CN105250959A - Traditional Chinese medicine preparation for repairing liver damage and preparation method - Google Patents
Traditional Chinese medicine preparation for repairing liver damage and preparation method Download PDFInfo
- Publication number
- CN105250959A CN105250959A CN201510704045.1A CN201510704045A CN105250959A CN 105250959 A CN105250959 A CN 105250959A CN 201510704045 A CN201510704045 A CN 201510704045A CN 105250959 A CN105250959 A CN 105250959A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- chinese medicine
- medicine preparation
- repairing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 36
- 206010067125 Liver injury Diseases 0.000 title claims abstract description 9
- 231100000234 hepatic damage Toxicity 0.000 title abstract 6
- 230000008818 liver damage Effects 0.000 title abstract 6
- 208000006454 hepatitis Diseases 0.000 claims abstract description 11
- 206010008909 Chronic Hepatitis Diseases 0.000 claims abstract description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 40
- 231100000753 hepatic injury Toxicity 0.000 claims description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- 239000012141 concentrate Substances 0.000 claims description 20
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 14
- 241000180649 Panax notoginseng Species 0.000 claims description 14
- 239000008517 radix Trichosanthis Substances 0.000 claims description 13
- 238000011084 recovery Methods 0.000 claims description 11
- 239000000284 extract Substances 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 10
- 239000000341 volatile oil Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 6
- 239000006286 aqueous extract Substances 0.000 claims description 5
- 238000004821 distillation Methods 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- 239000012567 medical material Substances 0.000 claims description 4
- 231100000354 acute hepatitis Toxicity 0.000 claims description 3
- 230000001476 alcoholic effect Effects 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 6
- 230000006870 function Effects 0.000 abstract description 3
- 230000003285 pharmacodynamic effect Effects 0.000 abstract description 2
- 208000022309 Alcoholic Liver disease Diseases 0.000 abstract 1
- 244000236521 Bupleurum rotundifolium Species 0.000 abstract 1
- 235000015221 Bupleurum rotundifolium Nutrition 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 244000280244 Luffa acutangula Species 0.000 abstract 1
- 235000009814 Luffa aegyptiaca Nutrition 0.000 abstract 1
- 241000237502 Ostreidae Species 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 abstract 1
- 244000273928 Zingiber officinale Species 0.000 abstract 1
- 235000006886 Zingiber officinale Nutrition 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 235000008397 ginger Nutrition 0.000 abstract 1
- 210000005229 liver cell Anatomy 0.000 abstract 1
- 235000020636 oyster Nutrition 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 11
- 206010011224 Cough Diseases 0.000 description 9
- 235000009508 confectionery Nutrition 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 208000002193 Pain Diseases 0.000 description 7
- 231100000614 poison Toxicity 0.000 description 7
- 208000008454 Hyperhidrosis Diseases 0.000 description 6
- 206010037660 Pyrexia Diseases 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 206010007247 Carbuncle Diseases 0.000 description 5
- 210000000038 chest Anatomy 0.000 description 5
- 210000003494 hepatocyte Anatomy 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- 230000035900 sweating Effects 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 206010062717 Increased upper airway secretion Diseases 0.000 description 4
- 206010023126 Jaundice Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 208000026435 phlegm Diseases 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 230000002269 spontaneous effect Effects 0.000 description 4
- 239000003440 toxic substance Substances 0.000 description 4
- 206010000087 Abdominal pain upper Diseases 0.000 description 3
- 206010027514 Metrorrhagia Diseases 0.000 description 3
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 3
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 3
- 206010047700 Vomiting Diseases 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- -1 concentrated Substances 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 206010013990 dysuria Diseases 0.000 description 3
- 210000000232 gallbladder Anatomy 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 206010022437 insomnia Diseases 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 230000003908 liver function Effects 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 238000010298 pulverizing process Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000035922 thirst Effects 0.000 description 3
- 239000003053 toxin Substances 0.000 description 3
- 231100000765 toxin Toxicity 0.000 description 3
- 230000008673 vomiting Effects 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 2
- 201000000736 Amenorrhea Diseases 0.000 description 2
- 206010001928 Amenorrhoea Diseases 0.000 description 2
- 208000015220 Febrile disease Diseases 0.000 description 2
- 239000009636 Huang Qi Substances 0.000 description 2
- 208000019255 Menstrual disease Diseases 0.000 description 2
- 206010062575 Muscle contracture Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 206010043458 Thirst Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 231100000540 amenorrhea Toxicity 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 208000013116 chronic cough Diseases 0.000 description 2
- 208000006111 contracture Diseases 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 208000001780 epistaxis Diseases 0.000 description 2
- 208000035861 hematochezia Diseases 0.000 description 2
- 231100000283 hepatitis Toxicity 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000033386 Buerger disease Diseases 0.000 description 1
