CN105362810A - Drug combination for treating synovitis - Google Patents

Drug combination for treating synovitis Download PDF

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Publication number
CN105362810A
CN105362810A CN201510871949.3A CN201510871949A CN105362810A CN 105362810 A CN105362810 A CN 105362810A CN 201510871949 A CN201510871949 A CN 201510871949A CN 105362810 A CN105362810 A CN 105362810A
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synovitis
radix
pharmaceutical composition
rhizoma atractylodis
semen
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庞大坤
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Jinan Xingyi Medical Technology Co Ltd
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Jinan Xingyi Medical Technology Co Ltd
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Priority to CN201510871949.3A priority Critical patent/CN105362810A/en
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention discloses a drug combination for treating synovitis and a preparation method thereof. The drug combination is prepared by matching wintercherry, Cortex acanthopanacis, white atractylodes rhizome, Rhizoma atractylodis, pawpaw, Angelica sinensis, licorice root, Caulis spatholobi, Radix clematidis, Semen phaseoli, Radix paeoniae alba, Achyranthes bidentata, Cortex phellodendri, Coix seed, peach kernel, Safflower carthamus, Radix angelicae pubescentis and Portulaca oleracea which serve as active pharmaceutical ingredients. The drug combination has remarkable effect on treating synovitis.

Description

A kind of pharmaceutical composition for the treatment of synovitis
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of pharmaceutical composition for the treatment of synovitis and preparation method thereof.
Background technology
Synovitis is that synovial membrane is upset generation inflammation, causes juice to lack of proper care and forms a kind of arthropathy of hydrops.The quickening of rhythm of life, obtains synovitis number and also gets more and more.If treat patient not in time just there will be hydrarthrosis redness, distortion, heavy tingle, the symptoms such as many pains of being afraid of cold of limbs, but also knee-joint edema, pain, joint deformity can be caused, or even maimed.Current employing western medicine, such as: hormone, drawing liquid, rinses, the treatments such as antibiotic, though obtain some satisfied curative effects, treatment is not thorough, and the side effect of Western medicine is too many simultaneously, also very big to organ injury such as the heart, liver, kidneys.Up to the present, a kind of specific medicament thoroughly curing synovitis is not also found.The object of the present invention is to provide: a kind of short treating period (the 3-6 course for the treatment of), thoroughly cure, expense is low, recover after a kind of pharmaceutical composition for the treatment of various synovitis of advantage of not recurring, the various synovitis of disposable thorough elimination, can be used as at present state-of-the-art synovitis medicine in the world.
Calyx seu fructus physalis: for plant of Solanaceae Calyx seu fructus physalis has the herb of Calyx seu Fructus physalis (PhysalisalkekengiL.).[nature and flavor] sour in the mouth; Bitter; Cold in nature.[return through] returns lung; Spleen channel.[function cures mainly] heat clearing away poison; Throat smoothening secretion.Main laryngopharynx swelling and pain; Cough due to lung-heat; Jaundice; Dysentery; Edema; Urine leaching is puckery; Constipation; Impetigo; Eczema; Erysipelas.
Cortex Acanthopancis: this product is the dry root bark of Araliaceae acanthopanax gracilistylus AcanthopanaxgracilistylusW.W.Smith.Summer, Qiu Erji excavate root, clean, strip root bark, dry.[nature and flavor] are pungent, bitter, temperature.[return through] returns liver, kidney channel.[function cures mainly] wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening.For rheumatic arthralgia, muscles and bones flaccidity is soft, children's's walking retardation in children, and body void is weak, edema, beriberi.[character] this product is irregular drum, the thick about 0.2cm of long 5 ~ 15cm, diameter 0.4 ~ 1.4cm.Outer surface taupe, has the vertical wrinkle of slightly distortion and hole skin of growing crosswise; Faint yellow or the lark of inner surface, has thin longitudinal grin.Body is light, and matter is crisp, frangibility, and section is irregular, canescence.Feeble QI is fragrant, and taste is micro-peppery and bitter.
