CN104721644A - Traditional Chinese medicine preparation for knee osteoarthritis and preparation method of traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine preparation for knee osteoarthritis and preparation method of traditional Chinese medicine preparation Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for knee osteoarthritis. The traditional Chinese medicine preparation is prepared from the following raw materials: radix rehmanniae praeparata, dogwood, loranthus parasiticus, Chinese yam, poria cocos, raw coix seed, eucommia ulmoides, deer-horn glue, achyranthes bidentata, rhizoma drynariae, cynomorium songaricum, morinda officinalis, fried rhizoma atractylodis macrocephalae, zaocys dhumnade, long-noded pit viper, cassia twig, divaricate saposhnikovia root, asarum sieboldii, gentiana macrophylla, radix clematidis, radix aconiti preparata and radix liquiritiae at a certain weight ratio. The traditional Chinese medicine preparation has the efficacies of tonifying the liver and kidneys, strengthening tendons and bones, boosting essence and filling marrow, and is significant in curative effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for knee joint osseous arthritis, the invention still further relates to the preparation method of this Chinese medicine preparation.
Background technology
Knee joint osseous arthritis refers to due to knee cartilage degeneration, hyperosteogeny and the chronic osteoarthrosis illness of one caused, main manifestations is that arthralgia and activity are dumb, and x-ray performance joint space narrows, and subchondral bone matter is fine and close, bone trabecula ruptures, and has sclerosis and cystis degeneration.Be also called gonarthrosis, degenerative osteoarthritis and osseous arthritis etc.Primary disease is multiple is born in middle-aged and elderly people, also can betide adolescence, can one-sidedly fall ill, also can bilateral morbidity.The cause of disease of knee joint osseous arthritis is main: 1, bear a heavy burden for a long time.Long-term posture is bad, and bear a heavy burden firmly, overweight, causes knee joint soft tissue injury.2, chronic strain.Frequent knee joint injury, as the damage of fracture, cartilage, ligament.3, inherited genetic factors.Not agnate joint involvement situation is different, and sex also has impact, and primary disease is more common in women.When clinical main manifestations is knee articulation, pain increases the weight of, and being characterized in that from the beginning of pain be paroxysmal, is persistence afterwards, and fatigue and night, more very stair activity pain was obvious.Knee articulation is limited, very then walks lamely.Interlocking phenomenon or knee joint-effusion can be there is in only a few patient.Snap, crunch can be had, some patients arthroncus, with the passing of time visible joint deformity during joint motion.
Knee joint osseous arthritis belongs to Chinese medical ' arthralgia syndrome ' scope, Chinese medicine thinks that the knee joint osseous arthritis cause of disease is caused by body deficiency of both the liver and kidney, long-term strain, affection of exogenous wind-cold heresy, kidney governing bones, liver governing tendons, caused by liver and kidney deficiency then can not nourishing bone, and long-term strain and wound can form primary disease; Caused by liver and kidney deficiency, muscles and bones mistake are supported, to hinder meridians be that the pathogenesis of this illness is basic for long-term strain, qi depression to blood stasis, wind-cold damp pathogen numbness.Synovial membrane damages, water seepage liquid, and damp is detained.
At present, the Therapeutic Method of knee joint osseous arthritis is divided into two large classes generally: one is surgical intervention, total knee replacement the knee joint of disease damage partly or entirely replaced by made joint component by operation, that the articular surface of wear-out failure is excised, as dress facing, implantable artificial joint, makes it recover normally level and smooth articular surface.Two is expectant treatments, comprises medicine and rehabilitation, comprises physical therapy, medicine, injection treatment.Expenses of surgical treatment is high, and process is complicated, and even can be in peril of one's life, most people can not select operative treatment.Although energy alleviating pain in expectant treatment, can not delay disease process, long-term effect is poor; These medicines easily repeatedly, bring great misery to patient.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation for knee joint osseous arthritis, it is good that this Chinese medicine preparation has therapeutic effect for knee joint osseous arthritis, not easily recurs, cheap, has no side effect, the feature that healing time is short.
Another object of the present invention is to provide the preparation method of the Chinese medicine preparation of this treatment knee joint osseous arthritis.