- 241000202726 Bupleurum Species 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 241001504664 Crossocheilus latius Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 206010014080 Ecchymosis Diseases 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 241000371997 Eriocheir sinensis Species 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 206010060710 Galactostasis Diseases 0.000 description 1
- 240000008397 Ganoderma lucidum Species 0.000 description 1
- 235000001637 Ganoderma lucidum Nutrition 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 206010020601 Hyperchlorhydria Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 208000008763 Mercury poisoning Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 206010029333 Neurosis Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 208000005374 Poisoning Diseases 0.000 description 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000004680 Rectal Fistula Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 241000195474 Sargassum Species 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 206010043540 Thromboangiitis obliterans Diseases 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 206010046814 Uterine prolapse Diseases 0.000 description 1
- 241000234314 Zingiber Species 0.000 description 1
- 206010002156 anal fistula Diseases 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000013219 diaphoresis Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 208000007386 hepatic encephalopathy Diseases 0.000 description 1
- 206010019692 hepatic necrosis Diseases 0.000 description 1
- 230000007866 hepatic necrosis Effects 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 206010019847 hepatosplenomegaly Diseases 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 230000008558 metabolic pathway by substance Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 208000015238 neurotic disease Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000003119 painkilling effect Effects 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 210000003240 portal vein Anatomy 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine preparation for repairing liver damage, and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine preparation for repairing the liver damage is prepared from 15-20 parts of Chinese thorowax roots, 6-10 parts of ramulus cinnamomi, 5-8 parts of dried ginger, 18-23 parts of radices trichosanthis, 10-16 parts of calcined oyster shells, 5-10 parts of honey-fried licorice roots, 5-10 parts of radix scutellariae, 12-16 parts of radix salviae miltiorrhizae, 8-12 parts of loofah sponges, 10-16 parts of herba artemisiae scopariae, 12-17 parts of rhizoma smilacis glabrae, 8-12 parts of pseudo-ginseng, 6-10 parts of folium isatidis, 8-16 parts of fructus schisandrae chinensis and 1-5 parts of rhizoma gastrodiae. The invention further provides a preparation method of the traditional Chinese medicine preparation. According to the traditional Chinese medicine preparation for repairing the liver damage, traditional Chinese medicine and pharmacy are combined with modern pharmacology and pharmacodynamics for compatibility, the curative effect is significant, untoward effects are few, damaged liver cells can be rapidly repaired, functions of the liver can be restored, the current problems and the root causes are eliminated simultaneously, and the traditional Chinese medicine preparation is suitable for liver damage, alcoholic liver damage and radiotherapy and chemotherapy liver damage which are caused by acute and chronic hepatitis.
Description
Technical field
The present invention relates to field of traditional Chinese, being specifically related to a kind of Chinese medicine preparation for repairing hepatic injury and preparation method.
Background technology
Liver is substantive body of gland maximum in human body, has very important and complicated physiological function.First be the maincenter of various substance metabolism and processing in human body, the nutrient substance that portal vein comes from intestinal absorption is processed, become the composition of oneself in human body and supply whole body, and unnecessary material is stored, as sugar, protein, fat; Again the metabolite that arterial blood is brought is carried out processing and utilization, or processed unavailable, then by kidney or biliary excretion, maintain and stable, the water-electrolyte balance of mediator's internal milieu and the stable of blood volume with this.Secondly, liver has biological conversion and function of detoxification, and all medicine or poisonous substances etc. entering human body, all can be oxidized at liver, reduce, be hydrolyzed, in conjunction with chemical reaction, to some extent by metabolism, excrete with the form of original shape or metabolite.Because hepatocyte constantly draws raw material from blood, be difficult to avoid to suffer noxious substance 43 or virus, toxin and parasitic infection or infringement, the lighter loses certain function, and severe one causes hepatic necrosis, finally develop into liver cirrhosis, hepatocarcinoma and liver failure, even hepatic encephalopathy occurs.
Ethanol, medicine, virus, chemicotherapy etc. all can cause hepatocyte injury in various degree.Serious is affected liver function by hepatocyte injury, therefore will carry out the reparation of hepatic injury cell after there is hepatocyte injury as early as possible.
Chaihu Guizhi Ganjiang Tang comes from the holy Zhang Zhongjing treatise on Febrile Diseases of doctor, be made up of Radix Bupleuri, Ramulus Cinnamomi, Rhizoma Zingiberis, radices trichosanthis, Radix Scutellariae, Concha Ostreae, Radix Glycyrrhizae, be used for the treatment of typhoid fever shaoyang disease, alternate attacks of chills and fever, cold reheat light, the micro-knot of neurosis, fullness in the chest and hypochondrium, dysuria, yearningly and not eh, sweating over the head only, vexed, male malaria much chills and a little fever, or no fever but chills.