The Rhizoma Atractylodis Macrocephalae: this product is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae AtractylodesmacrocephalaKoidz..Excavate when withered and yellow, the upper leaf of inferior leads in winter becomes fragile, removing silt, dries or dries, then remove fibrous root.[meridian distribution of property and flavor] is bitter, sweet, temperature.Return spleen, stomach warp.[function cures mainly] invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.Have loose bowels for insufficiency of the spleen lack of appetite, abdominal distention, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.[chemical composition of Chinese materia medica]: containing volatile oil 1.4%, main component is atractylol (Atractylol), atractylone (Atractylon) etc., and containing vitamin A.Rhizome is containing volatile oil about 1.4%, containing atractylone (a-tractylone) in oil, still containing butenolide A, second (butenolideA, B), celery alkane dienone [selina-4 (14), 7 (11)-dien-8-one], β-celery oil alkene (β-Se-linene), Eucalyptus terpene (aromaden-drene); Another containing oxygen Coumarins (oxicoumarines), saccharide and resin etc.[character] rhizome is fist shape agglomerate, long 3 ~ 13cm, diameter 1.5 ~ 7cm.Surface lark or taupe brown, have strumae and interrupted vertical wrinkle and mark of fibrous root, there are residual stem foot and bud trace in top.Matter is hard, not frangibility, and section is uneven, and yellow-white, to light brown, has the point-like grease chamber of brown color to be dispersed in.Gas delicate fragrance, sweet in the mouth, micro-pungent, the somewhat viscous of chewing.
Rhizoma Atractylodis: this product is feverfew Atractylodes lancea (Thunb.) DC. Atractylodeslancea(Thunb.) DC. or Atractylis chinensis Atractylodeschinensis(DC.) dry rhizome of Koidz..Spring, Qiu Erji excavate, and removing silt, dries, hit fibrous root.[nature and flavor] are pungent, bitter, temperature.[return through] returns spleen, stomach, Liver Channel.[function cures mainly] is drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.[character] in irregular beaded or nodositas cylindrical, slightly bending, occasionally have branch, long 3 ~ 10cm, diameter 1 ~ 2cm.Surface taupe brown, has wrinkle, lateral flexure stricture of vagina and residual fibrous root, top tool stem trace or residual stem foot.Matter is solid, section yellow-white or canescence, and loose have most orange-yellow or brownish red grease chamber, exposes slightly of a specified duration, can separate out white fine needle crystal.Gas perfume (or spice) is special, and taste is micro-sweet, pungent, bitter.
Fructus Chaenomelis: this product is rosaceous plant chaenomeles lagenaria Chaenomelesspeciosa(Sweet) the dry almost ripe fruit of Nakai.Summer, autumn two gather when season, fruit was greenish-yellow, and put in boiling water and scald to crust canescence, double vertical profile, dries.[nature and flavor] acid, temperature.[return through] returns liver, spleen channel.[function cures mainly] suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.For arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, convulsion of vomiting and diarrhoea, beriberi edema.[character] this product Long Circle, many vertical profiles into two, grow 4 ~ 9cm, wide 2 ~ 5cm, thick 1 ~ 2.5cm。Outer surface aubergine or rufous, have irregular deep wrinkle; Profile edge is inwardly curling, sarcocarp rufous, and core caves in, brown color; Seed prolate triangle, comes off more.Matter is hard.Feeble QI delicate fragrance, sour in the mouth.