Inventor is in clinical treatment practice for many years, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula of the Chinese medicine preparation for knee joint osseous arthritis repeatedly, the present invention selects Radix Rehmanniae Preparata, Fructus Corni, Herba Taxilli, Rhizoma Dioscoreae, Poria, Semen Coicis, the Cortex Eucommiae, Colla cornus cervi, Radix Achyranthis Bidentatae, Rhizoma Drynariae, Herba Cynomorii, Radix Morindae Officinalis, Rhizoma Atractylodis Macrocephalae (parched), Zaocys, Agkistrodon, Ramulus Cinnamomi, Radix Saposhnikoviae, Herba Asari, Radix Gentianae Macrophyllae, Radix Clematidis, Radix Aconiti Preparata, Radix Glycyrrhizae Preparata combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is liver and kidney tonifying, bone and muscle strengthening, benefit essence is filled out effect of marrow thus effectively can treat knee joint osseous arthritis.
The effect of Chinese medicine of the present invention:
Wherein:
Radix Rehmanniae Preparata: be scrophulariaceae rehmannia glutinosa plant (Rehmannia glutinosa(Gdertn) Iibosch.ex Fisch. et Mey.) tuber form through Processing methods.Nature and flavor: sweet, tepor.Return liver, kidney channel.Effect: nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.Radix Rehmanniae Preparata can be enriched blood YIN nourishing and liver-nourishing kidney-boosting, and all blood deficiency the moon loses, dizzy caused by deficiency of the liver and kindey, all can apply.This product nourishing kidney tonifying YIN, is applicable to the various diseases caused by deficiency of kidney yin, and the normal and compatibility such as Fructus Corni, Cortex Moutan is applied.
Fructus Corni: be the drying and ripening sarcocarp of Cornaceae plant Fructus Corni Cornus officinalis Sieb. et Zucc..Nature and flavor: sour, puckery, tepor.Return liver, kidney channel.Effect: liver and kidney tonifying, essence astringing and desertion stemming.Cure mainly and have a dizzy spell, deafness and tinnitus, soreness of the waist and knees, emission and spermatorrhea, frequent micturition, incessant sweating due to debility, woman uterine bleeding.Fructus Corni tepor is not dry, mends and not high, can flat nourishing YIN sun, supports the flourish muscle of marrow, by treating the liver kidney deficiency is commonly used.As the shenqi pill in " Medical Treasures of the Golden Chamber ".If empty with Liver and kidney element, the sense of soreness of waist flaccidity of the lower limbs be author, and Fructus Corni is normal with the same use of the medicine such as the Cortex Eucommiae, Radix Achyranthis Bidentatae, with invigorating the liver and kidney, and foster marrow honor muscle, and bone and muscle strengthening.
Herba Taxilli: be the dry stem and branch with leaf of Loranthaceae plant Herba Taxilli Taxillus chinensis (DC.) Danser.Nature and flavor: bitter, sweet, flat.Return liver, kidney channel.Effect: invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit, Herba Taxilli energy wind-damp dispelling, the meridian dredging, is apt to control numb limbs and tense tendons pain, to the rheumatalgia Be very effective of lower limb, Herba Taxilli invigorating the liver and kidney, bone and muscle strengthening, the profit that nourishes blood muscle.Its effect makes evil card be unlikely too to walk to alter, and is suitable for body wind syndrome caused by deficiency pain of dampness syndrome person, can control that blood deficiency rheumatic arthralgia, podomere are unfavorable, pain is gone here and there on the whole body.
Rhizoma Dioscoreae: be the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb..Nature and flavor: flat, sweet.Return spleen, lung, kidney channel.Effect: spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Sweet the providing additional supplies of this product is oozed, and not only mends but also sharp, and effect is gentle, and property is flat and partially without cold and heat, is the key medicine of promoting diuresis to eliminate damp pathogen.Treatment water wet the edema of expert time, often join Rhizoma Alismatis, Polyporus.Poria decoct has obvious sedation." modality ": " cure mainly Ji Rou Shun muscle of throbbing with fear cautious, dizziness agitation is controlled on side." this product is by heart-spleen boosting and tranquilizing mind.Be used for deficiency of both the heart and spleen, the irritability of insufficiency of vital energy and blood.
Semen Coicis: be the dry mature kernal of grass Semen Coicis Coix lacryma-jobi L. var. ma-yuen (Roman.) Stapf.Nature and flavor: sweet, light, cool.Return spleen, stomach, lung meridian.Effect: spleen invigorating eliminating dampness by diuresis, eliminating impediment pain relieving, clearing away heat and discharging pus.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.This product can eliminating dampness by diuresis, again can relaxing muscles and tendons arteries and veins, and slow contraction is anxious, is good at the damp dispelling muscle muscles and bones, therefore is used for arthralgia chiefly caused by damp pathogen, because it is cool in nature, therefore be more suitable for for damp and hot arthralgia pain.