The Chinese patent of application number 200810231003.0 discloses a kind of hepatitis B oral liquid, and crude drug is made up of Radix Bupleuri, Herba Artemisiae Annuae, Radix Platycodonis, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Medulla Tetrapanacis, Radix Scutellariae, Rhizoma Polygoni Cuspidati, Radix Panacis Quinquefolii, the Radix Astragali, Ganoderma lucidum seu Japonicum and Radix Salviae Miltiorrhizae.The Chinese patent of application number 201210229144.5 discloses a kind of Chinese medicine being used for the treatment of fatty liver, is prepared from: Radix Salviae Miltiorrhizae, Sargassum, Radix Bupleuri, Semen Cassiae, Rhizoma Polygoni Cuspidati, Rhizoma Alismatis by following medicine.
Not obvious to the therapeutic effect of hepatic injury in existing Chinese medicine preparation, and mostly can only the hepatic injury that causes of a kind of reason, to the hepatic injury caused by other reason and inefficacy, we need a kind ofly can treat hepatic injury caused by many reasons and medicine evident in efficacy simultaneously for this reason.
Summary of the invention
In order to solve the deficiencies in the prior art problem, the invention provides a kind of Chinese medicine preparation for repairing hepatic injury.The present invention is achieved by the following scheme:
A kind of Chinese medicine preparation for repairing hepatic injury, it is characterized in that: be prepared from by the medical material of following parts by weight, Radix Bupleuri 15 ~ 20 parts, Ramulus Cinnamomi 6 ~ 10 parts, Rhizoma Zingiberis 5 ~ 8 parts, Radix Trichosanthis 18 ~ 23 parts, Concha Ostreae (calcined) 10 ~ 16 parts, Radix Glycyrrhizae Preparata 5 ~ 10 parts, Radix Scutellariae 5 ~ 10 parts, Radix Salviae Miltiorrhizae 12 ~ 16 parts, Retinervus Luffae Fructus 8 ~ 12 parts, Herba Artemisiae Scopariae 10 ~ 16 parts, Rhizoma Smilacis Glabrae 12 ~ 17 parts, Radix Notoginseng 8 ~ 12 parts, Folium Isatidis 6 ~ 10 parts, Fructus Schisandrae Chinensis 8 ~ 16 parts, 1 ~ 5 part, Rhizoma Gastrodiae.
Preferably, the described Chinese medicine preparation for repairing hepatic injury is prepared from by the medical material of following parts by weight, Radix Bupleuri 16 parts, Ramulus Cinnamomi 8 parts, Rhizoma Zingiberis 6 parts, Radix Trichosanthis 20 parts, Concha Ostreae (calcined) 12 parts, Radix Glycyrrhizae Preparata 6 parts, Radix Scutellariae 8 parts, Radix Salviae Miltiorrhizae 15 parts, Retinervus Luffae Fructus 10 parts, Herba Artemisiae Scopariae 15 parts, Rhizoma Smilacis Glabrae 15 parts, Radix Notoginseng 10 parts, Folium Isatidis 8 parts, Fructus Schisandrae Chinensis 10 parts, 2 parts, Rhizoma Gastrodiae.
Further, the dosage form of the described Chinese medicine preparation for repairing hepatic injury is decoction, tablet, capsule or granule.
The hepatic injury caused for acute hepatitis, chronic hepatitis of hepatic injury of the present invention, alcoholic liver injury, chemicotherapy hepatic injury.
Present invention also offers the preparation method of the Chinese medicine preparation for repairing hepatic injury, its preparation process is as follows:
A. measure Radix Bupleuri by prescription, Ramulus Cinnamomi, Rhizoma Zingiberis, Radix Trichosanthis, Concha Ostreae (calcined), Radix Notoginseng, Rhizoma Gastrodiae pulverize, drop in extractor and add 2 ~ 5 times of water backflow 2h, release extracting solution, the soak by water 2 ~ 3 times of 2 ~ 5 times is added again, extracting liquid filtering, merging filtrate in medicinal residues, concentrated, concentrate is for subsequent use;
B. by prescription measure Radix Salviae Miltiorrhizae, Retinervus Luffae Fructus, Folium Isatidis, Fructus Schisandrae Chinensis pulverize add 5 ~ 10 chloroform extraction, release chloroform extracted solution, by chloroform extracted solution filter after, concentration and recovery chloroform, concentrate is concentrated into dry, pulverizes, in 60 DEG C of vacuum drying 8h, for subsequent use;
C. Rhizoma Smilacis Glabrae distillation extraction, obtains volatile oil; Released by aqueous extract, filter, concentrated filtrate is standby; In medicinal residues, add 3 ~ 5 times of alcohol heating reflux extract 2h, release alcohol extract, concentration and recovery ethanol, concentrate is for subsequent use;
D. the concentrate in a, b, c being walked and volatile oil merge, and mixing, adds pharmaceutically acceptable adjuvant.