Radix Angelicae Sinensis: this product is umbelliferae angelica Angelicasinensis(Oliv.) dry root of Diels.Autumn end excavates, and removing fibrous root and silt, after moisture slightly evaporates, be bundled into wisp, upper canopy, with pyrotechnics slowly smoke-dried beancurd.[nature and flavor] sweet, acrid, warm.[return through] returns liver, the heart, spleen channel.[function cures mainly] is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume GlycyrrhizauralensisFisch., Glycyrrhiza inflata Bat. GlycyrrhizainflataBat. or Glycyrrhiza glabra L. GlycyrrhizaglabraL..Spring, Qiu Erji excavate, and removing fibrous root, dries.[nature and flavor]: (root) is sweet, flat, nontoxic.[return through]: enter spleen, stomach, lung meridian.[effect and effect]: QI invigorating invigorating middle warmer; Relieving spasm to stop pain; Nourishing the lung to arrest cough; Eliminating fire and detoxication; Coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite; Leanness yellowish complexion; Shortness of breath and palpitation; Stomachache loose stool; The anxious pain of extremity contraction; Hysteria; Cough and asthma; Laryngopharynx swelling and pain; Carbuncle skin ulcer swells and ache; Infantile carbuncle; And medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Caulis Spatholobi: be leguminous plant spatholobus suberectus spatholobussuberectusthe dry rattan of Dunn.Autumn, season in winter two gather, and removing branch and leaf, section, dries.Be distributed in the ground such as Guangdong, Guangxi, Yunnan.There is blood circulation promoting and enriching, menstruction regulating and pain relieving, effect of relaxing muscles and tendons and activating QI and blood in the collateral.For menoxenia, dysmenorrhea, amenorrhea, rheumatic arthralgia, paralysis and numbness, blood deficiency and yellow complexion.[meridian distribution of property and flavor]: bitter, sweet, temperature.Return liver, kidney channel.[function cures mainly]: enrich blood, invigorates blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
Radix Clematidis: this product is the dry root and rhizome of ranunculaceae plant Radix Clematidis ClematischinensisOsbeck, Clematis hexapetala ClematishexapetalaPall. or northeast clematis ClematismanshuricaRupr..There is expelling wind and removing dampness, effect of removing obstruction in the collateral to relieve pain.For rheumatic arthralgia, numb limbs and tense tendons, the contracture of muscle arteries and veins, joint stuffiness, bone is choked with sobs the diseases such as larynx.[nature and flavor] are pungent salty, temperature, poisonous.[function cures mainly] expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump.Cure mainly gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, chills and pain of the waist and kness, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.
Semen Phaseoli: be leguminous plant Semen Phaseoli vignaumbeuataOhwietOhashior Semen Phaseoli vignaangutarisOhwietOhashidry mature seed.Autumn fruit maturation and do not ftracture time to choose Herb, dry, lay seed, removing impurity, then dry.[nature and flavor] property is put down, and sweet in the mouth, acid [return through] enter the heart, small intestine meridian.[effect and effect] can inducing diuresis and reducing edema (jaundice, dysentery, has blood in stool, carbuncle for edema, beriberi), heat clearing away jaundice eliminating, removing toxic substances and promoting pus discharge.Diuresis is all useful to heart disease and nephropathy, edematous patient.
The Radix Paeoniae Alba: this product is the dry root of ranunculaceae plant Radix Paeoniae PaeonialactifloraPall..Summer, Qiu Erji excavate, and clean, and remove end to end and radicula, put in boiling water after boiling rear removing crust or peeling and boil, dry.[nature and flavor] picric acid is cool.[return through] enters liver, spleen channel.[effect and effect] has to enrich blood and adjusts the effect of blood, air making-up and spleen enlivening.
Radix Achyranthis Bidentatae: this product is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae AchyranthesbidentataBlume..Excavate when winter, stem and leaf was withered, removing fibrous root and silt, be bundled into wisp, shine to shriveling, trimmed on top, dry.[nature and flavor] are bitter, sour, flat.[return through] returns liver, kidney channel.[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.
Cortex Phellodendri: be rutaceae wampee phellodendronchinenseschneid. dry bark.Practise and claim " Cortex Phellodendri ".After stripping bark, removing rough bark, dries.[nature and flavor]: bitter; Cold.[return through]: kidney channel; Bladder; Large intestine channel.[effect and effect]: heat and toxic materials clearing away medicine; Heat clearing and dampness removing medicine.
