CN104688932A - Traditional Chinese medicine preparation for postmenopausal osteoporosis and preparation method - Google Patents
Traditional Chinese medicine preparation for postmenopausal osteoporosis and preparation method Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for postmenopausal osteoporosis. Raw materials of the traditional Chinese medicine preparation comprise eucommia ulmoides, prepared rehmannia roots, epimedium brevicornum maxim, drynaria fortunei, cnidium monnieri, astragalus membranaceus, cuscuta chinensis lam, fructus lycii, angelica sinensis, paeonia lactiflora pallas, cornus officinalis, salvia miltiorrhiza bunge, peach kernels, carthamus tinctorius and achyranthes bidentata. According to different characteristics of traditional Chinese medicines, the raw materials are washed, diced and preprocessed and then prepared proportionally. The traditional Chinese medicine preparation is prepared through a special method and has the effects of tonifying the kidneys, growing bones, benefiting the liver, tonifying the spleen and promoting blood circulation to remove meridian obstruction. The combining and preparation method of the traditional Chinese medicine preparation is unique, and clinical verification shows that the traditional Chinese medicine preparation has a significant treatment effect, a short treatment period and low price, has no untoward effects or any toxic or side effects and has broad market application prospects.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for postmenopausal osteoporosis, the invention still further relates to the preparation method of this Chinese medicine preparation.
Background technology
Postmenopausal osteoporosis (postmenopause osteoporosis, PMOP) a kind of systemic skeletal disease becoming feature with Low BMD and osseous tissue micro structure degenerative disease that postmenopausal women occurs is referred to, belong to primary osteoporosis (osteoporosis, OP), clinical main manifestations is pain, stature change is short and fracture.The sickness rate of osteoporosis women is higher than male, and mainly concentrate in postmenopausal women, menopause is the important independent risk factor that osteoporosis occurs, osteoporosis in post-menopause women incidence of fracture is than high 2 times before menopause, more than 50 years old women's generation bones of the body joints, vertebra, the ratio of the position fracture such as extremities joint accounts for 400, 6, particularly vertebra and bones of the body articular fracture often can cause paralysis, there is very high fatality rate, disability rate also has a strong impact on life quality, after there are some researches show osteoporotic human bones fracture, 3, 6, 12, 24, 36, 60, 96, mortality rate after 120 months is respectively 10%, 14%, 18%, 27%, 32%, 45%, 55%, 68% [4].The high disability rate that postmenopausal osteoporosis and fracture thereof are brought and fatality rate bring heavy economy and manpower burden to society.So along with the arrival of aging society, the preventing and controlling of PMOP come into one's own all the more.
Current western medicine can slow down and control bone loss, but its side effect is many, expensive.And Chinese medicine osteoporosis low price, toxic and side effects is few, is convenient to patient's long-term taking.Traditional Chinese medical science scholar has made large quantity research in clinical and experiment in recent years, think that the mechanism of Chinese medicine osteoporosis is by the regulating action to body general, make patient's hypothalamus one hypophysis more than one target gland axle, and the disorder of the nervous system of plant and immunologic function recovers.In brief, Chinese medicine prevention osteoporosis is a kind of adjustment process to animal economy, acts on multiple link, thus reaches the effect of correcting body hormone imbalances and negative calcium balance effect.Therapeutic effect shows Chinese medicine and there is the dual function suppressing bone resorption and promoting bone growing.So Chinese medicine demonstrates its huge advantage gradually in treatment primary disease.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation being used for the treatment of postmenopausal osteoporosis, it is remarkable that this Chinese medicine preparation has therapeutic effect for treatment postmenopausal osteoporosis, and healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.
Inventor is in clinical treatment practice for many years, and according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out to be used for the treatment of the new formula of the Chinese medicine preparation of postmenopausal osteoporosis repeatedly.The present invention has that therapeutic effect is remarkable, and healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.