The present invention's herbal nature used is as follows:
Radix Bupleuri: be umbelliferae bupleurum or the dry root of Radix Bupeuri Scorzonerfolii., pungent, bitter, be slightly cold.Return liver, gallbladder, lung meridian; There is evacuation bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.
Radix Scutellariae: be the dry root of labiate Radix Scutellariae.Bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.There is heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, heat-damp in summer, vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle poison.
Rhizoma Zingiberis: be the fresh rhizome of zingiber.Pungent, tepor.Return lung, spleen, stomach warp.Induce sweat cold expelling, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing, solving toxin of fish and crab.For anemofrigid cold, gastrofrigid vomiting, cold-phlegm is coughed, and fish Eriocheir sinensis is poisoning.
Ramulus Cinnamomi: warm in nature, acrid in the mouth, sweet.Diaphoresis expelling pathogenic factors from muscles, temperature three-way meridian.Be applicable to cold, cold rheumatalgia, shoulder arm be afraid of cold ache, deficient cold type menstruation is obstructed, stomach abdomen cold type of pain and the disease such as urine is not brisk and neat; Can be applicable to again chronic cough, cough up tell that the thin sputum of a large amount of white, health are weak, chest dull pain, cardiopalmus, brothers' often symptom such as warm.
Radix Trichosanthis: sweet, micro-hardship, is slightly cold.Attach to the lung and stomach meridians.Clearing away heat-fire, promoting the production of body fluid to quench thirst, detumescence and apocenosis.Calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.
Concha Ostreae (calcined): restrain astringent or styptic treatment for spontaneous sweating, relieving gastric hyperacidity to alleviate stomachache, tranquillization with heavy prescription, hard masses softening and resolving.The all cards of slippage (spontaneous perspiration, night sweat, frequent micturition, leukorrhagia, metrorrhagia, seminal emission etc.), stomachache pantothenic acid, irritability, insomnia, excessive rising of liver-YANG, has a dizzy spell.Strengthen arresting sweating and strengthening superficial resistance effect Concha Ostreae (calcined) can with the Radix Astragali, Radix Ephedrae, Fructus Tritici Levis is compatible.With Radix Saposhnikoviae, the Rhizoma Atractylodis Macrocephalae is compatible stopping perspiration with astringents, effect of dispelling wind to relieve the exterior syndrome.
Radix Glycyrrhizae Preparata: Qi-tonifying drug.Sweet in the mouth, property is put down.Energy invigorating the spleen and replenishing QI, eliminating phlegm and stopping cough, heat-clearing and toxic substances removing, emergency analgesic therapy, the mediation property of medicine.For contraction in weakness of the spleen and stomach, deficiency of QI in middle-JIAO, cough and asthma, skin sore, abdomen anxious to have a pain etc. disease and relax medicine strong, separate poison of drug etc.
Radix Salviae Miltiorrhizae: cold nature, bitter in the mouth.GUIXIN, Liver Channel.Drug for invigorating blood circulation and eliminating stasis.Promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, tranquilizing by nourishing the heart.Clinical practice: menoxenia, amenorrhea dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, neurasthenia, dysphoria and insomnia, angina pectoris, hepatosplenomegaly, carbuncle erysipelas.For unresolved and chronic hepatitis, thromboangiitis obliterans curative effect is obvious.
Retinervus Luffae Fructus: sweet in the mouth, cool in nature.Return lung, liver, stomach warp.The light tonneau of body.Dredge the meridian passage, heat-clearing and toxic substances removing, inducing diuresis to remove edema, hemostasis.Cure mainly distending pain in the chest and hypochondrium, rheumatic arthralgia, the contracture of muscle arteries and veins, woman's amenorrhea, galactostasis, phlegm-heat cough, pyretic toxicity carbuncle, anal fistula, edema, dysuria, has blood in stool, metrorrhagia.
Herba Artemisiae Scopariae: bitter, pungent, is slightly cold.Return spleen, stomach, liver, gallbladder meridian.Clearing away heat-damp and promoting diuresis; Jaundice eliminating.Cure mainly: jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis.
Rhizoma Smilacis Glabrae: sweet in the mouth, light, property is put down.Have removing toxic substances, dehumidifying, effect of easing joint movement, is mainly used in the limbs contracture caused by syphilis and mercurialism, bones and muscles pain; Damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula, scabies.