Semen Coicis: this product is grass Semen Coicis Coixlacryma-jobiL.var.ma-yuen(Roman.) dry mature kernal of Stapf.Tap plant during fruit maturation in autumn, dry, lay fruit, then dry, except decapsidate, yellowish-brown seed coat and impurity, collect kernel.Being conventional Chinese medicine, is again the food generally, often eaten, and property slightly sweet flavor is slightly cold, and has inducing diuresis to remove edema, the effect such as spleen invigorating is dried, arthralgia relieving by relaxing muscles and tendons, clearing away heat and discharging pus, is conventional damp-clearing drug.[nature and flavor]: cool in nature, sweet in the mouth, light.[effect and effect] spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal.Semen Coicis can be used for treatment edema, beriberi, dysuria,
Semen Persicae: be rosaceous plant Fructus Persicae prunuspersica(L.) Batsch or Prunus davidiana prunusdavidiana(Carr.) dry mature seed of Franch..Gather after fruit maturation, removing sarcocarp and nucleocapsid, take out seed, dry.All parts of the country are generally cultivated.There is blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, effect of relieving cough and asthma.[effect and effect] can be used for blood circulation promoting and blood stasis dispelling, alleviates dyspepsia.For amenorrhea, injury from falling down, dysmenorrhea, dryness of the intestine constipation ， WEIJIA mass in the abdomen.Semen Persicae sugariness is bitter, enters lung, flat, liver, large intestine channel; There is blood stasis removing and clots absorbing, moisturize effect of laxation; Control amenorrhea, dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, traumatic injury, dryness of the intestine constipation.
Flos Carthami: this product is feverfew flos CarthamicarthamustinctoriusL. drying flower.Pluck when summer, flower was red by xanthochromia and get tubular flower, note the ovary of not hindering base portion, removing impurity, dry in the shade or low baking temperature oven dry, now matter is softer, the red the best of color depth.(gather flower time, should to carry out time softer by not dry, the sharp thorn of bract of dew in morning as early as possible, but also too early unsuitable.) [nature and flavor] pungent, temperature.[return through] GUIXIN, Liver Channel.[function cures mainly] promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.
Radix Angelicae Pubescentis: be samphire Angelica pubescens angelicapubescensMaxim.f.biserrataShanetYuandry root.Excavate when Seedling at the beginning of spring has just germinateed or autumn Mo, stem and leaf was withered, removing fibrous root and silt, be dried to half-dried, bank up 2-3 days, is dried to absolutely dry after feeling like jelly again.[meridian distribution of property and flavor] is pungent, bitter, tepor.Return liver, kidney, urinary bladder channel.[effect and effect] expelling wind and dampness; Dispersing cold for relieving pain.For anemofrigid-damp arthralgia; Lumbocrural pain; Few cloudy volt wind headache, headache toothache.
Herba portulacae: this product is portulacaceous plant herba PortulacaeportulacaoleraceaL., with herbbe used as medicine.Herba Portulacae is a kind of wild herbs that the edge of a field roadside is seen everywhere, and it is drought-enduring, and vitality is very strong, even if pull up solarization of a specified duration, and also can not be withered.Its stem is soft and be layered on the ground, and leaf is very little and become to grow symmetrically.Six July opened little Hua, tied little pointed fruit, had the Semen Portulacae that Semen Lepidii fills in fruit.[meridian distribution of property and flavor]: cold in nature, sweet in the mouth acid.Enter heart channel, Liver Channel, spleen channel, large intestine channel.[effect and effect]: heat-clearing and toxic substances removing, cooling blood for hemostasis.
Summary of the invention
The object of the invention is the deficiency overcoming background technology, pharmaceutical composition of a kind of effective treatment synovitis and preparation method thereof is provided.
The present invention adopts following technical scheme to realize:
Treat a pharmaceutical composition for synovitis, it is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Calyx seu fructus physalis 10-20g Cortex Acanthopancis 10-20g Rhizoma Atractylodis Macrocephalae 10-15g Rhizoma Atractylodis 10-15g Fructus Chaenomelis 10-15g Radix Angelicae Sinensis 8-12g Radix Glycyrrhizae 8-12g Caulis Spatholobi 10-20g Radix Clematidis 10-20g Semen Phaseoli 25-35g Radix Paeoniae Alba 10-20g Radix Achyranthis Bidentatae 10-20g Cortex Phellodendri 8-12g Semen Coicis 25-35g Semen Persicae 8-12g Flos Carthami 8-12g Radix Angelicae Pubescentis 10-20g Herba portulacae 25-35g.
