WO2019104931A1

WO2019104931A1 - Traditional chinese medicine composition for treating leukaemia and preparation method therefor

Info

Publication number: WO2019104931A1
Application number: PCT/CN2018/083122
Authority: WO
Inventors: 毛小达
Original assignee: 毛小达
Priority date: 2017-11-30
Filing date: 2018-04-13
Publication date: 2019-06-06
Also published as: CN107753602A

Abstract

A traditional Chinese medicine composition for treating leukaemia, comprising the following components in parts by weight: 5-40 parts of cherokee rose root, 5-60 parts of Melastoma candidum root, 5-50 parts of Ficus hirta root, 5-50 parts of white pomegranate root, and 5-60 parts of lard. By means of the synergistic action of the components, the present composition is applied to high or low platelet indices and, on the basis of treating the function of the five internal organs in traditional Chinese medicine, recovers the hematopoietic system in the body, improving the adjustment of blood indicators to maintain normal levels.

Description

Traditional Chinese medicine composition for treating leukemia and preparation method thereof

Technical field

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating leukemia and a preparation method thereof.

Background technique

Leukemia is mainly a malignant disease of the hematopoietic system and is one of the top ten high-grade malignant tumors in China. It is characterized by unrestricted proliferation of a large number of leukemia cells in bone marrow and other hematopoietic tissues, and enters peripheral blood, and the production of normal blood cells is significantly inhibited. As far as the early treatment of leukemia is concerned, the clinical practice advocates comprehensive treatment, in which chemotherapy is the main method, and it can be combined with traditional Chinese medicine treatment to reduce toxicity and increase efficiency. The condition allows bone marrow transplantation to be used, which can play a radical role. Chemotherapy is an important method for the early treatment of leukemia, which can effectively relieve symptoms and prolong survival, and chemotherapy is also a necessary step before bone marrow transplantation. From the current treatment plan, chemotherapy is an important means, and it is still necessary to change the stem cells in the later stage. The chemotherapy process causes the body's immunosuppression, gastrointestinal inhibition, and the toxic side effects on the human body are very large.

Summary of the invention

A first object of the present invention is to solve the above problems and to provide a traditional Chinese medicine composition which can effectively treat leukemia.

The technical solution adopted to achieve the first purpose is:

A traditional Chinese medicine composition for treating leukemia, comprising the following components by weight: 5-40 parts of sakura root, 5-60 parts of wild peony root, 5-50 parts of five-finger peach root, 5-50 parts of white flower pomegranate root and lard 5 to 60 servings.

Golden Sakura Root, Rosaceae Evergreen climbing plant, alias: Golden Sakura, Biantang, is the root or root bark of the Rosaceae plant Rosa laevigata. It is often used for solidifying and urinating, sputum and diarrhea, and has the effect of treating kidney deficiency and turbidity.

The wild peony root is the root of the wild peony of the wild peony family. It has the functions of strengthening the spleen and dampness, promoting blood circulation and stopping bleeding. It treats indigestion, stomach pain, writing phlegm, blood in the stool, blood stasis, menorrhagia, rheumatism and bruises.

The roots of the five-pointed peach, the genus Castanopsis, are the roots of the genus Eucalyptus, which are born in the bushes of hillsides, valleys and roadsides, and distributed in the south and southwest of China. It has the effect of strengthening the spleen and replenishing the lungs.

White flower pomegranate root, pomegranate family is a pomegranate family, is the pomegranate plant white pomegranate or double petal white pomegranate root. Role: Qingrejiedu, Xiaotan Sanjie, Lishui swelling.

Lard, sweet, cool, non-toxic; has the effect of tonic, moistening and detoxification.

Preferably, a traditional Chinese medicine composition for treating leukemia comprises the following components by weight: 8 parts of sakura root, 15 parts of wild peony root, 8 parts of peony root, 8 parts of white pomegranate root and 8 parts of lard.