The Cortex Eucommiae: be the dry bark of the Eucommiaceae plant Cortex Eucommiae (Eucommia ulmoides Oliver).Nature and flavor: sweet, temperature.Return liver, kidney, stomach warp.Effect: liver and kidney tonifying, bone and muscle strengthening, Chong and Ren Meridians regulating, solid through antiabortive.Compendium of Material Medica: the Cortex Eucommiae, ancient prescription only knows nourishing kidney, and only Wang Haogu speech is Liver Channel edema caused by disorder of QI medicine, and profit liver is dry, and tonifying liver is empty, sends out former times people and does not send out also.Lid liver governing tendons, kidney governing bones, it is strong that kidney fills then bone, and liver is filled then muscle and is good for, and bends and stretches utilization, all belongs to muscle.
Colla cornus cervi: for Cornu Cervi is endured through decocting, concentrated the solid gum made.Nature and flavor: sweet, salty, temperature.Return kidney, Liver Channel.Effect: temperature compensation Liver and kidney, beneficial intensive culture blood.For sexual impotence spermatorrhea, the acid of waist knee joint is cold, asthenia weakness and emaciation, metrostaxis, and hematuria of having blood in stool, carbuncle of yin nature swells and ache." book on Chinese herbal medicine converges and says ": Colla cornus cervi, kidney-Yang invigorating, gas of enriching blood, spermatogenesis marrow, the medicine of warm muscles and bones also.The main damaging the spleen and stomach labor of front Gu is exhausted, lumbago weakness and emaciation, gas marrow muscles and bones the intestines and stomach of enriching blood.Treatment of deficiency-syndrome by reinforcement, damage person trains it, and exhausted person continues it, timid person strong it, cold person warms up it, and this is the essence of blood genuss, and comparatively vegetation is merciless, more increasing one power of raising.
Radix Achyranthis Bidentatae: be the root of Amaranthus mangostanus L. section herbaceos perennial Radix Achyranthis Bidentatae or RADIX CYATHULAE.Nature and flavor: bitter, sour, flat.Return liver, kidney channel.Effect: eliminating blood stasis and inducing menstruation, conducting blood to flow downwards, invigorating the liver and kidney, bone and muscle strengthening.Radix Achyranthis Bidentatae is apt to descending, as guiding drug, guides the efficacy of a drug of other medicines to come downwards to the lower part of the body, controls the inferior the illness of half body.Radix Achyranthis Bidentatae is partial to tonifying liver and kidney and strengthening bones and muscles.
Rhizoma Drynariae: be the dry rhizome of Plants of Polypodiaceae Mongolian oak Herba pteridii latiusculi Drynaria fortunei (Kunze) J. Sm..The whole year all can excavate, removing silt, dry, or burns remove floss (scale) again.Nature and flavor: bitter, temperature.Return kidney, Liver Channel.Effect: the kidney invigorating bone strengthening, continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone; External treatment alopecia areata, vitiligo.
Herba Cynomorii: be the dry meat stem of Cynomoriaceae plant Herba Cynomorii Cynomorium songaricum Rupr..Nature and flavor: sweet, temperature.Return spleen, kidney, large intestine channel.Effect: kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.Soft for waist knee joint flaccidity, sexual impotence spermatorrhea, dryness of the intestine constipation." book on Chinese herbal medicine is looked for the truth ": Herba Cynomorii, this is all a class with Herba Cistanches.All cloudy deficiency of vital energys are damaged, and essence and blood is decayed, constipation due to dry stool, control available this to eat, and for Herba Cistanches, cook congee Mi Jia, though then know its property temperature, its body still moistens, cannot not cloud be the medicine that must use of decline of the fire from the gate of life also.
Radix Morindae Officinalis: be the dry root of dicotyledon medicine Maguireothamnus speciosus Radix Morindae Officinalis Morinda officinalis How.Nature and flavor: pungent, sweet; Tepor.Return kidney channel, Liver Channel.Effect: reinforcing the kidney and supporting YANG, expelling wind and removing dampness, strengthening the tendons and bones.Muscles and bones flaccidity for deficiency of the liver and kindey is soft, lumbocrural pain often joins the Cortex Eucommiae etc., or rheumatism lingering arthralgia and the deficient person of Liver and kidney, often joins Radix Achyranthis Bidentatae etc.; This product can YANG invigorating benefit essence and bone and muscle strengthening, again can pungent temperature and except rheumatism, therefore deficiency of the liver and kindey has rheumatism and lumbocrural pain person concurrently, use the most suitable.