Radix Notoginseng: hemorrhage.Warm in nature, sweet in the mouth, micro-hardship.Dissipating blood stasis hemostasis, subduing swelling and relieving pain.For spitting of blood, haematemesis, epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage, the twinge of breast abdomen blood stasis, tumbling and swelling and carbuncle; Smash fried rear stone roller powder (cooked Radix Notoginseng powder), can benefiting blood and regulating blood circulation, for losing blood, anemia.
Folium Isatidis: heat and toxic materials clearing away medicine.Cold in nature, bitter in the mouth.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.For the high heat of epidemic febrile disease, coma, send out speckle dermexanthesis etc.
Fructus Schisandrae Chinensis: warm in nature, sour in the mouth, sweet.Astringency, can restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, spontaneous sweating, hepatitis, Tianjin wound is thirsty, interior-heat is quenched one's thirst, palpitation and insomnia
Rhizoma Gastrodiae: property is put down, sweet in the mouth, suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion.
The present invention selects pure Chinese crude drug to be raw material, compatibility is carried out in conjunction with modern pharmacology, pharmacodynamics by Chinese medicine, evident in efficacy, untoward reaction is few, and the hepatocyte of the quick repairing damage of energy, makes liver restore funcitons, treating both the principal and secondary aspects of a disease, be applicable to the hepatic injury that acute hepatitis, chronic hepatitis causes, alcoholic liver injury, chemicotherapy hepatic injury.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1: a kind of Chinese medicine preparation for repairing hepatic injury, is made up of following Chinese crude drug: Radix Bupleuri 15 parts, Ramulus Cinnamomi 6 parts, Rhizoma Zingiberis 5 parts, Radix Trichosanthis 18 parts, Concha Ostreae (calcined) 10 parts, Radix Glycyrrhizae Preparata 5 parts, Radix Scutellariae 5 parts, Radix Salviae Miltiorrhizae 12 parts, Retinervus Luffae Fructus 8 parts, Herba Artemisiae Scopariae 10 parts, Rhizoma Smilacis Glabrae 12 parts, Radix Notoginseng 8 parts, Folium Isatidis 6 parts, Fructus Schisandrae Chinensis 8 parts, 1 part, Rhizoma Gastrodiae.
For repairing the preparation method of the Chinese medicine preparation of hepatic injury, comprise the steps:
A. measure Radix Bupleuri 15kg, Ramulus Cinnamomi 6kg, Rhizoma Zingiberis 5kg, Radix Trichosanthis 18kg by prescription, forge
Concha Ostreae 10kg, Radix Notoginseng 8kg, Rhizoma Gastrodiae 1kg pulverize, and drop in extractor and add 126kg water backflow 2h, release extracting solution, then in medicinal residues, add 126kg soak by water 2 times, extracting liquid filtering, merging filtrate, concentrated, concentrate is for subsequent use;
B. measure Radix Salviae Miltiorrhizae 12kg, Retinervus Luffae Fructus 8kg by prescription, Folium Isatidis 6kg, Fructus Schisandrae Chinensis 8kg pulverizing adds 170kg chloroform extraction, release chloroform extracted solution, after chloroform extracted solution is filtered, concentration and recovery chloroform, concentrate is concentrated into dry, pulverizes, in 60 DEG C of vacuum drying 8h, for subsequent use;
C. fetch earth Poria 12kg distillation extraction, and obtain volatile oil, released by aqueous extract, filter, concentrated filtrate is standby; In medicinal residues, add 36kg alcohol heating reflux extract 2h, release alcohol extract, concentration and recovery ethanol, concentrate is for subsequent use;
D. the concentrate in a, b, c being walked and volatile oil merge, and mixing, adds dextrin and make granule.
Embodiment 2: a kind of Chinese medicine preparation for repairing hepatic injury, is made up of following Chinese crude drug: Radix Bupleuri 20 parts, Ramulus Cinnamomi 10 parts, Rhizoma Zingiberis 8 parts, Radix Trichosanthis 23 parts, Concha Ostreae (calcined) 16 parts, Radix Glycyrrhizae Preparata 10 parts, Radix Scutellariae 10 parts, Radix Salviae Miltiorrhizae 16 parts, Retinervus Luffae Fructus 12 parts, Herba Artemisiae Scopariae 16 parts, Rhizoma Smilacis Glabrae 17 parts, Radix Notoginseng 12 parts, Folium Isatidis 10 parts, Fructus Schisandrae Chinensis 16 parts, 5 parts, Rhizoma Gastrodiae.