Preferably, if the patient is accompanied by hypertension, the following parts by weight of the component is added to the traditional Chinese medicine composition for treating leukemia: 5 to 40 parts of jelly grass.

Cool grass, alias: fairy grass, immortal grass, immortal frozen, pay grass, is the whole grass of the Labiatae plant, distributed in southern China, produced in Guangdong. It has the effects of clearing heat, quenching thirst and removing heat. Heat stroke, diabetes, high blood pressure, muscle and joint pain.

Preferably, a traditional Chinese medicine composition for treating leukemia comprises the following components by weight: 8 parts of sakura root, 15 parts of wild peony root, 10 parts of jelly grass, 8 parts of peony root, 8 parts of white flower pomegranate root and lard 8 copies.

Preferably, if the patient has low white blood cells or insufficient blood, the following parts by weight are added to the traditional Chinese medicine composition for treating leukemia: 5 to 40 parts of red dates, 5 to 40 parts of astragalus, 1 to 40 parts of Cistanche, red 1 to 40 parts, 1 to 40 parts of hawthorn, 5 to 40 parts of buds, 5 to 40 parts of clams, and 1 to 40 parts of almonds.

Jujube has the effect of replenishing vital energy, nourishing blood, soothing the nerves, strengthening the spleen and stomach. Treating spleen and dysfunction, lack of energy, and women's viscera. It is a good health and nutrition product for patients with weak spleen and stomach, lack of blood, fatigue, and insomnia.

Astragalus, also known as Beibei, is the dry root of the leguminous Mongolian Astragalus or Astragalus membranaceus. There are qi and solid table, diuretic swelling, toxic and drainage, and sore muscles. It has enhanced immune function, liver protection, diuretic, anti-aging, anti-stress, antihypertensive and a wide range of antibacterial effects.

Cistanche is a fleshy stem of Cistanche tubulosa or Cistanche, Cistanche. There are kidney, essence, moistening, smoothing effect, attending men's impotence, women's infertility, taking down, blood collapse, cold waist and knee pain, blood and constipation.

Red ginseng, red ginseng is also called round ginseng, ginseng, red ginseng's effect is to make up the vital energy, Fumai Gutuan, Yiqi blood, the role of red ginseng is qi, nourishing yin, benefiting blood, Shengjin, strong heart, Stomach, calm, cure physical weakness, limb cold pulse, gas does not take blood, uterine bleeding, heart failure, cardiogenic shock.

Hawthorn, the fruit for medicinal purposes, has the function of digestion and stomach, blood circulation, convergence and stagnation. It has curative effects on meat accumulation, phlegm, phlegm, diarrhea, diarrhea, low back pain, postpartum pillow pain, incomplete eclipse, and stagnation of pediatric milk.

Valley buds, alias glutinous rice, gluten, rice blast, rice buds. Efficacy: digestion and accumulation, spleen appetizer. Treatment of food stagnation, full of diarrhea, spleen and less food, athlete's foot edema.

The clam shell is the dry immature fruit of the citrus plant lime and its cultivar. The effect of the clam shell is to break the gas, sputum and eliminate the product. The role of the clam shell is to cure the chest, the ribs, the pain, and the food. Not.

Almonds have the effect of nourishing the lungs, relieving cough and relieving asthma, and relaxing the bowels. Indications of fatigue, cough, asthma, chest and abdomen, nausea, constipation, constipation, dry stool.

Preferably, a traditional Chinese medicine composition for treating leukemia comprises the following components by weight: 8 parts of sakura root, 15 parts of wild peony root, 8 parts of peony root, 8 parts of white flower pomegranate root, 8 parts of red date, 8 parts of scutellaria 8 parts of Cistanche, 8 parts of red ginseng, 8 parts of hawthorn, 8 parts of bud, 8 parts of clam shell, 8 parts of almond and 8 parts of lard.

