CN105031441A - Medicine for treating ankylosing spondylitis and preparation method of medicine - Google Patents

Abstract

The invention discloses a medicine for treating ankylosing spondylitis and a preparation method of the medicine. The medicine comprises various active pharmaceutical ingredient as follows: herb of rice galingale, cassia bark, boxthorn fruit, cortex lycii radicis, arthraxon hispidus, rubia tinctorum madder root, corydalis cheilanthifolia, cattail pollen, cassia twig, radix rhapontici, Szechuan lovage rhizome, berchemia lineata, whitebracteole bugle herb, root or stem of evergreen mucuna, jamaica falsevalerian herb, rhizoma sparganii, tripterospermum volubile, falcate dolichos root or leaf, common pratia herb, diversifolious patrinia root, irid, smilacina japonica, teasel root, fructus leonuri, achyranthes bidentata, homalomena occulta and common clubmoss herb. The medicine has the efficacies of nourishing the liver and kidney, dispelling wind to eliminate dampness, and strengthening muscles and bones, together with the functions of dredging collaterals and activating blood circulation to remove blood stasis, and has the advantages of being instant in effect, high in effective rate, exact in treatment effect, short in treatment course, free of toxic or side effect, and low in price.

Description

A kind of medicine for the treatment of ankylosing spondylitis and preparation method thereof

Technical field

The present invention relates to technical field of medicine, particularly a kind of medicine for the treatment of ankylosing spondylitis and preparation method thereof.

Background technology

Ankylosing spondylitis (ankylosingsporidylitis, AS) be the common disease of orthopaedics, Rheumatism Dept., with sacroiliac joint and spinal column attachment point inflammation for cardinal symptom, with annulus fibrosus disci intervertebralis and neighbouring connective fiberization thereof and ossified, and ankylosis is lesion characteristic, belong to autoimmune disease.There is inflammatory pain in joint, early lesion place, and with periarticular muscles spasm, have stiff sense, morning rises obviously.Also pain at night can be shown as, through movable or take analgesic and alleviate.Along with PD, arthralgia alleviates, and each spinal column segment and joint motion limited and lopsided, late period whole spinal column and lower limb become stiff arc, to pre-buckling.

The symptom and sign of ankylosing spondylitis: with Enthesitis, refer to/dactylitis or pauciarthritis onset, some cases can develop into sacroiliitis and spondylitis, with or without extra-articular manifestations such as acute anterior uveitis or skin mucosa infringements.Tendon initiating terminal inflammation, occurs in calcaneus periostitis and Achilles Tendonitis, tibial tubercle and other positions, and in the clinical infection often lacking obvious inflammatory bowel, psoriasis or intestinal or urogenital tract.Position, tendon end is subject to lymphocyte, plasma cell and polymorphonuclear leukocyte infiltration, and the medullary cavity near it also occurs edema and infiltrated.The distinguishing feature of ankylosing spondylitis is, wherein, and the high rate of axial musculature end inflammation and synovitis, and finally cause the fibrosis of sacroiliac joint and spinal column and the bony ankylosis in late period.

Ankylosing spondylitis prevention nursing: ankylosing spondylitis have certain hereditary basis, the traditional Chinese medical science thinks that the morbidity of ankylosing spondylitis arises from natural endowment deficiency or imbalance of taking good care of oneself the day after tomorrow, sexual overstrain, terrified, disgruntled, after being ill imbalance etc., then caused by liver and kidney deficiency is caused, in addition wind-cold damp pathogen and falling ill, therefore following several respects should be noted.1. strengthen physical exercise, reasonable life rule, keep the mood of happiness to improve human body immune function.2. avoid the invasion and attack of wind-cold damp pathogen, preventing cold and infection.3. wine for giving off smoking, notes maintaining normal posture and mobility.

The medical diagnosis on disease of ankylosing spondylitis: 1. lumbosacral joint strain: chronic lumbosacral joint strain is persistence, diffusivity lumbago, and the heaviest with lumbosacral region, spinal motion is not limited, and x-ray is without special change.Acute lumbosacral joint strain, pain increases the weight of because of movable, can alleviate after rest.2. osteoarthritis: often betide old people, be characterized as skeleton and cartilage degeneration, synovial membrane thickens, more common with the spinal column born a heavy burden and knee joint etc.Person take often chronic low back pain as cardinal symptom to involve vertebra, easily obscures with ankylosing spondylitis; But ankylosis and amyotrophy do not occur, and without General Symptoms, x-ray shows as hyperosteogeny and generates and narrowing of intervertebral space.3.Forestier is sick: the spinal column of Forestier patient also forms seriality hyperosteogeny, and the spinal column ring sample of similar ankylosing spondylitis becomes, but sacroiliac joint is normal, and Facet joint is inviolable.4. tuberculous spondylitis: clinical symptoms is similar to ankylosing spondylitis, but x-ray inspection can provide discriminating.During tuberculous spondylitis, vertebra edge blurry is unclear, narrowing of intervertebral space, front Wedging, and without ligament calcification, sometimes have vertebra other tuberculosis abscess shade to exist, sacroiliac joint is one-sided getting involved.5. rheumatoid arthritis: ankylosing spondylitis is not a kind of specific type of rheumatoid arthritis (RA), and both have many differences to provide discriminating.RA is common in women, usually first invades brothers' Minor articulus, and in bilateral symmetric property, sacroiliac joint is not generally got involved, and as invaded spinal column, invades cervical vertebra for many, and without the other ligament calcification of vertebra, have rheumatoid subcutaneous nodule, serum RF is often positive, and HLA-B27 antigen is often negative.6. enteropathic arthropathy: ulcerative colitis, regional enteritis or whipple disease (Whipple is sick) all spondylitis can occur, and enteropathic arthropathy affected joints and x-ray change similar to AS and not easily distinguish, therefore need to find bowel symptoms and sign, as a means of discriminating.The colon mucosa ulcer of ulcerative colitis, edema and bloody diarrhea; The stomachache of regional enteritis, malnutrition and fistulization; The steatorrhea of Whipple disease, sharply to become thin, all contribute to the diagnosis of primary disease.Enteropathic arthropathy patient HLA-B27 positive rate is low, and Crohn patient intestinal irrigating solution IgG increases, and in patients with ankylosing spondylitis intestinal irrigating solution, IgG is normal.7.Reiter syndrome and psoriatic arthritis: two diseases all spondylitis and sacroiliitis can occur, but spondylitis generally occurs more late, lighter, the other tissue calcification of vertebra is few, syndesmophyte is based on non-edge type, and between adjacent two vertebral bodys, forming section bone bridge is different from the bamboo spine of ankylosing spondylitis; Sacroiliitis is generally Unilateral or bilateral asymmetry, and apophyseal joint pathological changes is rare, without universality osteoporosis.In addition, Reiter syndrome has conjunctivitis, urethritis, mucosa and skin lesion; Psoriatic arthritis then has skin psoriasis lesion etc. can supply to differentiate.

The inspection method of ankylosing spondylitis: lab testing: routine blood test and erythrocyte sedimentation rate routine blood test can be roughly normal, and some patients can have positive cell hypochrosis and leukocytosis.Most patient in early days or active stage erythrocyte sedimentation rate speedup, stage erythrocyte sedimentation rate is normal.Erythrocyte sedimentation rate speedup contributes to showing suspicious patient to clinical and x-ray and diagnoses.When kidney generation Amyloidosis, can albuminuria be there is in routine urinalysis.1. blood biochemistry checking: ankylosing spondylitis does not have diagnostic or specific inspection.Routine blood test can have slight leukocyte and platelet to increase, and the patient of 15% can have slight positive cell normochromic anemia.The patient of more than 75% occurs that erythrocyte sedimentation rate speeds, and acute stage or inflammatory reaction severe one also can have c reactive protein to raise.