The effect of Chinese medicine of the present invention:
Wherein:
The Cortex Eucommiae: be the dry bark of Eucommiaceae plant Cortex Eucommiae Eucommia ulmoides Oliv..Nature and flavor: sweet, temperature.Return liver, kidney channel.Effect: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension.Record in " beautiful Chinese catalpa medicine solution ": liver and kidney tonifying, nourishing muscle and tendon bone, goes to joint to wet excessive.Control soreness of waist and knee joint, the contracture of lower limb foot.
Radix Rehmanniae Preparata: be the Preparation process product of Radix Rehmanniae.Nature and flavor: sweet, tepor.Return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.Record in " pearl sac ": enrich blood greatly empty not enough, promoting blood circulation, physical strength profiting.
Herba Epimedii: be the dry aerial parts of Berberidaceae plant Herba Epimedii Epimedium brevicornum Maxim., Epimedium sagittatum Epimedium sagittatum (Sieb.et Zucc.) Maxim., E. Pubescens Epimedium pubescens Maxim., Epimedium wushanense Epimedium wushanense T.S.Ying or Herba Epimedii Epimedium koreanum Nakai.Nature and flavor: acrid, sweet, warm.Return liver, kidney channel.Effect: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.Record in " not Lu ": hard muscles and bones.Disappear scrofula, red carbuncle; Skin ulcer is arranged at bottom, washes, and goes out worm.
Rhizoma Drynariae: be the dry rhizome of Plants of Polypodiaceae Mongolian oak Herba pteridii latiusculi Drynaria fortunei (Kunze) J. Sm..Nature and flavor: bitter, temperature.Return kidney, Liver Channel.Effect: the kidney invigorating bone strengthening, continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone; External treatment alopecia areata, vitiligo.Record in " Kaibao Bencao ": main removing blood stasis, hemostasis, benefit is traumaticd fracture.
Fructus Cnidii: be the dry mature fruit of samphire cnidium monnieri Cnidium monnieri (L.) Cuss..Nature and flavor: pungent, bitter, temperature; Slightly poisonous.Return kidney channel.Effect: warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus; Trichomonal vaginitis.Record in " herbal classic ": swell and ache in housewife people's the moon, man's impotence, pruritus due to damp pathogen, except stagnated QI, sharp joint, epilepsy, dislikes wound.
The Radix Astragali: be the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Nature and flavor: sweet, temperature.Return lung, spleen channel.Effect: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Semen Cuscutae: be the dry mature seed of convolvulus cuscuta plant Cuscuta chinensis Lam..Nature and flavor: sweet, temperature.Return liver,kidney,spleen warp.Effect: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.Record in " not Lu ": support flesh reinforcing YIN-essence, hard muscles and bones, stem invasion by pathogenic cold, essence is from going out, and drown and have the heeltap, bitter taste is yearningly dry, and cold blood is long-pending.
Fructus Lycii: be the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Nature and flavor: sweet are flat.Return liver, kidney channel.Effect: nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.Record in " Treatise on Dietetic Therapy ": hard muscle is always resistance to, except wind, tonification muscles and bones, the beneficial people of energy, removes asthenia.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor: sweet, acrid, warm.Return liver, the heart, spleen channel.Effect: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.Record in " not Lu ": warming middle-JIAO to relieve pain, fill in except in objective blood, middle puerperal tetanus, no sweating, arthralgia chiefly caused by damp pathogen, attacked by pestiferous factors is courteous, cold caused by deficiency, mend five and hide, granulation promoting meat.
The Radix Paeoniae Alba: be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor: bitter, sour, are slightly cold.Return liver, spleen channel.Effect: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.Record in " herbal classic ": main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, control cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating.