Preferably, a traditional Chinese medicine composition for treating leukemia of the present invention can be directly ground into a powder or extracted and purified as a therapeutic component of a therapeutic composition by a conventional extraction technique such as an aqueous alcohol extraction method or an alcohol extraction method. The active ingredient can be combined with a pharmaceutically acceptable carrier or excipient. Wherein the pharmaceutically acceptable carrier or excipient is selected depending on the dosage form. The traditional Chinese medicine composition of the present invention is prepared into a tablet, a pill, a tea, a capsule or a syrup.

A second object of the present invention is to provide a process for the preparation of a traditional Chinese medicine composition for treating leukemia.

The technical solution adopted for the second purpose is:

A preparation method of a traditional Chinese medicine composition for treating leukemia, comprising the following steps:

S1, cleaning and sterilizing each component in the traditional Chinese medicine composition;

S2, the components are mixed, and then coarsely crushed into powder, and the fine number of the powder is 100 to 150 mesh;

S3, the coarsely crushed powder is put into a superfine airflow pulverizer and pulverized to 1000 to 2000 mesh;

S4, performing cell wall breaking treatment and biological extraction treatment;

S5, refining, and finally obtaining the product.

The beneficial effects of the invention are:

1. The traditional Chinese medicine composition for treating leukemia provided by the invention uses wild peony root as a monarch medicine, sakura root, lard, five-finger peach root and white flower pomegranate root as a medicine, and is applied to platelet index through synergistic action of each component. High or low, comprehensive adjustment and radical treatment of the spleen and kidney, according to the function of the five internal organs of traditional Chinese medicine, restore the body's hematopoietic system, improve the adjustment of blood various indicators, so that it maintains normal levels, and completely restore the hematopoietic function to the spleen.

2. The preparation method of the traditional Chinese medicine composition for treating leukemia provided by the invention, extracts the active ingredients of each component through a reasonable preparation process, reduces the loss of the active ingredient, and is simple and convenient to prepare.

Detailed ways

The present invention will be further described below in conjunction with specific embodiments:

Embodiment 1

The traditional Chinese medicine composition for treating leukemia provided by the present embodiment comprises the following components by weight: 8 parts of sakura root, 15 parts of wild peony root, 8 parts of peony root, 8 parts of white flower pomegranate root and 8 parts of lard.

Take the production of 1000Kg Chinese medicine composition as an example:

The above components are cleaned and sterilized, then mixed and coarsely crushed into 120 mesh powder, and then put into a superfine jet mill to be pulverized to 1000 mesh; then subjected to cell wall breaking treatment, and then put into an extracting solution for biological treatment. Extraction, refining, and finally metering.

Embodiment 2

The traditional Chinese medicine composition for treating leukemia provided by the present embodiment comprises the following components by weight: 8 parts of sakura root, 15 parts of wild peony root, 10 parts of jelly grass, 8 parts of peony root, 8 parts of white flower pomegranate root and 8 servings of lard.

Take the production of 1000Kg Chinese medicine composition as an example:

The above components are cleaned and sterilized, then mixed and coarsely crushed into 150 mesh powder, and then put into a superfine jet mill to be pulverized to 1500 mesh; then subjected to cell wall breaking treatment, and then put into an extracting solution for biological treatment. Extraction, refining, and finally metering.

Embodiment 3

The traditional Chinese medicine composition for treating leukemia provided by the present embodiment comprises the following components by weight: 25 parts of sakura root, 35 parts of wild peony root, 25 parts of jelly grass, 27 parts of five-finger peach root, 27 parts of white flower pomegranate root and 25 parts of lard.

Take the production of 1000Kg Chinese medicine composition as an example:

The above components are cleaned and sterilized, then mixed and coarsely crushed into 130 mesh powder, and then put into a superfine jet mill to be pulverized to 1700 mesh; then subjected to cell wall breaking treatment, and then put into the extracting solution for biological treatment. Extraction, refining, and finally metering.