Rhizoma Atractylodis Macrocephalae (parched): be the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor: bitter, sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive, the Rhizoma Atractylodis Macrocephalae can air making-up and spleen enlivening, again can dampness diuretic, is the key medicine of the spleen strengthening and damp drying.To rule together asthenia, the weak person of overstrain.Rhizoma Atractylodis Macrocephalae antibacterial action is obvious: infusion has inhibitory action to acrothesium floccosum, star nocardia in vitro.
Zaocys: be the dry body of Colubridae animal Zaocys Zaocys dhumnades (Cantor).Nature and flavor: sweet are flat.Return Liver Channel.Effect: dispel the wind, dredging collateral, relieving convulsion.For rheumatoid arthritis stubborn, numbness contracture, apoplexy facial hemiparalysis, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.
Agkistrodon: Agkistrodon Agkistrodonacutus(Gunther) the dry corpse of snakelet.Nature and flavor: sweet, salty, temperature; Poisonous.Return Liver Channel.Effect: dispel the wind, dredging collateral, relieving convulsion.For rheumatoid arthritis stubborn, numbness contracture, middle air port is askew, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.To the disease such as rheumatic arthralgia, spasm of muscles and vessels, can the medicine such as compatibility Radix Angelicae Pubescentis, Herba Taxilli with using.
Ramulus Cinnamomi: be the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Nature and flavor: acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Effect: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Cure mainly exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; WEIJIA is lumpd; The thoracic obstruction; Cardiopalmus; Phlegm retention.Ramulus Cinnamomi is warm in nature, and the kind gas that activates yang, can change YIN-cold, hold back resistance yang-energy to YIN-cold, and body fluid can not defeated cloth, the thus disease of retention of water-damp formation phlegm retention.This product energy promoting the flow of QI-blood by warming the meridian, dispersing cold for relieving pain, for all pain cards such as congealing cold with blood stasis.
Radix Saposhnikoviae: be the dry root of umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk..Nature and flavor: pungent, sweet, tepor.Return bladder, lung, spleen, Liver Channel.Effect: expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.For diseases caused by exogenous pathogenic factor exterior syndrome or rubella pruritus.This product slightly warm in nature and not dry, sweet slow and not high, there is the title of " the profit agent in wind medicine ", no matter wind and cold, wind heat exterior syndrome all can be applied.This product also can be used for tetanus, gnathospasma, opisthotonus.Radix Saposhnikoviae controls tetanus, has the effect of expellingging wind and relieving convulsion.
Herba Asari: be aristolochiaceae plant Herba Asari Asarum heterotropoides Fr. Schmidt var.mandshuricum(Maxim.) the dry herb of Kitag., Seoul Herba Asari Asarum sieboldii Miq. var. seoulense Nakai or magnificent Herba Asari Asarum sieboldii Miq..Nature and flavor: pungent; Temperature; Mild toxicity.Return lung meridian, kidney channel, heart channel, Liver Channel, gallbladder meridian, spleen channel.Effect: mass dissipating and swelling eliminating; Induce sweat cold expelling; Wind-expelling pain-stopping; Warming the lung to resolve fluid-retention; The therapeutic method to keep the adverse QI flowing downwards is eliminated the phlegm, sensible.The pungent perfume (or spice) of Herba Asari is walked to alter, and has good cold-dispelling, and the effect of the pain that relieves the pain, uses dispelling the wind and dampness pathogens arthralgia pain, the medicines such as the acid of waist knee joint is cold, Chang Peiwu Radix Angelicae Pubescentis.
Radix Gentianae Macrophyllae: be the dry root of gentianaceae plant Radix Gentianae Macrophyllae Gentiana macrophylla Pall., gentiana straminea maxim Gentiana straminea Maxim., gentiana crassicaulis Duthie Gentiana crassicaulis Duthie ex Burk. or Gentiana dahurica Gentiana dahurica Fisch..Nature and flavor: pungent, bitter, are slightly cold.Return stomach warp, Liver Channel, gallbladder meridian.Effect: Eradicates rheumatism, relaxing muscles and tendons network, clearind deficient heat, stopping numbness pain, " herbal classic " has cloud: " main cold and heat pathogen, cold-damp migratory arthralgia, arthrodynia of the extremities, lower water, diuresis." Radix Clematidis wind-damp dispelling, the meridian dredging; The pungent loose hardship of Radix Gentianae Macrophyllae is let out, and character peace is the profit agent in wind, and the wind that can fall apart dehumidifying, channels sootheing and network vessel quickening, partially control the inferior hemialgia, two medicine compatibilities, control chronic rheumatic arthritis, arthralgia, joint stuffiness, numb hand and foot.
