubae 15-45 weight portion、Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 15-30 weight portion、Herb Pararuelliae delavayanae 15-28 weight portion、Lignum Dalbergiae Odoriferae 12-22 weight portion、Climbing Viloet Herb 15-35 weight portion、Radix Notoginseng 14-28 weight portion、Folium Isatidis 15-25 weight portion、Radix Glycyrrhizae 10-40 weight portion、Ramulus Sambuci Williamsii 15-30 weight portion、Radix Salviae Miltiorrhizae 15-25 weight portion、Herba Hedyotis scabridae 12-20 weight portion、Gaultheria 13-33 weight portion、Receptaculum fici Henryi 10-30 weight portion、Cortex cynoglossi zeylanici radicis 15-25 weight portion、Radix Linderae Chunii 14-30 weight portion、RHIZOMA POLYGONI SUFFULTI 14-28 weight portion、Shepherd's purse 15-32 weight portion、Xi 12-20 weight portion、Rhizoma Cimicifugae 10-30 weight portion、Herba Senecionis Dianthui 15-35 weight portion、Fructus Lycii 10-20 weight portion and Aleuritopteris argentea (Gmel.) Fee 15-30 weight portion.
null4. according to the pharmaceutical composition of the arbitrary described treatment fracture of shaft of femur of claims 1 to 3，It is characterized in that，Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: white residual flower 14 weight portion、Juice of Lobed Kudzuvine 15 weight portion、Fructus Jujubae 35 weight portion、Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 25 weight portion、Herb Pararuelliae delavayanae 22 weight portion、Lignum Dalbergiae Odoriferae 15 weight portion、Climbing Viloet Herb 32 weight portion、Radix Notoginseng 20 weight portion、Folium Isatidis 17 weight portion、Radix Glycyrrhizae 40 weight portion、Ramulus Sambuci Williamsii 25 weight portion、Radix Salviae Miltiorrhizae 22 weight portion、Herba Hedyotis scabridae 14 weight portion、Gaultheria 33 weight portion、Receptaculum fici Henryi 20 weight portion、Cortex cynoglossi zeylanici radicis 21 weight portion、Radix Linderae Chunii 30 weight portion、RHIZOMA POLYGONI SUFFULTI 22 weight portion、Shepherd's purse 32 weight portion、Xi 12 weight portion、Rhizoma Cimicifugae 20 weight portion、Herba Senecionis Dianthui 32 weight portion、Fructus Lycii 15 weight portion and Aleuritopteris argentea (Gmel.) Fee 20 weight portion.
null5. according to the pharmaceutical composition of the arbitrary described treatment fracture of shaft of femur of claims 1 to 3，It is characterized in that，Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: white residual flower 18 weight portion、Juice of Lobed Kudzuvine 20 weight portion、Fructus Jujubae 40 weight portion、Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 30 weight portion、Herb Pararuelliae delavayanae 24 weight portion、Lignum Dalbergiae Odoriferae 21 weight portion、Climbing Viloet Herb 32 weight portion、Radix Notoginseng 24 weight portion、Folium Isatidis 15 weight portion、Radix Glycyrrhizae 30 weight portion、Ramulus Sambuci Williamsii 25 weight portion、Radix Salviae Miltiorrhizae 19 weight portion、Herba Hedyotis scabridae 16 weight portion、Gaultheria 32 weight portion、Receptaculum fici Henryi 20 weight portion、Cortex cynoglossi zeylanici radicis 22 weight portion、Radix Linderae Chunii 30 weight portion、RHIZOMA POLYGONI SUFFULTI 26 weight portion、Shepherd's purse 31 weight portion、Xi 13 weight portion、Rhizoma Cimicifugae 25 weight portion、Herba Senecionis Dianthui 33 weight portion、Fructus Lycii 15 weight portion and Aleuritopteris argentea (Gmel.) Fee 30 weight portion.
null6. according to the pharmaceutical composition of the arbitrary described treatment fracture of shaft of femur of claims 1 to 3，It is characterized in that，Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: white residual flower 16 weight portion、Juice of Lobed Kudzuvine 17 weight portion、Fructus Jujubae 45 weight portion、Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 20 weight portion、Herb Pararuelliae delavayanae 15 weight portion、Lignum Dalbergiae Odoriferae 17 weight portion、Climbing Viloet Herb 33 weight portion、Radix Notoginseng 22 weight portion、Folium Isatidis 18 weight portion、Radix Glycyrrhizae 30 weight portion、Ramulus Sambuci Williamsii 25 weight portion、Radix Salviae Miltiorrhizae 19 weight portion、Herba Hedyotis scabridae 12 weight portion、Gaultheria 31 weight portion、Receptaculum fici Henryi 20 weight portion、Cortex cynoglossi zeylanici radicis 17 weight portion、Radix Linderae Chunii 30 weight portion、RHIZOMA POLYGONI SUFFULTI 21 weight portion、Shepherd's purse 30 weight portion、Xi 18 weight portion、Rhizoma Cimicifugae 23 weight portion、Herba Senecionis Dianthui 32 weight portion、Fructus Lycii 15 weight portion and Aleuritopteris argentea (Gmel.) Fee 28 weight portion.