2. immunologic test: rheumatoid factor positive rate is not high.Serum IgA can have gently-moderate rising, and it is relevant with the activity of the ankylosing spondylitis state of an illness, IgG, IgM can be had to raise with periphery joint involvement person, patients with ankylosing spondylitis can have serum complement C3, C4 to raise, the antibody horizontals such as anti-Peptidoglycan antibody, anti-fruit bat 93000 antibody, anti-klebsiella pneumoniae Reduction By Nitrogenase enzyme antibody increase, anti-histone 3 subunit antibody and patient's iritis closely related.HLA divides the patient HLA-B27 of type checking about 90% positive.3. microbiological examination: the recall rate of patients with ankylosing spondylitis stool klebsiella pneumoniae is higher than normal person.4.HLA-B27 detects: HLA-B27 detects has certain help to the diagnosis of ankylosing spondylitis, but the patient of the overwhelming majority only has and just can make diagnosis by medical history, sign and x-ray inspection.

The complication of ankylosing spondylitis: 1. sacroiliac joint and joint of lumbar vertebra are subject to for a long time simultaneously, the obvious spasm of paravertebral muscles, and lumbar spinal column straightens, limitation of movement, waist normal physiological bending disappears.Joint of thoracic vertebra is also subject to for a long time, and thoracic expansion is limited causes dyspnea.Serious trachelokyphosis or side convex etc., once there is cervical trauma fracture, can paraplegia be caused.Treatment of late ankylosing spondylitis, individuals patients can seriously be disabled.2. when heart change is serious, can concurrent aortic incompetence, cardiac dilatation and conduction abnormalities.Concurrent aortitis, also can merge pericarditis, myocarditis and polyarteritis nodosa.During pulmonary lesion, can there is fibrosis in some patients, and cavity appears in some patient, and have aspergillosis parasitic.Periarticular is scorching or had urinary tract infection history person in the past, if without treatment, can cause glaucoma or blind.Ankylosing spondylitis can cause many neural complications, as spontaneous atlantoaxial dislocation, shows as cervical region severe pain, often emits to temples, occipitalia or socket of the eye rear portion.

Current control AS therapeutic purposes are to control inflammation, and alleviate or relief of symptoms, maintain normal posture and best-of-breed functionality position, prevent deformity.Drug therapy many employings nonsteroidal antiinflammatory drug coordinates sulfasalazine (SSZ), there is anti-inflammatory analgetic, alleviate stiff and muscle spasm effect, but side effect is gastrointestinal reaction, kidney damage, prolongation bleeding time, erythra, hemogram and liver function change etc., and side effect is clearly relevant with service time to dosage.But said medicine all has certain toxicity, be unfavorable for taking for a long time, and conventional have dependency and side effect.

Summary of the invention

Technical problem to be solved by this invention is, a kind of medicine for the treatment of ankylosing spondylitis and preparation method thereof is provided, the present invention has invigorating the liver and kidney, effect of the dehumidifying of Eradicates wind and bone and muscle strengthening, have the effect of dredging collateral normal pulse blood circulation promoting and blood stasis dispelling concurrently, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.

In order to solve the problems of the technologies described above, the invention provides a kind of medicine for the treatment of ankylosing spondylitis and preparation method thereof, wherein, comprise following raw medicinal material: a kind of medicine for the treatment of ankylosing spondylitis, it is characterized in that, comprise following raw medicinal material: Herba Scleriae Terrestris, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Lycii, Cortex Lycii, Herba Arthraxonis Hispidi, Radix Rubiae, Herba Selaginellae Moellendorfii, Pollen Typhae, Ramulus Cinnamomi, Radix Rhapontici, Rhizoma Chuanxiong, Radix berchemiae lineatae, Herba Ajugae Lupulinae, Radix Seu Caulis Mucunae Sempervirentis, Rhizoma Sparganii, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm., Radix seu Cortex Heteropanacis, Herba pratiae begonifoliae, Radix et rhizoma smilacinae japonicae, Radix Dipsaci, Radix Achyranthis Bidentatae and Herba Lycopodii.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Scleriae Terrestris 15 ~ 45 parts, 3 ~ 5 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Lycii 12 ~ 32 parts, Cortex Lycii 10 ~ 20 parts, Herba Arthraxonis Hispidi 15 ~ 35 parts, Radix Rubiae 11 ~ 21 parts, Herba Selaginellae Moellendorfii 10 ~ 42 parts, Pollen Typhae 12 ~ 22 parts, Ramulus Cinnamomi 10 ~ 30 parts, Radix Rhapontici 15 ~ 45 parts, Rhizoma Chuanxiong 13 ~ 33 parts, Radix berchemiae lineatae 15 ~ 25 parts, Herba Ajugae Lupulinae 12 ~ 32 parts, Radix Seu Caulis Mucunae Sempervirentis 11 ~ 21 parts, Rhizoma Sparganii 16 ~ 38 parts, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm. 15 ~ 46 parts, Radix seu Cortex Heteropanacis 2 ~ 4 parts, Herba pratiae begonifoliae 13 ~ 36 parts, Radix et rhizoma smilacinae japonicae 15 ~ 25 parts, Radix Dipsaci 12 ~ 32 parts, Radix Achyranthis Bidentatae 10 ~ 40 parts and Herba Lycopodii 14 ~ 28 parts.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Scleriae Terrestris 40 parts, 3 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Lycii 24 parts, Cortex Lycii 15 parts, Herba Arthraxonis Hispidi 32 parts, Radix Rubiae 15 parts, Herba Selaginellae Moellendorfii 36 parts, Pollen Typhae 14 parts, Ramulus Cinnamomi 25 parts, Radix Rhapontici 42 parts, Rhizoma Chuanxiong 23 parts, Radix berchemiae lineatae 17 parts, Herba Ajugae Lupulinae 30 parts, Radix Seu Caulis Mucunae Sempervirentis 14 parts, Rhizoma Sparganii 25 parts, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm. 42 parts, Radix seu Cortex Heteropanacis 3 parts, Herba pratiae begonifoliae 34 parts, Radix et rhizoma smilacinae japonicae 22 parts, Radix Dipsaci 28 parts, Radix Achyranthis Bidentatae 40 parts and Herba Lycopodii 20 parts.