For repairing the preparation method of the Chinese medicine preparation of hepatic injury, comprise the steps:
A. measure Radix Bupleuri 20kg, Ramulus Cinnamomi 10kg, Rhizoma Zingiberis 8kg, Radix Trichosanthis 23kg by prescription, forge
Concha Ostreae 16kg, Radix Notoginseng 12kg, Rhizoma Gastrodiae 5kg pulverize, and drop in extractor and add 470kg water backflow 2h, release extracting solution, then in medicinal residues, add 470kg soak by water 2 times, extracting liquid filtering, merging filtrate, concentrated, concentrate is for subsequent use;
B. measure Radix Salviae Miltiorrhizae 16kg, Retinervus Luffae Fructus 12kg by prescription, Folium Isatidis 10kg, Fructus Schisandrae Chinensis 16kg pulverizing adds 540kg chloroform extraction, release chloroform extracted solution, after chloroform extracted solution is filtered, concentration and recovery chloroform, concentrate is concentrated into dry, pulverizes, in 60 DEG C of vacuum drying 8h, for subsequent use;
C. fetch earth Poria 17kg distillation extraction, and obtain volatile oil, released by aqueous extract, filter, concentrated filtrate is standby; In medicinal residues, add 85kg alcohol heating reflux extract 2h, release alcohol extract, concentration and recovery ethanol, concentrate is for subsequent use;
D. the concentrate in a, b, c being walked and volatile oil merge, and mixing, adds sugarcane sugar and starch and be pumped into tablet.
Embodiment 3: a kind of Chinese medicine preparation for repairing hepatic injury, by following Chinese crude drug group
Become: Radix Bupleuri 16 parts, Ramulus Cinnamomi 8 parts, Rhizoma Zingiberis 6 parts, Radix Trichosanthis 20 parts, Concha Ostreae (calcined) 12 parts, Radix Glycyrrhizae Preparata 6 parts, Radix Scutellariae 8 parts, Radix Salviae Miltiorrhizae 15 parts, Retinervus Luffae Fructus 10 parts, Herba Artemisiae Scopariae 15 parts, Rhizoma Smilacis Glabrae 15 parts, Radix Notoginseng 10 parts, Folium Isatidis 8 parts, Fructus Schisandrae Chinensis 10 parts, 2 parts, Rhizoma Gastrodiae.
For repairing the preparation method of the Chinese medicine preparation of hepatic injury, comprise the steps:
A. measure Radix Bupleuri 16kg, Ramulus Cinnamomi 8kg, Rhizoma Zingiberis 6kg, Radix Trichosanthis 20kg by prescription, forge
Concha Ostreae 12kg, Radix Notoginseng 10kg, Rhizoma Gastrodiae 2kg pulverize, and drop in extractor and add 222kg water backflow 2h, release extracting solution, then in medicinal residues, add 222kg soak by water 2 times, extracting liquid filtering, merging filtrate, concentrated, concentrate is for subsequent use;
B. measure Radix Salviae Miltiorrhizae 15kg, Retinervus Luffae Fructus 10kg by prescription, Folium Isatidis 8kg, Fructus Schisandrae Chinensis 10kg pulverizing adds 258kg chloroform extraction, release chloroform extracted solution, after chloroform extracted solution is filtered, concentration and recovery chloroform, concentrate is concentrated into dry, pulverizes, in 60 DEG C of vacuum drying 8h, for subsequent use;
C. fetch earth Poria 15kg distillation extraction, and obtain volatile oil, released by aqueous extract, filter, concentrated filtrate is standby; In medicinal residues, add 60kg alcohol heating reflux extract 2h, release alcohol extract, concentration and recovery ethanol, concentrate is for subsequent use;
D. the concentrate in a, b, c being walked and volatile oil merge, and mixing, adds PEG400 and make capsule.
Above embodiment is explanation of the present invention, is not limitation of the present invention, any inspiration according to the present invention make amendment, replace all belong to protection scope of the present invention.
Therapeutic effect of the present invention: the present invention have selected the patient 200 having hepatic injury made a definite diagnosis, and after taking Chinese medicine preparation of the present invention continuously, carries out liver function index detection, carries out efficacy determination.
(1) cure: patient clinical symptom all disappears, liver function recovery is normal, and health indices recovers normal on inspection.
(2) effective: patient clinical symptom major part disappears, and health indices is all close to normal value on inspection.
(3) effective: patient clinical symptom is slightly good, and health indices is all close to normal value on inspection.
(4) invalid: by treating rear clinical symptoms without significant change.
Result shows, and cures 139 examples, effective 40 examples, effective 19 examples, invalid 2 examples, cure rate 69.5%, total effective rate 99.0%.