Preferably treat a pharmaceutical composition for synovitis, it is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Calyx seu fructus physalis 20g Cortex Acanthopancis 12g Rhizoma Atractylodis Macrocephalae 12g Rhizoma Atractylodis 12g Fructus Chaenomelis 12g Radix Angelicae Sinensis 10g Radix Glycyrrhizae 10g Caulis Spatholobi 15g Radix Clematidis 15g Semen Phaseoli 30g Radix Paeoniae Alba 15g Radix Achyranthis Bidentatae 15g Cortex Phellodendri 10g Semen Coicis 25g Semen Persicae 10g Flos Carthami 10g Radix Angelicae Pubescentis 10g Herba portulacae 25g.
Treat a pharmaceutical composition for synovitis, it is characterized in that this pharmaceutical composition can adopt pharmaceutics conventional method to make drop pill.
Treat a pharmaceutical composition for synovitis, it is characterized in that the concrete Fingers wound synovitis of described synovitis, degenerated synovitis, rheumatic synovitis.
Medicine composite for curing traumatic synovitis of the present invention, degenerated synovitis, rheumatic synovitis is evident in efficacy.
embodiment and experimental example
Embodiment 1: a kind of pharmaceutical composition for the treatment of synovitis and preparation method thereof
The composition of crude drug and weight portion are: Calyx seu fructus physalis 20g Cortex Acanthopancis 12g Rhizoma Atractylodis Macrocephalae 12g Rhizoma Atractylodis 12g Fructus Chaenomelis 12g Radix Angelicae Sinensis 10g Radix Glycyrrhizae 10g Caulis Spatholobi 15g Radix Clematidis 15g Semen Phaseoli 30g Radix Paeoniae Alba 15g Radix Achyranthis Bidentatae 15g Cortex Phellodendri 10g Semen Coicis 25g Semen Persicae 10g Flos Carthami 10g Radix Angelicae Pubescentis 10g Herba portulacae 25g;
Preparation method: get Calyx seu fructus physalis 20g by crude drug proportioning, Cortex Acanthopancis 12g, Rhizoma Atractylodis Macrocephalae 12g, Rhizoma Atractylodis 12g, Fructus Chaenomelis 12g, Radix Angelicae Sinensis 10g, Radix Glycyrrhizae 10g, Caulis Spatholobi 15g, Radix Clematidis 15g, Semen Phaseoli 30g, Radix Paeoniae Alba 15g, Radix Achyranthis Bidentatae 15g, Cortex Phellodendri 10g, Semen Coicis 25g, Semen Persicae 10g, Flos Carthami 10g, Radix Angelicae Pubescentis 10g, Herba portulacae 25g, mixing, with weight percent concentration 35% ethanol as solvent, extract at 45 DEG C of warm macerating, extraction time is 4 times, each extraction time is 3 hours, each solvent load is 14 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.12, filter, medicinal liquid is by ADS-8 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting ADS-8 macroporous adsorptive resins of weight percent concentration 65% again, collect weight percent concentration 65% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition,
The preparation of medicament composition dropping pills: take polyethylene glycol 6000 180g water-bath (80 DEG C) heating and boil molten, add pharmaceutical composition 30g, stirring, is coolant with liquid paraffin, puts in glass tubing (4*80cm), chilling temperature is 8 DEG C, drip internal-and external diameter is 7.0/2.0 (mm/mm), and drip is 1.5cm apart from liquid level, drips speed with per minute 50 for optimum condition, blot the condensing agent on drop pill surface with cotton, obtain medicament composition dropping pills.