In described medicine, each raw medicinal material also comprises: Rhizoma Iridis Tectori, Fructus Leonuri, Herba Stachytarphetae Jamaicensis, Radix Patriniae heterophyllae and Rhizoma Homalomenae.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Scleriae Terrestris 15 ~ 45 parts, 3 ~ 5 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Lycii 12 ~ 32 parts, Cortex Lycii 10 ~ 20 parts, Herba Arthraxonis Hispidi 15 ~ 35 parts, Radix Rubiae 11 ~ 21 parts, Herba Selaginellae Moellendorfii 10 ~ 42 parts, Pollen Typhae 12 ~ 22 parts, Ramulus Cinnamomi 10 ~ 30 parts, Radix Rhapontici 15 ~ 45 parts, Rhizoma Chuanxiong 13 ~ 33 parts, Radix berchemiae lineatae 15 ~ 25 parts, Herba Ajugae Lupulinae 12 ~ 32 parts, Radix Seu Caulis Mucunae Sempervirentis 11 ~ 21 parts, Rhizoma Sparganii 16 ~ 38 parts, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm. 15 ~ 46 parts, Radix seu Cortex Heteropanacis 2 ~ 4 parts, Herba pratiae begonifoliae 13 ~ 36 parts, Radix et rhizoma smilacinae japonicae 15 ~ 25 parts, Radix Dipsaci 12 ~ 32 parts, Radix Achyranthis Bidentatae 10 ~ 40 parts, Herba Lycopodii 14 ~ 28 parts, Rhizoma Iridis Tectori 3 ~ 4 parts, Fructus Leonuri 15 ~ 35 parts, Herba Stachytarphetae Jamaicensis 11 ~ 21 parts, Radix Patriniae heterophyllae 16 ~ 42 parts and Rhizoma Homalomenae 12 ~ 22 parts.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Scleriae Terrestris 40 parts, 3 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Lycii 24 parts, Cortex Lycii 15 parts, Herba Arthraxonis Hispidi 32 parts, Radix Rubiae 15 parts, Herba Selaginellae Moellendorfii 36 parts, Pollen Typhae 14 parts, Ramulus Cinnamomi 25 parts, Radix Rhapontici 42 parts, Rhizoma Chuanxiong 23 parts, Radix berchemiae lineatae 17 parts, Herba Ajugae Lupulinae 30 parts, Radix Seu Caulis Mucunae Sempervirentis 14 parts, Rhizoma Sparganii 25 parts, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm. 42 parts, Radix seu Cortex Heteropanacis 3 parts, Herba pratiae begonifoliae 34 parts, Radix et rhizoma smilacinae japonicae 22 parts, Radix Dipsaci 28 parts, Radix Achyranthis Bidentatae 40 parts, Herba Lycopodii 20 parts, Rhizoma Iridis Tectori 3 parts, Fructus Leonuri 26 parts, Herba Stachytarphetae Jamaicensis 14 parts, Radix Patriniae heterophyllae 32 parts and Rhizoma Homalomenae 18 parts.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Scleriae Terrestris 35 parts, 4 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Lycii 20 parts, Cortex Lycii 18 parts, Herba Arthraxonis Hispidi 25 parts, Radix Rubiae 20 parts, Herba Selaginellae Moellendorfii 32 parts, Pollen Typhae 16 parts, Ramulus Cinnamomi 23 parts, Radix Rhapontici 34 parts, Rhizoma Chuanxiong 20 parts, Radix berchemiae lineatae 25 parts, Herba Ajugae Lupulinae 16 parts, Radix Seu Caulis Mucunae Sempervirentis 15 parts, Rhizoma Sparganii 28 parts, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm. 36 parts, Radix seu Cortex Heteropanacis 3 parts, Herba pratiae begonifoliae 30 parts, Radix et rhizoma smilacinae japonicae 18 parts, Radix Dipsaci 24 parts, Radix Achyranthis Bidentatae 30 parts, Herba Lycopodii 24 parts, Rhizoma Iridis Tectori 3 parts, Fructus Leonuri 32 parts, Herba Stachytarphetae Jamaicensis 16 parts, Radix Patriniae heterophyllae 40 parts and Rhizoma Homalomenae 22 parts.

When the dosage form of described medicine is unguentum, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;

Second step, stearic acid heating dissolved, remaining on temperature is 70 DEG C ~ 80 DEG C, obtains stearic acid liquid; In addition, potassium hydroxide, glycerol, ethyl hydroxybenzoate and distilled water are mixed in proportion, heating, maintains the temperature at 70 DEG C ~ 80 DEG C, obtains distilled water mixed liquor; Stearic acid liquid is slowly joined in distilled water mixed liquor, stirs cooling simultaneously, obtain substrate;

3rd step, joins the Chinese medicinal powder that the first step obtains in the substrate of second step acquisition and is also constantly ground to evenly, obtain unguentum.

When the dosage form of described medicine is granule, its preparation method comprises the following steps:

The first step, each for described medicine raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, is ground into powder subsequently, makes dried cream powder;

Second step, adds the dextrin of cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times, makes granule in the dried cream powder obtained, and in 40 ~ 50 DEG C of dryings, obtains granule.

The invention has the beneficial effects as follows: the present invention has invigorating the liver and kidney, the dehumidifying of Eradicates wind and effect of bone and muscle strengthening, have the effect of dredging collateral normal pulse blood circulation promoting and blood stasis dispelling concurrently, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.

Detailed description of the invention

The present invention is with invigorating the liver and kidney, the dehumidifying of Eradicates wind and bone and muscle strengthening are primary treatment principle, treatment postmen opausal, wherein, following raw medicinal material is comprised: Herba Scleriae Terrestris, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Lycii, Cortex Lycii, Herba Arthraxonis Hispidi, Radix Rubiae, Herba Selaginellae Moellendorfii, Pollen Typhae, Ramulus Cinnamomi, Radix Rhapontici, Rhizoma Chuanxiong, Radix berchemiae lineatae, Herba Ajugae Lupulinae, Radix Seu Caulis Mucunae Sempervirentis, Herba Stachytarphetae Jamaicensis, Rhizoma Sparganii, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm., Radix seu Cortex Heteropanacis, Herba pratiae begonifoliae, Radix Patriniae heterophyllae, Rhizoma Iridis Tectori, Radix et rhizoma smilacinae japonicae, Radix Dipsaci, Fructus Leonuri, Radix Achyranthis Bidentatae, Rhizoma Homalomenae and Herba Lycopodii.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Cortex cinnamomi japonici (Ramulus Cinnamomi): source: Collective Notes to the Canon of Materia medica.Nature and flavor: pungent, temperature.1. " Kaibao Bencao ": " acrid in the mouth, temperature, nontoxic." 2. " Traditional Chinese Medicine in Sichuan will ": " extremely hot in nature, acrid-sweet flavor, slightly poisonous." return through: " Traditional Chinese Medicine in Sichuan will ": " enters the heart, liver,spleen,kidney four warp." cure mainly: warming the spleen and stomach, dispersing wind and cold, promoting blood circulation.Control the cold fullness in the chest of abdomen, vomit dysphagic, rheumatic arthralgia, fall damage the stasis of blood stagnant, dysentery hemorrhoidal hamorrhage.1. supplement to the Herbal: " control in abdomen all cold, vim and vigour distending pain." 2. " Haiyao Bencao, Oversea Materia Medica ": " mends warm waist foot, and stagnant blood after bankruptcy, controls dysentery hemorrhoidal hamorrhage, and power is same with Cortex Cinnamomi." 3. " Traditional Chinese Medicine in Sichuan will ": " liver and kidney tonifying, qualcomm meridian, dispersing wind and cold, except arthralgia chiefly caused by damp pathogen, warm waist knee joint, anti-nausea.Control bones and muscles pain, diarrhea due to cold pathogen is suffered from abdominal pain, and cholera is vomitted, dysphagic fullness in the chest, bladder colic of cold type, and waist knee joint is existing cold, and rheumatic arthralgia and falling damages the diseases such as the stasis of blood is stagnant."

Fructus Lycii: nature and flavor: sweet is flat.Gui Jing: return liver, kidney channel.Cure mainly: nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.

Cortex Lycii: source: " herbal classic ".Nature and flavor: sweet, cold.1. " herbal classic ": " bitter in the mouth, cold." 2. " not Lu ": " Great Cold, nontoxic." 3. " detailed outline ": " slightly sweet flavor, cold." return through: enter lung, liver, kidney channel.1. Materia Medica of Decoction: " foot is few cloudy, meridian of Hand-SHAO YANG." 2. " Thunder God concocts property of medicine solution ": " enters lung, kidney two warp." 3. " book on Chinese herbal medicine converges and says ": " enters few cloudy, the meridian of Foot-JUE YIN of foot." cure mainly: heat clearing away, removing heat from blood.Control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil.1. " herbal classic ": " pathogen in main five, hankers quenching one's thirst, general arthralgia." 2. " not Lu ": " main air wets, lower breast side of body gas, and exopathogenic heat is had a headache, and mends internal injury great Lao and to hiss suction, hard muscle, reinforcing YIN-essence, sharp intestine and small intestine, resistance to cold and summer-heat." 3. " property of medicine opinion ": " smooth file, face is mixed and is well-donely gulped down it, cures mainly kidney family tradition." 4. " Treatise on Dietetic Therapy ": " heat of boning is quenched one's thirst."

Herba Arthraxonis Hispidi: nature and flavor: bitter is flat.Cure mainly: heat clearing away, sending down the abnormal ascending QI, relieving cough and asthma, removing toxic substances, Eradicates rheumatism.Cure mainly hepatitis, chronic cough is panted, pharyngolaryngitis, stomatitis, rhinitis, lymphadenitis, mastitis.Scabies is controlled in external, skin pruritus, carbuncle furuncle.