Fructus Corni: be the drying and ripening sarcocarp of Cornaceae plant Fructus Corni Cornus officinalis Sieb. et Zucc..Nature and flavor: sour, puckery, tepor.Return liver, kidney channel.Effect: liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed.Interior-heat is quenched one's thirst.Record in " property of medicine opinion ": control brain osteodynia, only moon water is indefinite, the kidney invigorating gas; Xing Yangdao, adds marrow, treats tinnitus, and except skin ulcer on face, the diaphoresis of main energy, only old man's urine does not save.
Radix Salviae Miltiorrhizae: be the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bunge..Nature and flavor: bitter, are slightly cold.GUIXIN, Liver Channel.Effect: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.Record in " the southern regions of the Yunnan Province book on Chinese herbal medicine ": reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful punching seized with terror, palpitation with fear is insomnia.
Semen Persicae: be the dry mature seed of rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana (Carr.) Franch..Nature and flavor: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Effect: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.For amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.Record in " herbal classic ": main blood stasis, blood closes lump in the abdomen, pathogen, kills small worm." not Lu ": only cough with dyspnea, disappear hardness in the epigastrium, and except soldier hits blood cruelly, broken lump in the abdomen, promotes blood circulation, pain relieving.
Flos Carthami: be the dried floral of feverfew Flos Carthami Carthamus tinctorius L..Nature and flavor: pungent, temperature.GUIXIN, Liver Channel.Effect: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache." detailed outline ": invigorate blood circulation, moisturizes, pain relieving, loose swollen, stimulates the menstrual flow.
Radix Achyranthis Bidentatae: be the dry root of amaranthaceous plant Radix Achyranthis Bidentatae Achyranthes bidentata Blume..Nature and flavor: bitter, sour are flat.Return liver, kidney channel.Effect: invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.Record in " Japan hanako materia medica ": control waist knee joint soft timid cold weak ， Po Disorder and tie, evacuation of pus pain relieving, puerperal cardiac and abdominal pain and blood transport, fall tire, tonifying YANG.
Side's solution of the present invention is: in side with the Cortex Eucommiae, Radix Rehmanniae Preparata for monarch drug, the Cortex Eucommiae is warm in nature, sweet in the mouth, returns Liver and kidney warp, can invigorating the liver and kidney, bone and muscle strengthening; The sweet Wen Zhirun of Radix Rehmanniae Preparata, yin nourishing of enriching blood, beneficial essence fills out marrow, Papillary, tonifying both YIN and YANG, and liver and kidney tonifying, strong muscle are good for bone.Herba Epimedii kidney invigorating and YANG supporting, remove rheumatism; The bitter temperature of Rhizoma Drynariae enters kidney, warming and recuperating the kidney-YANG, strengthening the tendons and bones, and continuous wound of invigorating blood circulation; Fructus Lycii nourishing the liver and kidney; Fructus Cnidii is warm in nature, acrid in the mouth, hardship, slightly poisonous, returns kidney channel, can warming the kidney to invigorate YANG, and normal and Radix Angelicae Sinensis, the Cortex Eucommiae, Fructus Lycii, Herba Epimedii compatibility play warming the kidney to invigorate YANG altogether; Fructus Corni tonifying liver nourishes blood, kidney tonifying arresting seminal emission; Semen Cuscutae is pungent to moisturize, sweet with tonify deficiency, is the product of flat nourishing YIN sun, kidney-replenishing, and kidney tonifying essence is ministerial drug altogether.Radix Angelicae Sinensis promoting blood flow to regulate menstruation, nourish blood tonifying liver, share common replenishing vital essence and blood with the product of the kidney invigorating; Radix Salviae Miltiorrhizae, Radix Paeoniae Alba nourshing blood and promoting blood circulation, stasis-dispelling and pain-killing; Semen Persicae, Flos Carthami blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain; Radix Astragali slightly warm in nature, sweet in the