Embodiment 4

The traditional Chinese medicine composition for treating leukemia provided by the present embodiment comprises the following components by weight: 8 parts of sakura root, 15 parts of wild peony root, 8 parts of peony root, 8 parts of white flower pomegranate root, 8 parts of red date, jaundice 8 parts, 8 parts of Cistanche, 8 parts of red ginseng, 8 parts of hawthorn, 8 parts of bud, 8 parts of clams, 8 parts of almonds and 8 parts of lard.

Take the production of 1000Kg Chinese medicine composition as an example:

The above components are cleaned and sterilized, then mixed and coarsely crushed into a 100-mesh powder, and then put into a superfine jet mill to be pulverized to 2000 mesh; then subjected to cell wall breaking treatment, and then put into an extracting solution for biological treatment. Extraction, refining, and finally metering.

Embodiment 5

The traditional Chinese medicine composition for treating leukemia provided by the present embodiment comprises the following components by weight: 35 parts of sakura root, 55 parts of wild peony root, 45 parts of five-finger peach root, 45 parts of white flower pomegranate root, 35 parts of red date, jaundice 35 parts, 35 parts of Cistanche, 35 parts of red ginseng, 35 parts of hawthorn, 35 parts of grain buds, 35 parts of clams, 35 parts of almonds and 50 parts of lard.

Take the production of 1000Kg Chinese medicine composition as an example:

The above components were extracted by the traditional Chinese medicine hot reflux low temperature extraction low temperature concentration unit extraction technology. The extraction technology of traditional Chinese medicine hot reflux low temperature extraction low temperature concentration unit is a combination of four extraction principles: decoction extraction, percolation extraction, countercurrent extraction and reflux extraction. The two processes of extraction and concentration of traditional Chinese medicine are carried out simultaneously, and the new process of extracting and concentrating traditional Chinese medicine is completed at one time, and the high-temperature boiling process of pressure and atmospheric pressure in the traditional extraction tank is changed, and the vacuum is used to lower the boiling point and low temperature extraction. Concentration, the working temperature in the extraction tank is controlled at 40 ° C ~ 100 ° C, the concentration temperature is controlled at 50 ° C ~ 80 ° C, due to the vacuum negative pressure, the Chinese herbal cells accelerate the expansion, forcing the cell membrane to rupture rapidly, so that the active ingredients in the cells continue Separation and dissolution. At the same time, the secondary steam generated by the extraction and concentration is introduced into the hot reflux condenser to form a hot condensate, and as a new solvent, it is continuously returned to the medicinal material in the extraction tank to maintain a high concentration difference, and the hot condensate continuously passes from top to bottom. The medicinal layer acts as a dynamic extraction of percolation, and then the extract is continuously introduced into the concentrator for concentration. According to many years of practical experience and research, under the action of negative pressure and low temperature vaporization heat, the greater the concentration difference, the higher the extraction rate of the active ingredient, and the refluxing hot condensate replaces the original solvent of the extraction tank in about 2 to 3 hours. Therefore, the solute in the medicinal material in the extraction tank and the solute in the eluate can maintain a higher concentration difference per unit time, and the extraction efficiency is higher.

Typical Case

First, Kang XX, male, 9 years old, in the third grade of primary school, the symptoms are limb weakness, mental illness, sleep, body weight loss, a small amount of rash on the surface of the skin.

The following is a comprehensive analysis of blood routine and bone marrow analysis in hospital examinations:

Comprehensive analysis of blood routine:

1, showing positive cells, positive pigmented anemia, red blood cells can be seen in blood, and red blood cells are reduced.

2, platelets: 10 × 109 / L, platelet size varies, deformed, platelets appear in the plate, the third function of coagulation abnormalities.

3. White blood cells: The number of white blood cells is 36×109/L.

Bone marrow analysis: The proportion of blast cells exceeds 40%.

Diagnosed as acute leukemia.

After taking the above traditional Chinese medicine composition for 1 month, the symptoms disappeared, and after 4 months of continued use, the hospital examined the report and returned to normal.