Radix Rubiae: source: " herbal classic " original work rubia.Nature and flavor: bitter, cold.1. " herbal classic ": " bitter in the mouth, cold." 2. " not Lu ": " be salty, flat, nontoxic." return through: enter the heart.Liver Channel.1. " detailed outline ": " hands, sufficient cloudy blood system of fainting." 2. " Bencao Jingshu ": " enters sufficient the moon of fainting, and hands, foot are few cloudy." 3. " book on Chinese herbal medicine is newly organized ": " enters spleen, stomach two warp." cure mainly: promoting the circulation of blood is stopped blooding, dredge the meridian passage, eliminating phlegm and stopping cough.Control haematemesis, epistaxis, hematuria, have blood in stool, metrorrhagia, amenorrhea, rheumatic arthralgia, traumatic injury, the stasis of blood is stagnant to swell and ache, jaundice, chronic tracheitis.

Herba Selaginellae Moellendorfii: source: " vegetation is side just ".Nature and flavor: Gan Xin are flat.1. " vegetation is side just ": " pungent, flat." 2. " Traditional Chinese Medicine in Sichuan will ": " is lightly seasoned micro-pungent, and property is put down, nontoxic." 3. " Jiangxi medical herbs ": " sweet in the mouth, property is put down." cure mainly: hemostasis, heat clearing away, dampness removing.Control haematemesis, hemorrhoidal bleeding, have blood in stool, metrorrhagia, wound hemorrhage, jaundice, gonorrhea, infantile convulsion." vegetation is side just ": " hemostasis, qualcomm meridian, relieving palpitation relieving restlessness, settling five organs.Control the inferior blood, collapse pouring, cutter axe bleeding due to trauma."

Pollen Typhae: source: " herbal classic ".Nature and flavor: Gan Xin are cool.Gui Jing: enter liver, heart channel.1. " detailed outline ": " hands, sufficient cloudy blood system of fainting." 2. " Bencao Jingshu ": " few the moon of starting with, the sun, lunar, bright, the moon of fainting of foot sun." 3. " medicineization justice ": " enters spleen channel." cure mainly: cooling blood for hemostasis, activating blood circulation and dissipating blood stasis." property of medicine opinion ": " qualcomm meridian, only woman's metrorrhagia incessantly, main dysentery blood, and only epistaxis, controls hematuria, dredging water passages."

Ramulus Cinnamomi: source: Tang Materia Medica.Gui Jing: enter bladder, the heart, lung meridian.Cure mainly: diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation.Control exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea lump in the abdomen.Essentials of Matea Medica: " warming the meridian and promoting blood circulation, diaphoresis expelling pathogenic factors from muscles." 6. " book on Chinese herbal medicine is new again ": " warming middle-JIAO promoting the circulation of blood, the dry stomach of spleen invigorating, detumescence dampness removing.Control brothers feel cold do fiber crops, muscle takes out pain, and diseases caused by exogenous pathogenic factor are cold and cool waits disease."

Radix Rhapontici: nature and flavor: bitter, cold.Gui Jing: return stomach warp.Cure mainly: heat-clearing and toxic substances removing, eliminating carbuncle, stimulating milk secretion, relaxing muscles and tendons is promoted blood circulation.Swell and ache for acute mastitis, carbuncle carbuncle on the back, scrofula sore, galactostasis, arthralgia chiefly caused by damp pathogen contracture.

Rhizoma Chuanxiong: nature and flavor: pungent, temperature.Gui Jing: return liver, gallbladder, pericardium channel.Cure mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.

Radix berchemiae lineatae: source: " south of the Five Ridges gather medicinal herbs record ".Nature and flavor: bitter are flat.1. " south of the Five Ridges gather medicinal herbs record ": " bitter in the mouth, warm in nature." 2. " Fujian traditional herbal medicine ": " micro-hardship, flat, nontoxic." 3. Guangzhou army " conventional Chinese herbal medicine handbook ": " is sweet light, flat." cure mainly: Removing Blood Stasis, wind-damp dispelling, detumescence poison.Control pulmonary tuberculosis chronic cough, noise made in coughing or vomiting blood, spit blood, traumatic injury, rheumatalgia, carbuncle, urticaria." south of the Five Ridges herbal ": " energy blood stasis dispelling, controls spitting of blood, hemoptysis."

Radix Seu Caulis Mucunae Sempervirentis: nature and flavor: sweet, temperature.Cure mainly: blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness, dredge the meridian passage.For traumatic injury, rheumatalgia, numbness, stimulate the menstrual flow, amenorrhea.

Herba Stachytarphetae Jamaicensis: source: " Guangxi conventional medical herbs among the people ".Nature and flavor: sweetness and bitterness, cold.1. " Guangxi conventional medical herbs among the people ": " sweet, cold, nontoxic." 2. Guangzhou army " conventional Chinese herbal medicine handbook ": " micro-hardship, cold." cure mainly: dampness removing blood stasis dispelling, heat-clearing and toxic substances removing.Control gonorrhea, nebulousurine, rheumatic arthralgia, conjunctivitis, laryngitis, traumatic injury congestive edema, carbuncle furuncle.

Rhizoma Sparganii: source: supplement to the Herbal.Nature and flavor: toil are flat.1. supplement to the Herbal: " sweet flat, temperature." 2. " Japan hanako materia medica ": " sweet-puckery flavor is cool." 3. " Kaibao Bencao ": " bitter in the mouth is flat, nontoxic." 4. " Amplification on Materia Medica addendum ": " works hard." return through: enter liver.Spleen channel.1. " Thunder God process of preparing Chinese medicine property of medicine solution " > Thunder God concocts property of medicine solution ": " enter lung, spleen two warp." 2. " Bencao Jingshu ": " enters foot and faints cloudy, lunar." cure mainly: removing blood stasis, circulation of qi promoting, removing food stagnancy, pain relieving.Control lump in the abdomen, coagulation of QI-blood, trusted subordinate's pain, the lower swollen pain of the side of body, amenorrhea, postnatal blood stasis is suffered from abdominal pain, traumatic injury.Skin ulcer swells hard.

Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm.: source: " Yunnan Chinese herbal medicine ".Nature and flavor: sweet are flat.Cure mainly: relaxing muscles and tendons and activating QI and blood in the collateral, synthetism.

Radix seu Cortex Heteropanacis: nature and flavor: pungent, temperature.Poisonous.Cure mainly: expelling wind and activating blood circulation, hemostasis and pain-relieving.For fracture, traumatic injury, rheumatalgia; Traumatic hemorrhage is controlled in external.

Herba pratiae begonifoliae: nature and flavor: pungent, bitter is flat.Cure mainly: expelling wind and removing dampness, promoting blood circulation to remove blood stasis.For rheumatalgia, menoxenia, leucorrhea, seminal emission; Traumatic injury is controlled in external, wound hemorrhage.

Radix Patriniae heterophyllae: source: " detailed outline ".Nature and flavor: " Guangxi Chinese medicinal herbal ": " acrid in the mouth, warm in nature." return through: " Guangxi Chinese medicinal herbal ": " enters the heart, liver two warp." cure mainly: control pyrexial malaria, women's metrorrhagia, leucorrhea with red and white discharge, traumatic injury." Guangxi Chinese medicinal herbal ": " blood stasis dispelling, detumescence.Control traumatic injury."

Rhizoma Iridis Tectori: nature and flavor: bitter, pungent is flat.Slightly poisonous.Cure mainly: blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness, removing toxic substances, removing food stagnancy.For traumatic injury, rheumatalgia, laryngopharynx swelling and pain, dyspeptic abdominal distention, malaria; Carbuncle furuncle and phyma poison is controlled in external, traumatic hemorrhage.