mouth, returns spleen lung meridian, can spleen invigorating invigorating middle warmer, ascending up spleen-Qi and Yang, tonification acquired essence is to nourish congenital essence, and the prosperous then blood of gas, match with blood circulation promoting medicine, benefiting QI for activating blood circulation, all medicines are adjuvant drug altogether, and this had both trained the benefit the source of vital function day after tomorrow to fill kidney essense, had again invigorating middle warmer to reside logical, the effect of tonify without causing stagnation.Radix Achyranthis Bidentatae returns Liver and kidney warp, invigorating the liver and kidney, bone and muscle strengthening, activating blood and promoting diuresis, has and can mend, and property is apt to descending feature, match with blood circulation promoting medicines such as Radix Angelicae Sinensis, the Radix Paeoniae Alba, Semen Persicae, Flos Carthamis, then conducting blood to flow downwards, blood circulation promoting and blood stasis dispelling, matches with the medicine of all liver and kidney tonifying, can priming return through, can blood circulation promoting and blood stasis dispelling, again can liver and kidney tonifying, strengthening the tendons and bones is for making medicine.Full side is total to the effect of tool kidney and bone health, the liver benefiting spleen invigorating, promoting blood circulation to remove obstruction in the collateral.Tonifying both YIN and YANG, giving consideration to both the incidental and fundamental, invigorating middle warmer residence is logical, and tonify without causing stagnation is its feature.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope: Cortex Eucommiae 10-14 gram, Radix Rehmanniae Preparata 10-14 gram, Herba Epimedii 7-11 gram, Rhizoma Drynariae 10-14 gram, Fructus Cnidii 10-14 gram, Radix Astragali 10-14 gram, Semen Cuscutae 7-11 gram, Fructus Lycii 7-11 gram, Radix Angelicae Sinensis 7-11 gram, Radix Paeoniae Alba 7-11 gram, Fructus Corni 7-11 gram, Radix Salviae Miltiorrhizae 7-11 gram, Semen Persicae 7-11 gram, Flos Carthami 4-8 gram, Radix Achyranthis Bidentatae 8-12 gram.
Wherein be preferably: the Cortex Eucommiae 12 grams, Radix Rehmanniae Preparata 12 grams, Herba Epimedii 9 grams, Rhizoma Drynariae 12 grams, Fructus Cnidii 12 grams, the Radix Astragali 12 grams, Semen Cuscutae 9 grams, Fructus Lycii 9 grams, Radix Angelicae Sinensis 9 grams, the Radix Paeoniae Alba 9 grams, Fructus Corni 9 grams, Radix Salviae Miltiorrhizae 9 grams, 9 grams, Semen Persicae, 6 grams, Flos Carthami, Radix Achyranthis Bidentatae 10 grams.
A kind of preparation method of the Chinese medicine preparation for postmenopausal osteoporosis is as follows:
Step one: by weight proportion of the present invention, first becomes medicated bag by Fructus Cnidii, Semen Cuscutae, Fructus Lycii, Fructus Corni, Semen Persicae bundle, is put in water and soaks 30-40 minute, filters, for subsequent use;
Step 2: by weight proportion of the present invention, grinds Radix Rehmanniae Preparata to 200 mesh sieves, for subsequent use;
Step 3: by weight proportion of the present invention, puts into after marmite adds step one immersion remain cold water by the Cortex Eucommiae, Radix Rehmanniae Preparata, Herba Epimedii, Rhizoma Drynariae, the Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, exceed powder 2 ~ 5 centimetres, after being fried boiling with high heat, then with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, in residue medicinal residues, add the water of 3 cm, then add the medicated bag slow fire boiling 20-30 minute in Flos Carthami and step one, obtain filtrate, merge twice filtrate, filter, waste, for subsequent use;
Step 4: by weight proportion of the present invention, adds the powder mix homogeneously in step 2 in the medicine soup in step 3, carried out by medicine soup concentrating adding ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, be the thick paste of relative density 1.15 ~ 1.20 under 75 DEG C of environment by gained concentration of liquid medicine, by air-dry for thick paste pulverizing, add Mel, antiseptic, wetting agent etc., carry out beating, rubbing, one-tenth ball, dry, be distributed into bag, both the honeyed pill for the treatment of postmenopausal osteoporosis of the present invention.