Radix Clematidis: be the dry root and rhizome of ranunculaceae plant Radix Clematidis Clematis chinensis Osbeck, Clematis hexapetala (mountain knotweed) Clematis hexapetala Pall. or northeast clematis (black common vetch) Clematis manshurica Rupr..Nature and flavor: pungent, salty, temperature, poisonous.Return urinary bladder channel.Effect: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump.For rheumatic arthralgia, numb limbs and tense tendons, joint stuffiness.No matter all rheumatic arthralgia, apathy, all can use up and down, is rheumatic arthralgia key medicine, " medicineization justice " medium cloud: Radix Clematidis, and property is suddenly anxious, is apt to away and does not keep, the logical twelve channels and collaterals of a surname.Cure mainly wind, wet, expectorant stops up in stagnant meridians, cause into gout and walk through, arthralgia, or swollen, or numb.Modern study confirms, Radix Clematidis, containing Anemonin and Radix Pulsatillae alcohol, Saponin etc., has analgesia, antidiuretic activity.Vinegar immersion has certain emollescence to fish bony spur, and makes local of flaccid muscles, impels bony spur to come off.Decoct has obvious antibacterial action, all has comparatively high inhibition effect, play the effect of anti-inflammation to Gram-positive and negative bacterium, mycete, and antibacterial can not be made to produce drug resistance.
Radix Aconiti Preparata: be the Preparation process product of Radix Aconiti.Nature and flavor: pungent, bitter, heat; Poisonous.GUIXIN, liver,kidney,spleen warp.Effect: expelling wind and removing dampness, antalgic.For anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.
Radix Glycyrrhizae Preparata: be the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Radix Glycyrrhizae Preparata is that processed goods smoked by the honey of Radix Glycyrrhizae.Nature and flavor are sweet, flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery." Japan hanako materia medica ": peace soul determines soul.Mend five kinds of strain and seven kinds of impairment, all be deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle, separates cold and hot.
Side's solution of the present invention is: in side be Radix Rehmanniae Preparata nourishing YIN and supplementing blood, beneficial essence fills out marrow, Fructus Corni liver and kidney tonifying, essence astringing and desertion stemming, Herba Taxilli invigorating the liver and kidney, bone and muscle strengthening, Rhizoma Dioscoreae spleen reinforcing nourishing the stomach, the kidney invigorating arresting seminal emission, Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, the above five tastes are monarch drug altogether, first from the fundamentally invigorating the liver and kidney of patient with nourishing muscle and tendon bone, Poria promoting diuresis to eliminate damp pathogen simultaneously, eliminate hydrarthrosis phenomenon, carry out disease therapy from two aspects, fundamentally nurse one's health health, the development of tissue disease.Semen Coicis helps the pain relieving of Poria eliminating impediment, clearing away heat and discharging pus, Cortex Eucommiae liver and kidney tonifying, bone and muscle strengthening, and Colla cornus cervi, Radix Achyranthis Bidentatae, Rhizoma Drynariae three share temperature compensation Liver and kidney, Herba Cynomorii the kidney invigorating and essence nourishing, Radix Morindae Officinalis strengthening the tendons and bones, above seven tastes are ministerial drug altogether, increase the monarch drug efficacy of a drug, patient is recovered faster.Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and benefiting QI, dampness diuretic, Zaocys, Agkistrodon dispelling wind and removing obstruction in the collateral, Ramulus Cinnamomi promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, Radix Saposhnikoviae removing dampness to relieve pain, Herba Asari mass dissipating and swelling eliminating, Radix Gentianae Macrophyllae relaxing muscles and tendons and activating QI and blood in the collateral, Radix Clematidis expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, Radix Aconiti Preparata expelling wind and removing dampness, antalgic, above a few taste is adjuvant drug altogether, adds effect of meridians dredging, promote that being conducive to medicine arrives focus, promotes the recovery of patient.Radix Glycyrrhizae Preparata priming return through, coordinating the actions of various ingredients in a prescription, for making medicine.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, have liver and kidney tonifying, effect that bone and muscle strengthening, beneficial essence fill out marrow, effectively can treat knee joint osseous arthritis.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Rehmanniae Preparata 10-20 part, Fructus Corni 5-15 part, Herba Taxilli 13-23 part, Rhizoma Dioscoreae 7-17 part, Poria 7-17 part, Semen Coicis 10-20 part, Cortex Eucommiae 13-23 part, Colla cornus cervi 3-9 part, Radix Achyranthis Bidentatae 10-20 part, Rhizoma Drynariae 10-20 part, Herba Cynomorii 7-17 part, Radix Morindae Officinalis 7-17 part, Rhizoma Atractylodis Macrocephalae (parched) 10-20 part, Zaocys 4-14 part, Agkistrodon 4-14 part, Ramulus Cinnamomi 7-17 part, Radix Saposhnikoviae 5-15 part, Herba Asari 1-5 part, Radix Gentianae Macrophyllae 13-23 part, Radix Clematidis 13-23 part, Radix Aconiti Preparata 3-9 part, Radix Glycyrrhizae Preparata 3-9 part.