Radix et rhizoma smilacinae japonicae: source: " a thousand pieces of gold dietetic therapy ".Nature and flavor: sweetness and bitterness, temperature.1. " Kaibao Bencao ": " sweet, temperature, nontoxic." 2. " Shaanxi Chinese herbal medicine ": " Gan Weixin, temperature." cure mainly: QI invigorating kidney tonifying, expelling wind and removing dampness, promoting blood flow to regulate menstruation.Control consumptive disease wound, sexual impotence, inclined, aching all over the head, rheumatalgia, traumatic injury, acute mastitis, menoxenia.

Radix Dipsaci: nature and flavor: bitter, pungent, tepor.Gui Jing: return liver, kidney channel.Cure mainly: invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia.For soreness of the waist and knees, rheumatic arthralgia, metrorrhagia, vaginal bleeding during pregnancy, injury from falling down.Prepared RADIX DIPSACI with yellow rice wine is used for rheumatic arthralgia, injury from falling down.Prepared RADIX DIPSACI with salt solution is used for soreness of the waist and knees.

Fructus Leonuri: nature and flavor: pungent, bitter, is slightly cold.Gui Jing: GUIXIN bag, Liver Channel.Cure mainly: promoting blood flow to regulate menstruation, liver heat removing and eyesight improving.For menoxenia, amenorrhea, dysmenorrhea, cataract, dizzy distending pain.

Radix Achyranthis Bidentatae: source: " herbal classic ".Nature and flavor: sweet, bitter, sour are flat.Gui Jing: enter liver, kidney channel.Cure mainly: life dissipating blood stasis blood, subduing inflammation.Control gonorrhea, hematuria, amenorrhea, lump in the abdomen, difficult labour, retention of placenta, postnatal blood stasis is suffered from abdominal pain, sore throat, carbuncle, traumatic injury.Ripe invigorating the liver and kidney, bone and muscle strengthening.Control waist kneecap pain, spasm of the limbs, flaccidity syndrome and arthralgia syndrome.

Rhizoma Homalomenae: nature and flavor: bitter, pungent, temperature.Gui Jing: return liver, kidney channel.Cure mainly: wind-damp dispelling, muscle reinforcing and bone strengthening, promoting blood circulation and stopping pain.For anemofrigid-damp arthralgia, chills and pain of the waist and kness, lower limb contracture is numb.

Herba Scleriae Terrestris: nature and flavor: micro-hardship is flat.Cure mainly: except rheumatism, the meridian dredging.Cure mainly bones and muscles pain due to rheumatism, paralysis, traumatic injury.

Herba Ajugae Lupulinae: source: " Qinghai-Tibet medicine illustrated handbook ".Nature and flavor: " Chinese herbal medicine is commonly used in Tibet ": " bitter, cold." return through: " plateau Chinese herbal treatment handbook ": " enters Liver and kidney two warp." cure mainly: heat-clearing and toxic substances removing, promoting blood circulation and detumescence.Cure cold wind heat, laryngopharynx swelling and pain, cough, spits blood, hypertension, facial paralysis, traumatic injury stasis of blood pain.1. " Chinese herbal medicine is commonly used in Tibet ": " heat-clearing and toxic substances removing, relieving stranguria by diuresis, removing heat from blood blood pressure lowering.Control affection due to external wind and heat, hypertension, pharyngolaryngitis, bronchitis, lithangiuria, sore and toxic." 2. " Qinghai-Tibet medicine illustrated handbook ": " detoxifies.Control influenza, toxic liver injury and liver stomach complication." 3. " plateau Chinese herbal treatment handbook ": " is antipyretic antibacterial, promoting blood circulation and detumescence.Control fall damage the stasis of blood coagulate, facial paralysis mouth is askew, epersalgia cough, spit blood, pain due to disorder of QI sterilize, anthrax."

Herba Lycopodii: nature and flavor: micro-hardship, pungent, temperature.Gui Jing: return liver,spleen,kidney warp.Cure mainly: expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, joint stuffiness.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Scleriae Terrestris 15 ~ 45 parts, 3 ~ 5 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Lycii 12 ~ 32 parts, Cortex Lycii 10 ~ 20 parts, Herba Arthraxonis Hispidi 15 ~ 35 parts, Radix Rubiae 11 ~ 21 parts, Herba Selaginellae Moellendorfii 10 ~ 42 parts, Pollen Typhae 12 ~ 22 parts, Ramulus Cinnamomi 10 ~ 30 parts, Radix Rhapontici 15 ~ 45 parts, Rhizoma Chuanxiong 13 ~ 33 parts, Radix berchemiae lineatae 15 ~ 25 parts, Herba Ajugae Lupulinae 12 ~ 32 parts, Radix Seu Caulis Mucunae Sempervirentis 11 ~ 21 parts, Rhizoma Sparganii 16 ~ 38 parts, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm. 15 ~ 46 parts, Radix seu Cortex Heteropanacis 2 ~ 4 parts, Herba pratiae begonifoliae 13 ~ 36 parts, Radix et rhizoma smilacinae japonicae 15 ~ 25 parts, Radix Dipsaci 12 ~ 32 parts, Radix Achyranthis Bidentatae 10 ~ 40 parts and Herba Lycopodii 14 ~ 28 parts.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Scleriae Terrestris 40 parts, 3 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Lycii 24 parts, Cortex Lycii 15 parts, Herba Arthraxonis Hispidi 32 parts, Radix Rubiae 15 parts, Herba Selaginellae Moellendorfii 36 parts, Pollen Typhae 14 parts, Ramulus Cinnamomi 25 parts, Radix Rhapontici 42 parts, Rhizoma Chuanxiong 23 parts, Radix berchemiae lineatae 17 parts, Herba Ajugae Lupulinae 30 parts, Radix Seu Caulis Mucunae Sempervirentis 14 parts, Rhizoma Sparganii 25 parts, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm. 42 parts, Radix seu Cortex Heteropanacis 3 parts, Herba pratiae begonifoliae 34 parts, Radix et rhizoma smilacinae japonicae 22 parts, Radix Dipsaci 28 parts, Radix Achyranthis Bidentatae 40 parts and Herba Lycopodii 20 parts.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Scleriae Terrestris 15 ~ 45 parts, 3 ~ 5 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Lycii 12 ~ 32 parts, Cortex Lycii 10 ~ 20 parts, Herba Arthraxonis Hispidi 15 ~ 35 parts, Radix Rubiae 11 ~ 21 parts, Herba Selaginellae Moellendorfii 10 ~ 42 parts, Pollen Typhae 12 ~ 22 parts, Ramulus Cinnamomi 10 ~ 30 parts, Radix Rhapontici 15 ~ 45 parts, Rhizoma Chuanxiong 13 ~ 33 parts, Radix berchemiae lineatae 15 ~ 25 parts, Herba Ajugae Lupulinae 12 ~ 32 parts, Radix Seu Caulis Mucunae Sempervirentis 11 ~ 21 parts, Rhizoma Sparganii 16 ~ 38 parts, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm. 15 ~ 46 parts, Radix seu Cortex Heteropanacis 2 ~ 4 parts, Herba pratiae begonifoliae 13 ~ 36 parts, Radix et rhizoma smilacinae japonicae 15 ~ 25 parts, Radix Dipsaci 12 ~ 32 parts, Radix Achyranthis Bidentatae 10 ~ 40 parts, Herba Lycopodii 14 ~ 28 parts, Rhizoma Iridis Tectori 3 ~ 4 parts, Fructus Leonuri 15 ~ 35 parts, Herba Stachytarphetae Jamaicensis 11 ~ 21 parts, Radix Patriniae heterophyllae 16 ~ 42 parts and Rhizoma Homalomenae 12 ~ 22 parts.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Scleriae Terrestris 40 parts, 3 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Lycii 24 parts, Cortex Lycii 15 parts, Herba Arthraxonis Hispidi 32 parts, Radix Rubiae 15 parts, Herba Selaginellae Moellendorfii 36 parts, Pollen Typhae 14 parts, Ramulus Cinnamomi 25 parts, Radix Rhapontici 42 parts, Rhizoma Chuanxiong 23 parts, Radix berchemiae lineatae 17 parts, Herba Ajugae Lupulinae 30 parts, Radix Seu Caulis Mucunae Sempervirentis 14 parts, Rhizoma Sparganii 25 parts, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm. 42 parts, Radix seu Cortex Heteropanacis 3 parts, Herba pratiae begonifoliae 34 parts, Radix et rhizoma smilacinae japonicae 22 parts, Radix Dipsaci 28 parts, Radix Achyranthis Bidentatae 40 parts, Herba Lycopodii 20 parts, Rhizoma Iridis Tectori 3 parts, Fructus Leonuri 26 parts, Herba Stachytarphetae Jamaicensis 14 parts, Radix Patriniae heterophyllae 32 parts and Rhizoma Homalomenae 18 parts.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Scleriae Terrestris 35 parts, 4 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Lycii 20 parts, Cortex Lycii 18 parts, Herba Arthraxonis Hispidi 25 parts, Radix Rubiae 20 parts, Herba Selaginellae Moellendorfii 32 parts, Pollen Typhae 16 parts, Ramulus Cinnamomi 23 parts, Radix Rhapontici 34 parts, Rhizoma Chuanxiong 20 parts, Radix berchemiae lineatae 25 parts, Herba Ajugae Lupulinae 16 parts, Radix Seu Caulis Mucunae Sempervirentis 15 parts, Rhizoma Sparganii 28 parts, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm. 36 parts, Radix seu Cortex Heteropanacis 3 parts, Herba pratiae begonifoliae 30 parts, Radix et rhizoma smilacinae japonicae 18 parts, Radix Dipsaci 24 parts, Radix Achyranthis Bidentatae 30 parts, Herba Lycopodii 24 parts, Rhizoma Iridis Tectori 3 parts, Fructus Leonuri 32 parts, Herba Stachytarphetae Jamaicensis 16 parts, Radix Patriniae heterophyllae 40 parts and Rhizoma Homalomenae 22 parts.