Embodiment 2: a kind of pharmaceutical composition for the treatment of synovitis and preparation method thereof
The composition of crude drug and weight portion are: Calyx seu fructus physalis 10g Cortex Acanthopancis 20g Rhizoma Atractylodis Macrocephalae 10g Rhizoma Atractylodis 15g Fructus Chaenomelis 10g Radix Angelicae Sinensis 12g Radix Glycyrrhizae 8g Caulis Spatholobi 20g Radix Clematidis 10g Semen Phaseoli 35g Radix Paeoniae Alba 10g Radix Achyranthis Bidentatae 20g Cortex Phellodendri 8g Semen Coicis 35g Semen Persicae 8g Flos Carthami 12g Radix Angelicae Pubescentis 10g Herba portulacae 35g;
Preparation method: get Calyx seu fructus physalis 10g by crude drug proportioning, Cortex Acanthopancis 20g, Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Atractylodis 15g, Fructus Chaenomelis 10g, Radix Angelicae Sinensis 12g, Radix Glycyrrhizae 8g, Caulis Spatholobi 20g, Radix Clematidis 10g, Semen Phaseoli 35g, Radix Paeoniae Alba 10g, Radix Achyranthis Bidentatae 20g, Cortex Phellodendri 8g, Semen Coicis 35g, Semen Persicae 8g, Flos Carthami 12g, Radix Angelicae Pubescentis 10g, Herba portulacae 35g, mixing, with weight percent concentration 35% ethanol as solvent, extract at 45 DEG C of warm macerating, extraction time is 4 times, each extraction time is 3 hours, each solvent load is 14 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.12, filter, medicinal liquid is by ADS-8 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting ADS-8 macroporous adsorptive resins of weight percent concentration 65% again, collect weight percent concentration 65% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition,
The preparation of medicament composition dropping pills: take polyethylene glycol 6000 180g water-bath (80 DEG C) heating and boil molten, add pharmaceutical composition 30g, stirring, is coolant with liquid paraffin, puts in glass tubing (4*80cm), chilling temperature is 8 DEG C, drip internal-and external diameter is 7.0/2.0 (mm/mm), and drip is 1.5cm apart from liquid level, drips speed with per minute 50 for optimum condition, blot the condensing agent on drop pill surface with cotton, obtain medicament composition dropping pills.
Embodiment 3: a kind of pharmaceutical composition for the treatment of synovitis and preparation method thereof
The composition of crude drug and weight portion are: Calyx seu fructus physalis 20g Cortex Acanthopancis 10g Rhizoma Atractylodis Macrocephalae 15g Rhizoma Atractylodis 10g Fructus Chaenomelis 15g Radix Angelicae Sinensis 8g Radix Glycyrrhizae 12g Caulis Spatholobi 10g Radix Clematidis 20g Semen Phaseoli 25g Radix Paeoniae Alba 20g Radix Achyranthis Bidentatae 10g Cortex Phellodendri 12g Semen Coicis 25g Semen Persicae 12g Flos Carthami 8g Radix Angelicae Pubescentis 20g Herba portulacae 25g;
Preparation method: get Calyx seu fructus physalis 20g by crude drug proportioning, Cortex Acanthopancis 10g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Atractylodis 10g, Fructus Chaenomelis 15g, Radix Angelicae Sinensis 8g, Radix Glycyrrhizae 12g, Caulis Spatholobi 10g, Radix Clematidis 20g, Semen Phaseoli 25g, Radix Paeoniae Alba 20g, Radix Achyranthis Bidentatae 10g, Cortex Phellodendri 12g, Semen Coicis 25g, Semen Persicae 12g, Flos Carthami 8g, Radix Angelicae Pubescentis 20g, Herba portulacae 25g, mixing, with weight percent concentration 35% ethanol as solvent, extract at 45 DEG C of warm macerating, extraction time is 4 times, each extraction time is 3 hours, each solvent load is 14 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.12, filter, medicinal liquid is by ADS-8 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting ADS-8 macroporous adsorptive resins of weight percent concentration 65% again, collect weight percent concentration 65% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition,
The preparation of medicament composition dropping pills: take polyethylene glycol 6000 180g water-bath (80 DEG C) heating and boil molten, add pharmaceutical composition 30g, stirring, is coolant with liquid paraffin, puts in glass tubing (4*80cm), chilling temperature is 8 DEG C, drip internal-and external diameter is 7.0/2.0 (mm/mm), and drip is 1.5cm apart from liquid level, drips speed with per minute 50 for optimum condition, blot the condensing agent on drop pill surface with cotton, obtain medicament composition dropping pills.