Claims (5)
1. one kind for repairing the Chinese medicine preparation of hepatic injury, it is characterized in that: be prepared from by the medical material of following parts by weight, Radix Bupleuri 15 ~ 20 parts, Ramulus Cinnamomi 6 ~ 10 parts, Rhizoma Zingiberis 5 ~ 8 parts, Radix Trichosanthis 18 ~ 23 parts, Concha Ostreae (calcined) 10 ~ 16 parts, Radix Glycyrrhizae Preparata 5 ~ 10 parts, Radix Scutellariae 5 ~ 10 parts, Radix Salviae Miltiorrhizae 12 ~ 16 parts, Retinervus Luffae Fructus 8 ~ 12 parts, Herba Artemisiae Scopariae 10 ~ 16 parts, Rhizoma Smilacis Glabrae 12 ~ 17 parts, Radix Notoginseng 8 ~ 12 parts, Folium Isatidis 6 ~ 10 parts, Fructus Schisandrae Chinensis 8 ~ 16 parts, 1 ~ 5 part, Rhizoma Gastrodiae.
2. the Chinese medicine preparation for repairing hepatic injury according to claim 1, it is characterized in that: be prepared from by the medical material of following parts by weight, Radix Bupleuri 16 parts, Ramulus Cinnamomi 8 parts, Rhizoma Zingiberis 6 parts, Radix Trichosanthis 20 parts, Concha Ostreae (calcined) 12 parts, Radix Glycyrrhizae Preparata 6 parts, Radix Scutellariae 8 parts, Radix Salviae Miltiorrhizae 15 parts, Retinervus Luffae Fructus 10 parts, Herba Artemisiae Scopariae 15 parts, Rhizoma Smilacis Glabrae 15 parts, Radix Notoginseng 10 parts, Folium Isatidis 8 parts, Fructus Schisandrae Chinensis 10 parts, 2 parts, Rhizoma Gastrodiae.
3. the preparation method of the Chinese medicine preparation for repairing hepatic injury according to claim 1 and 2, is characterized in that:
Measure Radix Bupleuri by prescription, Ramulus Cinnamomi, Rhizoma Zingiberis, Radix Trichosanthis, Concha Ostreae (calcined), Radix Notoginseng, Rhizoma Gastrodiae pulverize, drop in extractor and add 2 ~ 5 times of water backflow 2h, release extracting solution, the soak by water 2 ~ 3 times of 2 ~ 5 times is added again, extracting liquid filtering, merging filtrate in medicinal residues, concentrated, concentrate is for subsequent use;
By prescription measure Radix Salviae Miltiorrhizae, Retinervus Luffae Fructus, Folium Isatidis, Fructus Schisandrae Chinensis pulverize add 5 ~ 10 chloroform extraction, release chloroform extracted solution, by chloroform extracted solution filter after, concentration and recovery chloroform, concentrate is concentrated into dry, pulverizes, in 60 DEG C of vacuum drying 8h, for subsequent use;
Rhizoma Smilacis Glabrae distillation extraction, obtains volatile oil; Released by aqueous extract, filter, concentrated filtrate is standby; In medicinal residues, add 3 ~ 5 times of alcohol heating reflux extract 2h, release alcohol extract, concentration and recovery ethanol, concentrate is for subsequent use;
Concentrate in a, b, c being walked and volatile oil merge, and mixing, adds pharmaceutically acceptable adjuvant.
4. the Chinese medicine preparation for repairing hepatic injury according to claim 1 and 2, is characterized in that: the dosage form of described Chinese medicine is decoction, tablet, capsule or granule.