When the dosage form of described medicine is unguentum, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;

Second step, stearic acid heating dissolved, remaining on temperature is 70 DEG C ~ 80 DEG C, obtains stearic acid liquid; In addition, potassium hydroxide, glycerol, ethyl hydroxybenzoate and distilled water are mixed in proportion, heating, maintains the temperature at 70 DEG C ~ 80 DEG C, obtains distilled water mixed liquor; Stearic acid liquid is slowly joined in distilled water mixed liquor, stirs cooling simultaneously, obtain substrate;

3rd step, joins the Chinese medicinal powder that the first step obtains in the substrate of second step acquisition and is also constantly ground to evenly, obtain unguentum.

When the dosage form of described medicine is granule, its preparation method comprises the following steps:

The first step, each for described medicine raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, is ground into powder subsequently, makes dried cream powder;

Second step, adds the dextrin of cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times, makes granule in the dried cream powder obtained, and in 40 ~ 50 DEG C of dryings, obtains granule.

Embodiment 1 unguentum 1

The manufacturing process of unguentum of the present invention is: get Herba Scleriae Terrestris 400g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 30g, Fructus Lycii 240g, Cortex Lycii 150g, Herba Arthraxonis Hispidi 320g, Radix Rubiae 150g, Herba Selaginellae Moellendorfii 360g, Pollen Typhae 140g, Ramulus Cinnamomi 250g, Radix Rhapontici 420g, Rhizoma Chuanxiong 230g, Radix berchemiae lineatae 170g, Herba Ajugae Lupulinae 300g, Radix Seu Caulis Mucunae Sempervirentis 140g, Rhizoma Sparganii 250g, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm. 420g, Radix seu Cortex Heteropanacis 30g, Herba pratiae begonifoliae 340g, Radix et rhizoma smilacinae japonicae 220g, Radix Dipsaci 280g, Radix Achyranthis Bidentatae 400g and Herba Lycopodii 200g;

The first step, is mixed in proportion each for described medicine raw medicinal material, is ground into 45 object powder, and adding relative to the determining alcohol of mixture quality 2.5 times is the ethanol of 90%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1.5 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 180 object powder;

Second step, stearic acid heating dissolved, remaining on temperature is 75 DEG C, obtains stearic acid liquid; In addition, potassium hydroxide, glycerol, ethyl hydroxybenzoate and distilled water are mixed in proportion, heating, maintains the temperature at 80 DEG C, obtains distilled water mixed liquor; Stearic acid liquid is slowly joined in distilled water mixed liquor, stirs cooling simultaneously, obtain substrate;

3rd step, joins the drug powder that the first step obtains in the substrate of second step acquisition and is also constantly ground to evenly, obtain unguentum.

Embodiment 2 unguentum 2

The manufacturing process of unguentum of the present invention is: get Herba Scleriae Terrestris 400g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 30g, Fructus Lycii 240g, Cortex Lycii 150g, Herba Arthraxonis Hispidi 320g, Radix Rubiae 150g, Herba Selaginellae Moellendorfii 360g, Pollen Typhae 140g, Ramulus Cinnamomi 250g, Radix Rhapontici 420g, Rhizoma Chuanxiong 230g, Radix berchemiae lineatae 170g, Herba Ajugae Lupulinae 300g, Radix Seu Caulis Mucunae Sempervirentis 140g, Rhizoma Sparganii 250g, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm. 420g, Radix seu Cortex Heteropanacis 30g, Herba pratiae begonifoliae 340g, Radix et rhizoma smilacinae japonicae 220g, Radix Dipsaci 280g, Radix Achyranthis Bidentatae 400g, Herba Lycopodii 200g, Rhizoma Iridis Tectori 30g, Fructus Leonuri 260g, Herba Stachytarphetae Jamaicensis 140g, Radix Patriniae heterophyllae 320g and Rhizoma Homalomenae 180g,

The first step, is mixed in proportion each for described medicine raw medicinal material, is ground into 50 object powder, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 95%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 1.5 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 150 object powder;

Second step, stearic acid heating dissolved, remaining on temperature is 70 DEG C, obtains stearic acid liquid; In addition, potassium hydroxide, glycerol, ethyl hydroxybenzoate and distilled water are mixed in proportion, heating, maintains the temperature at 75 DEG C, obtains distilled water mixed liquor; Stearic acid liquid is slowly joined in distilled water mixed liquor, stirs cooling simultaneously, obtain substrate;

3rd step, joins the Chinese medicinal powder that the first step obtains in the substrate of second step acquisition and is also constantly ground to evenly, obtain unguentum.

Embodiment 3 granule

The manufacturing process of granule of the present invention is: get Herba Scleriae Terrestris 350g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 40g, Fructus Lycii 200g, Cortex Lycii 180g, Herba Arthraxonis Hispidi 250g, Radix Rubiae 200g, Herba Selaginellae Moellendorfii 320g, Pollen Typhae 160g, Ramulus Cinnamomi 230g, Radix Rhapontici 340g, Rhizoma Chuanxiong 200g, Radix berchemiae lineatae 250g, Herba Ajugae Lupulinae 160g, Radix Seu Caulis Mucunae Sempervirentis 150g, Rhizoma Sparganii 280g, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm. 360g, Radix seu Cortex Heteropanacis 30g, Herba pratiae begonifoliae 300g, Radix et rhizoma smilacinae japonicae 180g, Radix Dipsaci 240g, Radix Achyranthis Bidentatae 300g, Herba Lycopodii 240g, Rhizoma Iridis Tectori 30g, Fructus Leonuri 320g, Herba Stachytarphetae Jamaicensis 160g, Radix Patriniae heterophyllae 400g and Rhizoma Homalomenae 220g,

The first step, mixed in described ratio by each for described medicine raw medicinal material, adding relative to the determining alcohol of 6 times, mixture is the ethanol of 90%, is heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 1.5ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.07Mpa, relative density is the mastic of 1.07, spraying dry, the inlet temperature 170 DEG C of spray dryer, leaving air temp 85 DEG C, is ground into powder subsequently, makes dried cream powder;

Second step, adds the dextrin of cane sugar powder relative to dried cream powder quality 0.3 times and 0.15 times, makes granule in the dried cream powder obtained, and in 45 DEG C of dryings, obtains granule.