Experimental example 1: treatment traumatic synovitis experimental study
1 data and method
1.1 physical data
From traumatic synovitis patient 40 example that this city hospital outpatient data in April, 2012 in April, 2013 is perfect, all with reference to the synovitis diagnostic criteria in " the clinical disease for digest of Chinese and western medicine ".Make a definite diagnosis in conjunction with clinical manifestation and inspection.Man 25 example, female 15 example; Minimum 20 years old of age, maximum 74 years old; The course of disease is the shortest 7 days, the longest 15 years.There is clear and definite trauma history person 18 example, without clear and definite trauma history person 22 example, wherein take the photograph sheet through x-ray and confirm there is knee joint degenerative change person 24 example.
1.2 method
In conjunction with clinical symptoms and diagnostic result after patient admits, whole body assessment is done to patient, formulates the therapeutic scheme being applicable to patient.Adopt pharmaceutical composition (embodiment 1 pharmaceutical composition lot number 20120112), once take 2g, 3 times on the one.It within 2 weeks, is 1 course for the treatment of.
1.3 result
In 40 examples, cure 28 examples (pain and swelling disappears, and joint motion is normal, and floating patella test is negative, without recidivist); 12 examples that take a turn for the better (knee joint swells and ache and alleviates, and joint movement function improves); Total effective rate is 100%, and the course for the treatment of is the longest 12 weeks, the shortest 1 week.
Experimental example 2: treatment synovitis test
1, Cui XX, slight knee joint chronic trauma synovitis patient, in May, 2011 starts to take this medicine, once takes 2g, 3 times on the one.It within 2 weeks, is 1 course for the treatment of.Recovery from illness in 15 days, does not recur so far.
2, old XX, degenerated synovitis patient, in October, 2012 starts to take this medicine, once takes 2g, 3 times on the one, within 2 weeks, is 1 course for the treatment of.Recovery from illness in 42 days, does not recur so far.
3, king XX, rheumatic synovitis patient, in July, 2012 starts to take this medicine, once takes 2g, 3 times on the one.It within 2 weeks, is 1 course for the treatment of.Recovery from illness in 68 days, does not recur so far.

Claims (4)

1. treat a pharmaceutical composition for synovitis, it is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Calyx seu fructus physalis 10-20g Cortex Acanthopancis 10-20g Rhizoma Atractylodis Macrocephalae 10-15g Rhizoma Atractylodis 10-15g Fructus Chaenomelis 10-15g Radix Angelicae Sinensis 8-12g Radix Glycyrrhizae 8-12g Caulis Spatholobi 10-20g Radix Clematidis 10-20g Semen Phaseoli 25-35g Radix Paeoniae Alba 10-20g Radix Achyranthis Bidentatae 10-20g Cortex Phellodendri 8-12g Semen Coicis 25-35g Semen Persicae 8-12g Flos Carthami 8-12g Radix Angelicae Pubescentis 10-20g Herba portulacae 25-35g.
2. a kind of pharmaceutical composition for the treatment of synovitis according to claim 1, is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Calyx seu fructus physalis 20g Cortex Acanthopancis 12g Rhizoma Atractylodis Macrocephalae 12g Rhizoma Atractylodis 12g Fructus Chaenomelis 12g Radix Angelicae Sinensis 10g Radix Glycyrrhizae 10g Caulis Spatholobi 15g Radix Clematidis 15g Semen Phaseoli 30g Radix Paeoniae Alba 15g Radix Achyranthis Bidentatae 15g Cortex Phellodendri 10g Semen Coicis 25g Semen Persicae 10g Flos Carthami 10g Radix Angelicae Pubescentis 10g Herba portulacae 25g.
3. a kind of pharmaceutical composition for the treatment of synovitis according to claim 1, is characterized in that this pharmaceutical composition can adopt pharmaceutics conventional method to make drop pill.
4. a kind of pharmaceutical composition for the treatment of synovitis according to claim 1, is characterized in that the concrete Fingers wound synovitis of described synovitis, degenerated synovitis, rheumatic synovitis.
CN201510871949.3A 2015-12-03 2015-12-03 Drug combination for treating synovitis Withdrawn CN105362810A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106214878A (en) * 2016-08-31 2016-12-14 山东省文登整骨医院 A kind of Chinese medicine composition treating synovitis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106214878A (en) * 2016-08-31 2016-12-14 山东省文登整骨医院 A kind of Chinese medicine composition treating synovitis

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Application publication date: 20160302