7. according to the pharmaceutical composition of the arbitrary described treatment fracture of shaft of femur of claim 1 to 6, it is characterised in that when the dosage form of described pharmaceutical composition is paster agent, its preparation method comprises the following steps:
The first step: Herba Hedyotis scabridae, Gaultheria, Receptaculum fici Henryi, Cortex cynoglossi zeylanici radicis, Radix Linderae Chunii, RHIZOMA POLYGONI SUFFULTI, shepherd's purse and Xi are mixed in described ratio, soak with ethanol with the determining alcohol 85%～95% of 3～5 times of the mixture quality relative to acquisition, extract after being heated to reflux 2～4 hours, filter, obtain the first filtrate；By filtering residue again by the soak with ethanol of the determining alcohol 85%～95% relative to 1～2 times of mixture quality obtained, extract after being heated to reflux 1～2 hour, filter, obtain the second filtrate；Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first with deionized water or the distilled water eluting of 5 times of resin column volumes, it is 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol elution, concentrating under reduced pressure removes ethanol, is dried and is ground into powder；
Second step, Rhizoma Cimicifugae, Herba Senecionis Dianthui, Fructus Lycii and Aleuritopteris argentea (Gmel.) Fee are mixed in described ratio, the alcohol heating reflux adding the determining alcohol 85%～95% relative to 2～4 times of mixture quality obtained extracts 1～2 time, extracting solution merges, it is centrifuged remove impurity with tube centrifuge, when extracting solution after remove impurity is evaporated under conditions of 60 DEG C～70 DEG C 60 DEG C, relative density is the mastic of 1.20～1.23, and the mastic spray dryer after concentrating is dried to powder；
3rd step, is mixed surplus stock medical material in described ratio, adds the water soaking relative to 2～4 times of mixture quality obtained, and heating decocts 2～4 hours, filters；By filtering residue again with the water soaking of 1～2 times of the mixture quality relative to acquisition, heating decoction 1～2 hour, filter；Merging the filtrate of twice, concentrating under reduced pressure removes moisture, is dried and is ground into powder；
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the rubber relative to 1～2 times of described mixture of powders quality sum, the Colophonium of 1～2 times, mixing, make coating, carry out being coated with cream, cut off, lid lining, section, i.e. obtain described paster agent.
8. according to the pharmaceutical composition of the arbitrary described treatment fracture of shaft of femur of claim 1 to 6, it is characterised in that when the dosage form of described pharmaceutical composition is granule, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 85%～95% relative to mixture 4～8 times, it is heated to boiling reflux 3～5 hours, filter, use percolation with per minute 1～2ml speed slowly percolation, collect percolate, when being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa, relative density is the mastic of 1.04～1.10, it is spray-dried, the inlet temperature 160 of spray dryer～175 DEG C, leaving air temp 80～85 DEG C, be ground into powder subsequently, make dried cream powder；
Second step, adds relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times and the dextrin of 0.1～0.2 times in the dried cream powder obtained, makes granule, is dried in 40～50 DEG C, it is thus achieved that granule.
9. according to the pharmaceutical composition of the arbitrary described treatment fracture of shaft of femur of claim 1 to 6, it is characterised in that when the dosage form of described pharmaceutical composition is liniment, its preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, further pulverizes, crosses 100 mesh sieves, enables and is at least up to 40% by the fine powder amount of 100 mesh sieves, collects and obtains fine powder a by the fine powder of 100 mesh sieves；
Step 2: the coarse powder that will not pass through 100 mesh sieves puts into multi-function extractor extraction twice, adds weight portion 8-10 times amount soak by water 1-3 hour for the first time, and second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate；The heating of gained filtrate is concentrated into pasty state, and after putting into the drying of 80 DEG C of baking oven, room temperature cools down, and grinds to form fine powder b；
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
CN201610384922.6A 2016-06-02 2016-06-02 Pharmaceutical composition for the treatment of femoral shaft fracture and preparation method thereof Withdrawn CN105998512A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107854614A (en) * 2017-12-04 2018-03-30 曹建中 It is a kind of to be used to treat powder of soft tissue injury and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102274370A (en) * 2011-07-30 2011-12-14 支付亮 Traditional Chinese medicine composition for treating fracture
CN104784589A (en) * 2015-04-22 2015-07-22 袁娜 Medicinal composition for treating ankylosing spondylitis and preparation method of medicinal composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102274370A (en) * 2011-07-30 2011-12-14 支付亮 Traditional Chinese medicine composition for treating fracture
CN104784589A (en) * 2015-04-22 2015-07-22 袁娜 Medicinal composition for treating ankylosing spondylitis and preparation method of medicinal composition

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107854614A (en) * 2017-12-04 2018-03-30 曹建中 It is a kind of to be used to treat powder of soft tissue injury and preparation method thereof
CN107854614B (en) * 2017-12-04 2021-03-16 曹建中 Powder for treating soft tissue injury and preparation method thereof

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