Acute dermal toxicity is tested: these product are according to Ministry of Public Health " cosmetics health specification " (2002) Part II " acute dermal toxicity test " test method(s) of once limiting the quantity, SD rat 20, male and female half and half, body weight 90g ~ 180g, the unguentum embodiment of the present invention 1 obtained percutaneous smears 5000mg/kg body weight dose, observes 15 days, does not find obvious poisoning symptom, without dead, animal gross anatomy no abnormality seen, judges that these product are to the nontoxic level in the true border of rat acute percutaneous toxicity.

Acute skin irritation test: these product are according to 6.3 joints in Ministry of Public Health " cosmetics health specification " (2002) Part II " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg ~ 3kg, the unguentum embodiment of the present invention 2 obtained once is got 0.5g and directly to be spread upon on the left of animal on skin (opposite side in contrast), adopt blocking test, 4 hours application time, tested material is remained with warm water washing after off-test, 1h after removing tested material, 24h, 48h and 72h observes the dermoreaction of the tested district of animal and check plot respectively, top average is " 0 ", judge that these product are to animal skin nonirritant.

Acute toxicity test: application NIH mice 40, S recovery from illness F level, male and female half and half, body weight 18 ~ 25g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Granule prepared by embodiments of the invention 3 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Clinical drug dosage of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage medicine of the present invention is 745 times of quantity.Therefore Acute toxicity of the present invention is low, clinical drug safety.

Clinical data:

Case selection: the 308 routine patients with ankylosing spondylitis selected in July, 2013 to 2014 year outpatient service in July or be in hospital, age is between 17-54 year, mean age is 43.35 ± 9.02 years old, the course of disease, between 0.6-8, gets rid of conscience spleen lungs functional defect or can not the sufferer of the person of cooperation with psychosis etc.Compare in sex, age, the state of an illness, Staging of course of disease before above-mentioned all patients treatment, no significant difference (P>0.05), has comparability; Embodiment group 1, embodiment group 2, embodiment group 3 and matched group are divided at random to 308 routine patients, each experimental group 77 people.

Diagnostic criteria: the early diagnosis standard that the clinical and epidemiological study whole nation cooperative groups first seminar of the AS adopting hold in University Of Shantou for 1997 is worked out: i.e. x-ray bilateral sacroiliitis >=II grade or one-sided >=III grade, and have following clinical manifestation more than one or one person: (1) lumbosacral region, buttocks or hip are uncomfortable or ache.(2) hypnalgia or morning are stiff.(3) movable rear alleviation.(4) the few arthritis of asymmetric periphery arthritis, especially lower limb.(5) heel or other tendon attachment points pain.(6) iridocyclitis medical history.

Therapeutic Method:

In medication therapy groups:

Embodiment group 1: use unguentum prepared by the embodiment of the present invention 1, every day 3 times, each 6g 30 days is a course for the treatment of;

Embodiment group 2: use unguentum prepared by the embodiment of the present invention 2, every day 3 times, each 6g 30 days is a course for the treatment of;

Embodiment group 3: use granule prepared by the embodiment of the present invention 3, every day 3 times, once a bag, every bag of 6g every 30 days is 1 course for the treatment of;

Matched group: take meloxicam tablet, every day 3 times, one time 1, within every 30 days, be a course for the treatment of.

Curative effect determinate standard: with reference to the curative effect determinate standard in 2002 " new Chinese medicine guideline of clinical investigations " and in conjunction with document.1. effective: clinical symptoms, sign all disappear or cardinal symptom disappears, and function of joint is recovered substantially, normal work or physical labor can be participated in; 2. effective: cardinal symptom is eliminated substantially, major joint function is substantially recovered or is had made marked progress, and can't take care of oneself to transfer to can take care of oneself, or lose the job and work capacity transfer to work and ability to work recover to some extent; 3. invalid: with treatment before compare, each side all without improve, even increase the weight of.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt Drug therapy ankylosing spondylitis of the present invention, relative to conventional medicament on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt Drug therapy ankylosing spondylitis of the present invention, relative to conventional medicament, treatment the course for the treatment of on significantly shorten.

After each group of table 1 treats 4 courses for the treatment of respectively, Clinical efficacy comparison is routine

Group	Number of cases	Effective number	Significant figure	Invalid number	Total effective rate (%)
						Embodiment group 1	77	73	2	2	97.4％
Embodiment group 2	77	77	0	0	100％
						Embodiment group 3	77	76	1	0	100％
Matched group	77	40	21	16	79.2％

Table 2 Four composition is effective and efficiently individual quantity time comparative example (%) after not treating 4 courses for the treatment of

Group	Number of cases	1st course for the treatment of	2nd course for the treatment of	3rd course for the treatment of	4th course for the treatment of
						Embodiment group 1	75	17（22.7％）	18（24％）	19（25.3％）	21（28％）
Embodiment group 2	77	17（22.1％）	19（24.7％）	20（26％）	21（27.3％）
						Embodiment group 3	77	17（22.1％）	19（24.7％）	20（26％）	21（27.3％）
Matched group	61	5（8.2％）	7（11.5％）	10（16.4％）	39（63.9％）

According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, have no side effect; 229 example and the effective and effective 61 routine follow-up of patients 1 year half of matched group of and efficiently individual quantity effective to treatment group simultaneously, result is added up, and in embodiment group 1 treatment group 75 example, effective 73 examples are all without recurring, 1 case relapsed in effective 2 examples, and relapse rate is 1.3%; In embodiment group 2 treatment group 77 example, effective 77 examples are all without recurrence, and relapse rate is 0%; In embodiment group 3 treatment group 77 example effective 76 and effective 1 example in all without recurrence, relapse rate is 0%; Matched group is effective and efficiently individual quantity 61 routine, recurs 17 examples in effective 40 routine patients, recurs 11 examples, relapse rate 45.9% in effective 21 routine patients; Above-mentioned recurrence refer to patient outcomes reach effective or effectively after, in 1 year half of following up a case by regular visits to, obviously there is the symptom before treatment.

Model case: shut out certain, male 52 years old, lumbosacral region, hip are ached a year and a half, also have pain night once in a while, alleviate after movable, also with heel and other tendon attachment points pain, through being diagnosed as ankylosing spondylitis.Use the unguentum of embodiment of the present invention group 1, every day 3 times, each 6g 30 days is a course for the treatment of, and medication is substantially effective for a course for the treatment of, continues medication two weeks effective, follows up a case by regular visits to and do not recur for 1 year half.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (9)

1. treat the medicine of ankylosing spondylitis for one kind, it is characterized in that, comprise following raw medicinal material: Herba Scleriae Terrestris, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Lycii, Cortex Lycii, Herba Arthraxonis Hispidi, Radix Rubiae, Herba Selaginellae Moellendorfii, Pollen Typhae, Ramulus Cinnamomi, Radix Rhapontici, Rhizoma Chuanxiong, Radix berchemiae lineatae, Herba Ajugae Lupulinae, Radix Seu Caulis Mucunae Sempervirentis, Rhizoma Sparganii, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm., Radix seu Cortex Heteropanacis, Herba pratiae begonifoliae, Radix et rhizoma smilacinae japonicae, Radix Dipsaci, Radix Achyranthis Bidentatae and Herba Lycopodii.