Wherein be preferably: Radix Rehmanniae Preparata 15 parts, Fructus Corni 10 parts, Herba Taxilli 18 parts, Rhizoma Dioscoreae 12 parts, 12 parts, Poria, Semen Coicis 15 parts, the Cortex Eucommiae 18 parts, Colla cornus cervi 6 parts, Radix Achyranthis Bidentatae 15 parts, Rhizoma Drynariae 15 parts, Herba Cynomorii 12 parts, Radix Morindae Officinalis 12 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, Zaocys 9 parts, Agkistrodon 9 parts, Ramulus Cinnamomi 12 parts, Radix Saposhnikoviae 10 parts, Herba Asari 3 parts, Radix Gentianae Macrophyllae 18 parts, Radix Clematidis 18 parts, Radix Aconiti Preparata 6 parts, Radix Glycyrrhizae Preparata 6 parts.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.Such as these crude drug pulverize mix homogeneously can be made powder to take after mixing it with water; Can decocting be used, obtain filtrate after filtration, add antiseptic and make oral liquid; Also directly decoction can be taken if desired.
The preferred preparation method of the present invention is decoction, and its preparation method is as follows:
Step one: by weight proportion of the present invention, takes Fructus Corni, Rhizoma Dioscoreae, Semen Coicis is bundled into medicated bag, for subsequent use;
Step 2: by weight proportion of the present invention, take Radix Aconiti Preparata and put into marmite, add water and cover medicine 5-6 centimetre, first with high heat that water is boiled, then slow fire is transferred to, decoct 0.5 hour, then Radix Rehmanniae Preparata is added, Radix Achyranthis Bidentatae, Rhizoma Drynariae, Radix Morindae Officinalis, Rhizoma Atractylodis Macrocephalae (parched), Radix Saposhnikoviae, Radix Gentianae Macrophyllae, Radix Clematidis is put into pot and is continued to decoct 30-40 minute, filter, obtain filtrate, in residue medicinal residues, add the water of 3-4 centimetre, boiled, then Herba Taxilli is added, the Cortex Eucommiae, Herba Cynomorii, Zaocys, Agkistrodon, Ramulus Cinnamomi, Herba Asari, Radix Glycyrrhizae Preparata, and the medicated bag in step one decocts 30 minutes, filter, obtain filtrate, for subsequent use,
Step 3: by weight proportion of the present invention, takes Poria and grinds to 180 mesh sieves, for subsequent use;
Step 4: twice medicinal liquid in step 2 is merged, the powder in step 3 is joined in medicinal liquid, mix homogeneously, and Colla cornus cervi is put into while hot medicine soup molten, both the decoction for the treatment of knee joint osseous arthritis of the present invention.
Effect that medicine of the present invention has liver and kidney tonifying, bone and muscle strengthening, beneficial essence fill out marrow, and therapeutic effect is good, not easily recur, cheap, have no side effect, healing time is short, adds up according to clinical 165 routine patient view, use medicine of the present invention the total effective rate course for the treatment of 90.4%, two the total effective rate course for the treatment of 97.6%.
Detailed description of the invention
Embodiment one, Radix Rehmanniae Preparata 10 parts, Fructus Corni 5 parts, Herba Taxilli 13 parts, Rhizoma Dioscoreae 7 parts, 7 parts, Poria, Semen Coicis 10 parts, the Cortex Eucommiae 13 parts, Colla cornus cervi 3 parts, Radix Achyranthis Bidentatae 10 parts, Rhizoma Drynariae 10 parts, Herba Cynomorii 7 parts, Radix Morindae Officinalis 7 parts, Rhizoma Atractylodis Macrocephalae (parched) 10 parts, Zaocys 4 parts, Agkistrodon 4 parts, Ramulus Cinnamomi 7 parts, Radix Saposhnikoviae 5 parts, Herba Asari 1 part, Radix Gentianae Macrophyllae 13 parts, Radix Clematidis 13 parts, Radix Aconiti Preparata 3 parts, Radix Glycyrrhizae Preparata 3 parts.