Medicine of the present invention has the effect of kidney and bone health, the liver benefiting spleen invigorating, promoting blood circulation to remove obstruction in the collateral, and it is effective, cheap, have no side effect, easy to use, the mode that this Chinese medicine preparation adopts is treated and can be reduced the injury of Western medicine to patient body, alleviates the slight illness of patient, according to clinical 120 routine patient view's statistics, use medicine total effective rate 86.67% of the present invention.
Detailed description of the invention
Embodiment one: the Cortex Eucommiae 12 grams, Radix Rehmanniae Preparata 12 grams, Herba Epimedii 9 grams, Rhizoma Drynariae 12 grams, Fructus Cnidii 12 grams, the Radix Astragali 12 grams, Semen Cuscutae 9 grams, Fructus Lycii 9 grams, Radix Angelicae Sinensis 9 grams, the Radix Paeoniae Alba 9 grams, Fructus Corni 9 grams, Radix Salviae Miltiorrhizae 9 grams, 9 grams, Semen Persicae, 6 grams, Flos Carthami, Radix Achyranthis Bidentatae 10 grams.
Embodiment two: the Cortex Eucommiae 13 grams, Radix Rehmanniae Preparata 11 grams, Herba Epimedii 10 grams, Rhizoma Drynariae 13 grams, Fructus Cnidii 12 grams, the Radix Astragali 12 grams, Semen Cuscutae 9 grams, Fructus Lycii 9 grams, Radix Angelicae Sinensis 9 grams, the Radix Paeoniae Alba 10 grams, Fructus Corni 8 grams, Radix Salviae Miltiorrhizae 8 grams, 10 grams, Semen Persicae, 7 grams, Flos Carthami, Radix Achyranthis Bidentatae 11 grams.
Embodiment three: the Cortex Eucommiae 11 grams, Radix Rehmanniae Preparata 11 grams, Herba Epimedii 10 grams, Rhizoma Drynariae 13 grams, Fructus Cnidii 13 grams, the Radix Astragali 11 grams, Semen Cuscutae 9 grams, Fructus Lycii 9 grams, Radix Angelicae Sinensis 9 grams, the Radix Paeoniae Alba 10 grams, Fructus Corni 10 grams, Radix Salviae Miltiorrhizae 10 grams, 8 grams, Semen Persicae, 5 grams, Flos Carthami, Radix Achyranthis Bidentatae 10 grams.
Here is the clinical statistics data that patient uses medicine of the present invention:
One, physical data
This research observation case is the patients with postmenopausal osteoporosis that in August, 2011 ~ these Out-patient Departments of in December, 2012 meet inclusive criteria, totally 120 examples, adopts Single-blind randomized control method observation case to be divided into treatment group 60 example, matched group 60 example.Medical history information and balance between the two groups analysis show, before treatment group and treatment of control group in age, menopause, height, body weight etc. through statistical analysis, difference there are no significant meaning (P>0. 05), has comparability.
Two, diagnostic criteria
1, postmenopausal osteoporosis: with reference to Liu Zhonghou [1] analysis by synthesis method standard: based on clinical manifestation and lab index, carries out comprehensive analysis in conjunction with bone density and makes a definite diagnosis.Chinese medical discrimination meets syndrome of deficiency of kidney-YANG standard with reference to " the dialectical reference standard of Chinese medicine deficiency-syndrome ".
2, clinical symptoms: back chronic pain is cardinal symptom.With reference to " the dialectical reference standard of Chinese medicine deficiency-syndrome " " syndrome of deficiency of kidney-YANG " dialectical standard.Cardinal symptom comprises soreness of the waist and knees, aversion to cold and cold limbs, nocturia, lazyness of breathing hard are made peace tired.