2. the medicine for the treatment of ankylosing spondylitis according to claim 1, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Scleriae Terrestris 15 ~ 45 parts, 3 ~ 5 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Lycii 12 ~ 32 parts, Cortex Lycii 10 ~ 20 parts, Herba Arthraxonis Hispidi 15 ~ 35 parts, Radix Rubiae 11 ~ 21 parts, Herba Selaginellae Moellendorfii 10 ~ 42 parts, Pollen Typhae 12 ~ 22 parts, Ramulus Cinnamomi 10 ~ 30 parts, Radix Rhapontici 15 ~ 45 parts, Rhizoma Chuanxiong 13 ~ 33 parts, Radix berchemiae lineatae 15 ~ 25 parts, Herba Ajugae Lupulinae 12 ~ 32 parts, Radix Seu Caulis Mucunae Sempervirentis 11 ~ 21 parts, Rhizoma Sparganii 16 ~ 38 parts, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm. 15 ~ 46 parts, Radix seu Cortex Heteropanacis 2 ~ 4 parts, Herba pratiae begonifoliae 13 ~ 36 parts, Radix et rhizoma smilacinae japonicae 15 ~ 25 parts, Radix Dipsaci 12 ~ 32 parts, Radix Achyranthis Bidentatae 10 ~ 40 parts and Herba Lycopodii 14 ~ 28 parts.

3. the medicine for the treatment of ankylosing spondylitis according to claim 1 and 2, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Scleriae Terrestris 40 parts, 3 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Lycii 24 parts, Cortex Lycii 15 parts, Herba Arthraxonis Hispidi 32 parts, Radix Rubiae 15 parts, Herba Selaginellae Moellendorfii 36 parts, Pollen Typhae 14 parts, Ramulus Cinnamomi 25 parts, Radix Rhapontici 42 parts, Rhizoma Chuanxiong 23 parts, Radix berchemiae lineatae 17 parts, Herba Ajugae Lupulinae 30 parts, Radix Seu Caulis Mucunae Sempervirentis 14 parts, Rhizoma Sparganii 25 parts, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm. 42 parts, Radix seu Cortex Heteropanacis 3 parts, Herba pratiae begonifoliae 34 parts, Radix et rhizoma smilacinae japonicae 22 parts, Radix Dipsaci 28 parts, Radix Achyranthis Bidentatae 40 parts and Herba Lycopodii 20 parts.

4. the medicine of the treatment ankylosing spondylitis according to any one of claim 1-3, is characterized in that, in described medicine, each raw medicinal material also comprises: Rhizoma Iridis Tectori, Fructus Leonuri, Herba Stachytarphetae Jamaicensis, Radix Patriniae heterophyllae and Rhizoma Homalomenae.

5. the medicine of the treatment ankylosing spondylitis according to any one of claim 1-4, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Scleriae Terrestris 15 ~ 45 parts, 3 ~ 5 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Lycii 12 ~ 32 parts, Cortex Lycii 10 ~ 20 parts, Herba Arthraxonis Hispidi 15 ~ 35 parts, Radix Rubiae 11 ~ 21 parts, Herba Selaginellae Moellendorfii 10 ~ 42 parts, Pollen Typhae 12 ~ 22 parts, Ramulus Cinnamomi 10 ~ 30 parts, Radix Rhapontici 15 ~ 45 parts, Rhizoma Chuanxiong 13 ~ 33 parts, Radix berchemiae lineatae 15 ~ 25 parts, Herba Ajugae Lupulinae 12 ~ 32 parts, Radix Seu Caulis Mucunae Sempervirentis 11 ~ 21 parts, Rhizoma Sparganii 16 ~ 38 parts, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm. 15 ~ 46 parts, Radix seu Cortex Heteropanacis 2 ~ 4 parts, Herba pratiae begonifoliae 13 ~ 36 parts, Radix et rhizoma smilacinae japonicae 15 ~ 25 parts, Radix Dipsaci 12 ~ 32 parts, Radix Achyranthis Bidentatae 10 ~ 40 parts, Herba Lycopodii 14 ~ 28 parts, Rhizoma Iridis Tectori 3 ~ 4 parts, Fructus Leonuri 15 ~ 35 parts, Herba Stachytarphetae Jamaicensis 11 ~ 21 parts, Radix Patriniae heterophyllae 16 ~ 42 parts and Rhizoma Homalomenae 12 ~ 22 parts.

6. the medicine of the treatment ankylosing spondylitis according to any one of claim 1-5, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Scleriae Terrestris 40 parts, 3 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Lycii 24 parts, Cortex Lycii 15 parts, Herba Arthraxonis Hispidi 32 parts, Radix Rubiae 15 parts, Herba Selaginellae Moellendorfii 36 parts, Pollen Typhae 14 parts, Ramulus Cinnamomi 25 parts, Radix Rhapontici 42 parts, Rhizoma Chuanxiong 23 parts, Radix berchemiae lineatae 17 parts, Herba Ajugae Lupulinae 30 parts, Radix Seu Caulis Mucunae Sempervirentis 14 parts, Rhizoma Sparganii 25 parts, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm. 42 parts, Radix seu Cortex Heteropanacis 3 parts, Herba pratiae begonifoliae 34 parts, Radix et rhizoma smilacinae japonicae 22 parts, Radix Dipsaci 28 parts, Radix Achyranthis Bidentatae 40 parts, Herba Lycopodii 20 parts, Rhizoma Iridis Tectori 3 parts, Fructus Leonuri 26 parts, Herba Stachytarphetae Jamaicensis 14 parts, Radix Patriniae heterophyllae 32 parts and Rhizoma Homalomenae 18 parts.

7. the medicine of the treatment ankylosing spondylitis according to any one of claim 1-6, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Scleriae Terrestris 35 parts, 4 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Lycii 20 parts, Cortex Lycii 18 parts, Herba Arthraxonis Hispidi 25 parts, Radix Rubiae 20 parts, Herba Selaginellae Moellendorfii 32 parts, Pollen Typhae 16 parts, Ramulus Cinnamomi 23 parts, Radix Rhapontici 34 parts, Rhizoma Chuanxiong 20 parts, Radix berchemiae lineatae 25 parts, Herba Ajugae Lupulinae 16 parts, Radix Seu Caulis Mucunae Sempervirentis 15 parts, Rhizoma Sparganii 28 parts, Tripterospermum cordatum(Hand.-Mazz. Ex H. Sm.) H. Sm. 36 parts, Radix seu Cortex Heteropanacis 3 parts, Herba pratiae begonifoliae 30 parts, Radix et rhizoma smilacinae japonicae 18 parts, Radix Dipsaci 24 parts, Radix Achyranthis Bidentatae 30 parts, Herba Lycopodii 24 parts, Rhizoma Iridis Tectori 3 parts, Fructus Leonuri 32 parts, Herba Stachytarphetae Jamaicensis 16 parts, Radix Patriniae heterophyllae 40 parts and Rhizoma Homalomenae 22 parts.

8. the preparation method of the medicine of the treatment ankylosing spondylitis according to any one of claim 1-7, is characterized in that, when the dosage form of described medicine is unguentum, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;

Second step, stearic acid heating dissolved, remaining on temperature is 70 DEG C ~ 80 DEG C, obtains stearic acid liquid; In addition, potassium hydroxide, glycerol, ethyl hydroxybenzoate and distilled water are mixed in proportion, heating, maintains the temperature at 70 DEG C ~ 80 DEG C, obtains distilled water mixed liquor; Stearic acid liquid is slowly joined in distilled water mixed liquor, stirs cooling simultaneously, obtain substrate;

3rd step, joins the Chinese medicinal powder that the first step obtains in the substrate of second step acquisition and is also constantly ground to evenly, obtain unguentum.

9. the preparation method of the medicine of the treatment ankylosing spondylitis according to any one of claim 1-7, is characterized in that, when the dosage form of described medicine is granule, its preparation method comprises the following steps:

The first step, each for described medicine raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, is ground into powder subsequently, makes dried cream powder;

Second step, adds the dextrin of cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times, makes granule in the dried cream powder obtained, and in 40 ~ 50 DEG C of dryings, obtains granule.