Embodiment two, Radix Rehmanniae Preparata 15 parts, Fructus Corni 10 parts, Herba Taxilli 18 parts, Rhizoma Dioscoreae 12 parts, 12 parts, Poria, Semen Coicis 15 parts, the Cortex Eucommiae 18 parts, Colla cornus cervi 6 parts, Radix Achyranthis Bidentatae 15 parts, Rhizoma Drynariae 15 parts, Herba Cynomorii 12 parts, Radix Morindae Officinalis 12 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, Zaocys 9 parts, Agkistrodon 9 parts, Ramulus Cinnamomi 12 parts, Radix Saposhnikoviae 10 parts, Herba Asari 3 parts, Radix Gentianae Macrophyllae 18 parts, Radix Clematidis 18 parts, Radix Aconiti Preparata 6 parts, Radix Glycyrrhizae Preparata 6 parts.
Embodiment three, Radix Rehmanniae Preparata 20 parts, Fructus Corni 15 parts, Herba Taxilli 23 parts, Rhizoma Dioscoreae 17 parts, 17 parts, Poria, Semen Coicis 20 parts, the Cortex Eucommiae 23 parts, Colla cornus cervi 9 parts, Radix Achyranthis Bidentatae 20 parts, Rhizoma Drynariae 20 parts, Herba Cynomorii 17 parts, Radix Morindae Officinalis 17 parts, Rhizoma Atractylodis Macrocephalae (parched) 20 parts, Zaocys 14 parts, Agkistrodon 14 parts, Ramulus Cinnamomi 17 parts, Radix Saposhnikoviae 15 parts, Herba Asari 5 parts, Radix Gentianae Macrophyllae 23 parts, Radix Clematidis 23 parts, Radix Aconiti Preparata 9 parts, Radix Glycyrrhizae Preparata 9 parts.
Here is the clinical statistics data that patient uses medicine of the present invention:
One, physical data
Treat knee osteoarthritis patients 330 example a year May in October, 2011 to 2014.Patient is divided into observation group and matched group at random, wherein male 118 example, women 130 example, M-F 1:1.1, max age 81 years old, minimal ages 40 years old, the course of disease time is not etc., every basic documents such as two groups of patient ages, sex, courses of disease are substantially identical, no significant difference (P > 0.05).
Two, Therapeutic Method:
1, according to Medications Example two of the present invention, and preparation prepared by selected preparation method, every day potion, one day twice 7th is a course for the treatment of.
2, matched group adopts conventional therapy to treat, and is an observation cycle with 7 days.
Three, efficacy assessment standard:
1, cure: transference cure, joint movement function recovers normal, and without arthroncus, stair activity is without pain, and local is without tenderness, and joint motion is without bony crepitus, stiff without obvious morning;
2, take a turn for the better: symptom alleviates, joint movement function still can, joint not enlargement pain, stair activity is slightly uncomfortable, without bony crepitus when joint is moved, stiff without obvious morning, tibia medial epicondyle or the light tenderness of patella;
3, do not heal: symptom, sign are unchanged, joint movement function is without improvement, and stair activity, arthroncus, local tenderness, morning are stiff etc. without changing.
Four, observation group's result statistics
Matched group result is added up
Wherein: total effective rate=cure rate+improvement rate
Use the Comparison of therapeutic situation of this Chinese medicine preparation two groups of patients, two courses for the treatment of
Can find that observation group is apparently higher than matched group by the treatment total effective rate contrasting two groups of patients, illustrate thus, Chinese medicine of the present invention has good clinical effectiveness at treatment knee joint osseous arthritis, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.
Model case and curative effect:
Case one, patient neat certain, female, 55 years old, left side gonalgia half a year, movable difficulty, joint stuffiness, overcast and rainy or weather turns cold time increase the weight of, and with tingle sense, examination in hospital knee joint place obvious tumefaction, x-ray performance joint space narrows, and with the phenomenon of hardening, confirm as knee joint osseous arthritis, after hospitalize, pain symptom alleviates, drug withdrawal was recurred after one month, went to a doctor in here afterwards, adopt made preparation in the embodiment of the present invention two, and selected preparation method, after patient uses a course for the treatment of, pain obviously alleviates, adhere to again employing two courses for the treatment of, knee articulation freely, tingle sense disappears, work housework is all nothing difficult, recurrence is had no after drug withdrawal, recovery from illness.