Three, Therapeutic Method:
1, matched group
Oral Rocaltrol 0.25ug/ sheet, 1 piece/times, 3 times/day; Take medicine continuously three courses for the treatment of, ten days course for the treatment of.
2, treatment group
Oral kidney and bone health granule 1/2 dose/time, 2 times/sooner or later, warm boiled water.Take medicine 3 courses for the treatment of, ten days course for the treatment of.
Four, efficacy assessment standard:
1, effective: breast lumbar and back pain disappears substantially, and functional activity is normal.
2, effective: breast lumbar and back pain alleviates, and functional activity is normal.
3, invalid: breast lumbar and back pain has no and alleviates, and functional activity has no improvement.
Five, therapeutic outcome statistics:
SPSS 13. 0 software is adopted to carry out statistical procedures.All data with
represent, compare before and after treatment and check with t.
1, clinical efficacy
Treat 1 month, after treatment group treatment, lumbar and back pain and functional activity are clearly better, and total effective rate 86.67%, compares with matched group (total effective rate 53.57%), difference significance.Show the pain that kidney and bone health granule better can be alleviated postmenopausal osteoporosis and causes, improve movable function.
Compare with matched group, P<0. O1
2, insufficiency of kidney-YANG symptom integral contrast before and after treatment
After treatment group treatment, every anomalous integral total mark obviously reduces, and compare with before treatment and after treatment of control group, difference all has significant (P<0. 05).
Represent and compare before treating with treatment group, compare before P<0. 05 treatment of control group, P<0. 05
3, before and after treatment, bone density, bone mineral content change are compared
After treatment, patient's bone density, bone mineral content index are all obviously improved, and compare with before treatment and after treatment of control group, difference all has significant (P<0. 05).
Compare before and after treatment group treatment, compare before and after P<0. 05 treatment of control group, P<0. 05
4, before and after treatment, skeleton metabolism compares
After treatment, patient E2. IL-6, urine Ca/Cr, skeleton metabolism such as urine Hop/Cr etc. all obviously improve, and compare with before treatment and after treatment of control group, difference all has significant (P<0. 05).
Compare before and after treatment group treatment, compare before and after P<0. 05 treatment of control group, P<0. 05
Treatment group compares with after treatment of control group, P<0. 05
Can find that observation group is apparently higher than matched group by the treatment total effective rate contrasting two groups of patients, illustrate thus, Chinese medicine of the present invention has good clinical effectiveness on treatment postmenopausal osteoporosis, effectively can improve the cure rate for the treatment of, Be very effective, cycle is short, without any side effects, has wide market application foreground.
Model case and curative effect:
Case one, patient Wang, female, 56 years old, people from Qingdao City.First visit on January 18 in 2012.Here diagnostic symptom is as follows: after menopause, frequent sclerotin is deteriorated, and leg joint part often occurs pain, occurs once fracturing.This symptom is postmenopausal osteoporosis.Adopt made preparation in the embodiment of the present invention one, and selected preparation method, after a course for the treatment of of treatment, effect is very good, and thoroughly cure after two courses for the treatment of, clinical symptoms disappears completely, and Effect of follow-up visit by telephone does not recur for 1 year.
Case two, patient Lee, female, 66 years old, people from Weifang, Shandong.Come here on May 14th, 2011 to go to a doctor, symptom is as follows after diagnosing: often fracture in leg joint.This symptom is postmenopausal osteoporosis.Adopt made preparation in the embodiment of the present invention one, and selected preparation method, after a course for the treatment of of treatment, effect is very good, and thoroughly cure after two courses for the treatment of, clinical symptoms disappears completely, and Effect of follow-up visit by telephone does not recur half a year.Family life becomes harmonious, and the date passes flourishing.