5. the Chinese medicine preparation for repairing hepatic injury according to claim 1 and 2, is characterized in that: described hepatic injury is the hepatic injury that acute hepatitis, chronic hepatitis causes, alcoholic liver injury, chemicotherapy hepatic injury.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510704045.1A CN105250959A (en) | 2015-10-27 | 2015-10-27 | Traditional Chinese medicine preparation for repairing liver damage and preparation method |
| CN201610884414.4A CN106334171B (en) | 2015-10-27 | 2016-10-10 | A kind of Chinese medicine preparation and preparation method for being used to repair hepatic injury |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510704045.1A CN105250959A (en) | 2015-10-27 | 2015-10-27 | Traditional Chinese medicine preparation for repairing liver damage and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105250959A true CN105250959A (en) | 2016-01-20 |
Family
ID=55091085
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510704045.1A Pending CN105250959A (en) | 2015-10-27 | 2015-10-27 | Traditional Chinese medicine preparation for repairing liver damage and preparation method |
| CN201610884414.4A Active CN106334171B (en) | 2015-10-27 | 2016-10-10 | A kind of Chinese medicine preparation and preparation method for being used to repair hepatic injury |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610884414.4A Active CN106334171B (en) | 2015-10-27 | 2016-10-10 | A kind of Chinese medicine preparation and preparation method for being used to repair hepatic injury |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN105250959A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106334171A (en) * | 2015-10-27 | 2017-01-18 | 哈尔滨市康隆药业有限责任公司 | Traditional Chinese medicine preparation for repairing liver damage and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108813564A (en) * | 2018-05-24 | 2018-11-16 | 珠海赛隆药业股份有限公司 | There are the composition and health food of defencive function to chemical damage |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953924A (en) * | 2010-10-14 | 2011-01-26 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating chronic hepatitis |
| CN102228648A (en) * | 2011-06-27 | 2011-11-02 | 武红莲 | Chinese medicinal composition for treating icterohepatitis |
| CN102389542A (en) * | 2011-07-23 | 2012-03-28 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating chronic hepatitis |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105250959A (en) * | 2015-10-27 | 2016-01-20 | 哈尔滨市康隆药业有限责任公司 | Traditional Chinese medicine preparation for repairing liver damage and preparation method |
-
2015
- 2015-10-27 CN CN201510704045.1A patent/CN105250959A/en active Pending
-
2016
- 2016-10-10 CN CN201610884414.4A patent/CN106334171B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953924A (en) * | 2010-10-14 | 2011-01-26 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating chronic hepatitis |
| CN102228648A (en) * | 2011-06-27 | 2011-11-02 | 武红莲 | Chinese medicinal composition for treating icterohepatitis |
| CN102389542A (en) * | 2011-07-23 | 2012-03-28 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating chronic hepatitis |
Non-Patent Citations (2)
| Title |
|---|
| 梁瑞敏，张俊: "论治肝炎五法", 《中医药研究》 * |
| 麻林梅: "柴胡桂枝干姜汤治疗慢性肝炎46例", 《中国民间疗法》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106334171A (en) * | 2015-10-27 | 2017-01-18 | 哈尔滨市康隆药业有限责任公司 | Traditional Chinese medicine preparation for repairing liver damage and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106334171B (en) | 2017-09-12 |
| CN106334171A (en) | 2017-01-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103550517B (en) | A kind of medicine of Hepatoma therapy | |
| CN103432559B (en) | Traditional Chinese medicine composition for treating spanomenorrhea and dysmenorrhea caused by blood stasis and preparation method and application thereof | |
| CN102600426B (en) | Chinese medicinal preparation for promoting blood circulation to remove blood stasis and preparation method thereof | |
| CN105641466A (en) | Traditional Chinese medicine composition for invigorating kidney and strengthening yang and preparing method thereof | |
| CN105362937A (en) | Traditional Chinese medicine composition capable of effectively treating pulmonary tuberculosis and preparation method thereof | |
| CN104383317A (en) | Chinese traditional medicine composition for treating liver cancer | |
| CN104547778A (en) | Traditional Chinese medicine preparation for radiation protection in ultrasound department and preparation method of traditional Chinese medicine preparation | |
| CN103285343B (en) | Medicine for treating liver cancer and preparation method thereof | |
| CN105250959A (en) | Traditional Chinese medicine preparation for repairing liver damage and preparation method | |
| CN105079721A (en) | Traditional Chinese medicine composition for treating osteoarthritis and preparing method thereof | |
| CN104547369A (en) | Oral medicine for treating blepharospasm and preparation method thereof | |
| CN103656199B (en) | A kind of Chinese medicine for the treatment of deficiency of kidney yin syndrome cough | |
| CN103536892B (en) | Traditional Chinese medicine for treating infertility of syndrome of yang deficiency and coagulated cold | |
| CN103110911A (en) | Traditional Chinese medicine composition for treating coronary heart disease | |
| CN105688074A (en) | Decoction medicine for treating hypogastric pain and preparation method of decoction medicine | |
| CN106361881A (en) | Decoction medicament for treating scrotal eczema and preparation method of decoction medicament | |
| CN105125860A (en) | Preparation for effectively treating osteoporosis | |
| CN104689150A (en) | Traditional Chinese medicine preparation for treating diabetes | |
| CN105125836A (en) | Decoction medicament for treating erythema nodosum and preparation method thereof | |
| CN105169277A (en) | Fructus gardeniae oral liquid capable of protecting liver and benefiting gallbladder and preparation method thereof | |
| CN104524149A (en) | Pharmaceutical composition for preventing and treating acute nephritis and application thereof | |
| CN103623355B (en) | A kind of Chinese medicine preparation for the treatment of the oblique hernia of sliding | |
| CN108671112A (en) | A kind of Chinese medicine composition and preparation method thereof for treating liver-depression and spleen-insufficiency type oneself immunity hepatitis | |
| CN101912580A (en) | Chinese herbal medicament for treating abdominal pain of women before menses | |
| CN107789552A (en) | A kind of medicine for treating hepatitis B and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160120 |