Case two, patient Zhang, female, 59 years old, nearly 2 years of two knee joint place dull pain, nearest pain increases the weight of, can not take care of oneself time serious, movable critical constraints, through examination in hospital, the fine and close phenomenon of subchondral bone matter is serious, be diagnosed as knee joint osseous arthritis, patient wishes to adopt Chinese traditional treatment method, here treatment afterwards, adopt made preparation in the embodiment of the present invention two, after using two courses for the treatment of, patient gently presses joint pain obviously to alleviate, some light and handy housework can be done at home, continue a course for the treatment of of use, patient's knee joint place bends and stretches effectively, activity freely, pain disappears, observe and have no recurrence half a year, recovery from illness.
Case three, patient Meng, man, 68 years old, the gonalgia, activity is slightly limited, walking disorder, and there is difficulty of squatting down, go examination in hospital to be diagnosed as knee joint osseous arthritis, patient adopts made preparation in the embodiment of the present invention two, after using a course for the treatment of, the limited phenomenon of patient's knee articulation obviously alleviates, and the phenomenon of pressing pain also takes a turn for the better to some extent, patient continues two courses for the treatment of of use, and pain disappears completely, and activity freely, follow up a case by regular visits to half a year, do not recur, recovery from illness.
Claims (4)
1. the Chinese medicine preparation for knee joint osseous arthritis, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Radix Rehmanniae Preparata 10-20 part, Fructus Corni 5-15 part, Herba Taxilli 13-23 part, Rhizoma Dioscoreae 7-17 part, Poria 7-17 part, Semen Coicis 10-20 part, Cortex Eucommiae 13-23 part, Colla cornus cervi 3-9 part, Radix Achyranthis Bidentatae 10-20 part, Rhizoma Drynariae 10-20 part, Herba Cynomorii 7-17 part, Radix Morindae Officinalis 7-17 part, Rhizoma Atractylodis Macrocephalae (parched) 10-20 part, Zaocys 4-14 part, Agkistrodon 4-14 part, Ramulus Cinnamomi 7-17 part, Radix Saposhnikoviae 5-15 part, Herba Asari 1-5 part, Radix Gentianae Macrophyllae 13-23 part, Radix Clematidis 13-23 part, Radix Aconiti Preparata 3-9 part, Radix Glycyrrhizae Preparata 3-9 part.
2. the Chinese medicine preparation for knee joint osseous arthritis according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Radix Rehmanniae Preparata 15 parts, Fructus Corni 10 parts, Herba Taxilli 18 parts, Rhizoma Dioscoreae 12 parts, 12 parts, Poria, Semen Coicis 15 parts, the Cortex Eucommiae 18 parts, Colla cornus cervi 6 parts, Radix Achyranthis Bidentatae 15 parts, Rhizoma Drynariae 15 parts, Herba Cynomorii 12 parts, Radix Morindae Officinalis 12 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, Zaocys 9 parts, Agkistrodon 9 parts, Ramulus Cinnamomi 12 parts, Radix Saposhnikoviae 10 parts, Herba Asari 3 parts, Radix Gentianae Macrophyllae 18 parts, Radix Clematidis 18 parts, Radix Aconiti Preparata 6 parts, Radix Glycyrrhizae Preparata 6 parts.
3. the Chinese medicine preparation for knee joint osseous arthritis according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is decoction.
4. for a preparation method for the Chinese medicine preparation of knee joint osseous arthritis, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, takes Fructus Corni, Rhizoma Dioscoreae, Semen Coicis be bundled into medicated bag, for subsequent use, step 2: by weight proportion of the present invention, take Radix Aconiti Preparata and put into marmite, add water and cover medicine 5-6 centimetre, first with high heat that water is boiled, then slow fire is transferred to, decoct 0.5 hour, then Radix Rehmanniae Preparata is added, Radix Achyranthis Bidentatae, Rhizoma Drynariae, Radix Morindae Officinalis, Rhizoma Atractylodis Macrocephalae (parched), Radix Saposhnikoviae, Radix Gentianae Macrophyllae, Radix Clematidis is put into pot and is continued to decoct 30-40 minute, filter, obtain filtrate, in residue medicinal residues, add the water of 3-4 centimetre, boiled, then Herba Taxilli is added, the Cortex Eucommiae, Herba Cynomorii, Zaocys, Agkistrodon, Ramulus Cinnamomi, Herba Asari, Radix Glycyrrhizae Preparata, and the medicated bag in step one decocts 30 minutes, filter, obtain filtrate, for subsequent use, step 3: by weight proportion of the present invention, takes Poria and grinds to 180 mesh sieves, for subsequent use, step 4: twice medicinal liquid in step 2 is merged, the powder in step 3 is joined in medicinal liquid, mix homogeneously, and Colla cornus cervi is put into while hot medicine soup molten, both the decoction for the treatment of knee joint osseous arthritis of the present invention.
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