Claims (4)
1. the Chinese medicine preparation for postmenopausal osteoporosis, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Cortex Eucommiae 10-14 gram, Radix Rehmanniae Preparata 10-14 gram, Herba Epimedii 7-11 gram, Rhizoma Drynariae 10-14 gram, Fructus Cnidii 10-14 gram, Radix Astragali 10-14 gram, Semen Cuscutae 7-11 gram, Fructus Lycii 7-11 gram, Radix Angelicae Sinensis 7-11 gram, Radix Paeoniae Alba 7-11 gram, Fructus Corni 7-11 gram, Radix Salviae Miltiorrhizae 7-11 gram, Semen Persicae 7-11 gram, Flos Carthami 4-8 gram, Radix Achyranthis Bidentatae 8-12 gram.
2. a kind of Chinese medicine preparation for postmenopausal osteoporosis according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: the Cortex Eucommiae 12 grams, Radix Rehmanniae Preparata 12 grams, Herba Epimedii 9 grams, Rhizoma Drynariae 12 grams, Fructus Cnidii 12 grams, the Radix Astragali 12 grams, Semen Cuscutae 9 grams, Fructus Lycii 9 grams, Radix Angelicae Sinensis 9 grams, the Radix Paeoniae Alba 9 grams, Fructus Corni 9 grams, Radix Salviae Miltiorrhizae 9 grams, 9 grams, Semen Persicae, 6 grams, Flos Carthami, Radix Achyranthis Bidentatae 10 grams.
3. a kind of Chinese medicine preparation for postmenopausal osteoporosis according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is oral administration pills.
4. the preparation method for the Chinese medicine preparation of postmenopausal osteoporosis, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, first Fructus Cnidii, Semen Cuscutae, Fructus Lycii, Fructus Corni, Semen Persicae bundle are become medicated bag, be put in water and soak 30-40 minute, filter, for subsequent use; Step 2: by weight proportion of the present invention, grinds Radix Rehmanniae Preparata to 200 mesh sieves, for subsequent use; Step 3: by weight proportion of the present invention, puts into after marmite adds step one immersion remain cold water by the Cortex Eucommiae, Radix Rehmanniae Preparata, Herba Epimedii, Rhizoma Drynariae, the Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, exceed powder 2 ~ 5 centimetres, after being fried boiling with high heat, then with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, in residue medicinal residues, add the water of 3 cm, then add the medicated bag slow fire boiling 20-30 minute in Flos Carthami and step one, obtain filtrate, merge twice filtrate, filter, waste, for subsequent use; Step 4: by weight proportion of the present invention, adds the powder mix homogeneously in step 2 in the medicine soup in step 3, carried out by medicine soup concentrating adding ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, be the thick paste of relative density 1.15 ~ 1.20 under 75 DEG C of environment by gained concentration of liquid medicine, by air-dry for thick paste pulverizing, add Mel, antiseptic, wetting agent etc., carry out beating, rubbing, one-tenth ball, dry, be distributed into bag, both the honeyed pill for the treatment of postmenopausal osteoporosis of the present invention.
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| CN105193969A (en) * | 2015-10-08 | 2015-12-30 | 林素霞 | Medicine for treating postmenopausal osteoporosis |
| CN106309850A (en) * | 2016-11-15 | 2017-01-11 | 龙岩市中医院 | Soup for strengthening bone, activating blood and treating osteoporosis |
| RU2657789C1 (en) * | 2017-03-20 | 2018-06-15 | Федеральное Государственное бюджетное образовательное учреждение высшего образования Дагестанский государственный медицинский университет Министерства здравоохранения Российской Федерации | Method of treatment of osteoporosis in women in postmenopause against the background of obesity |
| DE102018111325A1 (en) * | 2018-05-11 | 2019-11-14 | Shanghai Boling Man Cosmetic CO., LTD | A medicine for the treatment of osteoporosis and a process for its production |
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| DE102018111325A1 (en) * | 2018-05-11 | 2019-11-14 | Shanghai Boling Man Cosmetic CO., LTD | A medicine for the treatment of osteoporosis and a process for its production |
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Application publication date: 20150610 |