Second, Lin XX, male, 53 years old, general manager of a pharmaceutical company, showed weakness in four feet, joint pain, bleeding gums, difficulty walking, chemotherapy once, the skin was gray, the hospital was diagnosed as chronic myeloid leukemia. The patient is a drug, and he knows a lot of medicines himself. He thinks that this disease has no medicine. At the beginning, it was extremely uncooperative. Under the persuasion of the family, the dead horse was a living horse doctor. After taking the above traditional Chinese medicine composition for 1 month, the symptoms were alleviated a lot. After one and a half years of continuous use, the hospital examination was completely recovered.

Third, Zhang XX, male, 13 years old, showed symptoms of punctiform hemorrhage, persistent fever, bone tenderness, poor mental health, and a comprehensive blood test in the hospital one month after the onset:

2, platelets 8 × 109 / L, platelet size varies, deformed, there are giant platelets.

3. The number of white blood cells is 296×109/L.

4, color ultrasound shows hepatosplenomegaly.

Combined with microscopic examination of blood smear examination can be diagnosed as acute leukemia.

After taking the above traditional Chinese medicine composition for half a month, the symptoms were alleviated a lot. After 6 months of continuous use, the hospital checked various indicators to reach normal levels.

Those skilled in the art will appreciate that the embodiments described herein are intended to assist the reader in understanding the principles of the invention and the scope of the invention is not limited to the particular embodiments and embodiments. Various other specific modifications and combinations may be made without departing from the spirit and scope of the invention, and the modifications and combinations are still within the scope of the invention.

Claims

A traditional Chinese medicine composition for treating leukemia, comprising the following components by weight: 5-40 parts of sakura root, 5-60 parts of wild peony root, 5-50 parts of five-finger peach root, 5~50 of white flower pomegranate root 5 to 60 parts of lard and lard.
The traditional Chinese medicine composition for treating leukemia according to claim 1, comprising the following components by weight: 8 parts of sakura root, 15 parts of wild peony root, 8 parts of peony root, 8 parts of white flower pomegranate root and pig 8 parts of oil.
The traditional Chinese medicine composition for treating leukemia according to claim 1, which further comprises the following parts by weight: 5 to 40 parts of jelly grass.
The traditional Chinese medicine composition for treating leukemia according to claim 3, which comprises the following components by weight: 8 parts of sakura root, 15 parts of wild peony root, 10 parts of jelly grass, 8 parts of peony root, white pomegranate 8 parts of root and 8 parts of lard.
The traditional Chinese medicine composition for treating leukemia according to claim 1, further comprising the following components by weight: 5 to 40 parts of red dates, 5 to 40 parts of astragalus, 1 to 40 parts of Cistanche, and 1 to 40 parts of red ginseng 40 parts, 1 to 40 parts of hawthorn, 5 to 40 parts of buds, 5 to 40 parts of clams, and 1 to 40 parts of almonds.
The traditional Chinese medicine composition for treating leukemia according to claim 5, which comprises the following components by weight: 8 parts of sakura root, 15 parts of wild peony root, 8 parts of peony root, 8 parts of white flower pomegranate root, red date 8 parts, 8 parts of astragalus, 8 parts of Cistanche, 8 parts of red ginseng, 8 parts of hawthorn, 8 parts of bud, 8 parts of clams, 8 parts of almonds and 8 parts of lard.
The traditional Chinese medicine composition for treating leukemia according to any one of claims 1 to 6, wherein the traditional Chinese medicine composition is prepared into a tablet, a pill, a tea, a capsule or a syrup.
A method for preparing a traditional Chinese medicine composition for treating leukemia according to any one of claims 1 to 6, characterized in that it comprises the following steps:

S1, cleaning and sterilizing each component in the traditional Chinese medicine composition;

S2, the components are mixed, and then coarsely crushed into powder, and the fine number of the powder is 100 to 150 mesh;

S3, the coarsely crushed powder is put into a superfine airflow pulverizer and pulverized to 1000 to 2000 mesh;

S4, performing cell wall breaking treatment and biological extraction treatment;

S5, refining, and finally obtaining the product.